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Aliases for PUS3 Gene

Aliases for PUS3 Gene

  • Pseudouridylate Synthase 3 2 3
  • TRNA Pseudouridylate Synthase 3 3 4
  • TRNA Pseudouridine Synthase 3 3 4
  • TRNA-Uridine Isomerase 3 3 4
  • 2610020J05Rik 3
  • EC 5.4.99.45 4
  • FKSG32 3

External Ids for PUS3 Gene

Previous GeneCards Identifiers for PUS3 Gene

  • GC11M125268
  • GC11M125763
  • GC11M121705

Summaries for PUS3 Gene

Entrez Gene Summary for PUS3 Gene

  • The protein encoded by this gene catalyzes the formation of tRNA pseudouridine from tRNA uridine at position 39 in the anticodon stem and loop of transfer RNAs. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for PUS3 Gene

PUS3 (Pseudouridylate Synthase 3) is a Protein Coding gene. GO annotations related to this gene include RNA binding and pseudouridine synthase activity.

UniProtKB/Swiss-Prot for PUS3 Gene

  • Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PUS3 Gene

Genomics for PUS3 Gene

Regulatory Elements for PUS3 Gene

Genomic Location for PUS3 Gene

Chromosome:
11
Start:
125,893,485 bp from pter
End:
125,903,369 bp from pter
Size:
9,885 bases
Orientation:
Minus strand

Genomic View for PUS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PUS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PUS3 Gene

Proteins for PUS3 Gene

  • Protein details for PUS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZE2-PUS3_HUMAN
    Recommended name:
    tRNA pseudouridine(38/39) synthase
    Protein Accession:
    Q9BZE2
    Secondary Accessions:
    • B2RAM0
    • Q96D17
    • Q96J23
    • Q96NB4

    Protein attributes for PUS3 Gene

    Size:
    481 amino acids
    Molecular mass:
    55647 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PUS3 Gene

Proteomics data for PUS3 Gene at MOPED

Post-translational modifications for PUS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PUS3 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PUS3

No data available for DME Specific Peptides for PUS3 Gene

Domains & Families for PUS3 Gene

Suggested Antigen Peptide Sequences for PUS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZE2

UniProtKB/Swiss-Prot:

PUS3_HUMAN :
  • Belongs to the tRNA pseudouridine synthase TruA family.
Family:
  • Belongs to the tRNA pseudouridine synthase TruA family.
genes like me logo Genes that share domains with PUS3: view

No data available for Gene Families for PUS3 Gene

Function for PUS3 Gene

Molecular function for PUS3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
tRNA uridine(38/39) = tRNA pseudouridine(38/39)
UniProtKB/Swiss-Prot Function:
Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs.

Enzyme Numbers (IUBMB) for PUS3 Gene

Gene Ontology (GO) - Molecular Function for PUS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0009982 pseudouridine synthase activity IEA --
genes like me logo Genes that share ontologies with PUS3: view

Phenotypes for PUS3 Gene

genes like me logo Genes that share phenotypes with PUS3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PUS3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PUS3 Gene

Localization for PUS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PUS3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PUS3 Gene COMPARTMENTS Subcellular localization image for PUS3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PUS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PUS3: view

Pathways & Interactions for PUS3 Gene

SuperPathways for PUS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PUS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis --
GO:0008033 tRNA processing --
GO:0009451 RNA modification --
GO:0031119 tRNA pseudouridine synthesis IEA --
genes like me logo Genes that share ontologies with PUS3: view

No data available for Pathways by source and SIGNOR curated interactions for PUS3 Gene

Drugs & Compounds for PUS3 Gene

(1) Drugs for PUS3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine Experimental Pharma 0

(1) Additional Compounds for PUS3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
  • 5-(b-delta-Ribofuranosyl)uracil
  • 5-b-D-Ribofuranosyl-Uracil
  • 5-beta-delta-Ribofuranosyl-Uracil
  • 5-Ribosyluracil
1445-07-4
genes like me logo Genes that share compounds with PUS3: view

Transcripts for PUS3 Gene

Unigene Clusters for PUS3 Gene

Pseudouridylate synthase 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PUS3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PUS3 Gene

No ASD Table

Relevant External Links for PUS3 Gene

GeneLoc Exon Structure for
PUS3
ECgene alternative splicing isoforms for
PUS3

Expression for PUS3 Gene

mRNA expression in normal human tissues for PUS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PUS3 Gene

This gene is overexpressed in Heart (51.8) and Adipocyte (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PUS3 Gene



SOURCE GeneReport for Unigene cluster for PUS3 Gene Hs.660922

genes like me logo Genes that share expression patterns with PUS3: view

Protein tissue co-expression partners for PUS3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PUS3 Gene

Orthologs for PUS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PUS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PUS3 35
  • 89.86 (n)
  • 88.96 (a)
PUS3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PUS3 35
  • 89.07 (n)
  • 88.73 (a)
PUS3 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pus3 35
  • 86.93 (n)
  • 86.16 (a)
Pus3 16
Pus3 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PUS3 35
  • 99.58 (n)
  • 99.38 (a)
PUS3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pus3 35
  • 85.51 (n)
  • 84.39 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PUS3 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PUS3 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves PUS3 35
  • 68.13 (n)
  • 71.36 (a)
PUS3 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PUS3 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pus3 35
  • 60.84 (n)
  • 59.71 (a)
zebrafish
(Danio rerio)
Actinopterygii pus3 35
  • 59.03 (n)
  • 58 (a)
pus3 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010807 35
  • 52.36 (n)
  • 49.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3045 35
  • 49.96 (n)
  • 45.43 (a)
CG3045 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-124 35
  • 50.4 (n)
  • 36.46 (a)
tag-124 36
  • 33 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL003W 35
  • 51.54 (n)
  • 48.36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14345g 35
  • 53.73 (n)
  • 45.82 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DEG1 35
  • 53.14 (n)
  • 47.85 (a)
DEG1 38
DEG1 36
  • 36 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC25B8.05 35
  • 52.33 (n)
  • 49.06 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for PUS3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PUS3 Gene

ENSEMBL:
Gene Tree for PUS3 (if available)
TreeFam:
Gene Tree for PUS3 (if available)

Paralogs for PUS3 Gene

No data available for Paralogs for PUS3 Gene

Variants for PUS3 Gene

Sequence variations from dbSNP and Humsavar for PUS3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs484049 -- 125,901,524(-) ACTGT(A/G)CTATC intron-variant
rs485785 -- 125,901,659(-) AATGC(C/G)TAACA intron-variant
rs513869 -- 125,902,081(-) GACTC(A/G)CTCCC intron-variant
rs4937067 -- 125,901,237(+) TGTTA(C/T)TTCTG intron-variant
rs4937068 -- 125,902,149(+) TTTCC(A/G)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PUS3 Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV Gain+Loss 17666407
nsv468888 CNV Loss 19166990
dgv248n67 CNV Gain 20364138

Variation tolerance for PUS3 Gene

Residual Variation Intolerance Score: 75.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.36; 85.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PUS3 Gene

HapMap Linkage Disequilibrium report
PUS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PUS3 Gene

Disorders for PUS3 Gene

Relevant External Links for PUS3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PUS3
genes like me logo Genes that share disorders with PUS3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PUS3 Gene

Publications for PUS3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA. (PMID: 11027153) Chen J. … Patton J.R. (Biochemistry 2000) 23 67
  3. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 67
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 67
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 67

Products for PUS3 Gene

Sources for PUS3 Gene

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