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Aliases for PUS3 Gene

Aliases for PUS3 Gene

  • Pseudouridylate Synthase 3 2 3
  • TRNA Pseudouridylate Synthase 3 3 4
  • TRNA Pseudouridine Synthase 3 3 4
  • TRNA-Uridine Isomerase 3 3 4
  • TRNA Pseudouridine(38/39) Synthase 3
  • 2610020J05Rik 3
  • EC 4
  • FKSG32 3

External Ids for PUS3 Gene

Previous GeneCards Identifiers for PUS3 Gene

  • GC11M125268
  • GC11M125763
  • GC11M121705

Summaries for PUS3 Gene

Entrez Gene Summary for PUS3 Gene

  • The protein encoded by this gene catalyzes the formation of tRNA pseudouridine from tRNA uridine at position 39 in the anticodon stem and loop of transfer RNAs. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for PUS3 Gene

PUS3 (Pseudouridylate Synthase 3) is a Protein Coding gene. GO annotations related to this gene include RNA binding and pseudouridine synthase activity.

UniProtKB/Swiss-Prot for PUS3 Gene

  • Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PUS3 Gene

Genomics for PUS3 Gene

Regulatory Elements for PUS3 Gene

Genomic Location for PUS3 Gene

125,893,485 bp from pter
125,903,250 bp from pter
9,766 bases
Minus strand

Genomic View for PUS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PUS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PUS3 Gene

Proteins for PUS3 Gene

  • Protein details for PUS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA pseudouridine(38/39) synthase
    Protein Accession:
    Secondary Accessions:
    • B2RAM0
    • Q96D17
    • Q96J23
    • Q96NB4

    Protein attributes for PUS3 Gene

    481 amino acids
    Molecular mass:
    55647 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PUS3 Gene

Proteomics data for PUS3 Gene at MOPED

Post-translational modifications for PUS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PUS3 Gene

No data available for DME Specific Peptides for PUS3 Gene

Domains for PUS3 Gene

Suggested Antigen Peptide Sequences for PUS3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BZE2
  • Belongs to the tRNA pseudouridine synthase TruA family.
genes like me logo Genes that share domains with PUS3: view

No data available for Gene Families for PUS3 Gene

Function for PUS3 Gene

Molecular function for PUS3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: tRNA uridine(38/39) = tRNA pseudouridine(38/39)
UniProtKB/Swiss-Prot Function: Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs.

Enzyme Numbers (IUBMB) for PUS3 Gene

Gene Ontology (GO) - Molecular Function for PUS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0009982 pseudouridine synthase activity IEA --
genes like me logo Genes that share ontologies with PUS3: view

Phenotypes for PUS3 Gene

genes like me logo Genes that share phenotypes with PUS3: view

Animal Model Products

CRISPR Products

miRNA for PUS3 Gene

miRTarBase miRNAs that target PUS3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PUS3 Gene

Localization for PUS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PUS3 Gene

Subcellular locations from

Jensen Localization Image for PUS3 Gene COMPARTMENTS Subcellular localization image for PUS3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PUS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PUS3: view

Pathways for PUS3 Gene

SuperPathways for PUS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PUS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis --
GO:0009451 RNA modification --
GO:0031119 tRNA pseudouridine synthesis IEA --
genes like me logo Genes that share ontologies with PUS3: view

No data available for Pathways by source for PUS3 Gene

Compounds for PUS3 Gene

(2) HMDB Compounds for PUS3 Gene

Compound Synonyms Cas Number PubMed IDs
  • 5-(b-D-Ribofuranosyl)uracil
  • 1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
genes like me logo Genes that share compounds with PUS3: view

Transcripts for PUS3 Gene

Unigene Clusters for PUS3 Gene

Pseudouridylate synthase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PUS3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PUS3 Gene

No ASD Table

Relevant External Links for PUS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PUS3 Gene

mRNA expression in normal human tissues for PUS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PUS3 Gene

SOURCE GeneReport for Unigene cluster for PUS3 Gene Hs.660922

genes like me logo Genes that share expressions with PUS3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PUS3 Gene

Orthologs for PUS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PUS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PUS3 35
  • 99.58 (n)
  • 99.38 (a)
PUS3 36
  • 99 (a)
(Bos Taurus)
Mammalia PUS3 35
  • 89.86 (n)
  • 88.96 (a)
PUS3 36
  • 89 (a)
(Canis familiaris)
Mammalia PUS3 35
  • 89.07 (n)
  • 88.73 (a)
PUS3 36
  • 89 (a)
(Mus musculus)
Mammalia Pus3 35
  • 86.93 (n)
  • 86.16 (a)
Pus3 16
Pus3 36
  • 85 (a)
(Monodelphis domestica)
Mammalia PUS3 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia PUS3 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Pus3 35
  • 85.51 (n)
  • 84.39 (a)
(Gallus gallus)
Aves PUS3 35
  • 68.13 (n)
  • 71.36 (a)
PUS3 36
  • 66 (a)
(Anolis carolinensis)
Reptilia PUS3 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pus3 35
  • 60.84 (n)
  • 59.71 (a)
(Danio rerio)
Actinopterygii pus3 35
  • 59.03 (n)
  • 58 (a)
pus3 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010807 35
  • 52.36 (n)
  • 49.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3045 35
  • 49.96 (n)
  • 45.43 (a)
CG3045 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea tag-124 35
  • 50.4 (n)
  • 36.46 (a)
tag-124 36
  • 33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL003W 35
  • 51.54 (n)
  • 48.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DEG1 35
  • 53.14 (n)
  • 47.85 (a)
DEG1 36
  • 36 (a)
DEG1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14345g 35
  • 53.73 (n)
  • 45.82 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC25B8.05 35
  • 52.33 (n)
  • 49.06 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for PUS3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PUS3 Gene

Gene Tree for PUS3 (if available)
Gene Tree for PUS3 (if available)

Paralogs for PUS3 Gene

No data available for Paralogs for PUS3 Gene

Variants for PUS3 Gene

Sequence variations from dbSNP and Humsavar for PUS3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs484049 -- 125,901,524(-) ACTGT(A/G)CTATC intron-variant
rs485785 -- 125,901,659(-) AATGC(C/G)TAACA intron-variant
rs513869 -- 125,902,081(-) GACTC(A/G)CTCCC intron-variant
rs4937067 -- 125,901,237(+) TGTTA(C/T)TTCTG intron-variant
rs4937068 -- 125,902,149(+) TTTCC(A/G)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PUS3 Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV Gain+Loss 17666407
nsv468888 CNV Loss 19166990
dgv248n67 CNV Gain 20364138

Relevant External Links for PUS3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PUS3 Gene

Disorders for PUS3 Gene

(1) University of Copenhagen DISEASES for PUS3 Gene

genes like me logo Genes that share disorders with PUS3: view

No data available for UniProtKB/Swiss-Prot for PUS3 Gene

Publications for PUS3 Gene

  1. Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA. (PMID: 11027153) Chen J. … Patton J.R. (Biochemistry 2000) 3 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for PUS3 Gene

Sources for PUS3 Gene

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