Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PUS10 Gene

protein-coding   GIFtS: 49
GCID: GC02M061167

Pseudouridylate Synthase 10

(Previous name: coiled-coil domain containing 139)
(Previous symbol: CCDC139)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pseudouridylate Synthase 101 2     TRNA Pseudouridylate Synthase2 3
CCDC1391 2 3     TRNA-Uridine Isomerase2 3
DOBI2 3 5     Pseudouridine Synthase 102
Coiled-Coil Domain Containing 1391 2     Putative TRNA Pseudouridine Synthase Pus102
Coiled-Coil Domain-Containing Protein 1392 3     EC 5.4.99.-3
Psi55 Synthase2 3     PUS15
TRNA Pseudouridine 55 Synthase2 3     EC 5.4.998

External Ids:    HGNC: 265051   Entrez Gene: 1509622   Ensembl: ENSG000001629277   OMIM: 6127875   UniProtKB: Q3MIT23   

Export aliases for PUS10 gene to outside databases

Previous GC identifers: GC02M061023 GC02M060909


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PUS10 Gene:
Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional
nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis.
Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer,
ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and
assembly of tRNAs (McCleverty et al., 2007 (PubMed 17900615)).(supplied by OMIM, May 2009)

GeneCards Summary for PUS10 Gene: 
PUS10 (pseudouridylate synthase 10) is a protein-coding gene. Diseases associated with PUS10 include conduct disorder, and ankylosing spondylitis. GO annotations related to this gene include pseudouridine synthase activity and RNA binding.

UniProtKB/Swiss-Prot: PUS10_HUMAN, Q3MIT2
Function: Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal,
and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs
(Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for
the progression of the apoptotic signal through intrinsic mitochondrial cell death




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PUS10 gene promoter:
         p53   CUTL1   Tal-1beta   E47   YY1   POU2F1   POU2F1b   POU2F1a   POU2F1c   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPUS10 promoter sequence
   Search SABiosciences Chromatin IP Primers for PUS10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PUS10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.1   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p16.1

PUS10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PUS10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M061167:  view genomic region     (about GC identifiers)

Start:
61,167,357 bp from pter      End:
61,245,394 bp from pter
Size:
78,038 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PUS10_HUMAN, Q3MIT2 (See protein sequence)
Recommended Name: Putative tRNA pseudouridine synthase Pus10  
Size: 529 amino acids; 60244 Da
Sequence caution: Sequence=CAI46123.1; Type=Miscellaneous discrepancy; Note=Partially unspliced pre-RNA;
1 PDB 3D structure from and Proteopedia for PUS10:
2V9K (3D)    
Secondary accessions: Q5JPJ5 Q96MI8

Explore the universe of human proteins at neXtProt for PUS10: NX_Q3MIT2

Explore proteomics data for PUS10 at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically cleaved during TRAIL-induced cell death. Cleaved, in vitro, either by caspase-3 or caspase-8
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q3MIT2

  • 2 DME Specific Peptides for PUS10 (Q3MIT2)
     TQAGTYIKE  SSGREDVDVR 

    PUS10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PUS10 Protein Expression
    REFSEQ proteins: NP_653310.2  
    ENSEMBL proteins: 
     ENSP00000326003   ENSP00000386074   ENSP00000403880   ENSP00000402185   ENSP00000381651  

    Human Recombinant Protein Products for PUS10: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PUS10
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PUS10
    GenScript Custom Purified and Recombinant Proteins Services for PUS10
    Novus Biologicals PUS10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PUS10 


    PUS10 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PUS10
    GenScript Custom Superior Antibodies Services for PUS10
    Novus Biologicals PUS10 Antibody
    Abcam antibodies for PUS10
    Cloud-Clone Corp. Antibodies for PUS10 
    Search ThermoFisher Antibodies for PUS10
    LSBio Antibodies in human, mouse, rat for PUS10 

    Assay Products for PUS10: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PUS10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PUS10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PUS10 
    Cloud-Clone Corp. CLIAs for PUS10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR020103 PsdUridine_synth_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q3MIT2

    ProtoNet protein and cluster: Q3MIT2

    UniProtKB/Swiss-Prot: PUS10_HUMAN, Q3MIT2
    Similarity: Belongs to the pseudouridine synthase Pus10 family


    PUS10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PUS10_HUMAN, Q3MIT2
    Function: Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal,
    and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs
    (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for
    the progression of the apoptotic signal through intrinsic mitochondrial cell death
    Catalytic activity: tRNA uridine = tRNA pseudouridine

         Enzyme Numbers (IUBMB): EC 5.4.992 EC 5.4.99.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0009982pseudouridine synthase activity IEA--
         
    PUS10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PUS10:
     Increased viability with TRAIL 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PUS10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PUS10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PUS10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PUS10 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PUS10
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate PUS10 (see all 25):
    hsa-miR-30c hsa-miR-640 hsa-miR-219-5p hsa-miR-30d hsa-miR-877* hsa-miR-10b* hsa-miR-9 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidPUS10 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PUS10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PUS10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PUS10
    Sirion Biotech Customized adenovirus for overexpression of PUS10

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PUS10 (see all 7)
    OriGene ORF clones in mouse, rat for PUS10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PUS10 (NM_144709)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PUS10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUS10
    Sirion Biotech Customized lentivirus for stable overexpression of PUS10 
                         Customized lentivirus expression plasmids for stable overexpression of PUS10 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PUS10
    Search LifeMap BioReagents cell lines for PUS10
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PUS10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PUS10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PUS10 (ENSP000003260034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM206AENSP000003637534STRING: ENSP00000363753
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001522pseudouridine synthesis IEA--
    GO:0008033tRNA processing IEA--
    GO:0009451RNA modification ----

    PUS10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PUS10

    2 HMDB Compounds for PUS10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pseudouridine5-(b-D-Ribofuranosyl)uracil (see all 12)1445-07-4--
    Uridine1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione (see all 9)58-96-8--

    Search CenterWatch for drugs/clinical trials and news about PUS10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PUS10 gene: 
    NM_144709.2  

    Unigene Cluster for PUS10:

    Pseudouridylate synthase 10
    Hs.368348  [show with all ESTs]
    Unigene Representative Sequence: AL832208
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602599 ENST00000316752(uc010fci.3 uc002sao.3 uc010ypk.2)
    ENST00000407787 ENST00000430495 ENST00000421319 ENST00000398658(uc002sap.1 uc002saq.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PUS10
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate PUS10 (see all 25):
    hsa-miR-30c hsa-miR-640 hsa-miR-219-5p hsa-miR-30d hsa-miR-877* hsa-miR-10b* hsa-miR-9 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidPUS10 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PUS10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PUS10
    Clone
    Products:
         
    OriGene clones in human, mouse for PUS10 (see all 7)
    OriGene ORF clones in mouse, rat for PUS10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PUS10 (NM_144709)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PUS10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUS10
    Sirion Biotech Customized lentivirus for stable overexpression of PUS10 
                         Customized lentivirus expression plasmids for stable overexpression of PUS10 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PUS10
    OriGene qSTAR qPCR primer pairs in human, mouse for PUS10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PUS10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PUS10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PUS10

    Additional mRNA sequence: 

    AK021502.1 AK056874.1 AK291729.1 AL832208.1 BC060323.1 BC065197.1 BC101680.1 BC101706.1 
    BC143480.1 

    9 DOTS entries:

    DT.410843  DT.100744161  DT.97795960  DT.100806543  DT.102831152  DT.86852422  DT.95363132  DT.100745630 
    DT.95201729 

    24/59 AceView cDNA sequences (see all 59):

    AK056874 AA213623 Z44756 AA813267 AW295480 BC065197 BM742823 NM_144709 
    AA992539 AA748843 AI935832 AK130934 AA766745 BU624272 AW341552 AA714637 
    BX496421 AA125988 AW503429 BG546841 AV700540 AA878516 BF514791 AA731778 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PUS10 expression in normal human tissues (normalized intensities)      PUS10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTAATTTT
    PUS10 Expression
    About this image


    PUS10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Lymph (Hematopoietic System)
             lymph node   

    See PUS10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PUS10

    SOURCE GeneReport for Unigene cluster: Hs.368348
        SABiosciences Custom PCR Arrays for PUS10
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PUS10
    OriGene qSTAR qPCR primer pairs in human, mouse for PUS10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PUS10
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PUS10
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PUS10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PUS10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PUS10 gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pus101 , 5 pseudouridylate synthase 101, 5 86.21(n)1
    86.91(a)1
      11 (14.34 cM)5
    744671  NM_001033654.21  NP_001028826.11 
     236656745 
    chicken
    (Gallus gallus)
    Aves PUS101 pseudouridylate synthase 10 76.81(n)
    75.61(a)
      421198  NM_001199449.1  NP_001186378.1 
    lizard
    (Anolis carolinensis)
    Reptilia PUS106
    Uncharacterized protein
    69(a)
    1 ↔ 1
    GL343523.1(410868-428429)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU900034.12   -- 74.24(n)    BU900034.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ605475.12   -- 78.47(n)    BQ605475.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37091 CG3709 46.06(n)
    37.05(a)
      33178  NM_134656.3  NP_608500.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48C3A.201 Protein Y48C3A.20 47.14(n)
    37.14(a)
      174977  NM_064418.1  NP_496819.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G204101 Pseudouridine synthase family protein 50.04(n)
    39.4(a)
      838630  NM_101892.3  NP_173466.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g05617001 hypothetical protein 47.91(n)
    37.85(a)
      4336659  NM_001060089.2  NP_001053554.2 


    ENSEMBL Gene Tree for PUS10 (if available)
    TreeFam Gene Tree for PUS10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1326 SNPs in PUS10 are shown (see all 1326)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356174
    A colorectal cancer sample4--see VAR_0356172 T I mis40--------
    rs748029081,2
    --61167051(+) CCATGA/GTTCAG 1 -- int10--------
    rs1456637411,2
    --61167130(+) AATAGA/CATCAT 1 -- int10--------
    rs1839502021,2
    --61167153(+) TTTCAC/TAATAA 1 -- int10--------
    rs728890201,2
    C--61167167(+) AGGGTA/CGCCTT 1 -- int15Minor allele frequency- C:0.14WA CSA NA EA 362
    rs130148031,2
    C,F,H--61167216(+) TCTTAT/CGTGGA 1 -- int114Minor allele frequency- C:0.07NS EA NA 1772
    rs1887269041,2
    --61167258(+) GAAAAG/TATTTG 1 -- int10--------
    rs1381163141,2
    --61167385(+) TTTCTC/TTTGAC 1 -- int10--------
    rs10538621,2
    C,F,O,A,H--61167761(-) GAAGAT/CTTCTA 1 -- ut3122Minor allele frequency- C:0.33MN NS EA NA WA 2532
    rs1807623501,2
    --61167865(+) TCCTAA/TATTAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PUS10 (61167357 - 61245394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PUS10:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834215CNV Loss17160897
    nsv874210CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PUS10
    DNA2.0 Custom Variant and Variant Library Synthesis for PUS10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612787    OMIM disorders: --

    6 diseases for PUS10:    About MalaCards
    conduct disorder    ankylosing spondylitis    celiac disease    crohn's disease
    spondylitis    ulcerative colitis


    PUS10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PUS10
    Human Genome Epidemiology (HuGE) Navigator: PUS10 (7 documents)

    Export disorders for PUS10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PUS10 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with PUS10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human Pus10, a novel pseudouridine synthase. (PubMed id 17900615)1, 2, 3 McCleverty C.J.... Kreusch A. (2007)
    2. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1, 4 Kenny E.E....Peter I. (2012)
    3. A meta-analysis of genome-wide association scans iden tifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease. (PubMed id 21298027)1, 4 Festen E.A....Rioux J.D. (2011)
    4. Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (2011)
    5. Genome-wide association identifies multiple ulcerativ e colitis susceptibility loci. (PubMed id 20228799)1, 4 McGovern D.P....Weersma R.K. (2010)
    6. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1, 4 Franke A....Parkes M. (2010)
    7. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    8. Evidence for genes on chromosome 2 contributing to al cohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1, 4 Dick D.M....Bierut L. (2010)
    9. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. (PubMed id 19068216)1, 4 Anderson C.A....Parkes M. (2009)
    10. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 150962 HGNC: 26505 AceView: FLJ32312 Ensembl:ENSG00000162927 euGenes: HUgn150962
    ECgene: PUS10 H-InvDB: PUS10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PUS10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PUS10 gene:
    Search GeneIP for patents involving PUS10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PUS10  
     OriGene qPCR primer pairs and template standards for PUS10   OriGene Protein Over-expression Lysate for PUS10  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PUS10  
     OriGene qSTAR qPCR primer pairs in human, mouse for PUS10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PUS10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PUS10   OriGene Custom Protein Services for PUS10  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PUS10
     QIAGEN SeqTarget long-range PCR primers for resequencing PUS10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PUS10
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PUS10
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PUS10
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PUS10
     GenScript Custom Purified and Recombinant Proteins Services for PUS10 GenScript cDNA clones with any tag delivered in your preferred vector for PUS10
     GenScript Custom Assay Services for PUS10 GenScript Custom Superior Antibodies Services for PUS10
     GenScript Custom overexpressing Cell Line Services for PUS10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PUS10 promoter
     Search Chromatin IP Primers for PUS10
     RT2 qPCR Primer Assay in human, mouse, rat PUS10
     Search GNC Networks for PUS10
     SABiosciences Custom PCR Arrays for PUS10
     Search Tocris compounds for PUS10
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PUS10 antibodies
     PUS10 lysates
     Antibodies for PUS10
     See all of Abcam's Antibodies, Kits and Proteins for PUS10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PUS10
     Antibodies for PUS10
     ELISAs for PUS10
     CLIAs for PUS10
     Search LifeMap BioReagents cell lines for PUS10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PUS10
     SwitchGear 3'UTR luciferase reporter plasmids for PUS10
     SwitchGear Promoter luciferase reporter plasmids for PUS10
     Search ThermoFisher Antibodies for PUS10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUS10
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PUS10
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PUS10
    Customized:
     lentivirus for stable overexpression of PUS10
     lentivirus expression plasmids for stable overexpression of PUS10
     adenovirus for overexpression of PUS10
     LSBio Antibodies in human, mouse, rat for PUS10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PUS10 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4