Aliases for PUS10 Gene
External Ids for PUS10 Gene
Previous HGNC Symbols for PUS10 Gene
Previous GeneCards Identifiers for PUS10 Gene
Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by OMIM, May 2009]
GeneCards Summary for PUS10 Gene
PUS10 (Pseudouridylate Synthase 10) is a Protein Coding gene. GO annotations related to this gene include RNA binding and pseudouridine synthase activity.
UniProtKB/Swiss-Prot for PUS10 Gene
Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.