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PUS10 Gene

protein-coding   GIFtS: 50
GCID: GC02M061167

Pseudouridylate Synthase 10

(Previous name: coiled-coil domain containing 139)
(Previous symbol: CCDC139)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pseudouridylate Synthase 101 2     TRNA Pseudouridylate Synthase2 3
CCDC1391 2 3     TRNA-Uridine Isomerase2 3
DOBI2 3 5     Pseudouridine Synthase 102
Coiled-Coil Domain Containing 1391 2     Putative TRNA Pseudouridine Synthase Pus102
Coiled-Coil Domain-Containing Protein 1392 3     EC 5.4.99.-3
Psi55 Synthase2 3     PUS15
TRNA Pseudouridine 55 Synthase2 3     EC 5.4.998

External Ids:    HGNC: 265051   Entrez Gene: 1509622   Ensembl: ENSG000001629277   OMIM: 6127875   UniProtKB: Q3MIT23   

Export aliases for PUS10 gene to outside databases

Previous GC identifers: GC02M061023 GC02M060909


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PUS10 Gene:
Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional
nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis.
Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer,
ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and
assembly of tRNAs (McCleverty et al., 2007 (PubMed 17900615)).(supplied by OMIM, May 2009)

GeneCards Summary for PUS10 Gene:
PUS10 (pseudouridylate synthase 10) is a protein-coding gene. Diseases associated with PUS10 include conduct disorder, and crohn's disease. GO annotations related to this gene include pseudouridine synthase activity and RNA binding.

UniProtKB/Swiss-Prot: PUS10_HUMAN, Q3MIT2
Function: Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal,
and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs
(Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for
the progression of the apoptotic signal through intrinsic mitochondrial cell death




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PUS10 gene promoter:
         p53   CUTL1   Tal-1beta   E47   YY1   POU2F1   POU2F1b   POU2F1a   POU2F1c   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPUS10 promoter sequence
   Search Chromatin IP Primers for PUS10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PUS10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.1   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p16.1

PUS10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PUS10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M061167:  view genomic region     (about GC identifiers)

Start:
61,167,357 bp from pter      End:
61,245,394 bp from pter
Size:
78,038 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PUS10_HUMAN, Q3MIT2 (See protein sequence)
Recommended Name: Putative tRNA pseudouridine synthase Pus10  
Size: 529 amino acids; 60244 Da
Sequence caution: Sequence=CAI46123.1; Type=Miscellaneous discrepancy; Note=Partially unspliced pre-RNA;
1 PDB 3D structure from and Proteopedia for PUS10:
2V9K (3D)    
Secondary accessions: Q5JPJ5 Q96MI8

Explore the universe of human proteins at neXtProt for PUS10: NX_Q3MIT2

Explore proteomics data for PUS10 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved during TRAIL-induced cell death. Cleaved, in vitro, either by caspase-3 or caspase-81
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for PUS10 (Q3MIT2)
     TQAGTYIKE  SSGREDVDVR 


    See PUS10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_653310.2  
    ENSEMBL proteins: 
     ENSP00000326003   ENSP00000386074   ENSP00000403880   ENSP00000402185   ENSP00000381651  

    PUS10 Human Recombinant Protein Products:

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    Novus Biologicals PUS10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PUS10

    PUS10 Antibody Products:

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    Abcam antibodies for PUS10
    Cloud-Clone Corp. Antibodies for PUS10
    Search ThermoFisher Antibodies for PUS10
    LSBio Antibodies in human, mouse, rat for PUS10

    PUS10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PUS10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PUS10
    Cloud-Clone Corp. CLIAs for PUS10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR020103 PsdUridine_synth_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q3MIT2

    ProtoNet protein and cluster: Q3MIT2

    UniProtKB/Swiss-Prot: PUS10_HUMAN, Q3MIT2
    Similarity: Belongs to the pseudouridine synthase Pus10 family


    PUS10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PUS10_HUMAN, Q3MIT2
    Function: Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal,
    and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs
    (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for
    the progression of the apoptotic signal through intrinsic mitochondrial cell death
    Catalytic activity: tRNA uridine = tRNA pseudouridine

         Enzyme Numbers (IUBMB): EC 5.4.992 EC 5.4.99.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0009982pseudouridine synthase activity IEA--
         
    PUS10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PUS10:
     Increased viability with TRAIL 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PUS10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PUS10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PUS10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PUS10

    miRNA
    Products:
        
    miRTarBase miRNAs that target PUS10:
    hsa-mir-335-5p (MIRT018305)

    Block miRNA regulation of human, mouse, rat PUS10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PUS10 (see all 25):
    hsa-miR-30c hsa-miR-640 hsa-miR-219-5p hsa-miR-30d hsa-miR-877* hsa-miR-10b* hsa-miR-9 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidPUS10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PUS10
    Predesigned siRNA for gene silencing in human, mouse, rat PUS10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PUS10

    Clone
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    OriGene clones in human, mouse for PUS10 (see all 6)
    OriGene ORF clones in mouse, rat for PUS10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PUS10 (NM_144709)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PUS10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUS10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PUS10
    Browse ESI BIO Cell Lines and PureStem Progenitors for PUS10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PUS10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PUS10
    Interactions:

        Search GeneGlobe Interaction Network for PUS10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for PUS10 (ENSP000003260034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM206AENSP000003637534STRING: ENSP00000363753
    LRRC63ENSP000004088284STRING: ENSP00000408828
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001522pseudouridine synthesis IEA--
    GO:0008033tRNA processing IEA--
    GO:0009451RNA modification ----

    PUS10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PUS10

    2 HMDB Compounds for PUS10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pseudouridine5-(b-D-Ribofuranosyl)uracil (see all 12)1445-07-4--
    Uridine1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione (see all 9)58-96-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PUS10 gene: 
    NM_144709.2  

    Unigene Cluster for PUS10:

    Pseudouridylate synthase 10
    Hs.368348  [show with all ESTs]
    Unigene Representative Sequence: AL832208
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602599 ENST00000316752(uc010fci.3 uc002sao.3 uc010ypk.2)
    ENST00000407787 ENST00000430495 ENST00000421319 ENST00000398658(uc002sap.1 uc002saq.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PUS10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PUS10 (see all 25):
    hsa-miR-30c hsa-miR-640 hsa-miR-219-5p hsa-miR-30d hsa-miR-877* hsa-miR-10b* hsa-miR-9 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidPUS10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PUS10
    Predesigned siRNA for gene silencing in human, mouse, rat PUS10
    Clone
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    OriGene clones in human, mouse for PUS10 (see all 6)
    OriGene ORF clones in mouse, rat for PUS10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PUS10 (NM_144709)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PUS10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUS10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PUS10
    OriGene qSTAR qPCR primer pairs in human, mouse for PUS10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PUS10
      QuantiTect SYBR Green Assays in human, mouse, rat PUS10
      QuantiFast Probe-based Assays in human, mouse, rat PUS10

    Additional mRNA sequence: 

    AK021502.1 AK056874.1 AK291729.1 AL832208.1 BC060323.1 BC065197.1 BC101680.1 BC101706.1 
    BC143480.1 

    9 DOTS entries:

    DT.410843  DT.100744161  DT.97795960  DT.100806543  DT.102831152  DT.86852422  DT.95363132  DT.100745630 
    DT.95201729 

    Selected AceView cDNA sequences (see all 59):

    AA992539 AW295480 Z44756 AA813267 NM_144709 BC065197 BM742823 AK056874 
    AA213623 BI255568 AI935832 BU624272 BG546841 AW500734 BF908565 AA766745 
    AK021502 AW576368 AA213749 AK130934 R37793 AA878516 BF514791 AL832208 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PUS10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTAATTTT
    PUS10 Expression
    About this image


    PUS10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PUS10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PUS10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368348
        Custom PCR Arrays for PUS10
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PUS10
    OriGene qSTAR qPCR primer pairs in human, mouse for PUS10
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    QuantiFast Probe-based Assays in human, mouse, rat PUS10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PUS10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PUS10 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pus101 , 5 pseudouridylate synthase 101, 5 86.21(n)1
    86.91(a)1
      11 (14.34 cM)5
    744671  NM_001033654.21  NP_001028826.11 
     236656745 
    chicken
    (Gallus gallus)
    Aves PUS101 pseudouridylate synthase 10 76.87(n)
    75.61(a)
      421198  NM_001199449.1  NP_001186378.1 
    lizard
    (Anolis carolinensis)
    Reptilia PUS106
    pseudouridylate synthase 10
    70(a)
    1 ↔ 1
    GL343523.1(410868-428429)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU900034.12   -- 74.24(n)    BU900034.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ605475.12   -- 78.47(n)    BQ605475.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37091 CG3709 46.22(n)
    37.53(a)
      33178  NM_134656.4  NP_608500.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48C3A.201 Y48C3A.20 47.54(n)
    37.14(a)
      174977  NM_064418.1  NP_496819.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G204101 AT1G20410 49.51(n)
    39.05(a)
      838630  NM_101892.3  NP_173466.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g05617001 Os04g0561700 47.91(n)
    37.85(a)
      4336659  NM_001060089.2  NP_001053554.2 


    ENSEMBL Gene Tree for PUS10 (if available)
    TreeFam Gene Tree for PUS10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PUS10 (see all 1326)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356174
    A colorectal cancer sample4--see VAR_0356172 T I mis40--------
    rs748029081,2
    --61167051(+) CCATGA/GTTCAG 1 -- int10--------
    rs1456637411,2
    --61167130(+) AATAGA/CATCAT 1 -- int10--------
    rs1839502021,2
    --61167153(+) TTTCAC/TAATAA 1 -- int10--------
    rs728890201,2
    C--61167167(+) AGGGTA/CGCCTT 1 -- int15Minor allele frequency- C:0.14WA CSA NA EA 362
    rs130148031,2
    C,F,H--61167216(+) TCTTAT/CGTGGA 1 -- int114Minor allele frequency- C:0.07NS EA NA 1772
    rs1887269041,2
    --61167258(+) GAAAAG/TATTTG 1 -- int10--------
    rs1381163141,2
    --61167385(+) TTTCTC/TTTGAC 1 -- int10--------
    rs10538621,2
    C,F,O,A,H--61167761(-) GAAGAT/CTTCTA 1 -- ut3122Minor allele frequency- C:0.33MN NS EA NA WA 2532
    rs1807623501,2
    --61167865(+) TCCTAA/TATTAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PUS10 (61167357 - 61245394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PUS10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834215CNV Loss17160897
    nsv874210CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PUS10
    DNA2.0 Custom Variant and Variant Library Synthesis for PUS10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612787    OMIM disorders: --

    12 diseases for PUS10:    
    About MalaCards
    conduct disorder    crohn's disease    ulcerative colitis    celiac disease
    ankylosing spondylitis    spondylitis    alcohol dependence    breast and colorectal cancer
    inflammatory bowel disease    colorectal cancer    malaria    cerebritis


    PUS10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PUS10
    Human Genome Epidemiology (HuGE) Navigator: PUS10 (7 documents)

    Export disorders for PUS10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PUS10 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with PUS10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human Pus10, a novel pseudouridine synthase. (PubMed id 17900615)1, 2, 3 McCleverty C.J.... Kreusch A. (J. Mol. Biol. 2007)
    2. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1, 4 Kenny E.E....Peter I. (PLoS Genet. 2012)
    3. A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease. (PubMed id 21298027)1, 4 Festen E.A....Rioux J.D. (PLoS Genet. 2011)
    4. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    5. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PubMed id 20228799)1, 4 McGovern D.P....Seielstad M. (Nat. Genet. 2010)
    6. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1, 4 Franke A....Parkes M. (Nat. Genet. 2010)
    7. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    8. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1, 4 Dick D.M....Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. (PubMed id 19068216)1, 4 Anderson C.A....Parkes M. (Gastroenterology 2009)
    10. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 150962 HGNC: 26505 AceView: FLJ32312 Ensembl:ENSG00000162927 euGenes: HUgn150962
    ECgene: PUS10 H-InvDB: PUS10

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PUS10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PUS10 gene:
    Search GeneIP for patents involving PUS10

    GeneCards and IP:
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