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Aliases for PURG Gene

Aliases for PURG Gene

  • Purine Rich Element Binding Protein G 2 3 5
  • Purine-Rich Element-Binding Protein Gamma 3
  • Pur-Gamma 3
  • PURG-A 3
  • PURG-B 3

External Ids for PURG Gene

Previous GeneCards Identifiers for PURG Gene

  • GC08M030758
  • GC08M031340
  • GC08M030946
  • GC08M030911
  • GC08M030972
  • GC08M029398
  • GC08M030853

Summaries for PURG Gene

Entrez Gene Summary for PURG Gene

  • The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. [provided by RefSeq, Apr 2016]

GeneCards Summary for PURG Gene

PURG (Purine Rich Element Binding Protein G) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is PURA.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PURG Gene

Genomics for PURG Gene

Regulatory Elements for PURG Gene

Enhancers for PURG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G030403 1.2 Ensembl ENCODE dbSUPER 5 +627.7 627663 6.1 CTCF ZSCAN4 RAD21 ZFHX2 POLR2A SMC3 FOS MAFK NFE2L2 EGR2 RBPMS-AS1 PURG GSR PIR31328
GH08G031033 1.5 FANTOM5 ENCODE 0.7 -0.7 -722 2.7 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 KCTD9P6 WRN UBXN8 PURG SUMO2P16
GH08G031049 0.5 FANTOM5 1.6 -15.9 -15922 0.3 PRDM6 ZBTB33 ATF2 TEX15 PURG SUMO2P16
GH08G031076 0.9 ENCODE 0.3 -41.9 -41918 0.7 ATF1 TBL1XR1 TCF12 ZNF766 GATA2 ZBTB11 CEBPB MBD2 KLF16 SMARCA4 PPP2CB PURG SUMO2P16
GH08G031075 0.7 ENCODE 0.3 -41.5 -41485 0.2 ZNF639 ATF1 RNF2 ZBTB11 PTTG1 DPF2 FOSL1 CTBP1 ZNF766 GATA3 PURG SUMO2P16
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PURG on UCSC Golden Path with GeneCards custom track

Promoters for PURG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000223155 -185 2201 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for PURG Gene

Chromosome:
8
Start:
30,995,802 bp from pter
End:
31,033,715 bp from pter
Size:
37,914 bases
Orientation:
Minus strand

Genomic View for PURG Gene

Genes around PURG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PURG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PURG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PURG Gene

Proteins for PURG Gene

  • Protein details for PURG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJV8-PURG_HUMAN
    Recommended name:
    Purine-rich element-binding protein gamma
    Protein Accession:
    Q9UJV8
    Secondary Accessions:
    • Q8TE64

    Protein attributes for PURG Gene

    Size:
    347 amino acids
    Molecular mass:
    39556 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PURG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PURG Gene

Post-translational modifications for PURG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PURG Gene

No data available for DME Specific Peptides for PURG Gene

Domains & Families for PURG Gene

Protein Domains for PURG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PURG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJV8

UniProtKB/Swiss-Prot:

PURG_HUMAN :
  • Belongs to the PUR DNA-binding protein family.
Family:
  • Belongs to the PUR DNA-binding protein family.
genes like me logo Genes that share domains with PURG: view

No data available for Gene Families for PURG Gene

Function for PURG Gene

Gene Ontology (GO) - Molecular Function for PURG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA 22681889
genes like me logo Genes that share ontologies with PURG: view

Phenotypes for PURG Gene

GenomeRNAi human phenotypes for PURG:
genes like me logo Genes that share phenotypes with PURG: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PURG Gene

Localization for PURG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PURG Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PURG gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PURG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PURG: view

Pathways & Interactions for PURG Gene

No Data Available

Interacting Proteins for PURG Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000418721%0d%0a9606.ENSP00000229030%0d%0a9606.ENSP00000345785%0d%0a9606.ENSP00000434034%0d%0a9606.ENSP00000351605%0d%0a9606.ENSP00000354607%0d%0a
Selected Interacting proteins: Q9UJV8-PURG_HUMAN ENSP00000418721 for PURG Gene via IID STRING

Gene Ontology (GO) - Biological Process for PURG Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PURG Gene

Drugs & Compounds for PURG Gene

No Compound Related Data Available

Transcripts for PURG Gene

mRNA/cDNA for PURG Gene

Unigene Clusters for PURG Gene

Purine-rich element binding protein G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PURG Gene

No ASD Table

Relevant External Links for PURG Gene

GeneLoc Exon Structure for
PURG
ECgene alternative splicing isoforms for
PURG

Expression for PURG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PURG Gene

mRNA differential expression in normal tissues according to GTEx for PURG Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.9) and Brain - Cerebellum (x5.7).

Protein differential expression in normal tissues from HIPED for PURG Gene

This gene is overexpressed in Plasma (57.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PURG Gene



Protein tissue co-expression partners for PURG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PURG Gene:

PURG

SOURCE GeneReport for Unigene cluster for PURG Gene:

Hs.373778

mRNA Expression by UniProt/SwissProt for PURG Gene:

Q9UJV8-PURG_HUMAN
Tissue specificity: Isoform 1 is expressed in testis and glioblastoma. Isoform 2 is expressed in fetal lung.

Evidence on tissue expression from TISSUES for PURG Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with PURG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PURG Gene

Orthologs for PURG Gene

This gene was present in the common ancestor of animals.

Orthologs for PURG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PURG 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia PURG 34 35
  • 95.97 (n)
rat
(Rattus norvegicus)
Mammalia Purg 34
  • 94.95 (n)
cow
(Bos Taurus)
Mammalia PURG 34 35
  • 93.84 (n)
mouse
(Mus musculus)
Mammalia Purg 34 16 35
  • 93.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PURG 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PURG 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PURG 34 35
  • 81.94 (n)
lizard
(Anolis carolinensis)
Reptilia PURG 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia purg 34
  • 74 (n)
zebrafish
(Danio rerio)
Actinopterygii purg 34 35
  • 68.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pur-alpha 36 35
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea plp-1 35
  • 34 (a)
ManyToMany
plp-2 35
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToMany
Species where no ortholog for PURG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PURG Gene

ENSEMBL:
Gene Tree for PURG (if available)
TreeFam:
Gene Tree for PURG (if available)

Paralogs for PURG Gene

Paralogs for PURG Gene

(2) SIMAP similar genes for PURG Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PURG: view

Variants for PURG Gene

Sequence variations from dbSNP and Humsavar for PURG Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_036317 A breast cancer sample
rs11574156 Likely benign 31,033,642(+) GCCTC(C/T)ACGCA upstream-variant-2KB, utr-variant-5-prime
rs11574157 Likely benign 31,033,772(+) ACGGC(C/G)CTGGA upstream-variant-2KB, utr-variant-5-prime
rs11574158 Likely benign 31,033,837(+) GCGCC(A/G)GCTTG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs11574160 Likely benign 31,033,887(+) CTAGC(C/G)TGGAT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PURG Gene

Variant ID Type Subtype PubMed ID
esv22033 CNV loss 19812545
nsv1133688 CNV deletion 24896259
nsv1145194 CNV deletion 24896259
nsv527651 CNV loss 19592680

Variation tolerance for PURG Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PURG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PURG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PURG Gene

Disorders for PURG Gene

Relevant External Links for PURG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PURG

No disorders were found for PURG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PURG Gene

Publications for PURG Gene

  1. Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation. (PMID: 12034829) Liu H. … Johnson E.M. (Nucleic Acids Res. 2002) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3 64
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3 64
  5. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L. … Green M.R. (PLoS Genet. 2012) 3 64

Products for PURG Gene

Sources for PURG Gene

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