PURG Gene
protein-coding GIFtS: 44
GCID: GC08M030853
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|
purine-rich element binding protein G
| |
Aliases
for PURG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Purine-Rich Element Binding Protein G1 2 | | PURG-A1 2 | | PURG-B1 2 | | Pur-Gamma1 | | Purine-Rich Element-Binding Protein Gamma2 |
Export aliases for PURG gene to outside databasesPrevious GC identifers: GC08M030758 GC08M031340 GC08M030946 GC08M030911 GC08M030972 GC08M029398 |
Summaries
for PURG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PURG:
The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich elementbinding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of thepurine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. Thisgene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. Twotranscript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
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Genomic Views
for PURG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PURG gene promoter:
SRY p300 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for PURG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PURG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p11 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p11PURG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M030853: view genomic region
(about GC identifiers)
Start:
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30,853,321 bp from pter |
End:
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30,891,231 bp from pter |
Size:
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37,911 bases |
Orientation:
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minus strand |
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Proteins
for PURG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PURG_HUMAN, Q9UJV8 (See
protein sequence)Recommended Name: Purine-rich element-binding protein gamma Size: 347 amino acids; 39556 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q8TE64Alternative splicing: 2 isoforms: Q9UJV8-1 Q9UJV8-2 Explore the universe of human proteins at neXtProt for PURG: NX_Q9UJV8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UJV8
PURG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001015508.1 NP_037489.1
ENSEMBL proteins: ENSP00000345168 ENSP00000418721 ENSP00000466881
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
PURG for ontologies About GeneDecksing
PURG Antibody Products:
Assay Products for PURG: |
Protein
Domains /
Families
for PURG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PURG for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UJV8ProtoNet protein and cluster: Q9UJV8 UniProtKB/Swiss-Prot: PURG_HUMAN, Q9UJV8Similarity: Belongs to the PUR DNA-binding protein family |
Function
for PURG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PURG (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PURG (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PURG (NM_001015508) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PURG | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PURG |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PURG |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
PURG for ontologies About GeneDecksing
|
Pathways & Interactions
for PURG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PURG
|
Drugs & Compounds
for PURG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PURG
Search CenterWatch for drugs/clinical trials and news about PURG
|
Transcripts
for PURG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PURG gene (2 alternative transcripts): NM_001015508.1 NM_013357.2 Unigene Cluster for PURG: Purine-rich element binding protein G Hs.373778 [show with all ESTs]Unigene Representative Sequence: AF1955133 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000339382(uc003xim.1) ENST00000475541(uc003xin.3) ENST00000523392
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PURG (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PURG (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PURG (NM_001015508) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PURG | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PURG |
Additional cDNA sequence: AF195513.2 AY077841.1 BC106708.2 5 DOTS entries: DT.97787038 DT.212373 DT.121484640 DT.305925 DT.425123 19 AceView cDNA sequences: NM_013357 AY077841 BX108802 AI338787 AF195513 AW273712 BX477758 BX489006 BE503391 BI550191 AI369980 BF245424 BE837484 AW170055 AW085294 AA598938 N53362 AA598766 N90845
GeneLoc Exon Structure
|
Expression
for PURG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PURG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAACAAAG
About this image
See PURG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PURG
SOURCE GeneReport for Unigene cluster: Hs.373778
UniProtKB/Swiss-Prot: PURG_HUMAN, Q9UJV8Tissue specificity: Isoform 1 is expressed in testis and glioblastoma. Isoform 2 is expressed in fetal lung
SABiosciences Custom PCR Arrays for PURG
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PURG
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PURG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PURG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PURG | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PURG |
Orthologs
for PURG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PURG gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PURG1 |
purine-rich element binding protein G |
81.25(n)
87.2(a) |
|
428737 XM_426295.3 XP_426295.3 |
lizard
(Anolis carolinensis) |
Reptilia |
PURG6 |
-- |
88(a) |
1 ↔ 1 |
GL343257.1(439921-440919) |
zebrafish
(Danio rerio) |
Actinopterygii |
purg1 |
purine-rich element binding protein G |
67.26(n)
72.7(a) |
|
569414 XM_692797.3 XP_697889.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pur-alpha3 |
single-stranded DNA binding |
41(a) |
|
102C2 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
plp-16plp-26 |
Protein PLP-2 |
31(a)22(a) |
many ↔ manymany ↔ many |
IV(7633342-7634646) X(14982070-14982734) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PUR ALPHA-16 |
transcription factor Pur-alpha 1 |
24(a) |
1 → many |
2(13642237-13644166) |
rice
(Oryza sativa) |
Liliopsida |
-- |
PUR ALPHA-1, putative, expressed |
21(a) |
1 → many |
1(8758370-8762491) |
ENSEMBL Gene Tree for PURG (if available)
TreeFam Gene Tree for PURG (if available) |
Paralogs
for PURG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PURG gene
- PURB2 PURA2
2 SIMAP similar genes for PURG using alignment to 3 protein entries: PURG_HUMAN (see all proteins):PURB PURA
PURG for paralogs About GeneDecksing
|
Genomic Variants
for PURG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PURG (30853321 - 30891231 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PURG
1 CNV: 65103 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PURG |
|
Disorders
/ Diseases
for PURG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PURG for disorders About GeneDecksing
2  diseases for PURG: About MalaCardswerner syndrome glioblastoma
1 disease from the University of Copenhagen DISEASES database for PURG:Werner syndrome Export disorders for PURG gene to outside databases
|
Publications
for PURG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PURG gene integrated from 9 sources:
(articles sorted by number of sources associating them with PURG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation. (PubMed id 12034829)1, 2, 3 Liu H. and Johnson E.M. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for PURG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing PURG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PURG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PURG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PURG | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PURG gene:
Search GeneIP for patents involving PURG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PURG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PURG | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PURG | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PURG | | | OriGene Protein Over-expression Lysate for PURG | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PURG | | OriGene 3'-UTR Clone for PURG | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PURG | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PURG | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PURG | | OriGene Custom Protein Services for PURG | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PURG | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PURG | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PURG | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PURG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PURG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PURG |
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 |  |  |  | |
| | | | Search Tocris compounds for PURG |
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 | | | PURG Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PURG |
|  |  |  | | | | ThermoFisher Antibodies for PURG |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PURG |
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