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Aliases for PURG Gene

Aliases for PURG Gene

  • Purine-Rich Element Binding Protein G 2 3
  • Purine-Rich Element-Binding Protein Gamma 3
  • Pur-Gamma 3
  • PURG-A 3
  • PURG-B 3

External Ids for PURG Gene

Summaries for PURG Gene

Entrez Gene Summary for PURG Gene

  • The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PURG Gene

PURG (Purine-Rich Element Binding Protein G) is a Protein Coding gene. An important paralog of this gene is PURB.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PURG Gene

Genomics for PURG Gene

Genomic Location for PURG Gene

Start:
30,995,802 bp from pter
End:
31,033,715 bp from pter
Size:
37,914 bases
Orientation:
Minus strand

Genomic View for PURG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PURG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PURG Gene

Regulatory Elements for PURG Gene

Proteins for PURG Gene

  • Protein details for PURG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJV8-PURG_HUMAN
    Recommended name:
    Purine-rich element-binding protein gamma
    Protein Accession:
    Q9UJV8
    Secondary Accessions:
    • Q8TE64

    Protein attributes for PURG Gene

    Size:
    347 amino acids
    Molecular mass:
    39556 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PURG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PURG Gene

Proteomics data for PURG Gene at MOPED

Post-translational modifications for PURG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PURG Gene

No data available for DME Specific Peptides for PURG Gene

Domains for PURG Gene

Protein Domains for PURG Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PURG_HUMAN
Family:
  • Belongs to the PUR DNA-binding protein family.:
    • Q9UJV8
genes like me logo Genes that share domains with PURG: view

No data available for Gene Families for PURG Gene

Function for PURG Gene

Gene Ontology (GO) - Molecular Function for PURG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with PURG: view

miRNA for PURG Gene

miRTarBase miRNAs that target PURG

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PURG Gene

Localization for PURG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PURG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PURG Gene COMPARTMENTS Subcellular localization image for PURG gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PURG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PURG: view

Pathways for PURG Gene

SuperPathways for PURG Gene

No Data Available

Interacting Proteins for PURG Gene

Gene Ontology (GO) - Biological Process for PURG Gene

None

No data available for Pathways by source for PURG Gene

Transcripts for PURG Gene

mRNA/cDNA for PURG Gene

Unigene Clusters for PURG Gene

Purine-rich element binding protein G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PURG Gene

No ASD Table

Relevant External Links for PURG Gene

GeneLoc Exon Structure for
PURG
ECgene alternative splicing isoforms for
PURG

Expression for PURG Gene

mRNA expression in normal human tissues for PURG Gene

mRNA differential expression in normal tissues according to GTEx for PURG Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.9) and Brain - Cerebellum (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PURG Gene

SOURCE GeneReport for Unigene cluster for PURG Gene Hs.373778

mRNA Expression by UniProt/SwissProt for PURG Gene

Q9UJV8-PURG_HUMAN
Tissue specificity: Isoform 1 is expressed in testis and glioblastoma. Isoform 2 is expressed in fetal lung.
genes like me logo Genes that share expressions with PURG: view

Orthologs for PURG Gene

This gene was present in the common ancestor of animals.

Orthologs for PURG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PURG 36
  • 100 (n)
  • 100 (a)
PURG 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PURG 36
  • 93.84 (n)
  • 97.58 (a)
PURG 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PURG 36
  • 95.97 (n)
  • 97.98 (a)
PURG 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Purg 36
  • 93.84 (n)
  • 96.97 (a)
Purg 16
Purg 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PURG 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PURG 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Purg 36
  • 94.95 (n)
  • 97.88 (a)
chicken
(Gallus gallus)
Aves PURG 36
  • 81.94 (n)
  • 87.62 (a)
PURG 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PURG 37
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia purg 36
  • 74 (n)
  • 84.79 (a)
zebrafish
(Danio rerio)
Actinopterygii purg 36
  • 68.17 (n)
  • 75.56 (a)
purg 37
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pur-alpha 37
  • 41 (a)
OneToMany
Pur-alpha 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea plp-1 37
  • 34 (a)
ManyToMany
plp-2 37
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
OneToMany
Species with no ortholog for PURG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PURG Gene

ENSEMBL:
Gene Tree for PURG (if available)
TreeFam:
Gene Tree for PURG (if available)

Paralogs for PURG Gene

Paralogs for PURG Gene

Selected SIMAP similar genes for PURG Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PURG: view

Variants for PURG Gene

Sequence variations from dbSNP and Humsavar for PURG Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1125841 -- 31,000,538(+) GATTA(C/T)GATTC intron-variant
rs1362910 -- 30,998,948(+) TCTAT(A/G)TTGGT intron-variant
rs1362911 -- 31,007,428(+) ACATA(A/C)TCTTA intron-variant
rs1421334 -- 31,008,217(+) GAAGA(A/C)TTAAT intron-variant
rs2241300 -- 30,995,952(+) AAAGC(A/G)CCATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PURG Gene

Variant ID Type Subtype PubMed ID
nsv890705 CNV Gain 21882294
nsv527651 CNV Loss 19592680
esv22033 CNV Loss 19812545
nsv890706 CNV Loss 21882294

Relevant External Links for PURG Gene

HapMap Linkage Disequilibrium report
PURG

Disorders for PURG Gene

(1) University of Copenhagen DISEASES for PURG Gene

genes like me logo Genes that share disorders with PURG: view

No data available for UniProtKB/Swiss-Prot for PURG Gene

Publications for PURG Gene

  1. Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation. (PMID: 12034829) Liu H. … Johnson E.M. (Nucleic Acids Res. 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3
  4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3
  5. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3

Products for PURG Gene

Sources for PURG Gene

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