Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PURB Gene

Aliases for PURB Gene

  • Purine-Rich Element Binding Protein B 2 3 5
  • Purine-Rich Element-Binding Protein B 3 4
  • PURBETA 3

External Ids for PURB Gene

Previous GeneCards Identifiers for PURB Gene

  • GC07M044570
  • GC07M044664
  • GC07M044656
  • GC07M044689
  • GC07M044882
  • GC07M044801

Summaries for PURB Gene

Entrez Gene Summary for PURB Gene

  • This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for PURB Gene

PURB (Purine-Rich Element Binding Protein B) is a Protein Coding gene. Diseases associated with PURB include myelodysplastic syndrome. GO annotations related to this gene include poly(A) RNA binding and RNA binding. An important paralog of this gene is PURA.

UniProtKB/Swiss-Prot for PURB Gene

  • Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity).

Gene Wiki entry for PURB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PURB Gene

Genomics for PURB Gene

Regulatory Elements for PURB Gene

Promoters for PURB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PURB on UCSC Golden Path with GeneCards custom track

Genomic Location for PURB Gene

Chromosome:
7
Start:
44,876,293 bp from pter
End:
44,885,385 bp from pter
Size:
9,093 bases
Orientation:
Minus strand

Genomic View for PURB Gene

Genes around PURB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PURB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PURB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PURB Gene

Proteins for PURB Gene

  • Protein details for PURB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QR8-PURB_HUMAN
    Recommended name:
    Transcriptional activator protein Pur-beta
    Protein Accession:
    Q96QR8
    Secondary Accessions:
    • A4D2L7

    Protein attributes for PURB Gene

    Size:
    312 amino acids
    Molecular mass:
    33241 Da
    Quaternary structure:
    • Homodimer, heterodimer with PURA and heterotrimer with PURA and YBX1/Y-box protein 1.
    Miscellaneous:
    • Defects in PURB may be a cause of progression of myelodysplastic syndrome (MDS) towards acute myelogenous leukemia (AML). MDS refers to a heterogeneous group of closely related hematopoietic disorders. All are characterized by a cellular marrow with impaired morphology and maturation (dysmyelopoiesis) and peripheral blood cytopenias, resulting from ineffective blood cell production. Some patients with MDS develop acute myelogenous leukemia (AML), a malignant disease in which hematopoietic precursors are arrested in an early stage of development.

neXtProt entry for PURB Gene

Proteomics data for PURB Gene at MOPED

Post-translational modifications for PURB Gene

  • Ubiquitination at Lys 240
  • Modification sites at PhosphoSitePlus

Other Protein References for PURB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PURB Gene

Domains & Families for PURB Gene

Protein Domains for PURB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PURB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QR8

UniProtKB/Swiss-Prot:

PURB_HUMAN :
  • Belongs to the PUR DNA-binding protein family.
Family:
  • Belongs to the PUR DNA-binding protein family.
genes like me logo Genes that share domains with PURB: view

No data available for Gene Families for PURB Gene

Function for PURB Gene

Molecular function for PURB Gene

UniProtKB/Swiss-Prot Function:
Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity).

Gene Ontology (GO) - Molecular Function for PURB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003697 single-stranded DNA binding IEA,ISS --
GO:0003729 mRNA binding IEA,ISS --
GO:0005515 protein binding IEA --
GO:0008134 transcription factor binding IEA,ISS --
genes like me logo Genes that share ontologies with PURB: view

Phenotypes for PURB Gene

genes like me logo Genes that share phenotypes with PURB: view

Animal Model Products

miRNA for PURB Gene

miRTarBase miRNAs that target PURB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PURB Gene

Localization for PURB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PURB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PURB Gene COMPARTMENTS Subcellular localization image for PURB gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for PURB Gene

Pathways & Interactions for PURB Gene

SuperPathways for PURB Gene

No Data Available

Gene Ontology (GO) - Biological Process for PURB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with PURB: view

No data available for Pathways by source and SIGNOR curated interactions for PURB Gene

Drugs & Compounds for PURB Gene

No Compound Related Data Available

Transcripts for PURB Gene

mRNA/cDNA for PURB Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(320) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PURB Gene

Purine-rich element binding protein B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PURB Gene

No ASD Table

Relevant External Links for PURB Gene

GeneLoc Exon Structure for
PURB
ECgene alternative splicing isoforms for
PURB

Expression for PURB Gene

mRNA expression in normal human tissues for PURB Gene

Protein differential expression in normal tissues from HIPED for PURB Gene

This gene is overexpressed in Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PURB Gene



SOURCE GeneReport for Unigene cluster for PURB Gene Hs.349150

mRNA Expression by UniProt/SwissProt for PURB Gene

Q96QR8-PURB_HUMAN
Tissue specificity: Expressed in myocardium of heart failure patients.
genes like me logo Genes that share expression patterns with PURB: view

Protein tissue co-expression partners for PURB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PURB Gene

Orthologs for PURB Gene

This gene was present in the common ancestor of animals.

Orthologs for PURB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PURB 35
  • 89.71 (n)
  • 96.84 (a)
PURB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia H2AFV 35
  • 88.7 (n)
  • 93.96 (a)
mouse
(Mus musculus)
Mammalia Purb 35
  • 93.49 (n)
  • 97.98 (a)
Purb 16
Purb 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PURB 35
  • 99.36 (n)
  • 99.68 (a)
PURB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Purb 35
  • 93.04 (n)
  • 98.32 (a)
oppossum
(Monodelphis domestica)
Mammalia PURB 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PURB 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495008 35
  • 79.61 (n)
  • 88.28 (a)
Str.11973 35
zebrafish
(Danio rerio)
Actinopterygii purbb 35
  • 80.23 (n)
  • 87.6 (a)
zgc65916 35
purba 36
  • 80 (a)
OneToMany
purbb 36
  • 82 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9781 35
fruit fly
(Drosophila melanogaster)
Insecta Pur-alpha 37
  • 44 (a)
Pur-alpha 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea plp-1 36
  • 38 (a)
ManyToMany
plp-2 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for PURB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PURB Gene

ENSEMBL:
Gene Tree for PURB (if available)
TreeFam:
Gene Tree for PURB (if available)

Paralogs for PURB Gene

Paralogs for PURB Gene

(2) SIMAP similar genes for PURB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PURB: view

Variants for PURB Gene

Sequence variations from dbSNP and Humsavar for PURB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs8840 -- 44,877,441(-) ACTTA(C/T)AAAGA utr-variant-3-prime
rs9701 -- 44,879,601(+) GACAG(A/G)AAAGA utr-variant-3-prime
rs15555 -- 44,879,850(+) ATCAA(A/G)AAGTG utr-variant-3-prime
rs763414 -- 44,884,588(+) TGCGG(G/T)AGGAC reference, missense
rs1990053 -- 44,886,297(+) CCAGA(A/G)ATCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PURB Gene

Variant ID Type Subtype PubMed ID
nsv830985 CNV Loss 17160897
nsv888000 CNV Loss 21882294

Variation tolerance for PURB Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PURB Gene

HapMap Linkage Disequilibrium report
PURB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PURB Gene

Disorders for PURB Gene

MalaCards: The human disease database

(1) MalaCards diseases for PURB Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myelodysplastic syndrome
  • myelodysplastic syndrome, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PURB in MalaCards View complete list of genes associated with diseases

Relevant External Links for PURB

Genetic Association Database (GAD)
PURB
Human Genome Epidemiology (HuGE) Navigator
PURB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PURB
genes like me logo Genes that share disorders with PURB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PURB Gene

Publications for PURB Gene

  1. Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein. (PMID: 1448097) Bergemann A.D. … Johnson E.M. (Mol. Cell. Biol. 1992) 2 3 4 67
  2. Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure. (PMID: 12933792) Gupta M. … Gupta M.P. (J. Biol. Chem. 2003) 3 23
  3. Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia. (PMID: 11417483) Lezon-Geyda K. … Johnson E.M. (Leukemia 2001) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PURB Gene

Sources for PURB Gene

Back to Top

Content