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PURA Gene

protein-coding   GIFtS: 63
GCID: GC05P139473

Purine-Rich Element Binding Protein A

  See PURA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Purine-Rich Element Binding Protein A1 2
PUR12 3 5
Purine-Rich Single-Stranded DNA-Binding Protein Alpha2 3
PUR-ALPHA2
PURALPHA2
Transcriptional Activator Protein Pur-Alpha2

External Ids:    HGNC: 97011   Entrez Gene: 58132   Ensembl: ENSG000001851297   OMIM: 6004735   UniProtKB: Q005773   
ORGUL members:         

Export aliases for PURA gene to outside databases

Previous GC identifers: GC05P139316 GC05P140076 GC05P139476 GC05P139522 GC05P134636


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PURA Gene:
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the
single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene
flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of
both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome
and acute myelogenous leukemia. (provided by RefSeq, Jul 2008)

GeneCards Summary for PURA Gene:
PURA (purine-rich element binding protein A) is a protein-coding gene. Diseases associated with PURA include tick-borne relapsing fever, and relapsing fever. GO annotations related to this gene include single-stranded DNA binding and transcription factor binding. An important paralog of this gene is PURG.

UniProtKB/Swiss-Prot: PURA_HUMAN, Q00577
Function: This is a probable transcription activator that specifically binds the purine-rich single strand of the
PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in
recombination

Gene Wiki entry for PURA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the PURA gene promoter:
         E2F-3a   Oct-B1   E2F-4   Max1   E2F-5   Sp1   Egr-1   Max   MZF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PURA promoter sequence
   Search Chromatin IP Primers for PURA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PURA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31

PURA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PURA gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P139473:  view genomic region     (about GC identifiers)

Start:
139,487,362 bp from pter      End:
139,499,001 bp from pter
Size:
11,640 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PURA_HUMAN, Q00577 (See protein sequence)
Recommended Name: Transcriptional activator protein Pur-alpha  
Size: 322 amino acids; 34911 Da
Subunit: Homodimer, heterodimer with PURB and heterotrimer with PURB and YBX1/Y-box protein 1 (By similarity)

Explore the universe of human proteins at neXtProt for PURA: NX_Q00577

Explore proteomics data for PURA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys229, Lys239, Lys262
  • Modification sites at PhosphoSitePlus

  • See PURA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005850.1  
    ENSEMBL proteins: 
     ENSP00000332706  

    PURA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PURA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PURA
    GenScript Custom Purified and Recombinant Proteins Services for PURA
    Novus Biologicals PURA Proteins
    Novus Biologicals PURA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PURA

     
    Search eBioscience for Proteins for PURA 

     
    antibodies-online proteins for PURA (7 products) 

     
    antibodies-online peptides for PURA

    PURA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PURA
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PURA
    Novus Biologicals PURA Antibodies
    Abcam antibodies for PURA
    Cloud-Clone Corp. Antibodies for PURA
    ThermoFisher Antibodies for PURA
    antibodies-online antibodies for PURA (29 products) 

    PURA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PURA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PURA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PURA
    Cloud-Clone Corp. CLIAs for PURA
    Search eBioscience for ELISAs for PURA 
    antibodies-online kits for PURA (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006628 PUR_DNA_RNA-bd

    Graphical View of Domain Structure for InterPro Entry Q00577

    ProtoNet protein and cluster: Q00577

    UniProtKB/Swiss-Prot: PURA_HUMAN, Q00577
    Similarity: Belongs to the PUR DNA-binding protein family


    Find genes that share domains with PURA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PURA_HUMAN, Q00577
    Function: This is a probable transcription activator that specifically binds the purine-rich single strand of the
    PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in
    recombination

         Genatlas biochemistry entry for PURA:
    single-stranded DNA binding protein A with specific affinity for a purine-rich element (GGN)n

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000900translation repressor activity, nucleic acid binding IEA--
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding ----
    GO:0003691double-stranded telomeric DNA binding IDA15777841
    GO:0003697single-stranded DNA binding ISS--
         
    Find genes that share ontologies with PURA           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PURA:
     Decreased Tat-dependent transc  Decreased p24 protein expressi 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pura):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  respiratory system 

    Find genes that share phenotypes with PURA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PURA: Puratm1Herm Puratm1Kkh

       genOway: Develop your customized and physiologically relevant rodent model for PURA

    miRNA
    Products:
        
    miRTarBase miRNAs that target PURA:
    hsa-mir-20a-5p (MIRT007002), hsa-mir-103a-3p (MIRT027227), hsa-mir-484 (MIRT042016), hsa-mir-15b-5p (MIRT007001), hsa-mir-15a-5p (MIRT006998), hsa-mir-21-5p (MIRT031011), hsa-mir-16-5p (MIRT001425), hsa-mir-192-5p (MIRT026791), hsa-mir-93-5p (MIRT007003), hsa-mir-106b-5p (MIRT007004)

    Block miRNA regulation of human, mouse, rat PURA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PURA (see all 137):
    hsa-miR-106a hsa-miR-3162-5p hsa-miR-374b* hsa-miR-130a* hsa-miR-23c hsa-miR-587 hsa-miR-199a-5p hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidPURA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PURA
    Predesigned siRNA for gene silencing in human, mouse, rat PURA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PURA

    Clone
    Products:
         
    OriGene clones in human, mouse for PURA (see all 6)
    OriGene ORF clones in mouse, rat for PURA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PURA (NM_005859)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PURA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PURA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PURA
    Browse ESI BIO Cell Lines and PureStem Progenitors for PURA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PURA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PURA_HUMAN, Q00577: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000784nuclear chromosome, telomeric region IC15777841
    GO:0005634nucleus IDA9716182
    GO:0005662DNA replication factor A complex ISS--
    GO:0005737cytoplasm IEA--
    GO:0030425dendrite IEA--

    Find genes that share ontologies with PURA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PURA About    
    See pathways by source

    SuperPathContained pathways About
    1Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    1 BioSystems Pathway for PURA
        Diurnally regulated genes with circadian orthologs


        Pathway & Disease-focused RT2 Profiler PCR Array including PURA: 
              Telomeres & Telomerase in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PURA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PURA (Q005771, 2, 3 ENSP000003327064) via UniProtKB, MINT, STRING, and/or I2D (see all 634)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNT1O605632, 3, ENSP000002619004MINT-7945693 I2D: score=3 STRING: ENSP00000261900
    CDK1P064932, 3MINT-7945693 I2D: score=1 
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006268DNA unwinding involved in DNA replication IDA15777841
    GO:0006270DNA replication initiation TAS1545807
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9334258
    GO:0006366transcription from RNA polymerase II promoter TAS9334258
    GO:0007399nervous system development IEA--

    Find genes that share ontologies with PURA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PURA

    1 Novoseek inferred chemical compound relationship for PURA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 0 3 11169743 (1), 10412036 (1)



    Find genes that share compounds with PURA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PURA gene: 
    NM_005859.4  

    Unigene Cluster for PURA:

    Purine-rich element binding protein A
    Hs.443121  [show with all ESTs]
    Unigene Representative Sequence: NM_005859
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505703 ENST00000502351 ENST00000331327(uc003lfa.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PURA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PURA (see all 137):
    hsa-miR-106a hsa-miR-3162-5p hsa-miR-374b* hsa-miR-130a* hsa-miR-23c hsa-miR-587 hsa-miR-199a-5p hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidPURA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PURA
    Predesigned siRNA for gene silencing in human, mouse, rat PURA
    Clone
    Products:
         
    OriGene clones in human, mouse for PURA (see all 6)
    OriGene ORF clones in mouse, rat for PURA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PURA (NM_005859)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PURA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PURA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PURA
    OriGene qSTAR qPCR primer pairs in human, mouse for PURA
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PURA
      QuantiTect SYBR Green Assays in human, mouse, rat PURA
      QuantiFast Probe-based Assays in human, mouse, rat PURA

    Additional mRNA sequence: 

    BC036087.1 BT019388.1 M96684.1 X91648.1 

    6 DOTS entries:

    DT.214739  DT.99950612  DT.95270869  DT.40220224  DT.95363147  DT.99966679 

    Selected AceView cDNA sequences (see all 175):

    BM838095 AA917312 BU071103 AI201454 CB104985 AA243402 AA781006 CB157501 
    AI417720 BM509783 AW779289 BU782613 AI758620 BM986975 BM667443 AA813909 
    BE221754 BU783599 BM505371 AW614475 AI972176 BM698528 AW084098 CD677455 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PURA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATACACACA
    PURA Expression
    About this image


    PURA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    PURA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PURA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443121
        Pathway & Disease-focused RT2 Profiler PCR Array including PURA: 
              Telomeres & Telomerase in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PURA
    OriGene qSTAR qPCR primer pairs in human, mouse for PURA
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PURA
    QuantiTect SYBR Green Assays in human, mouse, rat PURA
    QuantiFast Probe-based Assays in human, mouse, rat PURA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PURA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PURA gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pura1 , 5 purine rich element binding protein A1, 5 95.74(n)1
    98.72(a)1
      18 (19.46 cM)5
    192901  NM_008989.31  NP_033015.11 
     362810975 
    chicken
    (Gallus gallus)
    Aves PURB1 purine-rich element binding protein B 92.51(n)
    96.48(a)
      430546  XM_003642042.2  XP_003642090.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pura1 purine-rich element binding protein A 82.91(n)
    96.64(a)
      100135162  NM_001113869.1  NP_001107341.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pura1 purine-rich element binding protein A 84.18(n)
    96.61(a)
      415106  NM_001001846.1  NP_001001846.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pur-alpha3 single-stranded DNA binding 48(a)   102C2   --
    worm
    (Caenorhabditis elegans)
    Secernentea plp-16
    plp-26
    Protein PLP-2 (plp-2) mRNA, complete cds
    35(a)
    28(a)
    many ↔ many
    many ↔ many
    IV(7633360-7634657) WBGene00004046
    X(14982140-14982804) WBGene00008976


    ENSEMBL Gene Tree for PURA (if available)
    TreeFam Gene Tree for PURA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PURA gene
    PURG2  PURB2  
    2 SIMAP similar genes for PURA using alignment to 4 protein entries:     PURA_HUMAN (see all proteins):
    PURB    PURG

    Find genes that share paralogs with PURA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PURA (see all 94)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1448061611,2
    --139491817(+) TGTCCA/CTCGGG 1 -- us2k10--------
    rs1479372651,2
    --139491856(+) CTTTTG/TGGGGA 1 -- us2k10--------
    rs1826542021,2
    --139491884(+) GGGAAC/TAGAAC 1 -- us2k10--------
    rs1877805191,2
    --139491975(+) TCTGTA/GTCTCT 1 -- us2k10--------
    rs1393950511,2
    --139492018(+) TGGGCA/GCATTG 1 -- us2k10--------
    rs2007207141,2
    --139492026(+) TTGGC-/AGGGGG 1 -- us2k10--------
    rs1925323541,2
    --139492046(+) GGAGAA/TAGGCC 1 -- us2k10--------
    rs8755751,2
    C,F,A,H--139492065(+) CCCCAG/CAGTGC 1 -- us2k119Minor allele frequency- C:0.25MN NS EA NA WA CSA 1469
    rs1500656481,2
    --139492099(+) GAGTAA/CAAGCA 1 -- us2k10--------
    rs1167743401,2
    C,F--139492221(+) TTTTTA/CGCTAT 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for PURA (139487362 - 139499001 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PURA: --
    Human Gene Mutation Database (HGMD): PURA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PURA
    DNA2.0 Custom Variant and Variant Library Synthesis for PURA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600473    OMIM disorders: --

    4 diseases for PURA:    
    About MalaCards
    tick-borne relapsing fever    relapsing fever    bladder neck obstruction    urethral intrinsic sphincter deficiency

    3 diseases from the University of Copenhagen DISEASES database for PURA:
    Bladder neck obstruction     tick-borne relapsing fever     Urethral intrinsic sphincter deficiency

    Find genes that share disorders with PURA           About GenesLikeMe

    4 Novoseek inferred disease relationships for PURA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 36.3 6 11413364 (2), 8943069 (1), 10412036 (1), 15684713 (1) (see all 5)
    myeloid leukemia 33.4 2 10954586 (1)
    neurodegeneration 12.4 1 17698009 (1)
    cancer 0 5 10954586 (1), 18927497 (1)

    Genetic Association Database (GAD): PURA
    Human Genome Epidemiology (HuGE) Navigator: PURA (2 documents)

    Export disorders for PURA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PURA gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with PURA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein. (PubMed id 1448097)1, 2, 3, 9 Bergemann A.D.... Johnson E.M. (Mol. Cell. Biol. 1992)
    2. Self-association of Puralpha is mediated by RNA. (PubMed id 10412036)1, 9 Gallia G.L....Khalili K. (J. Cell. Biochem. 1999)
    3. Interaction of the single-stranded DNA-binding protein Puralpha with the human polyomavirus JC virus early protein T-antigen. (PubMed id 9830007)1, 9 Gallia G.L....Khalili K. (J. Biol. Chem. 1998)
    4. Puralpha: a multifunctional single-stranded DNA- and RNA-binding protein. (PubMed id 10954586)1, 9 Gallia G.L....Khalili K. (Nucleic Acids Res. 2000)
    5. Purine-rich element binding protein (PUR) alpha induces endoplasmic reticulum stress response, and cell differentiation pathways in prostate cancer cells. (PubMed id 19267365)1, 9 Inoue T....Getzenberg R.H. (Prostate 2009)
    6. Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells. (PubMed id 10082537)1, 9 Safak M....Khalili K. (Mol. Cell. Biol. 1999)
    7. Functional interaction between cyclin T1/cdk9 and Puralpha determines the level of TNFalpha promoter activation by Tat in glial cells. (PubMed id 11730934)1, 9 Darbinian N....Amini S. (J. Neuroimmunol. 2001)
    8. Helix-destabilizing properties of the human single-stranded DNA- and RNA-binding protein Puralpha. (PubMed id 11169743)1, 9 Darbinian N....Khalili K. (J. Cell. Biochem. 2001)
    9. Interaction of HIV-1 Tat with Puralpha in nuclei of human glial cells: characterization of RNA-mediated protein-protein binding. (PubMed id 10679817)1, 9 Wortman M.J....Johnson E.M. (J. Cell. Biochem. 2000)
    10. Puralpha as a cellular co-factor of Rev/RRE-mediated expression of HIV-1 intron-containing mRNA. (PubMed id 17722108)1, 9 Kaminski R....Darbinyan A. (J. Cell. Biochem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5813 HGNC: 9701 AceView: PURA Ensembl:ENSG00000185129 euGenes: HUgn5813
    ECgene: PURA H-InvDB: PURA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PURA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PURA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PURA gene:
    Search GeneIP for patents involving PURA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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