Aliases for PUM2 Gene
External Ids for PUM2 Gene
Previous GeneCards Identifiers for PUM2 Gene
This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for PUM2 Gene
PUM2 (Pumilio RNA-Binding Family Member 2) is a Protein Coding gene. Among its related pathways are Translational Control. GO annotations related to this gene include RNA binding. An important paralog of this gene is PUM1.
UniProtKB/Swiss-Prot for PUM2 Gene
Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3-UTR of mRNA targets. Binds to an RNA consensus sequence, called Pumilio Response Element (PRE), 5-UGUANAUA-3, that is related to the Nanos Response Element (NRE). May regulate DCUN1D3 mRNA levels (PubMed:25349211). Capable of deadenylation-dependent and -independent modes of repression. May support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.