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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PUM2 Gene

protein-coding GIFtS: 61
GCID: GC02M020448

pumilio homolog 2 (Drosophila)

(Previous name: pumilio (Drosphila) homolog 2 )

Explore 9 diseases affiliated with
PUM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Pumilio Homolog 2 (Drosophila)¹ ²		PUML2²
PUMH2¹ ² ³		Pumilio Homolog 2²
KIAA0235¹ ³ ⁵		Pumilio-2³
Pumilio (Drosphila) Homolog 2¹		Pumilio-2³

External Ids:	HGNC: 14958¹	Entrez Gene: 23369²	Ensembl: ENSG00000055917⁷	OMIM: 607205⁵	UniProtKB: Q8TB72³

Export aliases for PUM2 gene to outside databases

Previous GC identifers: GC02M020339 GC02M020516 GC02M020416 GC02M020432 GC02M020370 GC02M020311 GC02M020205

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PUM2_HUMAN, Q8TB72

Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of

mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and

self-renewal of stem cells by regulating the translation of key transcripts

Gene Wiki entry for PUM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_015926.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PUM2 gene promoter:
TBP SRF Pbx1a SRF (504 AA) CUTL1 HNF-3beta Gfi-1 POU2F1 POU2F1a FOXO4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PUM2 promoter sequence

Search SABiosciences Chromatin IP Primers for PUM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PUM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22-p21 Ensembl cytogenetic band: 2p24.1 HGNC cytogenetic band: 2p22-p21

PUM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PUM2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M020448: view genomic region (about GC identifiers)

Start:	20,448,452 bp from pter	End:	20,551,995 bp from pter
Size:	103,544 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PUM2_HUMAN, Q8TB72 (See protein sequence)

Recommended Name: Pumilio homolog 2

Size: 1066 amino acids; 114216 Da

Subunit: Homodimer; homodimerizes in vitro. Interacts with DAZ, DAZL and NANOS1 via its pumilio repeats. Binds to a RNA

consensus sequence, that is related to the Nanos Response Element (NRE), a 16 bp sequence found in the 3'-UTR of the

Drosophila hb mRNA. Also binds to the NRE. Interacts with NANOS3 (By similarity). Interacts with SNAPIN

Subcellular location: Cytoplasm (Probable). Cytoplasmic granule (By similarity). Cytoplasm, perinuclear region.

Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins

and RNAs that appear when the cell is under stress. Co-localizes with NANOS3 in the stress granules (By similarity).

Co-localizes with NANOS1 and SNAPIN in the perinuclear region of germ cells

3 PDB 3D structures from and Proteopedia for PUM2:

3Q0Q (3D)

3Q0R (3D)

3Q0S (3D)

Secondary accessions: B3KSL0 D6W527 O00234 Q53TV7 Q8WY43 Q9HAN2

Alternative splicing: 3 isoforms: Q8TB72-1 Q8TB72-2 Q8TB72-3

Explore the universe of human proteins at neXtProt for PUM2: NX_Q8TB72

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TB72

PUM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_056132.1

ENSEMBL proteins:

ENSP00000338173 ENSP00000409905 ENSP00000385992 ENSP00000387399 ENSP00000396727

ENSP00000408384 ENSP00000413515 ENSP00000395098 ENSP00000354370 ENSP00000326746

ENSP00000440093

Human Recombinant Protein Products:

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	Novus Biologicals PUM2 Proteins Novus Biologicals PUM2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PUM2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0010494	cytoplasmic stress granule	ISS	--
GO:0048471	perinuclear region of cytoplasm	IDA	19168546

PUM2 for ontologies About GeneDecksing

PUM2 Antibody Products:

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Assay Products for PUM2:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PUM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PUM2 for domains About GeneDecksing

3 InterPro domains/families:

IPR011989 ARM-like

IPR001313 Pumilio_RNA-bd_rpt

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q8TB72

ProtoNet protein and cluster: Q8TB72

UniProtKB/Swiss-Prot: PUM2_HUMAN, Q8TB72

Domain: The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that

approximates a half doughnut. The number as well as the specific sequence of the repeats determine the specificity for

target mRNAs (By similarity)

Similarity: Contains 1 PUM-HD domain

Similarity: Contains 8 pumilio repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PUM2_HUMAN, Q8TB72

Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of

mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and

self-renewal of stem cells by regulating the translation of key transcripts

Induction: Down-regulated in keratinocytes upon UVB irradiation

miRNA Products:		OriGene 3'-UTR Clone: PUM2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PUM2
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate PUM2 (see all 62):
		hsa-miR-579 hsa-miR-582-3p hsa-miR-3164 hsa-miR-2052 hsa-miR-19b-2* hsa-miR-429 hsa-miR-485-3p hsa-miR-624

		SwitchGear 3'UTR luciferase reporter plasmid: PUM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PUM2 (see all 7) OriGene shRNA RFP: PUM2 OriGene siRNA: PUM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PUM2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PUM2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PUM2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PUM2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PUM2 (NM_015317)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PUM2
		Search LifeMap BioReagents cell lines for PUM2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PUM2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	--

PUM2 for ontologies About GeneDecksing

Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pum2):

endocrine/exocrine gland

reproductive system

PUM2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translational Control

Translational Control

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for PUM2

Translational Control

PUM2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PUM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/568 Interacting proteins for PUM2 (Q8TB72^{1, 2, 3} ENSP00000338173⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 568)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AURKA	O14965²^,³, ENSP00000216911⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000216911
DAZ1	Q9NQZ3¹^,²^,³, ENSP00000384573⁴	EBI-311190,EBI-997955 MINT-61576 MINT-45963 MINT-61575 I2D: score=3 STRING: ENSP00000384573
DAZ4	Q86SG3³, ENSP00000371742⁴	I2D: score=2 STRING: ENSP00000371742
DAZL	Q92904³, ENSP00000382373⁴	I2D: score=1 STRING: ENSP00000382373
DAZ3	Q9NR90³, ENSP00000371802⁴	I2D: score=1 STRING: ENSP00000371802

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006417	regulation of translation	IEA	--
GO:0034063	stress granule assembly	IEA	--

PUM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PUM2
Search CenterWatch for drugs/clinical trials and news about PUM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PUM2 gene:

NM_015317.1

Unigene Cluster for PUM2:

Pumilio homolog 2 (Drosophila)

Hs.467824 [show with all ESTs]

Unigene Representative Sequence: AF315591

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000338086(uc002rds.1 uc002rdt.1 uc002rdu.1 uc010yjz.1)

ENST00000440577 ENST00000403432 ENST00000442400 ENST00000420234 ENST00000429419

ENST00000432105 ENST00000446940 ENST00000424110 ENST00000361078(uc002rdq.1)

ENST00000319801(uc002rdr.2 uc010yjy.1) ENST00000536417

miRNA Products:		OriGene 3'-UTR Clone: PUM2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PUM2
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate PUM2 (see all 62):
		hsa-miR-579 hsa-miR-582-3p hsa-miR-3164 hsa-miR-2052 hsa-miR-19b-2* hsa-miR-429 hsa-miR-485-3p hsa-miR-624

		SwitchGear 3'UTR luciferase reporter plasmid: PUM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PUM2 (see all 7) OriGene shRNA RFP: PUM2 OriGene siRNA: PUM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PUM2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PUM2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PUM2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PUM2 (NM_015317)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PUM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PUM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PUM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PUM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PUM2

Additional cDNA sequence:

AF272350.1 AF315591.1 AK093847.1 AK304198.1 BC024218.2 BC112046.1 BC112048.1 BC143550.1

BC143552.1 BX641165.1 D87078.3

22 DOTS entries:

DT.454374 DT.97777829 DT.95202438 DT.99938620 DT.87078922 DT.439165 DT.95202445 DT.100795116

DT.121031120 DT.40210334 DT.91698460 DT.95202442 DT.100795118 DT.121031128 DT.121031166 DT.121031194

DT.121031198 DT.75148452 DT.75158918 DT.92443916 DT.92443918 DT.97798173

24/302 AceView cDNA sequences (see all 302):

BG682050 BG779152 AI263041 AA379042 AI123653 BP367941 AV682869 AA918513

AU156671 AA461053 BE646256 BM704279 BX645799 BE218307 BM769755 AI129257

AA020786 AL708749 BM785354 AW768766 AA730268 BM829189 BU181600 AW029423

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PUM2 (see all 9) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17a	·	17b	^	18a	·	18b	^	19a	·
SP1:					-		-																								-																-
SP2:																																															-
SP3:			-		-		-
SP4:
SP5:																													-		-		-

ExUns:	19b	^	20a	·	20b	^	21	^	22	^	23	^	24	^	25a	·	25b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PUM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PUM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGCCAATG

About this image

PUM2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

FES22 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

FES29 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PUM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PUM2

SOURCE GeneReport for Unigene cluster: Hs.467824

UniProtKB/Swiss-Prot: PUM2_HUMAN, Q8TB72

Tissue specificity: Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and

ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver,

muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus,

medulla oblongata and putamen. Expressed in all fetal tissues tested

SABiosciences Expression via Pathway-Focused PCR Array including PUM2:

Cardiotoxicity in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PUM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PUM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PUM2 gene from 8/32 species (see all 32) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PUM2¹	pumilio homolog 2 (Drosophila)	87.45(n) 94.72(a)		421961 NM_001039292.1 NP_001034381.1
lizard (Anolis carolinensis)	Reptilia	PUM2⁶	--	92(a)	1 ↔ 1	1(155119205-155172926)
zebrafish (Danio rerio)	Actinopterygii	pum2¹	pumilio homolog 2 (Drosophila)	70.89(n) 78.3(a)		567494 NM_001102570.1 NP_001096040.1
fruit fly (Drosophila melanogaster)	Insecta	pum^{1 , 3}	head involution protein binding³ pumilio¹	79(a)³ 50.63(n)¹ 49.08(a)¹		41094¹ NM_169260.3¹ NP_731316.2¹
worm (Caenorhabditis elegans)	Secernentea	puf-9³	pumilo repeats	59(a) (best of 2)		X(5876886-5880071) --
A. gossypii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_AAL152W¹	AAL152Wp	45.46(n) 39.14(a)		4618484 NM_207743.1 NP_982390.1
thale cress (Arabidopsis thaliana)	eudicotyledons	APUM6⁶ APUM1⁶ (see all 6)	pumilio 1 (see all 6)	25(a) 25(a) (see all 6)	many ↔ many many ↔ many (see all 6)	4(13154708-13159382) 2(12548931-12553433)
rice (Oryza sativa)	Liliopsida	AK070870.1²	--	77.66(n)		AK070870.1

ENSEMBL Gene Tree for PUM2 (if available)
TreeFam Gene Tree for PUM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PUM2 gene

PUM1²

1 SIMAP similar gene for PUM2 using alignment to 7 protein entries: PUM2_HUMAN (see all proteins):

PUM1

PUM2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for PUM2
PGOHUM00000236316

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79815021^1,2		--	20448188(+)	`CAAGGC/TGTGTA`	1	--	ds500¹		0	--	--	--	--
rs181780529^1,2		--	20448250(+)	`CAACAA/CTGCCT`	1	--	ds500¹		0	--	--	--	--
rs148785456^1,2		--	20448276(+)	`AAAACA/GGGCTA`	1	--	ds500¹		0	--	--	--	--
rs143949944^1,2		--	20448292(+)	`TTTATC/TCTATG`	1	--	ds500¹		0	--	--	--	--
rs146784543^1,2		--	20448370(+)	`GCTCCA/GGAACA`	1	--	ds500¹		0	--	--	--	--
rs114729959^1,2		--	20448379(+)	`CAGCAC/TCCATG`	1	--	ds500¹		1		WA	118
rs184138584^1,2		--	20448413(+)	`ACGTCA/GGAGTA`	1	--	ds500¹		0	--	--	--	--
rs6669^1,2	C,	--	20448521(-)	`AATGTG/ATGAAT`	1	--	ut3¹		3		MN NA	306
rs139552356^1,2		--	20448538(+)	`TTTCTA/GATTTA`	1	--	ut3¹		0	--	--	--	--
rs1043419^1,2	C,F,H,	--	20448561(-)	`TTCACT/CTCTTT`	1	--	ut3¹ ese³		19		MN NS EA NA	2420

HapMap Linkage Disequilibrium report for PUM2 (20448452 - 20551995 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PUM2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PUM2 for disorders           About GeneDecksing

OMIM gene information: 607205    OMIM disorders: --

9 diseases for PUM2:    About MalaCards

corpus callosum essential tremor tremor squamous cell carcinoma

azoospermia hermaphroditism carcinoma malaria

neuronitis

1 disease from the University of Copenhagen DISEASES database for PUM2:

Essential tremor

Human Genome Epidemiology (HuGE) Navigator: PUM2 (1 document)

Export disorders for PUM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PUM2 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with PUM2)

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Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)^{1, 2, 3} Moore F.L.... Reijo Pera R.A. (2003)
Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins. (PubMed id 12459267)^{1, 2, 3} Spassov D.S. and Jurecic R. (2002)
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{1, 2, 3} Nagase T....Nomura N. (1996)
The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells. (PubMed id 19168546)^{1, 2, 9} Ginter-Matuszewska B....Jaruzelska J. (2009)
Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PubMed id 12690449)^{1, 2, 9} Jaruzelska J....Reijo Pera R.A. (2003)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer. (PubMed id 12771951)^{1, 2} Dazard J.-E.... Givol D. (2003)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23369	HGNC: 14958	AceView: PUM2	Ensembl:ENSG00000055917	euGenes: HUgn23369
ECgene: PUM2	H-InvDB: PUM2

(According to HUGE)
About This Section

HUGE: KIAA0235

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PUM2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PUM2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PUM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PUM2 gene:
Search GeneIP for patents involving PUM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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pumilio homolog 2 (Drosophila)

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PUM2 Gene

pumilio homolog 2 (Drosophila)

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