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Aliases for PUM2 Gene

Aliases for PUM2 Gene

  • Pumilio RNA-Binding Family Member 2 2 3
  • Pumilio-2 3 4
  • KIAA0235 4 6
  • PUMH2 3 4
  • Pumilio Homolog 2 (Drosophila) 2
  • Pumilio (Drosphila) Homolog 2 2
  • Pumilio Homolog 2 3
  • PUML2 3

External Ids for PUM2 Gene

Summaries for PUM2 Gene

Entrez Gene Summary for PUM2 Gene

  • This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for PUM2 Gene

PUM2 (Pumilio RNA-Binding Family Member 2) is a Protein Coding gene. Among its related pathways are Translational Control. GO annotations related to this gene include RNA binding. An important paralog of this gene is PUM1.

UniProtKB/Swiss-Prot for PUM2 Gene

  • Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3-UTR of mRNA targets. Binds to an RNA consensus sequence, called Pumilio Response Element (PRE), 5-UGUANAUA-3, that is related to the Nanos Response Element (NRE). May regulate DCUN1D3 mRNA levels (PubMed:25349211). Capable of deadenylation-dependent and -independent modes of repression. May support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.

Gene Wiki entry for PUM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PUM2 Gene

Genomics for PUM2 Gene

Genomic Location for PUM2 Gene

Start:
20,248,691 bp from pter
End:
20,352,234 bp from pter
Size:
103,544 bases
Orientation:
Minus strand

Genomic View for PUM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PUM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PUM2 Gene

Regulatory Elements for PUM2 Gene

Proteins for PUM2 Gene

  • Protein details for PUM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB72-PUM2_HUMAN
    Recommended name:
    Pumilio homolog 2
    Protein Accession:
    Q8TB72
    Secondary Accessions:
    • B3KSL0
    • B4E2B6
    • D6W527
    • O00234
    • Q53TV7
    • Q8WY43
    • Q9HAN2

    Protein attributes for PUM2 Gene

    Size:
    1066 amino acids
    Molecular mass:
    114216 Da
    Quaternary structure:
    • Homodimer; homodimerizes in vitro. Interacts with DAZ, DAZL and NANOS1 via its pumilio repeats. Interacts with NANOS3 (By similarity). Interacts with SNAPIN. Recruits the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Interacts with DDX20.

    Three dimensional structures from OCA and Proteopedia for PUM2 Gene

    Alternative splice isoforms for PUM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PUM2 Gene

Proteomics data for PUM2 Gene at MOPED

Post-translational modifications for PUM2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys672 and Lys964

No data available for DME Specific Peptides for PUM2 Gene

Domains for PUM2 Gene

Protein Domains for PUM2 Gene

UniProtKB/Swiss-Prot:

PUM2_HUMAN
Domain:
  • The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half doughnut. RNA-binding occurs on the concave side of the surface (PubMed:21397187).:
    • Q8TB72
  • Contains 1 PUM-HD domain.:
    • Q8TB72
Similarity:
  • Contains 8 pumilio repeats.:
    • Q8TB72
genes like me logo Genes that share domains with PUM2: view

No data available for Gene Families for PUM2 Gene

Function for PUM2 Gene

Molecular function for PUM2 Gene

UniProtKB/Swiss-Prot Function: Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3-UTR of mRNA targets. Binds to an RNA consensus sequence, called Pumilio Response Element (PRE), 5-UGUANAUA-3, that is related to the Nanos Response Element (NRE). May regulate DCUN1D3 mRNA levels (PubMed:25349211). Capable of deadenylation-dependent and -independent modes of repression. May support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
UniProtKB/Swiss-Prot Induction: Down-regulated in keratinocytes upon UVB irradiation.

Gene Ontology (GO) - Molecular Function for PUM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005488 binding --
GO:0005515 protein binding IPI 12511597
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PUM2: view

Phenotypes for PUM2 Gene

genes like me logo Genes that share phenotypes with PUM2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PUM2 Gene

Localization for PUM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PUM2 Gene

Cytoplasm. Cytoplasmic granule. Cytoplasm, perinuclear region. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PUM2 Gene COMPARTMENTS Subcellular localization image for PUM2 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for PUM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0010494 cytoplasmic stress granule ISS --
GO:0031965 nuclear membrane IDA --
GO:0048471 perinuclear region of cytoplasm IDA 19168546
genes like me logo Genes that share ontologies with PUM2: view

Pathways for PUM2 Gene

SuperPathways for PUM2 Gene

Superpath Contained pathways
1 Translational Control
genes like me logo Genes that share pathways with PUM2: view

Pathways by source for PUM2 Gene

1 Cell Signaling Technology pathway for PUM2 Gene

Gene Ontology (GO) - Biological Process for PUM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0034063 stress granule assembly IEA --
genes like me logo Genes that share ontologies with PUM2: view

Transcripts for PUM2 Gene

Unigene Clusters for PUM2 Gene

Pumilio homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PUM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a ·
SP1: - - - -
SP2: -
SP3: - - -
SP4:
SP5: - - -
SP6: -
SP7:
SP8: - - -
SP9:

ExUns: 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for PUM2 Gene

GeneLoc Exon Structure for
PUM2
ECgene alternative splicing isoforms for
PUM2

Expression for PUM2 Gene

mRNA expression in normal human tissues for PUM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PUM2 Gene

SOURCE GeneReport for Unigene cluster for PUM2 Gene Hs.467824

mRNA Expression by UniProt/SwissProt for PUM2 Gene

Q8TB72-PUM2_HUMAN
Tissue specificity: Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.
genes like me logo Genes that share expressions with PUM2: view

Orthologs for PUM2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PUM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PUM2 36
  • 99.69 (n)
  • 99.81 (a)
PUM2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PUM2 36
  • 96.48 (n)
  • 98.59 (a)
PUM2 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PUM2 36
  • 96.2 (n)
  • 98.59 (a)
PUM2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pum2 36
  • 94.31 (n)
  • 97.74 (a)
Pum2 16
Pum2 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PUM2 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 96 (a)
OneToMany
-- 37
  • 94 (a)
OneToMany
-- 37
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pum2 36
  • 93.93 (n)
  • 97.54 (a)
chicken
(Gallus gallus)
Aves PUM2 36
  • 86.57 (n)
  • 93.77 (a)
PUM2 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PUM2 37
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pum2 36
  • 76.94 (n)
  • 84.73 (a)
zebrafish
(Danio rerio)
Actinopterygii pum2 37
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pum 37
  • 30 (a)
OneToMany
pum 38
  • 79 (a)
worm
(Caenorhabditis elegans)
Secernentea fbf-1 37
  • 21 (a)
ManyToMany
fbf-2 37
  • 21 (a)
ManyToMany
puf-11 37
  • 22 (a)
ManyToMany
puf-3 37
  • 25 (a)
ManyToMany
puf-5 37
  • 20 (a)
ManyToMany
puf-6 37
  • 20 (a)
ManyToMany
puf-7 37
  • 21 (a)
ManyToMany
puf-9 38
  • 59 (a)
puf-8 38
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUF3 37
  • 29 (a)
OneToMany
PUF3 39
soybean
(Glycine max)
eudicotyledons Gma.2466 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9347 37
  • 68 (a)
OneToMany
Species with no ortholog for PUM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PUM2 Gene

ENSEMBL:
Gene Tree for PUM2 (if available)
TreeFam:
Gene Tree for PUM2 (if available)

Paralogs for PUM2 Gene

Paralogs for PUM2 Gene

Selected SIMAP similar genes for PUM2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PUM2 Gene

genes like me logo Genes that share paralogs with PUM2: view

Variants for PUM2 Gene

Sequence variations from dbSNP and Humsavar for PUM2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2820 -- 20,349,673(+) ACATA(C/G)AGTAC intron-variant
rs6669 -- 20,248,760(-) AATGT(A/G)TGAAT utr-variant-3-prime
rs719148 -- 20,321,886(+) CTCCA(A/G)TGTTT intron-variant
rs741188 -- 20,252,246(+) AGACC(A/G)CATCT intron-variant
rs741189 -- 20,253,015(-) atagt(A/G)tttgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PUM2 Gene

Variant ID Type Subtype PubMed ID
esv29979 CNV Loss 17803354
nsv524207 CNV Gain 19592680

Relevant External Links for PUM2 Gene

HapMap Linkage Disequilibrium report
PUM2

Disorders for PUM2 Gene

(1) University of Copenhagen DISEASES for PUM2 Gene

Relevant External Links for PUM2

Genetic Association Database (GAD)
PUM2
Human Genome Epidemiology (HuGE) Navigator
PUM2
genes like me logo Genes that share disorders with PUM2: view

No data available for UniProtKB/Swiss-Prot for PUM2 Gene

Publications for PUM2 Gene

  1. The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells. (PMID: 19168546) Ginter-Matuszewska B. … Jaruzelska J. (Mol. Hum. Reprod. 2009) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  3. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PMID: 12690449) Jaruzelska J. … Reijo Pera R.A. (Dev. Genes Evol. 2003) 3 4 23
  4. Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins. (PMID: 12459267) Spassov D.S. … Jurecic R. (Gene 2002) 2 3 4
  5. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PMID: 12511597) Moore F.L. … Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4

Products for PUM2 Gene

  • Addgene plasmids for PUM2

Sources for PUM2 Gene

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