PUF60 Gene
protein-coding GIFtS: 55
GCID: GC08M144898
|
|
poly-U binding splicing factor 60KDa
| |
Aliases
for PUF60 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Poly-U Binding Splicing Factor 60KDa1 2 | | Siah Binding Protein 12 | | FIR1 2 3 | | 60 KDa Poly(U)-Binding-Splicing Factor3 | | SIAHBP11 2 3 | | ROBPI3 | | RoBPI1 2 | | RoBP13 | | FUSE-Binding Protein-Interacting Repressor2 3 | | Siah-BP13 | | FBP Interacting Repressor2 | | FBP-Interacting Repressor3 | | Poly(U)-Binding-Splicing Factor PUF602 | | Ro-Binding Protein 13 | | Pyrimidine Tract Binding Splicing Factor2 | | Siah-Binding Protein 13 | | Ro Ribonucleoprotein-Binding Protein 12 | | |
Export aliases for PUF60 gene to outside databasesPrevious GC identifers: GC08M144971 GC08M140151 |
Summaries
for PUF60 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PUF60:
This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, includingpre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNAelement (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYCtranscription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encodingmultiple isoforms have been observed for this gene. (provided by RefSeq, Aug 2012)
UniProtKB/Swiss-Prot: PUF60_HUMAN, Q9UHX1Function: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis andtranscription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through thecore-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcriptionfactor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicaseactivity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells.Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract ina cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed torepress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumorprogression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells.Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to thepyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA inassociation with TROVE2. Binds to poly(U) RNA
Gene Wiki entry for PUF60
|
Genomic Views
for PUF60 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PUF60 gene promoter:
AhR FOXF2 ARP-1 STAT5A Arnt c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PUF60
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PUF60 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3PUF60 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M144898: view genomic region
(about GC identifiers)
Start:
|
144,898,514 bp from pter |
End:
|
144,912,029 bp from pter |
Size:
|
13,516 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr8-,PATCHES 144,884,912-144,897,902 |
|
Proteins
for PUF60 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PUF60_HUMAN, Q9UHX1 (See
protein sequence)Recommended Name: Poly(U)-binding-splicing factor PUF60 Size: 559 amino acids; 59875 Da
Subunit: Homodimer. Associates with the spliceosome. Found in a complex with TROVE2 and Y5 RNA. Found in a complex withFUBP1 and far upstream element (FUSE) DNA segment. Interacts directly with ERCC3. Interacts with CDK7, GTF2H1 andSFRS11. Does not interact with ERCC3 in xeroderma pigmentosum complementation group B (XPB) cells
Subcellular location: Nucleus. Note=Colocalizes partially with TROVE2
Miscellaneous: Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB)cells
6/8 PDB 3D structures from  and Proteopedia  for PUF60 (see all 8):2DNY (3D)
2KXF (3D)
2KXH (3D)
2QFJ (3D)
3DXB (3D)
3UE2 (3D)
Secondary accessions: A8K8K8 Q969E7 Q96D94 Q96H63 Q99628 Q9NZA0 Q9UJY7Alternative splicing: 6 isoforms: Q9UHX1-1 Q9UHX1-2 Q9UHX1-3 Q9UHX1-4 Q9UHX1-5 Q9UHX1-6 Explore the universe of human proteins at neXtProt for PUF60: NX_Q9UHX1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UHX1
PUF60 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (8 alternative transcripts):
NP_001129505.1 NP_001258025.1 NP_001258026.1 NP_001258027.1 NP_001258028.1 NP_001258029.1 NP_055096.2 NP_510965.1
ENSEMBL proteins: ENSP00000434359 ENSP00000402953 ENSP00000322016 ENSP00000395417 ENSP00000322036 ENSP00000431960 ENSP00000432091 ENSP00000432610 ENSP00000436131 ENSP00000434863 ENSP00000437309 ENSP00000433403
Human Recombinant Protein Products for PUF60:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- | | GO:0005730 | NOT nucleolus |
IDA | -- | | GO:0019907 | colocalizes with cyclin-dependent protein kinase activating kinase holoenzyme complex |
IDA | 11445587 | | GO:0030529 | ribonucleoprotein complex |
IEA | -- |
PUF60 for ontologies About GeneDecksing
PUF60 Antibody Products:
Assay Products for PUF60: |
Protein
Domains /
Families
for PUF60 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PUF60 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UHX1ProtoNet protein and cluster: Q9UHX1 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: PUF60_HUMAN, Q9UHX1Domain: The third RNA recognition motif, called PUMP domain, is atypical and may rather mediate homodimerization and/orprotein-protein interactionsSimilarity: Belongs to the RRM half pint familySimilarity: Contains 3 RRM (RNA recognition motif) domains |
Function
for PUF60 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PUF60_HUMAN, Q9UHX1Function: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis andtranscription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through thecore-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcriptionfactor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicaseactivity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells.Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract ina cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed torepress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumorprogression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells.Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to thepyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA inassociation with TROVE2. Binds to poly(U) RNA Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
PUF60 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for PUF60:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PUF60 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PUF60 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): PUF60 (NM_078480) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PUF60 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUF60 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PUF60 |
|
Pathways & Interactions
for PUF60 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for PUF60):
PUF60 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PUF60
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/652 Interacting proteins for PUF60 (Q9UHX11, 2, 3 ENSP000003220164) via UniProtKB, MINT, STRING, and/or I2D (see all 652)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PCBP1 | Q153651, 2, 3, ENSP000003055564 | EBI-1053259,EBI-946095 MINT-2856343 MINT-2869868 I2D:
score=3 STRING: ENSP00000305556 | | PPP1R16A | Q96I341, 2, 3, ENSP000002925394 | EBI-1053259,EBI-710402 MINT-65190 I2D:
score=5 STRING: ENSP00000292539 | | CHD3 | Q128732, 3 | MINT-7945693 MINT-65742 I2D:
score=5 | | VIM | P086702, 3 | MINT-7945693 MINT-65741 I2D:
score=5 | | YWHAG | P619812, 3, ENSP000003063304 | MINT-50845 I2D:
score=4 STRING: ENSP00000306330 |
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
PUF60 for ontologies About GeneDecksing
|
Drugs & Compounds
for PUF60 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PUF60
1 HMDB Compound for PUF60 About this table
Search CenterWatch for drugs/clinical trials and news about PUF60
|
Transcripts
for PUF60 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PUF60 gene (8 alternative transcripts): NM_001136033.2 NM_001271096.1 NM_001271097.1 NM_001271098.1 NM_001271099.1 NM_001271100.1 NM_014281.4 NM_078480.2 Unigene Cluster for PUF60: Poly-U binding splicing factor 60KDa Hs.521924 [show with all ESTs]Unigene Representative Sequence: NM_00113603318/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000526683(uc003yzs.3 uc003yzt.3) ENST00000453551(uc003yzq.3)
ENST00000313352(uc003yzr.3) ENST00000456095 ENST00000349157 ENST00000527197
ENST00000524570(uc003yzu.1) ENST00000532884 ENST00000526459 ENST00000527744
ENST00000531951 ENST00000528320 ENST00000529999 ENST00000528999 ENST00000531897
ENST00000529693 ENST00000533162 ENST00000527584
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PUF60 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PUF60 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): PUF60 (NM_078480) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PUF60 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUF60 |
Additional cDNA sequence: AF114818.1 AF190744.1 AF217197.2 AK055941.1 AK292373.1 BC008875.2 BC009734.1 BC011265.1 BC011979.1 BC035435.2 CR457143.1 U51586.1 24/30 DOTS entries (see all 30): DT.95094753 DT.100059765 DT.92459964 DT.100741999 DT.449441 DT.97855693 DT.121479403 DT.100741974 DT.100043356 DT.92459920 DT.95098426 DT.92459913 DT.100741991 DT.100741988 DT.121479441 DT.121479470 DT.92459951 DT.102835154 DT.100059760 DT.100641958 DT.100678154 DT.102835155 DT.121479450 DT.121479481 24/805 AceView cDNA sequences (see all 805): BX420221 BE208548 BX421517 BG829209 BQ876744 BE311808 BX412848 BI197161 BM842248 BM759622 BU183824 BF981985 BU158510 BE387925 BM554543 CA391730 BU727165 BM462053 BQ421738 BQ688436 BQ638949 BC035435 AW245149 BM846002
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PUF60 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PUF60
|
Expression
for PUF60 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PUF60 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGACCCCA
About this image
See PUF60 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PUF60
SOURCE GeneReport for Unigene cluster: Hs.521924
UniProtKB/Swiss-Prot: PUF60_HUMAN, Q9UHX1Tissue specificity: Isoform 2 is expressed in colonic epithelium and colorectal epithelium cancer (at protein level).Isoform 6 is expressed in colorectal epithelial cancer but below detection level in colonic epithelium. Expressed inheart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, smallintestine, colon and peripheral blood leukocytes
SABiosciences Custom PCR Arrays for PUF60
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PUF60
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PUF60 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PUF60 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PUF60 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PUF60 |
Orthologs
for PUF60 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PUF60 gene from 6/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PUF601 |
poly-U binding splicing factor 60KDa |
83.58(n)
98.54(a) |
|
426402 NM_001031380.1 NP_001026551.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PUF606 |
-- |
95(a) |
1 ↔ 1 |
GL344533.1(11723-21413) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.68282 |
Xenopus laevis transcribed sequence with strong similarity more |
82.61(n) |
|
BX844428.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb33e112 |
Transcribed sequence with moderate similarity to protein more |
79.09(n) |
|
CA474237.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
pUf681 |
poly U binding factor 68kD |
65.22(n)
60.54(a) |
|
38173 NM_080384.3 NP_525123.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
rnp-61 |
Protein RNP-6 |
49.83(n)
49.28(a) |
|
171922 NM_058775.4 NP_491176.1 |
ENSEMBL Gene Tree for PUF60 (if available)
TreeFam Gene Tree for PUF60 (if available) |
Paralogs
for PUF60 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PUF60 gene
- PABPC1L2 PABPC52 PABPC42 PABPC4L2 ELAVL12 RBMS12 ELAVL42 ELAVL32
- RBMS32 PABPC32 ELAVL22 PABPC1L2B2 PABPC1L2A2 RBMS22 PABPC12
8 SIMAP similar genes for PUF60 using alignment to 7 protein entries: PUF60_HUMAN (see all proteins):HNRNPA1 PABPC4 RBMY1A1 PABPC1 PABPC1L2A PABPC1L2B
TIAL1 HNRNPD
PUF60 for paralogs About GeneDecksing
|
Genomic Variants
for PUF60 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PUF60 (144898514 - 144912029 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PUF60: -- | SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing PUF60: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PUF60 |
|
Disorders
/ Diseases
for PUF60 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PUF60 for disorders About GeneDecksing
OMIM gene information: 604819
OMIM disorders: --
7  diseases for PUF60: About MalaCardsxeroderma pigmentosum macular degeneration parkinson's disease colorectal cancer
ataxia prostatitis neuronitis
Export disorders for PUF60 gene to outside databases
|
Publications
for PUF60 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PUF60 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with PUF60) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins. (PubMed id 10668799)1, 2, 3, 9 Bouffard P.... Boire G. (2000)
- Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF. (PubMed id 17579712)1, 2, 3 Hastings M.L.... Krainer A.R. (2007)
- The FBP interacting repressor targets TFIIH to inhibit activated transcription. (PubMed id 10882074)1, 2, 3 Liu J....Levens D. (2000)
- An essential role of alternative splicing of c-myc suppressor FUSE- binding protein-interacting repressor in carcinogenesis. (PubMed id 16452196)1, 2 Matsushita K....Ochiai T. (2006)
- The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression. (PubMed id 16628215)1, 2 Liu J.... Levens D. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum. (PubMed id 11239393)1, 2 Liu J....Levens D. (2001)
- PUF60: a novel U2AF65-related splicing activity. (PubMed id 10606266)1, 2 Page-McCaw P.S.... Sharp P.A. (1999)
- c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy. (PubMed id 19273283)1, 9 Matsushita K....Nomura F. (2009)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
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External Searches for PUF60 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PUF60 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PUF60 gene
(According to HUGE)
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Specialized Databases showing PUF60 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for PUF60 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for PUF60 gene:
Search GeneIP for patents involving PUF60
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PUF60 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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