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Aliases for PTX3 Gene

Aliases for PTX3 Gene

  • Pentraxin 3 2 3 5
  • Pentraxin-Related Gene, Rapidly Induced By IL-1 Beta 2 3
  • Tumor Necrosis Factor-Inducible Gene 14 Protein 3 4
  • Tumor Necrosis Factor, Alpha-Induced Protein 5 2 3
  • Tumor Necrosis Factor Alpha-Induced Protein 5 3 4
  • Pentaxin-Related Protein PTX3 3 4
  • TNF Alpha-Induced Protein 5 3 4
  • Pentraxin 3, Long 2 3
  • Long Pentraxin 3 2 3
  • TNFAIP5 3 4
  • TSG-14 3 4
  • Pentaxin-Related Gene, Rapidly Induced By IL-1 Beta, Tumor Necrosis Factor, Alpha-Induced Protein 5 3
  • Pentaxin-Related Gene, Rapidly Induced By IL-1 Beta 2
  • Tumor Necrosis Factor-Inducible Protein TSG-14 3
  • Pentraxin-3 3
  • TSG14 4

External Ids for PTX3 Gene

Previous HGNC Symbols for PTX3 Gene


Previous GeneCards Identifiers for PTX3 Gene

  • GC03P154190
  • GC03P158101
  • GC03P158436
  • GC03P158475
  • GC03P158637
  • GC03P157154
  • GC03P154550

Summaries for PTX3 Gene

GeneCards Summary for PTX3 Gene

PTX3 (Pentraxin 3) is a Protein Coding gene. Diseases associated with PTX3 include Infectious Myocarditis and Hyper-Igd Syndrome. GO annotations related to this gene include virion binding and (1->3)-beta-D-glucan binding. An important paralog of this gene is NPTXR.

UniProtKB/Swiss-Prot for PTX3 Gene

  • Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.

Gene Wiki entry for PTX3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTX3 Gene

Genomics for PTX3 Gene

Regulatory Elements for PTX3 Gene

Enhancers for PTX3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTX3 on UCSC Golden Path with GeneCards custom track

Promoters for PTX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTX3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTX3 Gene

157,436,789 bp from pter
157,443,628 bp from pter
6,840 bases
Plus strand

Genomic View for PTX3 Gene

Genes around PTX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTX3 Gene

Proteins for PTX3 Gene

  • Protein details for PTX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pentraxin-related protein PTX3
    Protein Accession:
    Secondary Accessions:
    • B2R6T6
    • Q38M82

    Protein attributes for PTX3 Gene

    381 amino acids
    Molecular mass:
    41976 Da
    Quaternary structure:
    • Homooctamer; disulfide-linked. Binds to C1q (By similarity).

neXtProt entry for PTX3 Gene

Proteomics data for PTX3 Gene at MOPED

Post-translational modifications for PTX3 Gene

Other Protein References for PTX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PTX3 (Pentraxin 3/TSG-14)

No data available for DME Specific Peptides for PTX3 Gene

Domains & Families for PTX3 Gene

Gene Families for PTX3 Gene

Protein Domains for PTX3 Gene

Suggested Antigen Peptide Sequences for PTX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 pentaxin domain.
  • Contains 1 pentaxin domain.
genes like me logo Genes that share domains with PTX3: view

Function for PTX3 Gene

Molecular function for PTX3 Gene

GENATLAS Biochemistry:
pentaxin 3,acute phase reactant,induced by IL1B,in endothelial,hepatic,fibroblastic cells
UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
UniProtKB/Swiss-Prot Induction:
By IL1B/interleukin-1 beta and TNF.

Gene Ontology (GO) - Molecular Function for PTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001872 (1->3)-beta-D-glucan binding IEA --
genes like me logo Genes that share ontologies with PTX3: view
genes like me logo Genes that share phenotypes with PTX3: view

Animal Models for PTX3 Gene

MGI Knock Outs for PTX3:

Animal Model Products

miRNA for PTX3 Gene

miRTarBase miRNAs that target PTX3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTX3 Gene

Localization for PTX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTX3 Gene


Subcellular locations from

Jensen Localization Image for PTX3 Gene COMPARTMENTS Subcellular localization image for PTX3 gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PTX3 Gene

Pathways & Interactions for PTX3 Gene

SuperPathways for PTX3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IEA --
GO:0008228 opsonization IEA --
GO:0044871 negative regulation by host of viral glycoprotein metabolic process IDA 23544079
GO:0045429 positive regulation of nitric oxide biosynthetic process IEA --
GO:0046597 negative regulation of viral entry into host cell IDA 23544079
genes like me logo Genes that share ontologies with PTX3: view

No data available for Pathways by source and SIGNOR curated interactions for PTX3 Gene

Drugs & Compounds for PTX3 Gene

(19) Drugs for PTX3 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amlodipine Approved Pharma Calcium channel blocker 458
Heparin Approved, Investigational Pharma Antagonist 761,246
Valsartan Approved, Investigational Pharma Antagonist Angiotensin II AT1 receptor antagonist, High affinity, selective AT1 antagonist 275
Angiotensin II Pharma Full agonist, Agonist Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 1126
Angiotensin II Type 1 Receptor Blockers Pharma 1043

(4) Additional Compounds for PTX3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PTX3: view

Transcripts for PTX3 Gene

mRNA/cDNA for PTX3 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTX3 Gene

Pentraxin 3, long:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b

Relevant External Links for PTX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTX3 Gene

mRNA expression in normal human tissues for PTX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTX3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (18.8) and Amniocyte (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTX3 Gene

SOURCE GeneReport for Unigene cluster for PTX3 Gene Hs.591286

genes like me logo Genes that share expression patterns with PTX3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PTX3 Gene

Orthologs for PTX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PTX3 35
  • 87.37 (n)
  • 81.84 (a)
PTX3 36
  • 82 (a)
(Canis familiaris)
Mammalia PTX3 35
  • 80.91 (n)
  • 77.91 (a)
PTX3 36
  • 76 (a)
(Mus musculus)
Mammalia Ptx3 35
  • 84.6 (n)
  • 81.89 (a)
Ptx3 16
Ptx3 36
  • 82 (a)
(Pan troglodytes)
Mammalia PTX3 35
  • 99.13 (n)
  • 98.16 (a)
PTX3 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ptx3 35
  • 83.29 (n)
  • 81.36 (a)
(Monodelphis domestica)
Mammalia PTX3 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia PTX3 36
  • 56 (a)
(Gallus gallus)
Aves PTX3 35
  • 65.96 (n)
  • 58.2 (a)
PTX3 36
  • 51 (a)
(Anolis carolinensis)
Reptilia PTX3 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptx3 35
  • 59.06 (n)
  • 51.19 (a)
(Danio rerio)
Actinopterygii ptx3b 35
  • 51.25 (n)
  • 43.01 (a)
ptx3a 36
  • 33 (a)
ptx3b 36
  • 35 (a)
Species with no ortholog for PTX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTX3 Gene

Gene Tree for PTX3 (if available)
Gene Tree for PTX3 (if available)

Paralogs for PTX3 Gene

Paralogs for PTX3 Gene

genes like me logo Genes that share paralogs with PTX3: view

Variants for PTX3 Gene

Sequence variations from dbSNP and Humsavar for PTX3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_043140 -
VAR_043141 -
VAR_043142 -
VAR_043143 -

Structural Variations from Database of Genomic Variants (DGV) for PTX3 Gene

Variant ID Type Subtype PubMed ID
dgv1525e1 CNV Complex 17122850

Variation tolerance for PTX3 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PTX3 Gene

Disorders for PTX3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PTX3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
infectious myocarditis
hyper-igd syndrome
  • hyper igd syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PTX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTX3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PTX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTX3 Gene

Publications for PTX3 Gene

  1. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. (PMID: 1429570) Breviario F. … Introna M. (J. Biol. Chem. 1992) 2 3 4 23 67
  2. Pentraxin 3 and complement cascade activation in the failure of arteriovenous fistula. (PMID: 19772962) Castellano G. … Grandaliano G. (Atherosclerosis 2010) 3 23
  3. Pentraxin 3 in amniotic fluid: a novel association with intra-amniotic infection and inflammation. (PMID: 19792835) Cruciani L. … Di Renzo G.C. (J Perinat Med 2010) 3 23
  4. Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women. (PMID: 19846603) May L. … Westendorp R.G. (Biol. Reprod. 2010) 3 23
  5. Pentraxin 3 in amniotic fluid as a marker of intra-amniotic inflammation in women with preterm premature rupture of membranes. (PMID: 20022320) Kacerovsky M. … Andrys C. (Int J Gynaecol Obstet 2010) 3 23

Products for PTX3 Gene

Sources for PTX3 Gene