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Aliases for PTX3 Gene

Aliases for PTX3 Gene

  • Pentraxin 3 2 3 5
  • Tumor Necrosis Factor-Inducible Gene 14 Protein 3 4
  • Tumor Necrosis Factor Alpha-Induced Protein 5 3 4
  • TNF Alpha-Induced Protein 5 3 4
  • Long Pentraxin 3 2 3
  • TNFAIP5 3 4
  • TSG-14 3 4
  • Pentraxin-Related Gene, Rapidly Induced By IL-1 Beta 2
  • Pentaxin-Related Gene, Rapidly Induced By IL-1 Beta 2
  • Tumor Necrosis Factor, Alpha-Induced Protein 5 2
  • Tumor Necrosis Factor-Inducible Protein TSG-14 3
  • Pentraxin-Related Protein PTX3 3
  • Pentaxin-Related Protein PTX3 4
  • Pentraxin 3, Long 2
  • TSG14 4

External Ids for PTX3 Gene

Previous HGNC Symbols for PTX3 Gene

  • TNFAIP5

Previous GeneCards Identifiers for PTX3 Gene

  • GC03P154190
  • GC03P158101
  • GC03P158436
  • GC03P158475
  • GC03P158637
  • GC03P157154
  • GC03P154550

Summaries for PTX3 Gene

Entrez Gene Summary for PTX3 Gene

  • This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]

GeneCards Summary for PTX3 Gene

PTX3 (Pentraxin 3) is a Protein Coding gene. Diseases associated with PTX3 include Infectious Myocarditis and Hyper-Igd Syndrome. Among its related pathways are Immune System. GO annotations related to this gene include virion binding and (1->3)-beta-D-glucan binding. An important paralog of this gene is NPTX2.

UniProtKB/Swiss-Prot for PTX3 Gene

  • Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.

Gene Wiki entry for PTX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTX3 Gene

Genomics for PTX3 Gene

Regulatory Elements for PTX3 Gene

Enhancers for PTX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F157358 1.1 Ensembl ENCODE 11.4 -76.9 -76935 2.6 CTCF JUN MAX SIN3A BRCA1 RAD21 ZNF48 RFX5 RCOR1 NFE2 KRT18P34 PTX3 VEPH1 ENSG00000243176 LOC105374179
GH03F157201 0.7 Ensembl 10.8 -235.1 -235088 0.2 CTCF PKNOX1 ZNF654 STAT1 TRIM22 REST RAD21 STAT3 SMC3 ZNF143 ENSG00000243176 RNA5SP146 ENSG00000241770 KRT18P34 CCNL1 PTX3 VEPH1 LOC100420048
GH03F157429 0.8 FANTOM5 Ensembl 2.4 -6.9 -6927 0.5 ZNF664 POLR2H POLR2A CCNL1 PTX3 LOC105374179
GH03F157066 1.2 FANTOM5 Ensembl ENCODE 1.6 -369.7 -369678 1.8 CTCF MXI1 BHLHE40 JUND FOXP2 FOS ZBTB33 MAFK NFE2L2 TIPARP TIPARP-AS1 LINC00886 PQLC2L PTX3 LINC02029 RN7SKP177
GH03F157436 1 ENCODE 0.8 +1.2 1207 3.7 SIN3A YY1 ZNF121 GLIS2 FOS SP3 REST NFIL3 RFX3 GLIS1 KRT18P34 PTX3 VEPH1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTX3 on UCSC Golden Path with GeneCards custom track

Promoters for PTX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001377789 1311 3401 SIN3A YY1 ZNF121 GLIS2 FOS REST NFIL3 SMARCA4 RFX3 GLIS1

Genomic Location for PTX3 Gene

Chromosome:
3
Start:
157,436,789 bp from pter
End:
157,443,628 bp from pter
Size:
6,840 bases
Orientation:
Plus strand

Genomic View for PTX3 Gene

Genes around PTX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTX3 Gene

Proteins for PTX3 Gene

  • Protein details for PTX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26022-PTX3_HUMAN
    Recommended name:
    Pentraxin-related protein PTX3
    Protein Accession:
    P26022
    Secondary Accessions:
    • B2R6T6
    • Q38M82

    Protein attributes for PTX3 Gene

    Size:
    381 amino acids
    Molecular mass:
    41976 Da
    Quaternary structure:
    • Homooctamer; disulfide-linked. Binds to C1q (By similarity).

neXtProt entry for PTX3 Gene

Post-translational modifications for PTX3 Gene

Other Protein References for PTX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PTX3 (Pentraxin 3/TSG-14)
  • Santa Cruz Biotechnology (SCBT) Antibodies for PTX3

No data available for DME Specific Peptides for PTX3 Gene

Domains & Families for PTX3 Gene

Gene Families for PTX3 Gene

Protein Domains for PTX3 Gene

Suggested Antigen Peptide Sequences for PTX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P26022

UniProtKB/Swiss-Prot:

PTX3_HUMAN :
  • Contains 1 pentaxin domain.
Domain:
  • Contains 1 pentaxin domain.
genes like me logo Genes that share domains with PTX3: view

Function for PTX3 Gene

Molecular function for PTX3 Gene

GENATLAS Biochemistry:
pentaxin 3,acute phase reactant,induced by IL1B,in endothelial,hepatic,fibroblastic cells
UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
UniProtKB/Swiss-Prot Induction:
By IL1B/interleukin-1 beta and TNF.

Gene Ontology (GO) - Molecular Function for PTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001849 complement component C1q binding IDA 23544079
GO:0001872 (1->3)-beta-D-glucan binding IEA --
GO:0005515 protein binding IPI 19632990
GO:0042802 identical protein binding IPI 20363749
GO:0046790 virion binding IDA 23544079
genes like me logo Genes that share ontologies with PTX3: view
genes like me logo Genes that share phenotypes with PTX3: view

Animal Models for PTX3 Gene

MGI Knock Outs for PTX3:

Animal Model Products

miRNA for PTX3 Gene

miRTarBase miRNAs that target PTX3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTX3 Gene

Localization for PTX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTX3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTX3 gene
Compartment Confidence
extracellular 5
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 1429570
GO:0005615 extracellular space IDA 23544079
genes like me logo Genes that share ontologies with PTX3: view

Pathways & Interactions for PTX3 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with PTX3: view

Pathways by source for PTX3 Gene

2 Reactome pathways for PTX3 Gene

Gene Ontology (GO) - Biological Process for PTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IEA --
GO:0006954 inflammatory response TAS 1429570
GO:0008228 opsonization IEA --
GO:0044869 negative regulation by host of viral exo-alpha-sialidase activity IDA 23544079
GO:0044871 negative regulation by host of viral glycoprotein metabolic process IDA 23544079
genes like me logo Genes that share ontologies with PTX3: view

No data available for SIGNOR curated interactions for PTX3 Gene

Drugs & Compounds for PTX3 Gene

(21) Drugs for PTX3 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amlodipine Approved Pharma Calcium channel blocker 486
Heparin Approved, Investigational Pharma Antagonist 812,256
Valsartan Approved, Investigational Pharma Antagonist Angiotensin II AT1 receptor antagonist, High affinity, selective AT1 antagonist 291
Angiotensin II Pharma Full agonist, Agonist Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 1162
Angiotensin II Type 1 Receptor Blockers Pharma 1078

(3) Additional Compounds for PTX3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PTX3: view

Transcripts for PTX3 Gene

mRNA/cDNA for PTX3 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTX3 Gene

Pentraxin 3, long:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for PTX3 Gene

GeneLoc Exon Structure for
PTX3
ECgene alternative splicing isoforms for
PTX3

Expression for PTX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTX3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (18.8) and Amniocyte (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTX3 Gene



NURSA nuclear receptor signaling pathways regulating expression of PTX3 Gene:

PTX3

SOURCE GeneReport for Unigene cluster for PTX3 Gene:

Hs.591286
genes like me logo Genes that share expression patterns with PTX3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PTX3 Gene

Orthologs for PTX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTX3 34 35
  • 99.13 (n)
cow
(Bos Taurus)
Mammalia PTX3 34 35
  • 87.37 (n)
mouse
(Mus musculus)
Mammalia Ptx3 34 16 35
  • 84.6 (n)
rat
(Rattus norvegicus)
Mammalia Ptx3 34
  • 83.29 (n)
dog
(Canis familiaris)
Mammalia PTX3 34 35
  • 80.91 (n)
oppossum
(Monodelphis domestica)
Mammalia PTX3 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTX3 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTX3 34 35
  • 65.96 (n)
lizard
(Anolis carolinensis)
Reptilia PTX3 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptx3 34
  • 59.06 (n)
zebrafish
(Danio rerio)
Actinopterygii ptx3b 34 35
  • 51.25 (n)
ptx3a 35
  • 33 (a)
OneToMany
Species where no ortholog for PTX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTX3 Gene

ENSEMBL:
Gene Tree for PTX3 (if available)
TreeFam:
Gene Tree for PTX3 (if available)

Paralogs for PTX3 Gene

Paralogs for PTX3 Gene

genes like me logo Genes that share paralogs with PTX3: view

Variants for PTX3 Gene

Sequence variations from dbSNP and Humsavar for PTX3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs386352354 Uncertain significance 157,437,041(+) GACAA(C/T)GGACT intron-variant, reference, synonymous-codon
rs111242113 -- 157,434,917(+) TGAAC(A/G)ATGAA intron-variant, upstream-variant-2KB
rs111451363 -- 157,443,483(+) TGTCA(C/T)GTTTT intron-variant, utr-variant-3-prime
rs112277608 -- 157,437,858(+) GCAGA(C/T)GCGAG intron-variant, reference, missense
rs112325302 -- 157,441,671(+) TGGGC(A/G)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTX3 Gene

Variant ID Type Subtype PubMed ID
esv2759193 CNV gain 17122850

Variation tolerance for PTX3 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTX3 Gene

Disorders for PTX3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PTX3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
infectious myocarditis
hyper-igd syndrome
  • hyper igd syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PTX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTX3

Genetic Association Database (GAD)
PTX3
Human Genome Epidemiology (HuGE) Navigator
PTX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTX3
genes like me logo Genes that share disorders with PTX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTX3 Gene

Publications for PTX3 Gene

  1. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. (PMID: 1429570) Breviario F. … Introna M. (J. Biol. Chem. 1992) 2 3 4 22 64
  2. Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women. (PMID: 19846603) May L. … Westendorp R.G. (Biol. Reprod. 2010) 3 22 46 64
  3. Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity. (PMID: 12763682) Mantovani A. … Bottazzi B. (Vaccine 2003) 3 4 22 64
  4. Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins. (PMID: 7523502) Lee G.W. … Vilcek J. (J. Immunol. 1994) 3 4 22 64
  5. TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. (PMID: 7679696) Lee G.W. … Vilcek J. (J. Immunol. 1993) 3 4 22 64

Products for PTX3 Gene

Sources for PTX3 Gene

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