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PTX3 Gene

protein-coding   GIFtS: 60
GCID: GC03P157154

Pentraxin 3, Long

(Previous names: pentaxin-related gene, rapidly induced by IL-1 beta, tumor...)
(Previous symbol: TNFAIP5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pentraxin 3, Long1 2     TNF Alpha-Induced Protein 52 3
TNFAIP51 2 3     Pentaxin-Related Gene, Rapidly Induced By IL-1 Beta1
Pentraxin-Related Gene, Rapidly Induced By IL-1 Beta1 2     Pentaxin-Related Gene, Rapidly Induced By IL-1 Beta, Tumor Necrosis
Factor, Alpha-Induced Protein 52
Tumor Necrosis Factor, Alpha-Induced Protein 51 2     pentraxin-32
Pentaxin-Related Protein PTX32 3     Pentraxin-Related Protein PTX32
Tumor Necrosis Factor Alpha-Induced Protein 52 3     Tumor Necrosis Factor-Inducible Protein TSG-142
Tumor Necrosis Factor-Inducible Gene 14 Protein2 3     TSG143
TSG-142 3     

External Ids:    HGNC: 96921   Entrez Gene: 58062   Ensembl: ENSG000001636617   OMIM: 6024925   UniProtKB: P260223   

Export aliases for PTX3 gene to outside databases

Previous GC identifers: GC03P154190 GC03P158101 GC03P158436 GC03P158475 GC03P158637 GC03P154550


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PTX3 Gene:
PTX3 (pentraxin 3, long) is a protein-coding gene. Diseases associated with PTX3 include infectious myocarditis, and hyper-igd syndrome. GO annotations related to this gene include (1->3)-beta-D-glucan binding. An important paralog of this gene is NPTX2.

UniProtKB/Swiss-Prot: PTX3_HUMAN, P26022
Function: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly
clearance of self-components and female fertility (By similarity)

Gene Wiki entry for PTX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTX3 gene promoter:
         AML1a   MEF-2   Pax-2   Pax-2a   RelA   MEF-2A   PPAR-alpha   S8   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PTX3 promoter sequence
   Search Chromatin IP Primers for PTX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25   Ensembl cytogenetic band:  3q25.32   HGNC cytogenetic band: 3q25

PTX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTX3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P157154:  view genomic region     (about GC identifiers)

Start:
157,154,578 bp from pter      End:
157,161,417 bp from pter
Size:
6,840 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PTX3_HUMAN, P26022 (See protein sequence)
Recommended Name: Pentraxin-related protein PTX3 precursor  
Size: 381 amino acids; 41976 Da
Subunit: Homooctamer; disulfide-linked. Binds to C1q (By similarity)
Secondary accessions: B2R6T6 Q38M82

Explore the universe of human proteins at neXtProt for PTX3: NX_P26022

Explore proteomics data for PTX3 at MOPED

Post-translational modifications: 

  • Glycosylated (Probable)1
  • Glycosylation2 at Asn220
  • Modification sites at PhosphoSitePlus

  • See PTX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002843.2  
    ENSEMBL proteins: 
     ENSP00000295927  

    PTX3 Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for PTX3
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    OriGene Protein Over-expression Lysate for PTX3
    OriGene MassSpec for PTX3
    OriGene Custom Protein Services for PTX3
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    Novus Biologicals PTX3 Proteins
    Sino Biological Recombinant Protein for PTX3
    Sino Biological Cell Lysate for PTX3
    ProSpec Recombinant Protein for PTX3
    Cloud-Clone Corp. Proteins for PTX3

    PTX3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTX3
    R&D Systems Antibodies for PTX3 (Pentraxin 3/TSG-14)
    OriGene Antibodies for PTX3
    OriGene Custom Antibody Services for PTX3
    Novus Biologicals PTX3 Antibodies
    Abcam antibodies for PTX3
    Cloud-Clone Corp. Antibodies for PTX3
    Search ThermoFisher Antibodies for PTX3
    LSBio Antibodies in human, mouse, rat for PTX3

    PTX3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for PTX3 (Pentraxin 3/TSG-14)         (see all)
    GenScript Custom Assay Services for PTX3
    Enzo Life Sciences assays for PTX3
    Cloud-Clone Corp. ELISAs for PTX3
    Cloud-Clone Corp. CLIAs for PTX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013320 ConA-like_subgrp
     IPR001759 Pentaxin
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P26022

    ProtoNet protein and cluster: P26022

    1 Blocks protein domain: IPB001759 Pentaxin

    UniProtKB/Swiss-Prot: PTX3_HUMAN, P26022
    Similarity: Contains 1 pentaxin domain


    PTX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTX3_HUMAN, P26022
    Function: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly
    clearance of self-components and female fertility (By similarity)
    Induction: By IL1B/interleukin-1 beta and TNF

         Genatlas biochemistry entry for PTX3:
    pentaxin 3,acute phase reactant,induced by IL1B,in endothelial,hepatic,fibroblastic cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001872(1->3)-beta-D-glucan binding IEA--
         
    PTX3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PTX3:
     Increased S DNA content 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptx3):
     cellular  endocrine/exocrine gland  hematopoietic system  immune system  reproductive system 
     respiratory system 

    PTX3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptx3tm1Zuk for PTX3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTX3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PTX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTX3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTX3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTX3:
    hsa-mir-21-5p (MIRT005954)

    Block miRNA regulation of human, mouse, rat PTX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTX3 (see all 14):
    hsa-miR-224 hsa-miR-520d-5p hsa-miR-3660 hsa-miR-29c hsa-miR-29a hsa-miR-548s hsa-miR-410 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidPTX3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PTX3
    Predesigned siRNA for gene silencing in human, mouse, rat PTX3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTX3

    Clone
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    OriGene clones in human, mouse for PTX3 (see all 7)
    OriGene ORF clones in mouse, rat for PTX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTX3 (NM_002852)
    Sino Biological Human cDNA Clone for PTX3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTX3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PTX3
    Browse ESI BIO Cell Lines and PureStem Progenitors for PTX3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTX3_HUMAN, P26022: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    PTX3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTX3: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Antifungal Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for PTX3 (P260223 ENSP000002959274) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C1QBP027463, ENSP000003139674I2D: score=2 STRING: ENSP00000313967
    C1QAP027453, ENSP000003637734I2D: score=2 STRING: ENSP00000363773
    C1QCP027473, ENSP000003637684I2D: score=2 STRING: ENSP00000363768
    CFHP086033, ENSP000003563994I2D: score=2 STRING: ENSP00000356399
    FGF2P090383, ENSP000002644984I2D: score=2 STRING: ENSP00000264498
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001878response to yeast IEA--
    GO:0006954inflammatory response TAS1429570
    GO:0008228opsonization IEA--
    GO:0045429positive regulation of nitric oxide biosynthetic process IEA--
    GO:0050766positive regulation of phagocytosis IEA--

    PTX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTX3

    10 Novoseek inferred chemical compound relationships for PTX3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ccl3 36.3 2 20298930 (1), 19414540 (1), 20215499 (1)
    actinomycin d 25.2 4 9119472 (1), 16339571 (1), 7949102 (1)
    cycloheximide 23.8 3 9119472 (1), 16339571 (1), 7949102 (1)
    anti-fungal 8.87 4 16840729 (1), 17277044 (1), 19131771 (1)
    dexamethasone 8.33 4 7523502 (2), 16461742 (1), 7949102 (1)
    cholesterol 3.42 8 19238513 (2), 15262177 (1), 15324368 (1), 18571180 (1) (see all 5)
    nitric oxide 0 2 17533181 (2)
    tyrosine 0 1 17460897 (1)
    creatinine 0 2 17380301 (1), 15477419 (1)
    dopamine 0 1 15536184 (1)



    PTX3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PTX3 gene: 
    NM_002852.3  

    Unigene Cluster for PTX3:

    Pentraxin 3, long
    Hs.591286  [show with all ESTs]
    Unigene Representative Sequence: NM_002852
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000295927(uc003fbl.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PTX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTX3 (see all 14):
    hsa-miR-224 hsa-miR-520d-5p hsa-miR-3660 hsa-miR-29c hsa-miR-29a hsa-miR-548s hsa-miR-410 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidPTX3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PTX3
    Predesigned siRNA for gene silencing in human, mouse, rat PTX3
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTX3 (NM_002852)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTX3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PTX3
    OriGene qSTAR qPCR primer pairs in human, mouse for PTX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTX3
      QuantiTect SYBR Green Assays in human, mouse, rat PTX3
      QuantiFast Probe-based Assays in human, mouse, rat PTX3

    Additional mRNA sequence: 

    AK312705.1 BC027887.1 BC039733.1 M31166.1 X63053.1 X63613.1 

    3 DOTS entries:

    DT.311828  DT.100709433  DT.100777112 

    Selected AceView cDNA sequences (see all 126):

    BU680522 CA446598 BQ574679 BU681636 BU623796 BM970998 CR593354 CR612979 
    CD366496 CR605317 CR612981 CB528977 AI141490 BQ014604 AI952606 BQ001175 
    AA301817 CR606073 AA343499 CA448395 BQ015128 AW163320 AL569780 BM994330 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PTX3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for PTX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTTTCAG
    PTX3 Expression
    About this image


    PTX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             GABA neuron-like cells
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
             GABA neuron-like cells
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac Fibroblasts Myocardium
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
    PTX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591286
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTX3: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Antifungal Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PTX3
    OriGene qSTAR qPCR primer pairs in human, mouse for PTX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTX3
    QuantiTect SYBR Green Assays in human, mouse, rat PTX3
    QuantiFast Probe-based Assays in human, mouse, rat PTX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PTX3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptx31 , 5 pentraxin related gene1, 5 84.6(n)1
    81.89(a)1
      3 (30.25 cM)5
    192881  NM_008987.31  NP_033013.31 
     662199105 
    chicken
    (Gallus gallus)
    Aves PTX31 pentraxin 3, long 65.96(n)
    58.2(a)
      548626  NM_001017413.1  NP_001017413.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTX36
    pentraxin 3, long
    48(a)
    1 ↔ 1
    3(14843506-14852392)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ptx31 pentraxin 3, long 59.06(n)
    51.19(a)
      100494643  XM_002933243.2  XP_002933289.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ptx3b1 pentraxin 3, long b 51.25(n)
    43.01(a)
      566001  XM_689266.3  XP_694358.3 


    ENSEMBL Gene Tree for PTX3 (if available)
    TreeFam Gene Tree for PTX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTX3 gene
    NPTX22  APCS2  CRP2  PTX42  NPTX12  NPTXR2  

    PTX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    4 SNPs for PTX3    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44780391,2,4
    ----see VAR_0431432 mis40--------
    rs346553981,2,4
    ----see VAR_0431402 mis40--------
    rs38165271,2,4
    ----see VAR_0431412 mis40--------
    rs354157181,2,4
    ----see VAR_0431422 mis40--------

    HapMap Linkage Disequilibrium report for PTX3 (157154578 - 157161417 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PTX3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1525e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTX3
    DNA2.0 Custom Variant and Variant Library Synthesis for PTX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602492    OMIM disorders: --

    Selected diseases for PTX3 (see all 75):    
    About MalaCards
    infectious myocarditis    hyper-igd syndrome    iga glomerulonephritis    myxoid liposarcoma
    myocarditis    arteriovenous fistula    nonalcoholic steatohepatitis    bacteremia
    septic shock    preterm premature rupture of the membranes    acute myocardial infarction    angina pectoris
    chorioamnionitis    vasculitis    takayasu's arteritis    liposarcoma
    lymphadenitis    pulmonary tuberculosis    sepsis    idiopathic pulmonary fibrosis


    PTX3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PTX3 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 64 69 17828584 (2), 18045580 (2), 19164811 (2), 17380301 (2) (see all 44)
    response acute phase 62.5 6 16380821 (1), 15262177 (1), 15324368 (1), 16951703 (1) (see all 5)
    necrosis 44 27 1429570 (1), 7679696 (1), 9079634 (1), 15673302 (1) (see all 22)
    atherosclerosis 40.8 22 19238513 (5), 17380301 (2), 12006411 (2), 19729861 (1) (see all 11)
    preeclampsia 40.3 15 16647920 (5), 16816069 (3), 19544202 (2), 20374043 (1) (see all 7)
    atherosclerotic plaque 31.2 1 18220316 (1)
    bacterial infections 28.8 4 15977234 (1), 17277044 (1), 11404378 (1)
    shock septic 26.3 4 20119647 (1), 11445697 (1), 15226367 (1)
    autoimmunity 24.7 6 18614204 (3), 16380821 (1), 16166594 (1)
    acute myocardial infarction 22.3 7 10931803 (2), 17095712 (1), 12006411 (1), 12006390 (1) (see all 5)

    Genetic Association Database (GAD): PTX3
    Human Genome Epidemiology (HuGE) Navigator: PTX3 (18 documents)

    Export disorders for PTX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTX3 gene, integrated from 10 sources (see all 264):
    (articles sorted by number of sources associating them with PTX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. (PubMed id 1429570)1, 2, 3, 9 Breviario F.... Introna M. (J. Biol. Chem. 1992)
    2. TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. (PubMed id 7679696)1, 2, 9 Lee G.W.... Vilcek J. (J. Immunol. 1993)
    3. Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women. (PubMed id 19846603)1, 4, 9 May L....Westendorp R.G. (Biol. Reprod. 2010)
    4. Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins. (PubMed id 7523502)1, 2, 9 Lee G.W.... Vilcek J. (J. Immunol. 1994)
    5. Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity. (PubMed id 12763682)1, 2, 9 Mantovani A.... Bottazzi B. (Vaccine 2003)
    6. Nontuberculous mycobacterial cervicofacial lymphadenitis in children from the multicenter, randomized, controlled trial in The Netherlands: relevance of polymorphisms in candidate host immunity genes. (PubMed id 20399512)1, 4 Haverkamp M.H....van Dissel J.T. (Int. J. Pediatr. Otorhinolaryngol. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans. (PubMed id 17611589)1, 4 Olesen R....Sirugo G. (Genes Immun. 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. IL-1 inducible genes in human umbilical vein endothelial cells. (PubMed id 8131794)1, 2 Introna M....Mantovani A. (Eur. Heart J. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5806 HGNC: 9692 AceView: PTX3 Ensembl:ENSG00000163661 euGenes: HUgn5806
    ECgene: PTX3 H-InvDB: PTX3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTX3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTX3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTX3 gene:
    Search GeneIP for patents involving PTX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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