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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTX3 Gene

protein-coding   GIFtS: 60
GCID: GC03P157154

Pentraxin 3, Long

(Previous names: pentaxin-related gene, rapidly induced by IL-1 beta, tumor...)
(Previous symbol: TNFAIP5)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pentraxin 3, Long1 2     TNF Alpha-Induced Protein 52 3
TNFAIP51 2 3     Pentaxin-Related Gene, Rapidly Induced By IL-1 Beta1
Pentraxin-Related Gene, Rapidly Induced By IL-1 Beta1 2     Pentaxin-Related Gene, Rapidly Induced By IL-1 Beta, Tumor Necrosis
Factor, Alpha-Induced Protein 52
Tumor Necrosis Factor, Alpha-Induced Protein 51 2     pentraxin-32
Pentaxin-Related Protein PTX32 3     Pentraxin-Related Protein PTX32
Tumor Necrosis Factor Alpha-Induced Protein 52 3     Tumor Necrosis Factor-Inducible Protein TSG-142
Tumor Necrosis Factor-Inducible Gene 14 Protein2 3     TSG143
TSG-142 3     

External Ids:    HGNC: 96921   Entrez Gene: 58062   Ensembl: ENSG000001636617   OMIM: 6024925   UniProtKB: P260223   

Export aliases for PTX3 gene to outside databases

Previous GC identifers: GC03P154190 GC03P158101 GC03P158436 GC03P158475 GC03P158637 GC03P154550


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PTX3 Gene: 
PTX3 (pentraxin 3, long) is a protein-coding gene. Diseases associated with PTX3 include infectious myocarditis, and hyper-igd syndrome. GO annotations related to this gene include (1->3)-beta-D-glucan binding. An important paralog of this gene is NPTX2.

UniProtKB/Swiss-Prot: PTX3_HUMAN, P26022
Function: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly
clearance of self-components and female fertility (By similarity)

Gene Wiki entry for PTX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTX3 gene promoter:
         AML1a   MEF-2   Pax-2   Pax-2a   RelA   MEF-2A   PPAR-alpha   S8   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PTX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25   Ensembl cytogenetic band:  3q25.32   HGNC cytogenetic band: 3q25

PTX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTX3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P157154:  view genomic region     (about GC identifiers)

Start:
157,154,578 bp from pter      End:
157,161,417 bp from pter
Size:
6,840 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTX3_HUMAN, P26022 (See protein sequence)
Recommended Name: Pentraxin-related protein PTX3 precursor  
Size: 381 amino acids; 41976 Da
Subunit: Homooctamer; disulfide-linked. Binds to C1q (By similarity)
Subcellular location: Secreted
Secondary accessions: B2R6T6 Q38M82

Explore the universe of human proteins at neXtProt for PTX3: NX_P26022

Explore proteomics data for PTX3 at MOPED 

Post-translational modifications:

  • UniProtKB: Glycosylated (Probable)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26022

  • PTX3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTX3 Protein Expression
    REFSEQ proteins: NP_002843.2  
    ENSEMBL proteins: 
     ENSP00000295927  

    Human Recombinant Protein Products for PTX3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PTX3 (Pentraxin 3/TSG-14)
    Enzo Life Sciences proteins for PTX3
    OriGene Purified Protein for PTX3
    OriGene Protein Over-expression Lysate for PTX3
    OriGene MassSpec for PTX3 
    OriGene Custom Protein Services for PTX3
    GenScript Custom Purified and Recombinant Proteins Services for PTX3
    Novus Biologicals PTX3 Proteins
    Sino Biological Recombinant Protein for PTX3
    Sino Biological Cell Lysate for PTX3 
    ProSpec Recombinant Protein for PTX3
    Cloud-Clone Corp. Proteins for PTX3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    PTX3 for ontologies           About GeneDecksing



    PTX3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTX3
    R&D Systems Antibodies for PTX3 (Pentraxin 3/TSG-14)
    OriGene Antibodies for PTX3
    OriGene Custom Antibody Services for PTX3
    GenScript Custom Superior Antibodies Services for PTX3
    Novus Biologicals PTX3 Antibodies
    Abcam antibodies for PTX3
    Cloud-Clone Corp. Antibodies for PTX3 
    Search ThermoFisher Antibodies for PTX3
    LSBio Antibodies in human, mouse, rat for PTX3 

    Assay Products for PTX3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTX3
    R&D Systems ELISAs for PTX3 (Pentraxin 3/TSG-14)         (see all)
    GenScript Custom Assay Services for PTX3
    Enzo Life Sciences assays for PTX3
    Cloud-Clone Corp. ELISAs for PTX3 
    Cloud-Clone Corp. CLIAs for PTX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013320 ConA-like_subgrp
     IPR001759 Pentaxin
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P26022

    ProtoNet protein and cluster: P26022

    1 Blocks protein domain: IPB001759 Pentaxin

    UniProtKB/Swiss-Prot: PTX3_HUMAN, P26022
    Similarity: Contains 1 pentaxin domain


    PTX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTX3_HUMAN, P26022
    Function: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly
    clearance of self-components and female fertility (By similarity)
    Induction: By IL1B/interleukin-1 beta and TNF

         Genatlas biochemistry entry for PTX3:
    pentaxin 3,acute phase reactant,induced by IL1B,in endothelial,hepatic,fibroblastic cells

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001872(1->3)-beta-D-glucan binding IEA--
         
    PTX3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PTX3:
     Increased S DNA content 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptx3):
     cellular  endocrine/exocrine gland  immune system  reproductive system  respiratory system 

    PTX3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptx3tm1Zuk for PTX3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTX3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTX3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTX3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTX3:
    hsa-mir-21 (MIRT005954)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTX3
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate PTX3 (see all 14):
    hsa-miR-224 hsa-miR-520d-5p hsa-miR-3660 hsa-miR-29c hsa-miR-29a hsa-miR-548s hsa-miR-410 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidPTX3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTX3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTX3
    Sirion Biotech Customized adenovirus for overexpression of PTX3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PTX3 (see all 7)
    OriGene ORF clones in mouse, rat for PTX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTX3 (NM_002852)
    Sino Biological Human cDNA Clone for PTX3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTX3
    Sirion Biotech Customized lentivirus for stable overexpression of PTX3 
                         Customized lentivirus expression plasmids for stable overexpression of PTX3 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PTX3
    Search LifeMap BioReagents cell lines for PTX3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTX3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/11 Interacting proteins for PTX3 (P260223 ENSP000002959274) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C1QBP027463, ENSP000003139674I2D: score=2 STRING: ENSP00000313967
    C1QAP027453, ENSP000003637734I2D: score=2 STRING: ENSP00000363773
    C1QCP027473, ENSP000003637684I2D: score=2 STRING: ENSP00000363768
    CFHP086033, ENSP000003563994I2D: score=2 STRING: ENSP00000356399
    FGF2P090383, ENSP000002644984I2D: score=2 STRING: ENSP00000264498
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001878response to yeast IEA--
    GO:0006954inflammatory response TAS1429570
    GO:0008228opsonization IEA--
    GO:0045429positive regulation of nitric oxide biosynthetic process IEA--
    GO:0050766positive regulation of phagocytosis IEA--

    PTX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTX3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTX3

    10 Novoseek inferred chemical compound relationships for PTX3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ccl3 36.3 2 20298930 (1), 19414540 (1), 20215499 (1)
    actinomycin d 25.2 4 9119472 (1), 16339571 (1), 7949102 (1)
    cycloheximide 23.8 3 9119472 (1), 16339571 (1), 7949102 (1)
    anti-fungal 8.87 4 16840729 (1), 17277044 (1), 19131771 (1)
    dexamethasone 8.33 4 7523502 (2), 16461742 (1), 7949102 (1)
    cholesterol 3.42 8 19238513 (2), 15262177 (1), 15324368 (1), 18571180 (1) (see all 5)
    nitric oxide 0 2 17533181 (2)
    tyrosine 0 1 17460897 (1)
    creatinine 0 2 17380301 (1), 15477419 (1)
    dopamine 0 1 15536184 (1)

    Search CenterWatch for drugs/clinical trials and news about PTX3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTX3 gene: 
    NM_002852.3  

    Unigene Cluster for PTX3:

    Pentraxin 3, long
    Hs.591286  [show with all ESTs]
    Unigene Representative Sequence: NM_002852
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000295927(uc003fbl.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTX3
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate PTX3 (see all 14):
    hsa-miR-224 hsa-miR-520d-5p hsa-miR-3660 hsa-miR-29c hsa-miR-29a hsa-miR-548s hsa-miR-410 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidPTX3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTX3
    Clone
    Products:
         
    OriGene clones in human, mouse for PTX3 (see all 7)
    OriGene ORF clones in mouse, rat for PTX3
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    GenScript: all cDNA clones in your preferred vector: PTX3 (NM_002852)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTX3
    Sirion Biotech Customized lentivirus for stable overexpression of PTX3 
                         Customized lentivirus expression plasmids for stable overexpression of PTX3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PTX3
    OriGene qSTAR qPCR primer pairs in human, mouse for PTX3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTX3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTX3

    Additional mRNA sequence: 

    AK312705.1 BC027887.1 BC039733.1 M31166.1 X63053.1 X63613.1 

    3 DOTS entries:

    DT.311828  DT.100709433  DT.100777112 

    24/126 AceView cDNA sequences (see all 126):

    CB528977 AA343499 AI141490 BM970998 CD366496 AW163320 BU623796 BQ574679 
    CR606073 CA446598 BU680522 BQ001175 CR612981 BQ014604 BU681636 CR612979 
    BQ015128 CA448395 AI952606 CR593354 AA301817 CR605317 AI080546 BU624757 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PTX3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for PTX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTX3 expression in normal human tissues (normalized intensities)      PTX3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTTTCAG
    PTX3 Expression
    About this image


    PTX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             GABA neuron-like cells ( Generation of motor and gamma-aminobutyric acid (GABA)...
             Septum   
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Cardiac Fibroblasts Myocardium
             Coronary Artery Smooth Muscle Cells (CASMC)   
             Cardiac Myocytes   
     
     Fibroblast
             Detroit 551
             Human Prostate Fibroblasts (HPrF)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Wharton's jelly-derived stem cells
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Dermis (Integumentary System)    fully expand to see all 3 entries
             Dermal Fibroblasts Dorsal Dermis
             Human Hair Outer Root Sheath Cells (HHORSC)   

    See PTX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTX3

    SOURCE GeneReport for Unigene cluster: Hs.591286
        SABiosciences Expression via Pathway-Focused PCR Arrays including PTX3: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Antifungal Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for PTX3
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PTX3 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptx31 , 5 pentraxin related gene1, 5 84.6(n)1
    81.89(a)1
      3 (30.25 cM)5
    192881  NM_008987.31  NP_033013.31 
     662199105 
    chicken
    (Gallus gallus)
    Aves PTX31 pentraxin 3, long 66.14(n)
    58.2(a)
      548626  NM_001017413.1  NP_001017413.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTX36
    pentraxin 3, long
    48(a)
    1 ↔ 1
    3(14843506-14852392)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5660011 novel protein similar to vertebrate pentraxin-related more 51.34(n)
    43.58(a)
      566001  XM_689266.2  XP_694358.2 


    ENSEMBL Gene Tree for PTX3 (if available)
    TreeFam Gene Tree for PTX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTX3 gene
    NPTX22  APCS2  CRP2  PTX42  NPTX12  NPTXR2  

    PTX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    4 SNPs in PTX3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0431434
    ----see VAR_0431432 E K mis40--------
    VAR_0431404
    ----see VAR_0431402 H Q mis40--------
    VAR_0431414
    ----see VAR_0431412 A D mis40--------
    VAR_0431424
    ----see VAR_0431422 A V mis40--------

    HapMap Linkage Disequilibrium report for PTX3 (157154578 - 157161417 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PTX3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1525e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PTX3
    DNA2.0 Custom Variant and Variant Library Synthesis for PTX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602492    OMIM disorders: --

    20/60 diseases for PTX3 (see all 60):    About MalaCards
    infectious myocarditis    hyper-igd syndrome    iga glomerulonephritis    myxoid liposarcoma
    nonalcoholic steatohepatitis    myocarditis    preterm premature rupture of the membranes    acute myocardial infarction
    chorioamnionitis    vasculitis    liposarcoma    pulmonary tuberculosis
    polycythemia vera    polycythemia    vaginitis    myocardial infarction
    rheumatic disease    gout    proteinuria    glomerulonephritis


    PTX3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/19 Novoseek inferred disease relationships for PTX3 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 64 69 17828584 (2), 18045580 (2), 19164811 (2), 17380301 (2) (see all 44)
    response acute phase 62.5 6 16380821 (1), 15262177 (1), 15324368 (1), 16951703 (1) (see all 5)
    necrosis 44 27 1429570 (1), 7679696 (1), 9079634 (1), 15673302 (1) (see all 22)
    atherosclerosis 40.8 22 19238513 (5), 17380301 (2), 12006411 (2), 19729861 (1) (see all 11)
    preeclampsia 40.3 15 16647920 (5), 16816069 (3), 19544202 (2), 20374043 (1) (see all 7)
    atherosclerotic plaque 31.2 1 18220316 (1)
    bacterial infections 28.8 4 15977234 (1), 17277044 (1), 11404378 (1)
    shock septic 26.3 4 20119647 (1), 11445697 (1), 15226367 (1)
    autoimmunity 24.7 6 18614204 (3), 16380821 (1), 16166594 (1)
    acute myocardial infarction 22.3 7 10931803 (2), 17095712 (1), 12006411 (1), 12006390 (1) (see all 5)

    Genetic Association Database (GAD): PTX3
    Human Genome Epidemiology (HuGE) Navigator: PTX3 (18 documents)

    Export disorders for PTX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTX3 gene, integrated from 9 sources (see all 248):
    (articles sorted by number of sources associating them with PTX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. (PubMed id 1429570)1, 2, 3, 9 Breviario F.... Introna M. (1992)
    2. TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. (PubMed id 7679696)1, 2, 9 Lee G.W.... Vilcek J. (1993)
    3. Genetic variation in pentraxin (PTX) 3 gene associate s with PTX3 production and fertility in women. (PubMed id 19846603)1, 4, 9 May L....Westendorp R.G. (2010)
    4. Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins. (PubMed id 7523502)1, 2, 9 Lee G.W.... Vilcek J. (1994)
    5. Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity. (PubMed id 12763682)1, 2, 9 Mantovani A.... Bottazzi B. (2003)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Nontuberculous mycobacterial cervicofacial lymphadeni tis in children from the multicenter, randomized, controlled trial in The Nethe rlands: relevance of polymorphisms in candidate host immunity genes. (PubMed id 20399512)1, 4 Haverkamp M.H....van Dissel J.T. (2010)
    8. DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans. (PubMed id 17611589)1, 4 Olesen R....Sirugo G. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. IL-1 inducible genes in human umbilical vein endothelial cells. (PubMed id 8131794)1, 2 Introna M....Mantovani A. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5806 HGNC: 9692 AceView: PTX3 Ensembl:ENSG00000163661 euGenes: HUgn5806
    ECgene: PTX3 H-InvDB: PTX3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTX3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTX3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTX3 gene:
    Search GeneIP for patents involving PTX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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