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Aliases for PTX3 Gene

Aliases for PTX3 Gene

  • Pentraxin 3, Long 2 3
  • Pentraxin-Related Gene, Rapidly Induced By IL-1 Beta 2 3
  • Tumor Necrosis Factor-Inducible Gene 14 Protein 3 4
  • Tumor Necrosis Factor, Alpha-Induced Protein 5 2 3
  • Tumor Necrosis Factor Alpha-Induced Protein 5 3 4
  • Pentaxin-Related Protein PTX3 3 4
  • TNF Alpha-Induced Protein 5 3 4
  • TNFAIP5 3 4
  • TSG-14 3 4
  • Pentaxin-Related Gene, Rapidly Induced By IL-1 Beta, Tumor Necrosis Factor, Alpha-Induced Protein 5 3
  • Pentaxin-Related Gene, Rapidly Induced By IL-1 Beta 2
  • Tumor Necrosis Factor-Inducible Protein TSG-14 3
  • Pentraxin-Related Protein PTX3 3
  • Pentraxin-3 3
  • TSG14 4

External Ids for PTX3 Gene

Previous HGNC Symbols for PTX3 Gene

  • TNFAIP5

Previous GeneCards Identifiers for PTX3 Gene

  • GC03P154190
  • GC03P158101
  • GC03P158436
  • GC03P158475
  • GC03P158637
  • GC03P157154
  • GC03P154550

Summaries for PTX3 Gene

GeneCards Summary for PTX3 Gene

PTX3 (Pentraxin 3, Long) is a Protein Coding gene. Diseases associated with PTX3 include infectious myocarditis and hyper-igd syndrome. GO annotations related to this gene include (1->3)-beta-D-glucan binding. An important paralog of this gene is CRP.

UniProtKB/Swiss-Prot for PTX3 Gene

  • Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.

Gene Wiki entry for PTX3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTX3 Gene

Genomics for PTX3 Gene

Regulatory Elements for PTX3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTX3 Gene

Start:
157,436,789 bp from pter
End:
157,443,628 bp from pter
Size:
6,840 bases
Orientation:
Plus strand

Genomic View for PTX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTX3 Gene

Proteins for PTX3 Gene

  • Protein details for PTX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26022-PTX3_HUMAN
    Recommended name:
    Pentraxin-related protein PTX3
    Protein Accession:
    P26022
    Secondary Accessions:
    • B2R6T6
    • Q38M82

    Protein attributes for PTX3 Gene

    Size:
    381 amino acids
    Molecular mass:
    41976 Da
    Quaternary structure:
    • Homooctamer; disulfide-linked. Binds to C1q (By similarity).

neXtProt entry for PTX3 Gene

Proteomics data for PTX3 Gene at MOPED

Post-translational modifications for PTX3 Gene

Other Protein References for PTX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PTX3 (Pentraxin 3/TSG-14)

Protein Products

No data available for DME Specific Peptides for PTX3 Gene

Domains for PTX3 Gene

Protein Domains for PTX3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PTX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P26022

UniProtKB/Swiss-Prot:

PTX3_HUMAN :
  • P26022
Domain:
  • Contains 1 pentaxin domain.
genes like me logo Genes that share domains with PTX3: view

No data available for Gene Families for PTX3 Gene

Function for PTX3 Gene

Molecular function for PTX3 Gene

GENATLAS Biochemistry: pentaxin 3,acute phase reactant,induced by IL1B,in endothelial,hepatic,fibroblastic cells
UniProtKB/Swiss-Prot Function: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
UniProtKB/Swiss-Prot Induction: By IL1B/interleukin-1 beta and TNF

Gene Ontology (GO) - Molecular Function for PTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001849 complement component C1q binding IDA 23544079
GO:0001872 (1->3)-beta-D-glucan binding IEA --
GO:0046790 virion binding IDA 23544079
genes like me logo Genes that share ontologies with PTX3: view
genes like me logo Genes that share phenotypes with PTX3: view

Animal Models for PTX3 Gene

MGI Knock Outs for PTX3:

Animal Model Products

CRISPR Products

miRNA for PTX3 Gene

miRTarBase miRNAs that target PTX3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PTX3 Gene

Localization for PTX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTX3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTX3 Gene COMPARTMENTS Subcellular localization image for PTX3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 1429570
GO:0005615 extracellular space IDA 23544079
genes like me logo Genes that share ontologies with PTX3: view

Pathways for PTX3 Gene

SuperPathways for PTX3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antifungal Response in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Nitric Oxide Signaling Pathway in human,mouse,rat

Gene Ontology (GO) - Biological Process for PTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IEA --
GO:0006954 inflammatory response TAS 1429570
GO:0008228 opsonization IEA --
GO:0044869 negative regulation by host of viral exo-alpha-sialidase activity IDA 23544079
GO:0044871 negative regulation by host of viral glycoprotein metabolic process IDA 23544079
genes like me logo Genes that share ontologies with PTX3: view

No data available for Pathways by source for PTX3 Gene

Compounds for PTX3 Gene

(10) Novoseek inferred chemical compound relationships for PTX3 Gene

Compound -log(P) Hits PubMed IDs
ccl3 36.3 3
actinomycin d 25.2 3
cycloheximide 23.8 3
anti-fungal 8.87 3
dexamethasone 8.33 4
genes like me logo Genes that share compounds with PTX3: view

Transcripts for PTX3 Gene

mRNA/cDNA for PTX3 Gene

(126) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTX3 Gene

Pentraxin 3, long:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTX3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for PTX3 Gene

GeneLoc Exon Structure for
PTX3
ECgene alternative splicing isoforms for
PTX3

Expression for PTX3 Gene

mRNA expression in normal human tissues for PTX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTX3 Gene

SOURCE GeneReport for Unigene cluster for PTX3 Gene Hs.591286

genes like me logo Genes that share expressions with PTX3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTX3 Gene

Orthologs for PTX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTX3 35
  • 99.13 (n)
  • 98.16 (a)
PTX3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTX3 35
  • 87.37 (n)
  • 81.84 (a)
PTX3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTX3 35
  • 80.91 (n)
  • 77.91 (a)
PTX3 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptx3 35
  • 84.6 (n)
  • 81.89 (a)
Ptx3 16
Ptx3 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTX3 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTX3 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptx3 35
  • 83.29 (n)
  • 81.36 (a)
chicken
(Gallus gallus)
Aves PTX3 35
  • 65.96 (n)
  • 58.2 (a)
PTX3 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTX3 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptx3 35
  • 59.06 (n)
  • 51.19 (a)
zebrafish
(Danio rerio)
Actinopterygii ptx3a 36
  • 33 (a)
OneToMany
ptx3b 35
  • 51.25 (n)
  • 43.01 (a)
ptx3b 36
  • 35 (a)
OneToMany
Species with no ortholog for PTX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTX3 Gene

ENSEMBL:
Gene Tree for PTX3 (if available)
TreeFam:
Gene Tree for PTX3 (if available)

Paralogs for PTX3 Gene

Paralogs for PTX3 Gene

genes like me logo Genes that share paralogs with PTX3: view

Variants for PTX3 Gene

Sequence variations from dbSNP and Humsavar for PTX3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_043140 -
VAR_043141 -
VAR_043142 -
VAR_043143 -

Structural Variations from Database of Genomic Variants (DGV) for PTX3 Gene

Variant ID Type Subtype PubMed ID
dgv1525e1 CNV Complex 17122850

Relevant External Links for PTX3 Gene

HapMap Linkage Disequilibrium report
PTX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTX3 Gene

Disorders for PTX3 Gene

(19) Novoseek inferred disease relationships for PTX3 Gene

Disease -log(P) Hits PubMed IDs
inflammation 64 53
response acute phase 62.5 5
necrosis 44 22
atherosclerosis 40.8 17
preeclampsia 40.3 14

Relevant External Links for PTX3

Genetic Association Database (GAD)
PTX3
Human Genome Epidemiology (HuGE) Navigator
PTX3
genes like me logo Genes that share disorders with PTX3: view

No data available for UniProtKB/Swiss-Prot for PTX3 Gene

Publications for PTX3 Gene

  1. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. (PMID: 1429570) Breviario F. … Introna M. (J. Biol. Chem. 1992) 2 3 4 23
  2. Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins. (PMID: 7523502) Lee G.W. … Vilcek J. (J. Immunol. 1994) 3 4 23
  3. TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. (PMID: 7679696) Lee G.W. … Vilcek J. (J. Immunol. 1993) 3 4 23
  4. Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity. (PMID: 12763682) Mantovani A. … Bottazzi B. (Vaccine 2003) 3 4 23
  5. Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women. (PMID: 19846603) May L. … Westendorp R.G. (Biol. Reprod. 2010) 3 23 48

Products for PTX3 Gene

Sources for PTX3 Gene

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