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Aliases for PTTG2 Gene

Aliases for PTTG2 Gene

  • Pituitary Tumor-Transforming 2 2 3
  • Pituitary Tumor-Transforming Gene 2 Protein 4

External Ids for PTTG2 Gene

Previous GeneCards Identifiers for PTTG2 Gene

  • GC04P038126
  • GC04P037796
  • GC04P037859
  • GC04P037784
  • GC04P037639
  • GC04P037286

Summaries for PTTG2 Gene

GeneCards Summary for PTTG2 Gene

PTTG2 (Pituitary Tumor-Transforming 2) is a Protein Coding gene. Among its related pathways are Oocyte meiosis and Cell cycle. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is PTTG1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTTG2 Gene

Genomics for PTTG2 Gene

Regulatory Elements for PTTG2 Gene

Genomic Location for PTTG2 Gene

Chromosome:
4
Start:
37,960,435 bp from pter
End:
37,961,125 bp from pter
Size:
691 bases
Orientation:
Plus strand

Genomic View for PTTG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTTG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTTG2 Gene

Proteins for PTTG2 Gene

  • Protein details for PTTG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZH5-PTTG2_HUMAN
    Recommended name:
    Securin-2
    Protein Accession:
    Q9NZH5
    Secondary Accessions:
    • O95355
    • Q6NTC9
    • Q9UNJ6

    Protein attributes for PTTG2 Gene

    Size:
    202 amino acids
    Molecular mass:
    22302 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PTTG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTTG2 Gene

Proteomics data for PTTG2 Gene at MOPED

Post-translational modifications for PTTG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTTG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTTG2 Gene

Domains & Families for PTTG2 Gene

Protein Domains for PTTG2 Gene

Suggested Antigen Peptide Sequences for PTTG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZH5

UniProtKB/Swiss-Prot:

PTTG2_HUMAN :
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the securin family.
Domain:
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Family:
  • Belongs to the securin family.
genes like me logo Genes that share domains with PTTG2: view

No data available for Gene Families for PTTG2 Gene

Function for PTTG2 Gene

Molecular function for PTTG2 Gene

GENATLAS Biochemistry:
pituitary tumor transforming gene 2,intronless expressed in normal and pituitary gland and tumors

Gene Ontology (GO) - Molecular Function for PTTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0017124 SH3 domain binding IEA --
GO:0030414 peptidase inhibitor activity IBA --
genes like me logo Genes that share ontologies with PTTG2: view

Phenotypes for PTTG2 Gene

genes like me logo Genes that share phenotypes with PTTG2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTTG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PTTG2 Gene

Localization for PTTG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTTG2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTTG2 Gene COMPARTMENTS Subcellular localization image for PTTG2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for PTTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PTTG2: view

Pathways & Interactions for PTTG2 Gene

SuperPathways for PTTG2 Gene

genes like me logo Genes that share pathways with PTTG2: view

Pathways by source for PTTG2 Gene

1 BioSystems pathway for PTTG2 Gene
3 KEGG pathways for PTTG2 Gene

Interacting Proteins for PTTG2 Gene

Gene Ontology (GO) - Biological Process for PTTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0010466 negative regulation of peptidase activity IBA --
GO:0045143 homologous chromosome segregation IBA --
GO:0051276 chromosome organization IEA --
GO:2000816 negative regulation of mitotic sister chromatid separation IBA --
genes like me logo Genes that share ontologies with PTTG2: view

No data available for SIGNOR curated interactions for PTTG2 Gene

Drugs & Compounds for PTTG2 Gene

No Compound Related Data Available

Transcripts for PTTG2 Gene

mRNA/cDNA for PTTG2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTTG2 Gene

Pituitary tumor-transforming 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTTG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTTG2 Gene

No ASD Table

Relevant External Links for PTTG2 Gene

GeneLoc Exon Structure for
PTTG2
ECgene alternative splicing isoforms for
PTTG2

Expression for PTTG2 Gene

mRNA expression in normal human tissues for PTTG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTTG2 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTTG2 Gene



SOURCE GeneReport for Unigene cluster for PTTG2 Gene Hs.668806

mRNA Expression by UniProt/SwissProt for PTTG2 Gene

Q9NZH5-PTTG2_HUMAN
Tissue specificity: Expressed at low levels in the pituitary, liver, spleen, prostate, testis, ovary, small intestine and colon. Also expressed in various pituitary, testicular, liver and ovarian tumors.
genes like me logo Genes that share expression patterns with PTTG2: view

Protein tissue co-expression partners for PTTG2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PTTG2 Gene

Orthologs for PTTG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTTG2 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Pttg1 36
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 68 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PTTG1 36
  • 70 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia PTTG2 35
  • 98.6 (n)
  • 97.91 (a)
chicken
(Gallus gallus)
Aves PTTG1 36
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
OneToMany
Species with no ortholog for PTTG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTTG2 Gene

ENSEMBL:
Gene Tree for PTTG2 (if available)
TreeFam:
Gene Tree for PTTG2 (if available)

Paralogs for PTTG2 Gene

Paralogs for PTTG2 Gene

(3) SIMAP similar genes for PTTG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PTTG2: view

Variants for PTTG2 Gene

Sequence variations from dbSNP and Humsavar for PTTG2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_038956 -

Variation tolerance for PTTG2 Gene

Residual Variation Intolerance Score: 76.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTTG2 Gene

HapMap Linkage Disequilibrium report
PTTG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PTTG2 Gene

Disorders for PTTG2 Gene

Relevant External Links for PTTG2

Genetic Association Database (GAD)
PTTG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTTG2
genes like me logo Genes that share disorders with PTTG2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTTG2 Gene

Publications for PTTG2 Gene

  1. Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization. (PMID: 10806349) Chen L. … Kakar S.S. (Gene 2000) 2 67
  2. An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family. (PMID: 10084610) Prezant T.R. … Melmed S. (J. Clin. Endocrinol. Metab. 1999) 2 67
  3. PTTG2 silencing results in induction of epithelial-to-mesenchymal transition and apoptosis. (PMID: 23470537) MAcndez-Vidal C. … Pintor-Toro J.A. (Cell Death Dis 2013) 67
  4. Genome-wide association study of periodontal pathogen colonization. (PMID: 22699663) Divaris K. … Offenbacher S. (J. Dent. Res. 2012) 67
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67

Products for PTTG2 Gene

Sources for PTTG2 Gene

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