PTTG1IP Gene
protein-coding GIFtS: 51
GCID: GC21M046269
|
|
pituitary tumor-transforming 1 interacting protein
(Previous symbols: C21orf3, C21orf1)
| |
Aliases
for PTTG1IP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
|
| Aliases |
|---|
| Pituitary Tumor-Transforming 1 Interacting Protein1 2 | | Pituitary Tumor-Transforming Gene Protein-Binding Factor2 3 | | C21orf11 2 3 5 | | PTTG-Binding Factor2 3 | | C21orf31 2 3 5 | | Putative Surface Glycoprotein C21orf1 Precursor11 | | PBF1 2 3 5 | | Pituitary Tumor-Transforming Gene 1 Protein-Interacting Protein2 |
Export aliases for PTTG1IP gene to outside databasesPrevious GC identifers: GC21M042779 GC21M045126 GC21M045125 GC21M045093 GC21M031643 |
Summaries
for PTTG1IP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PTTG1IP:
The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates thenuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor byPTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclearlocalization, the nuclear localization of PTTG1, and its interaction with PTTG1. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801Function: May facilitate PTTG1 nuclear translocation
Gene Wiki entry for PTTG1IP
|
Genomic Views
for PTTG1IP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics, Whole Chromsome Sequence According to
Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
|
| GC21M046269: |
GeneLoc |
Nature:405,311-319 |
Start:
|
46,269,500 bp from pter |
31,778,924 bp from centromere |
End:
|
46,293,752 bp from pter |
31,803,008 bp from centromere |
Size:
|
24,253 bases |
24,085 bases |
Orientation:
|
minus strand |
minus strand |
| Whole chromosome sequencing: |
| cDNA sequence: |
Z50022 | | genomic clones: |
BAC-7B7 |
Proteins
for PTTG1IP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801 (See
protein sequence)Recommended Name: Pituitary tumor-transforming gene 1 protein-interacting protein precursor Size: 180 amino acids; 20324 Da
Subunit: Interacts with PTTG1
Subcellular location: Membrane; Single-pass type I membrane protein (Potential). Cytoplasm. Nucleus. Note=According toPubMed:10781616, it is found in the cytoplasm and the nucleus
Secondary accessions: B2RDP7 D3DSL9 Q9NS09Explore the universe of human proteins at neXtProt for PTTG1IP: NX_P53801
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P53801
PTTG1IP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004330.1
ENSEMBL proteins: ENSP00000380984 ENSP00000328325 ENSP00000380983 ENSP00000395374
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
PTTG1IP for ontologies About GeneDecksing
PTTG1IP Antibody Products:
Assay Products for PTTG1IP: |
Protein
Domains /
Families
for PTTG1IP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PTTG1IP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P53801ProtoNet protein and cluster: P53801 UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801Similarity: Contains 1 PSI domain |
Function
for PTTG1IP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801Function: May facilitate PTTG1 nuclear translocationInduction: By transcription factor RUNX2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTTG1IP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTTG1IP |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
PTTG1IP for ontologies About GeneDecksing
|
Pathways & Interactions
for PTTG1IP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
 SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTTG1IP
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for PTTG1IP (P538013 ENSP000003283254) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
PTTG1IP for ontologies About GeneDecksing
|
Drugs & Compounds
for PTTG1IP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PTTG1IP
Search CenterWatch for drugs/clinical trials and news about PTTG1IP / PTTG
|
Transcripts
for PTTG1IP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PTTG1IP gene: NM_004339.3 Unigene Cluster for PTTG1IP: Pituitary tumor-transforming 1 interacting protein Hs.474010 [show with all ESTs]Unigene Representative Sequence: AK0955867 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397887 ENST00000330938(uc002zgb.2 uc011afk.2) ENST00000397886
ENST00000474737 ENST00000494690 ENST00000480234 ENST00000445724
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTTG1IP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTTG1IP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PTTG1IP (NM_004339) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF149785.1 AK094882.1 AK095586.1 AK290139.1 AK293318.1 AK298557.1 AK299204.1 AK315626.1 BC000415.2 BC012858.1 BC019295.1 BC020983.1 BC031097.1 BC034250.1 L48984.1 Z50022.1 24/64 DOTS entries (see all 64): DT.92465796 DT.95371699 DT.95349475 DT.100884227 DT.92465818 DT.121133579 DT.100884232 DT.95371552 DT.100884215 DT.100884219 DT.100884217 DT.100884229 DT.100884225 DT.92465815 DT.40206424 DT.100884234 DT.121133564 DT.121133560 DT.121133603 DT.100884244 DT.121133504 DT.100884226 DT.121133565 DT.121133614 24/1424 AceView cDNA sequences (see all 1424): BF338331 AU136059 BE169386 AA055046 BE745788 AU134281 BG697405 BQ574911 BM856136 AI703272 AU107957 BQ928635 BG742414 AL600870 AU107964 BM750812 CA389031 BM313714 BE467249 AU280603 BM910589 BQ680265 AA352919 BE531085
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PTTG1IP (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for PTTG1IP
|
Expression
for PTTG1IP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PTTG1IP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAACTGAGA
About this image
See PTTG1IP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTTG1IP
SOURCE GeneReport for Unigene cluster: Hs.474010
UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for PTTG1IP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTTG1IP
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTTG1IP |
Orthologs
for PTTG1IP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PTTG1IP gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Pttg1ip1 , 5 |
pituitary tumor-transforming 1 interacting protein1, 5 |
79.56(n)1
76.79(a)1 |
|
10 (39.72 cM)5
1087051 NM_145925.21 NP_666037.11
775817205 |
chicken
(Gallus gallus) |
Aves |
LOC4248381 |
pituitary tumor-transforming gene 1 protein-interacting more |
70.2(n)
68.21(a) |
|
424838 XM_422649.3 XP_422649.3 |
lizard
(Anolis carolinensis) |
Reptilia |
PTTG1IP6 |
-- |
78(a) |
1 ↔ 1 |
3(33888337-33903285) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BU901815.12 |
-- |
74.23(n) |
|
BU901815.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
pttg1ipb6pttg1ipa6 |
pituitary tumor-transforming 1 interacting protein...pituitary tumor-transforming 1 interacting protein... |
47(a)34(a) |
many → 1many → 1 |
9(12931510-12935372) 6(10989640-11002396) |
worm
(Caenorhabditis elegans) |
Secernentea |
C37C3.126 |
-- |
21(a) |
1 ↔ 1 |
V(7838566-7839566) |
ENSEMBL Gene Tree for PTTG1IP (if available)
TreeFam Gene Tree for PTTG1IP (if available) |
Paralogs
for PTTG1IP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PTTG1IP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PTTG1IP (46269500 - 46293752 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PTTG1IP
1 CNV: 53434
1 Indel: 103110
Human Gene Mutation Database (HGMD): PTTG1IP
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTTG1IP |
|
Disorders
/ Diseases
for PTTG1IP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PTTG1IP for disorders About GeneDecksing
OMIM gene information: 603784
OMIM disorders: --
8  diseases for PTTG1IP: About MalaCardspituitary tumor intrahepatic cholangiocarcinoma pituitary adenoma cholangiocarcinoma
adenoma astrocytoma breast cancer thyroiditis
1 Novoseek disease relationship for PTTG1IP gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pituitary tumors |
69.7 |
3 |
20406982 (1), 15886233 (1) |
Export disorders for PTTG1IP gene to outside databases
|
Publications
for PTTG1IP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PTTG1IP gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with PTTG1IP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3. (PubMed id 9570958)1, 2, 3, 9 Yaspo M.-L....Lehrach H. (1998)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2, 3 Hattori M....Yaspo M.L. (2000)
- A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor- transforming gene product. (PubMed id 10781616)1, 2, 9 Chien W. and Pei L. (2000)
- Identification of novel genes of the bone-specific transcription factor Runx2. (PubMed id 15190888)1, 2 Stock M.... Otto F. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. (PubMed id 15178645)1, 9 Tfelt-Hansen J....Chattopadhyay N. (2004)
- A potential role for PTTG/securin in the developing human fetal brain. (PubMed id 12958169)1, 9 Boelaert K....McCabe C.J. (2003)
- Functional variable number of tandem repeats variation in the promoter of proto-oncogene PTTG1IP is associated with risk of estrogen r eceptor-positive breast cancer. (PubMed id 22404099)1 Xiang C....Wang H. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
|
External Searches for PTTG1IP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PTTG1IP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PTTG1IP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PTTG1IP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PTTG1IP gene:
Search GeneIP for patents involving PTTG1IP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PTTG1IP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTTG1IP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTTG1IP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTTG1IP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTTG1IP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTTG1IP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTTG1IP |
| |
 |  |  |  | |
| | | | Search Tocris compounds for PTTG1IP |
| |  |  |  |  | | | | |
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 | | | PTTG1IP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTTG1IP |
|  |  |  | | | | Search ThermoFisher Antibodies for PTTG1IP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTTG1IP |
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