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Aliases for PTTG1IP Gene

Aliases for PTTG1IP Gene

  • Pituitary Tumor-Transforming 1 Interacting Protein 2 3
  • C21orf1 3 4 6
  • C21orf3 3 4 6
  • PBF 3 4 6
  • Pituitary Tumor-Transforming Gene Protein-Binding Factor 3 4
  • PTTG-Binding Factor 3 4
  • Pituitary Tumor-Transforming Gene 1 Protein-Interacting Protein 3

External Ids for PTTG1IP Gene

Previous Symbols for PTTG1IP Gene

  • C21orf3
  • C21orf1

Summaries for PTTG1IP Gene

Entrez Gene Summary for PTTG1IP Gene

  • This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for PTTG1IP Gene

PTTG1IP (Pituitary Tumor-Transforming 1 Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PTTG1IP Gene

  • May facilitate PTTG1 nuclear translocation

Gene Wiki entry for PTTG1IP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTTG1IP Gene

Genomics for PTTG1IP Gene

Genomic Location for PTTG1IP Gene

Start:
44,849,585 bp from pter
End:
44,873,903 bp from pter
Size:
24,319 bases
Orientation:
Minus strand

Genomic View for PTTG1IP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTTG1IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTTG1IP Gene

Regulatory Elements for PTTG1IP Gene

Proteins for PTTG1IP Gene

  • Protein details for PTTG1IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53801-PTTG_HUMAN
    Recommended name:
    Pituitary tumor-transforming gene 1 protein-interacting protein
    Protein Accession:
    P53801
    Secondary Accessions:
    • B2RDP7
    • D3DSL9
    • Q9NS09

    Protein attributes for PTTG1IP Gene

    Size:
    180 amino acids
    Molecular mass:
    20324 Da
    Quaternary structure:
    • Interacts with PTTG1.

neXtProt entry for PTTG1IP Gene

Proteomics data for PTTG1IP Gene at MOPED

Post-translational modifications for PTTG1IP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys164 and Lys169
  • Glycosylation at Asn45 and Asn54

Other Protein References for PTTG1IP Gene

No data available for DME Specific Peptides for PTTG1IP Gene

Domains for PTTG1IP Gene

Protein Domains for PTTG1IP Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PTTG_HUMAN
Domain:
  • Contains 1 PSI domain.:
    • P53801
genes like me logo Genes that share domains with PTTG1IP: view

No data available for Gene Families for PTTG1IP Gene

Function for PTTG1IP Gene

Molecular function for PTTG1IP Gene

UniProtKB/Swiss-Prot Function: May facilitate PTTG1 nuclear translocation
UniProtKB/Swiss-Prot Induction: By transcription factor RUNX2.

Gene Ontology (GO) - Molecular Function for PTTG1IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004872 receptor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PTTG1IP: view

miRNA for PTTG1IP Gene

miRTarBase miRNAs that target PTTG1IP

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PTTG1IP Gene

Localization for PTTG1IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTTG1IP Gene

Membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTTG1IP Gene COMPARTMENTS Subcellular localization image for PTTG1IP gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PTTG1IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10781616
GO:0005737 cytoplasm IDA 10781616
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PTTG1IP: view

Pathways for PTTG1IP Gene

SuperPathways for PTTG1IP Gene

No Data Available

Gene Ontology (GO) - Biological Process for PTTG1IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IDA 10781616
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with PTTG1IP: view

No data available for Pathways by source for PTTG1IP Gene

Transcripts for PTTG1IP Gene

Unigene Clusters for PTTG1IP Gene

Pituitary tumor-transforming 1 interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTTG1IP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7:
SP8: - - - - - - - -
SP9: - - - - -
SP10: - - - - - - - - - -
SP11:

Relevant External Links for PTTG1IP Gene

GeneLoc Exon Structure for
PTTG1IP
ECgene alternative splicing isoforms for
PTTG1IP

Expression for PTTG1IP Gene

mRNA expression in normal human tissues for PTTG1IP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTTG1IP Gene

SOURCE GeneReport for Unigene cluster for PTTG1IP Gene Hs.474010

mRNA Expression by UniProt/SwissProt for PTTG1IP Gene

P53801-PTTG_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with PTTG1IP: view

Orthologs for PTTG1IP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTTG1IP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTTG1IP 36
  • 99.07 (n)
  • 98.89 (a)
PTTG1IP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTTG1IP 36
  • 76.38 (n)
  • 76 (a)
PTTG1IP 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 86 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
LOC100855485 36
  • 81.59 (n)
  • 86.71 (a)
mouse
(Mus musculus)
Mammalia Pttg1ip 36
  • 77.97 (n)
  • 74.71 (a)
Pttg1ip 16
Pttg1ip 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTTG1IP 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTTG1IP 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pttg1ip 36
  • 80.35 (n)
  • 81.46 (a)
chicken
(Gallus gallus)
Aves PTTG1IP 36
  • 59.77 (n)
  • 61.38 (a)
PTTG1IP 37
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTTG1IP 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pttg1ip.2 36
  • 57.93 (n)
  • 55.17 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101886260 36
  • 59.32 (n)
  • 63.78 (a)
pttg1ipa 37
  • 33 (a)
OneToMany
pttg1ipb 37
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToOne
Species with no ortholog for PTTG1IP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTTG1IP Gene

ENSEMBL:
Gene Tree for PTTG1IP (if available)
TreeFam:
Gene Tree for PTTG1IP (if available)

Paralogs for PTTG1IP Gene

No data available for Paralogs for PTTG1IP Gene

Variants for PTTG1IP Gene

Sequence variations from dbSNP and Humsavar for PTTG1IP Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs2787 -- 44,850,972(+) TTTAA(A/G)AAGGT utr-variant-3-prime, nc-transcript-variant
rs11312 -- 44,850,281(-) GTCCC(C/T)GTTCC utr-variant-3-prime, nc-transcript-variant
rs84191 -- 44,849,581(+) CACGC(A/G)GCATA downstream-variant-500B
rs84193 -- 44,850,461(-) TCTGA(C/G)CACTT utr-variant-3-prime, nc-transcript-variant
rs170960 -- 44,865,017(-) TTTCT(C/G)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTTG1IP Gene

Variant ID Type Subtype PubMed ID
dgv4775n71 CNV Loss 21882294
nsv913963 CNV Loss 21882294
nsv459298 CNV Loss 19166990
dgv4777n71 CNV Loss 21882294
nsv913967 CNV Loss 21882294
nsv913968 CNV Loss 21882294
dgv4778n71 CNV Loss 21882294
esv2577260 CNV Insertion 19546169
esv2723685 CNV Deletion 23290073
nsv470907 CNV Gain 18288195
dgv536n27 CNV Gain 19166990
esv2723686 CNV Deletion 23290073
dgv759e201 CNV Deletion 23290073
esv2723688 CNV Deletion 23290073

Relevant External Links for PTTG1IP Gene

HapMap Linkage Disequilibrium report
PTTG1IP
Human Gene Mutation Database (HGMD)
PTTG1IP

Disorders for PTTG1IP Gene

(1) Novoseek inferred disease relationships for PTTG1IP Gene

Disease -log(P) Hits PubMed IDs
pituitary tumors 69.7 2
genes like me logo Genes that share disorders with PTTG1IP: view

No data available for UniProtKB/Swiss-Prot for PTTG1IP Gene

Publications for PTTG1IP Gene

  1. Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3. (PMID: 9570958) Yaspo M.-L. … Lehrach H. (Genomics 1998) 2 3 4 23
  2. A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor- transforming gene product. (PMID: 10781616) Chien W. … Pei L. (J. Biol. Chem. 2000) 3 4 23
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 2 3 4
  4. A potential role for PTTG/securin in the developing human fetal brain. (PMID: 12958169) Boelaert K. … McCabe C.J. (FASEB J. 2003) 3 23
  5. Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. (PMID: 15178645) Tfelt-Hansen J. … Chattopadhyay N. (Endocrinology 2004) 3 23

Products for PTTG1IP Gene

  • antibodies-online proteins for PTTG1IP
  • antibodies-online antibodies for PTTG1IP
  • antibodies-online kits for PTTG1IP

Sources for PTTG1IP Gene

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