Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTTG1IP Gene

protein-coding   GIFtS: 53
GCID: GC21M046269

Pituitary Tumor-Transforming 1 Interacting Protein


(Previous symbols: C21orf3, C21orf1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Pituitary Tumor-Transforming 1 Interacting Protein1 2     Pituitary Tumor-Transforming Gene Protein-Binding Factor2 3
C21orf11 2 3 5     PTTG-Binding Factor2 3
C21orf31 2 3 5     Putative Surface Glycoprotein C21orf1 Precursor11
PBF2 3 5     Pituitary Tumor-Transforming Gene 1 Protein-Interacting Protein2

External Ids:    HGNC: 135241   Entrez Gene: 7542   Ensembl: ENSG000001832557   OMIM: 6037845   UniProtKB: P538013   

Export aliases for PTTG1IP gene to outside databases

Previous GC identifers: GC21M042779 GC21M045126 GC21M045125 GC21M045093 GC21M031643


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTTG1IP Gene:
The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the
nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor
by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear
localization, the nuclear localization of PTTG1, and its interaction with PTTG1. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTTG1IP Gene: 
PTTG1IP (pituitary tumor-transforming 1 interacting protein) is a protein-coding gene. Diseases associated with PTTG1IP include pituitary tumors, and pituitary adenoma. GO annotations related to this gene include molecular_function.

UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801
Function: May facilitate PTTG1 nuclear translocation

Gene Wiki entry for PTTG1IP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011515.12  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTTG1IP gene promoter:
         TBP   c-Fos   HFH-3   AP-1   Brachyury   LCR-F1   C/EBPalpha   FOXI1   Egr-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PTTG1IP promoter sequence

   Search SABiosciences Chromatin IP Primers for PTTG1IP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTTG1IP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
PTTG1IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTTG1IP gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M046269:   GeneLoc Nature:405,311-319
Start:
46,269,500 bp from pter       31,778,924 bp from centromere
End:
46,293,818 bp from pter 31,803,008 bp from centromere
Size:
24,319 bases 24,085 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: Z50022
genomic clones: BAC-7B7


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801 (See protein sequence)
Recommended Name: Pituitary tumor-transforming gene 1 protein-interacting protein precursor  
Size: 180 amino acids; 20324 Da
Subunit: Interacts with PTTG1
Subcellular location: Membrane; Single-pass type I membrane protein (Potential). Cytoplasm. Nucleus.
Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus
Secondary accessions: B2RDP7 D3DSL9 Q9NS09

Explore the universe of human proteins at neXtProt for PTTG1IP: NX_P53801

Explore proteomics data for PTTG1IP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53801

  • PTTG1IP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTTG1IP Protein Expression
    REFSEQ proteins: NP_004330.1  
    ENSEMBL proteins: 
     ENSP00000380984   ENSP00000328325   ENSP00000380983   ENSP00000395374  

    Human Recombinant Protein Products for PTTG1IP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PTTG1IP
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PTTG1IP
    GenScript Custom Purified and Recombinant Proteins Services for PTTG1IP
    Novus Biologicals PTTG1IP Proteins
    Novus Biologicals PTTG1IP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTTG1IP 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10781616
    GO:0005737cytoplasm IDA10781616
    GO:0016020membrane NAS--
    GO:0016021integral to membrane IEA--

    PTTG1IP for ontologies           About GeneDecksing



    PTTG1IP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PTTG1IP
    GenScript Custom Superior Antibodies Services for PTTG1IP
    Novus Biologicals PTTG1IP Antibodies
    Abcam antibodies for PTTG1IP
    Cloud-Clone Corp. Antibodies for PTTG1IP 
    Search ThermoFisher Antibodies for PTTG1IP
    LSBio Antibodies in human, mouse, rat for PTTG1IP 

    Assay Products for PTTG1IP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTTG1IP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTTG1IP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTTG1IP 
    Cloud-Clone Corp. CLIAs for PTTG1IP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003659 Plexin-like

    Graphical View of Domain Structure for InterPro Entry P53801

    ProtoNet protein and cluster: P53801

    UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801
    Similarity: Contains 1 PSI domain


    PTTG1IP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTTG_HUMAN, P53801
    Function: May facilitate PTTG1 nuclear translocation
    Induction: By transcription factor RUNX2

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    PTTG1IP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTTG1IP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTTG1IP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTTG1IP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTTG1IP 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTTG1IP:
    hsa-mir-124 (MIRT002596)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTTG1IP
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PTTG1IP (see all 9):
    hsa-miR-582-3p hsa-miR-3910 hsa-miR-647 hsa-miR-3163 hsa-miR-365 hsa-miR-105 hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidPTTG1IP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTTG1IP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTTG1IP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTTG1IP
    Sirion Biotech Customized adenovirus for overexpression of PTTG1IP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PTTG1IP (see all 7)
    OriGene ORF clones in mouse, rat for PTTG1IP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTTG1IP (NM_004339)
    Sino Biological Human cDNA Clone for PTTG1IP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTTG1IP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTTG1IP
    Sirion Biotech Customized lentivirus for stable overexpression of PTTG1IP 
                         Customized lentivirus expression plasmids for stable overexpression of PTTG1IP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PTTG1IP
    Search LifeMap BioReagents cell lines for PTTG1IP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTTG1IP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTTG1IP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for PTTG1IP (P538013 ENSP000003283254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTTG1O959973, ENSP000003449364I2D: score=3 STRING: ENSP00000344936
    UBCENSP000003448184STRING: ENSP00000344818
    RAB4AENSP000003556514STRING: ENSP00000355651
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus IDA10781616

    PTTG1IP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTTG1IP (PTTG)

    Search CenterWatch for drugs/clinical trials and news about PTTG1IP / PTTG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTTG1IP gene: 
    NM_004339.3  

    Unigene Cluster for PTTG1IP:

    Pituitary tumor-transforming 1 interacting protein
    Hs.474010  [show with all ESTs]
    Unigene Representative Sequence: AK095586
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397887 ENST00000330938(uc002zgb.2 uc011afk.2) ENST00000397886
    ENST00000474737 ENST00000494690 ENST00000480234 ENST00000445724
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTTG1IP
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PTTG1IP (see all 9):
    hsa-miR-582-3p hsa-miR-3910 hsa-miR-647 hsa-miR-3163 hsa-miR-365 hsa-miR-105 hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidPTTG1IP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTTG1IP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTTG1IP
    Clone
    Products:
         
    OriGene clones in human, mouse for PTTG1IP (see all 7)
    OriGene ORF clones in mouse, rat for PTTG1IP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTTG1IP (NM_004339)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTTG1IP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTTG1IP
    Sirion Biotech Customized lentivirus for stable overexpression of PTTG1IP 
                         Customized lentivirus expression plasmids for stable overexpression of PTTG1IP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PTTG1IP
    OriGene qSTAR qPCR primer pairs in human, mouse for PTTG1IP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTTG1IP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTTG1IP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTTG1IP

    Additional mRNA sequence: 

    AF149785.1 AK094882.1 AK095586.1 AK290139.1 AK293318.1 AK298557.1 AK299204.1 AK315626.1 
    BC000415.2 BC012858.1 BC019295.1 BC020983.1 BC031097.1 BC034250.1 L48984.1 Z50022.1 

    24/64 DOTS entries (see all 64):

    DT.92465796  DT.95371699  DT.95349475  DT.100884227  DT.92465818  DT.121133579  DT.100884232  DT.95371552 
    DT.100884215  DT.100884219  DT.100884217  DT.100884229  DT.100884225  DT.92465815  DT.100884234  DT.40206424 
    DT.121133564  DT.121133560  DT.121133603  DT.100884244  DT.121133504  DT.100738564  DT.100884226  DT.121133565 

    24/1424 AceView cDNA sequences (see all 1424):

    BU629910 BE326610 AU130850 AW196047 BU931131 CA406720 W79120 CD172089 
    AU131079 BM561515 BX414058 AW467466 BG178116 CR592911 AU107965 AU107949 
    AU107970 BQ217856 BM048210 AW103099 BU193758 BG818193 BQ015387 BP354310 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PTTG1IP (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                          -     -     -     -     -           -     -                           
    SP2:                          -     -     -     -     -           -     -           -               
    SP3:                          -     -     -     -     -           -     -                           
    SP4:                                                  -           -     -     -                     
    SP5:                                                  -           -     -                           


    ECgene alternative splicing isoforms for PTTG1IP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTTG1IP expression in normal human tissues (normalized intensities)      PTTG1IP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACTGAGA
    PTTG1IP Expression
    About this image


    PTTG1IP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             brain/hindbrain   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Blood (Cardiovascular System)
             mouse/organ system/cardiovascular system   

    See PTTG1IP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTTG1IP

    SOURCE GeneReport for Unigene cluster: Hs.474010

    UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for PTTG1IP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PTTG1IP
    OriGene qSTAR qPCR primer pairs in human, mouse for PTTG1IP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTTG1IP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTTG1IP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTTG1IP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTTG1IP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PTTG1IP gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pttg1ip1 , 5 pituitary tumor-transforming 1 interacting protein1, 5 79.56(n)1
    76.79(a)1
      10 (39.72 cM)5
    1087051  NM_145925.21  NP_666037.11 
     775817205 
    chicken
    (Gallus gallus)
    Aves LOC4248381 pituitary tumor-transforming gene 1 protein-interacting more 70.2(n)
    68.21(a)
      424838  XM_422649.3  XP_422649.3 
    lizard
    (Anolis carolinensis)
    Reptilia PTTG1IP6
    --
    --
    65(a)
    40(a)
    1 ↔ 1
    possible ortholog
    3(33884693-33908531)
    6(20424711-20447395)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU901815.12   -- 74.23(n)    BU901815.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01072585.16
    pttg1ipb6
    (see all 3)
    Uncharacterized protein
    pituitary tumor-transforming 1 interacting protein...
    (see all 3)
    55(a)
    47(a)
    (see all 3)
    possible ortholog
    many → 1
    (see all 3)
    16(57691461-57713739)
    9(12931510-12935372)
    worm
    (Caenorhabditis elegans)
    Secernentea C37C3.126
    Protein C37C3.12
    22(a)
    1 ↔ 1
    V(7838585-7839585)


    ENSEMBL Gene Tree for PTTG1IP (if available)
    TreeFam Gene Tree for PTTG1IP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/790 SNPs in PTTG1IP are shown (see all 790)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819730011,2
    --46269074(+) GGGCCA/GGGGTG 1 -- int10--------
    rs28387051,2
    C,F,O,H--46269114(+) AGACAC/GCCAGG 1 -- int114Minor allele frequency- G:0.25NA NS EA WA 921
    rs1421166441,2
    --46269150(+) GCGGGA/CGCCTC 1 -- int10--------
    rs754644391,2
    C,F--46269179(+) CACGGG/CGGGGC 1 -- int11Minor allele frequency- C:0.21WA 118
    rs1861487341,2
    --46269200(+) CTTCCC/TGAGGC 1 -- int10--------
    rs99777311,2
    C,F,A--46269214(+) CCTGCC/TTTCTC 1 -- int12Minor allele frequency- T:0.12WA NA 238
    rs1175992301,2
    C,F--46269224(+) CCCCCG/AGCCCT 1 -- int11Minor allele frequency- A:0.05EA 120
    rs1124468121,2
    C,F--46269242(+) CAGCGC/TGAGTG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1807145891,2
    --46269397(+) TCCCAC/TGATGG 1 -- int10--------
    rs2353111,2
    C,F,H--46269427(-) AGGCTT/GTTTTG 1 -- int110Minor allele frequency- G:0.11NS EA NA CSA 555

    HapMap Linkage Disequilibrium report for PTTG1IP (46269500 - 46293818 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for PTTG1IP (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv759e201CNV Deletion23290073
    esv2723686CNV Deletion23290073
    esv2723685CNV Deletion23290073
    esv2723688CNV Deletion23290073
    esv2577260CNV Insertion19546169
    dgv4778n71CNV Loss21882294
    nsv913963CNV Loss21882294
    nsv459298CNV Loss19166990
    nsv913967CNV Loss21882294
    dgv4775n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): PTTG1IP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PTTG1IP
    DNA2.0 Custom Variant and Variant Library Synthesis for PTTG1IP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603784    OMIM disorders: --

    8 diseases for PTTG1IP:    About MalaCards
    pituitary tumors    pituitary adenoma    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    astrocytoma    adenoma    thyroiditis    breast cancer


    PTTG1IP for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PTTG1IP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary tumors 69.7 3 20406982 (1), 15886233 (1)


    Export disorders for PTTG1IP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTTG1IP gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with PTTG1IP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3. (PubMed id 9570958)1, 2, 3, 9 Yaspo M.-L....Lehrach H. (1998)
    2. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2, 3 Hattori M....Yaspo M.L. (2000)
    3. A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor- transforming gene product. (PubMed id 10781616)1, 2, 9 Chien W. and Pei L. (2000)
    4. Identification of novel genes of the bone-specific transcription factor Runx2. (PubMed id 15190888)1, 2 Stock M.... Otto F. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. (PubMed id 15178645)1, 9 Tfelt-Hansen J....Chattopadhyay N. (2004)
    8. A potential role for PTTG/securin in the developing human fetal brain. (PubMed id 12958169)1, 9 Boelaert K....McCabe C.J. (2003)
    9. Prognostic significance of pituitary tumour-transformi ng gene-binding factor (PBF) expression in papillary thyroid carcinoma. (PubMed id 22888961)1 Hsueh C....Ueng S.H. (2013)
    10. Hepatitis B virus mRNA-mediated miR-122 inhibition upr egulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor gr owth and cell invasion. (PubMed id 23221562)1 Li C....Meng S. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 754 HGNC: 13524 AceView: PTTG1IP Ensembl:ENSG00000183255 euGenes: HUgn754
    ECgene: PTTG1IP H-InvDB: PTTG1IP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTTG1IP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTTG1IP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTTG1IP gene:
    Search GeneIP for patents involving PTTG1IP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PTTG1IP  
     OriGene qPCR primer pairs and template standards for PTTG1IP   OriGene Protein Over-expression Lysate for PTTG1IP  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PTTG1IP  
     OriGene qSTAR qPCR primer pairs in human, mouse for PTTG1IP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PTTG1IP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PTTG1IP   OriGene Custom Protein Services for PTTG1IP  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTTG1IP
     QIAGEN SeqTarget long-range PCR primers for resequencing PTTG1IP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTTG1IP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTTG1IP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTTG1IP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTTG1IP
     GenScript Custom Purified and Recombinant Proteins Services for PTTG1IP GenScript cDNA clones with any tag delivered in your preferred vector for PTTG1IP
     GenScript Custom Assay Services for PTTG1IP GenScript Custom Superior Antibodies Services for PTTG1IP
     GenScript Custom overexpressing Cell Line Services for PTTG1IP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PTTG1IP promoter
     Search Chromatin IP Primers for PTTG1IP
     RT2 qPCR Primer Assay in human, mouse, rat PTTG1IP
     GNC Network for PTTG1IP
     SABiosciences Custom PCR Arrays for PTTG1IP
     Search Tocris compounds for PTTG1IP (PTTG)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for PTTG1IP
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PTTG1IP antibodies
     PTTG1IP proteins
     PTTG1IP lysates
     Antibodies for PTTG1IP
     See all of Abcam's Antibodies, Kits and Proteins for PTTG1IP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PTTG1IP
     Antibodies for PTTG1IP
     ELISAs for PTTG1IP
     CLIAs for PTTG1IP
     Search LifeMap BioReagents cell lines for PTTG1IP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTTG1IP
     SwitchGear 3'UTR luciferase reporter plasmids for PTTG1IP
     SwitchGear Promoter luciferase reporter plasmids for PTTG1IP
     Search ThermoFisher Antibodies for PTTG1IP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTTG1IP
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PTTG1IP
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTTG1IP
    Customized:
     lentivirus for stable overexpression of PTTG1IP
     lentivirus expression plasmids for stable overexpression of PTTG1IP
     adenovirus for overexpression of PTTG1IP
     LSBio Antibodies in human, mouse, rat for PTTG1IP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PTTG1IP gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4