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PTTG1IP Gene

protein-coding   GIFtS: 53
GCID: GC21M046269

Pituitary Tumor-Transforming 1 Interacting Protein


(Previous symbols: C21orf3, C21orf1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Pituitary Tumor-Transforming 1 Interacting Protein1 2     Pituitary Tumor-Transforming Gene Protein-Binding Factor2 3
C21orf11 2 3 5     PTTG-Binding Factor2 3
C21orf31 2 3 5     Putative Surface Glycoprotein C21orf1 Precursor11
PBF2 3 5     Pituitary Tumor-Transforming Gene 1 Protein-Interacting Protein2

External Ids:    HGNC: 135241   Entrez Gene: 7542   Ensembl: ENSG000001832557   OMIM: 6037845   UniProtKB: P538013   

Export aliases for PTTG1IP gene to outside databases

Previous GC identifers: GC21M042779 GC21M045126 GC21M045125 GC21M045093 GC21M031643


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTTG1IP Gene:
This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1
protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1
induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants
have been found for this gene. (provided by RefSeq, Nov 2013)

GeneCards Summary for PTTG1IP Gene:
PTTG1IP (pituitary tumor-transforming 1 interacting protein) is a protein-coding gene. Diseases associated with PTTG1IP include pituitary tumors, and estrogen-receptor positive breast cancer.

UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801
Function: May facilitate PTTG1 nuclear translocation

Gene Wiki entry for PTTG1IP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTTG1IP gene promoter:
         TBP   c-Fos   HFH-3   AP-1   Brachyury   LCR-F1   C/EBPalpha   FOXI1   Egr-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PTTG1IP promoter sequence

   Search Chromatin IP Primers for PTTG1IP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTTG1IP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
PTTG1IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTTG1IP gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M046269:   GeneLoc Nature:405,311-319
Start:
46,269,500 bp from pter       31,778,924 bp from centromere
End:
46,293,818 bp from pter 31,803,008 bp from centromere
Size:
24,319 bases 24,085 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: Z50022
genomic clones: BAC-7B7


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801 (See protein sequence)
Recommended Name: Pituitary tumor-transforming gene 1 protein-interacting protein precursor  
Size: 180 amino acids; 20324 Da
Subunit: Interacts with PTTG1
Secondary accessions: B2RDP7 D3DSL9 Q9NS09

Explore the universe of human proteins at neXtProt for PTTG1IP: NX_P53801

Explore proteomics data for PTTG1IP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys164, Lys169
  • Glycosylation2 at Asn45, Asn54
  • Modification sites at PhosphoSitePlus

  • See PTTG1IP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273751.1  NP_004330.1  

    ENSEMBL proteins: 
     ENSP00000380984   ENSP00000328325   ENSP00000380983   ENSP00000395374  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR016201 Plexin-like_fold

    Graphical View of Domain Structure for InterPro Entry P53801

    ProtoNet protein and cluster: P53801

    UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801
    Similarity: Contains 1 PSI domain


    PTTG1IP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTTG_HUMAN, P53801
    Function: May facilitate PTTG1 nuclear translocation
    Induction: By transcription factor RUNX2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004872receptor activity IEA--
         
    PTTG1IP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTTG1IP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTTG1IP
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    miRNA
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    miRTarBase miRNAs that target PTTG1IP:
    hsa-mir-124-3p (MIRT002596), hsa-mir-98-5p (MIRT027698)

    Block miRNA regulation of human, mouse, rat PTTG1IP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTTG1IP (see all 9):
    hsa-miR-582-3p hsa-miR-3910 hsa-miR-647 hsa-miR-3163 hsa-miR-365 hsa-miR-105 hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidPTTG1IP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PTTG1IP

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTTG1IP

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTTG1IP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTTG_HUMAN, P53801: Membrane; Single-pass type I membrane protein (Potential). Cytoplasm. Nucleus.
    Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular3
    plasma membrane3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10781616
    GO:0005737cytoplasm IDA10781616
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    PTTG1IP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PTTG1IP
    Interactions:

        GeneGlobe Interaction Network for PTTG1IP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for PTTG1IP (P538013 ENSP000003283254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTTG1O959973, ENSP000003449364I2D: score=3 STRING: ENSP00000344936
    UBCENSP000003448184STRING: ENSP00000344818
    RAB4AENSP000003556514STRING: ENSP00000355651
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus IDA10781616
    GO:0007275multicellular organismal development IEA--

    PTTG1IP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTTG1IP (PTTG)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PTTG1IP gene (2 alternative transcripts): 
    NM_001286822.1  NM_004339.3  

    Unigene Cluster for PTTG1IP:

    Pituitary tumor-transforming 1 interacting protein
    Hs.474010  [show with all ESTs]
    Unigene Representative Sequence: AK095586
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397887 ENST00000330938(uc002zgb.2 uc011afk.2) ENST00000397886
    ENST00000474737 ENST00000494690 ENST00000480234 ENST00000445724
    miRNA
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    Block miRNA regulation of human, mouse, rat PTTG1IP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTTG1IP (see all 9):
    hsa-miR-582-3p hsa-miR-3910 hsa-miR-647 hsa-miR-3163 hsa-miR-365 hsa-miR-105 hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidPTTG1IP 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PTTG1IP (NM_004339)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTTG1IP
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    OriGene qPCR primer pairs and template standards for PTTG1IP
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTTG1IP
      QuantiTect SYBR Green Assays in human, mouse, rat PTTG1IP
      QuantiFast Probe-based Assays in human, mouse, rat PTTG1IP

    Additional mRNA sequence: 

    AF149785.1 AK094882.1 AK095586.1 AK290139.1 AK293318.1 AK298557.1 AK299204.1 AK315626.1 
    BC000415.2 BC012858.1 BC019295.1 BC020983.1 BC031097.1 BC034250.1 L48984.1 Z50022.1 

    Selected DOTS entries (see all 64):

    DT.92465796  DT.95371699  DT.95349475  DT.100884227  DT.92465818  DT.121133579  DT.100884232  DT.95371552 
    DT.100884215  DT.100884219  DT.100884217  DT.100884229  DT.100884225  DT.92465815  DT.100884234  DT.40206424 
    DT.121133564  DT.121133560  DT.121133603  DT.100884244  DT.121133504  DT.100738564  DT.100884226  DT.121133565 

    Selected AceView cDNA sequences (see all 1424):

    BG678434 BQ015387 AU130511 AW467466 AU131079 AU130850 BQ682394 CB139242 
    BU629735 BQ683868 BG178116 CD172089 BE744141 CA406720 T35812 BP367569 
    N67706 CB153485 AU130676 BP359400 BM558991 CB138139 BQ218259 BQ898346 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTTG1IP (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                          -     -     -     -     -           -     -                           
    SP2:                          -     -     -     -     -           -     -           -               
    SP3:                          -     -     -     -     -           -     -                           
    SP4:                                                  -           -     -     -                     
    SP5:                                                  -           -     -                           


    ECgene alternative splicing isoforms for PTTG1IP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTTG1IP expression in normal human tissues (normalized intensities)      PTTG1IP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACTGAGA
    PTTG1IP Expression
    About this image


    PTTG1IP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Medulla Oblongata
    PTTG1IP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTTG1IP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474010

    UniProtKB/Swiss-Prot: PTTG_HUMAN, P53801
    Tissue specificity: Ubiquitous

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    QuantiFast Probe-based Assays in human, mouse, rat PTTG1IP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTTG1IP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PTTG1IP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pttg1ip1 , 5 pituitary tumor-transforming 1 interacting protein1, 5 77.97(n)1
    74.71(a)1
      10 (39.72 cM)5
    1087051  NM_145925.21  NP_666037.11 
     775817205 
    chicken
    (Gallus gallus)
    Aves PTTG1IP1 pituitary tumor-transforming 1 interacting protein 59.77(n)
    61.38(a)
      420545  XM_418646.4  XP_418646.2 
    lizard
    (Anolis carolinensis)
    Reptilia PTTG1IP6
    pituitary tumor-transforming 1 interacting protein...
    66(a)
    1 ↔ 1
    3(33884693-33908531)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU901815.12   -- 74.23(n)    BU901815.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018862601 pituitary tumor-transforming gene 1 protein-interacting more 59.32(n)
    63.78(a)
      101886260  XM_005173546.1  XP_005173603.1 


    ENSEMBL Gene Tree for PTTG1IP (if available)
    TreeFam Gene Tree for PTTG1IP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTTG1IP (see all 790)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819730011,2
    --46269074(+) GGGCCA/GGGGTG 1 -- int10--------
    rs28387051,2
    C,F,O,H--46269114(+) AGACAC/GCCAGG 1 -- int114Minor allele frequency- G:0.25NA NS EA WA 921
    rs1421166441,2
    --46269150(+) GCGGGA/CGCCTC 1 -- int10--------
    rs754644391,2
    C,F--46269179(+) CACGGG/CGGGGC 1 -- int11Minor allele frequency- C:0.21WA 118
    rs1861487341,2
    --46269200(+) CTTCCC/TGAGGC 1 -- int10--------
    rs99777311,2
    C,F,A--46269214(+) CCTGCC/TTTCTC 1 -- int12Minor allele frequency- T:0.12WA NA 238
    rs1175992301,2
    C,F--46269224(+) CCCCCG/AGCCCT 1 -- int11Minor allele frequency- A:0.05EA 120
    rs1124468121,2
    C,F--46269242(+) CAGCGC/TGAGTG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1807145891,2
    --46269397(+) TCCCAC/TGATGG 1 -- int10--------
    rs2353111,2
    C,F,H--46269427(-) AGGCTT/GTTTTG 1 -- int110Minor allele frequency- G:0.11NS EA NA CSA 555

    HapMap Linkage Disequilibrium report for PTTG1IP (46269500 - 46293818 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTTG1IP (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv759e201CNV Deletion23290073
    esv2723686CNV Deletion23290073
    esv2723685CNV Deletion23290073
    esv2723688CNV Deletion23290073
    esv2577260CNV Insertion19546169
    dgv4778n71CNV Loss21882294
    nsv913963CNV Loss21882294
    nsv459298CNV Loss19166990
    nsv913967CNV Loss21882294
    dgv4775n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): PTTG1IP
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603784    OMIM disorders: --

    13 diseases for PTTG1IP:    About MalaCards
    pituitary tumors    estrogen-receptor positive breast cancer    pituitary adenoma    intrahepatic cholangiocarcinoma
    papillary thyroid carcinoma    cholangiocarcinoma    astrocytoma    adenoma
    thyroiditis    hepatitis b    hepatocellular carcinoma    breast cancer
    hepatitis


    PTTG1IP for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PTTG1IP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary tumors 69.7 3 20406982 (1), 15886233 (1)


    Export disorders for PTTG1IP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTTG1IP gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with PTTG1IP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3. (PubMed id 9570958)1, 2, 3, 9 Yaspo M.-L....Lehrach H. (Genomics 1998)
    2. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2, 3 Hattori M.... Yaspo M.-L. (Nature 2000)
    3. A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor- transforming gene product. (PubMed id 10781616)1, 2, 9 Chien W. and Pei L. (J. Biol. Chem. 2000)
    4. Identification of novel genes of the bone-specific transcription factor Runx2. (PubMed id 15190888)1, 2 Stock M.... Otto F. (J. Bone Miner. Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. (PubMed id 15178645)1, 9 Tfelt-Hansen J....Chattopadhyay N. (Endocrinology 2004)
    8. A potential role for PTTG/securin in the developing human fetal brain. (PubMed id 12958169)1, 9 Boelaert K....McCabe C.J. (FASEB J. 2003)
    9. Manipulation of PBF/PTTG1IP phosphorylation status; a potential new therapeutic strategy for improving radioiodine uptake in thyroid and other tumors. (PubMed id 23678037)1 Smith V.E....McCabe C.J. (J. Clin. Endocrinol. Metab. 2013)
    10. Prognostic significance of pituitary tumour-transforming gene-binding factor (PBF) expression in papillary thyroid carcinoma. (PubMed id 22888961)1 Hsueh C....Ueng S.H. (Clin. Endocrinol. (Oxf) 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 754 HGNC: 13524 AceView: PTTG1IP Ensembl:ENSG00000183255 euGenes: HUgn754
    ECgene: PTTG1IP H-InvDB: PTTG1IP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTTG1IP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTTG1IP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTTG1IP gene:
    Search GeneIP for patents involving PTTG1IP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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