Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PTTG1 Gene

Aliases for PTTG1 Gene

  • Pituitary Tumor-Transforming 1 2 3
  • Tumor-Transforming Protein 1 2 3 4
  • TUTR1 3 4 6
  • EAP1 3 4 6
  • Pituitary Tumor-Transforming Gene 1 Protein 3 4
  • ESP1-Associated Protein 1 2 3
  • HPTTG 3 4
  • PTTG 3 4
  • Esp1-Associated Protein 4
  • Securin 3

External Ids for PTTG1 Gene

Previous HGNC Symbols for PTTG1 Gene

  • TUTR1

Previous GeneCards Identifiers for PTTG1 Gene

  • GC05P159967
  • GC05P160358
  • GC05P159784
  • GC05P159829
  • GC05P159781
  • GC05P154942
  • GC05P159850

Summaries for PTTG1 Gene

Entrez Gene Summary for PTTG1 Gene

  • The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for PTTG1 Gene

PTTG1 (Pituitary Tumor-Transforming 1) is a Protein Coding gene. Diseases associated with PTTG1 include thymic hyperplasia and thyroid cancer. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is PTTG2.

UniProtKB/Swiss-Prot for PTTG1 Gene

  • Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Gene Wiki entry for PTTG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTTG1 Gene

Genomics for PTTG1 Gene

Regulatory Elements for PTTG1 Gene

Genomic Location for PTTG1 Gene

Start:
160,421,807 bp from pter
End:
160,428,744 bp from pter
Size:
6,938 bases
Orientation:
Plus strand

Genomic View for PTTG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTTG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTTG1 Gene

Proteins for PTTG1 Gene

  • Protein details for PTTG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95997-PTTG1_HUMAN
    Recommended name:
    Securin
    Protein Accession:
    O95997
    Secondary Accessions:

    Protein attributes for PTTG1 Gene

    Size:
    202 amino acids
    Molecular mass:
    22024 Da
    Quaternary structure:
    • Interacts with RPS10 and DNAJA1 (By similarity). Interacts with the caspase-like ESPL1, and prevents its protease activity probably by covering its active site. Interacts with TP53 and blocks its activity probably by blocking its binding to DNA. Interacts with the Ku 70 kDa subunit of ds-DNA kinase. Interacts with PTTG1IP.

neXtProt entry for PTTG1 Gene

Proteomics data for PTTG1 Gene at MOPED

Post-translational modifications for PTTG1 Gene

  • Phosphorylated at Ser-165 by CDK1 during mitosis.
  • Phosphorylated in vitro by ds-DNA kinase.
  • Ubiquitinated through Lys-11 linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. Lys-11-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTTG1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTTG1 (Securin)

No data available for DME Specific Peptides for PTTG1 Gene

Domains for PTTG1 Gene

Protein Domains for PTTG1 Gene

Graphical View of Domain Structure for InterPro Entry

O95997

UniProtKB/Swiss-Prot:

PTTG1_HUMAN :
  • O95997
Domain:
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • The TEK-boxes are required for Lys-11-linked ubiquitination and facilitate the transfer of the first ubiquitin and ubiquitin chain nucleation. TEK-boxes may direct a catalytically competent orientation of the UBE2C/UBCH10-ubiquitin thioester with the acceptor lysine residue.
Family:
  • Belongs to the securin family.
genes like me logo Genes that share domains with PTTG1: view

No data available for Gene Families for PTTG1 Gene

Function for PTTG1 Gene

Molecular function for PTTG1 Gene

GENATLAS Biochemistry: rat pituitary tumor transforming 1,overexpressed in Jurkat cells and in several hematopoietic malignancies,mainly located in cytosol but partly in nucleus,expressed in normal adult testis,thymus,colon,brain,lung and fetal liver
UniProtKB/Swiss-Prot Function: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Gene Ontology (GO) - Molecular Function for PTTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9811450
GO:0004869 cysteine-type endopeptidase inhibitor activity NAS 12194817
GO:0005515 protein binding IPI 12194817
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with PTTG1: view
genes like me logo Genes that share phenotypes with PTTG1: view

Animal Models for PTTG1 Gene

MGI Knock Outs for PTTG1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTTG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PTTG1 Gene

Localization for PTTG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTTG1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTTG1 Gene COMPARTMENTS Subcellular localization image for PTTG1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PTTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 9811450
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PTTG1: view

Pathways for PTTG1 Gene

genes like me logo Genes that share pathways with PTTG1: view

Pathways by source for PTTG1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006281 DNA repair IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 9811450
GO:0006366 transcription from RNA polymerase II promoter TAS 9811450
GO:0007059 chromosome segregation IEA --
genes like me logo Genes that share ontologies with PTTG1: view

Compounds for PTTG1 Gene

(12) Novoseek inferred chemical compound relationships for PTTG1 Gene

Compound -log(P) Hits PubMed IDs
ag 1478 31.4 2
nocodazole 29 1
vegf 25.9 22
ribonucleic acid 15.5 3
agar 13.5 2
genes like me logo Genes that share compounds with PTTG1: view

Transcripts for PTTG1 Gene

Unigene Clusters for PTTG1 Gene

Pituitary tumor-transforming 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTTG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTTG1 Gene

No ASD Table

Relevant External Links for PTTG1 Gene

GeneLoc Exon Structure for
PTTG1
ECgene alternative splicing isoforms for
PTTG1

Expression for PTTG1 Gene

mRNA expression in normal human tissues for PTTG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTTG1 Gene

This gene is overexpressed in Testis (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTTG1 Gene

SOURCE GeneReport for Unigene cluster for PTTG1 Gene Hs.350966

mRNA Expression by UniProt/SwissProt for PTTG1 Gene

O95997-PTTG1_HUMAN
Tissue specificity: Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer.
genes like me logo Genes that share expressions with PTTG1: view

In Situ Assay Products

Orthologs for PTTG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTTG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTTG1 35
  • 99.5 (n)
  • 99.5 (a)
PTTG1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 86 (a)
ManyToMany
-- 36
  • 80 (a)
ManyToMany
LOC100848911 35
  • 88.23 (n)
  • 85.57 (a)
PTTG1 36
  • 86 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
OneToMany
PTTG1 35
  • 88.23 (n)
  • 84.58 (a)
mouse
(Mus musculus)
Mammalia Pttg1 35
  • 79.4 (n)
  • 72.86 (a)
Pttg1 16
Pttg1 36
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pttg1 35
  • 79.73 (n)
  • 72.36 (a)
chicken
(Gallus gallus)
Aves PTTG1 35
  • 60.25 (n)
  • 49.2 (a)
PTTG1 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498440 35
  • 48.15 (n)
  • 37.57 (a)
Species with no ortholog for PTTG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTTG1 Gene

ENSEMBL:
Gene Tree for PTTG1 (if available)
TreeFam:
Gene Tree for PTTG1 (if available)

Paralogs for PTTG1 Gene

Paralogs for PTTG1 Gene

Selected SIMAP similar genes for PTTG1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PTTG1 Gene

genes like me logo Genes that share paralogs with PTTG1: view

Variants for PTTG1 Gene

Sequence variations from dbSNP and Humsavar for PTTG1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7335 -- 160,428,637(+) CGACC(C/T)TGGAT reference, synonymous-codon
rs1057851 -- 160,427,848(+) GTGAA(A/G)ATGCC synonymous-codon, reference
rs1802499 -- 160,427,794(+) CTTGA(C/T)GAGGA reference, synonymous-codon
rs1802500 -- 160,422,816(+) GAACT(G/T)TCAAC reference, missense
rs1862391 -- 160,421,460(-) AATAC(G/T)AGCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PTTG1 Gene

Variant ID Type Subtype PubMed ID
nsv883072 CNV Loss 21882294

Relevant External Links for PTTG1 Gene

HapMap Linkage Disequilibrium report
PTTG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTTG1 Gene

Disorders for PTTG1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for PTTG1 Gene including...

Search for PTTG1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for PTTG1 Gene

(34) Novoseek inferred disease relationships for PTTG1 Gene

Disease -log(P) Hits PubMed IDs
pituitary tumors 90.2 91
pituitary adenoma 78.9 47
prolactinoma 58.9 8
thyroid cancer 55.1 11
follicular thyroid cancer 54.3 1

Relevant External Links for PTTG1

Genetic Association Database (GAD)
PTTG1
Human Genome Epidemiology (HuGE) Navigator
PTTG1
genes like me logo Genes that share disorders with PTTG1: view

No data available for UniProtKB/Swiss-Prot for PTTG1 Gene

Publications for PTTG1 Gene

  1. Structure, expression, and function of human pituitary tumor- transforming gene (PTTG). (PMID: 9892021) Zhang X. … Melmed S. (Mol. Endocrinol. 1999) 2 3 4 23
  2. Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. (PMID: 10022450) Zhang X. … Melmed S. (J. Clin. Endocrinol. Metab. 1999) 3 4 23
  3. Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis. (PMID: 10393434) Kakar S.S. … Jennes L. (Cytogenet. Cell Genet. 1999) 3 4 23
  4. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. (PMID: 10411507) Zou H. … Kirschner M.W. (Science 1999) 3 4 23
  5. A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor- transforming gene product. (PMID: 10781616) Chien W. … Pei L. (J. Biol. Chem. 2000) 3 4 23

Products for PTTG1 Gene

  • Addgene plasmids for PTTG1

Sources for PTTG1 Gene

Back to Top

Content