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Aliases for PTTG1 Gene

Aliases for PTTG1 Gene

  • Pituitary Tumor-Transforming 1 2 3 5
  • Tumor-Transforming Protein 1 2 3 4
  • Pituitary Tumor-Transforming Gene 1 Protein 3 4
  • ESP1-Associated Protein 1 2 3
  • HPTTG 3 4
  • TUTR1 3 4
  • EAP1 3 4
  • PTTG 3 4
  • Esp1-Associated Protein 4
  • Securin 3

External Ids for PTTG1 Gene

Previous HGNC Symbols for PTTG1 Gene

  • TUTR1

Previous GeneCards Identifiers for PTTG1 Gene

  • GC05P159967
  • GC05P160358
  • GC05P159784
  • GC05P159829
  • GC05P159781
  • GC05P154942
  • GC05P159850

Summaries for PTTG1 Gene

Entrez Gene Summary for PTTG1 Gene

  • The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

CIViC summary for PTTG1 Gene

GeneCards Summary for PTTG1 Gene

PTTG1 (Pituitary Tumor-Transforming 1) is a Protein Coding gene. Diseases associated with PTTG1 include Thyroid Cancer and Thymic Hyperplasia. Among its related pathways are Cell cycle and Oocyte meiosis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is PTTG2.

UniProtKB/Swiss-Prot for PTTG1 Gene

  • Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Gene Wiki entry for PTTG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTTG1 Gene

Genomics for PTTG1 Gene

Regulatory Elements for PTTG1 Gene

Enhancers for PTTG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G160417 1 ENCODE 17.1 -2.6 -2625 2.8 HDGF PKNOX1 ATF1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 BRCA1 ZNF48 PTTG1 SLU7 ZBED8
GH05G160421 1 ENCODE 17 +0.7 694 2.6 WRNIP1 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 ZNF766 GATA2 ZNF143 PTTG1 SLU7 GC05M160425
GH05G160433 1.4 FANTOM5 Ensembl ENCODE 10.6 +12.1 12128 1.0 HDGF ZNF76 BMI1 FEZF1 ZNF2 EGR1 ZNF366 ZNF143 RELB IKZF2 MIR146A PTTG1 SLU7 FABP6 PWWP2A GC05P160436 GC05M160425
GH05G160424 0.4 Ensembl 0.7 +3.2 3194 0.4 ZMYM3 MIR146A GC05M160425 PTTG1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTTG1 on UCSC Golden Path with GeneCards custom track

Promoters for PTTG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000189980 193 1201 WRNIP1 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 ZNF766 GATA2 ZNF143

Genomic Location for PTTG1 Gene

Chromosome:
5
Start:
160,421,807 bp from pter
End:
160,428,744 bp from pter
Size:
6,938 bases
Orientation:
Plus strand

Genomic View for PTTG1 Gene

Genes around PTTG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTTG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTTG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTTG1 Gene

Proteins for PTTG1 Gene

  • Protein details for PTTG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95997-PTTG1_HUMAN
    Recommended name:
    Securin
    Protein Accession:
    O95997

    Protein attributes for PTTG1 Gene

    Size:
    202 amino acids
    Molecular mass:
    22024 Da
    Quaternary structure:
    • Interacts with RPS10 and DNAJA1 (By similarity). Interacts with the caspase-like ESPL1, and prevents its protease activity probably by covering its active site. Interacts with TP53 and blocks its activity probably by blocking its binding to DNA. Interacts with the Ku 70 kDa subunit of ds-DNA kinase. Interacts with PTTG1IP.

neXtProt entry for PTTG1 Gene

Post-translational modifications for PTTG1 Gene

  • Phosphorylated at Ser-165 by CDK1 during mitosis.
  • Phosphorylated in vitro by ds-DNA kinase.
  • Ubiquitinated through Lys-11 linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. Lys-11-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTTG1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTTG1 (Securin)
  • Cloud-Clone Corp. Antibodies for PTTG1

No data available for DME Specific Peptides for PTTG1 Gene

Domains & Families for PTTG1 Gene

Protein Domains for PTTG1 Gene

Graphical View of Domain Structure for InterPro Entry

O95997

UniProtKB/Swiss-Prot:

PTTG1_HUMAN :
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the securin family.
Domain:
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • The TEK-boxes are required for Lys-11-linked ubiquitination and facilitate the transfer of the first ubiquitin and ubiquitin chain nucleation. TEK-boxes may direct a catalytically competent orientation of the UBE2C/UBCH10-ubiquitin thioester with the acceptor lysine residue.
Family:
  • Belongs to the securin family.
genes like me logo Genes that share domains with PTTG1: view

No data available for Gene Families for PTTG1 Gene

Function for PTTG1 Gene

Molecular function for PTTG1 Gene

GENATLAS Biochemistry:
rat pituitary tumor transforming 1,overexpressed in Jurkat cells and in several hematopoietic malignancies,mainly located in cytosol but partly in nucleus,expressed in normal adult testis,thymus,colon,brain,lung and fetal liver
UniProtKB/Swiss-Prot Function:
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Gene Ontology (GO) - Molecular Function for PTTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IMP 9811450
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9811450
GO:0004869 cysteine-type endopeptidase inhibitor activity NAS 12194817
GO:0005515 protein binding IPI 12194817
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with PTTG1: view
genes like me logo Genes that share phenotypes with PTTG1: view

Animal Models for PTTG1 Gene

MGI Knock Outs for PTTG1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTTG1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTTG1 Gene

Localization for PTTG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTTG1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTTG1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PTTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 9811450
GO:0005737 cytoplasm TAS 9811450
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PTTG1: view

Pathways & Interactions for PTTG1 Gene

genes like me logo Genes that share pathways with PTTG1: view

SIGNOR curated interactions for PTTG1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PTTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IMP,TAS 9811450
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with PTTG1: view

Drugs & Compounds for PTTG1 Gene

(7) Drugs for PTTG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for PTTG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PTTG1: view

Transcripts for PTTG1 Gene

Unigene Clusters for PTTG1 Gene

Pituitary tumor-transforming 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTTG1

Alternative Splicing Database (ASD) splice patterns (SP) for PTTG1 Gene

No ASD Table

Relevant External Links for PTTG1 Gene

GeneLoc Exon Structure for
PTTG1
ECgene alternative splicing isoforms for
PTTG1

Expression for PTTG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTTG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTTG1 Gene

This gene is overexpressed in Testis (x9.7).

Protein differential expression in normal tissues from HIPED for PTTG1 Gene

This gene is overexpressed in Testis (40.9) and Fetal Liver (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTTG1 Gene



Protein tissue co-expression partners for PTTG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTTG1 Gene:

PTTG1

SOURCE GeneReport for Unigene cluster for PTTG1 Gene:

Hs.350966

mRNA Expression by UniProt/SwissProt for PTTG1 Gene:

O95997-PTTG1_HUMAN
Tissue specificity: Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer.

Evidence on tissue expression from TISSUES for PTTG1 Gene

  • Nervous system(2.8)
  • Thyroid gland(2.5)
  • Lymph node(2.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with PTTG1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTTG1 Gene

Orthologs for PTTG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTTG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTTG1 34 35
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia LOC100848911 34
  • 88.23 (n)
-- 35
  • 86 (a)
ManyToMany
PTTG1 35
  • 86 (a)
ManyToMany
-- 35
  • 80 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia PTTG1 34
  • 88.23 (n)
-- 35
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pttg1 34
  • 79.73 (n)
mouse
(Mus musculus)
Mammalia Pttg1 34 16 35
  • 79.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves PTTG1 34 35
  • 60.25 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498440 34
  • 48.15 (n)
Species where no ortholog for PTTG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTTG1 Gene

ENSEMBL:
Gene Tree for PTTG1 (if available)
TreeFam:
Gene Tree for PTTG1 (if available)

Paralogs for PTTG1 Gene

Paralogs for PTTG1 Gene

(3) SIMAP similar genes for PTTG1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PTTG1 Gene

genes like me logo Genes that share paralogs with PTTG1: view

Variants for PTTG1 Gene

Sequence variations from dbSNP and Humsavar for PTTG1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000033782 -- 160,426,388(+) TCACA(C/T)AGATA intron-variant
rs1000289158 -- 160,425,846(+) ATTCT(C/T)GAGTA intron-variant
rs1000928629 -- 160,421,366(+) CAGTT(A/C)GTTCT upstream-variant-2KB
rs1001035771 -- 160,427,858(+) CCTCT(C/T)CACCA reference, missense
rs1001151387 -- 160,427,490(+) TAATA(C/T)GGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTTG1 Gene

Variant ID Type Subtype PubMed ID
esv3607370 CNV gain 21293372
nsv1015634 CNV gain 25217958

Variation tolerance for PTTG1 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTTG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTTG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTTG1 Gene

Disorders for PTTG1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PTTG1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thyroid cancer
  • malignant neoplasm of thyroid gland
thymic hyperplasia
  • hyperplasia of thymus gland
thyroid cancer, nonmedullary, 2
  • thyroid carcinoma, follicular, somatic
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PTTG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTTG1

Genetic Association Database (GAD)
PTTG1
Human Genome Epidemiology (HuGE) Navigator
PTTG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTTG1
genes like me logo Genes that share disorders with PTTG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTTG1 Gene

Publications for PTTG1 Gene

  1. Structure, expression, and function of human pituitary tumor- transforming gene (PTTG). (PMID: 9892021) Zhang X. … Melmed S. (Mol. Endocrinol. 1999) 2 3 4 22 64
  2. Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis. (PMID: 12355087) Bernal J.A. … Pintor-Toro J.A. (Nat. Genet. 2002) 3 4 22 64
  3. Human pituitary tumor-transforming gene induces angiogenesis. (PMID: 11158059) Ishikawa H. … Melmed S. (J. Clin. Endocrinol. Metab. 2001) 3 4 22 64
  4. Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase. (PMID: 11238996) Romero F. … Tortolero M. (Nucleic Acids Res. 2001) 3 4 22 64
  5. A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor- transforming gene product. (PMID: 10781616) Chien W. … Pei L. (J. Biol. Chem. 2000) 3 4 22 64

Products for PTTG1 Gene

  • Addgene plasmids for PTTG1

Sources for PTTG1 Gene

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