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PTTG1 Gene

protein-coding   GIFtS: 62
GCID: GC05P159850

Pituitary Tumor-Transforming 1


(Previous symbol: TUTR1)
  See PTTG1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pituitary Tumor-Transforming 11 2     PTTG2 3
TUTR11 2 3 5     HPTTG2
Tumor-Transforming Protein 11 2 3     securin2
EAP12 3 5     Esp1-Associated Protein3
ESP1-Associated Protein 11 2     hPTTG3
Pituitary Tumor-Transforming Gene 1 Protein2 3     

External Ids:    HGNC: 96901   Entrez Gene: 92322   Ensembl: ENSG000001646117   OMIM: 6041475   UniProtKB: O959973   

Export aliases for PTTG1 gene to outside databases

Previous GC identifers: GC05P159967 GC05P160358 GC05P159784 GC05P159829 GC05P159781 GC05P154942


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTTG1 Gene:
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid
separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation
of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is
highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its
transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor
expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The
acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a
cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same
protein have been found for this gene. (provided by RefSeq, Sep 2013)

GeneCards Summary for PTTG1 Gene:
PTTG1 (pituitary tumor-transforming 1) is a protein-coding gene. Diseases associated with PTTG1 include thymic hyperplasia, and thyroid cancer. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is PTTG2.

UniProtKB/Swiss-Prot: PTTG1_HUMAN, O95997
Function: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA
repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1
function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At
the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its
function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively
regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53
may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in
DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid
separation

Gene Wiki entry for PTTG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTTG1 gene promoter:
         Nkx3-1 v4   Elk-1   PPAR-gamma1   Sp1   Lmo2   PPAR-gamma2   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTTG1 promoter sequence
   Search Chromatin IP Primers for PTTG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTTG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q35.1

PTTG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTTG1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P159850:  view genomic region     (about GC identifiers)

Start:
159,848,829 bp from pter      End:
159,855,748 bp from pter
Size:
6,920 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PTTG1_HUMAN, O95997 (See protein sequence)
Recommended Name: Securin  
Size: 202 amino acids; 22024 Da
Subunit: Interacts with RPS10 and DNAJA1 (By similarity). Interacts with the caspase-like ESPL1, and prevents its
protease activity probably by covering its active site. Interacts with TP53 and blocks its activity probably by
blocking its binding to DNA. Interacts with the Ku 70 kDa subunit of ds-DNA kinase. Interacts with PTTG1IP
Developmental stage: Low level during G1 and S phases. Peaks at M phase. During anaphase, it is degraded

Explore the universe of human proteins at neXtProt for PTTG1: NX_O95997

Explore proteomics data for PTTG1 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-165 by CDK1 during mitosis1
  • Phosphorylated in vitro by ds-DNA kinase1
  • Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset
    of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase
    UBE2C/UBCH101
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PTTG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269311.1  NP_001269312.1  NP_004210.1  

    ENSEMBL proteins: 
     ENSP00000344936   ENSP00000431068   ENSP00000430642   ENSP00000377536  
    Reactome Protein details: O95997

    PTTG1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. ELISAs for PTTG1
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    Search eBioscience for ELISAs for PTTG1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018008 Securin_separation-inh_met
     IPR006940 Securin_separation_inhibitor

    Graphical View of Domain Structure for InterPro Entry O95997

    ProtoNet protein and cluster: O95997

    UniProtKB/Swiss-Prot: PTTG1_HUMAN, O95997
    Domain: The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the
    ubiquitin-proteasome pathway (By similarity)
    Domain: The TEK-boxes are required for 'Lys-11'-linked ubiquitination and facilitate the transfer of the first
    ubiquitin and ubiquitin chain nucleation. TEK-boxes may direct a catalytically competent orientation of the
    UBE2C/UBCH10-ubiquitin thioester with the acceptor lysine residue
    Similarity: Belongs to the securin family


    Find genes that share domains with PTTG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTTG1_HUMAN, O95997
    Function: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA
    repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1
    function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At
    the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its
    function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively
    regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53
    may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in
    DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid
    separation

         Genatlas biochemistry entry for PTTG1:
    rat pituitary tumor transforming 1,overexpressed in Jurkat cells and in several hematopoietic malignancies,mainly
    located in cytosol but partly in nucleus,expressed in normal adult testis,thymus,colon,brain,lung and fetal liver

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9811450
    GO:0004869cysteine-type endopeptidase inhibitor activity NAS12194817
    GO:0005515protein binding IPI12194817
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with PTTG1           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Pttg1):
     adipose tissue  behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     nervous system  no phenotypic analysis  renal/urinary system  reproductive system 

    Find genes that share phenotypes with PTTG1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTTG1: Pttg1tm1.2Kna Pttg1tm1.1Tno Pttg1tm1Pzg Pttg1tm1Sme

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTTG1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTTG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTTG1

    miRNA
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    miRTarBase miRNAs that target PTTG1:
    hsa-mir-320a (MIRT044427), hsa-mir-186-5p (MIRT044923), hsa-mir-423-5p (MIRT038103), hsa-let-7b-5p (MIRT052149), hsa-mir-17-5p (MIRT050987), hsa-mir-26a-5p (MIRT050118)

    Block miRNA regulation of human, mouse, rat PTTG1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PTTG1:
    hsa-miR-374c hsa-miR-655
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Addgene plasmids for PTTG1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTTG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTTG1_HUMAN, O95997: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS9811450
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PTTG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTTG1 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    APC/C-Cdc20 mediated degradation of mitotic proteins0.93
    Regulation of mitotic cell cycle0.94
    APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G10.93
    APC/C-Cdc20 mediated degradation of Securin0.93
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    3Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Oocyte meiosis
    Oocyte meiosis0.35


    Find genes that share SuperPaths with PTTG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTTG1
        Mitotic Roles of Polo Like Kinases

    2 GeneGo (Thomson Reuters) Pathways for PTTG1
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Spindle assembly and chromosome separation

    2 BioSystems Pathways for PTTG1
        Cell cycle
    Integrated Pancreatic Cancer Pathway


    3 Reactome Pathways for PTTG1
        APC/C:Cdc20 mediated degradation of Securin
    Separation of Sister Chromatids
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1


    3 Kegg Pathways  (Kegg details for PTTG1):
        Cell cycle
    Oocyte meiosis
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTTG1: 
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTTG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTTG1 (O959973 ENSP000003449364) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESPL1Q146743, ENSP000002579344I2D: score=4 STRING: ENSP00000257934
    TP53P046373, ENSP000002693054I2D: score=4 STRING: ENSP00000269305
    DNAJA1P316893, ENSP000003691274I2D: score=3 STRING: ENSP00000369127
    PTTG1IPP538013, ENSP000003283254I2D: score=3 STRING: ENSP00000328325
    XRCC6P129563, ENSP000003522574I2D: score=3 STRING: ENSP00000352257
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006259DNA metabolic process ----
    GO:0006281DNA repair IEA--
    GO:0006355regulation of transcription, DNA-templated TAS9811450
    GO:0006366transcription from RNA polymerase II promoter TAS9811450

    Find genes that share ontologies with PTTG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTTG1

    Selected Novoseek inferred chemical compound relationships for PTTG1 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ag 1478 31.4 2 16959877 (1), 15178645 (1)
    nocodazole 29 1 17197431 (1)
    vegf 25.9 32 12590639 (7), 12213878 (4), 15649325 (3), 16926250 (2) (see all 8)
    ribonucleic acid 15.5 4 11158059 (1), 12324572 (1), 12970167 (1)
    agar 13.5 3 14709851 (1), 15649325 (1)
    proline 9.38 3 9892021 (2), 15929994 (1)
    estrogen 9.29 15 17222350 (3), 10546001 (2), 18217976 (1), 11805140 (1) (see all 5)
    dopamine 5.07 3 16411064 (1), 18791324 (1)
    calcium 4.95 4 12970167 (2), 17882219 (1)
    phosphatidylinositol 3.66 4 19549593 (1), 15922332 (1), 17107960 (1)



    Find genes that share compounds with PTTG1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTTG1 gene (3 alternative transcripts): 
    NM_001282382.1  NM_001282383.1  NM_004219.3  

    Unigene Cluster for PTTG1:

    Pituitary tumor-transforming 1
    Hs.350966  [show with all ESTs]
    Unigene Representative Sequence: BE904476
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000352433(uc003lyj.3) ENST00000524244 ENST00000517480 ENST00000523659
    ENST00000520452 ENST00000393964(uc003lyk.3) ENST00000519287
    miRNA
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    hsa-miR-374c hsa-miR-655
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    OriGene qPCR primer pairs and template standards for PTTG1
    OriGene qSTAR qPCR primer pairs in human, mouse for PTTG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTTG1
      QuantiTect SYBR Green Assays in human, mouse, rat PTTG1
      QuantiFast Probe-based Assays in human, mouse, rat PTTG1

    Additional mRNA sequence: 

    AF062649.1 AF075242.1 AF095287.1 AJ223953.1 AK312209.1 BC026003.1 BC101834.1 BC108894.1 
    BC108895.1 BC112071.1 BC113842.1 BC113896.1 BC128193.1 BC128194.1 CR457135.1 CR541685.1 

    15 DOTS entries:

    DT.456008  DT.100793413  DT.100793412  DT.102825886  DT.95249453  DT.91937026  DT.99984804  DT.100793410 
    DT.120875033  DT.99983395  DT.120874968  DT.95093366  DT.95093390  DT.99992318  DT.91938081 

    Selected AceView cDNA sequences (see all 301):

    BM548937 AA081273 BM014026 BM461796 CB143123 AI052735 BM476778 BF797308 
    BI256425 AA555210 N23584 BI827526 AV760223 AI498735 H58303 BM784799 
    AA286786 AA041520 AA477063 BM785163 BG574097 BQ575822 BQ436778 H77519 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTTG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATCCAAT
    PTTG1 Expression
    About this image


    PTTG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Testis (Reproductive System)
    PTTG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTTG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.350966

    UniProtKB/Swiss-Prot: PTTG1_HUMAN, O95997
    Tissue specificity: Expressed at low level in most tissues, except in adult testis, where it is highly expressed.
    Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal
    cancer

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PTTG1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pttg11 , 5 pituitary tumor-transforming gene 11, 5 79.4(n)1
    72.86(a)1
      11 (25.68 cM)5
    309391  NM_001131054.11  NP_001124526.11 
     434202505 
    chicken
    (Gallus gallus)
    Aves PTTG11 pituitary tumor-transforming 1 60.25(n)
    49.2(a)
      416158  NM_001277740.1  NP_001264669.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    1 → many
    GL343286.1(1238598-1251011)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004984401 securin-like 48.15(n)
    37.57(a)
      100498440  XM_004913488.1  XP_004913545.1 


    ENSEMBL Gene Tree for PTTG1 (if available)
    TreeFam Gene Tree for PTTG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTTG1 gene
    PTTG22  
    3 SIMAP similar genes for PTTG1 using alignment to 5 protein entries:     PTTG1_HUMAN (see all proteins):
    PTTG    PTTG2    PTTG3P

    Find genes that share paralogs with PTTG1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for PTTG1
    PGOHUM00000242319 PGOHUM00000232606 PGOHUM00000257190


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTTG1 (see all 170)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1807976001,2
    --159848186(+) GTTAAC/TATATT 1 -- us2k10--------
    rs18623921,2
    C--159848193(-) TCTCAA/TTAATA 1 -- us2k1 tfbs34Minor allele frequency- T:0.18NA WA EA 360
    rs120547731,2
    C,F,H--159848287(+) TGTTCC/TTAAGA 1 -- us2k16Minor allele frequency- T:0.01NS NA 900
    rs1489497951,2
    C--159848317(+) TAGAA-/ACAGTGT 1 -- us2k10--------
    rs1850624751,2
    C--159848375(+) GTTCGC/TTCTTA 1 -- us2k10--------
    rs18623911,2
    C,F,H--159848467(-) AATACT/GAGCAG 1 -- us2k116Minor allele frequency- G:0.18NS EA NA WA 2336
    rs1894543371,2
    --159848913(+) TGGGAA/GGGTCG 1 -- int10--------
    rs1382218561,2
    C--159848977(+) CTGGG-/GCTGAA
            
    GCTGA
    1 -- cds10--------
    rs1398114881,2
    --159849053(+) TCGGAC/TTGCTA 1 -- int10--------
    rs1816076441,2
    --159849176(+) TGGCTC/TACGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for PTTG1 (159848829 - 159855748 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PTTG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883072CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTTG1
    DNA2.0 Custom Variant and Variant Library Synthesis for PTTG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604147    OMIM disorders: --

    2 diseases for PTTG1:    
    About MalaCards
    thymic hyperplasia    thyroid cancer

    2 diseases from the University of Copenhagen DISEASES database for PTTG1:
    Cancer     Adenoma

    Find genes that share disorders with PTTG1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PTTG1 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary tumors 90.2 128 17652795 (4), 10022450 (4), 14709851 (3), 11805140 (3) (see all 60)
    pituitary adenoma 78.9 60 16984249 (5), 20106827 (4), 12580929 (4), 12580928 (3) (see all 23)
    prolactinoma 58.9 9 17222350 (3), 16411064 (1), 10546001 (1), 12554778 (1) (see all 6)
    thyroid cancer 55.1 11 12727994 (2), 16759264 (2), 15897900 (2), 16926250 (1) (see all 8)
    follicular thyroid cancer 54.3 1 17127711 (1)
    adenoma 53.2 15 16447816 (3), 12580928 (2), 20106827 (2), 12590639 (2) (see all 8)
    tumors 47.8 188 17096843 (6), 10393434 (5), 15649325 (5), 17029632 (5) (see all 64)
    aggressiveness 44.2 6 17306208 (1), 16418208 (1), 18791324 (1), 14759723 (1) (see all 5)
    macroprolactinoma 43.6 1 17222350 (1)
    cancer 43.1 40 20457353 (3), 10084610 (2), 16809406 (2), 16219911 (2) (see all 20)

    Genetic Association Database (GAD): PTTG1
    Human Genome Epidemiology (HuGE) Navigator: PTTG1 (9 documents)

    Export disorders for PTTG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTTG1 gene, integrated from 10 sources (see all 318):
    (articles sorted by number of sources associating them with PTTG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, expression, and function of human pituitary tumor- transforming gene (PTTG). (PubMed id 9892021)1, 2, 3, 9 Zhang X.... Melmed S. (Mol. Endocrinol. 1999)
    2. hPTTG, a human homologue of rat PTTG, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. (PubMed id 9811450)1, 2, 3 Dominguez A.... Pintor-Toro J.A. (Oncogene 1998)
    3. Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis. (PubMed id 12355087)1, 2, 9 Bernal J.A.... Pintor-Toro J.A. (Nat. Genet. 2002)
    4. Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. (PubMed id 10022450)1, 2, 9 Zhang X.... Melmed S. (J. Clin. Endocrinol. Metab. 1999)
    5. Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG). (PubMed id 10580151)1, 2, 9 Kakar S.S. (Gene 1999)
    6. Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase. (PubMed id 11238996)1, 2, 9 Romero F.... Tortolero M. (Nucleic Acids Res. 2001)
    7. A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor- transforming gene product. (PubMed id 10781616)1, 2, 9 Chien W. and Pei L. (J. Biol. Chem. 2000)
    8. Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis. (PubMed id 10393434)1, 2, 9 Kakar S.S. and Jennes L. (Cytogenet. Cell Genet. 1999)
    9. Human pituitary tumor-transforming gene induces angiogenesis. (PubMed id 11158059)1, 2, 9 Ishikawa H.... Melmed S. (J. Clin. Endocrinol. Metab. 2001)
    10. Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. (PubMed id 19008095)1, 4, 9 Brendle A....FAPrsti A. (Eur. J. Cancer 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9232 HGNC: 9690 AceView: PTTG1 Ensembl:ENSG00000164611 euGenes: HUgn9232
    ECgene: PTTG1 Kegg: 9232 H-InvDB: PTTG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTTG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTTG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTTG1 gene:
    Search GeneIP for patents involving PTTG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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