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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTTG1 Gene

protein-coding   GIFtS: 62
GCID: GC05P159781

Pituitary Tumor-Transforming 1


(Previous symbol: TUTR1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pituitary Tumor-Transforming 11 2     PTTG2 3
TUTR11 2 3 5     HPTTG2
Tumor-Transforming Protein 11 2 3     securin2
EAP12 3 5     Esp1-Associated Protein3
ESP1-Associated Protein 11 2     hPTTG3
Pituitary Tumor-Transforming Gene 1 Protein2 3     

External Ids:    HGNC: 96901   Entrez Gene: 92322   Ensembl: ENSG000001646117   OMIM: 6041475   UniProtKB: O959973   

Export aliases for PTTG1 gene to outside databases

Previous GC identifers: GC05P159967 GC05P160358 GC05P159784 GC05P159829 GC05P154942


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTTG1 Gene:
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid
separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation
of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is
highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its
transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor
expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The
acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a
cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same
protein have been found for this gene. (provided by RefSeq, Sep 2013)

GeneCards Summary for PTTG1 Gene: 
PTTG1 (pituitary tumor-transforming 1) is a protein-coding gene. Diseases associated with PTTG1 include thymic hyperplasia, and nelson syndrome, and among its related super-pathways are Cell cycle and Regulation of APC/C activators between G1/S and early anaphase. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is PTTG2.

UniProtKB/Swiss-Prot: PTTG1_HUMAN, O95997
Function: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA
repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1
function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At
the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its
function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively
regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53
may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in
DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid
separation

Gene Wiki entry for PTTG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTTG1 gene promoter:
         Nkx3-1 v4   Elk-1   PPAR-gamma1   Sp1   Lmo2   PPAR-gamma2   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTTG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTTG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTTG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q35.1

PTTG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTTG1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P159781:  view genomic region     (about GC identifiers)

Start:
159,848,829 bp from pter      End:
159,855,748 bp from pter
Size:
6,920 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTTG1_HUMAN, O95997 (See protein sequence)
Recommended Name: Securin  
Size: 202 amino acids; 22024 Da
Subunit: Interacts with RPS10 and DNAJA1 (By similarity). Interacts with the caspase-like ESPL1, and prevents its
protease activity probably by covering its active site. Interacts with TP53 and blocks its activity probably by
blocking its binding to DNA. Interacts with the Ku 70 kDa subunit of ds-DNA kinase. Interacts with PTTG1IP
Subcellular location: Cytoplasm. Nucleus
Developmental stage: Low level during G1 and S phases. Peaks at M phase. During anaphase, it is degraded

Explore the universe of human proteins at neXtProt for PTTG1: NX_O95997

Explore proteomics data for PTTG1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-165 by CDK1 during mitosis
  • UniProtKB: Phosphorylated in vitro by ds-DNA kinase
  • UniProtKB: Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset
    of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase
    UBE2C/UBCH10
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95997

  • PTTG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTTG1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001269311.1  NP_001269312.1  NP_004210.1  

    ENSEMBL proteins: 
     ENSP00000344936   ENSP00000431068   ENSP00000430642   ENSP00000377536  
    Reactome Protein details: O95997
    Human Recombinant Protein Products for PTTG1: 
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    Novus Biologicals PTTG1 Proteins
    Novus Biologicals PTTG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PTTG1
    Cloud-Clone Corp. Proteins for PTTG1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    PTTG1 for ontologies           About GeneDecksing



    PTTG1 Antibody Products: 
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    Assay Products for PTTG1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR018008 Securin_separation-inh_met
     IPR006940 Securin_separation_inhibitor

    Graphical View of Domain Structure for InterPro Entry O95997

    ProtoNet protein and cluster: O95997

    UniProtKB/Swiss-Prot: PTTG1_HUMAN, O95997
    Domain: The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the
    ubiquitin-proteasome pathway (By similarity)
    Domain: The TEK-boxes are required for 'Lys-11'-linked ubiquitination and facilitate the transfer of the first
    ubiquitin and ubiquitin chain nucleation. TEK-boxes may direct a catalytically competent orientation of the
    UBE2C/UBCH10-ubiquitin thioester with the acceptor lysine residue
    Similarity: Belongs to the securin family


    PTTG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTTG1_HUMAN, O95997
    Function: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA
    repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1
    function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At
    the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its
    function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively
    regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53
    may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in
    DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid
    separation

         Genatlas biochemistry entry for PTTG1:
    rat pituitary tumor transforming 1,overexpressed in Jurkat cells and in several hematopoietic malignancies,mainly
    located in cytosol but partly in nucleus,expressed in normal adult testis,thymus,colon,brain,lung and fetal liver

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9811450
    GO:0004869cysteine-type endopeptidase inhibitor activity NAS12194817
    GO:0005515protein binding IPI12194817
    GO:0017124SH3 domain binding IEA--
         
    PTTG1 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Pttg1):
     adipose tissue  behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     nervous system  no phenotypic analysis  renal/urinary system  reproductive system 

    PTTG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PTTG1: Pttg1tm1.2Kna Pttg1tm1.1Tno Pttg1tm1Pzg Pttg1tm1Sme

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTTG1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTTG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTTG1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTTG1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTTG1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PTTG1:
    hsa-miR-374c hsa-miR-655
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTTG1
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: PTTG1 (NM_004339)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTTG1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTTG1 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins0.93
    APC/C-mediated degradation of cell cycle proteins0.94
    APC/C:Cdc20 mediated degradation of Securin0.93
    Regulation of mitotic cell cycle0.94
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G10.93
    3M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    4Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    5Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation0.98

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for PTTG1
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Spindle assembly and chromosome separation
    Meiosis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTTG1
        Mitotic Roles of Polo Like Kinases

    2 GeneGo (Thomson Reuters) Pathways for PTTG1
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Spindle assembly and chromosome separation

    2 BioSystems Pathways for PTTG1
        Cell cycle
    Integrated Pancreatic Cancer Pathway

    5/13        Reactome Pathways for PTTG1 (see all 13)
        Mitotic Metaphase and Anaphase
    APC/C:Cdc20 mediated degradation of mitotic proteins
    Mitotic Anaphase
    Cell Cycle
    M Phase


    3         Kegg Pathways  (Kegg details for PTTG1):
        Cell cycle
    Oocyte meiosis
    HTLV-I infection


    PTTG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTTG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/79 Interacting proteins for PTTG1 (O959973 ENSP000003449364) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESPL1Q146743, ENSP000002579344I2D: score=4 STRING: ENSP00000257934
    TP53P046373, ENSP000002693054I2D: score=4 STRING: ENSP00000269305
    DNAJA1P316893, ENSP000003691274I2D: score=3 STRING: ENSP00000369127
    PTTG1IPP538013, ENSP000003283254I2D: score=3 STRING: ENSP00000328325
    XRCC6P129563, ENSP000003522574I2D: score=3 STRING: ENSP00000352257
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006259DNA metabolic process ----
    GO:0006281DNA repair IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS9811450
    GO:0006366transcription from RNA polymerase II promoter TAS9811450

    PTTG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTTG1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTTG1

    10/12 Novoseek inferred chemical compound relationships for PTTG1 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ag 1478 31.4 2 16959877 (1), 15178645 (1)
    nocodazole 29 1 17197431 (1)
    vegf 25.9 32 12590639 (7), 12213878 (4), 15649325 (3), 16926250 (2) (see all 8)
    ribonucleic acid 15.5 4 11158059 (1), 12324572 (1), 12970167 (1)
    agar 13.5 3 14709851 (1), 15649325 (1)
    proline 9.38 3 9892021 (2), 15929994 (1)
    estrogen 9.29 15 17222350 (3), 10546001 (2), 18217976 (1), 11805140 (1) (see all 5)
    dopamine 5.07 3 16411064 (1), 18791324 (1)
    calcium 4.95 4 12970167 (2), 17882219 (1)
    phosphatidylinositol 3.66 4 19549593 (1), 15922332 (1), 17107960 (1)

    Search CenterWatch for drugs/clinical trials and news about PTTG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTTG1 gene (3 alternative transcripts): 
    NM_001282382.1  NM_001282383.1  NM_004219.3  

    Unigene Cluster for PTTG1:

    Pituitary tumor-transforming 1
    Hs.350966  [show with all ESTs]
    Unigene Representative Sequence: BE904476
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000352433(uc003lyj.3) ENST00000524244 ENST00000517480 ENST00000523659
    ENST00000520452 ENST00000393964(uc003lyk.3) ENST00000519287
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTTG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTTG1

    Additional mRNA sequence: 

    AF062649.1 AF075242.1 AF095287.1 AJ223953.1 AK312209.1 BC026003.1 BC101834.1 BC108894.1 
    BC108895.1 BC112071.1 BC113842.1 BC113896.1 BC128193.1 BC128194.1 CR457135.1 CR541685.1 

    15 DOTS entries:

    DT.456008  DT.100793413  DT.100793412  DT.102825886  DT.95249453  DT.91937026  DT.99984804  DT.100793410 
    DT.120875033  DT.99983395  DT.120874968  DT.95093366  DT.95093390  DT.99992318  DT.91938081 

    24/301 AceView cDNA sequences (see all 301):

    BM548937 AA436999 CB135968 BM762580 AJ223953 BG034515 AA039876 AA081273 
    BG576154 AA380236 BF797308 T25511 BI827526 AA033896 AI870484 H77519 
    BI256425 AA075247 CA502951 BM461796 AA074947 BM784799 AA430241 CB143123 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTTG1 expression in normal human tissues (normalized intensities)      PTTG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATCCAAT
    PTTG1 Expression
    About this image


    PTTG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Olfactory Bulb   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Mesenchymal Stem Cells
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   
     
     Bone (Muscoskeletal System)
             Human Vertebral Mesenchymal Stem Cells (HVMSC)   
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer

    See PTTG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTTG1

    SOURCE GeneReport for Unigene cluster: Hs.350966

    UniProtKB/Swiss-Prot: PTTG1_HUMAN, O95997
    Tissue specificity: Expressed at low level in most tissues, except in adult testis, where it is highly expressed.
    Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal
    cancer

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PTTG1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pttg11 , 5 pituitary tumor-transforming gene 11, 5 79.4(n)1
    72.86(a)1
      11 (25.68 cM)5
    309391  NM_001131054.11  NP_001124526.11 
     434202505 
    chicken
    (Gallus gallus)
    Aves PTTG11 pituitary tumor-transforming 1 60.43(n)
    49.2(a)
      416158  XM_414490.2  XP_414490.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    37(a)
    1 → many
    GL343286.1(1238598-1251011)
    zebrafish
    (Danio rerio)
    Actinopterygii CU151895.16
    pttg16
    pituitary tumor-transforming 1
    31(a)
    31(a)
    many ↔ many
    many ↔ many
    14(43491368-43494305)
    14(35688889-35691689)


    ENSEMBL Gene Tree for PTTG1 (if available)
    TreeFam Gene Tree for PTTG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTTG1 gene
    PTTG22  
    3 SIMAP similar genes for PTTG1 using alignment to 5 protein entries:     PTTG1_HUMAN (see all proteins):
    PTTG    PTTG2    PTTG3P

    PTTG1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for PTTG1
    PGOHUM00000242319 PGOHUM00000232606 PGOHUM00000257190


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/170 SNPs in PTTG1 are shown (see all 170)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1807976001,2
    --159848186(+) GTTAAC/TATATT 1 -- us2k10--------
    rs18623921,2
    C--159848193(-) TCTCAA/TTAATA 1 -- us2k1 tfbs34Minor allele frequency- T:0.18NA WA EA 360
    rs120547731,2
    C,F,H--159848287(+) TGTTCC/TTAAGA 1 -- us2k16Minor allele frequency- T:0.01NS NA 900
    rs1489497951,2
    C--159848317(+) TAGAA-/ACAGTGT 1 -- us2k10--------
    rs1850624751,2
    C--159848375(+) GTTCGC/TTCTTA 1 -- us2k10--------
    rs18623911,2
    C,F,H--159848467(-) AATACT/GAGCAG 1 -- us2k116Minor allele frequency- G:0.18NS EA NA WA 2336
    rs1894543371,2
    --159848913(+) TGGGAA/GGGTCG 1 -- int10--------
    rs1382218561,2
    C--159848977(+) CTGGG-/GCTGAA
            
    GCTGA
    1 -- cds10--------
    rs1398114881,2
    --159849053(+) TCGGAC/TTGCTA 1 -- int10--------
    rs1816076441,2
    --159849176(+) TGGCTC/TACGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for PTTG1 (159848829 - 159855748 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PTTG1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883072CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604147    OMIM disorders: --

    20/55 diseases for PTTG1 (see all 55):    About MalaCards
    thymic hyperplasia    nelson syndrome    pituitary tumors    prolactinoma
    thyroid cancer    cutaneous malignant melanoma    craniopharyngioma    gigantism
    pituitary adenoma    squamous cell carcinoma of the head and neck    testicular cancer    human t-cell leukemia virus type 1
    esophageal squamous cell carcinoma    choriocarcinoma    non-small cell lung carcinoma    esophageal cancer
    thrombocytopenia    ataxia telangiectasia    scleroderma    astrocytoma

    2 diseases from the University of Copenhagen DISEASES database for PTTG1:
    Cancer     Adenoma

    PTTG1 for disorders           About GeneDecksing

    10/34 Novoseek inferred disease relationships for PTTG1 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary tumors 90.2 128 17652795 (4), 10022450 (4), 14709851 (3), 11805140 (3) (see all 60)
    pituitary adenoma 78.9 60 16984249 (5), 20106827 (4), 12580929 (4), 12580928 (3) (see all 23)
    prolactinoma 58.9 9 17222350 (3), 16411064 (1), 10546001 (1), 12554778 (1) (see all 6)
    thyroid cancer 55.1 11 12727994 (2), 16759264 (2), 15897900 (2), 16926250 (1) (see all 8)
    follicular thyroid cancer 54.3 1 17127711 (1)
    adenoma 53.2 15 16447816 (3), 12580928 (2), 20106827 (2), 12590639 (2) (see all 8)
    tumors 47.8 188 17096843 (6), 10393434 (5), 15649325 (5), 17029632 (5) (see all 64)
    aggressiveness 44.2 6 17306208 (1), 16418208 (1), 18791324 (1), 14759723 (1) (see all 5)
    macroprolactinoma 43.6 1 17222350 (1)
    cancer 43.1 40 20457353 (3), 10084610 (2), 16809406 (2), 16219911 (2) (see all 20)

    Genetic Association Database (GAD): PTTG1
    Human Genome Epidemiology (HuGE) Navigator: PTTG1 (9 documents)

    Export disorders for PTTG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTTG1 gene, integrated from 9 sources (see all 309):
    (articles sorted by number of sources associating them with PTTG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). (PubMed id 9892021)1, 2, 3, 9 Zhang X....Melmed S. (1999)
    2. hPTTG, a human homologue of rat PTTG, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. (PubMed id 9811450)1, 2, 3 Dominguez A.... Pintor-Toro J.A. (1998)
    3. Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis. (PubMed id 12355087)1, 2, 9 Bernal J.A.... Pintor-Toro J.A. (2002)
    4. Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. (PubMed id 10022450)1, 2, 9 Zhang X.... Melmed S. (1999)
    5. Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG). (PubMed id 10580151)1, 2, 9 Kakar S.S. (1999)
    6. Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase. (PubMed id 11238996)1, 2, 9 Romero F.... Tortolero M. (2001)
    7. A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor- transforming gene product. (PubMed id 10781616)1, 2, 9 Chien W. and Pei L. (2000)
    8. Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis. (PubMed id 10393434)1, 2, 9 Kakar S.S. and Jennes L. (1999)
    9. Human pituitary tumor-transforming gene induces angiogenesis. (PubMed id 11158059)1, 2, 9 Ishikawa H.... Melmed S. (2001)
    10. Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: A Swedish prospective case-control study. (PubMed id 19008095)1, 4, 9 Brendle A....Forsti A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9232 HGNC: 9690 AceView: PTTG1 Ensembl:ENSG00000164611 euGenes: HUgn9232
    ECgene: PTTG1 Kegg: 9232 H-InvDB: PTTG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTTG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTTG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTTG1 gene:
    Search GeneIP for patents involving PTTG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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