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Aliases for PTPRZ1 Gene

Aliases for PTPRZ1 Gene

  • Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 2 3
  • Protein-Tyrosine Phosphatase Receptor Type Z Polypeptide 2 3 4
  • R-PTP-Zeta-2 3 4
  • EC 3.1.3.48 4 64
  • PTPRZ 3 4
  • PTP18 3 6
  • PTPZ 3 4
  • Protein Tyrosine Phosphatase, Receptor-Type, Zeta Polypeptide 1 3
  • Protein-Tyrosine Phosphatase Receptor Type Z Polypeptide 1 4
  • Receptor-Type Tyrosine-Protein Phosphatase Zeta 3
  • Receptor-Type Tyrosine Phosphatase Beta/Zeta 3
  • Phosphacan 3
  • R-PTP-Zeta 4
  • HPTPzeta 3
  • PTP-ZETA 3
  • RPTPbeta 3
  • HTPZP2 4
  • PTPRZ2 4
  • HPTPZ 3
  • RPTPB 3

External Ids for PTPRZ1 Gene

Previous Symbols for PTPRZ1 Gene

  • PTPZ
  • PTPRZ

Summaries for PTPRZ1 Gene

Entrez Gene Summary for PTPRZ1 Gene

  • This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for PTPRZ1 Gene

PTPRZ1 (Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1) is a Protein Coding gene. Diseases associated with PTPRZ1 include h. pylori infection. Among its related pathways are PAK Pathway and Spinal Cord Injury. GO annotations related to this gene include transmembrane receptor protein tyrosine phosphatase activity and protein tyrosine/threonine phosphatase activity. An important paralog of this gene is PTPRT.

UniProtKB/Swiss-Prot for PTPRZ1 Gene

  • Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).

Gene Wiki entry for PTPRZ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRZ1 Gene

Genomics for PTPRZ1 Gene

Genomic Location for PTPRZ1 Gene

Start:
121,873,089 bp from pter
End:
122,062,036 bp from pter
Size:
188,948 bases
Orientation:
Plus strand

Genomic View for PTPRZ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRZ1 Gene

Regulatory Elements for PTPRZ1 Gene

Proteins for PTPRZ1 Gene

  • Protein details for PTPRZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23471-PTPRZ_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase zeta
    Protein Accession:
    P23471
    Secondary Accessions:
    • A4D0W5
    • C9JFM0
    • O76043
    • Q9UDR6

    Protein attributes for PTPRZ1 Gene

    Size:
    2315 amino acids
    Molecular mass:
    254587 Da
    Quaternary structure:
    • The carbonic-anhydrase like domain interacts with CNTN1 (contactin).
    SequenceCaution:
    • Sequence=AAC39934.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus may be contaminated with vector sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRZ1 Gene

    Alternative splice isoforms for PTPRZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRZ1 Gene

Proteomics data for PTPRZ1 Gene at MOPED

Post-translational modifications for PTPRZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn105, Asn134, Asn223, Asn232, Asn324, Asn381, Thr479, Ser482, Thr484, Asn497, Asn501, Asn552, Ser587, Ser600, Asn602, Ser604, Asn629, Ser637, Asn677, Ser686, Thr689, Thr690, Thr721, Thr724, Ser997, Asn1017, Asn1050, Asn1082, Asn1122, Thr1338, Ser1339, Thr1340, Ser1396, Asn1457, Ser1549, Ser1551, Asn1562, and Asn1618

Other Protein References for PTPRZ1 Gene

Domains for PTPRZ1 Gene

Gene Families for PTPRZ1 Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • PTPR :Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like
IUPHAR :

UniProtKB/Swiss-Prot:

PTPRZ_HUMAN
Domain:
  • Contains 1 alpha-carbonic anhydrase domain.:
    • P23471
  • Contains 1 fibronectin type-III domain.:
    • P23471
  • Contains 2 tyrosine-protein phosphatase domains.:
    • P23471
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.:
    • P23471
genes like me logo Genes that share domains with PTPRZ1: view

Function for PTPRZ1 Gene

Molecular function for PTPRZ1 Gene

GENATLAS Biochemistry: protein tyrosine phosphatase,receptor-type,zeta polypeptide
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).

Enzyme Numbers (IUBMB) for PTPRZ1 Gene

Gene Ontology (GO) - Molecular Function for PTPRZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity ISS --
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 1323835
GO:0005515 protein binding IPI 17681947
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPRZ1: view
genes like me logo Genes that share phenotypes with PTPRZ1: view

Animal Models for PTPRZ1 Gene

MGI Knock Outs for PTPRZ1:

miRNA for PTPRZ1 Gene

miRTarBase miRNAs that target PTPRZ1

No data available for Transcription Factor Targeting and HOMER Transcription for PTPRZ1 Gene

Localization for PTPRZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRZ1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is apparently generated by shedding of the extracellular domain. {ECO:0000250}.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRZ1 Gene COMPARTMENTS Subcellular localization image for PTPRZ1 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005887 integral component of plasma membrane TAS 8387522
GO:0072534 perineuronal net IEA --
genes like me logo Genes that share ontologies with PTPRZ1: view

Pathways for PTPRZ1 Gene

genes like me logo Genes that share pathways with PTPRZ1: view

Pathways by source for PTPRZ1 Gene

1 Qiagen pathway for PTPRZ1 Gene
1 BioSystems pathway for PTPRZ1 Gene

Gene Ontology (GO) - Biological Process for PTPRZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006470 protein dephosphorylation TAS 1323835
GO:0007409 axonogenesis IEA --
GO:0007417 central nervous system development TAS 8387522
GO:0007611 learning or memory ISS --
genes like me logo Genes that share ontologies with PTPRZ1: view

Compounds for PTPRZ1 Gene

(2) HMDB Compounds for PTPRZ1 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(1) Novoseek inferred chemical compound relationships for PTPRZ1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 60.6 23
genes like me logo Genes that share compounds with PTPRZ1: view

Transcripts for PTPRZ1 Gene

Unigene Clusters for PTPRZ1 Gene

Protein tyrosine phosphatase, receptor-type, Z polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRZ1 Gene

No ASD Table

Relevant External Links for PTPRZ1 Gene

GeneLoc Exon Structure for
PTPRZ1
ECgene alternative splicing isoforms for
PTPRZ1

Expression for PTPRZ1 Gene

mRNA expression in normal human tissues for PTPRZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRZ1 Gene

This gene is overexpressed in Brain - Amygdala (6.7), Brain - Nucleus accumbens (basal ganglia) (5.2), Brain - Caudate (basal ganglia) (5.0), Brain - Hippocampus (4.3), Brain - Putamen (basal ganglia) (4.3), and Brain - Anterior cingulate cortex (BA24) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTPRZ1 Gene

SOURCE GeneReport for Unigene cluster for PTPRZ1 Gene Hs.489824

mRNA Expression by UniProt/SwissProt for PTPRZ1 Gene

P23471-PTPRZ_HUMAN
Tissue specificity: Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.
genes like me logo Genes that share expressions with PTPRZ1: view

Orthologs for PTPRZ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRZ1 36
  • 99.55 (n)
  • 99.44 (a)
PTPRZ1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRZ1 36
  • 88.63 (n)
  • 85.58 (a)
PTPRZ1 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRZ1 37
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprz1 36
  • 85.48 (n)
  • 82.65 (a)
Ptprz1 16
Ptprz1 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPRZ1 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRZ1 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprz1 36
  • 85.4 (n)
  • 82.42 (a)
chicken
(Gallus gallus)
Aves PTPRZ1 36
  • 77.06 (n)
  • 76.76 (a)
PTPRZ1 37
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRZ1 37
  • 33 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1099 36
zebrafish
(Danio rerio)
Actinopterygii ca16c 36
  • 63.74 (n)
  • 63.98 (a)
ptprz1a 37
  • 40 (a)
OneToMany
ptprz1b 37
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ptp99A 37
  • 27 (a)
OneToMany
Ptp99A 38
  • 43 (a)
Ptp52F 38
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK616.7 38
  • 36 (a)
F47B3.6 38
  • 28 (a)
K07F5.8 38
  • 34 (a)
F36H12.10 38
  • 36 (a)
C55B7.3 38
  • 36 (a)
F47B3.1 38
  • 28 (a)
F10G8.1 38
  • 34 (a)
M04G7.2 38
  • 37 (a)
K04D7.4 38
  • 30 (a)
ZK484.7 38
  • 34 (a)
C17H12.3 38
  • 33 (a)
C02B10.6 38
  • 36 (a)
F47B3.7 38
  • 34 (a)
Species with no ortholog for PTPRZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPRZ1 Gene

ENSEMBL:
Gene Tree for PTPRZ1 (if available)
TreeFam:
Gene Tree for PTPRZ1 (if available)

Paralogs for PTPRZ1 Gene

Paralogs for PTPRZ1 Gene

genes like me logo Genes that share paralogs with PTPRZ1: view

Variants for PTPRZ1 Gene

Sequence variations from dbSNP and Humsavar for PTPRZ1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs727766 -- 121,917,987(+) ATTAT(C/G)AATTT intron-variant
rs727767 -- 121,918,005(+) TAAAT(A/G)TGCTT intron-variant
rs727768 -- 121,918,054(+) AAAAA(A/C)AAAAA intron-variant
rs740960 -- 121,886,324(-) AAAGA(A/C)CCTGT intron-variant
rs740964 -- 121,872,895(+) GAACA(C/T)TGGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PTPRZ1 Gene

Variant ID Type Subtype PubMed ID
esv2516212 CNV Deletion 19546169
nsv365800 CNV Loss 16902084
esv2735088 CNV Deletion 23290073
esv2659008 CNV Deletion 23128226

Relevant External Links for PTPRZ1 Gene

HapMap Linkage Disequilibrium report
PTPRZ1

Disorders for PTPRZ1 Gene

(1) OMIM Diseases for PTPRZ1 Gene (176891)

(1) MalaCards Diseases for PTPRZ1 Gene

Search for PTPRZ1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PTPRZ1 Gene

(4) Novoseek inferred disease relationships for PTPRZ1 Gene

Disease -log(P) Hits PubMed IDs
glioblastoma 65.1 4
glioma 46.7 2
astrocytoma 36 1
tumors 9.58 1

Relevant External Links for PTPRZ1

Genetic Association Database (GAD)
PTPRZ1
Human Genome Epidemiology (HuGE) Navigator
PTPRZ1
genes like me logo Genes that share disorders with PTPRZ1: view

No data available for UniProtKB/Swiss-Prot for PTPRZ1 Gene

Publications for PTPRZ1 Gene

  1. No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population. (PMID: 15998549) Marui T. … Sasaki T. (Neurosci. Res. 2005) 3 23 49
  2. No association between the protein tyrosine phosphatase, receptor-type, Z Polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population. (PMID: 18186075) Ito Y. … Ozaki N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23 49
  3. The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. (PMID: 8387522) Levy J.B. … Schlessinger J. (J. Biol. Chem. 1993) 2 3 4
  4. Characterization of the activation of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) by hypoxia inducible factor-2 alpha. (PMID: 20224786) Wang V. … Yarchoan R. (PLoS ONE 2010) 3 23
  5. A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. (PMID: 1323835) Krueger N.X. … Saito H. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4

Products for PTPRZ1 Gene

Sources for PTPRZ1 Gene

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