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PTPRZ1 Gene

protein-coding   GIFtS: 67
GCID: GC07P121513

Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide...


(Previous symbols: PTPZ, PTPRZ)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 11 2     RPTPB2
PTPRZ1 2 3     RPTPbeta2
PTPZ1 2 3     phosphacan2
Protein-Tyrosine Phosphatase Receptor Type Z Polypeptide 22 3     Protein Tyrosine Phosphatase, Receptor-Type, Zeta Polypeptide 12
R-PTP-zeta-22 3     Receptor-Type Tyrosine Phosphatase Beta/Zeta2
EC 3.1.3.483 8     Receptor-Type Tyrosine-Protein Phosphatase Zeta2
PTP182 5     HTPZP23
HPTPZ2     PTPRZ23
HPTPzeta2     R-PTP-zeta3
PTP-ZETA2     Protein-Tyrosine Phosphatase Receptor Type Z Polypeptide 13

External Ids:    HGNC: 96851   Entrez Gene: 58032   Ensembl: ENSG000001062787   OMIM: 1768915   UniProtKB: P234713   

Export aliases for PTPRZ1 gene to outside databases

Previous GC identifers: GC07P119991 GC07P121053 GC07P121068 GC07P121069 GC07P121108 GC07P121301 GC07P115876


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPRZ1 Gene:
This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is
restricted to the central nervous system (CNS), and it may be involved in the regulation of specific
developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have
been described for this gene. (provided by RefSeq, May 2011)

GeneCards Summary for PTPRZ1 Gene:
PTPRZ1 (protein tyrosine phosphatase, receptor-type, Z polypeptide 1) is a protein-coding gene. Diseases associated with PTPRZ1 include h. pylori infection, and hyperkalemic periodic paralysis. GO annotations related to this gene include protein tyrosine/threonine phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRK.

UniProtKB/Swiss-Prot: PTPRZ_HUMAN, P23471
Function: Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the
embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating
oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the
establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important
signaling cascades (By similarity)

Gene Wiki entry for PTPRZ1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPRZ1 gene promoter:
         GR   HOXA3   POU6F1 (c2)   CUTL1   Tal-1beta   C/EBPalpha   E47   Cart-1   IRF-7A   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): PTPRZ1 promoter sequence
   Search Chromatin IP Primers for PTPRZ1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPRZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q31.32   HGNC cytogenetic band: 7q31.3

PTPRZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRZ1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P121513:  view genomic region     (about GC identifiers)

Start:
121,513,143 bp from pter      End:
121,702,090 bp from pter
Size:
188,948 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 120,907,807-121,096,757     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PTPRZ_HUMAN, P23471 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein phosphatase zeta precursor  
Size: 2315 amino acids; 254587 Da
Subunit: The carbonic-anhydrase like domain interacts with CNTN1 (contactin)
Caution: Was termed (PubMed:8387522 and PubMed:2170109) RPTPase beta
Caution: The human genome was initially thought to contain 2 genes for PTPRZ: PTPRZ1 (on chr 7) and PTPRZ2 (on chr
1). However, PTPRZ2 probably does not exist and corresponds to PTPRZ1
Sequence caution: Sequence=AAC39934.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus
may be contaminated with vector sequence;
2 PDB 3D structures from and Proteopedia for PTPRZ1:
3JXF (3D)        3S97 (3D)    
Secondary accessions: A4D0W5 O76043 Q9UDR6
Alternative splicing: 2 isoforms:  P23471-1   P23471-2   

Explore the universe of human proteins at neXtProt for PTPRZ1: NX_P23471

Explore proteomics data for PTPRZ1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn105, Asn134, Asn223, Asn232, Asn324, Asn381, Thr479, Ser482, Thr484, Asn497,
                                 Asn501, Asn552, Ser587, Ser600, Asn602, Ser604, Asn629, Ser637, Asn677, Ser686 (see all 38)
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTPRZ1 (P23471) (see all 15)
     VQTEEQY  VVHCSAG  KCDQYWP  GFLKHIR 


    See PTPRZ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193767.1  NP_001193768.1  NP_002842.2  

    ENSEMBL proteins: 
     ENSP00000377047   ENSP00000410000  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    PTPR: Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like

    IUPHAR Guide to PHARMACOLOGY protein family classification: Type Z1
    Receptor tyrosine phosphatases (RTP)

    Selected InterPro protein domains (see all 6):
     IPR003961 Fibronectin_type3
     IPR001148 Carbonic_anhydrase_a
     IPR016130 Tyr_Pase_AS
     IPR013783 Ig-like_fold
     IPR000242 Tyr_Pase_rcpt/non-rcpt

    Graphical View of Domain Structure for InterPro Entry P23471

    ProtoNet protein and cluster: P23471

    2 Blocks protein domains:
    IPB000242 Protein tyrosine phosphatase signature
    IPB001148 Carbonic anhydrase


    UniProtKB/Swiss-Prot: PTPRZ_HUMAN, P23471
    Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily
    Similarity: Contains 1 alpha-carbonic anhydrase domain
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 2 tyrosine-protein phosphatase domains


    PTPRZ1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTPRZ_HUMAN, P23471
    Function: Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the
    embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating
    oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the
    establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important
    signaling cascades (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPRZ1:
    protein tyrosine phosphatase,receptor-type,zeta polypeptide

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ISS--
    GO:0005001transmembrane receptor protein tyrosine phosphatase activity TAS1323835
    GO:0005515protein binding IPI17681947
    GO:0016791phosphatase activity ----
         
    PTPRZ1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PTPRZ1:
     Decreased cell number and incr  Increased apoptosis 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ptprz1):
     behavior/neurological  immune system  integument  nervous system  normal 

    PTPRZ1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptprz1tm1Schl for PTPRZ1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTPRZ1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPRZ1

    miRNA
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    miRTarBase miRNAs that target PTPRZ1:
    hsa-mir-181a-5p (MIRT025060), hsa-mir-124-3p (MIRT022444)

    Block miRNA regulation of human, mouse, rat PTPRZ1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPRZ1 (see all 14):
    hsa-miR-3163 hsa-miR-569 hsa-miR-187* hsa-miR-1283 hsa-miR-513a-3p hsa-miR-1261 hsa-miR-708* hsa-miR-133b
    SwitchGear 3'UTR luciferase reporter plasmidPTPRZ1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PTPRZ1
    Predesigned siRNA for gene silencing in human, mouse, rat PTPRZ1

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRZ1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTPRZ_HUMAN, P23471: Isoform Long: Cell membrane; Single-pass type I membrane protein. Secreted (By similarity).
    Note=A secreted form is apparently generated by shedding of the extracellular domain (By similarity)
    PTPRZ_HUMAN, P23471: Isoform Short: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytoskeleton1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005887integral component of plasma membrane TAS8387522
    GO:0072534perineuronal net IEA--

    PTPRZ1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPRZ1 About    
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2Insulin receptor recycling
    Epithelial cell signaling in Helicobacter pylori infection0.32
    3Spinal Cord Injury
    Spinal Cord Injury

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPRZ1
        Epithelial Adherens Junctions

    1 BioSystems Pathway for PTPRZ1
        Spinal Cord Injury


    1 Kegg Pathway  (Kegg details for PTPRZ1):
        Epithelial cell signaling in Helicobacter pylori infection


    PTPRZ1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PTPRZ1: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPRZ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTPRZ1 (P234711, 2, 3 ENSP000003770474) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALKQ9UM731, 2, 3, ENSP000003737004EBI-2263175,EBI-357361 MINT-8238486 MINT-8238512 I2D: score=2 STRING: ENSP00000373700
    TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS1323835
    GO:0007409axonogenesis IEA--
    GO:0007417central nervous system development TAS8387522
    GO:0007611learning or memory ISS--
    GO:0016311dephosphorylation ----

    PTPRZ1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPRZ1 (PTPRZ)

    2 HMDB Compounds for PTPRZ1    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 Novoseek inferred chemical compound relationship for PTPRZ1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 60.6 26 18186075 (2), 19356122 (2), 12573468 (2), 15161428 (2) (see all 18)



    PTPRZ1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PTPRZ1 gene (3 alternative transcripts): 
    NM_001206838.1  NM_001206839.1  NM_002851.2  

    Unigene Cluster for PTPRZ1:

    Protein tyrosine phosphatase, receptor-type, Z polypeptide 1
    Hs.489824  [show with all ESTs]
    Unigene Representative Sequence: NM_002851
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393386(uc003vjy.3 uc011knt.2 uc003vjz.3) ENST00000471837
    ENST00000449182 ENST00000483028 ENST00000489114 ENST00000483995 ENST00000468641
    ENST00000470504 ENST00000474500
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    hsa-miR-3163 hsa-miR-569 hsa-miR-187* hsa-miR-1283 hsa-miR-513a-3p hsa-miR-1261 hsa-miR-708* hsa-miR-133b
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      QuantiFast Probe-based Assays in human, mouse, rat PTPRZ1

    Additional mRNA sequence: 

    AK294062.1 BC131736.1 M93426.1 U88967.1 X54135.1 

    14 DOTS entries:

    DT.215012  DT.100658512  DT.97845891  DT.40116727  DT.95279451  DT.121099207  DT.91745483  DT.100658513 
    DT.91788881  DT.100707116  DT.100717441  DT.86857066  DT.102823262  DT.95080344 

    Selected AceView cDNA sequences (see all 159):

    BM728701 AL157677 AU124826 NM_002851 AV726123 BM710662 BF197661 AU124025 
    BF223256 BI488535 BM927037 AI090956 AI076051 AW054767 CD643078 BM722914 
    AI359879 X54135 F02235 AI633894 AU133054 AV721223 M93426 AL600093 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPRZ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTTTAAC
    PTPRZ1 Expression
    About this image


    PTPRZ1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Cerebellum
             Oligodendrocyte-like cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 7 entries
             Human embryonic stem cells (family)
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced cells
    PTPRZ1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPRZ1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.489824

    UniProtKB/Swiss-Prot: PTPRZ_HUMAN, P23471
    Tissue specificity: Specifically expressed in the central nervous system, where it is localized in the Purkinje
    cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral
    ventricle. Developmentally regulated in the brain

        Pathway & Disease-focused RT2 Profiler PCR Array including PTPRZ1: 
              Protein Phosphatases in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat PTPRZ1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRZ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTPRZ1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptprz11 , 5 protein tyrosine phosphatase, receptor type Z, polypeptide more1, 5 85.48(n)1
    82.65(a)1
      6 (9.92 cM)5
    192831  NM_001081306.11  NP_001074775.11 
     228755025 
    chicken
    (Gallus gallus)
    Aves PTPRZ11 protein tyrosine phosphatase, receptor-type, Z polypeptide more 77.06(n)
    76.76(a)
      396403  NM_001199312.1  NP_001186241.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTPRZ16
    protein tyrosine phosphatase, receptor-type, Z pol...
    33(a)
    1 ↔ 1
    GL343585.1(197313-223844)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.10992 Xenopus laevis XRPTPb mRNA for receptor-type protein more 78.7(n)    AB045237.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ca16c1 carbonic anhydrase XVI c 63.74(n)
    63.98(a)
      497461  XM_005163137.1  XP_005163194.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ptp99A3 defasciculation of motor neuron
    transmembrane more
    43(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for PTPRZ1 (if available)
    TreeFam Gene Tree for PTPRZ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPRZ1 gene
    PTPRK2  PTPRC2  PTPRA2  PTPRG2  PTPRD2  PTPRS2  PTPRU2  PTPRM2  
    PTPRF2  PTPRT2  PTPRE2  
    Selected SIMAP similar genes for PTPRZ1 using alignment to 2 protein entries:     PTPRZ_HUMAN (see all proteins) (see all similar genes):
    DKFZp313F1310    DKFZp781C1038    PTPRG    CA12    PTPRS    CA6
    PTPN5    PTPN7    DKFZp761A0712    DKFZp566K0524    PTPRE    PTPRR
    DKFZp686K0257    PTPN20A    PTPN20B    BPTP-3    PTPRA    PTN2

    PTPRZ1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPRZ1 (see all 3411)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58870581,2
    C--115901197(+) TTTTTT/-CATGT 3 -- int1 trp31Minor allele frequency- -:0.00CSA 2
    rs343130861,2
    C--115951749(+) TTTTT-/TTTTTT 3 -- int10--------
    rs96494461,2
    C,A--115971727(+) TTTTTT/AAAAAA 3 -- int1 trp31Minor allele frequency- A:0.50WA 2
    rs2004745281,2
    C--116061147(+) TGATTC/TTTTTT 3 -- int10--------
    rs2012931631,2
    C--120908866(-) TTTTTG/TTAAGT 3 -- int10--------
    rs597019281,2
    C--120951009(+) AAAAA-/A/AA  
            
    GTTCA
    3 -- int11NA 2
    rs767863451,2
    C--121000829(+) AACTT-/ACT   
      T
    /CTTA
    CTTCA
    3 -- int11CSA 2
    rs342082591,2
    C--121015852(+) CAAAAA/-AAAAA 3 -- int11Minor allele frequency- -:0.00NA 2
    rs1445370811,2
    C--121027450(+) AGACA-/CTAT  
            
    CTTCT
    3 -- int10--------
    rs677176381,2
    C--121055554(+) TTTTT-/CTTTTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for PTPRZ1 (121513143 - 121702090 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PTPRZ1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2516212CNV Deletion19546169
    esv2735088CNV Deletion23290073
    esv2659008CNV Deletion23128226
    nsv365800CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176891   
    OMIM disorders: 600263  
    18 diseases for PTPRZ1:    
    About MalaCards
    h. pylori infection    hyperkalemic periodic paralysis    spinal cord injury    fibrous histiocytoma
    histiocytoma    oligodendroglioma    astrocytoma    parkinson's disease
    hypoxia    schizophrenia    sarcoma    endotheliitis
    squamous cell carcinoma    prostate cancer    prostatitis    neuronitis
    breast cancer    cerebritis

    1 disease from the University of Copenhagen DISEASES database for PTPRZ1:
    Hyperkalemic periodic paralysis

    PTPRZ1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PTPRZ1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 65.1 4 15908427 (1), 15161428 (1), 20224786 (1), 16941076 (1)
    glioma 46.7 2 14555979 (1), 16941076 (1)
    astrocytoma 36 1 14692702 (1)
    tumors 9.58 1 20224786 (1)

    Genetic Association Database (GAD): PTPRZ1
    Human Genome Epidemiology (HuGE) Navigator: PTPRZ1 (4 documents)

    Export disorders for PTPRZ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPRZ1 gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with PTPRZ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. (PubMed id 8387522)1, 2, 3 Levy J.B.... Schlessinger J. (J. Biol. Chem. 1993)
    2. No association between the protein tyrosine phosphatase, receptor-type, Z Polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population. (PubMed id 18186075)1, 4, 9 Ito Y....Ozaki N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    3. No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population. (PubMed id 15998549)1, 4, 9 Marui T....Sasaki T. (Neurosci. Res. 2005)
    4. The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. (PubMed id 20133774)1, 2 Bouyain S. and Watkins D.J. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    6. Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene. (PubMed id 17579610)1, 4 Buxbaum J.D....O'Donovan M.C. (Mol. Psychiatry 2008)
    7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    9. Molecular cloning and expression analysis of five novel genes in chromosome 1p36. (PubMed id 9653645)1, 2 Onyango P.... Weith A. (Genomics 1998)
    10. Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3. (PubMed id 7736789)1, 3 Ariyama T....Yakura H. (Cytogenet. Cell Genet. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5803 HGNC: 9685 AceView: PTPRZ1 Ensembl:ENSG00000106278 euGenes: HUgn5803
    ECgene: PTPRZ1 Kegg: 5803 H-InvDB: PTPRZ1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPRZ1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPRZ1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PTPRZ1 gene:
    Search GeneIP for patents involving PTPRZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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