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PTPRU Gene

protein-coding   GIFtS: 66
GCID: GC01P029569

Protein Tyrosine Phosphatase, Receptor Type, U

  Search for PTPRU
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Receptor Type, U1 2     hPTP-J2 3
Pi R-PTP-Psi1 2     PTP Pi2 3
Pancreatic Carcinoma Phosphatase 22 3     EC 3.1.3.483 8
Protein-Tyrosine Phosphatase J2 3     PTPU22 5
Protein-Tyrosine Phosphatase Pi2 3     PTP2
Protein-Tyrosine Phosphatase Receptor Omicron2 3     PTP-PI2
Receptor-Type Protein-Tyrosine Phosphatase Psi2 3     PTPPSI2
FMI2 3     R-PTP-PSI2
PCP-22 3     Receptor Protein Tyrosine Phosphatase HPTP-J2
PTP-J2 3     Receptor-Type Tyrosine-Protein Phosphatase U2
PTP-RO2 3     PCP23
PTPRO2 3     R-PTP-psi3
R-PTP-U2 3     GLEPP15

External Ids:    HGNC: 96831   Entrez Gene: 100762   Ensembl: ENSG000000606567   OMIM: 6024545   UniProtKB: Q927293   

Export aliases for PTPRU gene to outside databases

Previous GC identifers: GC01P028728 GC01P029068 GC01P029250 GC01P029383 GC01P027814


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPRU Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane
region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The
extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like
repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in
mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be
regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively
spliced transcript variants have been reported. (provided by RefSeq, Aug 2010)

GeneCards Summary for PTPRU Gene:
PTPRU (protein tyrosine phosphatase, receptor type, U) is a protein-coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRK.

UniProtKB/Swiss-Prot: PTPRU_HUMAN, Q92729
Function: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell
adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of
epithelial integrity. May play a role in megakaryocytopoiesis

Gene Wiki entry for PTPRU Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPRU gene promoter:
         PPAR-gamma1   NF-1   AML1a   HSF2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPRU promoter sequence
   Search Chromatin IP Primers for PTPRU

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPRU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

PTPRU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRU gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P029569:  view genomic region     (about GC identifiers)

Start:
29,563,028 bp from pter      End:
29,653,325 bp from pter
Size:
90,298 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PTPRU_HUMAN, Q92729 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein phosphatase U precursor  
Size: 1446 amino acids; 162423 Da
Subunit: Forms homooligomeric complexes which mediate cell homotypic adhesion (Probable). Interacts (via the
cytoplasmic juxtamembrane domain) with CTNNB1; may mediate interaction with the cadherin/catenin adhesion
complex. Interacts with KIT. May interact with AP3B1
Developmental stage: Expressed in fetal brain, lung and kidney
Sequence caution: Sequence=CAA65016.1; Type=Miscellaneous discrepancy; Note=Several sequencing problems;
Sequence=CAA65832.1; Type=Miscellaneous discrepancy; Note=Several sequencing problems;
Secondary accessions: A6H8L1 O00197 P78399 Q59HA4 Q5SYU4 Q5SYU5 Q92735 Q92850
Alternative splicing: 4 isoforms:  Q92729-1   Q92729-2   Q92729-3   Q92729-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPRU: NX_Q92729

Explore proteomics data for PTPRU at MOPED

Post-translational modifications: 

  • The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain
    (By similarity). Beside the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are
    observed1
  • N-glycosylated1
  • Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic
    product is not phosphorylated1
  • Glycosylation2 at Asn75, Asn410, Asn685
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTPRU (Q92729) (see all 28)
     NYINAAL  PFTVGDN  PIAPPQL  LHPGTTY 


    See PTPRU Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001181930.1  NP_005695.3  NP_573438.3  NP_573439.2  

    ENSEMBL proteins: 
     ENSP00000334941   ENSP00000362884   ENSP00000392332   ENSP00000432906   ENSP00000349333  
     ENSP00000314987  
    Reactome Protein details: Q92729

    PTPRU Human Recombinant Protein Products:

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    Abcam antibodies for PTPRU
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    LSBio Antibodies in human, mouse, rat for PTPRU

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    PTPR: Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like

    IUPHAR Guide to PHARMACOLOGY protein family classification: Type U
    Receptor tyrosine phosphatases (RTP)

    Selected InterPro protein domains (see all 8):
     IPR003961 Fibronectin_type3
     IPR016130 Tyr_Pase_AS
     IPR013783 Ig-like_fold
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry Q92729

    ProtoNet protein and cluster: Q92729

    4 Blocks protein domains:
    IPB000242 Protein tyrosine phosphatase signature
    IPB000998 MAM domain signature
    IPB003599 Immunoglobulin subtype
    IPB003962 Fibronectin type III repeat signature


    UniProtKB/Swiss-Prot: PTPRU_HUMAN, Q92729
    Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily
    Similarity: Contains 4 fibronectin type-III domains
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 MAM domain
    Similarity: Contains 2 tyrosine-protein phosphatase domains


    Find genes that share domains with PTPRU           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTPRU_HUMAN, Q92729
    Function: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell
    adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of
    epithelial integrity. May play a role in megakaryocytopoiesis
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Induction: Up-regulated upon cell contact (at protein level). Down-regulated by phorbol ester (at protein level)
    and calcium ionophore but up-regulated by phorbol ester in megakaryocytic cells (PubMed:10397721)

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IMP16574648
    GO:0005001transmembrane receptor protein tyrosine phosphatase activity NAS8700514
    GO:0005515protein binding IPI10397721
    GO:0008013beta-catenin binding IPI16574648
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with PTPRU           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PTPRU:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTPRU
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPRU
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPRU

    miRNA
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    miRTarBase miRNAs that target PTPRU:
    hsa-mir-615-3p (MIRT040396), hsa-mir-335-5p (MIRT019113)

    Block miRNA regulation of human, mouse, rat PTPRU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPRU (see all 48):
    hsa-let-7d hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-1260b hsa-miR-219-5p hsa-let-7g hsa-miR-1304 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidPTPRU 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PTPRU

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRU


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTPRU_HUMAN, Q92729: Cell junction. Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS8700514
    GO:0005911cell-cell junction IDA12501215
    GO:0016020membrane ----

    Find genes that share ontologies with PTPRU           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPRU About    
    See pathways by source

    SuperPathContained pathways About
    1PI-3K cascade
    Signaling by SCF-KIT0.72
    2Signaling by GPCR
    Signal Transduction0.58
    3Development EPO induced Jak STAT pathway
    EPO Receptor Signaling0.42
    4Kit Receptor Signaling Pathway
    Kit Receptor Signaling Pathway0.37
    5PAK Pathway
    Epithelial Adherens Junctions0.36


    Find genes that share SuperPaths with PTPRU           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPRU
        Epithelial Adherens Junctions

    2 BioSystems Pathways for PTPRU
        EPO Receptor Signaling
    Kit Receptor Signaling Pathway

    1 Reactome Pathway for PTPRU
        Signaling by SCF-KIT


        Pathway & Disease-focused RT2 Profiler PCR Array including PTPRU: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPRU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for PTPRU (Q927291, 2, 3 ENSP000003349414) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KITP107211, 2, 3, ENSP000002881354EBI-7052301,EBI-1379503 MINT-8214511 MINT-8214420 I2D: score=2 STRING: ENSP00000288135
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    PPFIA3O751453, ENSP000003356144I2D: score=1 STRING: ENSP00000335614
    CTNNB1P352223, ENSP000003444564I2D: score=3 STRING: ENSP00000344456
    GNAI1P630963, ENSP000003430274I2D: score=1 STRING: ENSP00000343027
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IDA12501215
    GO:0007155cell adhesion NAS8700514
    GO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway NAS8700514
    GO:0008285negative regulation of cell proliferation IDA16574648
    GO:0016311dephosphorylation ----

    Find genes that share ontologies with PTPRU           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPRU

    2 HMDB Compounds for PTPRU    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for PTPRU gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 81.2 194 9712039 (5), 10397721 (5), 7694572 (3), 10623581 (3) (see all 99)
    phosphotyrosine 76.9 15 8601320 (2), 8687156 (2), 9109401 (2), 10591140 (1) (see all 9)
    vanadate 67.6 20 7694572 (3), 10439081 (3), 10591140 (2), 9712039 (1) (see all 9)
    phenylarsine oxide 62.9 8 8258460 (1), 9677317 (1), 9458714 (1), 10564652 (1) (see all 5)
    threonine 35.7 3 8258460 (1), 14739250 (1), 16077967 (1)
    serine 34.3 3 8258460 (1), 14739250 (1), 16077967 (1)
    genistein 30.9 3 8627784 (1), 9458714 (1)
    cysteine 27.5 3 16849327 (1), 18480265 (1), 19467874 (1)
    gf 109203x 27.2 2 10395944 (1)
    okadaic acid 12 3 9230127 (1), 10395944 (1)



    Find genes that share compounds with PTPRU           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTPRU gene (4 alternative transcripts): 
    NM_001195001.1  NM_005704.4  NM_133177.3  NM_133178.3  

    Unigene Cluster for PTPRU:

    Protein tyrosine phosphatase, receptor type, U
    Hs.19718  [show with all ESTs]
    Unigene Representative Sequence: NM_005704
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000345512 ENST00000373779(uc001bru.3 uc009vtq.3 uc009vtr.3 uc001brw.3)
    ENST00000428026(uc001brx.3) ENST00000460170 ENST00000527027 ENST00000415600
    ENST00000531385 ENST00000526080 ENST00000493601 ENST00000465525 ENST00000492954
    ENST00000356870 ENST00000323874
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    Selected qRT-PCR Assays for microRNAs that regulate PTPRU (see all 48):
    hsa-let-7d hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-1260b hsa-miR-219-5p hsa-let-7g hsa-miR-1304 hsa-miR-1276
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      QuantiTect SYBR Green Assays in human, mouse, rat PTPRU
      QuantiFast Probe-based Assays in human, mouse, rat PTPRU

    Additional mRNA sequence: 

    AB208855.1 AK094849.1 BC033131.1 BC146655.1 U71075.1 U73727.1 X95712.1 X97198.1 

    7 DOTS entries:

    DT.113509  DT.95122575  DT.91707222  DT.99933334  DT.95139414  DT.95269529  DT.95303092 

    Selected AceView cDNA sequences (see all 169):

    CR621849 AI758531 BM675977 BU731074 BQ927774 AA946811 BU687539 Z38307 
    BU682861 BM799833 BI966011 CD671734 AW297725 BM712452 BC033131 AW239467 
    AI339285 CR624372 BM667857 AL527290 NM_133177 BM825262 AW593613 CD671933 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTPRU (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^
    SP1:                                -                                                     -                 -                                   -               
    SP2:                                                                                                                                                            
    SP3:                                -                                                                                                                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                        -                                                   

    ExUns: 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
    SP1:                                      -           -                                       
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                  -                                       
    SP5:                                                                                          


    ECgene alternative splicing isoforms for PTPRU

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPRU expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGGCTCCT
    PTPRU Expression
    About this image


    PTPRU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Kidney (Urinary System)
             Metanephros
     
     Lower Urinary Tract (Urinary System)
             Ureter
    PTPRU Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPRU Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.19718

    UniProtKB/Swiss-Prot: PTPRU_HUMAN, Q92729
    Tissue specificity: High levels in brain, pancreas, and skeletal muscle; less in colon, kidney, liver, stomach,
    and uterus; not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and
    ovary. Ubiquitously expressed in brain. Expressed by hematopoietic stem cells

        Pathway & Disease-focused RT2 Profiler PCR Array including PTPRU: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PTPRU gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpru1 , 5 protein tyrosine phosphatase, receptor type, U1, 5 89.01(n)1
    95.33(a)1
      4 (64.50 cM)5
    192731  NM_001083119.21  NP_001076588.11 
     1317684575 
    chicken
    (Gallus gallus)
    Aves PTPRU1 protein tyrosine phosphatase, receptor type, U 81.19(n)
    85.68(a)
      395153  NM_204492.1  NP_989823.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTPRU6
    protein tyrosine phosphatase, receptor type, U
    81(a)
    1 ↔ 1
    GL343563.1(28599-64301)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.96232 Transcribed sequence with weak similarity to protein more 78.54(n)    BX709709.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj42a042 Transcribed sequence with moderate similarity to protein more 78.88(n)    57075549 


    ENSEMBL Gene Tree for PTPRU (if available)
    TreeFam Gene Tree for PTPRU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPRU gene
    PTPRK2  PTPRC2  PTPRA2  PTPRG2  PTPRD2  PTPRS2  PTPRM2  PTPRF2  
    PTPRZ12  PTPRT2  PTPRE2  
    16 SIMAP similar genes for PTPRU using alignment to 4 protein entries:     PTPRU_HUMAN (see all proteins):
    DKFZp686C2268    PTPRK    PTPRM    DKFZp313F1310    PTPRT    PTPRS
    PTPN5    PTPRA    DKFZp781C1038    BPTP-3    PTPN7    PTPRE
    DKFZp686K0257    DKFZp761A0712    PTPN4    PTPRR

    Find genes that share paralogs with PTPRU           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PTPRU
    PGOHUM00000251062


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPRU (see all 1864)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356524
    A colorectal cancer sample4--see VAR_0356522 R C mis40--------
    VAR_0356514
    A colorectal cancer sample4--see VAR_0356512 R W mis40--------
    VAR_0356504
    A colorectal cancer sample4--see VAR_0356502 H Y mis40--------
    rs767171781,2
    C--29561099(+) GCTCAT/CAGTTT 4 -- us2k14Minor allele frequency- C:0.17NA WA EA 360
    rs1451599611,2
    --29561188(+) TGCCCA/GGCTTC 4 -- us2k10--------
    rs579596831,2
    C,F--29561294(+) CTTCTC/TATACT 4 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1927990221,2
    --29561304(+) TTCAGG/TTCTCA 4 -- us2k10--------
    rs1855465481,2
    --29561320(+) AATGTC/TACCAT 4 -- us2k10--------
    rs1390369561,2
    --29561344(+) CAAAGC/TCCTCT 4 -- us2k10--------
    rs1113215681,2
    F--29561385(+) CCCTAC/TGTTCT 4 -- us2k11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for PTPRU (29563028 - 29653325 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PTPRU:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834546CNV Loss17160897
    nsv822220CNV Gain20364138
    nsv871249CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602454    OMIM disorders: --


    Find genes that share disorders with PTPRU           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PTPRU gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma t-cell 19.7 7 9070223 (2), 10395944 (2), 8258460 (1)
    diabetes mellitus insulin-dependent 5.91 1 8798755 (1)
    metastasis 5.37 1 12570871 (1)
    leukemia 3.6 1 15634593 (1)
    ischemia 0 1 11501180 (1)
    breast cancer 0 5 15363463 (1), 8687156 (1), 10365916 (1)
    glioblastoma 0 2 15659806 (1), 17085782 (1)
    tumors 0 11 8687156 (2), 18644370 (1), 18385452 (1), 19936768 (1) (see all 5)
    alzheimers disease 0 1 8376411 (1)
    carcinoma 0 2 8663237 (1), 9115287 (1)

    Genetic Association Database (GAD): PTPRU
    Human Genome Epidemiology (HuGE) Navigator: PTPRU (2 documents)

    Export disorders for PTPRU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPRU gene, integrated from 10 sources (see all 202):
    (articles sorted by number of sources associating them with PTPRU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family. (PubMed id 8700514)1, 2, 3, 9 Wang H.-Y.... Ullrich A. (Oncogene 1996)
    2. Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells. (PubMed id 9434160)1, 2, 3 Avraham S.... Avraham H. (Gene 1997)
    3. The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and is associated with the c-Kit receptor. (PubMed id 10397721)1, 2, 9 Taniguchi Y.... Avraham H. (Blood 1999)
    4. Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells. (PubMed id 10395944)1, 2, 9 Wang B.... Nomoto K. (Biochim. Biophys. Acta 1999)
    5. Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells. (PubMed id 9070223)1, 2, 9 Wang B.... Nomoto K. (Biochem. Biophys. Res. Commun. 1997)
    6. Molecular cloning and characterization of PTP pi, a novel receptor- like protein-tyrosine phosphatase. (PubMed id 8870675)1, 2, 9 Crossland S.... Crompton M.R. (Biochem. J. 1996)
    7. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (Carcinogenesis 2012)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PubMed id 20889312)1, 4 Wang K.S....Aragam N. (Schizophr. Res. 2010)
    10. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1, 4 Anney R.J....Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10076 HGNC: 9683 AceView: PTPRU Ensembl:ENSG00000060656 euGenes: HUgn10076
    ECgene: PTPRU H-InvDB: PTPRU

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPRU Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPRU Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPRU gene:
    Search GeneIP for patents involving PTPRU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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