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Aliases for PTPRT Gene

Aliases for PTPRT Gene

  • Protein Tyrosine Phosphatase, Receptor Type T 2 3
  • Receptor-Type Tyrosine-Protein Phosphatase Rho 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, T 3 5
  • EC 3.1.3.48 4 63
  • RPTP-Rho 3 4
  • R-PTP-T 3 4
  • Receptor Protein Tyrosine Phosphatase 3
  • KIAA0283 4
  • EC 3.1.3 63
  • RPTPrho 3

External Ids for PTPRT Gene

Previous GeneCards Identifiers for PTPRT Gene

  • GC20M040429
  • GC20M041339
  • GC20M041386
  • GC20M040134
  • GC20M040701
  • GC20M037438

Summaries for PTPRT Gene

Entrez Gene Summary for PTPRT Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRT Gene

PTPRT (Protein Tyrosine Phosphatase, Receptor Type T) is a Protein Coding gene. Among its related pathways are PAK Pathway. GO annotations related to this gene include phosphatase activity and beta-catenin binding. An important paralog of this gene is PTPRK.

UniProtKB/Swiss-Prot for PTPRT Gene

  • May be involved in both signal transduction and cellular adhesion in the CNS.

Gene Wiki entry for PTPRT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRT Gene

Genomics for PTPRT Gene

Regulatory Elements for PTPRT Gene

Genomic Location for PTPRT Gene

Chromosome:
20
Start:
42,072,752 bp from pter
End:
43,189,970 bp from pter
Size:
1,117,219 bases
Orientation:
Minus strand

Genomic View for PTPRT Gene

Genes around PTPRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRT Gene

Proteins for PTPRT Gene

  • Protein details for PTPRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14522-PTPRT_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase T
    Protein Accession:
    O14522
    Secondary Accessions:
    • A8E4R6
    • O43655
    • O75664
    • Q5W0X9
    • Q5W0Y1
    • Q9BR24
    • Q9BR28
    • Q9H0Y8
    • Q9NTL1
    • Q9NU72
    • Q9UBD2
    • Q9UJL7

    Protein attributes for PTPRT Gene

    Size:
    1441 amino acids
    Molecular mass:
    162134 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA22952.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH72555.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19251.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19867.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19879.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19983.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20439.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22491.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22911.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRT Gene

    Alternative splice isoforms for PTPRT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRT Gene

Proteomics data for PTPRT Gene at MOPED

Post-translational modifications for PTPRT Gene

  • Glycosylation at Asn 78, Asn 98, Asn 137, Asn 208, Asn 421, Asn 510, Asn 547, Asn 601, Asn 654, and Asn 684
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PTPRT (PTP rho/PTPRT)

Domains & Families for PTPRT Gene

Suggested Antigen Peptide Sequences for PTPRT Gene

Graphical View of Domain Structure for InterPro Entry

O14522

UniProtKB/Swiss-Prot:

PTPRT_HUMAN :
  • Contains 4 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Domain:
  • Contains 4 fibronectin type-III domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 MAM domain.
  • Contains 2 tyrosine-protein phosphatase domains.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
genes like me logo Genes that share domains with PTPRT: view

Function for PTPRT Gene

Molecular function for PTPRT Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor type,T,expressed in the brain and delineating with FGF1,a retrocaudal boundary in the granule cell layer of the (murine) cerebellar cortex
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
May be involved in both signal transduction and cellular adhesion in the CNS.

Enzyme Numbers (IUBMB) for PTPRT Gene

Gene Ontology (GO) - Molecular Function for PTPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IMP 16973135
GO:0005515 protein binding IEA,IPI 16273344
GO:0008013 beta-catenin binding IPI 16973135
GO:0045294 alpha-catenin binding IDA 16973135
GO:0045295 gamma-catenin binding IDA 16973135
genes like me logo Genes that share ontologies with PTPRT: view
genes like me logo Genes that share phenotypes with PTPRT: view

Animal Models for PTPRT Gene

MGI Knock Outs for PTPRT:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRT Gene

Localization for PTPRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRT Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRT Gene COMPARTMENTS Subcellular localization image for PTPRT gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PTPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 9602027
genes like me logo Genes that share ontologies with PTPRT: view

Pathways & Interactions for PTPRT Gene

SuperPathways for PTPRT Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPRT: view

Pathways by source for PTPRT Gene

1 Qiagen pathway for PTPRT Gene

Gene Ontology (GO) - Biological Process for PTPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,IDA 16973135
GO:0007155 cell adhesion NAS 16973135
GO:0007165 signal transduction NAS 16973135
genes like me logo Genes that share ontologies with PTPRT: view

No data available for SIGNOR curated interactions for PTPRT Gene

Drugs & Compounds for PTPRT Gene

(1) Drugs for PTPRT Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for PTPRT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTPRT: view

Transcripts for PTPRT Gene

mRNA/cDNA for PTPRT Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTPRT Gene

Protein tyrosine phosphatase, receptor type, T:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRT Gene

No ASD Table

Relevant External Links for PTPRT Gene

GeneLoc Exon Structure for
PTPRT
ECgene alternative splicing isoforms for
PTPRT

Expression for PTPRT Gene

mRNA expression in normal human tissues for PTPRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRT Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x10.7), Brain - Cortex (x9.4), and Brain - Anterior cingulate cortex (BA24) (x8.4).

Protein differential expression in normal tissues from HIPED for PTPRT Gene

This gene is overexpressed in Stomach (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTPRT Gene



SOURCE GeneReport for Unigene cluster for PTPRT Gene Hs.526879

mRNA Expression by UniProt/SwissProt for PTPRT Gene

O14522-PTPRT_HUMAN
Tissue specificity: Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with PTPRT: view

Protein tissue co-expression partners for PTPRT Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PTPRT Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRT 35
  • 92.14 (n)
  • 98.67 (a)
PTPRT 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRT 35
  • 92.82 (n)
  • 99.49 (a)
PTPRT 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprt 35
  • 90.66 (n)
  • 99.08 (a)
Ptprt 16
Ptprt 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPRT 35
  • 99.54 (n)
  • 99.73 (a)
PTPRT 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPRT 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRT 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRT 35
  • 81.69 (n)
  • 93.95 (a)
PTPRT 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRT 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprt 35
  • 77.38 (n)
  • 85.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia ptprt-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii ptprt 36
  • 81 (a)
OneToMany
PTPRT (2 of 2) 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7180 37
  • 33 (a)
Ptp69D 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea C17H12.3 37
  • 38 (a)
C55B7.3 37
  • 33 (a)
F10G8.1 37
  • 31 (a)
F36H1.3 37
  • 37 (a)
F47B3.7 37
  • 35 (a)
Y48G9A.9 37
  • 37 (a)
ZK484.7 37
  • 33 (a)
ZK616.7 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1390 36
  • 38 (a)
OneToMany
Species with no ortholog for PTPRT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRT Gene

ENSEMBL:
Gene Tree for PTPRT (if available)
TreeFam:
Gene Tree for PTPRT (if available)

Paralogs for PTPRT Gene

Paralogs for PTPRT Gene

genes like me logo Genes that share paralogs with PTPRT: view

Variants for PTPRT Gene

Sequence variations from dbSNP and Humsavar for PTPRT Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_020746 A colorectal cancer
VAR_020747 Some colorectal cancers
VAR_020748 A gastric cancer
VAR_020749 A colorectal cancer
VAR_020750 A colorectal cancer

Structural Variations from Database of Genomic Variants (DGV) for PTPRT Gene

Variant ID Type Subtype PubMed ID
nsv3381 CNV Loss 18451855
esv2751913 CNV Gain 17911159
esv995175 CNV Deletion 20482838
nsv180358 CNV Insertion 16902084
esv7918 CNV Loss 19470904
esv2722424 CNV Deletion 23290073
esv2256655 CNV Deletion 18987734
nsv179776 CNV Loss 16902084
esv2232474 CNV Deletion 18987734
esv2722425 CNV Deletion 23290073
nsv912874 CNV Gain 21882294
nsv523080 CNV Gain 19592680
nsv516291 CNV Gain+Loss 19592680
esv2669794 CNV Deletion 23128226
esv2658478 CNV Deletion 23128226
nsv833987 CNV Loss 17160897
esv2488032 CNV Deletion 19546169
esv2722426 CNV Deletion 23290073
esv2722427 CNV Deletion 23290073
esv989547 CNV Deletion 20482838
esv2722429 CNV Deletion 23290073
nsv828726 CNV Loss 20364138
esv2722430 CNV Deletion 23290073
esv1938054 CNV Deletion 18987734
nsv458978 CNV Loss 19166990
nsv912875 CNV Loss 21882294
nsv519654 CNV Loss 19592680
nsv912876 CNV Loss 21882294
nsv912877 CNV Loss 21882294
dgv247n21 CNV Loss 19592680
esv2661822 CNV Deletion 23128226
esv2670325 CNV Deletion 23128226
nsv458979 CNV Loss 19166990
esv2657780 CNV Deletion 23128226
nsv912878 CNV Gain 21882294
nsv833988 CNV Loss 17160897
dgv4569n71 CNV Loss 21882294
nsv458981 CNV Loss 19166990
dgv4570n71 CNV Loss 21882294
nsv912885 CNV Loss 21882294
esv2664344 CNV Deletion 23128226
dgv1328e1 CNV Complex 17122850
nsv817896 CNV Loss 17921354
esv2668973 CNV Deletion 23128226
nsv517647 CNV Loss 19592680
nsv470552 CNV Loss 18288195
nsv458982 CNV Loss 19166990
esv2674976 CNV Deletion 23128226
nsv522445 CNV Loss 19592680
nsv523956 CNV Loss 19592680
nsv3383 CNV Insertion 18451855
dgv788e199 CNV Deletion 23128226
esv2722431 CNV Deletion 23290073
esv2722432 CNV Deletion 23290073
esv2477377 CNV Insertion 19546169
esv1402978 CNV Insertion 17803354
esv2722433 CNV Deletion 23290073
nsv912889 CNV Loss 21882294
esv2617939 CNV Insertion 19546169
esv2436042 CNV Insertion 19546169
esv1713499 CNV Insertion 17803354
esv1651732 CNV Insertion 17803354
esv2722434 CNV Deletion 23290073
esv2658951 CNV Deletion 23128226
esv33863 CNV Loss 17666407
esv2751914 CNV Gain 17911159
nsv525353 CNV Loss 19592680
esv2664766 CNV Deletion 23128226
esv2722435 CNV Deletion 23290073
esv2722436 CNV Deletion 23290073

Variation tolerance for PTPRT Gene

Residual Variation Intolerance Score: 3.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRT Gene

HapMap Linkage Disequilibrium report
PTPRT
Human Gene Mutation Database (HGMD)
PTPRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRT Gene

Disorders for PTPRT Gene

Relevant External Links for PTPRT

Genetic Association Database (GAD)
PTPRT
Human Genome Epidemiology (HuGE) Navigator
PTPRT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRT

No disorders were found for PTPRT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPRT Gene

Publications for PTPRT Gene

  1. Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system. (PMID: 9602027) McAndrew P.E. … Burghes A.H.M. (Brain Res. Mol. Brain Res. 1998) 2 3 4 23 67
  2. Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. (PMID: 20133777) Zhao Y. … Wang Z. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  3. Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn. (PMID: 19816407) Lim S.H. … Lee J.R. (EMBO J. 2009) 3 23
  4. Mutational analysis of PTPRT phosphatase domains in common human cancers. (PMID: 17223850) Lee J.W. … Lee S.H. (APMIS 2007) 3 23
  5. Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. (PMID: 17360477) Zhang X. … Wang Z.J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23

Products for PTPRT Gene

Sources for PTPRT Gene

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