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Aliases for PTPRT Gene

Aliases for PTPRT Gene

  • Protein Tyrosine Phosphatase, Receptor Type T 2 3 5
  • Receptor-Type Tyrosine-Protein Phosphatase Rho 3 4
  • EC 3.1.3.48 4 61
  • RPTP-Rho 3 4
  • R-PTP-T 3 4
  • Receptor-Type Tyrosine-Protein Phosphatase T 3
  • Receptor Protein Tyrosine Phosphatase 3
  • KIAA0283 4
  • EC 3.1.3 61
  • RPTPrho 3

External Ids for PTPRT Gene

Previous GeneCards Identifiers for PTPRT Gene

  • GC20M040429
  • GC20M041339
  • GC20M041386
  • GC20M040134
  • GC20M040701
  • GC20M037438

Summaries for PTPRT Gene

Entrez Gene Summary for PTPRT Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

CIViC summary for PTPRT Gene

GeneCards Summary for PTPRT Gene

PTPRT (Protein Tyrosine Phosphatase, Receptor Type T) is a Protein Coding gene. Among its related pathways are PAK Pathway. GO annotations related to this gene include phosphatase activity and beta-catenin binding. An important paralog of this gene is PTPRM.

UniProtKB/Swiss-Prot for PTPRT Gene

  • May be involved in both signal transduction and cellular adhesion in the CNS.

Gene Wiki entry for PTPRT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRT Gene

Genomics for PTPRT Gene

Regulatory Elements for PTPRT Gene

Enhancers for PTPRT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G043964 0.7 dbSUPER 5.1 -773.4 -773406 0.7 ATF1 TFE3 MLX RNF2 ZHX2 HBP1 ATF2 NCOR1 ADNP HNF4G TOX2 PTPRT RN7SL443P
GH20G043490 0.5 FANTOM5 1.8 -300.3 -300330 0.3 FOXA2 CEBPB SGK2 TOX2 PTPRT L3MBTL1 RNU6-1251P
GH20G043018 0.3 FANTOM5 2.8 +171.0 170950 0.2 PTPRT L3MBTL1 PIR52989 LOC101927138
GH20G043187 0.7 ENCODE 0.7 +2.0 2035 0.2 CTCF ZNF654 MIER1 TRIM22 CBX2 MIER2 REST EP300 RAD21 ZNF143 PTPRT GC20P043105
GH20G043183 0.4 ENCODE 0.4 +6.1 6055 0.2 ATF2 ZNF507 PTPRT GC20P043105
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTPRT on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPRT Gene

Chromosome:
20
Start:
42,072,752 bp from pter
End:
43,189,970 bp from pter
Size:
1,117,219 bases
Orientation:
Minus strand

Genomic View for PTPRT Gene

Genes around PTPRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRT Gene

Proteins for PTPRT Gene

  • Protein details for PTPRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14522-PTPRT_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase T
    Protein Accession:
    O14522
    Secondary Accessions:
    • A8E4R6
    • O43655
    • O75664
    • Q5W0X9
    • Q5W0Y1
    • Q9BR24
    • Q9BR28
    • Q9H0Y8
    • Q9NTL1
    • Q9NU72
    • Q9UBD2
    • Q9UJL7

    Protein attributes for PTPRT Gene

    Size:
    1441 amino acids
    Molecular mass:
    162134 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA22952.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH72555.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19251.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19867.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19879.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19983.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20439.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22491.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22911.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRT Gene

    Alternative splice isoforms for PTPRT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRT Gene

Selected DME Specific Peptides for PTPRT Gene

O14522:
  • WPDHGVP
  • NYINAAL
  • PFTVGDN
  • RVADLLQHI
  • LVEVGRVKC
  • VQTEEQY
  • LRLLLSN
  • YIATQGP
  • HCLNGGGRSG
  • AELIVKEPPTPIAPP
  • KENDTHCIDF
  • GRTGCFI
  • NSIIGDGPI
  • VLLTRPGEGGTG
  • TYNGYWN
  • VVHCSAG
  • PIVVHCS
  • DRCLPFLI
  • YKLWHLDPD
  • DYINANY

Post-translational modifications for PTPRT Gene

  • Glycosylation at Asn78, Asn98, Asn137, isoforms=3208, Asn421, isoforms=3510, Asn547, Asn601, isoforms=3654, and isoforms=3684
  • Modification sites at PhosphoSitePlus

Domains & Families for PTPRT Gene

Suggested Antigen Peptide Sequences for PTPRT Gene

Graphical View of Domain Structure for InterPro Entry

O14522

UniProtKB/Swiss-Prot:

PTPRT_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
genes like me logo Genes that share domains with PTPRT: view

Function for PTPRT Gene

Molecular function for PTPRT Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor type,T,expressed in the brain and delineating with FGF1,a retrocaudal boundary in the granule cell layer of the (murine) cerebellar cortex
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
May be involved in both signal transduction and cellular adhesion in the CNS.

Enzyme Numbers (IUBMB) for PTPRT Gene

Gene Ontology (GO) - Molecular Function for PTPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA,IMP 16973135
GO:0005515 protein binding IPI 16273344
GO:0008013 beta-catenin binding IPI 16973135
GO:0016787 hydrolase activity IEA --
GO:0016790 thiolester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PTPRT: view
genes like me logo Genes that share phenotypes with PTPRT: view

Animal Models for PTPRT Gene

MGI Knock Outs for PTPRT:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPRT

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTPRT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRT Gene

Localization for PTPRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRT Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRT gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PTPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 18644975
GO:0009986 cell surface IDA 18644975
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS,IEA 9602027
genes like me logo Genes that share ontologies with PTPRT: view

Pathways & Interactions for PTPRT Gene

SuperPathways for PTPRT Gene

SuperPathway Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPRT: view

Pathways by source for PTPRT Gene

1 Qiagen pathway for PTPRT Gene

Gene Ontology (GO) - Biological Process for PTPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IDA,IEA 16973135
GO:0007155 cell adhesion NAS 16973135
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA 18644975
GO:0007165 signal transduction NAS 16973135
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IMP 16973135
genes like me logo Genes that share ontologies with PTPRT: view

No data available for SIGNOR curated interactions for PTPRT Gene

Drugs & Compounds for PTPRT Gene

(3) Drugs for PTPRT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for PTPRT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PTPRT: view

Transcripts for PTPRT Gene

Unigene Clusters for PTPRT Gene

Protein tyrosine phosphatase, receptor type, T:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTPRT

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRT Gene

No ASD Table

Relevant External Links for PTPRT Gene

GeneLoc Exon Structure for
PTPRT
ECgene alternative splicing isoforms for
PTPRT

Expression for PTPRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTPRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRT Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x10.7), Brain - Cortex (x9.4), and Brain - Anterior cingulate cortex (BA24) (x8.4).

Protein differential expression in normal tissues from HIPED for PTPRT Gene

This gene is overexpressed in Stomach (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTPRT Gene



Protein tissue co-expression partners for PTPRT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTPRT Gene:

PTPRT

SOURCE GeneReport for Unigene cluster for PTPRT Gene:

Hs.526879

mRNA Expression by UniProt/SwissProt for PTPRT Gene:

O14522-PTPRT_HUMAN
Tissue specificity: Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for PTPRT Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with PTPRT: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRT Gene

Orthologs for PTPRT Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRT 34 35
  • 99.54 (n)
oppossum
(Monodelphis domestica)
Mammalia PTPRT 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRT 34 35
  • 92.82 (n)
cow
(Bos Taurus)
Mammalia PTPRT 34 35
  • 92.14 (n)
mouse
(Mus musculus)
Mammalia Ptprt 34 16 35
  • 90.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRT 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRT 34 35
  • 81.69 (n)
lizard
(Anolis carolinensis)
Reptilia PTPRT 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprt 34
  • 77.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia ptprt-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii PTPRT (2 of 2) 35
  • 86 (a)
OneToMany
ptprt 35
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7180 36
  • 33 (a)
Ptp69D 36
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea C17H12.3 36
  • 38 (a)
F36H1.3 36
  • 37 (a)
Y48G9A.9 36
  • 37 (a)
F47B3.7 36
  • 35 (a)
ZK616.7 36
  • 35 (a)
C55B7.3 36
  • 33 (a)
ZK484.7 36
  • 33 (a)
F10G8.1 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1390 35
  • 38 (a)
OneToMany
Species where no ortholog for PTPRT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRT Gene

ENSEMBL:
Gene Tree for PTPRT (if available)
TreeFam:
Gene Tree for PTPRT (if available)

Paralogs for PTPRT Gene

Variants for PTPRT Gene

Sequence variations from dbSNP and Humsavar for PTPRT Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs370873414 A colorectal cancer 42,102,270(+) GGGCC(A/G)CACAC intron-variant, reference, missense
rs749647294 A colorectal cancer 42,448,250(+) GTCTC(A/T)TTGGG reference, missense
rs761148007 A colorectal cancer 42,098,528(+) GACCA(C/G/T)GAAGG intron-variant, reference, missense
VAR_020746 A colorectal cancer
VAR_020747 Some colorectal cancers

Structural Variations from Database of Genomic Variants (DGV) for PTPRT Gene

Variant ID Type Subtype PubMed ID
dgv1243e212 CNV loss 25503493
dgv1244e212 CNV loss 25503493
dgv1245e212 CNV loss 25503493
dgv2251n106 CNV deletion 24896259
dgv247n21 CNV loss 19592680
dgv4310n100 CNV loss 25217958
dgv4311n100 CNV loss 25217958
dgv4312n100 CNV loss 25217958
dgv4313n100 CNV loss 25217958
dgv4314n100 CNV loss 25217958
dgv4315n100 CNV loss 25217958
dgv4316n100 CNV loss 25217958
dgv4317n100 CNV gain 25217958
dgv4318n100 CNV gain 25217958
dgv7575n54 CNV loss 21841781
dgv7576n54 CNV loss 21841781
dgv7577n54 CNV loss 21841781
dgv7578n54 CNV loss 21841781
dgv7579n54 CNV loss 21841781
dgv7580n54 CNV loss 21841781
dgv782e214 CNV loss 21293372
dgv788e199 CNV deletion 23128226
esv1402978 CNV insertion 17803354
esv1651732 CNV insertion 17803354
esv1713499 CNV insertion 17803354
esv1938054 CNV deletion 18987734
esv2232474 CNV deletion 18987734
esv2256655 CNV deletion 18987734
esv2436042 CNV insertion 19546169
esv2477377 CNV insertion 19546169
esv2488032 CNV deletion 19546169
esv2617939 CNV insertion 19546169
esv2657780 CNV deletion 23128226
esv2658478 CNV deletion 23128226
esv2658951 CNV deletion 23128226
esv2661822 CNV deletion 23128226
esv2664344 CNV deletion 23128226
esv2664766 CNV deletion 23128226
esv2668973 CNV deletion 23128226
esv2669794 CNV deletion 23128226
esv2670325 CNV deletion 23128226
esv2674976 CNV deletion 23128226
esv2722424 CNV deletion 23290073
esv2722425 CNV deletion 23290073
esv2722426 CNV deletion 23290073
esv2722427 CNV deletion 23290073
esv2722429 CNV deletion 23290073
esv2722430 CNV deletion 23290073
esv2722431 CNV deletion 23290073
esv2722432 CNV deletion 23290073
esv2722433 CNV deletion 23290073
esv2722434 CNV deletion 23290073
esv2722435 CNV deletion 23290073
esv2722436 CNV deletion 23290073
esv2751913 CNV gain 17911159
esv2751914 CNV gain 17911159
esv2758795 CNV loss 17122850
esv2760672 CNV loss 21179565
esv2762074 CNV loss 21179565
esv2762075 CNV loss 21179565
esv2762078 CNV loss 21179565
esv3324213 CNV insertion 20981092
esv33863 CNV loss 17666407
esv3557084 CNV deletion 23714750
esv3557085 CNV deletion 23714750
esv3557087 CNV deletion 23714750
esv3557090 CNV deletion 23714750
esv3557093 CNV deletion 23714750
esv3557094 CNV deletion 23714750
esv3567969 CNV loss 25503493
esv3567970 CNV loss 25503493
esv3567971 CNV loss 25503493
esv3567972 CNV loss 25503493
esv3567977 CNV loss 25503493
esv3575373 CNV gain 25503493
esv3645841 CNV gain 21293372
esv3645854 CNV gain 21293372
esv3645856 CNV gain 21293372
esv3645857 CNV loss 21293372
esv3645858 CNV loss 21293372
esv3645859 CNV loss 21293372
esv3645861 CNV loss 21293372
esv3645863 CNV loss 21293372
esv3645864 CNV loss 21293372
esv3645865 CNV loss 21293372
esv3645866 CNV loss 21293372
esv3645867 CNV loss 21293372
esv3645868 CNV loss 21293372
esv3645872 CNV loss 21293372
esv3645873 CNV loss 21293372
esv3645875 CNV loss 21293372
esv3645876 CNV loss 21293372
esv3645877 CNV loss 21293372
esv3893334 CNV loss 25118596
esv3893335 CNV loss 25118596
esv3893336 CNV loss 25118596
esv3893338 CNV loss 25118596
esv3893339 CNV loss 25118596
esv7918 CNV loss 19470904
esv989547 CNV deletion 20482838
esv995175 CNV deletion 20482838
nsv1055546 CNV loss 25217958
nsv1057847 CNV loss 25217958
nsv1060878 CNV loss 25217958
nsv1061219 CNV loss 25217958
nsv1061449 CNV loss 25217958
nsv1063422 CNV loss 25217958
nsv1063770 CNV loss 25217958
nsv1064246 CNV loss 25217958
nsv1064358 CNV loss 25217958
nsv1065268 CNV loss 25217958
nsv1072114 CNV deletion 25765185
nsv1073059 CNV deletion 25765185
nsv1123488 CNV deletion 24896259
nsv1125727 CNV tandem duplication 24896259
nsv1126596 CNV deletion 24896259
nsv1136541 CNV deletion 24896259
nsv1136543 CNV deletion 24896259
nsv1136544 CNV deletion 24896259
nsv179776 CNV deletion 16902084
nsv180358 CNV insertion 16902084
nsv3381 CNV deletion 18451855
nsv3383 CNV insertion 18451855
nsv458978 CNV loss 19166990
nsv458979 CNV loss 19166990
nsv458981 CNV loss 19166990
nsv458982 CNV loss 19166990
nsv470552 CNV loss 18288195
nsv474634 CNV novel sequence insertion 20440878
nsv478938 CNV novel sequence insertion 20440878
nsv516291 CNV gain+loss 19592680
nsv517647 CNV loss 19592680
nsv519654 CNV loss 19592680
nsv522445 CNV loss 19592680
nsv523080 CNV gain 19592680
nsv523956 CNV loss 19592680
nsv525353 CNV loss 19592680
nsv586007 CNV loss 21841781
nsv586008 CNV loss 21841781
nsv586010 CNV loss 21841781
nsv586025 CNV loss 21841781
nsv586028 CNV loss 21841781
nsv817896 CNV loss 17921354
nsv828726 CNV loss 20364138
nsv833987 CNV loss 17160897
nsv833988 CNV loss 17160897
nsv954042 CNV deletion 24416366
nsv954263 CNV deletion 24416366

Variation tolerance for PTPRT Gene

Residual Variation Intolerance Score: 3.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRT Gene

Human Gene Mutation Database (HGMD)
PTPRT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRT Gene

Disorders for PTPRT Gene

Relevant External Links for PTPRT

Genetic Association Database (GAD)
PTPRT
Human Genome Epidemiology (HuGE) Navigator
PTPRT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRT

No disorders were found for PTPRT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPRT Gene

Publications for PTPRT Gene

  1. Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system. (PMID: 9602027) McAndrew P.E. … Burghes A.H.M. (Brain Res. Mol. Brain Res. 1998) 2 3 4 22 64
  2. Mutational analysis of PTPRT phosphatase domains in common human cancers. (PMID: 17223850) Lee J.W. … Lee S.H. (APMIS 2007) 3 22 46 64
  3. Genomic organization and alternative splicing of the human and mouse RPTPrho genes. (PMID: 11423001) Besco J.A. … Rotter A. (BMC Genomics 2001) 3 4 22 64
  4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for PTPRT Gene

  • Addgene plasmids for PTPRT

Sources for PTPRT Gene

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