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Aliases for PTPRS Gene

Aliases for PTPRS Gene

  • Protein Tyrosine Phosphatase, Receptor Type S 2 3 5
  • Receptor-Type Tyrosine-Protein Phosphatase Sigma 3 4
  • R-PTP-Sigma 3 4
  • EC 3.1.3.48 4 61
  • R-PTP-S 3 4
  • Receptor-Type Tyrosine-Protein Phosphatase S 3
  • Protein Tyrosine Phosphatase PTPsigma 3
  • PTPSIGMA 3

External Ids for PTPRS Gene

Previous GeneCards Identifiers for PTPRS Gene

  • GC19M005298
  • GC19M005146
  • GC19M004967

Summaries for PTPRS Gene

Entrez Gene Summary for PTPRS Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRS Gene

PTPRS (Protein Tyrosine Phosphatase, Receptor Type S) is a Protein Coding gene. Diseases associated with PTPRS include Pineal Gland Cancer and Ureterocele. Among its related pathways are Protein-protein interactions at synapses and SALM protein interactions at the synapses. GO annotations related to this gene include phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRD.

UniProtKB/Swiss-Prot for PTPRS Gene

  • Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).

Gene Wiki entry for PTPRS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRS Gene

Genomics for PTPRS Gene

Regulatory Elements for PTPRS Gene

Enhancers for PTPRS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G005308 1.3 Ensembl ENCODE 17.9 +31.6 31627 1.6 HNRNPUL1 SIN3A FEZF1 ZNF2 ZNF302 ZNF263 SP3 REST ZNF610 ZSCAN16 ENSG00000267571 ENSG00000267030 ENSG00000267255 VMAC SH3GL1 DPP9-AS1 PTPRS ENSG00000267769 SAFB SNRPEP4
GH19G005138 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +201.4 201379 0.9 HDGF ATF1 TBL1XR1 ZBTB40 ZNF121 ZNF143 RELB ETV6 IKZF2 CREM PTPRS PIR36975 GC19P005127
GH19G005339 1.2 FANTOM5 ENCODE 14.2 +1.2 1157 0.3 ATF1 ZNF76 GLIS2 IKZF2 CREM SP3 ZEB2 ZNF398 PPARG SMARCA4 PTPRS HSD11B1L LOC105372252
GH19G005045 1.5 Ensembl ENCODE dbSUPER 10.6 +292.8 292816 4.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZNF48 GLIS2 ZNF143 FOS PLIN3 PTPRS ZNRF4 UHRF1 GC19P005074 GC19M004987
GH19G005536 1.5 FANTOM5 Ensembl ENCODE 10.6 -196.3 -196281 2.0 KLF17 FEZF1 ZNF2 ZNF335 GLIS2 ZNF366 ZNF548 EGR2 ZNF263 ZNF362 SAFB SNRPEP4 PTPRS DPP9-AS1 LONP1 GC19M005554 GC19M005514
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTPRS on UCSC Golden Path with GeneCards custom track

Promoters for PTPRS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106368 503 1401 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143

Genomic Location for PTPRS Gene

Chromosome:
19
Start:
5,158,495 bp from pter
End:
5,340,803 bp from pter
Size:
182,309 bases
Orientation:
Minus strand

Genomic View for PTPRS Gene

Genes around PTPRS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRS Gene

Proteins for PTPRS Gene

  • Protein details for PTPRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13332-PTPRS_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase S
    Protein Accession:
    Q13332
    Secondary Accessions:
    • O75255
    • O75870
    • Q15718
    • Q16341
    • Q2M3R7

    Protein attributes for PTPRS Gene

    Size:
    1948 amino acids
    Molecular mass:
    217041 Da
    Quaternary structure:
    • Binding to large heparan sulfate proteoglycan structures promotes oligomerization. Binding to chondroitin sulfate proteoglycan does not lead to oligomerization (By similarity). Interacts (via Ig-like domains) with NTRK3 (PubMed:25385546). Interacts (via Ig-like domains) with NTRK1, but does not form detectable complexes with NTRK2 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3 (PubMed:8524829, PubMed:9624153).
    SequenceCaution:
    • Sequence=AAC50567.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRS Gene

    Alternative splice isoforms for PTPRS Gene

neXtProt entry for PTPRS Gene

Selected DME Specific Peptides for PTPRS Gene

Q13332:
  • PTPFLAFLRRVKTCNPPDAGP
  • DPVEMRR
  • LREFKVTDARDG
  • ERLKAND
  • LPCNKFKNRLVNI
  • YIATQGP
  • EMGREKC
  • VMLTKLRE
  • MVQTEDQY
  • SRTVRQFQF
  • VLRIQPLR
  • VGPGPESSPV
  • IAYDHSRV
  • GRNVLEL
  • PMPYVKWM
  • VVHCSAG
  • NASFIDGYR
  • VHCSAGVGRTG
  • PGQQFTW
  • SGGVASFVCQA
  • DYINASF
  • GVFITLSIVLERM
  • TRYSIGGLSP
  • MKTSVLL
  • RTATMLCAA
  • DYINANY
  • VMMTRLEE
  • PANLYVR
  • AVGSPMP
  • KCHQYWP
  • AEYNMPQY
  • WPDHGVP
  • GEGFIDFIGQVHKTKEQFGQ
  • WEEPVEPNGLI
  • ANLPCNK
  • QHGQIRGYQV
  • DFWRMVW
  • GAEDLTPEDDMP
  • KCDQYWP
  • GRTGCFI
  • RTGEQAP
  • VRRVAPRFSI
  • IDMGPQLKVVE
  • DQGKYEC
  • GNPDPEI
  • RGTETYG
  • DWPEQGVPK
  • VNIMPYE
  • SKAHTSRF
  • HKGATYVFRLAA
  • PIVVHCS
  • FRLAARSPQGLGA
  • RQFQFTDWPEQG
  • NGRIKQLRS
  • LPETFGDFWRM
  • TSVGDGP
  • GYRVYYT
  • GPVLAVVFIICIVIAILLYK

Post-translational modifications for PTPRS Gene

  • A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called ectodomain shedding is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).
  • Glycosylation at Asn263, isoforms=6, 7, 5, 2, 3, 4308, isoforms=6, 2, 3, 4733, and isoforms=6, 2, 3, 4940
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PTPRS (PTP sigma/PTPRS)
  • Santa Cruz Biotechnology (SCBT) Antibodies for PTPRS

Domains & Families for PTPRS Gene

Graphical View of Domain Structure for InterPro Entry

Q13332

UniProtKB/Swiss-Prot:

PTPRS_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
genes like me logo Genes that share domains with PTPRS: view

Function for PTPRS Gene

Molecular function for PTPRS Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type sigma,putatively involved in the development of the nervous system
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).

Enzyme Numbers (IUBMB) for PTPRS Gene

Gene Ontology (GO) - Molecular Function for PTPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IDA 8524829
GO:0004725 protein tyrosine phosphatase activity IEA,ISS --
GO:0005515 protein binding IPI 16273344
GO:0008201 heparin binding ISS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PTPRS: view
genes like me logo Genes that share phenotypes with PTPRS: view

Animal Models for PTPRS Gene

MGI Knock Outs for PTPRS:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRS Gene

Localization for PTPRS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRS Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Is rapidly internalized when dendritic cells are stimulated with the TLR9 ligand cytidine-phosphate-guanosine (CpG) (PubMed:26231120). Detected in a punctate pattern along neurites and axon growth cones (By similarity). {ECO:0000250 UniProtKB:B0V2N1, ECO:0000269 PubMed:26231120}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRS gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 2
cytosol 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8524829
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with PTPRS: view

Pathways & Interactions for PTPRS Gene

genes like me logo Genes that share pathways with PTPRS: view

SIGNOR curated interactions for PTPRS Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PTPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IDA,IEA 8524829
GO:0007155 cell adhesion IEA --
GO:0010977 negative regulation of neuron projection development ISS --
GO:0016311 dephosphorylation IEA --
GO:0021510 spinal cord development IEA --
genes like me logo Genes that share ontologies with PTPRS: view

Drugs & Compounds for PTPRS Gene

(5) Drugs for PTPRS Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Etidronic acid Approved Pharma Target, inhibitor 82
Alendronate Approved Pharma Inhibition, Inhibitor, Target, inhibitor Bone resorption inhibitor, Osteoclast function modifiers (important in bone metastasis) 162
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(4) Additional Compounds for PTPRS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PTPRS: view

Transcripts for PTPRS Gene

Unigene Clusters for PTPRS Gene

Protein tyrosine phosphatase, receptor type, S:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - - - - -
SP2:
SP3:
SP4:

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1:
SP2:
SP3:
SP4:

Relevant External Links for PTPRS Gene

GeneLoc Exon Structure for
PTPRS
ECgene alternative splicing isoforms for
PTPRS

Expression for PTPRS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTPRS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPRS Gene

This gene is overexpressed in Cerebrospinal fluid (32.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPRS Gene



Protein tissue co-expression partners for PTPRS Gene

NURSA nuclear receptor signaling pathways regulating expression of PTPRS Gene:

PTPRS

SOURCE GeneReport for Unigene cluster for PTPRS Gene:

Hs.744928

mRNA Expression by UniProt/SwissProt for PTPRS Gene:

Q13332-PTPRS_HUMAN
Tissue specificity: Detected in peripheral blood plasmacytoid dendritic cells (at protein level) (PubMed:26231120). Detected in all tissues tested except for placenta and liver (PubMed:8524829, PubMed:8992885). Detected in peripheral blood plasmacytoid dendritic cells (PubMed:26231120).

Evidence on tissue expression from TISSUES for PTPRS Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with PTPRS: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRS Gene

Orthologs for PTPRS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPRS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRS 34 35
  • 99.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRS 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRS 34 35
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Ptprs 34 16 35
  • 86.42 (n)
rat
(Rattus norvegicus)
Mammalia Ptprs 34
  • 86.17 (n)
dog
(Canis familiaris)
Mammalia PTPRS 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRS 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRS 35
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ptprsb 35
  • 91 (a)
OneToMany
ptprsa 34 35
  • 71.6 (n)
ptprs 34
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 36
  • 41 (a)
Lar 36 35
  • 39 (a)
Ptp69D 36
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea Y48G9A.9 36
  • 36 (a)
F55F8.7 36
  • 35 (a)
K04D7.4 36
  • 35 (a)
F25H5.7 36
  • 34 (a)
T22C1.8 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTP1 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1998 35
  • 45 (a)
OneToMany
Species where no ortholog for PTPRS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPRS Gene

ENSEMBL:
Gene Tree for PTPRS (if available)
TreeFam:
Gene Tree for PTPRS (if available)

Paralogs for PTPRS Gene

Paralogs for PTPRS Gene

genes like me logo Genes that share paralogs with PTPRS: view

Variants for PTPRS Gene

Sequence variations from dbSNP and Humsavar for PTPRS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs775778266 A colorectal cancer sample 5,222,805(+) GCAGC(A/G)TGAGC intron-variant, reference, missense
rs1000017169 -- 5,302,590(+) AAGAG(A/G)TTGGC intron-variant
rs1000020878 -- 5,216,690(+) GCGAA(A/T)GGAAG intron-variant
rs1000026082 -- 5,226,145(+) AGAGG(A/G)CGCCT intron-variant
rs1000030687 -- 5,308,903(+) TGCTC(C/G)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRS Gene

Variant ID Type Subtype PubMed ID
esv1006709 CNV loss 20482838
esv22199 CNV loss 19812545
esv2667935 CNV deletion 23128226
esv2718041 CNV deletion 23290073
esv2718042 CNV deletion 23290073
esv3574286 CNV gain 25503493
nsv1055783 CNV gain 25217958
nsv1072308 CNV deletion 25765185
nsv1077335 CNV duplication 25765185
nsv1113963 CNV deletion 24896259
nsv1118807 CNV deletion 24896259
nsv1118808 CNV deletion 24896259
nsv1123211 CNV deletion 24896259
nsv510750 CNV deletion 20534489
nsv833723 CNV loss 17160897
nsv833724 CNV loss 17160897
nsv953951 CNV deletion 24416366
nsv962995 CNV duplication 23825009

Variation tolerance for PTPRS Gene

Residual Variation Intolerance Score: 0.361% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRS Gene

Human Gene Mutation Database (HGMD)
PTPRS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPRS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRS Gene

Disorders for PTPRS Gene

MalaCards: The human disease database

(5) MalaCards diseases for PTPRS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pineal gland cancer
  • malignant pineal region tumor
ureterocele
deafness, autosomal recessive 68
  • autosomal recessive nonsyndromic deafness 68
deafness, autosomal recessive 15
  • autosomal recessive nonsyndromic deafness 15
malignant ependymoma
  • ependymal neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search PTPRS in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPRS

Genetic Association Database (GAD)
PTPRS
Human Genome Epidemiology (HuGE) Navigator
PTPRS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRS
genes like me logo Genes that share disorders with PTPRS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRS Gene

Publications for PTPRS Gene

  1. Genetic variation in receptor protein tyrosine phosphatase sigma is associated with type 2 diabetes in Swedish Caucasians. (PMID: 17893260) LAYngberg E.C. … Ostenson C.G. (Eur. J. Endocrinol. 2007) 3 22 46 64
  2. Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3. (PMID: 8954782) Wagner J. … Olsen A.S. (Genomics 1996) 2 3 22 64
  3. Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. (PMID: 8992885) Endo N. … Schmidt A. (J. Bone Miner. Res. 1996) 3 4 22 64
  4. The LAR/PTP delta/PTP sigma subfamily of transmembrane protein- tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. (PMID: 8524829) Pulido R. … Streuli M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 64
  5. Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells. (PMID: 26231120) Bunin A. … Reizis B. (Immunity 2015) 3 4 64

Products for PTPRS Gene

Sources for PTPRS Gene

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