Aliases for PTPRS Gene
External Ids for PTPRS Gene
Previous GeneCards Identifiers for PTPRS Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPRS Gene
PTPRS (Protein Tyrosine Phosphatase, Receptor Type S) is a Protein Coding gene. Diseases associated with PTPRS include pineal gland cancer and ureterocele. Among its related pathways are Degradation of the extracellular matrix and Transmission across Chemical Synapses. GO annotations related to this gene include phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRK.
UniProtKB/Swiss-Prot for PTPRS Gene
Interacts with LAR-interacting protein LIP.1.