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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPRS Gene

protein-coding   GIFtS: 66
GCID: GC19M005157

protein tyrosine phosphatase, receptor type, S
 Explore 16 diseases affiliated with
PTPRS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PTPRS    

Aliases
for PTPRS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Tyrosine Phosphatase, Receptor Type, S1 2     PTPSIGMA2
Receptor-Type Tyrosine-Protein Phosphatase Sigma2 3     Protein Tyrosine Phosphatase PTPsigma2
R-PTP-S2 3     Protein Tyrosine Phosphatase, Receptor Type, Sigma2
R-PTP-Sigma1     Receptor-Type Tyrosine-Protein Phosphatase S2
EC 3.1.3.483 8     

External Ids:    HGNC: 96811   Entrez Gene: 58022   Ensembl: ENSG000001054267   OMIM: 6015765   UniProtKB: Q133323   

Export aliases for PTPRS gene to outside databases

Previous GC identifers: GC19M005298 GC19M005146 GC19M004967


Summaries
for PTPRS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PTPRS:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic
cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two
tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this
protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice
suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during
embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively
spliced transcript variants, which encode distinct proteins, have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PTPRS_HUMAN, Q13332
Function: Interacts with LAR-interacting protein LIP.1

Gene Wiki entry for PTPRS


Genomic Views
for PTPRS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPRS gene promoter:
         MAZR   GCNF   LCR-F1   HNF-4alpha1   E2F-1   E2F   NRF-2   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTPRS promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPRS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPRS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PTPRS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRS gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M005157:  view genomic region     (about GC identifiers)

Start:
 5,158,506 bp from pter      End:
 5,340,814 bp from pter
Size:
 182,309 bases      Orientation:
 minus strand

Proteins
for PTPRS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PTPRS_HUMAN, Q13332 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein phosphatase S precursor  
Size: 1948 amino acids; 217041 Da
Subunit: Interacts with PPFIA1, PPFIA2 and PPFIA3
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAC50567.1; Type=Frameshift; Positions=Several;
4 PDB 3D structures from and Proteopedia for PTPRS:
2FH7 (3D)        2YD2 (3D)        2YD3 (3D)        2YD9 (3D)    
Secondary accessions: O75255 O75870 Q15718 Q16341 Q2M3R7
Alternative splicing: 7 isoforms:  Q13332-1   Q13332-2   Q13332-3   Q13332-4   Q13332-5   Q13332-6   Q13332-7   

Explore the universe of human proteins at neXtProt for PTPRS: NX_Q13332

Post-translational modifications:

  • A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain
    • shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By
    similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13332

    • 4/58 DME Specific Peptides for PTPRS (Q13332) (see all 58)
     AVGSPMP  KCHQYWP  WPDHGVP  DPVEMRR 

    PTPRS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_002841.3  NP_570923.2  NP_570924.2  NP_570925.2  

    ENSEMBL proteins: 
     ENSP00000467537   ENSP00000467398   ENSP00000465443   ENSP00000465185   ENSP00000468803  
     ENSP00000468455   ENSP00000361489   ENSP00000349932   ENSP00000262963   ENSP00000269907  
     ENSP00000327313  

    Human Recombinant Protein Products: 
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    Novus Biologicals PTPRS Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PTPRS

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS8524829


    PTPRS for ontologies           About GeneDecksing



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    Uscn Antibodies for PTPRS
    ThermoFisher Antibodies for PTPRS

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    Uscn ELISAs and CLIAs for PTPRS

    Protein Domains /
    Families
    for PTPRS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTPRS for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR003598 Ig_sub2
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR016130 Tyr_Pase_AS
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q13332

    ProtoNet protein and cluster: Q13332

    5 Blocks protein families:
    IPB000242 Protein tyrosine phosphatase signature
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB003962 Fibronectin type III repeat signature
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: PTPRS_HUMAN, Q13332
    Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily
    Similarity: Contains 8 fibronectin type-III domains
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 tyrosine-protein phosphatase domains


    Function
    for PTPRS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PTPRS_HUMAN, Q13332
    Function: Interacts with LAR-interacting protein LIP.1
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPRS:
    protein tyrosine phosphatase,receptor-type sigma,putatively involved in the development of the nervous system

    Enzyme Number (IUBMB): EC 3.1.3.481 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPRS
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    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-139-5p hsa-miR-374c hsa-miR-511 hsa-miR-141* hsa-miR-3121-3p hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmid: PTPRS 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPRS (see all 7)
    OriGene shRNA RFP: PTPRS
    OriGene siRNA: PTPRS
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0005001transmembrane receptor protein tyrosine phosphatase activity TAS8524829
    GO:0005515protein binding IPI16273344


    PTPRS for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for PTPRS:
     Apoptosis resistance  Decreased focal adhesion (FA)   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Ptprstm1Mtr for PTPRS
         15/18 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ptprs) (see all 18):
     adipose tissue  behavior/neurological  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  integument  mortality/aging 
     muscle  nervous system  renal/urinary system  reproductive system  respiratory system 

    PTPRS for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PTPRS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PAK Pathway
    		Epithelial Adherens Junctions0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPRS
        Epithelial Adherens Junctions


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPRS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/32 Interacting proteins for PTPRS (Q133321, 2, 3 ENSP000003499324) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRNQ168491, 3, ENSP000002957184EBI-1058503,EBI-728153 I2D: score=2 STRING: ENSP00000295718
    EIF4A2Q142403, ENSP000003263814I2D: score=2 STRING: ENSP00000326381
    PPFIA3O751453, ENSP000003356144I2D: score=2 STRING: ENSP00000335614
    PTPRDP234683, ENSP000003488124I2D: score=2 STRING: ENSP00000348812
    PTPREP234693, ENSP000002546674I2D: score=1 STRING: ENSP00000254667
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0021510spinal cord development IEA--
    GO:0021549cerebellum development IEA--
    GO:0021766hippocampus development IEA--
    GO:0021987cerebral cortex development IEA--


    PTPRS for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTPRS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTPRS for compounds           About GeneDecksing

    EMD Millipore small molecules for PTPRS:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPRS

    1 HMDB Compound for PTPRS    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    2 DrugBank Compounds for PTPRS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AlendronateAcide Alendronique [INN-French] (see all 5)66376-36-1targetinhibitor9310349 11752352 8610169
    Etidronic acidAcetodiphosphonic acid (see all 11)7414-83-7targetinhibitor11752352 8610169

    4 Novoseek chemical compound relationships for PTPRS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 74.1 72 17178832 (3), 17893260 (2), 8954782 (2), 10648238 (2) (see all 51)
    alpha-latrotoxin 62.7 4 16552719 (2), 12110683 (1)
    phosphotyrosine 44.9 2 15588988 (1), 12456340 (1)
    heparan sulfate 21.9 1 16995858 (1)

    Search CenterWatch for drugs/clinical trials and news about PTPRS 

    Transcripts
    for PTPRS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTPRS gene (4 alternative transcripts): 
    NM_002850.3  NM_130853.2  NM_130854.2  NM_130855.2  

    Unigene Cluster for PTPRS:

    Protein tyrosine phosphatase, receptor type, S
    Hs.644384  [show with all ESTs]
    Unigene Representative Sequence: NM_002850
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588552 ENST00000587303 ENST00000592099 ENST00000588012 ENST00000589851
    ENST00000590509 ENST00000591760 ENST00000586065 ENST00000372412 ENST00000357368(uc002mbu.1 uc002mbv.3 uc002mbx.3)
    ENST00000262963 ENST00000348075(uc002mbw.3) ENST00000353284(uc010xin.2 uc002mby.3 uc002mbz.1)


    miRNA
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    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-139-5p hsa-miR-374c hsa-miR-511 hsa-miR-141* hsa-miR-3121-3p hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmid: PTPRS 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB209333.1 BC029496.1 BC104812.1 BC143286.1 BC143287.1 BC148297.2 S78080.1 S78086.1 
    U35234.1 U40317.1 U41725.1 

    14 DOTS entries:

    DT.414255  DT.100774465  DT.100765222  DT.95267800  DT.100036237  DT.95232060  DT.99933956  DT.100667947 
    DT.100774463  DT.95227053  DT.100022656  DT.95238863  DT.95267802  DT.121459866 

    24/189 AceView cDNA sequences (see all 189):

    AA676967 BI027941 AA640162 CD636153 CD636151 BF836096 CD636155 CD674329 
    BI027940 BQ722643 BX282294 BU855303 AU123663 BX460268 AI991971 BE071939 
    BQ028993 BU620083 CB851752 BX452002 CD636141 CD636144 BE071979 U40317 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PTPRS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                          -                                         -     -     -     -                                                                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          


    ECgene alternative splicing isoforms for PTPRS

    Expression
    for PTPRS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPRS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGGAGCTCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PTPRS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PTPRS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPRS

    SOURCE GeneReport for Unigene cluster: Hs.644384

    UniProtKB/Swiss-Prot: PTPRS_HUMAN, Q13332
    Tissue specificity: Detected in all tissues tested except for placenta and liver

        SABiosciences Expression via Pathway-Focused PCR Array including PTPRS: 
              Protein Phosphatases in human mouse rat

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    In Situ
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    Orthologs
    for PTPRS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PTPRS gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves Q90817_CHICK6
    		 protein-tyrosine phosphatase CRYPalpha
    		 87(a)
    		 1 ↔ 1
    		 28(4196929-4290015)
    lizard
    (Anolis carolinensis)    		 Reptilia PTPRS6
    --
    		 --
    		 76(a)
    36(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343852.1(21494-150610)
    GL343358.1(365807-375201)
    zebrafish
    (Danio rerio)    		 Actinopterygii ptprs2 protein tyrosine phosphatase, receptor type, S 80.38(n)   140820  AJ311886.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ptp52F3 axon guidance protein tyrosine phosphatase 41(a)
    (best of 3)    		   52F3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y48G9A.93   -- 36(a)
    (best of 5)    		   III(2164580-2171451)   --


    ENSEMBL Gene Tree for PTPRS (if available)
    TreeFam Gene Tree for PTPRS (if available) 

    Paralogs
    for PTPRS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPRS gene
    PTPRK2  PTPRC2  PTPRA2  PTPRG2  PTPRD2  PTPRF2  PTPRM2  PTPRU2  
    PTPRZ12  PTPRT2  PTPRE2  
    18/61 SIMAP similar genes for PTPRS using alignment to 11 protein entries:     PTPRS_HUMAN (see all proteins) (see all similar genes):
    BPTP-2    PTPsigma    DKFZp686B1310    PTPRF    PTPRD    DKFZp313F1310
    DKFZp781C1038    L1CAM    PTPRK    PTPRA    DKFZp686C2268    PTPRG
    PTPN5    PTPRT    PTPRR    PTPRU    PTPN13    PTPRQ

    PTPRS for paralogs           About GeneDecksing



    Genomic Variants
    for PTPRS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2829 NCBI SNPs in PTPRS are shown (see all 2829)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs561949651,2
    		C--5029574(+) TTAATT/AAATTA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs577781631,2
    		C,--5205074(+) TGTTT-/TGAGTTT 4 -- ds50010--------
    rs1473490301,2
    		--5205356(+) TCAGCA/GGTGTG 4 -- ds50010--------
    rs756455191,2
    		--5205409(+) CTCTGA/GCTGTT 4 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1849587651,2
    		--5205490(+) AGGGGC/TGCAAC 4 -- ds50010--------
    rs1898130991,2
    		--5205582(+) CCACCC/TGGCTG 4 -- ut310--------
    rs1823728511,2
    		--5205585(+) CCCGGC/TTGCTT 4 -- ut310--------
    rs128401,2
    		C,F,H,--5205626(-) GGCAGG/ATCTGC 4 -- ut3111Minor allele frequency- A:0.04MN NS EA NA WA 922
    rs570216471,2
    		C,F,--5205658(+) CGCTTG/CCTCAG 4 -- ut315Minor allele frequency- C:0.14NA WA 244
    rs43463091,2
    		C,F,A,--5205688(+) GCCTGT/ACCTTC 4 -- ut315Minor allele frequency- A:0.08NA CSA EA 246

    HapMap Linkage Disequilibrium report for PTPRS (5158506 - 5340814 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PTPRS
         1 Indel: 73300

    2 SABiosciences Cancer Mutation PCR Assays for PTPRS:
    Cosmic IdAA Change
    33665p.T996M
    117687p.T996A
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPRS
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPRS

    Disorders / Diseases
    for PTPRS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTPRS for disorders           About GeneDecksing

    OMIM gene information: 601576    OMIM disorders: --

    16 diseases for PTPRS:    About MalaCards
    spinal cord injury    chordoid glioma    corpus callosum    ureterocele
    pituitary hypoplasia    papillary thyroid carcinoma    ulcerative colitis    thyroid carcinoma
    thyroiditis    prostate carcinoma    carcinoma    breast cancer
    cerebritis    retinitis    prostatitis    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for PTPRS:
    Pineal gland cancer     Ureterocele     Chordoid glioma

    1 Novoseek disease relationship for PTPRS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 12538453 (1)

    Human Genome Epidemiology (HuGE) Navigator: PTPRS (2 documents)

    Export disorders for PTPRS gene to outside databases

    Publications
    for PTPRS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPRS gene, integrated from 9 sources (see all 115):
    (articles sorted by number of sources associating them with PTPRS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. (PubMed id 8524829)1, 2, 3 Pulido R....Streuli M. (1995)
    2. Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3. (PubMed id 8954782)1, 3, 9 Wagner J....Olsen A.S. (1996)
    3. Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. (PubMed id 8992885)1, 2, 9 Endo N.... Schmidt A. (1996)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins. (PubMed id 9624153)1, 2 Serra-Pages C.... Streuli M. (1998)
    7. Protein-tyrosine phosphatase expression in pre-B cell NALM-6. (PubMed id 1370651)1, 2 Adachi M.... Yachi A. (1992)
    8. The transmembrane protein tyrosine phosphatase RPTPsigma modulates signaling of the epidermal growth factor receptor in A431 cells. (PubMed id 10435588)1, 9 Suarez Pestana E....Bohmer F.D. (1999)
    9. A new role for RPTPsigma in spinal cord injury: signa ling chondroitin sulfate proteoglycan inhibition. (PubMed id 20179269)1, 9 Duan Y. and Giger R.J. (2010)
    10. Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases. (PubMed id 12376545)1, 9 Blanchetot C....den Hertog J. (2002)

    External Searches for PTPRS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTPRS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5802 HGNC: 9681 AceView: PTPRS Ensembl:ENSG00000105426 euGenes: HUgn5802
    ECgene: PTPRS H-InvDB: PTPRS

    Other Databases showing PTPRS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTPRS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPRS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPRS Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PTPRS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTPRS gene:
    Search GeneIP for patents involving PTPRS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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