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Aliases for PTPRS Gene

Aliases for PTPRS Gene

  • Protein Tyrosine Phosphatase, Receptor Type S 2 3
  • Receptor-Type Tyrosine-Protein Phosphatase Sigma 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, S 3 5
  • R-PTP-Sigma 3 4
  • EC 4 63
  • R-PTP-S 3 4
  • Protein Tyrosine Phosphatase PTPsigma 3

External Ids for PTPRS Gene

Previous GeneCards Identifiers for PTPRS Gene

  • GC19M005298
  • GC19M005146
  • GC19M004967

Summaries for PTPRS Gene

Entrez Gene Summary for PTPRS Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRS Gene

PTPRS (Protein Tyrosine Phosphatase, Receptor Type S) is a Protein Coding gene. Diseases associated with PTPRS include Pineal Gland Cancer and Ureterocele. Among its related pathways are Transmission across Chemical Synapses and Degradation of the extracellular matrix. GO annotations related to this gene include phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRK.

UniProtKB/Swiss-Prot for PTPRS Gene

  • Interacts with LAR-interacting protein LIP.1.

Gene Wiki entry for PTPRS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRS Gene

Genomics for PTPRS Gene

Regulatory Elements for PTPRS Gene

Enhancers for PTPRS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTPRS on UCSC Golden Path with GeneCards custom track

Promoters for PTPRS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTPRS on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPRS Gene

5,158,495 bp from pter
5,340,803 bp from pter
182,309 bases
Minus strand

Genomic View for PTPRS Gene

Genes around PTPRS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRS Gene

Proteins for PTPRS Gene

  • Protein details for PTPRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-type tyrosine-protein phosphatase S
    Protein Accession:
    Secondary Accessions:
    • O75255
    • O75870
    • Q15718
    • Q16341
    • Q2M3R7

    Protein attributes for PTPRS Gene

    1948 amino acids
    Molecular mass:
    217041 Da
    Quaternary structure:
    • Interacts with PPFIA1, PPFIA2 and PPFIA3.
    • Sequence=AAC50567.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRS Gene

    Alternative splice isoforms for PTPRS Gene

neXtProt entry for PTPRS Gene

Proteomics data for PTPRS Gene at MOPED

Post-translational modifications for PTPRS Gene

  • A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called ectodomain shedding is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).
  • Glycosylation at Asn 263, Asn 308, Asn 733, and Asn 940
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PTPRS (PTP sigma/PTPRS)

Domains & Families for PTPRS Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
  • Contains 8 fibronectin type-III domains.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 tyrosine-protein phosphatase domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
genes like me logo Genes that share domains with PTPRS: view

Function for PTPRS Gene

Molecular function for PTPRS Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type sigma,putatively involved in the development of the nervous system
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Interacts with LAR-interacting protein LIP.1.

Enzyme Numbers (IUBMB) for PTPRS Gene

genes like me logo Genes that share phenotypes with PTPRS: view

Animal Models for PTPRS Gene

MGI Knock Outs for PTPRS:

Animal Model Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRS Gene

Localization for PTPRS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRS Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PTPRS Gene COMPARTMENTS Subcellular localization image for PTPRS gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 2
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PTPRS Gene

Pathways & Interactions for PTPRS Gene

genes like me logo Genes that share pathways with PTPRS: view

Pathways by source for PTPRS Gene

SIGNOR curated interactions for PTPRS Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PTPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0021549 cerebellum development IEA --
GO:0021766 hippocampus development IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with PTPRS: view

Drugs & Compounds for PTPRS Gene

(3) Drugs for PTPRS Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Etidronic acid Approved Pharma Target, inhibitor 83
Alendronate Approved Pharma Inhibition, Inhibitor, Target, inhibitor Bone resorption inhibitor, Osteoclast function modifiers (important in bone metastasis) 157

(6) Additional Compounds for PTPRS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with PTPRS: view

Transcripts for PTPRS Gene

Unigene Clusters for PTPRS Gene

Protein tyrosine phosphatase, receptor type, S:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - - - - -

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32

Relevant External Links for PTPRS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPRS Gene

mRNA expression in normal human tissues for PTPRS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPRS Gene

This gene is overexpressed in Cerebrospinal fluid (32.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRS Gene

SOURCE GeneReport for Unigene cluster for PTPRS Gene Hs.744928

mRNA Expression by UniProt/SwissProt for PTPRS Gene

Tissue specificity: Detected in all tissues tested except for placenta and liver.
genes like me logo Genes that share expression patterns with PTPRS: view

Protein tissue co-expression partners for PTPRS Gene

Primer Products

No data available for mRNA differential expression in normal tissues for PTPRS Gene

Orthologs for PTPRS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPRS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PTPRS 35
  • 91.41 (n)
  • 96.97 (a)
  • 97 (a)
(Mus musculus)
Mammalia Ptprs 35
  • 86.42 (n)
  • 94.23 (a)
Ptprs 16
Ptprs 36
  • 94 (a)
(Pan troglodytes)
Mammalia PTPRS 35
  • 99.38 (n)
  • 99.79 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ptprs 35
  • 86.17 (n)
  • 93.72 (a)
(Canis familiaris)
Mammalia PTPRS 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia PTPRS 36
  • 92 (a)
(Gallus gallus)
Aves PTPRS 36
  • 90 (a)
(Anolis carolinensis)
Reptilia PTPRS 36
  • 76 (a)
(Danio rerio)
Actinopterygii ptprs 35
ptprsa 35
  • 71.6 (n)
  • 74 (a)
ptprsa 36
  • 73 (a)
ptprsb 36
  • 91 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lar 37
  • 39 (a)
Ptp52F 37
  • 41 (a)
Ptp69D 37
  • 35 (a)
Lar 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea F25H5.7 37
  • 34 (a)
F55F8.7 37
  • 35 (a)
K04D7.4 37
  • 35 (a)
T22C1.8 37
  • 33 (a)
Y48G9A.9 37
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTP1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1998 36
  • 45 (a)
Species with no ortholog for PTPRS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPRS Gene

Gene Tree for PTPRS (if available)
Gene Tree for PTPRS (if available)

Paralogs for PTPRS Gene

Paralogs for PTPRS Gene

genes like me logo Genes that share paralogs with PTPRS: view

Variants for PTPRS Gene

Sequence variations from dbSNP and Humsavar for PTPRS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035649 A colorectal cancer sample
rs4807697 - 5,214,686(+) CTGAC(A/G)CCGGT reference, missense
rs758512 -- 5,290,873(+) GGCCT(C/G)CAGCC intron-variant
rs758513 -- 5,291,399(+) CCCAG(A/G)GTCCA intron-variant
rs758514 -- 5,272,050(+) aaatt(A/G)cagct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRS Gene

Variant ID Type Subtype PubMed ID
nsv910875 CNV Loss 21882294
nsv833723 CNV Loss 17160897
nsv510750 CNV Loss 20534489
dgv3689n71 CNV Loss 21882294
dgv3690n71 CNV Loss 21882294
dgv3691n71 CNV Loss 21882294
esv1006709 CNV Loss 20482838
nsv833724 CNV Loss 17160897
nsv910890 CNV Loss 21882294
esv22199 CNV Loss 19812545
esv2718041 CNV Deletion 23290073
esv2718042 CNV Deletion 23290073
esv2667935 CNV Deletion 23128226

Variation tolerance for PTPRS Gene

Residual Variation Intolerance Score: 0.361% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRS Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRS Gene

Disorders for PTPRS Gene

MalaCards: The human disease database

(4) MalaCards diseases for PTPRS Gene - From: DISEASES

Disorder Aliases PubMed IDs
pineal gland cancer
  • malignant pineal region tumor
malignant ependymoma
  • ependymal neoplasm
  • pineal pnet
- elite association - COSMIC cancer census association via MalaCards
Search PTPRS in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPRS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PTPRS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRS Gene

Publications for PTPRS Gene

  1. The LAR/PTP delta/PTP sigma subfamily of transmembrane protein- tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. (PMID: 8524829) Pulido R. … Streuli M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 67
  2. Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3. (PMID: 8954782) Wagner J. … Olsen A.S. (Genomics 1996) 2 3 23
  3. A new role for RPTPsigma in spinal cord injury: signaling chondroitin sulfate proteoglycan inhibition. (PMID: 20179269) Duan Y. … Giger R.J. (Sci Signal 2010) 3 23
  4. Protein-tyrosine phosphatase sigma is associated with ulcerative colitis. (PMID: 17614280) Muise A.M. … Rotin D. (Curr. Biol. 2007) 3 23
  5. Genetic variation in receptor protein tyrosine phosphatase sigma is associated with type 2 diabetes in Swedish Caucasians. (PMID: 17893260) LAYngberg E.C. … Ostenson C.G. (Eur. J. Endocrinol. 2007) 3 23

Products for PTPRS Gene

Sources for PTPRS Gene