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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPRS Gene

protein-coding   GIFtS: 71
GCID: GC19M005157

Protein Tyrosine Phosphatase, Receptor Type, S

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Receptor Type, S1 2     PTPSIGMA2
Receptor-Type Tyrosine-Protein Phosphatase Sigma2 3     Protein Tyrosine Phosphatase PTPsigma2
R-PTP-S2 3     Protein Tyrosine Phosphatase, Receptor Type, Sigma2
R-PTP-sigma2 3     Receptor-Type Tyrosine-Protein Phosphatase S2
EC 3.1.3.483 8     

External Ids:    HGNC: 96811   Entrez Gene: 58022   Ensembl: ENSG000001054267   OMIM: 6015765   UniProtKB: Q133323   

Export aliases for PTPRS gene to outside databases

Previous GC identifers: GC19M005298 GC19M005146 GC19M004967


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPRS Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane
segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The
extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains.
Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary
axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control
of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been
reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTPRS Gene: 
PTPRS (protein tyrosine phosphatase, receptor type, S) is a protein-coding gene. Diseases associated with PTPRS include pineal gland cancer, and ureterocele, and among its related super-pathways are Collagen formation and ECM-receptor interaction. GO annotations related to this gene include protein binding and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRK.

UniProtKB/Swiss-Prot: PTPRS_HUMAN, Q13332
Function: Interacts with LAR-interacting protein LIP.1

Gene Wiki entry for PTPRS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPRS gene promoter:
         MAZR   GCNF   LCR-F1   HNF-4alpha1   E2F-1   E2F   NRF-2   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPRS promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPRS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPRS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PTPRS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRS gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M005157:  view genomic region     (about GC identifiers)

Start:
5,158,506 bp from pter      End:
5,340,814 bp from pter
Size:
182,309 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTPRS_HUMAN, Q13332 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein phosphatase S precursor  
Size: 1948 amino acids; 217041 Da
Subunit: Interacts with PPFIA1, PPFIA2 and PPFIA3
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAC50567.1; Type=Frameshift; Positions=Several;
4 PDB 3D structures from and Proteopedia for PTPRS:
2FH7 (3D)        2YD2 (3D)        2YD3 (3D)        2YD9 (3D)    
Secondary accessions: O75255 O75870 Q15718 Q16341 Q2M3R7
Alternative splicing: 7 isoforms:  Q13332-1   Q13332-2   Q13332-3   Q13332-4   Q13332-5   Q13332-6   Q13332-7   

Explore the universe of human proteins at neXtProt for PTPRS: NX_Q13332

Explore proteomics data for PTPRS at MOPED 

Post-translational modifications:

  • UniProtKB: A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called
    'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane
    localization (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13332

  • 4/58 DME Specific Peptides for PTPRS (Q13332) (see all 58)
     AVGSPMP  KCHQYWP  WPDHGVP  DPVEMRR 

    PTPRS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTPRS Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_002841.3  NP_570923.2  NP_570924.2  NP_570925.2  

    ENSEMBL proteins: 
     ENSP00000467537   ENSP00000467398   ENSP00000465443   ENSP00000465185   ENSP00000468803  
     ENSP00000468455   ENSP00000361489   ENSP00000349932   ENSP00000262963   ENSP00000269907  
     ENSP00000327313  
    Reactome Protein details: Q13332
    Human Recombinant Protein Products for PTPRS: 
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    R&D Systems Recombinant & Natural Proteins for PTPRS (PTPR sigma)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PTPRS
    OriGene Protein Over-expression Lysate for PTPRS
    OriGene MassSpec for PTPRS 
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    GenScript Custom Purified and Recombinant Proteins Services for PTPRS
    Novus Biologicals PTPRS Protein
    Novus Biologicals PTPRS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTPRS 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS8524829

    PTPRS for ontologies           About GeneDecksing



    PTPRS Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for PTPRS 

    Assay Products for PTPRS: 
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    GenScript Custom Assay Services for PTPRS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTPRS 
    Cloud-Clone Corp. CLIAs for PTPRS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    PTPR: Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like

    IUPHAR Guide to PHARMACOLOGY protein family classification: Type S 
    Receptor tyrosine phosphatases (RTP)

    5/8 InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR016130 Tyr_Pase_AS
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q13332

    ProtoNet protein and cluster: Q13332

    5 Blocks protein domains:
    IPB000242 Protein tyrosine phosphatase signature
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB003962 Fibronectin type III repeat signature
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: PTPRS_HUMAN, Q13332
    Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily
    Similarity: Contains 8 fibronectin type-III domains
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 tyrosine-protein phosphatase domains


    PTPRS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTPRS_HUMAN, Q13332
    Function: Interacts with LAR-interacting protein LIP.1
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPRS:
    protein tyrosine phosphatase,receptor-type sigma,putatively involved in the development of the nervous system

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0005001transmembrane receptor protein tyrosine phosphatase activity TAS8524829
    GO:0005515protein binding IPI16273344
    GO:0016791phosphatase activity ----
         
    PTPRS for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PTPRS:
     Apoptosis resistance  Decreased focal adhesion (FA)   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Upregulation of Wnt/beta-caten 

         15/18 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptprs) (see all 18):
     adipose tissue  behavior/neurological  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  integument  mortality/aging 
     muscle  nervous system  renal/urinary system  reproductive system  respiratory system 

    PTPRS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptprstm1Mtr for PTPRS

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTPRS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTPRS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPRS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPRS 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPRS
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPRS (see all 23):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-139-5p hsa-miR-374c hsa-miR-511 hsa-miR-141* hsa-miR-3121-3p hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidPTPRS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTPRS
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PTPRS

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): PTPRS (NM_002850)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTPRS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Extracellular matrix organization0.39
    2Non-integrin membrane-ECM interactions
    ECM proteoglycans0.38
    3PAK Pathway
    Epithelial Adherens Junctions0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPRS
        Epithelial Adherens Junctions

    2        Reactome Pathways for PTPRS
        ECM proteoglycans
    Extracellular matrix organization



    PTPRS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPRS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/32 Interacting proteins for PTPRS (Q133321, 2, 3 ENSP000003499324) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRNQ168491, 3, ENSP000002957184EBI-711536,EBI-728153 I2D: score=2 STRING: ENSP00000295718
    EIF4A2Q142403, ENSP000003263814I2D: score=2 STRING: ENSP00000326381
    PPFIA3O751453, ENSP000003356144I2D: score=2 STRING: ENSP00000335614
    PTPRDP234683, ENSP000003488124I2D: score=2 STRING: ENSP00000348812
    PTPREP234693, ENSP000002546674I2D: score=1 STRING: ENSP00000254667
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation ----
    GO:0007155cell adhesion IEA--
    GO:0016311dephosphorylation ----
    GO:0021510spinal cord development IEA--
    GO:0021549cerebellum development IEA--

    PTPRS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTPRS for compounds           About GeneDecksing

    EMD Millipore small molecules for PTPRS:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPRS

    1 HMDB Compound for PTPRS    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    2 DrugBank Compounds for PTPRS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AlendronateAcide Alendronique [INN-French] (see all 5)66376-36-1targetinhibitor9310349 11752352 8610169
    Etidronic acidAcetodiphosphonic acid (see all 11)7414-83-7targetinhibitor11752352 8610169

    4 Novoseek inferred chemical compound relationships for PTPRS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 74.1 72 17178832 (3), 17893260 (2), 8954782 (2), 10648238 (2) (see all 51)
    alpha-latrotoxin 62.7 4 16552719 (2), 12110683 (1)
    phosphotyrosine 44.9 2 15588988 (1), 12456340 (1)
    heparan sulfate 21.9 1 16995858 (1)

    Search CenterWatch for drugs/clinical trials and news about PTPRS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTPRS gene (4 alternative transcripts): 
    NM_002850.3  NM_130853.2  NM_130854.2  NM_130855.2  

    Unigene Cluster for PTPRS:

    Protein tyrosine phosphatase, receptor type, S
    Hs.744928  [show with all ESTs]
    Unigene Representative Sequence: NM_002850
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588552 ENST00000587303 ENST00000592099 ENST00000588012 ENST00000589851
    ENST00000590509 ENST00000591760 ENST00000586065 ENST00000372412 ENST00000357368(uc002mbu.1 uc002mbv.3 uc002mbx.3)
    ENST00000262963 ENST00000348075(uc002mbw.3) ENST00000353284(uc010xin.2 uc002mby.3 uc002mbz.1)

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPRS (see all 23):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-139-5p hsa-miR-374c hsa-miR-511 hsa-miR-141* hsa-miR-3121-3p hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidPTPRS 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209333.1 BC029496.1 BC104812.1 BC143286.1 BC143287.1 BC148297.2 S78080.1 S78086.1 
    U35234.1 U40317.1 U41725.1 

    14 DOTS entries:

    DT.414255  DT.100774465  DT.100765222  DT.95267800  DT.95232060  DT.99933956  DT.100036237  DT.100667947 
    DT.100774463  DT.95227053  DT.100022656  DT.95238863  DT.95267802  DT.121459866 

    24/189 AceView cDNA sequences (see all 189):

    AA676967 BI027941 AA640162 CD636153 CD636151 BF836096 BU855303 BX282294 
    BQ722643 CD674329 CD636155 BI027940 AU123663 AI991971 BX460268 BE071939 
    CB851752 BU620083 BQ028993 BX452002 CD636144 BE071979 CD636141 AI277876 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PTPRS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                          -                                         -     -     -     -                                                                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          


    ECgene alternative splicing isoforms for PTPRS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPRS expression in normal human tissues (normalized intensities)      PTPRS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGAGCTCG
    PTPRS Expression
    About this image


    PTPRS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             ganglion/cranial/facial VII   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Uterus (Reproductive System)
             endometrial endothelial cell   

    See PTPRS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPRS

    SOURCE GeneReport for Unigene cluster: Hs.744928

    UniProtKB/Swiss-Prot: PTPRS_HUMAN, Q13332
    Tissue specificity: Detected in all tissues tested except for placenta and liver

        SABiosciences Expression via Pathway-Focused PCR Array including PTPRS: 
              Protein Phosphatases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PTPRS gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptprs1 , 5 protein tyrosine phosphatase, receptor type, S1, 5 86.42(n)1
    94.23(a)1
      17 (29.32 cM)5
    192801  NM_011218.21  NP_035348.21 
     564124315 
    chicken
    (Gallus gallus)
    Aves PTPRS6
    receptor-type tyrosine-protein phosphatase delta p...
    90(a)
    1 ↔ 1
    28(4410520-4497158)
    lizard
    (Anolis carolinensis)
    Reptilia PTPRS6
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343852.1(21494-150610)
    zebrafish
    (Danio rerio)
    Actinopterygii ptprs2 protein tyrosine phosphatase, receptor type, S 80.38(n)   140820  AJ311886.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ptp52F3 axon guidance protein tyrosine
    phosphatase
    41(a)
    (best of 3)
      52F3   --


    ENSEMBL Gene Tree for PTPRS (if available)
    TreeFam Gene Tree for PTPRS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPRS gene
    PTPRK2  PTPRC2  PTPRA2  PTPRG2  PTPRD2  PTPRU2  PTPRF2  PTPRM2  
    PTPRZ12  PTPRT2  PTPRE2  
    18/62 SIMAP similar genes for PTPRS using alignment to 11 protein entries:     PTPRS_HUMAN (see all proteins) (see all similar genes):
    BPTP-2    PTPsigma    DKFZp686B1310    PTPRF    PTPRD    DKFZp313F1310
    DKFZp781C1038    L1CAM    PTPRK    PTPRA    DKFZp686C2268    PTPRG
    PTPN5    PTPRT    PTPRR    PTPRU    PTPN13    PTPRQ

    PTPRS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3587 SNPs in PTPRS are shown (see all 3587)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356494
    A colorectal cancer sample4--see VAR_0356492 T M mis40--------
    rs577781631,2
    C--5205074(+) TGTTT-/TGAGTTT 4 -- ds50010--------
    rs106741811,2
    C--5205078(+) ttttt-/TT/TTT
            
    ttttt
    8 -- ds5001 cds11NA 2
    rs1473490301,2
    --5205356(+) TCAGCA/GGTGTG 4 -- ds50010--------
    rs756455191,2
    F--5205409(+) CTCTGA/GCTGTT 4 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1849587651,2
    --5205490(+) AGGGGC/TGCAAC 4 -- ds50010--------
    rs1898130991,2
    --5205582(+) CCACCC/TGGCTG 4 -- ut310--------
    rs1823728511,2
    --5205585(+) CCCGGC/TTGCTT 4 -- ut310--------
    rs128401,2
    C,F,H--5205626(-) GGCAGG/ATCTGC 4 -- ut3111Minor allele frequency- A:0.04MN NS EA NA WA 922
    rs570216471,2
    C,F--5205658(+) CGCTTG/CCTCAG 4 -- ut315Minor allele frequency- C:0.14NA WA 244

    HapMap Linkage Disequilibrium report for PTPRS (5158506 - 5340814 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for PTPRS (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718042CNV Deletion23290073
    esv2667935CNV Deletion23128226
    esv2718041CNV Deletion23290073
    nsv910890CNV Loss21882294
    dgv3691n71CNV Loss21882294
    esv1006709CNV Loss20482838
    dgv3689n71CNV Loss21882294
    nsv833723CNV Loss17160897
    dgv3690n71CNV Loss21882294
    nsv833724CNV Loss17160897

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    117687p.T996A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601576    OMIM disorders: --

    13 diseases for PTPRS:    About MalaCards
    pineal gland cancer    ureterocele    chordoid glioma    pituitary hypoplasia
    spinal cord injury    papillary thyroid carcinoma    ulcerative colitis    thyroiditis
    retinitis    cerebritis    prostatitis    neuronitis
    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for PTPRS:
    Pineal gland cancer     Ureterocele     Chordoid glioma

    PTPRS for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PTPRS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 12538453 (1)

    Genetic Association Database (GAD): PTPRS
    Human Genome Epidemiology (HuGE) Navigator: PTPRS (2 documents)

    Export disorders for PTPRS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPRS gene, integrated from 9 sources (see all 116):
    (articles sorted by number of sources associating them with PTPRS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. (PubMed id 8524829)1, 2, 3 Pulido R....Streuli M. (1995)
    2. Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3. (PubMed id 8954782)1, 3, 9 Wagner J....Olsen A.S. (1996)
    3. Genetic variation in receptor protein tyrosine phosphatase sigma is associated with type 2 diabetes in Swedish Caucasians. (PubMed id 17893260)1, 4, 9 Langberg E.C....Ostenson C.G. (2007)
    4. Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. (PubMed id 8992885)1, 2, 9 Endo N.... Schmidt A. (1996)
    5. Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability. (PubMed id 19000305)1, 4 Korff S....Gebert J. (2008)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    8. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins. (PubMed id 9624153)1, 2 Serra-Pages C.... Streuli M. (1998)
    9. Protein-tyrosine phosphatase expression in pre-B cell NALM-6. (PubMed id 1370651)1, 2 Adachi M.... Yachi A. (1992)
    10. The transmembrane protein tyrosine phosphatase RPTPsigma modulates signaling of the epidermal growth factor receptor in A431 cells. (PubMed id 10435588)1, 9 Suarez Pestana E....Bohmer F.D. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5802 HGNC: 9681 AceView: PTPRS Ensembl:ENSG00000105426 euGenes: HUgn5802
    ECgene: PTPRS H-InvDB: PTPRS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPRS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPRS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTPRS gene:
    Search GeneIP for patents involving PTPRS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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