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Aliases for PTPRS Gene

Aliases for PTPRS Gene

  • Protein Tyrosine Phosphatase, Receptor Type, S 2 3
  • Receptor-Type Tyrosine-Protein Phosphatase Sigma 3 4
  • R-PTP-Sigma 3 4
  • EC 4 63
  • R-PTP-S 3 4
  • Receptor-Type Tyrosine-Protein Phosphatase S 3
  • Protein Tyrosine Phosphatase PTPsigma 3

External Ids for PTPRS Gene

Previous GeneCards Identifiers for PTPRS Gene

  • GC19M005298
  • GC19M005146
  • GC19M004967

Summaries for PTPRS Gene

Entrez Gene Summary for PTPRS Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRS Gene

PTPRS (Protein Tyrosine Phosphatase, Receptor Type, S) is a Protein Coding gene. Diseases associated with PTPRS include pineal gland cancer and ureterocele. Among its related pathways are PAK Pathway and Degradation of the extracellular matrix. GO annotations related to this gene include transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRT.

UniProtKB/Swiss-Prot for PTPRS Gene

  • Interacts with LAR-interacting protein LIP.1

Gene Wiki entry for PTPRS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRS Gene

Genomics for PTPRS Gene

Regulatory Elements for PTPRS Gene

Genomic Location for PTPRS Gene

5,158,495 bp from pter
5,340,803 bp from pter
182,309 bases
Minus strand

Genomic View for PTPRS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRS Gene

Proteins for PTPRS Gene

  • Protein details for PTPRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-type tyrosine-protein phosphatase S
    Protein Accession:
    Secondary Accessions:
    • O75255
    • O75870
    • Q15718
    • Q16341
    • Q2M3R7

    Protein attributes for PTPRS Gene

    1948 amino acids
    Molecular mass:
    217041 Da
    Quaternary structure:
    • Interacts with PPFIA1, PPFIA2 and PPFIA3.
    • Sequence=AAC50567.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRS Gene

    Alternative splice isoforms for PTPRS Gene

neXtProt entry for PTPRS Gene

Proteomics data for PTPRS Gene at MOPED

Post-translational modifications for PTPRS Gene

  • A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called ectodomain shedding is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).
  • Glycosylation at Asn263, Asn308, Asn733, and Asn940
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PTPRS (PTP sigma/PTPRS)

Domains for PTPRS Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
  • Contains 8 fibronectin type-III domains.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 tyrosine-protein phosphatase domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
genes like me logo Genes that share domains with PTPRS: view

Function for PTPRS Gene

Molecular function for PTPRS Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type sigma,putatively involved in the development of the nervous system
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Interacts with LAR-interacting protein LIP.1

Enzyme Numbers (IUBMB) for PTPRS Gene

Gene Ontology (GO) - Molecular Function for PTPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity --
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 8524829
GO:0005515 protein binding IPI 16273344
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPRS: view
genes like me logo Genes that share phenotypes with PTPRS: view

Animal Models for PTPRS Gene

MGI Knock Outs for PTPRS:

Animal Model Products

miRNA for PTPRS Gene

miRTarBase miRNAs that target PTPRS

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRS

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PTPRS Gene

Localization for PTPRS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRS Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PTPRS Gene COMPARTMENTS Subcellular localization image for PTPRS gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
cytosol 1
extracellular 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8524829
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PTPRS: view

Pathways for PTPRS Gene

genes like me logo Genes that share pathways with PTPRS: view

Pathways by source for PTPRS Gene

1 Qiagen pathway for PTPRS Gene
2 Reactome pathways for PTPRS Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0007155 cell adhesion IEA --
GO:0016311 dephosphorylation --
GO:0021510 spinal cord development IEA --
GO:0021549 cerebellum development IEA --
genes like me logo Genes that share ontologies with PTPRS: view

Drugs for PTPRS Gene

(2) Drugbank Compounds for PTPRS Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (4-Amino-1-hydroxybutylidene)bisphosphonic acid
66376-36-1 2088 Target inhibitor approved
Etidronic acid
  • (1-Hydroxyethylene)diphosphonic acid
7414-83-7 3305 Target inhibitor approved

(4) HMDB Compounds for PTPRS Gene

Compound Synonyms Cas Number PubMed IDs
Etidronic acid
  • Acetodiphosphonic acid
  • NFB Orthophosphate
Phosphoric acid
  • Acide phosphorique (FRENCH)
  • Dihydrogen oxide

(4) Novoseek inferred chemical compound relationships for PTPRS Gene

Compound -log(P) Hits PubMed IDs
tyrosine 74.1 60
alpha-latrotoxin 62.7 3
phosphotyrosine 44.9 2
heparan sulfate 21.9 1
genes like me logo Genes that share compounds with PTPRS: view

Transcripts for PTPRS Gene

Unigene Clusters for PTPRS Gene

Protein tyrosine phosphatase, receptor type, S:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - - - - -

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32

Relevant External Links for PTPRS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPRS Gene

mRNA expression in normal human tissues for PTPRS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PTPRS Gene

This gene is overexpressed in Cerebrospinal fluid (32.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRS Gene

SOURCE GeneReport for Unigene cluster for PTPRS Gene Hs.744928

mRNA Expression by UniProt/SwissProt for PTPRS Gene

Tissue specificity: Detected in all tissues tested except for placenta and liver
genes like me logo Genes that share expressions with PTPRS: view

Expression partners for PTPRS Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PTPRS Gene

Orthologs for PTPRS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPRS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PTPRS 35
  • 91.41 (n)
  • 96.97 (a)
  • 97 (a)
(Mus musculus)
Mammalia Ptprs 35
  • 86.42 (n)
  • 94.23 (a)
Ptprs 16
Ptprs 36
  • 94 (a)
(Pan troglodytes)
Mammalia PTPRS 35
  • 99.38 (n)
  • 99.79 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ptprs 35
  • 86.17 (n)
  • 93.72 (a)
(Canis familiaris)
Mammalia PTPRS 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia PTPRS 36
  • 92 (a)
(Gallus gallus)
Aves PTPRS 36
  • 90 (a)
(Anolis carolinensis)
Reptilia PTPRS 36
  • 76 (a)
(Danio rerio)
Actinopterygii ptprs 35
ptprsa 35
  • 71.6 (n)
  • 74 (a)
ptprsa 36
  • 73 (a)
ptprsb 36
  • 91 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lar 37
  • 39 (a)
Ptp52F 37
  • 41 (a)
Ptp69D 37
  • 35 (a)
Lar 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea F25H5.7 37
  • 34 (a)
F55F8.7 37
  • 35 (a)
K04D7.4 37
  • 35 (a)
T22C1.8 37
  • 33 (a)
Y48G9A.9 37
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTP1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1998 36
  • 45 (a)
Species with no ortholog for PTPRS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPRS Gene

Gene Tree for PTPRS (if available)
Gene Tree for PTPRS (if available)

Paralogs for PTPRS Gene

Paralogs for PTPRS Gene

genes like me logo Genes that share paralogs with PTPRS: view

Variants for PTPRS Gene

Sequence variations from dbSNP and Humsavar for PTPRS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12982462 -- 5,276,542(+) ttttt(G/T)tgttt intron-variant
rs12981952 -- 5,219,888(+) GGTCT(A/G)CCTCA intron-variant
rs12980156 -- 5,305,730(+) TCTCT(A/G)AAAAA intron-variant
rs12979710 -- 5,224,219(+) AGAAG(C/T)AAAGA intron-variant
rs12979222 -- 5,207,867(+) GAGCT(A/T)AGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRS Gene

Variant ID Type Subtype PubMed ID
nsv910875 CNV Loss 21882294
nsv833723 CNV Loss 17160897
nsv510750 CNV Loss 20534489
dgv3689n71 CNV Loss 21882294
dgv3690n71 CNV Loss 21882294
dgv3691n71 CNV Loss 21882294
esv1006709 CNV Loss 20482838
nsv833724 CNV Loss 17160897
nsv910890 CNV Loss 21882294
esv22199 CNV Loss 19812545
esv2718041 CNV Deletion 23290073
esv2718042 CNV Deletion 23290073
esv2667935 CNV Deletion 23128226

Relevant External Links for PTPRS Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRS Gene

Disorders for PTPRS Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PTPRS Gene in MalaCards »

(4) Diseases for PTPRS Gene

(3) University of Copenhagen DISEASES for PTPRS Gene

(1) Novoseek inferred disease relationships for PTPRS Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for PTPRS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PTPRS: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for PTPRS Gene

Publications for PTPRS Gene

  1. Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3. (PMID: 8954782) Wagner J. … Olsen A.S. (Genomics 1996) 2 3 23
  2. The LAR/PTP delta/PTP sigma subfamily of transmembrane protein- tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. (PMID: 8524829) Pulido R. … Streuli M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4
  3. Genetic variation in receptor protein tyrosine phosphatase sigma is associated with type 2 diabetes in Swedish Caucasians. (PMID: 17893260) LAYngberg E.C. … Ostenson C.G. (Eur. J. Endocrinol. 2007) 3 23 48
  4. Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. (PMID: 8992885) Endo N. … Schmidt A. (J. Bone Miner. Res. 1996) 3 4 23
  5. A new role for RPTPsigma in spinal cord injury: signaling chondroitin sulfate proteoglycan inhibition. (PMID: 20179269) Duan Y. … Giger R.J. (Sci Signal 2010) 3 23

Products for PTPRS Gene

Sources for PTPRS Gene

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