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Aliases for PTPRS Gene

Aliases for PTPRS Gene

  • Protein Tyrosine Phosphatase, Receptor Type S 2 3 5
  • Receptor-Type Tyrosine-Protein Phosphatase Sigma 3 4
  • R-PTP-Sigma 3 4
  • EC 4 61
  • R-PTP-S 3 4
  • Receptor-Type Tyrosine-Protein Phosphatase S 3
  • Protein Tyrosine Phosphatase PTPsigma 3

External Ids for PTPRS Gene

Previous GeneCards Identifiers for PTPRS Gene

  • GC19M005298
  • GC19M005146
  • GC19M004967

Summaries for PTPRS Gene

Entrez Gene Summary for PTPRS Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRS Gene

PTPRS (Protein Tyrosine Phosphatase, Receptor Type S) is a Protein Coding gene. Diseases associated with PTPRS include Pineal Gland Cancer and Ureterocele. Among its related pathways are Transmission across Chemical Synapses and Protein-protein interactions at synapses. GO annotations related to this gene include phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is ENSG00000283229.

UniProtKB/Swiss-Prot for PTPRS Gene

  • Interacts with LAR-interacting protein LIP.1.

Gene Wiki entry for PTPRS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRS Gene

Genomics for PTPRS Gene

Regulatory Elements for PTPRS Gene

Enhancers for PTPRS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F005313 0.4 ENCODE 19.9 +27.3 27339 0.2 HIC1 PKNOX1 NFIA KLF17 PRDM10 EBF1 WT1 PTPRS ZNRF4 LOC105372252 LOC105372253
GH19F005308 0.7 Ensembl ENCODE 17.8 +31.6 31561 1.8 SIN3A FEZF1 ZNF2 ZNF302 ZNF263 SP3 REST ZNF610 ZSCAN16 GLIS1 ENSG00000267571 VMAC ENSG00000267255 ENSG00000267030 PTPRS SH3GL1 SAFB2 RPL36 DPP9-AS1 ZNRF4
GH19F005253 0.2 ENCODE 16.6 +87.1 87128 1.0 ELF3 CTCF FOXA3 RCOR2 SMAD4 SPI1 PTPRS GC19P005263 GC19P005202
GH19F005339 1 FANTOM5 ENCODE 14.2 +1.2 1157 0.3 ATF1 ZNF76 GLIS2 CREM SP3 ZEB2 PPARG SMARCA4 GLIS1 IKZF1 PTPRS HSD11B1L LOC105372252
GH19F005398 0.5 ENCODE 11.8 -57.7 -57709 0.1 ZNF664 ZNF792 ADNP ZKSCAN8 ZNRF4 PTPRS GC19P005411
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PTPRS on UCSC Golden Path with GeneCards custom track

Promoters for PTPRS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001417566 503 1801 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 FOS

Genomic Location for PTPRS Gene

5,158,495 bp from pter
5,340,803 bp from pter
182,309 bases
Minus strand

Genomic View for PTPRS Gene

Genes around PTPRS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRS Gene

Proteins for PTPRS Gene

  • Protein details for PTPRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-type tyrosine-protein phosphatase S
    Protein Accession:
    Secondary Accessions:
    • O75255
    • O75870
    • Q15718
    • Q16341
    • Q2M3R7

    Protein attributes for PTPRS Gene

    1948 amino acids
    Molecular mass:
    217041 Da
    Quaternary structure:
    • Interacts with PPFIA1, PPFIA2 and PPFIA3.
    • Sequence=AAC50567.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRS Gene

    Alternative splice isoforms for PTPRS Gene

neXtProt entry for PTPRS Gene

Post-translational modifications for PTPRS Gene

  • A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called ectodomain shedding is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).
  • Glycosylation at Asn 263, Asn 308, Asn 733, and Asn 940
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PTPRS (PTP sigma/PTPRS)
  • Cloud-Clone Corp. Antibodies for PTPRS

Domains & Families for PTPRS Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
  • Contains 8 fibronectin type-III domains.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 tyrosine-protein phosphatase domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
genes like me logo Genes that share domains with PTPRS: view

Function for PTPRS Gene

Molecular function for PTPRS Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type sigma,putatively involved in the development of the nervous system
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Interacts with LAR-interacting protein LIP.1.

Enzyme Numbers (IUBMB) for PTPRS Gene

Gene Ontology (GO) - Molecular Function for PTPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 8524829
GO:0005515 protein binding IPI 16273344
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTPRS: view
genes like me logo Genes that share phenotypes with PTPRS: view

Animal Models for PTPRS Gene

MGI Knock Outs for PTPRS:

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRS Gene

Localization for PTPRS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRS Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PTPRS Gene COMPARTMENTS Subcellular localization image for PTPRS gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8524829
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PTPRS: view

Pathways & Interactions for PTPRS Gene

genes like me logo Genes that share pathways with PTPRS: view

SIGNOR curated interactions for PTPRS Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PTPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007155 cell adhesion IEA --
GO:0007268 chemical synaptic transmission TAS --
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with PTPRS: view

Drugs & Compounds for PTPRS Gene

(5) Drugs for PTPRS Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Etidronic acid Approved Pharma Target, inhibitor 82
Alendronate Approved Pharma Inhibition, Inhibitor, Target, inhibitor Bone resorption inhibitor, Osteoclast function modifiers (important in bone metastasis) 160
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(4) Additional Compounds for PTPRS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with PTPRS: view

Transcripts for PTPRS Gene

Unigene Clusters for PTPRS Gene

Protein tyrosine phosphatase, receptor type, S:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - - - - -

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32

Relevant External Links for PTPRS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPRS Gene

mRNA expression in normal human tissues for PTPRS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPRS Gene

This gene is overexpressed in Cerebrospinal fluid (32.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPRS Gene

Protein tissue co-expression partners for PTPRS Gene

NURSA nuclear receptor signaling pathways regulating expression of PTPRS Gene:


SOURCE GeneReport for Unigene cluster for PTPRS Gene:


mRNA Expression by UniProt/SwissProt for PTPRS Gene:

Tissue specificity: Detected in all tissues tested except for placenta and liver.
genes like me logo Genes that share expression patterns with PTPRS: view

Primer Products

No data available for mRNA differential expression in normal tissues for PTPRS Gene

Orthologs for PTPRS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPRS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTPRS 34 35
  • 99.38 (n)
(Ornithorhynchus anatinus)
Mammalia PTPRS 35
  • 92 (a)
(Bos Taurus)
Mammalia PTPRS 34 35
  • 91.41 (n)
(Mus musculus)
Mammalia Ptprs 34 16 35
  • 86.42 (n)
(Rattus norvegicus)
Mammalia Ptprs 34
  • 86.17 (n)
(Canis familiaris)
Mammalia PTPRS 35
  • 85 (a)
(Gallus gallus)
Aves PTPRS 35
  • 90 (a)
(Anolis carolinensis)
Reptilia PTPRS 35
  • 76 (a)
(Danio rerio)
Actinopterygii ptprsb 35
  • 91 (a)
ptprsa 34 35
  • 71.6 (n)
ptprs 34
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 36
  • 41 (a)
Lar 36 35
  • 39 (a)
Ptp69D 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea Y48G9A.9 36
  • 36 (a)
F55F8.7 36
  • 35 (a)
K04D7.4 36
  • 35 (a)
F25H5.7 36
  • 34 (a)
T22C1.8 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTP1 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1998 35
  • 45 (a)
Species where no ortholog for PTPRS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPRS Gene

Gene Tree for PTPRS (if available)
Gene Tree for PTPRS (if available)

Paralogs for PTPRS Gene

genes like me logo Genes that share paralogs with PTPRS: view

Variants for PTPRS Gene

Sequence variations from dbSNP and Humsavar for PTPRS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs775778266 A colorectal cancer sample 5,222,805(+) GCAGC(A/G)TGAGC intron-variant, reference, missense
rs1015674 -- 5,335,269(+) GAGGC(A/G)TGTTT intron-variant, nc-transcript-variant
rs1015675 -- 5,336,378(+) TGAGA(C/T)AACAG intron-variant, nc-transcript-variant
rs1017092 -- 5,274,975(+) CTCTG(A/G)GCTGG intron-variant
rs1017093 -- 5,281,848(+) CCAGC(A/G)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRS Gene

Variant ID Type Subtype PubMed ID
esv1006709 CNV loss 20482838
esv22199 CNV loss 19812545
esv2667935 CNV deletion 23128226
esv2718041 CNV deletion 23290073
esv2718042 CNV deletion 23290073
esv3574286 CNV gain 25503493
nsv1055783 CNV gain 25217958
nsv1072308 CNV deletion 25765185
nsv1077335 CNV duplication 25765185
nsv1113963 CNV deletion 24896259
nsv1118807 CNV deletion 24896259
nsv1118808 CNV deletion 24896259
nsv1123211 CNV deletion 24896259
nsv510750 CNV deletion 20534489
nsv833723 CNV loss 17160897
nsv833724 CNV loss 17160897
nsv953951 CNV deletion 24416366
nsv962995 CNV duplication 23825009

Variation tolerance for PTPRS Gene

Residual Variation Intolerance Score: 0.361% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRS Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRS Gene

Disorders for PTPRS Gene

MalaCards: The human disease database

(3) MalaCards diseases for PTPRS Gene - From: DISEASES

Disorder Aliases PubMed IDs
pineal gland cancer
  • malignant pineal region tumor
malignant ependymoma
  • ependymal neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search PTPRS in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPRS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PTPRS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRS Gene

Publications for PTPRS Gene

  1. Genetic variation in receptor protein tyrosine phosphatase sigma is associated with type 2 diabetes in Swedish Caucasians. (PMID: 17893260) LAYngberg E.C. … Ostenson C.G. (Eur. J. Endocrinol. 2007) 3 22 46 64
  2. Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3. (PMID: 8954782) Wagner J. … Olsen A.S. (Genomics 1996) 2 3 22 64
  3. Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. (PMID: 8992885) Endo N. … Schmidt A. (J. Bone Miner. Res. 1996) 3 4 22 64
  4. The LAR/PTP delta/PTP sigma subfamily of transmembrane protein- tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. (PMID: 8524829) Pulido R. … Streuli M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 64
  5. A new role for RPTPsigma in spinal cord injury: signaling chondroitin sulfate proteoglycan inhibition. (PMID: 20179269) Duan Y. … Giger R.J. (Sci Signal 2010) 3 22 64

Products for PTPRS Gene

Sources for PTPRS Gene

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