Aliases for PTPRR Gene
External Ids for PTPRR Gene
Previous HGNC Symbols for PTPRR Gene
Previous GeneCards Identifiers for PTPRR Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
GeneCards Summary for PTPRR Gene
PTPRR (Protein Tyrosine Phosphatase, Receptor Type R) is a Protein Coding gene. Among its related pathways are Signal transduction_Erk Interactions- Inhibition of Erk and PAK Pathway. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPN5.
UniProtKB/Swiss-Prot for PTPRR Gene
Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).