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Aliases for PTPRR Gene

Aliases for PTPRR Gene

  • Protein Tyrosine Phosphatase, Receptor Type R 2 3
  • Protein Tyrosine Phosphatase, Receptor Type, R 3 5
  • Protein-Tyrosine Phosphatase PCPTP1 3 4
  • EC 3.1.3.48 4 63
  • Ch-1PTPase 3 4
  • NC-PTPCOM1 3 4
  • R-PTP-R 3 4
  • PTPRQ 3 4
  • Protein-Tyrosine Phosphatase NC-PTPCOM1 3
  • Protein Tyrosine Phosphatase Cr1PTPase 3
  • Ch-1 PTPase 3
  • EC-PTP 3
  • PCPTP1 3
  • PTP-SL 3
  • PTPBR7 3
  • ECPTP 4

External Ids for PTPRR Gene

Previous HGNC Symbols for PTPRR Gene

  • PTPRQ

Previous GeneCards Identifiers for PTPRR Gene

  • GC12M070903
  • GC12M070748
  • GC12M069318
  • GC12M071031
  • GC12M068081

Summaries for PTPRR Gene

Entrez Gene Summary for PTPRR Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]

GeneCards Summary for PTPRR Gene

PTPRR (Protein Tyrosine Phosphatase, Receptor Type R) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and EGFR1 Signaling Pathway. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPN7.

UniProtKB/Swiss-Prot for PTPRR Gene

  • Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).

Gene Wiki entry for PTPRR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRR Gene

Genomics for PTPRR Gene

Regulatory Elements for PTPRR Gene

Enhancers for PTPRR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTPRR on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPRR Gene

Chromosome:
12
Start:
70,638,073 bp from pter
End:
70,920,843 bp from pter
Size:
282,771 bases
Orientation:
Minus strand

Genomic View for PTPRR Gene

Genes around PTPRR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRR Gene

Proteins for PTPRR Gene

  • Protein details for PTPRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15256-PTPRR_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase R
    Protein Accession:
    Q15256
    Secondary Accessions:
    • B2R5Z7
    • B7Z3J1
    • F5GXR7
    • O00342
    • Q92682
    • Q9UE65

    Protein attributes for PTPRR Gene

    Size:
    657 amino acids
    Molecular mass:
    73834 Da
    Quaternary structure:
    • Interacts with MAPKs.
    SequenceCaution:
    • Sequence=CAA57957.1; Type=Frameshift; Positions=651; Evidence={ECO:0000305}; Sequence=CAB01957.1; Type=Frameshift; Positions=651; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRR Gene

    Alternative splice isoforms for PTPRR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRR Gene

Proteomics data for PTPRR Gene at MOPED

Selected DME Specific Peptides for PTPRR Gene

Post-translational modifications for PTPRR Gene

  • Glycosylation at Asn 129
  • Modification sites at PhosphoSitePlus

Domains & Families for PTPRR Gene

Gene Families for PTPRR Gene

Graphical View of Domain Structure for InterPro Entry

Q15256

UniProtKB/Swiss-Prot:

PTPRR_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily.
genes like me logo Genes that share domains with PTPRR: view

Function for PTPRR Gene

Molecular function for PTPRR Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).

Enzyme Numbers (IUBMB) for PTPRR Gene

Gene Ontology (GO) - Molecular Function for PTPRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 7836467
genes like me logo Genes that share ontologies with PTPRR: view
genes like me logo Genes that share phenotypes with PTPRR: view

Animal Models for PTPRR Gene

MGI Knock Outs for PTPRR:

Animal Model Products

miRNA for PTPRR Gene

miRTarBase miRNAs that target PTPRR

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRR Gene

Localization for PTPRR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRR Gene

Isoform Alpha: Cell membrane; Single-pass type I membrane protein.
Isoform Delta: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.
Isoform Gamma: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRR Gene COMPARTMENTS Subcellular localization image for PTPRR gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 2
cytosol 1
endosome 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PTPRR Gene

Pathways & Interactions for PTPRR Gene

genes like me logo Genes that share pathways with PTPRR: view

Pathways by source for PTPRR Gene

2 BioSystems pathways for PTPRR Gene
1 KEGG pathway for PTPRR Gene
1 GeneGo (Thomson Reuters) pathway for PTPRR Gene
1 Qiagen pathway for PTPRR Gene

SIGNOR curated interactions for PTPRR Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PTPRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,TAS 7836467
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA,TAS --
GO:1903385 NOT regulation of homophilic cell adhesion IMP 21724833
genes like me logo Genes that share ontologies with PTPRR: view

Drugs & Compounds for PTPRR Gene

(1) Drugs for PTPRR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for PTPRR Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTPRR: view

Transcripts for PTPRR Gene

Unigene Clusters for PTPRR Gene

Protein tyrosine phosphatase, receptor type, R:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: -
SP5: -

Relevant External Links for PTPRR Gene

GeneLoc Exon Structure for
PTPRR
ECgene alternative splicing isoforms for
PTPRR

Expression for PTPRR Gene

mRNA expression in normal human tissues for PTPRR Gene

mRNA differential expression in normal tissues according to GTEx for PTPRR Gene

This gene is overexpressed in Brain - Cerebellum (x8.2), Brain - Cerebellar Hemisphere (x7.5), Brain - Anterior cingulate cortex (BA24) (x5.1), Brain - Cortex (x4.1), and Brain - Frontal Cortex (BA9) (x4.0).

SOURCE GeneReport for Unigene cluster for PTPRR Gene Hs.506076

mRNA Expression by UniProt/SwissProt for PTPRR Gene

Q15256-PTPRR_HUMAN
Tissue specificity: Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus.
genes like me logo Genes that share expression patterns with PTPRR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PTPRR Gene

Orthologs for PTPRR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPRR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRR 35
  • 91.55 (n)
  • 93.44 (a)
PTPRR 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRR 35
  • 92.22 (n)
  • 95.87 (a)
PTPRR 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprr 35
  • 86.64 (n)
  • 89.33 (a)
Ptprr 16
Ptprr 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPRR 35
  • 99.59 (n)
  • 99.24 (a)
PTPRR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprr 35
  • 86.69 (n)
  • 89.33 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPRR 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRR 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRR 35
  • 78.52 (n)
  • 83.82 (a)
PTPRR 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRR 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprr 35
  • 72.8 (n)
  • 74.81 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398636 35
zebrafish
(Danio rerio)
Actinopterygii ptprr 35
  • 61.16 (n)
  • 63.3 (a)
PTPRR 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42327 36
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTP1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for PTPRR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTPRR Gene

ENSEMBL:
Gene Tree for PTPRR (if available)
TreeFam:
Gene Tree for PTPRR (if available)

Paralogs for PTPRR Gene

Paralogs for PTPRR Gene

Pseudogenes.org Pseudogenes for PTPRR Gene

genes like me logo Genes that share paralogs with PTPRR: view

Variants for PTPRR Gene

Sequence variations from dbSNP and Humsavar for PTPRR Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_014283 -
VAR_057140 -
rs35387004 - 70,701,175(+) CACGA(A/C/T)GTCCC intron-variant, reference, missense
rs35390084 - 70,684,748(+) GGTTA(C/T)ATTTT nc-transcript-variant, reference, missense
rs1996090 -- 70,834,028(-) AAAAC(A/G/T)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRR Gene

Variant ID Type Subtype PubMed ID
esv32743 CNV Gain 17666407
nsv509472 CNV Insertion 20534489
nsv518982 CNV Loss 19592680
esv1004350 CNV Insertion 20482838
esv2664329 CNV Deletion 23128226
esv2746025 CNV Deletion 23290073
esv2082743 CNV Deletion 18987734
esv2746026 CNV Deletion 23290073
esv2746027 CNV Deletion 23290073
esv2746028 CNV Deletion 23290073
esv2746032 CNV Deletion 23290073
nsv53686 CNV Loss 16902084
esv2677966 CNV Deletion 23128226
nsv436048 CNV Insertion 17901297

Variation tolerance for PTPRR Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PTPRR Gene

Disorders for PTPRR Gene

Relevant External Links for PTPRR

Genetic Association Database (GAD)
PTPRR
Human Genome Epidemiology (HuGE) Navigator
PTPRR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRR

No disorders were found for PTPRR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPRR Gene

Publications for PTPRR Gene

  1. Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase. (PMID: 7557444) Shiozuka K. … Kawashima H. (Gene 1995) 2 3 4 67
  2. The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis. (PMID: 20015382) Menigatti M. … Marra G. (Mol. Cancer 2009) 3 23
  3. ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1. (PMID: 16148006) TA!rrega C. … Pulido R. (J. Biol. Chem. 2005) 3 23
  4. Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway. (PMID: 12042304) Buschbeck M. … Ullrich A. (J. Biol. Chem. 2002) 3 23
  5. Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes. (PMID: 11147789) Bektas A. … Doria A. (Diabetes 2001) 3 23

Products for PTPRR Gene

Sources for PTPRR Gene

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