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Aliases for PTPRR Gene

Aliases for PTPRR Gene

  • Protein Tyrosine Phosphatase, Receptor Type, R 2 3
  • Protein-Tyrosine Phosphatase PCPTP1 3 4
  • EC 3.1.3.48 4 63
  • Ch-1PTPase 3 4
  • NC-PTPCOM1 3 4
  • R-PTP-R 3 4
  • PTPRQ 3 4
  • Receptor-Type Tyrosine-Protein Phosphatase R 3
  • Protein-Tyrosine Phosphatase NC-PTPCOM1 3
  • Protein Tyrosine Phosphatase Cr1PTPase 3
  • Ch-1 PTPase 3
  • EC-PTP 3
  • PCPTP1 3
  • PTP-SL 3
  • PTPBR7 3
  • ECPTP 4

External Ids for PTPRR Gene

Previous HGNC Symbols for PTPRR Gene

  • PTPRQ

Previous GeneCards Identifiers for PTPRR Gene

  • GC12M070903
  • GC12M070748
  • GC12M069318
  • GC12M071031
  • GC12M068081

Summaries for PTPRR Gene

Entrez Gene Summary for PTPRR Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]

GeneCards Summary for PTPRR Gene

PTPRR (Protein Tyrosine Phosphatase, Receptor Type, R) is a Protein Coding gene. Diseases associated with PTPRR include colorectal cancer. Among its related pathways are MAPK signaling pathway and PAK Pathway. GO annotations related to this gene include protein kinase binding and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRO.

UniProtKB/Swiss-Prot for PTPRR Gene

  • Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).

Gene Wiki entry for PTPRR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRR Gene

Genomics for PTPRR Gene

Regulatory Elements for PTPRR Gene

Genomic Location for PTPRR Gene

Start:
70,638,073 bp from pter
End:
70,920,843 bp from pter
Size:
282,771 bases
Orientation:
Minus strand

Genomic View for PTPRR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRR Gene

Proteins for PTPRR Gene

  • Protein details for PTPRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15256-PTPRR_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase R
    Protein Accession:
    Q15256
    Secondary Accessions:
    • B2R5Z7
    • B7Z3J1
    • F5GXR7
    • O00342
    • Q92682
    • Q9UE65

    Protein attributes for PTPRR Gene

    Size:
    657 amino acids
    Molecular mass:
    73834 Da
    Quaternary structure:
    • Interacts with MAPKs.
    SequenceCaution:
    • Sequence=CAA57957.1; Type=Frameshift; Positions=651; Evidence={ECO:0000305}; Sequence=CAB01957.1; Type=Frameshift; Positions=651; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRR Gene

    Alternative splice isoforms for PTPRR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRR Gene

Proteomics data for PTPRR Gene at MOPED

Selected DME Specific Peptides for PTPRR Gene

Post-translational modifications for PTPRR Gene

  • Glycosylation at Asn129
  • Modification sites at PhosphoSitePlus

Domains for PTPRR Gene

Gene Families for PTPRR Gene

HGNC:
  • PTPR :Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q15256

UniProtKB/Swiss-Prot:

PTPRR_HUMAN :
  • Q15256
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily.
genes like me logo Genes that share domains with PTPRR: view

Function for PTPRR Gene

Molecular function for PTPRR Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).

Enzyme Numbers (IUBMB) for PTPRR Gene

Gene Ontology (GO) - Molecular Function for PTPRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity TAS 7836467
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 7836467
GO:0005515 protein binding IPI 10601328
GO:0016791 phosphatase activity --
GO:0019901 protein kinase binding ISS --
genes like me logo Genes that share ontologies with PTPRR: view
genes like me logo Genes that share phenotypes with PTPRR: view

Animal Models for PTPRR Gene

MGI Knock Outs for PTPRR:

Animal Model Products

CRISPR Products

miRNA for PTPRR Gene

miRTarBase miRNAs that target PTPRR

No data available for Transcription Factor Targeting and HOMER Transcription for PTPRR Gene

Localization for PTPRR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRR Gene

Isoform Alpha: Cell membrane; Single-pass type I membrane protein.
Isoform Delta: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.
Isoform Gamma: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRR Gene COMPARTMENTS Subcellular localization image for PTPRR gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3
endoplasmic reticulum 2
endosome 1
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005737 cytoplasm --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with PTPRR: view

Pathways for PTPRR Gene

genes like me logo Genes that share pathways with PTPRR: view

Pathways by source for PTPRR Gene

1 Qiagen pathway for PTPRR Gene
2 BioSystems pathways for PTPRR Gene
1 KEGG pathway for PTPRR Gene
1 GeneGo (Thomson Reuters) pathway for PTPRR Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEP 10601328
GO:0006470 protein dephosphorylation TAS 7836467
GO:0010633 negative regulation of epithelial cell migration IMP 21724833
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 7836467
genes like me logo Genes that share ontologies with PTPRR: view

Compounds for PTPRR Gene

(2) HMDB Compounds for PTPRR Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(1) Novoseek inferred chemical compound relationships for PTPRR Gene

Compound -log(P) Hits PubMed IDs
tyrosine 61.5 13
genes like me logo Genes that share compounds with PTPRR: view

Transcripts for PTPRR Gene

Unigene Clusters for PTPRR Gene

Protein tyrosine phosphatase, receptor type, R:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: -
SP5: -

Relevant External Links for PTPRR Gene

GeneLoc Exon Structure for
PTPRR
ECgene alternative splicing isoforms for
PTPRR

Expression for PTPRR Gene

mRNA expression in normal human tissues for PTPRR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRR Gene

This gene is overexpressed in Brain - Cerebellum (8.2), Brain - Cerebellar Hemisphere (7.5), Brain - Anterior cingulate cortex (BA24) (5.1), Brain - Cortex (4.1), and Brain - Frontal Cortex (BA9) (4.0).

SOURCE GeneReport for Unigene cluster for PTPRR Gene Hs.506076

mRNA Expression by UniProt/SwissProt for PTPRR Gene

Q15256-PTPRR_HUMAN
Tissue specificity: Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus.
genes like me logo Genes that share expressions with PTPRR: view

In Situ Assay Products

No data available for Protein expression for PTPRR Gene

Orthologs for PTPRR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPRR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRR 35
  • 99.59 (n)
  • 99.24 (a)
PTPRR 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRR 35
  • 91.55 (n)
  • 93.44 (a)
PTPRR 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRR 35
  • 92.22 (n)
  • 95.87 (a)
PTPRR 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprr 35
  • 86.64 (n)
  • 89.33 (a)
Ptprr 16
Ptprr 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPRR 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRR 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprr 35
  • 86.69 (n)
  • 89.33 (a)
chicken
(Gallus gallus)
Aves PTPRR 35
  • 78.52 (n)
  • 83.82 (a)
PTPRR 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRR 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398636 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprr 35
  • 72.8 (n)
  • 74.81 (a)
zebrafish
(Danio rerio)
Actinopterygii ptprr 35
  • 61.16 (n)
  • 63.3 (a)
PTPRR 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42327 36
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTP1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for PTPRR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTPRR Gene

ENSEMBL:
Gene Tree for PTPRR (if available)
TreeFam:
Gene Tree for PTPRR (if available)

Paralogs for PTPRR Gene

Paralogs for PTPRR Gene

Pseudogenes.org Pseudogenes for PTPRR Gene

genes like me logo Genes that share paralogs with PTPRR: view

Variants for PTPRR Gene

Sequence variations from dbSNP and Humsavar for PTPRR Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs767760 -- 70,646,356(-) TGTCT(A/G)TGTTC intron-variant
rs883980 -- 70,816,212(+) GGTGC(A/G)CAAAT intron-variant
rs907751 -- 70,828,275(-) ATCAA(A/G)GGGCA intron-variant
rs907752 -- 70,828,210(-) TTTAA(C/T)TACTA intron-variant
rs907753 -- 70,825,858(-) CCTTA(C/T)GTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRR Gene

Variant ID Type Subtype PubMed ID
esv32743 CNV Gain 17666407
nsv509472 CNV Insertion 20534489
nsv518982 CNV Loss 19592680
esv1004350 CNV Insertion 20482838
esv2664329 CNV Deletion 23128226
esv2746025 CNV Deletion 23290073
esv2082743 CNV Deletion 18987734
esv2746026 CNV Deletion 23290073
esv2746027 CNV Deletion 23290073
esv2746028 CNV Deletion 23290073
esv2746032 CNV Deletion 23290073
nsv53686 CNV Loss 16902084
esv2677966 CNV Deletion 23128226
nsv436048 CNV Insertion 17901297

Relevant External Links for PTPRR Gene

HapMap Linkage Disequilibrium report
PTPRR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRR Gene

Disorders for PTPRR Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PTPRR Gene including...

Search for PTPRR Gene in MalaCards »

Relevant External Links for PTPRR

Genetic Association Database (GAD)
PTPRR
Human Genome Epidemiology (HuGE) Navigator
PTPRR
genes like me logo Genes that share disorders with PTPRR: view

No data available for UniProtKB/Swiss-Prot for PTPRR Gene

Publications for PTPRR Gene

  1. Protein tyrosine phosphatase (PC12, Br7,Sl) family: expression characterization in the adult human and mouse. (PMID: 10705342) Augustine K.A. … Medlock E.S. (Anat. Rec. 2000) 3 4 23
  2. Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes. (PMID: 11147789) Bektas A. … Doria A. (Diabetes 2001) 3 4 23
  3. Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase. (PMID: 7557444) Shiozuka K. … Kawashima H. (Gene 1995) 2 3 4
  4. ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1. (PMID: 16148006) TA!rrega C. … Pulido R. (J. Biol. Chem. 2005) 3 23
  5. PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif. (PMID: 9857190) Pulido R. … Ullrich A. (EMBO J. 1998) 3 23

Products for PTPRR Gene

  • Addgene plasmids for PTPRR

Sources for PTPRR Gene

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