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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPRR Gene

protein-coding   GIFtS: 66
GCID: GC12M071031

Protein Tyrosine Phosphatase, Receptor Type, R


(Previous symbol: PTPRQ)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Protein Tyrosine Phosphatase, Receptor Type, R1 2     PTPBR72
PTPRQ1 2 3     Ch-1 PTPase2
Protein-Tyrosine Phosphatase PCPTP12 3     ch-1PTPase2
NC-PTPCOM12 3     Protein Tyrosine Phosphatase Cr1PTPase2
R-PTP-R2 3     Protein-Tyrosine Phosphatase NC-PTPCOM12
EC 3.1.3.483 8     Receptor-Type Tyrosine-Protein Phosphatase R2
EC-PTP2     Ch-1PTPase3
PCPTP12     ECPTP3
PTP-SL2     

External Ids:    HGNC: 96801   Entrez Gene: 58012   Ensembl: ENSG000001532337   OMIM: 6028535   UniProtKB: Q152563   
ORGUL members:         
NONCODE14:n342899      

Export aliases for PTPRR gene to outside databases

Previous GC identifers: GC12M070903 GC12M070748 GC12M069318 GC12M068081


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPRR Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane
region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this
gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have
been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase,
receptor type, Q (GeneID 374462), which is also located on chromosome 12. (provided by RefSeq, May 2011)

GeneCards Summary for PTPRR Gene: 
PTPRR (protein tyrosine phosphatase, receptor type, R) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with PTPRR include episodic ataxia, and colorectal cancer, and among its related super-pathways are MAPK signaling pathway and Signal transduction Erk Interactions- Inhibition of Erk. GO annotations related to this gene include protein kinase binding and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPN7.

UniProtKB/Swiss-Prot: PTPRR_HUMAN, Q15256
Function: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in
an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the
protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity)

Gene Wiki entry for PTPRR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPRR gene promoter:
         MEF-2A   Nkx2-2   NRSF form 1   aMEF-2   NRSF form 2   Gfi-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPRR promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPRR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPRR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

PTPRR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRR gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M071031:  view genomic region     (about GC identifiers)

Start:
71,031,853 bp from pter      End:
71,314,623 bp from pter
Size:
282,771 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for PTPRR

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTPRR_HUMAN, Q15256 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein phosphatase R precursor  
Size: 657 amino acids; 73834 Da
Subunit: Interacts with MAPKs (By similarity)
Subcellular location: Isoform Alpha: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform Delta: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within
the cytoplasm
Subcellular location: Isoform Gamma: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within
the cytoplasm
Sequence caution: Sequence=CAA57957.1; Type=Frameshift; Positions=651; Sequence=CAB01957.1; Type=Frameshift;
Positions=651;
1 PDB 3D structure from and Proteopedia for PTPRR:
2A8B (3D)    
Secondary accessions: B2R5Z7 B7Z3J1 F5GXR7 O00342 Q92682 Q9UE65
Alternative splicing: 4 isoforms:  Q15256-1   Q15256-3   Q15256-4   Q15256-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPRR: NX_Q15256

Explore proteomics data for PTPRR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15256

  • 4/7 DME Specific Peptides for PTPRR (Q15256) (see all 7)
     GRTGCFI  LMLDVEE  LQERRGS  VVHCSAG 

    PTPRR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTPRR Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001193944.1  NP_001193945.1  NP_002840.2  NP_570897.2  

    ENSEMBL proteins: 
     ENSP00000391750   ENSP00000448049   ENSP00000283228   ENSP00000339605   ENSP00000446943  
     ENSP00000449616   ENSP00000368054  

    Human Recombinant Protein Products for PTPRR: 
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    OriGene MassSpec for PTPRR 
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    Novus Biologicals PTPRR Protein
    Novus Biologicals PTPRR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTPRR 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IDA12493773

    PTPRR for ontologies           About GeneDecksing



    PTPRR Antibody Products: 
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    Abcam antibodies for PTPRR
    Cloud-Clone Corp. Antibodies for PTPRR 
    ThermoFisher Antibodies for PTPRR
    LSBio Antibodies in human, mouse, rat for PTPRR 

    Assay Products for PTPRR: 
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    Cloud-Clone Corp. ELISAs for PTPRR 
    Cloud-Clone Corp. CLIAs for PTPRR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PTPR: Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like

    IUPHAR Guide to PHARMACOLOGY protein family classification: Type R 
    Receptor tyrosine phosphatases (RTP)

    5 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR008356 Tyr_Pase_KIM-con
     IPR016334 Tyr_Pase_rcpt_R/non-rcpt_5
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry Q15256

    ProtoNet protein and cluster: Q15256

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTPRR_HUMAN, Q15256
    Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    PTPRR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTPRR_HUMAN, Q15256
    Function: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in
    an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the
    protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity TAS7836467
    GO:0005001transmembrane receptor protein tyrosine phosphatase activity TAS7836467
    GO:0005515protein binding IPI10601328
    GO:0016791phosphatase activity ----
    GO:0019901protein kinase binding ISS--
         
    PTPRR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PTPRR:
     Increased cell death in breast  Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ptprr):
     behavior/neurological  nervous system 

    PTPRR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptprrtm1Wjh for PTPRR

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTPRR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTPRR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPRR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPRR 

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPRR (see all 17):
    hsa-miR-644 hsa-miR-15a hsa-miR-503 hsa-miR-218 hsa-miR-424 hsa-miR-3662 hsa-miR-195 hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidPTPRR 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PTPRR (NM_130846)
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                         Customized lentivirus expression plasmids for stable overexpression of PTPRR 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTPRR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Signal transduction Erk Interactions: Inhibition of Erk
    Signal transduction Erk Interactions: Inhibition of Erk0.92
    3PAK Pathway
    Epithelial Adherens Junctions0.36
    4EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PTPRR
        Signal transduction Erk Interactions- Inhibition of Erk

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPRR
        Epithelial Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for PTPRR
        Signal transduction Erk Interactions- Inhibition of Erk

    2 BioSystems Pathways for PTPRR
        MAPK signaling pathway
    EGFR1 Signaling Pathway


    1         Kegg Pathway  (Kegg details for PTPRR):
        MAPK signaling pathway


    PTPRR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPRR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/14 Interacting proteins for PTPRR (Q152562, 3 ENSP000002832284) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284822, 3, ENSP000002158324MINT-8213686 MINT-8213408 I2D: score=5 STRING: ENSP00000215832
    MAPK14Q165392, 3, ENSP000002297944MINT-8213389 MINT-8213424 MINT-8213705 I2D: score=2 STRING: ENSP00000229794
    MAPK3P273613, ENSP000002630254I2D: score=2 STRING: ENSP00000263025
    CDH2P190223, ENSP000002691414I2D: score=1 STRING: ENSP00000269141
    MAPK7Q131643, ENSP000003110054I2D: score=1 STRING: ENSP00000311005
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEP10601328
    GO:0006470protein dephosphorylation TAS7836467
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation ----

    PTPRR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTPRR for compounds           About GeneDecksing

    EMD Millipore small molecules for PTPRR:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPRR

    2 HMDB Compounds for PTPRR    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 Novoseek inferred chemical compound relationship for PTPRR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 61.5 14 9857190 (2), 12802008 (2), 20015382 (2), 16061641 (2) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about PTPRR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTPRR gene (4 alternative transcripts): 
    NM_001207015.1  NM_001207016.1  NM_002849.3  NM_130846.2  

    Unigene Cluster for PTPRR:

    Protein tyrosine phosphatase, receptor type, R
    Hs.506076  [show with all ESTs]
    Unigene Representative Sequence: NM_002849
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440835(uc001swh.2 uc009zrs.3) ENST00000537619(uc001swf.2 uc001swg.2)
    ENST00000551219 ENST00000547752 ENST00000283228(uc010stq.2 uc001swi.2)
    ENST00000342084 ENST00000549308 ENST00000549107 ENST00000548220(uc010str.1)
    ENST00000550661 ENST00000378778
    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPRR (see all 17):
    hsa-miR-644 hsa-miR-15a hsa-miR-503 hsa-miR-218 hsa-miR-424 hsa-miR-3662 hsa-miR-195 hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidPTPRR 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRR
    Sirion Biotech Customized lentivirus for stable overexpression of PTPRR 
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    Additional mRNA sequence: 

    AK091647.1 AK295951.1 AK304457.1 AK304672.1 AK312376.1 BC072386.1 BC092469.1 BC110900.1 
    BC119777.1 BC122866.1 BX571751.1 CR749836.1 D64053.1 NR_073474.1 U42361.1 U77916.1 
    U77917.1 X82635.1 Z79693.1 

    6 DOTS entries:

    DT.454039  DT.95366889  DT.97788807  DT.121209765  DT.100022077  DT.91739317 

    24/60 AceView cDNA sequences (see all 60):

    BQ439823 R50771 BU631692 NM_130846 CR625935 AI833024 AI400629 BQ641282 
    BC072386 CR749836 CA435261 BM463272 U77916 U77917 U42361 CA425069 
    BX952611 AK091647 BX417576 AL711271 AL556231 BX384306 BI668220 Z79693 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PTPRR    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17
    SP1:                          -                                         -     -     -           -                       -         
    SP2:                                            -                             -     -           -                                 
    SP3:                                                                    -     -     -           -                       -         
    SP4:                                                                                                                    -         
    SP5:                                                                                            -                                 


    ECgene alternative splicing isoforms for PTPRR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPRR expression in normal human tissues (normalized intensities)      PTPRR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCAACACCG
    PTPRR Expression
    About this image


    PTPRR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebellum
             cerebellum   
     
     Uterus (Reproductive System)    fully expand to see all 6 entries
             uterus, post-menopause ; glandular cells   
             CERVIX   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   

    See PTPRR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPRR

    SOURCE GeneReport for Unigene cluster: Hs.506076

    UniProtKB/Swiss-Prot: PTPRR_HUMAN, Q15256
    Tissue specificity: Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate.
    Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus.
    Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus

        SABiosciences Expression via Pathway-Focused PCR Array including PTPRR: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PTPRR gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptprr1 , 5 protein tyrosine phosphatase, receptor type, R1, 5 86.64(n)1
    89.33(a)1
      10 (64.01 cM)5
    192791  NM_011217.21  NP_035347.11 
     1160182135 
    chicken
    (Gallus gallus)
    Aves PTPRR1 protein tyrosine phosphatase, receptor type, R 78.67(n)
    84.12(a)
      771985  XM_001235187.2  XP_001235188.2 
    lizard
    (Anolis carolinensis)
    Reptilia PTPRR6
    protein tyrosine phosphatase, receptor type, R
    80(a)
    1 ↔ 1
    5(37982877-38115241)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986362 hypothetical protein LOC398636 74.89(n)    BC054196.1 
    zebrafish
    (Danio rerio)
    Actinopterygii PTPRR6
    protein tyrosine phosphatase, receptor type, R
    61(a)
    1 ↔ 1
    4(59603883-59639641)
    worm
    (Caenorhabditis elegans)
    Secernentea K07F5.86
    C55B7.36
    (see all 24)
    Protein C55B7.3
    (see all 24)
    27(a)
    24(a)
    (see all 24)
    many ↔ many
    many ↔ many
    (see all 24)
    IV(9848483-9849724)
    I(6499841-6501413)


    ENSEMBL Gene Tree for PTPRR (if available)
    TreeFam Gene Tree for PTPRR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPRR gene
    PTPN72  PTPN52  
    18/41 SIMAP similar genes for PTPRR using alignment to 7 protein entries:     PTPRR_HUMAN (see all proteins) (see all similar genes):
    DKFZp686K0257    DKFZp781C1038    PTPN5    PTPN7    PTPRH    PTPRD
    PTPsigma    PTPRA    PTPN6    PTPRS    LAR    DKFZp686B1310
    DKFZp686C2268    PTPN13    PTPN20A    PTPN20B    PTPRC    DKFZp566K0524

    PTPRR for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PTPRR
    PGOHUM00000261345


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5434 SNPs in PTPRR are shown (see all 5434)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs664992651,2
    C--68163767(+) TTTTT-/TT/TTT
            
    GAGAC
    5 -- int11NA 2
    rs666054231,2
    C--70937568(-) ACTTG-/TTTTTTT 5 -- int12Minor allele frequency- TT:0.25NA 4
    rs680945241,2
    C--70940330(-) GTGTG-/TGTGTT
            
    TGTAT
    5 -- int11Minor allele frequency- TGTGTT:0.00NA 2
    rs125787911,2
    C,F,A,H--71033268(+) TTCCCA/GGCACA 5 -- int110Minor allele frequency- G:0.08NA CSA WA EA 686
    rs171084801,2
    C,F,H--71033283(+) AGGCAC/TGTGAT 5 -- int19Minor allele frequency- T:0.01NA NS EA CSA WA 680
    rs1491160091,2
    --71033424(+) TTCCTC/TGAAAC 5 -- int1 nc-transcript-variant0--------
    rs21971271,2
    C,F,H--71033425(-) GGTTTC/TGAGGA 5 -- int1 nc-transcript-variant4Minor allele frequency- T:0.00NS EA 420
    rs762560861,2
    C,F--71033487(+) CTGCTG/CTGAAG 5 -- int12Minor allele frequency- C:0.10CSA WA 122
    rs125826421,2
    C,F,A,H--71033651(+) TAAAAT/CGAAGT 5 -- int116Minor allele frequency- C:0.11NS EA NA CSA WA 1340
    rs1872994001,2
    --71033681(+) TTGAAC/TATGTT 5 -- int10--------

    HapMap Linkage Disequilibrium report for PTPRR (71031853 - 71281853 bp, first 250kb of PTPRR)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for PTPRR (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746032CNV Deletion23290073
    esv2746028CNV Deletion23290073
    esv2664329CNV Deletion23128226
    esv2746025CNV Deletion23290073
    esv2082743CNV Deletion18987734
    esv2677966CNV Deletion23128226
    esv2746026CNV Deletion23290073
    esv2746027CNV Deletion23290073
    esv1004350CNV Insertion20482838
    nsv509472CNV Insertion20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602853    OMIM disorders: --

    7 diseases for PTPRR:    About MalaCards
    episodic ataxia    colorectal cancer    major depressive disorder    ataxia
    leukemia    prostatitis    neuronitis


    PTPRR for disorders           About GeneDecksing

    Genetic Association Database (GAD): PTPRR
    Human Genome Epidemiology (HuGE) Navigator: PTPRR (3 documents)

    Export disorders for PTPRR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPRR gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with PTPRR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase. (PubMed id 7557444)1, 2, 3 Shiozuka K.... Kawashima H. (1995)
    2. Protein tyrosine phosphatase (PC12, Br7,Sl) family: expression characterization in the adult human and mouse. (PubMed id 10705342)1, 2, 9 Augustine K.A.... Medlock E.S. (2000)
    3. Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes. (PubMed id 11147789)1, 2, 9 Bektas A.... Doria A. (2001)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    6. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. (PubMed id 16441242)1, 2 Eswaran J.... Barr A.J. (2006)
    7. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Assignment1 of the PTP-SL/PTPBR7 gene (Ptprr/PTPRR) to mouse chromosome region 8A2 by in situ hybridization. (PubMed id 10393441)1, 3 van den Maagdenberg A.M....Hendriks W.J. (1999)
    10. PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif. (PubMed id 9857190)1, 9 Pulido R....Ullrich A. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5801 HGNC: 9680 AceView: PTPRR Ensembl:ENSG00000153233 euGenes: HUgn5801
    ECgene: PTPRR Kegg: 5801 H-InvDB: PTPRR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPRR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPRR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTPRR gene:
    Search GeneIP for patents involving PTPRR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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