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Aliases for PTPRO Gene

Aliases for PTPRO Gene

  • Protein Tyrosine Phosphatase, Receptor Type O 2 3
  • Osteoclastic Transmembrane Protein-Tyrosine Phosphatase 2 3
  • Protein Tyrosine Phosphatase, Receptor Type, O 3 5
  • Glomerular Epithelial Protein 1 3 4
  • EC 3.1.3.48 4 63
  • PTPase U2 3 4
  • R-PTP-O 3 4
  • GLEPP1 3 4
  • PTP-U2 3 4
  • PTPU2 3 4
  • Protein Tyrosine Phosphatase PTP-U2 3
  • Protein Tyrosine Phosphatase U2 4
  • Phosphotyrosine Phosphatase U2 3
  • PTP Phi 3
  • PTP-OC 3
  • PTPROT 3
  • NPHS6 3

External Ids for PTPRO Gene

Previous GeneCards Identifiers for PTPRO Gene

  • GC12P015215
  • GC12P015620
  • GC12P015375
  • GC12P015476

Summaries for PTPRO Gene

Entrez Gene Summary for PTPRO Gene

  • This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]

GeneCards Summary for PTPRO Gene

PTPRO (Protein Tyrosine Phosphatase, Receptor Type O) is a Protein Coding gene. Diseases associated with PTPRO include Nephrotic Syndrome, Type 6 and Familial Idiopathic Steroid-Resistant Nephrotic Syndrome With Minimal Changes. Among its related pathways are Kit Receptor Signaling Pathway and PAK Pathway. GO annotations related to this gene include protein homodimerization activity and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRQ.

UniProtKB/Swiss-Prot for PTPRO Gene

  • Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).

Gene Wiki entry for PTPRO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRO Gene

Genomics for PTPRO Gene

Regulatory Elements for PTPRO Gene

Enhancers for PTPRO Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTPRO on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPRO Gene

Chromosome:
12
Start:
15,322,257 bp from pter
End:
15,598,331 bp from pter
Size:
276,075 bases
Orientation:
Plus strand

Genomic View for PTPRO Gene

Genes around PTPRO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRO Gene

Proteins for PTPRO Gene

  • Protein details for PTPRO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16827-PTPRO_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase O
    Protein Accession:
    Q16827
    Secondary Accessions:
    • A0AV39
    • Q13101
    • Q8IYG3
    • Q9UBF0
    • Q9UBT5

    Protein attributes for PTPRO Gene

    Size:
    1216 amino acids
    Molecular mass:
    138344 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPRO Gene

    Alternative splice isoforms for PTPRO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRO Gene

Proteomics data for PTPRO Gene at MOPED

Selected DME Specific Peptides for PTPRO Gene

Post-translational modifications for PTPRO Gene

  • Glycosylation at Asn 75, Asn 154, Asn 189, Asn 201, Asn 227, Asn 278, Asn 287, Asn 323, Asn 324, Asn 370, Asn 461, Asn 490, Asn 700, Asn 712, and Asn 733
  • Modification sites at PhosphoSitePlus

Domains & Families for PTPRO Gene

Graphical View of Domain Structure for InterPro Entry

Q16827

UniProtKB/Swiss-Prot:

PTPRO_HUMAN :
  • Contains 8 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
Domain:
  • Contains 8 fibronectin type-III domains.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
genes like me logo Genes that share domains with PTPRO: view

Function for PTPRO Gene

Molecular function for PTPRO Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor type,U2 polypeptide,identical to PTPU2-LSB from glomerular epithelial podocyte membrane protein
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).
UniProtKB/Swiss-Prot Induction:
By various differentiation-inducing agents.

Enzyme Numbers (IUBMB) for PTPRO Gene

Gene Ontology (GO) - Molecular Function for PTPRO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity NAS 7665166
genes like me logo Genes that share ontologies with PTPRO: view
genes like me logo Genes that share phenotypes with PTPRO: view

Human Phenotype Ontology for PTPRO Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPRO Gene

MGI Knock Outs for PTPRO:

Animal Model Products

miRNA for PTPRO Gene

miRTarBase miRNAs that target PTPRO

No data available for Transcription Factor Targets and HOMER Transcription for PTPRO Gene

Localization for PTPRO Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRO Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRO Gene COMPARTMENTS Subcellular localization image for PTPRO gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane NAS 7665166
GO:0016328 lateral plasma membrane ISS --
GO:0030027 lamellipodium ISS --
genes like me logo Genes that share ontologies with PTPRO: view

Pathways & Interactions for PTPRO Gene

genes like me logo Genes that share pathways with PTPRO: view

Pathways by source for PTPRO Gene

1 Qiagen pathway for PTPRO Gene

Gene Ontology (GO) - Biological Process for PTPRO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,TAS 10498613
GO:0007411 axon guidance ISS --
GO:0010812 negative regulation of cell-substrate adhesion ISS --
GO:0032835 glomerulus development IMP 21722858
GO:0035335 peptidyl-tyrosine dephosphorylation IEA,IMP 19233845
genes like me logo Genes that share ontologies with PTPRO: view

No data available for SIGNOR curated interactions for PTPRO Gene

Drugs & Compounds for PTPRO Gene

(1) Drugs for PTPRO Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for PTPRO Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTPRO: view

Transcripts for PTPRO Gene

Unigene Clusters for PTPRO Gene

Protein tyrosine phosphatase, receptor type, O:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRO Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1:
SP2: -
SP3: -
SP4:
SP5:

ExUns: 25a · 25b ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for PTPRO Gene

GeneLoc Exon Structure for
PTPRO
ECgene alternative splicing isoforms for
PTPRO

Expression for PTPRO Gene

mRNA expression in normal human tissues for PTPRO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRO Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.8) and Kidney - Cortex (x5.6).

Protein differential expression in normal tissues from HIPED for PTPRO Gene

This gene is overexpressed in Urine (55.9) and Pancreas (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTPRO Gene



SOURCE GeneReport for Unigene cluster for PTPRO Gene Hs.160871

mRNA Expression by UniProt/SwissProt for PTPRO Gene

Q16827-PTPRO_HUMAN
Tissue specificity: Glomerulus of kidney. Also detected in brain, lung and placenta.
genes like me logo Genes that share expression patterns with PTPRO: view

Protein tissue co-expression partners for PTPRO Gene

Primer Products

Orthologs for PTPRO Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRO 35
  • 91.15 (n)
  • 95.48 (a)
PTPRO 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRO 35
  • 91.83 (n)
  • 96.87 (a)
PTPRO 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpro 35
  • 85.22 (n)
  • 91.69 (a)
Ptpro 16
Ptpro 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPRO 35
  • 99.67 (n)
  • 100 (a)
PTPRO 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpro 35
  • 84.37 (n)
  • 91.12 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPRO 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRO 35
  • 79.03 (n)
  • 85.99 (a)
PTPRO 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRO 36
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lar 35
ptpro 35
  • 61.58 (n)
  • 60.29 (a)
ptpro 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 37
  • 36 (a)
Ptp10D 36
  • 17 (a)
ManyToMany
Ptp4E 36
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C17H12.3 37
  • 32 (a)
F36H12.10 37
  • 32 (a)
F47B3.1 37
  • 29 (a)
F47B3.6 37
  • 29 (a)
M04G7.2 37
  • 38 (a)
ZK616.7 37
  • 38 (a)
dep-1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
-- 36
  • 19 (a)
OneToMany
-- 36
  • 19 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 16 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 15 (a)
OneToMany
Species with no ortholog for PTPRO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPRO Gene

ENSEMBL:
Gene Tree for PTPRO (if available)
TreeFam:
Gene Tree for PTPRO (if available)

Paralogs for PTPRO Gene

(14) SIMAP similar genes for PTPRO Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PTPRO: view

Variants for PTPRO Gene

Sequence variations from dbSNP and Humsavar for PTPRO Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1981754 -- 15,597,829(+) ATAAT(A/G)TGTCG nc-transcript-variant, utr-variant-3-prime
rs2008652 -- 15,390,486(+) TCACT(A/T)TCACG intron-variant
rs2014097 -- 15,450,781(-) AAAAA(A/T)ttttt intron-variant
rs2014119 -- 15,450,930(-) ctttt(C/T)tttct intron-variant
rs2041896 -- 15,582,642(+) TAATT(A/G)GGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRO Gene

Variant ID Type Subtype PubMed ID
esv33461 CNV Gain 17666407
nsv622 CNV Loss 18451855
esv2745589 CNV Deletion 23290073
nsv470270 CNV Loss 18288195
nsv442257 CNV CNV 18776908
esv2421342 CNV Deletion 20811451
esv27762 CNV Loss 19812545
nsv498781 CNV Loss 21111241
esv2669816 CNV Deletion 23128226
esv2745590 CNV Deletion 23290073
nsv514655 CNV Loss 21397061
nsv517475 CNV Loss 19592680
esv271759 CNV Insertion 20981092
nsv898821 CNV Loss 21882294
esv2745591 CNV Deletion 23290073
esv1437894 CNV Deletion 17803354
nsv469121 CNV Loss 19166990

Variation tolerance for PTPRO Gene

Residual Variation Intolerance Score: 4.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRO Gene

Human Gene Mutation Database (HGMD)
PTPRO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRO Gene

Disorders for PTPRO Gene

MalaCards: The human disease database

(11) MalaCards diseases for PTPRO Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

UniProtKB/Swiss-Prot

PTPRO_HUMAN
  • Nephrotic syndrome 6 (NPHS6) [MIM:614196]: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. {ECO:0000269 PubMed:21722858}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PTPRO

Genetic Association Database (GAD)
PTPRO
Human Genome Epidemiology (HuGE) Navigator
PTPRO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRO
genes like me logo Genes that share disorders with PTPRO: view

No data available for Genatlas for PTPRO Gene

Publications for PTPRO Gene

  1. Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13. (PMID: 7665166) Wiggins R.C. … Thomas P.E. (Genomics 1995) 2 3 4 23 67
  2. Disruption of PTPRO causes childhood-onset nephrotic syndrome. (PMID: 21722858) Ozaltin F. … Bakkaloglu A. (Am. J. Hum. Genet. 2011) 2 3
  3. Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity. (PMID: 19095770) Ramaswamy B. … Jacob S.T. (Mol. Endocrinol. 2009) 3 23
  4. GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis. (PMID: 19233845) Gobert R.P. … Hooft van Huijsduijnen R. (J. Biol. Chem. 2009) 3 23
  5. Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia. (PMID: 17545520) Motiwala T. … Jacob S.T. (Clin. Cancer Res. 2007) 3 23

Products for PTPRO Gene

Sources for PTPRO Gene

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