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Aliases for PTPRO Gene

Aliases for PTPRO Gene

  • Protein Tyrosine Phosphatase, Receptor Type, O 2 3
  • GLEPP1 3 4 6
  • Osteoclastic Transmembrane Protein-Tyrosine Phosphatase 2 3
  • Glomerular Epithelial Protein 1 3 4
  • EC 4 63
  • PTPase U2 3 4
  • R-PTP-O 3 4
  • PTP-U2 3 4
  • PTPU2 3 4
  • NPHS6 3 6
  • Receptor-Type Tyrosine-Protein Phosphatase O 3
  • Protein Tyrosine Phosphatase PTP-U2 3
  • Protein Tyrosine Phosphatase U2 4
  • Phosphotyrosine Phosphatase U2 3
  • PTP Phi 3
  • PTP-OC 3
  • PTPROT 3

External Ids for PTPRO Gene

Previous GeneCards Identifiers for PTPRO Gene

  • GC12P015215
  • GC12P015620
  • GC12P015375
  • GC12P015476

Summaries for PTPRO Gene

Entrez Gene Summary for PTPRO Gene

  • This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]

GeneCards Summary for PTPRO Gene

PTPRO (Protein Tyrosine Phosphatase, Receptor Type, O) is a Protein Coding gene. Diseases associated with PTPRO include nephrotic syndrome, type 6 and familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation. Among its related pathways are PAK Pathway and Kit Receptor Signaling Pathway. GO annotations related to this gene include protein homodimerization activity and Wnt-protein binding. An important paralog of this gene is PTPRB.

UniProtKB/Swiss-Prot for PTPRO Gene

  • Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).

Gene Wiki entry for PTPRO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRO Gene

Genomics for PTPRO Gene

Regulatory Elements for PTPRO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPRO Gene

15,322,257 bp from pter
15,598,331 bp from pter
276,075 bases
Plus strand

Genomic View for PTPRO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRO Gene

Proteins for PTPRO Gene

  • Protein details for PTPRO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-type tyrosine-protein phosphatase O
    Protein Accession:
    Secondary Accessions:
    • A0AV39
    • Q13101
    • Q8IYG3
    • Q9UBF0
    • Q9UBT5

    Protein attributes for PTPRO Gene

    1216 amino acids
    Molecular mass:
    138344 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPRO Gene

    Alternative splice isoforms for PTPRO Gene


neXtProt entry for PTPRO Gene

Proteomics data for PTPRO Gene at MOPED

Selected DME Specific Peptides for PTPRO Gene

Post-translational modifications for PTPRO Gene

  • Glycosylation at Asn75, Asn154, Asn189, Asn201, Asn227, Asn278, Asn287, Asn323, Asn324, Asn370, Asn461, Asn490, Asn700, Asn712, and Asn733
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for PTPRO Gene

Gene Families for PTPRO Gene

  • FN3 :Fibronectin type III domain containing
  • PTPR :Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like

Graphical View of Domain Structure for InterPro Entry



  • Q16827
  • Contains 8 fibronectin type-III domains.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
genes like me logo Genes that share domains with PTPRO: view

Function for PTPRO Gene

Molecular function for PTPRO Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor type,U2 polypeptide,identical to PTPU2-LSB from glomerular epithelial podocyte membrane protein
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).
UniProtKB/Swiss-Prot Induction:
By various differentiation-inducing agents

Enzyme Numbers (IUBMB) for PTPRO Gene

Gene Ontology (GO) - Molecular Function for PTPRO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity TAS 10498613
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity NAS 7665166
GO:0005515 protein binding IPI 19167335
GO:0016791 phosphatase activity ISS --
GO:0017147 Wnt-protein binding ISS --
genes like me logo Genes that share ontologies with PTPRO: view
genes like me logo Genes that share phenotypes with PTPRO: view

Animal Models for PTPRO Gene

MGI Knock Outs for PTPRO:

Animal Model Products

miRNA for PTPRO Gene

miRTarBase miRNAs that target PTPRO

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRO

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PTPRO Gene

Localization for PTPRO Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRO Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PTPRO Gene COMPARTMENTS Subcellular localization image for PTPRO gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane NAS 7665166
GO:0016021 integral component of membrane TAS 10498613
GO:0016324 apical plasma membrane ISS --
GO:0016328 lateral plasma membrane ISS --
genes like me logo Genes that share ontologies with PTPRO: view

Pathways for PTPRO Gene

genes like me logo Genes that share pathways with PTPRO: view

Pathways by source for PTPRO Gene

1 Qiagen pathway for PTPRO Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPRO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis ISS --
GO:0002548 monocyte chemotaxis IMP 19233845
GO:0003093 regulation of glomerular filtration ISS --
GO:0003105 negative regulation of glomerular filtration ISS --
GO:0006470 protein dephosphorylation TAS 10498613
genes like me logo Genes that share ontologies with PTPRO: view

Compounds for PTPRO Gene

(2) HMDB Compounds for PTPRO Gene

Compound Synonyms Cas Number PubMed IDs
  • NFB Orthophosphate
  • Dihydrogen oxide

(2) Novoseek inferred chemical compound relationships for PTPRO Gene

Compound -log(P) Hits PubMed IDs
tyrosine 48.4 12
steroid 4.08 2
genes like me logo Genes that share compounds with PTPRO: view

Transcripts for PTPRO Gene

Unigene Clusters for PTPRO Gene

Protein tyrosine phosphatase, receptor type, O:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRO

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRO Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP2: -
SP3: -

ExUns: 25a · 25b ^ 26

Relevant External Links for PTPRO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPRO Gene

mRNA expression in normal human tissues for PTPRO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRO Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (5.8) and Kidney - Cortex (5.6).

Protein differential expression in normal tissues for PTPRO Gene

This gene is overexpressed in Urine (55.9) and Pancreas (11.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTPRO Gene

SOURCE GeneReport for Unigene cluster for PTPRO Gene Hs.160871

mRNA Expression by UniProt/SwissProt for PTPRO Gene

Tissue specificity: Glomerulus of kidney. Also detected in brain, lung and placenta.
genes like me logo Genes that share expressions with PTPRO: view

Expression partners for PTPRO Gene

In Situ Assay Products

Orthologs for PTPRO Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRO Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PTPRO 35
  • 91.15 (n)
  • 95.48 (a)
  • 94 (a)
(Canis familiaris)
Mammalia PTPRO 35
  • 91.83 (n)
  • 96.87 (a)
  • 97 (a)
(Mus musculus)
Mammalia Ptpro 35
  • 85.22 (n)
  • 91.69 (a)
Ptpro 16
Ptpro 36
  • 91 (a)
(Pan troglodytes)
Mammalia PTPRO 35
  • 99.67 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ptpro 35
  • 84.37 (n)
  • 91.12 (a)
(Monodelphis domestica)
Mammalia PTPRO 36
  • 88 (a)
(Gallus gallus)
Aves PTPRO 35
  • 79.03 (n)
  • 85.99 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia PTPRO 36
  • 83 (a)
(Danio rerio)
Actinopterygii lar 35
ptpro 35
  • 61.58 (n)
  • 60.29 (a)
ptpro 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 37
  • 36 (a)
Ptp10D 36
  • 17 (a)
Ptp4E 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea C17H12.3 37
  • 32 (a)
F36H12.10 37
  • 32 (a)
F47B3.1 37
  • 29 (a)
F47B3.6 37
  • 29 (a)
M04G7.2 37
  • 38 (a)
ZK616.7 37
  • 38 (a)
dep-1 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
-- 36
  • 19 (a)
-- 36
  • 19 (a)
-- 36
  • 18 (a)
-- 36
  • 16 (a)
-- 36
  • 18 (a)
-- 36
  • 18 (a)
-- 36
  • 15 (a)
Species with no ortholog for PTPRO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPRO Gene

Gene Tree for PTPRO (if available)
Gene Tree for PTPRO (if available)

Paralogs for PTPRO Gene

Paralogs for PTPRO Gene

Selected SIMAP similar genes for PTPRO Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PTPRO: view

Variants for PTPRO Gene

Sequence variations from dbSNP and Humsavar for PTPRO Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs105730 -- 15,477,280(+) ctcac(A/T)catag intron-variant
rs117030 -- 15,466,307(+) GCGCA(A/G)GAAGT intron-variant
rs166201 -- 15,456,850(+) tttcc(A/G)cagtt intron-variant
rs187582 -- 15,475,574(+) ATTCC(A/G)AATAA intron-variant
rs253792 -- 15,452,871(+) CAACA(C/T)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRO Gene

Variant ID Type Subtype PubMed ID
esv33461 CNV Gain 17666407
nsv622 CNV Loss 18451855
esv2745589 CNV Deletion 23290073
nsv470270 CNV Loss 18288195
nsv442257 CNV CNV 18776908
esv2421342 CNV Deletion 20811451
esv27762 CNV Loss 19812545
nsv498781 CNV Loss 21111241
esv2669816 CNV Deletion 23128226
esv2745590 CNV Deletion 23290073
nsv514655 CNV Loss 21397061
nsv517475 CNV Loss 19592680
esv271759 CNV Insertion 20981092
nsv898821 CNV Loss 21882294
esv2745591 CNV Deletion 23290073
esv1437894 CNV Deletion 17803354
nsv469121 CNV Loss 19166990

Relevant External Links for PTPRO Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRO Gene

Disorders for PTPRO Gene

(1) OMIM Diseases for PTPRO Gene (600579)


  • Nephrotic syndrome 6 (NPHS6) [MIM:614196]: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. {ECO:0000269 PubMed:21722858}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for PTPRO Gene

(9) Novoseek inferred disease relationships for PTPRO Gene

Disease -log(P) Hits PubMed IDs
glomerulosclerosis, focal segmental 63.8 1
glomerulosclerosis 53.3 1
wilms tumor 52.5 4
nephrotic syndrome 46.2 2
proteinuria 41.9 2

Relevant External Links for PTPRO

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PTPRO: view

No data available for Genatlas for PTPRO Gene

Publications for PTPRO Gene

  1. Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13. (PMID: 7665166) Wiggins R.C. … Thomas P.E. (Genomics 1995) 2 3 4 23
  2. PTPROt: an alternatively spliced and developmentally regulated B- lymphoid phosphatase that promotes G0/G1 arrest. (PMID: 10498613) Aguiar R.C. … Shipp M.A. (Blood 1999) 3 4 23
  3. Disruption of PTPRO causes childhood-onset nephrotic syndrome. (PMID: 21722858) Ozaltin F. … Bakkaloglu A. (Am. J. Hum. Genet. 2011) 2 3 4
  4. Genome-wide study identifies PTPRO and WDR72 and FOXQ1-SUMO1P1 interaction associated with neurocognitive function. (PMID: 22126837) LeBlanc M. … Andreassen O.A. (J Psychiatr Res 2012) 3 48
  5. Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. (PMID: 15356345) Motiwala T. … Jacob S.T. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 23

Products for PTPRO Gene

Sources for PTPRO Gene

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