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PTPRO Gene

protein-coding   GIFtS: 66
GCID: GC12P015476

Protein Tyrosine Phosphatase, Receptor Type, O

  See PTPRO-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Receptor Type, O1 2     NPHS62 5
GLEPP12 3 5     PTP-OC2
Osteoclastic Transmembrane Protein-Tyrosine Phosphatase1 2     PTPROT2
Glomerular Epithelial Protein 12 3     Phosphotyrosine Phosphatase U22
PTP-U22 3     Protein Tyrosine Phosphatase PTP-U22
PTPU22 3     PTP Phi2
R-PTP-O2 3     Receptor-Type Tyrosine-Protein Phosphatase O2
PTPase U22 3     Protein Tyrosine Phosphatase U23
EC 3.1.3.483 8     

External Ids:    HGNC: 96781   Entrez Gene: 58002   Ensembl: ENSG000001514907   OMIM: 6005795   UniProtKB: Q168273   

Export aliases for PTPRO gene to outside databases

Previous GC identifers: GC12P015215 GC12P015620 GC12P015375 GC12P015366


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPRO Gene:
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins
are localized to the apical surface of polarized cells and may have tissue-specific functions through activation
of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants
encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and
tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell
proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression
of this gene has been observed in several types of cancer. (provided by RefSeq, May 2011)

GeneCards Summary for PTPRO Gene:
PTPRO (protein tyrosine phosphatase, receptor type, O) is a protein-coding gene. Diseases associated with PTPRO include nephrotic syndrome, type 6, and familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation. GO annotations related to this gene include Wnt-protein binding and protein homodimerization activity. An important paralog of this gene is PTPRQ.

UniProtKB/Swiss-Prot: PTPRO_HUMAN, Q16827
Function: Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration
rate relationship through an effect on podocyte structure and function (By similarity)

Gene Wiki entry for PTPRO Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPRO gene promoter:
         TBP   Lmo2   Tal-1beta   Evi-1   AREB6   POU2F1   FOXC1   POU2F1a   HSF2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPRO promoter sequence
   Search Chromatin IP Primers for PTPRO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPRO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3-p13.2|12p13-p12   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p13-p12

PTPRO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRO gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P015476:  view genomic region     (about GC identifiers)

Start:
15,475,191 bp from pter      End:
15,751,265 bp from pter
Size:
276,075 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PTPRO_HUMAN, Q16827 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein phosphatase O precursor  
Size: 1216 amino acids; 138344 Da
2 PDB 3D structures from and Proteopedia for PTPRO:
2G59 (3D)        2GJT (3D)    
Secondary accessions: A0AV39 Q13101 Q9UBF0 Q9UBT5
Alternative splicing: 4 isoforms:  Q16827-1   Q16827-2   Q16827-3   Q16827-4   (Predominantly expressed in B-lymphoid tissues)

Explore the universe of human proteins at neXtProt for PTPRO: NX_Q16827

Explore proteomics data for PTPRO at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn75, Asn154, Asn189, Asn201, Asn227, Asn278, Asn287, Asn323, Asn324, Asn370,
                                 Asn461, Asn490, Asn700, Asn712, Asn733
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for PTPRO (Q16827)
     VQTEEQY  WPDHGVP  DYINANY  YIATQGP 


    See PTPRO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_002839.1  NP_109592.1  NP_109593.1  NP_109594.1  NP_109595.1  NP_109596.1  

    ENSEMBL proteins: 
     ENSP00000281171   ENSP00000444173   ENSP00000343434   ENSP00000404188   ENSP00000437571  
     ENSP00000393449   ENSP00000439234   ENSP00000445621   ENSP00000446201  

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    Cloud-Clone Corp. Proteins for PTPRO

     
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    Search eBioscience for ELISAs for PTPRO 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    PTPR: Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like

    IUPHAR Guide to PHARMACOLOGY protein family classification: Type O
    Receptor tyrosine phosphatases (RTP)

    5 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR016130 Tyr_Pase_AS
     IPR013783 Ig-like_fold
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry Q16827

    ProtoNet protein and cluster: Q16827

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTPRO_HUMAN, Q16827
    Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily
    Similarity: Contains 8 fibronectin type-III domains
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPRO           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTPRO_HUMAN, Q16827
    Function: Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration
    rate relationship through an effect on podocyte structure and function (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Induction: By various differentiation-inducing agents

         Genatlas biochemistry entry for PTPRO:
    protein tyrosine phosphatase,receptor type,U2 polypeptide,identical to PTPU2-LSB from glomerular epithelial
    podocyte membrane protein

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity TAS10498613
    GO:0005001transmembrane receptor protein tyrosine phosphatase activity NAS7665166
    GO:0005515protein binding IPI19167335
    GO:0016791phosphatase activity ISS--
    GO:0017147Wnt-protein binding ISS--
         
    Find genes that share ontologies with PTPRO           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PTPRO:
     Increased apoptosis  Stronger migration 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ptpro):
     behavior/neurological  cardiovascular system  nervous system  normal  renal/urinary system 

    Find genes that share phenotypes with PTPRO           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTPRO: Ptprotm1Shs Ptprotm1Wig

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTPRO
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPRO
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPRO

    miRNA
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    miRTarBase miRNAs that target PTPRO:
    hsa-mir-26b-5p (MIRT029550), hsa-mir-17-5p (MIRT000977)

    Block miRNA regulation of human, mouse, rat PTPRO using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPRO (see all 58):
    hsa-miR-4317 hsa-miR-1321 hsa-let-7d hsa-miR-106a hsa-miR-513a-5p hsa-miR-4272 hsa-miR-25 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidPTPRO 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PTPRO
    Predesigned siRNA for gene silencing in human, mouse, rat PTPRO

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 6): PTPRO (NM_002848)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRO

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    eBioscience FlowRNA Probe Sets ( VA4-12615) for PTPRO 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTPRO_HUMAN, Q16827: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ISS--
    GO:0005887integral component of plasma membrane NAS7665166
    GO:0016021integral component of membrane TAS10498613
    GO:0016324apical plasma membrane ISS--
    GO:0016328lateral plasma membrane ISS--

    Find genes that share ontologies with PTPRO           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPRO About    
    See pathways by source

    SuperPathContained pathways About
    1Kit Receptor Signaling Pathway
    Signaling events mediated by Stem cell factor receptor (c-Kit)0.37
    2PAK Pathway
    Epithelial Adherens Junctions0.36

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPRO
        Epithelial Adherens Junctions

    1 BioSystems Pathway for PTPRO
        Signaling events mediated by Stem cell factor receptor (c-Kit)


        Pathway & Disease-focused RT2 Profiler PCR Array including PTPRO: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPRO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTPRO (Q168271, 2, 3 ENSP000002811714) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPPA4Q7L1902, 3, ENSP000003353064MINT-8267654 I2D: score=2 STRING: ENSP00000335306
    ERBB2P046261, 3, ENSP000002695714EBI-723739,EBI-641062 I2D: score=1 STRING: ENSP00000269571
    TEKQ027631, 3, ENSP000003839774EBI-723739,EBI-2257090 I2D: score=1 STRING: ENSP00000383977
    SH3GL3Q999632, 3MINT-8267687 I2D: score=2 
    DPYSL4O145312, 3, ENSP000003398504MINT-8267665 I2D: score=2 STRING: ENSP00000339850
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ISS--
    GO:0002548monocyte chemotaxis IMP19233845
    GO:0003093regulation of glomerular filtration ISS--
    GO:0003105negative regulation of glomerular filtration ISS--
    GO:0006470protein dephosphorylation TAS10498613

    Find genes that share ontologies with PTPRO           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPRO

    2 HMDB Compounds for PTPRO    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 Novoseek inferred chemical compound relationships for PTPRO gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 48.4 19 7665166 (2), 15356345 (2), 20163174 (1), 9639039 (1) (see all 10)
    steroid 4.08 2 16564554 (2)



    Find genes that share compounds with PTPRO           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTPRO gene (6 alternative transcripts): 
    NM_002848.3  NM_030667.2  NM_030668.2  NM_030669.2  NM_030670.2  NM_030671.2  

    Unigene Cluster for PTPRO:

    Protein tyrosine phosphatase, receptor type, O
    Hs.160871  [show with all ESTs]
    Unigene Representative Sequence: NM_030667
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281171(uc001rcu.2 uc001rcv.2 uc001rcw.2) ENST00000543886
    ENST00000348962 ENST00000545023 ENST00000442921(uc001rcx.2) ENST00000542557(uc001rcz.2)
    ENST00000445537(uc001rcy.2) ENST00000544244(uc001rda.2) ENST00000535311
    ENST00000538907 ENST00000535322 ENST00000544706
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PTPRO (see all 58):
    hsa-miR-4317 hsa-miR-1321 hsa-let-7d hsa-miR-106a hsa-miR-513a-5p hsa-miR-4272 hsa-miR-25 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidPTPRO 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat PTPRO
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRO
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      QuantiFast Probe-based Assays in human, mouse, rat PTPRO
    Flow Cytometry
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    Additional mRNA sequence: 

    AB209729.1 AF152378.1 AF187042.1 AF187043.1 AF187044.1 AK289784.1 AK290982.1 AK299529.1 
    BC035960.1 BC126201.1 BC126203.1 Z48541.1 

    12 DOTS entries:

    DT.100779477  DT.114661  DT.92425999  DT.100779476  DT.95370076  DT.92426000  DT.75102288  DT.121182178 
    DT.100679197  DT.121167568  DT.70103348  DT.95187182 

    Selected AceView cDNA sequences (see all 105):

    Z40306 BE552000 AI274111 AW161374 NM_030669 NM_002848 AA564303 AF187044 
    AI917679 AU132750 AI992014 BU742554 NM_030667 BQ955673 U20489 BF430950 
    AF187043 NM_030668 AI672002 BE463996 Z44372 BC035960 NM_030671 CA307297 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PTPRO    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                        -                                                   
    SP3:                                                              -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25a · 25b ^ 26
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for PTPRO

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PTPRO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATATACAAC
    PTPRO Expression
    About this image


    PTPRO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Presumptive Podocytes Podocyte Layer
             S-shaped Body
             Renal-like cells
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             Midbrain dopaminergic-like neurons
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    PTPRO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPRO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.160871

    UniProtKB/Swiss-Prot: PTPRO_HUMAN, Q16827
    Tissue specificity: Glomerulus of kidney. Also detected in brain, lung and placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including PTPRO: 
              Protein Phosphatases in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTPRO gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpro1 , 5 protein tyrosine phosphatase, receptor type, O1, 5 85.22(n)1
    91.69(a)1
      6 (66.75 cM)5
    192771  NM_011216.31  NP_035346.31 
     1372522995 
    chicken
    (Gallus gallus)
    Aves PTPRO1 protein tyrosine phosphatase, receptor type, O 79.03(n)
    85.99(a)
      373911  NM_204122.1  NP_989453.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTPRO6
    protein tyrosine phosphatase, receptor type, O
    83(a)
    1 ↔ 1
    GL343336.1(1056380-1183015)
    zebrafish
    (Danio rerio)
    Actinopterygii lar2 Transcribed sequence with moderate similarity to protein more 75.99(n)    BQ419732.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ptp52F3 axon guidance protein tyrosine
    phosphatase
    36(a)   52F3   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK616.73   -- 38(a)
    (best of 6)
      IV(5408618-5409621)   --


    ENSEMBL Gene Tree for PTPRO (if available)
    TreeFam Gene Tree for PTPRO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPRO gene
    PTPRQ2  PTPRJ2  PTPN72  PTPRH2  PTPN52  PTPRB2  PTPRR2  
    14 SIMAP similar genes for PTPRO using alignment to 4 protein entries:     PTPRO_HUMAN (see all proteins):
    PTPRM    PTPN1    PTPN2    PTPN7    PTPRR    BPTP-2
    PTN2    PTPN20A    PTPN20B    PTPRQ    PTPRD    PTPN12
    BPTP-3    PTPN4

    Find genes that share paralogs with PTPRO           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPRO (see all 5663)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497810741,2
    --15342210(+) AGAAAC/TTGTTG 2 -- us2k10--------
    rs557651541,2
    C,F--15342234(+) GTGATT/CGTTGC 2 -- us2k11Minor allele frequency- C:0.04NA 120
    rs1441199551,2
    --15342239(+) TGTTGC/TCCTTG 2 -- us2k10--------
    rs2001486591,2
    C--15342284(+) ACTTTA/CCAGCC 2 -- us2k10--------
    rs1895785371,2
    --15342330(+) AGGAGC/TGTCAA 2 -- us2k10--------
    rs1399828271,2
    --15342486(+) AGTGGA/GCATGA 2 -- us2k10--------
    rs1808135121,2
    --15342583(+) TCAGAC/TCATCA 2 -- us2k10--------
    rs1167989481,2
    C,F--15342645(+) TTTGGT/CACATA 2 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1866437651,2
    --15342657(+) ATACAC/TATATG 2 -- us2k10--------
    rs1893737771,2
    --15342674(+) GCATAA/TACATA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTPRO (15475191 - 15725191 bp, first 250kb of PTPRO)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTPRO (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669816CNV Deletion23128226
    esv2745589CNV Deletion23290073
    esv2745591CNV Deletion23290073
    esv1437894CNV Deletion17803354
    esv2421342CNV Deletion20811451
    esv2745590CNV Deletion23290073
    esv271759CNV Insertion20981092
    nsv622CNV Loss18451855
    esv27762CNV Loss19812545
    nsv470270CNV Loss18288195

    Human Gene Mutation Database (HGMD): PTPRO
    4 Site Specific Mutation Identification with PCR Assays for PTPRO:
    Cosmic IdAA Change
    107474p.S280Y
    109418p.E854K
    108504p.R1122*
    107957p.F938L
    SeqTarget long-range PCR primers for resequencing PTPRO
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPRO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600579   
    OMIM disorders: 614196  
    UniProtKB/Swiss-Prot: PTPRO_HUMAN, Q16827
  • Nephrotic syndrome 6 (NPHS6) [MIM:614196]: A form of nephrotic syndrome, a renal disease clinically
    characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and
    edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and
    diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress
    to end-stage renal failure. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 6 diseases for PTPRO:    
    About MalaCards
    nephrotic syndrome, type 6    familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation    familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis    familial idiopathic steroid-resistant nephrotic syndrome with minimal changes
    nephrotic syndrome    familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis

    1 disease from the University of Copenhagen DISEASES database for PTPRO:
    Glomerulonephritis

    Find genes that share disorders with PTPRO           About GenesLikeMe

    9 Novoseek inferred disease relationships for PTPRO gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glomerulosclerosis, focal segmental 63.8 1 16564554 (1)
    glomerulosclerosis 53.3 1 9639039 (1)
    wilms tumor 52.5 5 14569107 (2), 11158216 (1), 14531804 (1)
    nephrotic syndrome 46.2 2 9639039 (2)
    proteinuria 41.9 2 16564554 (1), 17593862 (1)
    lung tumor 38 2 17545520 (1), 15356345 (1)
    renal disease 7.29 4 17593862 (2), 9639039 (1)
    tumors 0 6 15803146 (2), 15356345 (2), 17545520 (1), 19095770 (1)
    cancer 0 1 15803146 (1)

    Genetic Association Database (GAD): PTPRO
    Human Genome Epidemiology (HuGE) Navigator: PTPRO (7 documents)

    Export disorders for PTPRO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPRO gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with PTPRO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13. (PubMed id 7665166)1, 2, 3, 9 Wiggins R.C.... Thomas P.E. (Genomics 1995)
    2. Disruption of PTPRO causes childhood-onset nephrotic syndrome. (PubMed id 21722858)1, 2, 3 Ozaltin F.... Bakkaloglu A. (Am. J. Hum. Genet. 2011)
    3. PTPROt: an alternatively spliced and developmentally regulated B- lymphoid phosphatase that promotes G0/G1 arrest. (PubMed id 10498613)1, 2, 9 Aguiar R.C....Shipp M.A. (Blood 1999)
    4. Genome-wide study identifies PTPRO and WDR72 and FOXQ1-SUMO1P1 interaction associated with neurocognitive function. (PubMed id 22126837)1, 4 LeBlanc M....Andreassen O.A. (J Psychiatr Res 2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    8. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)1, 2 Barr A.J.... Knapp S. (Cell 2009)
    9. Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents. (PubMed id 7753550)1, 2 Seimiya H.... Tsuruo T. (Oncogene 1995)
    10. Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity. (PubMed id 19095770)1, 9 Ramaswamy B....Jacob S.T. (Mol. Endocrinol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5800 HGNC: 9678 AceView: PTPRO Ensembl:ENSG00000151490 euGenes: HUgn5800
    ECgene: PTPRO H-InvDB: PTPRO

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPRO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPRO gene:
    Search GeneIP for patents involving PTPRO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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