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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PTPRO Gene

protein-coding GIFtS: 65
GCID: GC12P015375

protein tyrosine phosphatase, receptor type, O

Explore 24 diseases affiliated with
PTPRO via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Receptor Type, O¹ ²		PTP-Oc¹
GLEPP1¹ ² ³ ⁵		PTP-OC²
PTP-U2¹ ² ³		PTPROT²
PTPU2¹ ² ³		Osteoclastic Transmembrane Protein-Tyrosine Phosphatase²
NPHS6¹ ²		Phosphotyrosine Phosphatase U2²
Glomerular Epithelial Protein 1² ³		Protein Tyrosine Phosphatase PTP-U2²
R-PTP-O² ³		PTP Phi²
PTPase U2² ³		Receptor-Type Tyrosine-Protein Phosphatase O²
EC 3.1.3.48³ ⁸		Protein Tyrosine Phosphatase U2³

External Ids:	HGNC: 9678¹	Entrez Gene: 5800²	Ensembl: ENSG00000151490⁷	OMIM: 600579⁵	UniProtKB: Q16827³

Export aliases for PTPRO gene to outside databases

Previous GC identifers: GC12P015215 GC12P015620 GC12P015366

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPRO:

This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are

localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src

family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding

multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific

functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and

facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been

observed in several types of cancer. (provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: PTPRO_HUMAN, Q16827

Function: Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate

relationship through an effect on podocyte structure and function (By similarity)

Gene Wiki entry for PTPRO

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTPRO gene promoter:
TBP Lmo2 Tal-1beta Evi-1 AREB6 POU2F1 FOXC1 POU2F1a HSF2 ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTPRO promoter sequence

Search SABiosciences Chromatin IP Primers for PTPRO

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPRO

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3-p13.2|12p13-p12 Ensembl cytogenetic band: 12p12.3 HGNC cytogenetic band: 12p13-p12

PTPRO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRO gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P015375: view genomic region (about GC identifiers)

Start:	15,475,331 bp from pter	End:	15,750,335 bp from pter
Size:	275,005 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PTPRO_HUMAN, Q16827 (See protein sequence)

Recommended Name: Receptor-type tyrosine-protein phosphatase O precursor

Size: 1216 amino acids; 138344 Da

Subcellular location: Membrane; Single-pass type I membrane protein

2 PDB 3D structures from and Proteopedia for PTPRO:

2G59 (3D)

2GJT (3D)

Secondary accessions: A0AV39 Q13101 Q9UBF0 Q9UBT5

Alternative splicing: 4 isoforms: Q16827-1 Q16827-2 Q16827-3 Q16827-4 (Predominantly expressed in B-lymphoid tissues)

Explore the universe of human proteins at neXtProt for PTPRO: NX_Q16827

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16827

4 DME Specific Peptides for PTPRO (Q16827)

VQTEEQY

WPDHGVP

DYINANY

YIATQGP

PTPRO Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_002839.1 NP_109592.1 NP_109593.1 NP_109594.1 NP_109595.1 NP_109596.1

ENSEMBL proteins:

ENSP00000281171 ENSP00000444173 ENSP00000343434 ENSP00000404188 ENSP00000437571

ENSP00000393449 ENSP00000439234 ENSP00000445621 ENSP00000446201

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Proteins (see all 2): PTPRO OriGene Protein Over-expression Lysate (see all 6): PTPRO OriGene Custom Protein Services for PTPRO
	GenScript Custom Purified and Recombinant Proteins Services for PTPRO
	Novus Biologicals PTPRO Proteins Novus Biologicals PTPRO Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PTPRO

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	ISS	--
GO:0005887	integral to plasma membrane	NAS	7665166
GO:0016021	integral to membrane	TAS	10498613
GO:0016324	apical plasma membrane	ISS	--
GO:0016328	lateral plasma membrane	ISS	--

PTPRO for ontologies About GeneDecksing

PTPRO Antibody Products:

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	GenScript Custom Superior Antibodies Services for PTPRO
	Novus Biologicals PTPRO Antibodies
	Search for Antibodies for PTPRO at Abcam
	Uscn Antibodies for PTPRO
	ThermoFisher Antibodies for PTPRO

Assay Products for PTPRO:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PTPRO
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PTPRO

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTPRO for domains About GeneDecksing

5 InterPro domains/families:

IPR003961 Fibronectin_type3

IPR016130 Tyr_Pase_AS

IPR013783 Ig-like_fold

IPR000242 Tyr_Pase_rcpt/non-rcpt

IPR000387 Tyr/Dual-sp_Pase

Graphical View of Domain Structure for InterPro Entry Q16827

ProtoNet protein and cluster: Q16827

1 Blocks protein family: IPB000242 Protein tyrosine phosphatase signature

UniProtKB/Swiss-Prot: PTPRO_HUMAN, Q16827

Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily

Similarity: Contains 8 fibronectin type-III domains

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PTPRO_HUMAN, Q16827

Function: Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate

relationship through an effect on podocyte structure and function (By similarity)

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Induction: By various differentiation-inducing agents

Genatlas biochemistry entry for PTPRO:

protein tyrosine phosphatase,receptor type,U2 polypeptide,identical to PTPU2-LSB from glomerular epithelial podocyte

membrane protein

Enzyme Number (IUBMB): EC 3.1.3.48¹ ²

miRNA Products:		miRTarBase miRNAs that target PTPRO: hsa-mir-17 (MIRT000977)

		OriGene 3'-UTR Clone (see all 6): PTPRO Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPRO
		8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPRO (see all 58):
		hsa-miR-4317 hsa-miR-1321 hsa-let-7d hsa-miR-106a hsa-miR-513a-5p hsa-miR-4272 hsa-miR-25 hsa-miR-4267

		SwitchGear 3'UTR luciferase reporter plasmid: PTPRO 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPRO (see all 7) OriGene shRNA RFP: PTPRO OriGene siRNA: PTPRO
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPRO

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PTPRO

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRO (see all 11) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRO (see all 6) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): PTPRO (NM_002848)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPRO
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRO

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PTPRO
		Search LifeMap BioReagents cell lines for PTPRO

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRO

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004725	protein tyrosine phosphatase activity	TAS	10498613
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	NAS	7665166
GO:0005515	protein binding	IPI	19167335
GO:0016791	phosphatase activity	ISS	--
GO:0017147	Wnt-protein binding	ISS	--

PTPRO for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PTPRO:

Increased apoptosis

Stronger migration

Animal Models:
Mouse knock-out Ptpro^tm1Wig for PTPRO
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ptpro):

behavior/neurological

cardiovascular system

nervous system

renal/urinary system

PTPRO for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling events mediated by Stem cell factor receptor (c-Kit)

Signaling events mediated by Stem cell factor receptor (c-Kit)

1.00

PAK Pathway

Epithelial Adherens Junctions

0.36

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPRO

Epithelial Adherens Junctions

1 BioSystems Pathway for PTPRO

Signaling events mediated by Stem cell factor receptor (c-Kit)

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTPRO

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/31 Interacting proteins for PTPRO (Q16827^{1, 2, 3} ENSP00000281171⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPPA4	Q7L190²^,³, ENSP00000335306⁴	MINT-8267654 I2D: score=2 STRING: ENSP00000335306
ERBB2	P04626¹^,³, ENSP00000269571⁴	EBI-723739,EBI-641062 I2D: score=1 STRING: ENSP00000269571
TEK	Q02763¹^,³, ENSP00000383977⁴	EBI-723739,EBI-2257090 I2D: score=1 STRING: ENSP00000383977
SH3GL3	Q99963²^,³	MINT-8267687 I2D: score=2
DPYSL4	O14531²^,³, ENSP00000339850⁴	MINT-8267665 I2D: score=2 STRING: ENSP00000339850

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000902	cell morphogenesis	ISS	--
GO:0002548	monocyte chemotaxis	IMP	19233845
GO:0003093	regulation of glomerular filtration	ISS	--
GO:0003105	negative regulation of glomerular filtration	ISS	--
GO:0006470	protein dephosphorylation	TAS	10498613

PTPRO for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PTPRO for compounds About GeneDecksing

EMD Millipore small molecules for PTPRO:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PTPRO

2 HMDB Compounds for PTPRO About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

2 Novoseek chemical compound relationships for PTPRO gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	48.4	19	7665166 (2), 15356345 (2), 20163174 (1), 9639039 (1) (see all 10)
steroid	4.08	2	16564554 (2)

Search CenterWatch for drugs/clinical trials and news about PTPRO

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PTPRO gene (6 alternative transcripts):

NM_002848.3 NM_030667.2 NM_030668.2 NM_030669.2 NM_030670.2 NM_030671.2

Unigene Cluster for PTPRO:

Protein tyrosine phosphatase, receptor type, O

Hs.160871 [show with all ESTs]

Unigene Representative Sequence: NM_030667

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000281171(uc001rcu.2 uc001rcv.2 uc001rcw.2) ENST00000543886

ENST00000348962 ENST00000545023 ENST00000442921(uc001rcx.2) ENST00000542557(uc001rcz.2)

ENST00000445537(uc001rcy.2) ENST00000544244(uc001rda.2) ENST00000535311

ENST00000538907 ENST00000535322 ENST00000544706

miRNA Products:		OriGene 3'-UTR Clone (see all 6): PTPRO Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPRO
		8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPRO (see all 58):
		hsa-miR-4317 hsa-miR-1321 hsa-let-7d hsa-miR-106a hsa-miR-513a-5p hsa-miR-4272 hsa-miR-25 hsa-miR-4267

		SwitchGear 3'UTR luciferase reporter plasmid: PTPRO 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPRO (see all 7) OriGene shRNA RFP: PTPRO OriGene siRNA: PTPRO
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPRO

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRO (see all 11) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRO (see all 6) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): PTPRO (NM_002848)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPRO
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRO

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPRO Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTPRO
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPRO
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPRO

Additional cDNA sequence:

AB209729.1 AF152378.1 AF187042.1 AF187043.1 AF187044.1 AK289784.1 AK290982.1 AK299529.1

BC035960.1 BC126201.1 BC126203.1 Z48541.1

11 DOTS entries:

DT.100779477 DT.114661 DT.92425999 DT.95370076 DT.100779476 DT.92426000 DT.75102288 DT.121182178

DT.100679197 DT.121167568 DT.70103348

24/105 AceView cDNA sequences (see all 105):

Z40306 AW161374 AA564303 AF187044 NM_002848 AI992014 AU132750 BU742554

NM_030667 NM_030669 AI917679 BE552000 AI274111 BM728530 CA307297 NM_030671

AI672002 BE463996 BC035960 Z44372 NM_030668 BQ955673 BF430950 U20489

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for PTPRO About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^
SP1:
SP2:																																			-
SP3:																					-
SP4:
SP5:

ExUns:	25a	·	25b	^	26
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PTPRO

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PTPRO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATATACAAC

About this image

PTPRO expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Podocyte Layer

Podocytes

Kidney

Podocyte Layer

Presumptive Podocytes

Kidney

Brain

Brain

Brain

Kidney

Kidney

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Renal-like cells (Derivation of renal-...)

Midbrain dopaminergic-like neurons (Generation of midbra...)

Nkx2-1 GFP+ cells (Efficient derivation...)

See PTPRO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTPRO

SOURCE GeneReport for Unigene cluster: Hs.160871

UniProtKB/Swiss-Prot: PTPRO_HUMAN, Q16827

Tissue specificity: Glomerulus of kidney. Also detected in brain, lung and placenta

SABiosciences Expression via Pathway-Focused PCR Array including PTPRO:

Protein Phosphatases in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPRO Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTPRO
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPRO
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPRO

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRO

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PTPRO gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PTPRO¹	protein tyrosine phosphatase, receptor type, O	78.81(n) 85.63(a)		373911 NM_204122.1 NP_989453.1
lizard (Anolis carolinensis)	Reptilia	PTPRO⁶	--	83(a)	1 ↔ 1	GL343336.1(1056396-1114151)
zebrafish (Danio rerio)	Actinopterygii	lar²	Transcribed sequence with moderate similarity to protein more	75.99(n)		BQ419732.1
fruit fly (Drosophila melanogaster)	Insecta	Ptp52F³	axon guidance protein tyrosine phosphatase	36(a)		52F3 --
thale cress (Arabidopsis thaliana)	eudicotyledons	ATPTP1⁶	tyrosine phosphatase 1	26(a)	1 → many	1(27026711-27029092)
rice (Oryza sativa)	Liliopsida	-- --	Protein-tyrosine phosphatase domain containing pro... Protein-tyrosine phosphatase domain containing pro...	24(a) 22(a)	many ↔ many many ↔ many	12(3791109-3796496) 11(4000708-4008336)

ENSEMBL Gene Tree for PTPRO (if available)
TreeFam Gene Tree for PTPRO (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PTPRO gene

PTPN7² PTPRH² PTPN22² PTPN11² PTPN6² PTPRJ² PTPRQ² PTPN18²

PTPN12² PTPN5² PTPRB² PTPRR²

13 SIMAP similar genes for PTPRO using alignment to 4 protein entries: PTPRO_HUMAN (see all proteins):

PTPRM PTPN1 PTPN2 PTPN7 PTPRR BPTP-2

PTPN20A PTPN20B PTPRQ PTPRD PTPN12 BPTP-3

PTPN4

PTPRO for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs55765154^1,2	C,F,	--	15242526(+)	`GTGATT/CGTTGC`	2	--	us2k¹		1		NA	120
rs200148659^1,2	C	--	15242576(+)	`ACTTTA/CCAGCC`	2	--	us2k¹		0	--	--	--	--
rs79141228^1,2		--	15243177(+)	`TATTCA/GATCTA`	2	--	us2k¹		0	--	--	--	--
rs11829248^1,2	C,F,H	--	15243388(+)	`TCTCAG/AGTATA`	2	--	us2k¹		4		NS NA	184
rs11836975^1,2	C,F,H,	--	15243543(+)	`TAGATT/CGGGGA`	2	--	us2k¹		6		NS EA NA WA	538
rs79685694^1,2		--	15243853(+)	`AGAAAA/GCCATA`	2	--	us2k¹		0	--	--	--	--
rs75976491^1,2	F,	--	15247116(+)	`GTGCGT/CTGGGC`	2	--	int¹		1		NA	120
rs58421337^1,2	C,	--	15247876(+)	`AGCCTC/TGCTGT`	2	--	int¹		1		WA	2
rs11056430^1,2	C,F,H	--	15248134(+)	`TTTTAA/CCCCCT`	2	--	int¹		5		NS EA NA	420
rs77897575^1,2		--	15249126(+)	`TTTCAC/TTTAAT`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PTPRO (15475331 - 15725331 bp, first 250kb of PTPRO)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for PTPRO
9 CNVs: 66147 38256 49011 35065 6971 86235 86234 49013 49012
Human Gene Mutation Database (HGMD): PTPRO

4 SABiosciences Cancer Mutation PCR Assays for PTPRO:

Cosmic Id	AA Change
107474	p.S280Y
109418	p.E854K
108504	p.R1122*
107957	p.F938L

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPRO

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PTPRO for disorders About GeneDecksing

OMIM gene information: 600579 OMIM disorders: --

UniProtKB/Swiss-Prot: PTPRO_HUMAN, Q16827

Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6) [MIM:614196]. NPHS6 is a renal disease

characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific

histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected

individuals have an inherited steroid-resistant form and progress to end-stage renal failure

20/24 diseases for PTPRO (see all 24): About MalaCards

diffuse large b-cell lymphoma end stage renal failure focal segmental glomerulosclerosis b-cell lymphomas

crescentic glomerulonephritis glomerulosclerosis esophageal squamous cell carcinoma wilms tumor

squamous cell carcinoma nephrotic syndrome chronic lymphocytic leukemia lymphocytic leukemia

ulcerative colitis glomerulonephritis hyperlipidemia nephropathy

nephritis esophagitis leukemia lung cancer

1 disease from the University of Copenhagen DISEASES database for PTPRO:

Glomerulonephritis

9 Novoseek disease relationships for PTPRO gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glomerulosclerosis, focal segmental	63.8	1	16564554 (1)
glomerulosclerosis	53.3	1	9639039 (1)
wilms tumor	52.5	5	14569107 (2), 11158216 (1), 14531804 (1)
nephrotic syndrome	46.2	2	9639039 (2)
proteinuria	41.9	2	16564554 (1), 17593862 (1)
lung tumor	38	2	17545520 (1), 15356345 (1)
renal disease	7.29	4	17593862 (2), 9639039 (1)
tumors	0	6	15803146 (2), 15356345 (2), 17545520 (1), 19095770 (1)
cancer	0	1	15803146 (1)

Human Genome Epidemiology (HuGE) Navigator: PTPRO (7 documents)

Export disorders for PTPRO gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PTPRO gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with PTPRO)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13. (PubMed id 7665166)^{1, 2, 3, 9} Wiggins R.C....Thomas P.E. (1995)
Disruption of PTPRO causes childhood-onset nephrotic syndrome. (PubMed id 21722858)^{1, 2, 3} Ozaltin F....Bakkaloglu A. (2011)
PTPROt: an alternatively spliced and developmentally regulated B- lymphoid phosphatase that promotes G0/G1 arrest. (PubMed id 10498613)^{1, 2, 9} Aguiar R.C....Shipp M.A. (1999)
Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)^{1, 2} Barr A.J.... Knapp S. (2009)
Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents. (PubMed id 7753550)^{1, 2} Seimiya H.... Tsuruo T. (1995)
Estrogen-mediated suppression of the gene encoding pr otein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity. (PubMed id 19095770)^{1, 9} Ramaswamy B....Jacob S.T. (2009)
Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy. (PubMed id 17593862)^{1, 9} Tian J....Chen J.H. (2007)
Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia. (PubMed id 17545520)^{1, 9} Motiwala T....Jacob S.T. (2007)
Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. (PubMed id 15356345)^{1, 9} Motiwala T....Jacob S.T. (2004)
GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis. (PubMed id 19233845)^{1, 9} Gobert R.P....van Huijsduijnen R.H. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5800	HGNC: 9678	AceView: PTPRO	Ensembl:ENSG00000151490	euGenes: HUgn5800
ECgene: PTPRO	H-InvDB: PTPRO

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PTPRO	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PTPRO gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PTPRO gene:
Search GeneIP for patents involving PTPRO

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section

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protein tyrosine phosphatase, receptor type, O

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