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PTPRN2 Gene

protein-coding   GIFtS: 68
GCID: GC07M157331

Protein Tyrosine Phosphatase, Receptor Type, N Polypeptide...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Receptor Type, N Polypeptide 21 2     PTPRP2
IAR2 3 5     IAR/Receptor-Like Protein-Tyrosine Phosphatase2
ICAAR2 3 5     phogrin2
Islet Cell Autoantigen-Related Protein2 3     Protein Tyrosine Phosphatase Receptor Pi2
R-PTP-N22 3     Receptor-Type Tyrosine-Protein Phosphatase N22
EC 3.1.3.483 8     Tyrosine Phosphatase IA-2 Beta2
IAR PTPRP1     KIAA03873
IA-2beta2     Phogrin3

External Ids:    HGNC: 96771   Entrez Gene: 57992   Ensembl: ENSG000001550937   OMIM: 6016985   UniProtKB: Q929323   

Export aliases for PTPRN2 gene to outside databases

Previous GC identifers: GC07M155562 GC07M156175 GC07M156634 GC07M156748 GC07M156831 GC07M157024 GC07M151062


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPRN2 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane
region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic
domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major
autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants
of this gene, which encode distinct proteins, have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTPRN2 Gene:
PTPRN2 (protein tyrosine phosphatase, receptor type, N polypeptide 2) is a protein-coding gene. Diseases associated with PTPRN2 include melkersson-rosenthal syndrome, and multiple cranial nerve palsy. GO annotations related to this gene include transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPN1.

UniProtKB/Swiss-Prot: PTPR2_HUMAN, Q92932
Function: Implicated in development of nervous system and pancreatic endocrine cells

Gene Wiki entry for PTPRN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPRN2 gene promoter:
         AP-1   ATF-2   AP-2alpha isoform 2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PTPRN2 promoter sequence
   Search Chromatin IP Primers for PTPRN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPRN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36   Ensembl cytogenetic band:  7q36.3   HGNC cytogenetic band: 7q36

PTPRN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRN2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M157331:  view genomic region     (about GC identifiers)

Start:
157,331,750 bp from pter      End:
158,380,482 bp from pter
Size:
1,048,733 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 156,563,177-157,584,848     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PTPR2_HUMAN, Q92932 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein phosphatase N2 precursor  
Size: 1015 amino acids; 111271 Da
Miscellaneous: Autoantigen in insulin-dependent diabetes mellitus (IDDM)
Sequence caution: Sequence=BAA20841.2; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for PTPRN2:
2QEP (3D)        4HTI (3D)        4HTJ (3D)    
Secondary accessions: E9PC57 Q8N4I5 Q92662 Q9Y4F8 Q9Y4I6
Alternative splicing: 4 isoforms:  Q92932-1   Q92932-2   Q92932-3   Q92932-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPRN2: NX_Q92932

Explore proteomics data for PTPRN2 at MOPED

Post-translational modifications: 

  • Appears to undergo multiple proteolytic cleavage at consecutive basic residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for PTPRN2 (Q92932)
     PIIVHCS  YIATQGP  ETRTVTQFHFLSW 


    See PTPRN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_002838.2  NP_570857.2  NP_570858.2  

    ENSEMBL proteins: 
     ENSP00000374064   ENSP00000387114   ENSP00000374067   ENSP00000374069   ENSP00000385464  

    PTPRN2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for PTPRN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTPR: Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like

    IUPHAR Guide to PHARMACOLOGY protein family classification: Type N2
    Receptor tyrosine phosphatases (RTP)

    4 InterPro protein domains:
     IPR021613 Receptor_IA-2
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry Q92932

    ProtoNet protein and cluster: Q92932

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTPR2_HUMAN, Q92932
    Domain: The cytoplasmic domain appears to contain the autoantigenic epitopes
    Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    PTPRN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTPR2_HUMAN, Q92932
    Function: Implicated in development of nervous system and pancreatic endocrine cells
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Biophysicochemical properties: pH dependence: Optimum pH is 4.5;

         Genatlas biochemistry entry for PTPRN2:
    phogrin,protein tyrosine phosphatase,receptor-type,N,polypeptide 2,homolog of mouse IA2B/ICAR gene,encoding an
    autoantigen in insulin-dependent diabetes

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0005001transmembrane receptor protein tyrosine phosphatase activity TAS8798755
    GO:0005515protein binding ----
    GO:0016791phosphatase activity ----
         
    PTPRN2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PTPRN2:
     Increased apoptosis  Increased cell death in breast 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ptprn2):
     homeostasis/metabolism 

    PTPRN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptprn2tm1Aln for PTPRN2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTPRN2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPRN2

    miRNA
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    miRTarBase miRNAs that target PTPRN2:
    hsa-mir-335-5p (MIRT002430)

    Block miRNA regulation of human, mouse, rat PTPRN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPRN2 (see all 13):
    hsa-miR-577 hsa-miR-425 hsa-miR-1271 hsa-miR-516b* hsa-miR-342-3p hsa-miR-337-3p hsa-miR-3692 hsa-miR-182
    SwitchGear 3'UTR luciferase reporter plasmidPTPRN2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PTPRN2

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    GenScript: all cDNA clones in your preferred vector (see all 3): PTPRN2 (NM_130842)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTPR2_HUMAN, Q92932: Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    golgi apparatus1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005788endoplasmic reticulum lumen IEA--
    GO:0005887integral component of plasma membrane TAS8798755
    GO:0030141secretory granule IEA--
    GO:0030658transport vesicle membrane IEA--

    PTPRN2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPRN2 About    
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Type I diabetes mellitus0.69
    2PAK Pathway
    Epithelial Adherens Junctions0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPRN2
        Epithelial Adherens Junctions


    1 Kegg Pathway  (Kegg details for PTPRN2):
        Type I diabetes mellitus


    PTPRN2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PTPRN2: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPRN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for PTPRN2 (Q929322, 3 ENSP000003740694) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CKAP5Q140083, ENSP000003465664I2D: score=3 STRING: ENSP00000346566
    SPTBN4Q9H2543, ENSP000002633734I2D: score=2 STRING: ENSP00000263373
    UBQLN4Q9NRR53, ENSP000003572924I2D: score=2 STRING: ENSP00000357292
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    NR3C1P041503I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS8798755
    GO:0016311dephosphorylation ----
    GO:0034260negative regulation of GTPase activity IEA--
    GO:0035335peptidyl-tyrosine dephosphorylation TAS8798755

    PTPRN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPRN2 (PTPR2)

    2 HMDB Compounds for PTPRN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    6 Novoseek inferred chemical compound relationships for PTPRN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 58.7 32 12697028 (3), 8878534 (2), 8772720 (2), 8798755 (1) (see all 23)
    glucose 19.1 3 10417318 (1), 15220191 (1), 11353772 (1)
    glutamate 18.4 5 16498058 (2), 10886245 (1), 10668918 (1), 10634407 (1)
    forskolin 15 1 10417318 (1)
    alanine 10.9 1 12697028 (1)
    aspartate 4.89 1 11353772 (1)



    PTPRN2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PTPRN2 gene (3 alternative transcripts): 
    NM_002847.3  NM_130842.2  NM_130843.2  

    Unigene Cluster for PTPRN2:

    Protein tyrosine phosphatase, receptor type, N polypeptide 2
    Hs.490789  [show with all ESTs]
    Unigene Representative Sequence: AB002385
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389413(uc003wno.3 uc003wnq.3) ENST00000409483(uc003wnr.3)
    ENST00000389416(uc003wnp.3) ENST00000389418(uc011kwa.2) ENST00000404321

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    hsa-miR-577 hsa-miR-425 hsa-miR-1271 hsa-miR-516b* hsa-miR-342-3p hsa-miR-337-3p hsa-miR-3692 hsa-miR-182
    SwitchGear 3'UTR luciferase reporter plasmidPTPRN2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat PTPRN2

    Additional mRNA sequence: 

    AB002385.2 AF007555.1 AL157451.1 BC034040.1 BC071570.1 U65065.1 U66702.1 U81561.1 

    21 DOTS entries:

    DT.447363  DT.97791369  DT.121074766  DT.100779471  DT.100779473  DT.40132538  DT.92442879  DT.100779470 
    DT.100779474  DT.121074739  DT.100779472  DT.102843572  DT.100779467  DT.100779468  DT.102843573  DT.91851038 
    DT.92442895  DT.92442897  DT.95203839  DT.95257714  DT.97776679 

    2 AceView cDNA sequences:

    BI197929 AW815809 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTPRN2 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
    SP1:                                      -           -     -                                         -           -           -           -                     
    SP2:                                                  -     -                                         -           -           -           -                     
    SP3:                                      -           -     -                                         -           -     -     -           -                     
    SP4:                                      -           -     -     -                                   -           -           -           -                     
    SP5:                                      -     -     -     -                                         -           -           -           -                     

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b · 31c · 31d · 31e
    SP1:              -                                   -     -                                             
    SP2:              -                                   -     -                                             
    SP3:              -                                   -     -                                             
    SP4:              -                                   -     -                                             
    SP5:              -                                   -     -                                             


    ECgene alternative splicing isoforms for PTPRN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPRN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATTGTAAT
    PTPRN2 Expression
    About this image


    PTPRN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
     
     Neural Tube (Nervous System)
             Floor plate-like cells
    PTPRN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPRN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.490789

    UniProtKB/Swiss-Prot: PTPR2_HUMAN, Q92932
    Tissue specificity: Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal
    chord

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              Protein Phosphatases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTPRN2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptprn21 , 5 protein tyrosine phosphatase, receptor type, N polypeptide more1, 5 75.8(n)1
    70.47(a)1
      12 (62.65 cM)5
    192761  NM_011215.21  NP_035345.21 
     1164857205 
    chicken
    (Gallus gallus)
    Aves PTPRN21 protein tyrosine phosphatase, receptor type, N polypeptide more 62.58(n)
    58.26(a)
      420449  XM_418552.4  XP_418552.4 
    lizard
    (Anolis carolinensis)
    Reptilia PTPRN26
    protein tyrosine phosphatase, receptor type, N pol...
    54(a)
    1 ↔ 1
    6(6740988-7290662)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ptprn21 protein tyrosine phosphatase, receptor type, N polypeptide more 61.19(n)
    57.86(a)
      100495746  XM_002935174.2  XP_002935220.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ptprn21 protein tyrosine phosphatase, receptor type, N polypeptide more 45.61(n)
    35.79(a)
      325033  NM_001128667.1  NP_001122139.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ia23 protein amino acid dephosphorylation
    protein tyrosine more
    63(a)   21E2   --
    worm
    (Caenorhabditis elegans)
    Secernentea ida-13 protein tyrosine phosphatase 32(a)   III(5827369-5837359)   --


    ENSEMBL Gene Tree for PTPRN2 (if available)
    TreeFam Gene Tree for PTPRN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPRN2 gene
    PTPN12  PTPN222  PTPN112  PTPN92  PTPN62  PTPRN2  PTPN142  PTPN212  
    PTPN20B2  PTPN22  PTPN122  PTPN182  PTPN20A2  
    13 SIMAP similar genes for PTPRN2 using alignment to 3 protein entries:     PTPR2_HUMAN (see all proteins):
    DKFZp761A0712    PTPRN    BPTP-2    BPTP-3    DKFZp781C1038    PTPRS
    PTPN3    PTPRR    PTPN5    PTPN4    PTPN7    PTPRM
    PTN2

    PTPRN2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PTPRN2
    PGOHUM00000241499


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPRN2 (see all 31765)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356484
    A colorectal cancer sample4--see VAR_0356482 E K mis40--------
    rs1939208061,2
    Cuntested1157414059(-) CGTGCC/TGACCT 6 P L mis10--------
    rs126684761,2
    C,A,Huntested1157667510(+) tcatgA/C/Gacaca 3 -- int14NS EA 420
    rs1498534231,2
    C,Funtested1157903565(+) CGGGCG/AACGTC 5 /V int1 syn11Minor allele frequency- A:0.01NA 3312
    rs2212511,2
    C,F,A--157331252(+) AGTTTA/GAATAT 3 -- ds500116Minor allele frequency- G:0.22NA WA CSA EA 519
    rs1879957441,2
    --157331292(+) GGTGTA/GATTGT 3 -- ds50010--------
    rs1436183761,2
    --157331357(+) AGATGA/GAATCG 3 -- ds50010--------
    rs1440483341,2
    --157331468(+) GTGCCC/TTATCC 3 -- ds50010--------
    rs1482604711,2
    --157331500(+) GGGCAC/TGGAGG 3 -- ds50010--------
    rs1149043071,2
    F--157331508(+) AGGGCG/ATGTGT 3 -- ds50011Minor allele frequency- A:0.07WA 118

    HapMap Linkage Disequilibrium report for PTPRN2 (157331750 - 157581750 bp, first 250kb of PTPRN2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTPRN2 (see all 591):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1071922CNV Deletion17803354
    esv2735909CNV Deletion23290073
    esv2735759CNV Deletion23290073
    esv2663923CNV Deletion23128226
    esv2735899CNV Deletion23290073
    esv2735880CNV Deletion23290073
    esv2735701CNV Deletion23290073
    esv2735825CNV Deletion23290073
    esv2735935CNV Deletion23290073
    esv2735951CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601698    OMIM disorders: --

    Selected diseases for PTPRN2 (see all 24):    
    About MalaCards
    melkersson-rosenthal syndrome    multiple cranial nerve palsy    aortic valve insufficiency    brain stem glioma
    cranial nerve palsy    spondylolysis    diabetes mellitus    insulinoma
    glucose intolerance    myopia    bipolar disorder    kidney disease
    type 1 diabetes    asthma    breast and colorectal cancer    ataxia
    hypertension    schizophrenia    obesity    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for PTPRN2:
    Spondylolysis     Asthma

    PTPRN2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PTPRN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulinoma 69.5 10 8772720 (2), 8826969 (1), 9639579 (1), 9588444 (1) (see all 7)
    autoimmunity 48.2 4 9389426 (1), 9588444 (1), 19120304 (1)
    autoimmune response 46.6 1 8772720 (1)
    diabetes mellitus insulin-dependent 41.2 3 19550073 (1), 9389426 (1), 11206415 (1)

    Genetic Association Database (GAD): PTPRN2
    Human Genome Epidemiology (HuGE) Navigator: PTPRN2 (10 documents)

    Export disorders for PTPRN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPRN2 gene, integrated from 10 sources (see all 87):
    (articles sorted by number of sources associating them with PTPRN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins. (PubMed id 8954911)1, 2, 3, 9 Smith P.D.... Crompton M.R. (Biochem. Biophys. Res. Commun. 1996)
    2. Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes. (PubMed id 8878534)1, 2, 9 Kawasaki E.... Eisenbarth G.S. (Biochem. Biophys. Res. Commun. 1996)
    3. Cloning and characterization of islet cell antigen-related protein- tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes. (PubMed id 8798755)1, 2, 9 Cui L.... Pallen C.J. (J. Biol. Chem. 1996)
    4. Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes. (PubMed id 21057379)1, 4 Curtis D....Gurling H.M. (Psychiatr. Genet. 2011)
    5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    6. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    7. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PubMed id 19724895)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5799 HGNC: 9677 AceView: PTPRN2.4 Ensembl:ENSG00000155093 euGenes: HUgn5799
    ECgene: PTPRN2 Kegg: 5799 H-InvDB: PTPRN2

    (According to HUGE)
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    HUGE: KIAA0387

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PTPRN2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPRN2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPRN2 gene:
    Search GeneIP for patents involving PTPRN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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