Aliases for PTPRN Gene
External Ids for PTPRN Gene
Previous GeneCards Identifiers for PTPRN Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
GeneCards Summary for PTPRN Gene
PTPRN (Protein Tyrosine Phosphatase, Receptor Type, N) is a Protein Coding gene. Diseases associated with PTPRN include microinvasive cervical squamous cell carcinoma and maternally inherited diabetes and deafness. Among its related pathways are PAK Pathway and Allograft rejection. GO annotations related to this gene include phosphatase activity and spectrin binding. An important paralog of this gene is PTPN6.
UniProtKB/Swiss-Prot for PTPRN Gene
Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.