Aliases for PTPRM Gene
External Ids for PTPRM Gene
Previous HGNC Symbols for PTPRM Gene
Previous GeneCards Identifiers for PTPRM Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPRM Gene
PTPRM (Protein Tyrosine Phosphatase, Receptor Type M) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules (CAMs) and Cell adhesion_Cadherin-mediated cell adhesion. GO annotations related to this gene include identical protein binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRT.
UniProtKB/Swiss-Prot for PTPRM Gene
Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.