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Aliases for PTPRM Gene

Aliases for PTPRM Gene

  • Protein Tyrosine Phosphatase, Receptor Type M 2 3 5
  • EC 4 61
  • R-PTP-MU 3 4
  • PTPRL1 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, Mu Polypeptide 3
  • Receptor-Type Tyrosine-Protein Phosphatase Mu 3
  • Protein Tyrosine Phosphatase Mu 3
  • Protein-Tyrosine Phosphatase Mu 4
  • HR-PTPu 3
  • RPTPM 3
  • RPTPU 3

External Ids for PTPRM Gene

Previous HGNC Symbols for PTPRM Gene

  • PTPRL1

Previous GeneCards Identifiers for PTPRM Gene

  • GC18M008568
  • GC18P007632

Summaries for PTPRM Gene

Entrez Gene Summary for PTPRM Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRM Gene

PTPRM (Protein Tyrosine Phosphatase, Receptor Type M) is a Protein Coding gene. Among its related pathways are Adhesion and Adherens junction. GO annotations related to this gene include identical protein binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRT.

UniProtKB/Swiss-Prot for PTPRM Gene

  • Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.

Gene Wiki entry for PTPRM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRM Gene

Genomics for PTPRM Gene

Regulatory Elements for PTPRM Gene

Enhancers for PTPRM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F007616 1.7 Ensembl ENCODE 11 +51.3 51277 3.3 ZNF610 RAD21 PTPRM GC18M007548
GH18F007626 1.2 Ensembl ENCODE 10.9 +60.2 60247 1.7 ELF3 DMAP1 RAD21 DNMT3B ZNF48 RARA YY1 FOS CREM CEBPB PTPRM GC18M007548 ENSG00000266767
GH18F007751 1.3 FANTOM5 Ensembl ENCODE 9.7 +184.3 184325 0.5 SOX13 SAP130 CEBPG RARA TEAD3 SCRT2 NR2F6 GATAD2A NFIA TEAD1 PTPRM ENSG00000266767 GC18M007548
GH18F007753 1.2 Ensembl ENCODE 10.4 +188.1 188137 2.1 ELF3 TBP ATF1 ARID4B ZNF48 THRB RAD21 YY1 RARA GATA4 PTPRM ENSG00000266767 GC18P007756
GH18F007459 1.1 FANTOM5 Ensembl 10.6 -106.4 -106389 1.2 SOX13 ELF3 TFAP4 SAP130 ZNF48 RARA SCRT2 NR2F6 GATAD2A SCRT1 PTPRM LOC105371976 LOC105371975
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTPRM on UCSC Golden Path with GeneCards custom track

Promoters for PTPRM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001512940 1218 3600 ATF1 CREB3L1 DEAF1 ARID4B SIN3A RAD21 ZEB1 ZNF335 GLIS2 CREM

Genomic Location for PTPRM Gene

7,566,782 bp from pter
8,406,861 bp from pter
840,080 bases
Plus strand

Genomic View for PTPRM Gene

Genes around PTPRM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRM Gene

Proteins for PTPRM Gene

  • Protein details for PTPRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-type tyrosine-protein phosphatase mu
    Protein Accession:
    Secondary Accessions:
    • A7MBN1
    • D3DUH8
    • J3QL11

    Protein attributes for PTPRM Gene

    1452 amino acids
    Molecular mass:
    163682 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPRM Gene

    Alternative splice isoforms for PTPRM Gene


neXtProt entry for PTPRM Gene

Selected DME Specific Peptides for PTPRM Gene


Post-translational modifications for PTPRM Gene

  • Glycosylation at Asn 72, Asn 92, Asn 131, Asn 249, Asn 406, Asn 414, Asn 454, Asn 534, Asn 544, Asn 598, Asn 651, and Asn 681
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTPRM (PTPRM)
  • Cloud-Clone Corp. Antibodies for PTPRM

Domains & Families for PTPRM Gene

Suggested Antigen Peptide Sequences for PTPRM Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
  • Contains 4 fibronectin type-III domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 MAM domain.
  • Contains 2 tyrosine-protein phosphatase domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
genes like me logo Genes that share domains with PTPRM: view

Function for PTPRM Gene

Molecular function for PTPRM Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type,mu polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.

Enzyme Numbers (IUBMB) for PTPRM Gene

Gene Ontology (GO) - Molecular Function for PTPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,IDA 8393854
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity IDA 10809770
GO:0005515 protein binding IPI 9531566
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PTPRM: view
genes like me logo Genes that share phenotypes with PTPRM: view

Animal Models for PTPRM Gene

MGI Knock Outs for PTPRM:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPRM

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRM Gene

Localization for PTPRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRM Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRM gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PTPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16380380
GO:0005887 integral component of plasma membrane NAS 1655529
GO:0005911 cell-cell junction IDA 15491993
GO:0005913 cell-cell adherens junction IDA 17965016
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PTPRM: view

Pathways & Interactions for PTPRM Gene

genes like me logo Genes that share pathways with PTPRM: view

Pathways by source for PTPRM Gene

1 Cell Signaling Technology pathway for PTPRM Gene
1 BioSystems pathway for PTPRM Gene
2 KEGG pathways for PTPRM Gene
1 GeneGo (Thomson Reuters) pathway for PTPRM Gene
1 Qiagen pathway for PTPRM Gene

Gene Ontology (GO) - Biological Process for PTPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IMP 18566238
GO:0006470 protein dephosphorylation IEA,IDA 8393854
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA 8393854
GO:0007165 signal transduction IDA 15080886
genes like me logo Genes that share ontologies with PTPRM: view

No data available for SIGNOR curated interactions for PTPRM Gene

Drugs & Compounds for PTPRM Gene

(4) Drugs for PTPRM Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1518
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PTPRM Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with PTPRM: view

Transcripts for PTPRM Gene

Unigene Clusters for PTPRM Gene

Protein tyrosine phosphatase, receptor type, M:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRM Gene

No ASD Table

Relevant External Links for PTPRM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPRM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPRM Gene

Protein differential expression in normal tissues from HIPED for PTPRM Gene

This gene is overexpressed in Serum (43.2) and Colon muscle (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTPRM Gene

NURSA nuclear receptor signaling pathways regulating expression of PTPRM Gene:


SOURCE GeneReport for Unigene cluster for PTPRM Gene:

genes like me logo Genes that share expression patterns with PTPRM: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PTPRM Gene

Orthologs for PTPRM Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRM Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTPRM 34 35
  • 99.57 (n)
(Monodelphis domestica)
Mammalia PTPRM 35
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
-- 35
  • 90 (a)
(Canis familiaris)
Mammalia PTPRM 34 35
  • 91.45 (n)
(Bos Taurus)
Mammalia PTPRM 34 35
  • 88.58 (n)
(Mus musculus)
Mammalia Ptprm 34 16 35
  • 88.5 (n)
(Rattus norvegicus)
Mammalia Ptprm 34
  • 87.66 (n)
(Gallus gallus)
Aves PTPRM 35
  • 91 (a)
LOC421049 34
  • 81.82 (n)
(Anolis carolinensis)
Reptilia PTPRM 35
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprm 34
  • 77.39 (n)
(Danio rerio)
Actinopterygii PTPRM (2 of 2) 35
  • 95 (a)
PTPRM (1 of 2) 35
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ptp69D 36
  • 34 (a)
CG7180 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea F47B3.7 36
  • 36 (a)
Y48G9A.9 36
  • 35 (a)
ZK484.7 36
  • 32 (a)
C55B7.3 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1390 35
  • 39 (a)
Species where no ortholog for PTPRM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRM Gene

Gene Tree for PTPRM (if available)
Gene Tree for PTPRM (if available)

Paralogs for PTPRM Gene

Variants for PTPRM Gene

Sequence variations from dbSNP and Humsavar for PTPRM Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1002715 -- 7,940,119(-) TAAAC(A/T)GTGAA intron-variant
rs1003420 -- 8,215,745(-) aatag(C/G)gagac intron-variant
rs1003421 -- 8,215,652(-) gatga(A/G)aggat intron-variant
rs1003422 -- 8,215,551(-) aaaaa(A/G)aaaaa intron-variant
rs10048238 -- 8,158,170(+) GTTCT(A/G)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRM Gene

Variant ID Type Subtype PubMed ID
nsv458021 CNV loss 19166990
nsv458020 CNV loss 19166990
nsv458017 CNV loss 19166990
nsv2198 CNV insertion 18451855
nsv2197 CNV insertion 18451855
nsv130934 CNV deletion 16902084
nsv1160505 CNV duplication 26073780
nsv1152561 CNV insertion 26484159
nsv1148992 CNV duplication 26484159
nsv1141314 CNV duplication 24896259
nsv1139682 CNV duplication 24896259
nsv1138602 CNV deletion 24896259
nsv1131350 CNV deletion 24896259
nsv1117191 CNV tandem duplication 24896259
nsv1064849 CNV gain 25217958
nsv1063350 CNV gain 25217958
nsv1062454 CNV loss 25217958
nsv1058445 CNV loss 25217958
nsv1055995 CNV loss 25217958
esv6046 CNV gain 19470904
esv3893069 CNV loss 25118596
esv3641713 CNV loss 21293372
esv3641705 CNV loss 21293372
esv3641704 CNV loss 21293372
esv3641703 CNV loss 21293372
esv3641701 CNV loss 21293372
esv3641700 CNV loss 21293372
esv3582963 CNV loss 25503493
esv3582958 CNV loss 25503493
esv3555016 CNV deletion 23714750
esv3555012 CNV deletion 23714750
esv3427559 CNV insertion 20981092
esv3398437 CNV insertion 20981092
esv3389515 CNV insertion 20981092
esv3307134 CNV mobile element insertion 20981092
esv2762810 CNV gain+loss 21179565
esv2761987 CNV loss 21179565
esv275400 CNV gain+loss 21479260
esv2716755 CNV deletion 23290073
esv2716754 CNV deletion 23290073
esv2716753 CNV deletion 23290073
esv2716752 CNV deletion 23290073
esv2716750 CNV deletion 23290073
esv2716749 CNV deletion 23290073
esv2656311 CNV loss 23635498
esv2656232 CNV gain 23635498
esv2647835 CNV deletion 19546169
esv2586739 CNV loss 19546169
esv2451132 CNV deletion 19546169
esv2419492 CNV deletion 18987734
esv23000 CNV loss 19812545
esv1023039 CNV insertion 17803354
dgv971e212 CNV loss 25503493
dgv598e214 CNV gain 21293372
dgv597e214 CNV loss 21293372
dgv5842n54 CNV loss 21841781
dgv5841n54 CNV loss 21841781
dgv5840n54 CNV gain 21841781
dgv5839n54 CNV gain+loss 21841781
dgv5838n54 CNV gain 21841781
dgv3319n100 CNV loss 25217958
dgv196e215 CNV deletion 23714750
nsv576427 CNV loss 21841781
nsv576426 CNV gain 21841781
nsv576425 CNV loss 21841781
nsv576424 CNV loss 21841781
nsv576423 CNV loss 21841781
nsv576420 CNV loss 21841781
nsv576419 CNV loss 21841781
nsv576417 CNV gain 21841781
nsv576406 CNV loss 21841781
nsv576402 CNV loss 21841781
nsv576401 CNV gain 21841781
nsv576400 CNV loss 21841781
nsv576399 CNV gain 21841781
nsv526300 CNV loss 19592680
nsv525328 CNV loss 19592680
nsv521059 CNV loss 19592680
nsv478850 CNV novel sequence insertion 20440878
nsv475892 CNV novel sequence insertion 20440878
nsv475820 CNV novel sequence insertion 20440878
nsv472767 CNV novel sequence insertion 20440878
nsv470407 CNV loss 18288195
nsv470406 CNV loss 18288195
nsv817782 CNV loss 17921354
nsv576428 CNV loss 21841781

Variation tolerance for PTPRM Gene

Residual Variation Intolerance Score: 1.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRM Gene

Disorders for PTPRM Gene

Relevant External Links for PTPRM

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PTPRM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPRM Gene

Publications for PTPRM Gene

  1. The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu. (PMID: 9346878) Hoffmann K.M. … Barford D. (J. Biol. Chem. 1997) 3 4 22 64
  2. Fine mapping of the human receptor-like protein tyrosine phosphatase gene (PTPRM) to 18p11.2 by fluorescence in situ hybridization. (PMID: 8404049) Suijkerbuijk R.F. … Geurts van Kessel A. (Cytogenet. Cell Genet. 1993) 2 3 22 64
  3. Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase. (PMID: 1655529) Gebbink M.F.B.G. … Moolenaar W.H. (FEBS Lett. 1991) 2 3 4 64
  4. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PMID: 21546767) Murea M. … Freedman B.I. (Am. J. Nephrol. 2011) 3 46 64
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 46 64

Products for PTPRM Gene

Sources for PTPRM Gene

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