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Aliases for PTPRM Gene

Aliases for PTPRM Gene

  • Protein Tyrosine Phosphatase, Receptor Type M 2 3 5
  • Protein-Tyrosine Phosphatase Mu 3 4
  • EC 3.1.3.48 4 61
  • R-PTP-MU 3 4
  • PTPRL1 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, Mu Polypeptide 3
  • Receptor-Type Tyrosine-Protein Phosphatase Mu 3
  • Protein Tyrosine Phosphatase Mu 3
  • HR-PTPu 3
  • RPTPM 3
  • RPTPU 3

External Ids for PTPRM Gene

Previous HGNC Symbols for PTPRM Gene

  • PTPRL1

Previous GeneCards Identifiers for PTPRM Gene

  • GC18M008568
  • GC18P007632

Summaries for PTPRM Gene

Entrez Gene Summary for PTPRM Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRM Gene

PTPRM (Protein Tyrosine Phosphatase, Receptor Type M) is a Protein Coding gene. Among its related pathways are Nectin adhesion pathway and Adhesion. GO annotations related to this gene include identical protein binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRT.

UniProtKB/Swiss-Prot for PTPRM Gene

  • Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.

Gene Wiki entry for PTPRM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRM Gene

Genomics for PTPRM Gene

Regulatory Elements for PTPRM Gene

Enhancers for PTPRM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PTPRM on UCSC Golden Path with GeneCards custom track

Promoters for PTPRM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PTPRM Gene

Chromosome:
18
Start:
7,566,782 bp from pter
End:
8,406,861 bp from pter
Size:
840,080 bases
Orientation:
Plus strand

Genomic View for PTPRM Gene

Genes around PTPRM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRM Gene

Proteins for PTPRM Gene

  • Protein details for PTPRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28827-PTPRM_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase mu
    Protein Accession:
    P28827
    Secondary Accessions:
    • A7MBN1
    • D3DUH8
    • J3QL11

    Protein attributes for PTPRM Gene

    Size:
    1452 amino acids
    Molecular mass:
    163682 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPRM Gene

    Alternative splice isoforms for PTPRM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRM Gene

Post-translational modifications for PTPRM Gene

  • Glycosylation at Asn 72, Asn 92, Asn 131, Asn 249, Asn 406, Asn 414, Asn 454, Asn 534, Asn 544, Asn 598, Asn 651, and Asn 681
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTPRM (PTPRM)
  • Cloud-Clone Corp. Antibodies for PTPRM

Domains & Families for PTPRM Gene

Suggested Antigen Peptide Sequences for PTPRM Gene

Graphical View of Domain Structure for InterPro Entry

P28827

UniProtKB/Swiss-Prot:

PTPRM_HUMAN :
  • Contains 4 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Domain:
  • Contains 4 fibronectin type-III domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 MAM domain.
  • Contains 2 tyrosine-protein phosphatase domains.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
genes like me logo Genes that share domains with PTPRM: view

Function for PTPRM Gene

Molecular function for PTPRM Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type,mu polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.

Enzyme Numbers (IUBMB) for PTPRM Gene

Gene Ontology (GO) - Molecular Function for PTPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IDA 8393854
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity IDA 10809770
GO:0005515 protein binding IPI 9531566
GO:0042802 identical protein binding IPI 10809770
GO:0045296 cadherin binding IDA 9531566
genes like me logo Genes that share ontologies with PTPRM: view
genes like me logo Genes that share phenotypes with PTPRM: view

Animal Models for PTPRM Gene

MGI Knock Outs for PTPRM:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPRM

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRM Gene

Localization for PTPRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRM Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRM Gene COMPARTMENTS Subcellular localization image for PTPRM gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16380380
GO:0005887 integral component of plasma membrane NAS 1655529
GO:0005911 cell-cell junction IDA 15491993
GO:0005913 cell-cell adherens junction IDA 17965016
GO:0030027 lamellipodium IDA 15706045
genes like me logo Genes that share ontologies with PTPRM: view

Pathways & Interactions for PTPRM Gene

genes like me logo Genes that share pathways with PTPRM: view

Pathways by source for PTPRM Gene

1 Cell Signaling Technology pathway for PTPRM Gene
1 BioSystems pathway for PTPRM Gene
2 KEGG pathways for PTPRM Gene
1 GeneGo (Thomson Reuters) pathway for PTPRM Gene
1 Qiagen pathway for PTPRM Gene

Gene Ontology (GO) - Biological Process for PTPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IMP 18566238
GO:0006470 protein dephosphorylation IDA 8393854
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA 8393854
GO:0007165 signal transduction IDA 15080886
GO:0010596 negative regulation of endothelial cell migration IMP 18566238
genes like me logo Genes that share ontologies with PTPRM: view

No data available for SIGNOR curated interactions for PTPRM Gene

Drugs & Compounds for PTPRM Gene

(4) Drugs for PTPRM Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1496
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PTPRM Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PTPRM: view

Transcripts for PTPRM Gene

Unigene Clusters for PTPRM Gene

Protein tyrosine phosphatase, receptor type, M:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRM Gene

No ASD Table

Relevant External Links for PTPRM Gene

GeneLoc Exon Structure for
PTPRM
ECgene alternative splicing isoforms for
PTPRM

Expression for PTPRM Gene

mRNA expression in normal human tissues for PTPRM Gene

Protein differential expression in normal tissues from HIPED for PTPRM Gene

This gene is overexpressed in Serum (43.2) and Colon muscle (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTPRM Gene



NURSA nuclear receptor signaling pathways regulating expression of PTPRM Gene:

PTPRM

SOURCE GeneReport for Unigene cluster for PTPRM Gene:

Hs.49774
genes like me logo Genes that share expression patterns with PTPRM: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PTPRM Gene

Orthologs for PTPRM Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRM 34
  • 88.58 (n)
  • 97.47 (a)
PTPRM 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRM 34
  • 91.45 (n)
  • 98.53 (a)
PTPRM 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprm 34
  • 88.5 (n)
  • 97.52 (a)
Ptprm 16
Ptprm 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPRM 34
  • 99.57 (n)
  • 99.8 (a)
PTPRM 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprm 34
  • 87.66 (n)
  • 96.99 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPRM 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC421049 34
  • 81.82 (n)
  • 92.3 (a)
PTPRM 35
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRM 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprm 34
  • 77.39 (n)
  • 87.47 (a)
zebrafish
(Danio rerio)
Actinopterygii PTPRM (1 of 2) 35
  • 41 (a)
OneToMany
PTPRM (2 of 2) 35
  • 95 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7180 36
  • 33 (a)
Ptp69D 36
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea C55B7.3 36
  • 31 (a)
F47B3.7 36
  • 36 (a)
Y48G9A.9 36
  • 35 (a)
ZK484.7 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1390 35
  • 39 (a)
OneToMany
Species where no ortholog for PTPRM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRM Gene

ENSEMBL:
Gene Tree for PTPRM (if available)
TreeFam:
Gene Tree for PTPRM (if available)

Paralogs for PTPRM Gene

Paralogs for PTPRM Gene

genes like me logo Genes that share paralogs with PTPRM: view

Variants for PTPRM Gene

Sequence variations from dbSNP and Humsavar for PTPRM Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs35224276 - 7,774,192(-) GATTG(A/T)CTATA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs754140 -- 8,334,160(+) AGCCA(C/T)CTAGT intron-variant
rs759094 -- 8,190,282(-) TGTGT(A/G)GGGAG intron-variant
rs759095 -- 8,190,094(-) TGATT(G/T)AGCAG intron-variant
rs789451 -- 7,795,725(+) TACTA(A/G)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRM Gene

Variant ID Type Subtype PubMed ID
dgv196e215 CNV deletion 23714750
dgv3319n100 CNV loss 25217958
dgv5838n54 CNV gain 21841781
dgv5839n54 CNV gain+loss 21841781
dgv5840n54 CNV gain 21841781
dgv5841n54 CNV loss 21841781
dgv5842n54 CNV loss 21841781
dgv597e214 CNV loss 21293372
dgv598e214 CNV gain 21293372
dgv971e212 CNV loss 25503493
esv1023039 CNV insertion 17803354
esv23000 CNV loss 19812545
esv2419492 CNV deletion 18987734
esv2451132 CNV deletion 19546169
esv2586739 CNV loss 19546169
esv2647835 CNV deletion 19546169
esv2656232 CNV gain 23635498
esv2656311 CNV loss 23635498
esv2716749 CNV deletion 23290073
esv2716750 CNV deletion 23290073
esv2716752 CNV deletion 23290073
esv2716753 CNV deletion 23290073
esv2716754 CNV deletion 23290073
esv2716755 CNV deletion 23290073
esv275400 CNV gain+loss 21479260
esv2761987 CNV loss 21179565
esv2762810 CNV gain+loss 21179565
esv3307134 CNV mobile element insertion 20981092
esv3389515 CNV insertion 20981092
esv3398437 CNV insertion 20981092
esv3427559 CNV insertion 20981092
esv3555012 CNV deletion 23714750
esv3555016 CNV deletion 23714750
esv3582958 CNV loss 25503493
esv3582963 CNV loss 25503493
esv3641700 CNV loss 21293372
esv3641701 CNV loss 21293372
esv3641703 CNV loss 21293372
esv3641704 CNV loss 21293372
esv3641705 CNV loss 21293372
esv3641713 CNV loss 21293372
esv3893069 CNV loss 25118596
esv6046 CNV gain 19470904
nsv1055995 CNV loss 25217958
nsv1058445 CNV loss 25217958
nsv1062454 CNV loss 25217958
nsv1063350 CNV gain 25217958
nsv1064849 CNV gain 25217958
nsv1117191 CNV tandem duplication 24896259
nsv1131350 CNV deletion 24896259
nsv1138602 CNV deletion 24896259
nsv1139682 CNV duplication 24896259
nsv1141314 CNV duplication 24896259
nsv1148992 CNV duplication 26484159
nsv1152561 CNV insertion 26484159
nsv1160505 CNV duplication 26073780
nsv130934 CNV deletion 16902084
nsv2197 CNV insertion 18451855
nsv2198 CNV insertion 18451855
nsv458017 CNV loss 19166990
nsv458020 CNV loss 19166990
nsv458021 CNV loss 19166990
nsv470406 CNV loss 18288195
nsv470407 CNV loss 18288195
nsv472767 CNV novel sequence insertion 20440878
nsv475820 CNV novel sequence insertion 20440878
nsv475892 CNV novel sequence insertion 20440878
nsv478850 CNV novel sequence insertion 20440878
nsv521059 CNV loss 19592680
nsv525328 CNV loss 19592680
nsv526300 CNV loss 19592680
nsv576399 CNV gain 21841781
nsv576400 CNV loss 21841781
nsv576401 CNV gain 21841781
nsv576402 CNV loss 21841781
nsv576406 CNV loss 21841781
nsv576417 CNV gain 21841781
nsv576419 CNV loss 21841781
nsv576420 CNV loss 21841781
nsv576423 CNV loss 21841781
nsv576424 CNV loss 21841781
nsv576425 CNV loss 21841781
nsv576426 CNV gain 21841781
nsv576427 CNV loss 21841781
nsv576428 CNV loss 21841781
nsv817782 CNV loss 17921354

Variation tolerance for PTPRM Gene

Residual Variation Intolerance Score: 1.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPRM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRM Gene

Disorders for PTPRM Gene

Relevant External Links for PTPRM

Genetic Association Database (GAD)
PTPRM
Human Genome Epidemiology (HuGE) Navigator
PTPRM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRM

No disorders were found for PTPRM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPRM Gene

Publications for PTPRM Gene

  1. The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu. (PMID: 9346878) Hoffmann K.M. … Barford D. (J. Biol. Chem. 1997) 3 4 22 65
  2. Fine mapping of the human receptor-like protein tyrosine phosphatase gene (PTPRM) to 18p11.2 by fluorescence in situ hybridization. (PMID: 8404049) Suijkerbuijk R.F. … Geurts van Kessel A. (Cytogenet. Cell Genet. 1993) 2 3 22 65
  3. Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase. (PMID: 1655529) Gebbink M.F.B.G. … Moolenaar W.H. (FEBS Lett. 1991) 2 3 4 65
  4. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PMID: 21546767) Murea M. … Freedman B.I. (Am. J. Nephrol. 2011) 3 46 65
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 46 65

Products for PTPRM Gene

Sources for PTPRM Gene

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