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Aliases for PTPRM Gene

Aliases for PTPRM Gene

  • Protein Tyrosine Phosphatase, Receptor Type M 2 3
  • Protein Tyrosine Phosphatase, Receptor Type, M 3 5
  • Protein-Tyrosine Phosphatase Mu 3 4
  • EC 3.1.3.48 4 63
  • R-PTP-MU 3 4
  • PTPRL1 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, Mu Polypeptide 3
  • Protein Tyrosine Phosphatase Mu 3
  • HR-PTPu 3
  • RPTPM 3
  • RPTPU 3

External Ids for PTPRM Gene

Previous HGNC Symbols for PTPRM Gene

  • PTPRL1

Previous GeneCards Identifiers for PTPRM Gene

  • GC18M008568
  • GC18P007632

Summaries for PTPRM Gene

Entrez Gene Summary for PTPRM Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRM Gene

PTPRM (Protein Tyrosine Phosphatase, Receptor Type M) is a Protein Coding gene. Among its related pathways are Adherens junction and PAK Pathway. GO annotations related to this gene include identical protein binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRK.

UniProtKB/Swiss-Prot for PTPRM Gene

  • Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.

Gene Wiki entry for PTPRM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRM Gene

Genomics for PTPRM Gene

Regulatory Elements for PTPRM Gene

Promoters for PTPRM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTPRM on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPRM Gene

Chromosome:
18
Start:
7,566,782 bp from pter
End:
8,406,861 bp from pter
Size:
840,080 bases
Orientation:
Plus strand

Genomic View for PTPRM Gene

Genes around PTPRM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRM Gene

Proteins for PTPRM Gene

  • Protein details for PTPRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28827-PTPRM_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase mu
    Protein Accession:
    P28827
    Secondary Accessions:
    • A7MBN1
    • D3DUH8
    • J3QL11

    Protein attributes for PTPRM Gene

    Size:
    1452 amino acids
    Molecular mass:
    163682 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPRM Gene

    Alternative splice isoforms for PTPRM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRM Gene

Proteomics data for PTPRM Gene at MOPED

Post-translational modifications for PTPRM Gene

  • Glycosylation at Asn 72, Asn 92, Asn 131, Asn 249, Asn 406, Asn 414, Asn 454, Asn 534, Asn 544, Asn 598, Asn 651, and Asn 681
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTPRM (PTPRM)
  • Cloud-Clone Corp. Antibodies for PTPRM

Domains & Families for PTPRM Gene

Suggested Antigen Peptide Sequences for PTPRM Gene

Graphical View of Domain Structure for InterPro Entry

P28827

UniProtKB/Swiss-Prot:

PTPRM_HUMAN :
  • Contains 4 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Domain:
  • Contains 4 fibronectin type-III domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 MAM domain.
  • Contains 2 tyrosine-protein phosphatase domains.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
genes like me logo Genes that share domains with PTPRM: view

Function for PTPRM Gene

Molecular function for PTPRM Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type,mu polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.

Enzyme Numbers (IUBMB) for PTPRM Gene

genes like me logo Genes that share phenotypes with PTPRM: view

Animal Models for PTPRM Gene

MGI Knock Outs for PTPRM:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRM Gene

Localization for PTPRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRM Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRM Gene COMPARTMENTS Subcellular localization image for PTPRM gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005913 cell-cell adherens junction IDA 17965016
genes like me logo Genes that share ontologies with PTPRM: view

Pathways & Interactions for PTPRM Gene

genes like me logo Genes that share pathways with PTPRM: view

Pathways by source for PTPRM Gene

1 BioSystems pathway for PTPRM Gene
2 KEGG pathways for PTPRM Gene
1 GeneGo (Thomson Reuters) pathway for PTPRM Gene
1 Qiagen pathway for PTPRM Gene

Gene Ontology (GO) - Biological Process for PTPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IMP 18566238
GO:0006470 protein dephosphorylation IEA,IDA 8393854
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA 8393854
GO:0007165 signal transduction IDA 15080886
GO:0031175 neuron projection development IMP 17276081
genes like me logo Genes that share ontologies with PTPRM: view

No data available for SIGNOR curated interactions for PTPRM Gene

Drugs & Compounds for PTPRM Gene

(2) Drugs for PTPRM Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR, Cytotoxic agent 1444

(3) Additional Compounds for PTPRM Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTPRM: view

Transcripts for PTPRM Gene

Unigene Clusters for PTPRM Gene

Protein tyrosine phosphatase, receptor type, M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRM Gene

No ASD Table

Relevant External Links for PTPRM Gene

GeneLoc Exon Structure for
PTPRM
ECgene alternative splicing isoforms for
PTPRM

Expression for PTPRM Gene

mRNA expression in normal human tissues for PTPRM Gene

Protein differential expression in normal tissues from HIPED for PTPRM Gene

This gene is overexpressed in Serum (43.2) and Colon muscle (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRM Gene



SOURCE GeneReport for Unigene cluster for PTPRM Gene Hs.49774

genes like me logo Genes that share expression patterns with PTPRM: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PTPRM Gene

Orthologs for PTPRM Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRM 36
  • 99 (a)
OneToOne
PTPRM 35
  • 99.57 (n)
  • 99.8 (a)
cow
(Bos Taurus)
Mammalia PTPRM 35
  • 88.58 (n)
  • 97.47 (a)
PTPRM 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRM 36
  • 99 (a)
OneToOne
PTPRM 35
  • 91.45 (n)
  • 98.53 (a)
mouse
(Mus musculus)
Mammalia Ptprm 16
Ptprm 35
  • 88.5 (n)
  • 97.52 (a)
Ptprm 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPRM 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ptprm 35
  • 87.66 (n)
  • 96.99 (a)
chicken
(Gallus gallus)
Aves LOC421049 35
  • 81.82 (n)
  • 92.3 (a)
PTPRM 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRM 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprm 35
  • 77.39 (n)
  • 87.47 (a)
zebrafish
(Danio rerio)
Actinopterygii PTPRM (1 of 2) 36
  • 41 (a)
OneToMany
PTPRM (2 of 2) 36
  • 95 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7180 37
  • 33 (a)
Ptp69D 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea C55B7.3 37
  • 31 (a)
F47B3.7 37
  • 36 (a)
Y48G9A.9 37
  • 35 (a)
ZK484.7 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1390 36
  • 39 (a)
OneToMany
Species with no ortholog for PTPRM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRM Gene

ENSEMBL:
Gene Tree for PTPRM (if available)
TreeFam:
Gene Tree for PTPRM (if available)

Paralogs for PTPRM Gene

Paralogs for PTPRM Gene

genes like me logo Genes that share paralogs with PTPRM: view

Variants for PTPRM Gene

Sequence variations from dbSNP and Humsavar for PTPRM Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs35224276 - 7,774,192(-) GATTG(A/T)CTATA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs491692 -- 8,113,962(-) CCCCC(A/C)ATCAA intron-variant
rs492841 -- 8,051,886(-) AACAA(C/T)GAAAA intron-variant
rs538985 -- 8,127,012(-) AATTG(C/T)TTCCC intron-variant
rs545910 -- 8,084,337(-) GCTGT(A/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRM Gene

Variant ID Type Subtype PubMed ID
nsv526300 CNV Loss 19592680
dgv3381n71 CNV Gain 21882294
nsv909348 CNV Gain 21882294
dgv3383n71 CNV Gain 21882294
nsv909357 CNV Gain 21882294
esv2586739 CNV Loss 19546169
esv23000 CNV Loss 19812545
nsv909358 CNV Loss 21882294
nsv458017 CNV Loss 19166990
esv2716749 CNV Deletion 23290073
esv2716750 CNV Deletion 23290073
nsv470406 CNV Loss 18288195
esv271410 CNV Insertion 20981092
nsv525328 CNV Loss 19592680
esv6046 CNV Gain 19470904
esv2716752 CNV Deletion 23290073
esv2716753 CNV Deletion 23290073
nsv130934 CNV Loss 16902084
nsv2197 CNV Insertion 18451855
nsv521059 CNV Loss 19592680
esv1023039 CNV Insertion 17803354
nsv909359 CNV Loss 21882294
nsv2198 CNV Insertion 18451855
esv267735 CNV Insertion 20981092
nsv458020 CNV Loss 19166990
nsv909360 CNV Loss 21882294
nsv458021 CNV Loss 19166990
nsv470407 CNV Loss 18288195
esv2647835 CNV Deletion 19546169
esv2716754 CNV Deletion 23290073
esv275400 CNV Gain+Loss 21479260
esv2716755 CNV Deletion 23290073
nsv817782 CNV Loss 17921354
nsv909361 CNV Gain 21882294
esv2451132 CNV Deletion 19546169
esv2419492 CNV Deletion 18987734

Variation tolerance for PTPRM Gene

Residual Variation Intolerance Score: 1.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRM Gene

HapMap Linkage Disequilibrium report
PTPRM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRM Gene

Disorders for PTPRM Gene

Relevant External Links for PTPRM

Genetic Association Database (GAD)
PTPRM
Human Genome Epidemiology (HuGE) Navigator
PTPRM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRM

No disorders were found for PTPRM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPRM Gene

Publications for PTPRM Gene

  1. Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase. (PMID: 1655529) Gebbink M.F.B.G. … Moolenaar W.H. (FEBS Lett. 1991) 2 3 4 67
  2. Fine mapping of the human receptor-like protein tyrosine phosphatase gene (PTPRM) to 18p11.2 by fluorescence in situ hybridization. (PMID: 8404049) Suijkerbuijk R.F. … Geurts van Kessel A. (Cytogenet. Cell Genet. 1993) 2 3 23
  3. Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration. (PMID: 19690139) Burgoyne A.M. … Brady-Kalnay S.M. (Cancer Res. 2009) 3 23
  4. PTPmu suppresses glioma cell migration and dispersal. (PMID: 19304959) Burgoyne A.M. … Brady-Kalnay S.M. (Neuro-oncology 2009) 3 23
  5. Synergistic effects of methylnaltrexone with 5-fluorouracil and bevacizumab on inhibition of vascular endothelial growth factor-induced angiogenesis. (PMID: 18566238) Singleton P.A. … Moss J. (Mol. Cancer Ther. 2008) 3 23

Products for PTPRM Gene

Sources for PTPRM Gene

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