Aliases for PTPRK Gene
Aliases for PTPRK Gene
- Protein Tyrosine Phosphatase, Receptor Type K 2 3
- Protein Tyrosine Phosphatase, Receptor Type, K 3 5
- Protein-Tyrosine Phosphatase Kappa 3 4
- R-PTP-Kappa 3 4
- EC 3.1.3.48 4 63
- DJ480J14.2.1 (Protein Tyrosine Phosphatase, Receptor Type, K (R-PTP-KAPPA, Protein Tyrosine Phosphatase Kappa , Protein Tyrosine Phosphatase Kappa 3
- Protein-Tyrosine Phosphatase, Receptor Type, Kappa 3
- PTPK 4
External Ids for PTPRK Gene
- HGNC: 9674
- Entrez Gene: 5796
- Ensembl: ENSG00000152894
- OMIM: 602545
- UniProtKB: Q15262
Previous GeneCards Identifiers for PTPRK Gene
- GC06M128137
- GC06M128270
- GC06M128331
- GC06M125866
- GC06M128289
Summaries for PTPRK Gene
-
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPRK Gene
PTPRK (Protein Tyrosine Phosphatase, Receptor Type K) is a Protein Coding gene. Diseases associated with PTPRK include Eye Lymphoma. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and EGFR downregulation. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRS.
UniProtKB/Swiss-Prot for PTPRK Gene
-
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRK Gene
Genomics for PTPRK Gene
Regulatory Elements for PTPRK Gene
Enhancers for PTPRK Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around PTPRK on UCSC Golden Path with GeneCards custom track
Promoters for PTPRK Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around PTPRK on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PTPRK gene promoter:
Regulatory Element Products
Genomic Location for PTPRK Gene
- Chromosome:
- 6
- Start:
- 127,968,779 bp from pter
- End:
- 128,520,847 bp from pter
- Size:
- 552,069 bases
- Orientation:
- Minus strand
Genomic View for PTPRK Gene
Genes around PTPRK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q22.33 by Ensembl
- 6q22.2-q22.3 by Entrez Gene
- 6q22.2-q22.3 by HGNC
PTPRK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTPRK Gene
Proteins for PTPRK Gene
-
Protein details for PTPRK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15262-PTPRK_HUMAN
- Recommended name:
- Receptor-type tyrosine-protein phosphatase kappa
- Protein Accession:
- Q15262
- B2RTQ8
- B7ZMG0
- Q14763
- Q5TG10
- Q5TG11
Protein attributes for PTPRK Gene
- Size:
- 1439 amino acids
- Molecular mass:
- 162102 Da
- Quaternary structure:
- No Data Available
Protein Expression for PTPRK Gene
Selected DME Specific Peptides for PTPRK Gene
Post-translational modifications for PTPRK Gene
- This protein undergoes proteolytic processing.
- Glycosylation at Asn 101, Asn 140, Asn 211, Asn 416, Asn 424, Asn 436, Asn 462, Asn 552, Asn 586, Asn 590, Asn 607, and Asn 690
- Modification sites at PhosphoSitePlus
Other Protein References for PTPRK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PTPRK
- Abcam antibodies for PTP kappa
- Invitrogen Antibodies for PTPRK
- antibodies-online Antibodies for PTPRK: See all 3
- Search GeneTex for Antibodies for PTPRK
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTPRK
Protein Products
-
OriGene Purified Proteins for PTPRK
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPRK
- Origene Custom Protein Services for PTPRK
-
Cloud-Clone Corp. Proteins for PTPRK
- antibodies-online Proteins for PTPRK: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PTPRK
Assay Products
- antibodies-online Kits for PTPRK: See all 28
Domains & Families for PTPRK Gene
Gene Families for PTPRK Gene
Protein Domains for PTPRK Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PTPRK Gene
- GenScript: Design optimal peptide antigens:
-
- Receptor-type tyrosine-protein phosphatase kappa (PTPRK_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JRN8_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JRZ3_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JT32_HUMAN)
- Protein tyrosine phosphatase, receptor type, K (Q5JT33_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15262UniProtKB/Swiss-Prot:
PTPRK_HUMAN :- Contains 4 fibronectin type-III domains.
- Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
- Domain:
-
- Contains 4 fibronectin type-III domains.
- Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
- Contains 1 MAM domain.
- Contains 2 tyrosine-protein phosphatase domains.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Function for PTPRK Gene
Molecular function for PTPRK Gene
- GENATLAS Biochemistry:
- protein tyrosine phosphatase receptor type,kappa polypeptide,expressed in spleen,prostate,ovary,keratinocytes,epidermal cell lines
- UniProtKB/Swiss-Prot CatalyticActivity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- UniProtKB/Swiss-Prot Function:
- Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
Enzyme Numbers (IUBMB) for PTPRK Gene
- EC 3.1.3.48 63 4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004725 | protein tyrosine phosphatase activity | IEA,IDA | 8663237 |
| GO:0045295 | gamma-catenin binding | IPI | 8663237 |
Phenotypes for PTPRK Gene
- GenomeRNAi human phenotypes for PTPRK:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PTPRK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTPRK gene
- Search ViGene Biosciences for PTPRK
CRISPR Products
-
OriGene CRISPR knockouts for PTPRK
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPRK
- GenScript: Design CRISPR guide RNA sequences for PTPRK
miRNA for PTPRK Gene
- miRTarBase miRNAs that target PTPRK
-
- hsa-mir-30a-5p (MIRT005161)
- hsa-mir-133b (MIRT007126)
- hsa-mir-9-5p (MIRT021457)
- hsa-mir-935 (MIRT036651)
- hsa-mir-877-3p (MIRT037091)
- hsa-mir-615-3p (MIRT039631)
- hsa-mir-423-3p (MIRT042465)
- hsa-mir-149-5p (MIRT045592)
- hsa-mir-218-5p (MIRT439860)
- hsa-mir-1283 (MIRT546895)
- hsa-mir-7849-3p (MIRT546896)
- hsa-mir-548c-3p (MIRT546897)
miRNA Products
- Search ViGene Biosciences for PTPRK
Clone Products
- OriGene clones in human for PTPRK
- OriGene ORF clones in human,mouse,rat for PTPRK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping cDNA clones in your preferred vector
- XM_011536014
- XM_011536015
- XM_011536016
- XM_006715537
- XM_011536017
- XM_011536018
- XM_011536019
- XM_011536020
- XM_011536021
- XM_011546488
- XM_011546489
- XM_011546490
- XM_006725019
- XM_011546491
- XM_011546492
- XM_011546493
- XM_011546494
- XM_011546495
- NM_002844
- NM_001135648
- NM_001291982
- NM_001291983
- NM_001291984
- NM_001291981
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PTPRK gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PTPRK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTPRK gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTPRK Gene
Localization for PTPRK Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTPRK Gene
- Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 1 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001750 | photoreceptor outer segment | IEA | -- |
| GO:0030425 | dendrite | IEA | -- |
| GO:0043025 | neuronal cell body | IEA | -- |
Pathways & Interactions for PTPRK Gene
More details on SuperPathways for PTPRK| Superpath | Contained pathways | |
|---|---|---|
| 1 | PAK Pathway | |
| 2 | EGFR downregulation | |
| 3 | Signaling by GPCR | |
| 4 | Interleukin-3, 5 and GM-CSF signaling | |
| 5 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Pathways by source for PTPRK Gene
1 BioSystems pathway for PTPRK Gene
3 Reactome pathways for PTPRK Gene
1 Qiagen pathway for PTPRK Gene
Interacting Proteins for PTPRK Gene
Selected Interacting proteins:
Q15262-PTPRK_HUMAN
ENSP00000357196
for PTPRK Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IEA,IDA | 16263724 |
| GO:0007155 | cell adhesion | IMP | 15899872 |
| GO:0008285 | negative regulation of cell proliferation | IDA | 15899872 |
| GO:0010839 | negative regulation of keratinocyte proliferation | IDA | 16263724 |
| GO:0016477 | cell migration | IMP | 15899872 |
No data available for SIGNOR curated interactions for PTPRK Gene
Drugs & Compounds for PTPRK Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14265-44-2 |
|
|||
| phosphoric acid |
|
7664-38-2 |
|
|||
| Water |
|
7732-18-5 |
|
Transcripts for PTPRK Gene
mRNA/cDNA for PTPRK Gene
- (24) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (196) Selected AceView cDNA sequences:
- (22) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PTPRK Gene
- Protein tyrosine phosphatase, receptor type, K:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PTPRK
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPRK
- GenScript: Design CRISPR guide RNA sequences for PTPRK
miRNA Products
- Search ViGene Biosciences for PTPRK
Clone Products
- OriGene clones in human for PTPRK
- OriGene ORF clones in human,mouse,rat for PTPRK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping cDNA clones in your preferred vector
- XM_011536014
- XM_011536015
- XM_011536016
- XM_006715537
- XM_011536017
- XM_011536018
- XM_011536019
- XM_011536020
- XM_011536021
- XM_011546488
- XM_011546489
- XM_011546490
- XM_006725019
- XM_011546491
- XM_011546492
- XM_011546493
- XM_011546494
- XM_011546495
- NM_002844
- NM_001135648
- NM_001291982
- NM_001291983
- NM_001291984
- NM_001291981
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36a | · | 36b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for PTPRK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
- Mature B-Cells Peripheral Blood
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Gall Bladder (Hepatobiliary System)
This gene is overexpressed in Amniocyte (16.9) and Breast (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRK Gene
SOURCE GeneReport for Unigene cluster for PTPRK Gene Hs.155919
mRNA Expression by UniProt/SwissProt for PTPRK Gene
Q15262-PTPRK_HUMAN
Tissue specificity:
High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.
Primer Products
-
OriGene qPCR primer pairs for PTPRK
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PTPRK Gene
Orthologs for PTPRK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | PTPRK 35 |
|
||
| PTPRK 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | PTPRK 35 |
|
||
| PTPRK 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ptprk 35 |
|
||
| Ptprk 16 |
|
||||
| Ptprk 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | PTPRK 35 |
|
||
| PTPRK 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ptprk 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PTPRK 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PTPRK 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PTPRK 35 |
|
||
| PTPRK 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | PTPRK 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ptprk 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | -- 35 |
|
||
| ptprk 35 |
|
||||
| ptprk 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7180 37 |
|
|
|
| Ptp52F 37 |
|
|
|||
| Ptp69D 37 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | C55B7.3 37 |
|
|
|
| F10G8.1 37 |
|
|
|||
| F47B3.7 37 |
|
|
|||
| T22C1.8 37 |
|
|
|||
| T27A3.5 37 |
|
|
|||
| Y48G9A.9 37 |
|
|
|||
| ZK484.7 37 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1390 36 |
|
OneToMany |
- Species with no ortholog for PTPRK:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PTPRK Gene
Paralogs for PTPRK Gene
(31) SIMAP similar genes for PTPRK Gene using alignment to 13 proteins:
Variants for PTPRK Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1012049 | -- | 128,209,162(+) | AACGC(A/G)CCATT | intron-variant | |
| rs1012629 | -- | 128,448,755(-) | GATAA(A/C)CCCTC | intron-variant | |
| rs1016015 | -- | 128,507,123(+) | gcagt(C/T)aagtt | intron-variant | |
| rs1016218 | -- | 128,457,936(+) | AATTA(C/T)GCCAT | intron-variant | |
| rs1050590 | -- | 128,242,576(-) | TCAGG(A/G)GGGAG | reference, synonymous-codon |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv483139 | CNV | Gain | 15286789 |
| nsv7967 | CNV | Gain | 18304495 |
| nsv5470 | CNV | Insertion | 18451855 |
| nsv510906 | CNV | Complex | 20534489 |
| esv990030 | CNV | Insertion | 20482838 |
| esv1288742 | CNV | Insertion | 17803354 |
| nsv886649 | CNV | Loss | 21882294 |
| nsv516794 | CNV | Loss | 19592680 |
| nsv886650 | CNV | Gain | 21882294 |
| nsv5471 | CNV | Loss | 18451855 |
| nsv528869 | CNV | Loss | 19592680 |
| esv2668728 | CNV | Deletion | 23128226 |
| esv24443 | CNV | Loss | 19812545 |
| dgv6991n71 | CNV | Loss | 21882294 |
| nsv886652 | CNV | Loss | 21882294 |
| esv2676123 | CNV | Deletion | 23128226 |
| nsv830800 | CNV | Gain | 17160897 |
| esv2732686 | CNV | Deletion | 23290073 |
| esv268724 | CNV | Insertion | 20981092 |
| esv2732687 | CNV | Deletion | 23290073 |
| esv25848 | CNV | Loss | 19812545 |
| esv2658020 | CNV | Deletion | 23128226 |
| nsv516115 | CNV | Loss | 19592680 |
Residual Variation Intolerance Score:
5.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.89;
48.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PTPRK Gene
- Human Gene Mutation Database (HGMD)
- PTPRK
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRK Gene
Disorders for PTPRK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| eye lymphoma |
|
|
Search PTPRK in MalaCards
View complete list of genes associated with diseases
Relevant External Links for PTPRK
No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRK Gene
Publications for PTPRK Gene
- Molecular cloning and chromosomal localization of a human gene homologous to the murine R-PTP-kappa, a receptor-type protein tyrosine phosphatase. (PMID: 9047348) Yang Y. … Ha H. (Gene 1997) 2 3 4 23 67
- Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. (PMID: 8663237) Fuchs M. … Ullrich A. (J. Biol. Chem. 1996) 2 3 23
- Receptor type protein tyrosine phosphatase-kappa mediates cross-talk between transforming growth factor-beta and epidermal growth factor receptor signaling pathways in human keratinocytes. (PMID: 19864455) Xu Y. … Fisher G.J. (Mol. Biol. Cell 2010) 3 23
- The effect of receptor protein tyrosine phosphatase kappa on the change of cell adhesion and proliferation induced by N-acetylglucosaminyltransferase V. (PMID: 19911372) Wang C. … Zha X. (J. Cell. Biochem. 2010) 3 23
- EGF-mediated migration signaling activated by N-acetylglucosaminyltransferase-V via receptor protein tyrosine phosphatase kappa. (PMID: 19236842) Wang C. … Zha X. (Arch. Biochem. Biophys. 2009) 3 23
Products for PTPRK Gene
- Browse R&D Systems for Antibodies
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- Custom Assay Services
- OriGene Purified Proteins for PTPRK
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPRK
- Origene Custom Protein Services for PTPRK
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for PTPRK
- Browse OriGene Inhibitory RNA Products For PTPRK
- OriGene qPCR primer pairs for PTPRK
- OriGene CRISPR knockouts for PTPRK
- OriGene clones in human for PTPRK
- OriGene ORF clones in human,mouse,rat for PTPRK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- XM_011536014
- XM_011536015
- XM_011536016
- XM_006715537
- XM_011536017
- XM_011536018
- XM_011536019
- XM_011536020
- XM_011536021
- XM_011546488
- XM_011546489
- XM_011546490
- XM_006725019
- XM_011546491
- XM_011546492
- XM_011546493
- XM_011546494
- XM_011546495
- NM_002844
- NM_001135648
- NM_001291982
- NM_001291983
- NM_001291984
- NM_001291981
- GenScript Custom Purified and Recombinant Proteins Services for PTPRK
- GenScript Custom Assay Services for PTPRK
- GenScript Custom overexpressing Cell Line Services for PTPRK
- GenScript: Design CRISPR guide RNA sequences for PTPRK
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PTPRK
- Novus Biologicals Antibodies for PTPRK
- Novus Biologicals proteins and lysates for PTPRK
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies at Cloud-Clone Corp.
- Cloud-Clone Corp. Proteins for PTPRK
- Browse Assay Kits at Cloud-Clone Corp.
- antibodies-online Antibodies for PTPRK: See all 3
- antibodies-online Kits for PTPRK: See all 28
- antibodies-online Proteins for PTPRK: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for PTPRK
- Search GeneTex for Proteins for PTPRK
- ViGene Biosciences adenoviral particle packaged cDNA for PTPRK gene
- ViGene Biosciences lentiviral particle packaged cDNA for PTPRK gene
- ViGene Biosciences lentiviral particle packaged cDNA for PTPRK gene
- ViGene Biosciences ready-to-package AAV shRNAs for PTPRK gene
- ViGene Biosciences ready-to-package AAV shRNAs for PTPRK gene
- ViGene Biosciences ready-to-package AAV shRNAs for PTPRK gene
- Search ViGene Biosciences for PTPRK
- Search ViGene Biosciences for PTPRK
- Santa Cruz Biotechnology (SCBT) Antibodies for PTPRK
- Search Santa Cruz Biotechnology (SCBT) for PTPRK siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PTPRK
Sources for PTPRK Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon