Aliases for PTPRK Gene
- Protein Tyrosine Phosphatase, Receptor Type K 2 3
- Protein Tyrosine Phosphatase, Receptor Type, K 3 5
- Protein-Tyrosine Phosphatase Kappa 3 4
- R-PTP-Kappa 3 4
- EC 126.96.36.199 4 63
- DJ480J14.2.1 (Protein Tyrosine Phosphatase, Receptor Type, K (R-PTP-KAPPA, Protein Tyrosine Phosphatase Kappa , Protein Tyrosine Phosphatase Kappa 3
- Protein-Tyrosine Phosphatase, Receptor Type, Kappa 3
- PTPK 4
External Ids for PTPRK Gene
Previous GeneCards Identifiers for PTPRK Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPRK Gene
PTPRK (Protein Tyrosine Phosphatase, Receptor Type K) is a Protein Coding gene. Diseases associated with PTPRK include Eye Lymphoma. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and EGFR downregulation. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRS.
UniProtKB/Swiss-Prot for PTPRK Gene
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.