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Aliases for PTPRK Gene

Aliases for PTPRK Gene

  • Protein Tyrosine Phosphatase, Receptor Type, K 2 3
  • Protein-Tyrosine Phosphatase Kappa 3 4
  • R-PTP-Kappa 3 4
  • EC 3.1.3.48 4 63
  • DJ480J14.2.1 (Protein Tyrosine Phosphatase, Receptor Type, K (R-PTP-KAPPA, Protein Tyrosine Phosphatase Kappa , Protein Tyrosine Phosphatase Kappa 3
  • Protein-Tyrosine Phosphatase, Receptor Type, Kappa 3
  • PTPK 4

External Ids for PTPRK Gene

Previous GeneCards Identifiers for PTPRK Gene

  • GC06M128137
  • GC06M128270
  • GC06M128331
  • GC06M125866
  • GC06M128289

Summaries for PTPRK Gene

Entrez Gene Summary for PTPRK Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRK Gene

PTPRK (Protein Tyrosine Phosphatase, Receptor Type, K) is a Protein Coding gene. Diseases associated with PTPRK include eye lymphoma. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRT.

UniProtKB/Swiss-Prot for PTPRK Gene

  • Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.

Gene Wiki entry for PTPRK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRK Gene

Genomics for PTPRK Gene

Regulatory Elements for PTPRK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPRK Gene

Chromosome:
6
Start:
127,968,779 bp from pter
End:
128,520,847 bp from pter
Size:
552,069 bases
Orientation:
Minus strand

Genomic View for PTPRK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRK Gene

Proteins for PTPRK Gene

  • Protein details for PTPRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15262-PTPRK_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase kappa
    Protein Accession:
    Q15262
    Secondary Accessions:
    • B2RTQ8
    • B7ZMG0
    • Q14763
    • Q5TG10
    • Q5TG11

    Protein attributes for PTPRK Gene

    Size:
    1439 amino acids
    Molecular mass:
    162102 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPRK Gene

    Alternative splice isoforms for PTPRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRK Gene

Proteomics data for PTPRK Gene at MOPED

Post-translational modifications for PTPRK Gene

  • This protein undergoes proteolytic processing
  • Glycosylation at Asn 101, Asn 140, Asn 211, Asn 416, Asn 424, Asn 436, Asn 462, Asn 552, Asn 586, Asn 590, Asn 607, and Asn 690
  • Modification sites at PhosphoSitePlus

Domains & Families for PTPRK Gene

Graphical View of Domain Structure for InterPro Entry

Q15262

UniProtKB/Swiss-Prot:

PTPRK_HUMAN :
  • Contains 4 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Domain:
  • Contains 4 fibronectin type-III domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 MAM domain.
  • Contains 2 tyrosine-protein phosphatase domains.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
genes like me logo Genes that share domains with PTPRK: view

Function for PTPRK Gene

Molecular function for PTPRK Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase receptor type,kappa polypeptide,expressed in spleen,prostate,ovary,keratinocytes,epidermal cell lines
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.

Enzyme Numbers (IUBMB) for PTPRK Gene

Gene Ontology (GO) - Molecular Function for PTPRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IDA 8663237
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity NAS 9047348
GO:0005515 protein binding IPI 15899872
GO:0008013 beta-catenin binding IPI 8663237
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPRK: view
genes like me logo Genes that share phenotypes with PTPRK: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRK

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PTPRK Gene

Localization for PTPRK Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRK Gene

Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRK Gene COMPARTMENTS Subcellular localization image for PTPRK gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PTPRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0005887 integral component of plasma membrane NAS 9047348
GO:0005911 cell-cell junction IDA 8663237
GO:0005912 adherens junction IEA --
GO:0009986 cell surface IDA 18276111
genes like me logo Genes that share ontologies with PTPRK: view

Pathways & Interactions for PTPRK Gene

genes like me logo Genes that share pathways with PTPRK: view

Pathways by source for PTPRK Gene

1 Qiagen pathway for PTPRK Gene
3 Reactome pathways for PTPRK Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IDA 16263724
GO:0007155 cell adhesion IMP 15899872
GO:0007165 signal transduction IDA 16849327
GO:0007179 transforming growth factor beta receptor signaling pathway IDA 15899872
GO:0008285 negative regulation of cell proliferation IDA 15899872
genes like me logo Genes that share ontologies with PTPRK: view

No data available for SIGNOR curated interactions for PTPRK Gene

Drugs & Compounds for PTPRK Gene

(1) Drugs for PTPRK Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tyrosine Nutra 547

(3) Additional Compounds for PTPRK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTPRK: view

Transcripts for PTPRK Gene

Unigene Clusters for PTPRK Gene

Protein tyrosine phosphatase, receptor type, K:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4:
SP5:
SP6: - -
SP7: - -
SP8:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PTPRK Gene

GeneLoc Exon Structure for
PTPRK
ECgene alternative splicing isoforms for
PTPRK

Expression for PTPRK Gene

mRNA expression in normal human tissues for PTPRK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPRK Gene

This gene is overexpressed in Amniocyte (16.9) and Breast (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRK Gene



SOURCE GeneReport for Unigene cluster for PTPRK Gene Hs.155919

mRNA Expression by UniProt/SwissProt for PTPRK Gene

Q15262-PTPRK_HUMAN
Tissue specificity: High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma
genes like me logo Genes that share expression patterns with PTPRK: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PTPRK Gene

Orthologs for PTPRK Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRK 35
  • 93.42 (n)
  • 99.45 (a)
PTPRK 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRK 35
  • 92.23 (n)
  • 99.49 (a)
PTPRK 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprk 35
  • 89.9 (n)
  • 99.02 (a)
Ptprk 16
Ptprk 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPRK 35
  • 99.63 (n)
  • 99.93 (a)
PTPRK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprk 35
  • 88.61 (n)
  • 98.8 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPRK 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRK 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRK 35
  • 83.73 (n)
  • 96.06 (a)
PTPRK 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRK 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprk 35
  • 79.61 (n)
  • 93.4 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ptprk 35
  • 73.49 (n)
  • 85.75 (a)
ptprk 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7180 37
  • 34 (a)
Ptp52F 37
  • 43 (a)
Ptp69D 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea C55B7.3 37
  • 33 (a)
F10G8.1 37
  • 31 (a)
F47B3.7 37
  • 35 (a)
T22C1.8 37
  • 34 (a)
T27A3.5 37
  • 34 (a)
Y48G9A.9 37
  • 34 (a)
ZK484.7 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1390 36
  • 39 (a)
OneToMany
Species with no ortholog for PTPRK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRK Gene

ENSEMBL:
Gene Tree for PTPRK (if available)
TreeFam:
Gene Tree for PTPRK (if available)

Paralogs for PTPRK Gene

Paralogs for PTPRK Gene

genes like me logo Genes that share paralogs with PTPRK: view

Variants for PTPRK Gene

Sequence variations from dbSNP and Humsavar for PTPRK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs717851 -- 128,003,096(-) GCTTG(A/G)TTTTG intron-variant
rs722796 -- 128,412,548(+) CAACA(A/T)GCTGG intron-variant
rs730202 -- 128,240,522(+) TCAGA(A/G)CCTAA intron-variant
rs742736 -- 128,240,456(+) GATGA(C/T)AATAA intron-variant
rs802718 -- 127,968,366(-) CATTC(C/T)TACTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PTPRK Gene

Variant ID Type Subtype PubMed ID
nsv483139 CNV Gain 15286789
nsv7967 CNV Gain 18304495
nsv5470 CNV Insertion 18451855
nsv510906 CNV Complex 20534489
esv990030 CNV Insertion 20482838
esv1288742 CNV Insertion 17803354
nsv886649 CNV Loss 21882294
nsv516794 CNV Loss 19592680
nsv886650 CNV Gain 21882294
nsv5471 CNV Loss 18451855
nsv528869 CNV Loss 19592680
esv2668728 CNV Deletion 23128226
esv24443 CNV Loss 19812545
dgv6991n71 CNV Loss 21882294
nsv886652 CNV Loss 21882294
esv2676123 CNV Deletion 23128226
nsv830800 CNV Gain 17160897
esv2732686 CNV Deletion 23290073
esv268724 CNV Insertion 20981092
esv2732687 CNV Deletion 23290073
esv25848 CNV Loss 19812545
esv2658020 CNV Deletion 23128226
nsv516115 CNV Loss 19592680

Variation tolerance for PTPRK Gene

Residual Variation Intolerance Score: 5.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRK Gene

HapMap Linkage Disequilibrium report
PTPRK
Human Gene Mutation Database (HGMD)
PTPRK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRK Gene

Disorders for PTPRK Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTPRK Gene - From: DISEASES

Disorder Aliases PubMed IDs
eye lymphoma
  • lymphoma of eye
- elite association
Search PTPRK in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPRK

Genetic Association Database (GAD)
PTPRK
Human Genome Epidemiology (HuGE) Navigator
PTPRK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRK
genes like me logo Genes that share disorders with PTPRK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRK Gene

Publications for PTPRK Gene

  1. Molecular cloning and chromosomal localization of a human gene homologous to the murine R-PTP-kappa, a receptor-type protein tyrosine phosphatase. (PMID: 9047348) Yang Y. … Ha H. (Gene 1997) 2 23 67
  2. Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. (PMID: 8663237) Fuchs M. … Ullrich A. (J. Biol. Chem. 1996) 2 23 67
  3. Receptor type protein tyrosine phosphatase-kappa mediates cross-talk between transforming growth factor-beta and epidermal growth factor receptor signaling pathways in human keratinocytes. (PMID: 19864455) Xu Y. … Fisher G.J. (Mol. Biol. Cell 2010) 23 67
  4. Comparative quantitation of aberrant glycoforms by lectin-based glycoprotein enrichment coupled with multiple-reaction monitoring mass spectrometry. (PMID: 20462175) Ahn Y.H. … Yoo J.S. (Anal. Chem. 2010) 23 67
  5. The effect of receptor protein tyrosine phosphatase kappa on the change of cell adhesion and proliferation induced by N-acetylglucosaminyltransferase V. (PMID: 19911372) Wang C. … Zha X. (J. Cell. Biochem. 2010) 23 67

Products for PTPRK Gene

Sources for PTPRK Gene

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