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Aliases for PTPRJ Gene

Aliases for PTPRJ Gene

  • Protein Tyrosine Phosphatase, Receptor Type, J 2 3
  • DEP1 3 4 6
  • Protein-Tyrosine Phosphatase Receptor Type J 3 4
  • Protein-Tyrosine Phosphatase Eta 3 4
  • Density-Enhanced Phosphatase 1 3 4
  • CD148 Antigen 3 4
  • EC 3.1.3.48 4 63
  • R-PTP-ETA 3 4
  • HPTP Eta 3 4
  • R-PTP-J 3 4
  • DEP-1 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, J Polypeptide 3
  • Susceptibility To Colon Cancer 1, Mouse, Homolog Of 3
  • Receptor-Type Tyrosine-Protein Phosphatase Eta 3
  • Human Density Enhanced Phosphatase-1 3
  • HPTPeta 3
  • CD148 3
  • SCC1 3

External Ids for PTPRJ Gene

Previous GeneCards Identifiers for PTPRJ Gene

  • GC11P049914
  • GC11P048896
  • GC11P048033
  • GC11P047966
  • GC11P047958
  • GC11P047712

Summaries for PTPRJ Gene

Entrez Gene Summary for PTPRJ Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRJ Gene

PTPRJ (Protein Tyrosine Phosphatase, Receptor Type, J) is a Protein Coding gene. Diseases associated with PTPRJ include lymphoblastic lymphoma and precursor b lymphoblastic lymphoma/leukemia. Among its related pathways are PAK Pathway and PDGFR-beta signaling pathway. GO annotations related to this gene include protein kinase binding and beta-catenin binding. An important paralog of this gene is PTPRO.

UniProtKB/Swiss-Prot for PTPRJ Gene

  • Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Gene Wiki entry for PTPRJ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRJ Gene

Genomics for PTPRJ Gene

Regulatory Elements for PTPRJ Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPRJ Gene

Start:
47,980,558 bp from pter
End:
48,170,842 bp from pter
Size:
190,285 bases
Orientation:
Plus strand

Genomic View for PTPRJ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRJ Gene

Proteins for PTPRJ Gene

  • Protein details for PTPRJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12913-PTPRJ_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase eta
    Protein Accession:
    Q12913
    Secondary Accessions:
    • Q15255
    • Q6P4H4
    • Q8NHM2
    • Q9UDA9

    Protein attributes for PTPRJ Gene

    Size:
    1337 amino acids
    Molecular mass:
    145941 Da
    Quaternary structure:
    • Monomer. Interacts with CTNNB1 (phosphorylated) and JUP (phosphorylated). Interacts with FLT3 (phosphorylated). Interacts with GAB1 and GRB2.

    Three dimensional structures from OCA and Proteopedia for PTPRJ Gene

    Alternative splice isoforms for PTPRJ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRJ Gene

Proteomics data for PTPRJ Gene at MOPED

Selected DME Specific Peptides for PTPRJ Gene

Post-translational modifications for PTPRJ Gene

  • N- and O-glycosylated.
  • Glycosylation at Asn72, Asn82, Asn93, Asn104, Asn142, Asn172, Asn192, Asn231, Asn258, Asn278, Asn342, Asn351, Asn376, Asn391, Asn396, Asn413, Asn431, Asn501, Asn525, Asn536, Asn582, Asn603, Asn618, Asn628, Asn637, Asn666, Asn669, Asn761, Asn772, Asn784, Asn790, Asn824, Asn910, and Asn937
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPRJ Gene

Antibody Products

Domains for PTPRJ Gene

Gene Families for PTPRJ Gene

HGNC:
  • CD :CD molecules
  • FN3 :Fibronectin type III domain containing
  • PTPR :Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like
IUPHAR :

Suggested Antigen Peptide Sequences for PTPRJ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12913

UniProtKB/Swiss-Prot:

PTPRJ_HUMAN :
  • Q12913
Domain:
  • Contains 9 fibronectin type-III domains.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
genes like me logo Genes that share domains with PTPRJ: view

Function for PTPRJ Gene

Molecular function for PTPRJ Gene

GENATLAS Biochemistry: protein tyrosine kinase,receptor type,J polypeptide
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Enzyme Numbers (IUBMB) for PTPRJ Gene

Gene Ontology (GO) - Molecular Function for PTPRJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IMP 12475979
GO:0005161 platelet-derived growth factor receptor binding IPI 10821867
GO:0005515 protein binding IPI 10821867
GO:0008013 beta-catenin binding IPI 12370829
GO:0016791 phosphatase activity IMP 11259588
genes like me logo Genes that share ontologies with PTPRJ: view
genes like me logo Genes that share phenotypes with PTPRJ: view

Animal Models for PTPRJ Gene

MGI Knock Outs for PTPRJ:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRJ

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PTPRJ Gene

Localization for PTPRJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRJ Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRJ Gene COMPARTMENTS Subcellular localization image for PTPRJ gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PTPRJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 12913111
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0005887 integral component of plasma membrane TAS 7937872
GO:0005911 cell-cell junction IDA 12370829
genes like me logo Genes that share ontologies with PTPRJ: view

Pathways for PTPRJ Gene

genes like me logo Genes that share pathways with PTPRJ: view

Pathways by source for PTPRJ Gene

1 KEGG pathway for PTPRJ Gene
1 GeneGo (Thomson Reuters) pathway for PTPRJ Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPRJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001954 positive regulation of cell-matrix adhesion --
GO:0006470 protein dephosphorylation --
GO:0007507 heart development IEA --
GO:0007596 blood coagulation IEA --
genes like me logo Genes that share ontologies with PTPRJ: view

Compounds for PTPRJ Gene

(1) HMDB Compounds for PTPRJ Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2

(5) Novoseek inferred chemical compound relationships for PTPRJ Gene

Compound -log(P) Hits PubMed IDs
tyrosine 69.8 51
threonine 22.1 4
serine 6.24 3
calcium 0 2
superoxide 0 1
genes like me logo Genes that share compounds with PTPRJ: view

Transcripts for PTPRJ Gene

Unigene Clusters for PTPRJ Gene

Protein tyrosine phosphatase, receptor type, J:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRJ

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PTPRJ

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRJ Gene

No ASD Table

Relevant External Links for PTPRJ Gene

GeneLoc Exon Structure for
PTPRJ
ECgene alternative splicing isoforms for
PTPRJ

Expression for PTPRJ Gene

mRNA expression in normal human tissues for PTPRJ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRJ Gene

This gene is overexpressed in Whole Blood (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRJ Gene

SOURCE GeneReport for Unigene cluster for PTPRJ Gene Hs.318547

mRNA Expression by UniProt/SwissProt for PTPRJ Gene

Q12913-PTPRJ_HUMAN
Tissue specificity: Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density.
genes like me logo Genes that share expressions with PTPRJ: view

In Situ Assay Products

Orthologs for PTPRJ Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRJ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRJ 35
  • 99.32 (n)
  • 98.7 (a)
PTPRJ 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRJ 35
  • 78.67 (n)
  • 71.54 (a)
PTPRJ 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRJ 35
  • 79.56 (n)
  • 72.17 (a)
PTPRJ 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprj 35
  • 77.71 (n)
  • 72.7 (a)
Ptprj 16
Ptprj 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPRJ 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRJ 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprj 35
  • 77.48 (n)
  • 73.38 (a)
chicken
(Gallus gallus)
Aves PTPRJ 35
  • 56.22 (n)
  • 49.79 (a)
PTPRJ 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRJ 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PTPRJ (2 of 3) 36
  • 25 (a)
OneToMany
ptprja 35
  • 49.65 (n)
  • 39.77 (a)
ptprja 36
  • 24 (a)
OneToMany
ptprjb 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 36
  • 18 (a)
OneToMany
Ptp52F 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.31 36
  • 30 (a)
OneToMany
ZK354.8 37
  • 32 (a)
F47B3.6 37
  • 35 (a)
Y41D4A.5 37
  • 29 (a)
T22C1.8 37
  • 32 (a)
F47B3.1 37
  • 35 (a)
F36H1.3 37
  • 36 (a)
Y48G9A.9 37
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3156 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
Species with no ortholog for PTPRJ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPRJ Gene

ENSEMBL:
Gene Tree for PTPRJ (if available)
TreeFam:
Gene Tree for PTPRJ (if available)

Paralogs for PTPRJ Gene

Paralogs for PTPRJ Gene

Pseudogenes.org Pseudogenes for PTPRJ Gene

genes like me logo Genes that share paralogs with PTPRJ: view

Variants for PTPRJ Gene

Sequence variations from dbSNP and Humsavar for PTPRJ Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs900696 -- 47,979,091(+) caccc(C/T)gttgc upstream-variant-2KB
rs900697 -- 48,018,960(-) TAACT(C/G)GACTC intron-variant
rs900698 -- 48,018,128(-) ACTTA(A/G)AAGGA intron-variant
rs900699 -- 48,018,082(-) CCTCT(A/G)TTTTC intron-variant
rs900700 -- 48,003,193(-) AGTAC(A/C)TCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRJ Gene

Variant ID Type Subtype PubMed ID
nsv897326 CNV Gain 21882294
nsv317 CNV Loss 18451855
nsv528641 CNV Loss 19592680
dgv1091n71 CNV Gain 21882294
nsv39746 CNV Loss 16902084
nsv897329 CNV Gain 21882294
esv2657950 CNV Deletion 23128226
nsv467871 CNV Gain 19166990
esv2458591 CNV Deletion 19546169
esv2380235 CNV Deletion 18987734
esv3499 CNV Deletion 18987735
esv2744445 CNV Deletion 23290073
esv1002186 CNV Deletion 20482838
esv990562 CNV Deletion 20482838
esv7637 CNV Loss 19470904
esv2674478 CNV Deletion 23128226
nsv428253 CNV Loss 18775914

Relevant External Links for PTPRJ Gene

HapMap Linkage Disequilibrium report
PTPRJ
Human Gene Mutation Database (HGMD)
PTPRJ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRJ Gene

Disorders for PTPRJ Gene

(1) OMIM Diseases for PTPRJ Gene (600925)

(1) University of Copenhagen DISEASES for PTPRJ Gene

(8) Novoseek inferred disease relationships for PTPRJ Gene

Disease -log(P) Hits PubMed IDs
thyroid carcinoma 40.8 4
neoplastic transformation 34.3 2
colon cancer 27.7 4
adenoma 19.2 1
tumors 15.9 13

Relevant External Links for PTPRJ

Genetic Association Database (GAD)
PTPRJ
Human Genome Epidemiology (HuGE) Navigator
PTPRJ
genes like me logo Genes that share disorders with PTPRJ: view

No data available for UniProtKB/Swiss-Prot for PTPRJ Gene

Publications for PTPRJ Gene

  1. Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. (PMID: 7937872) Oestman A. … Tonks N.K. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta. (PMID: 7994032) Honda H. … Hirai H. (Blood 1994) 2 3 4 23
  3. The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis. (PMID: 15378013) Iuliano R. … Fusco A. (Oncogene 2004) 3 4 23 48
  4. DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients. (PMID: 16682945) Balavenkatraman K.K. … Bohmer F.D. (Oncogene 2006) 3 4 23
  5. The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins. (PMID: 16778204) Iervolino A. … Fusco A. (Cancer Res. 2006) 3 4 23

Products for PTPRJ Gene

  • Addgene plasmids for PTPRJ

Sources for PTPRJ Gene

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