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PTPRJ Gene

protein-coding   GIFtS: 71
GCID: GC11P048002

Protein Tyrosine Phosphatase, Receptor Type, J

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Receptor Type, J1 2     CD1482
DEP12 3 5     HPTPeta2
Density-Enhanced Phosphatase 12 3     R-PTP-ETA2
Protein-Tyrosine Phosphatase Eta2 3     SCC12
Protein-Tyrosine Phosphatase Receptor Type J2 3     Human Density Enhanced Phosphatase-12
DEP-12 3     Protein Tyrosine Phosphatase, Receptor Type, J Polypeptide2
R-PTP-J2 3     Receptor-Type Tyrosine-Protein Phosphatase Eta2
CD148 Antigen2 3     Susceptibility To Colon Cancer 1, Mouse, Homolog Of2
HPTP Eta2 3     R-PTP-eta3
EC 3.1.3.483 8     

External Ids:    HGNC: 96731   Entrez Gene: 57952   Ensembl: ENSG000001491777   OMIM: 6009255   UniProtKB: Q129133   

Export aliases for PTPRJ gene to outside databases

Previous GC identifers: GC11P049914 GC11P048896 GC11P048033 GC11P047966 GC11P047958 GC11P047712


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPRJ Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five
fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and
thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to
negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of
Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta
receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTPRJ Gene:
PTPRJ (protein tyrosine phosphatase, receptor type, J) is a protein-coding gene. Diseases associated with PTPRJ include lymphoblastic lymphoma, and precursor b lymphoblastic lymphoma/leukemia. GO annotations related to this gene include beta-catenin binding and protein kinase binding. An important paralog of this gene is PTPRQ.

UniProtKB/Swiss-Prot: PTPRJ_HUMAN, Q12913
Function: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3,
PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role
in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of
macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet
activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell
migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of
VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway;
through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly.
Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded
from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer
excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling

Gene Wiki entry for PTPRJ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPRJ gene promoter:
         TBP   Spz1   Nkx5-1   PPAR-gamma1   c-Rel   CP2   HOXA5   PPAR-gamma2   AP-2alphaA   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPRJ promoter sequence
   Search Chromatin IP Primers for PTPRJ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPRJ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

PTPRJ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRJ gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P048002:  view genomic region     (about GC identifiers)

Start:
48,002,110 bp from pter      End:
48,192,394 bp from pter
Size:
190,285 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PTPRJ_HUMAN, Q12913 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein phosphatase eta precursor  
Size: 1337 amino acids; 145941 Da
Subunit: Monomer. Interacts with CTNNB1 (phosphorylated) and JUP (phosphorylated). Interacts with FLT3
(phosphorylated). Interacts with GAB1 and GRB2
3 PDB 3D structures from and Proteopedia for PTPRJ:
2CFV (3D)        2DLE (3D)        2NZ6 (3D)    
Secondary accessions: Q15255 Q6P4H4 Q8NHM2 Q9UDA9
Alternative splicing: 2 isoforms:  Q12913-1   Q12913-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPRJ: NX_Q12913

Explore proteomics data for PTPRJ at MOPED

Post-translational modifications: 

  • N- and O-glycosylated1
  • Glycosylation2 at Asn72, Asn82, Asn93, Asn104, Asn142, Asn172, Asn192, Asn231, Asn258, Asn278,
                                 Asn342, Asn351, Asn376, Asn391, Asn396, Asn413, Asn431, Asn501, Asn525, Asn536 (see all 34)
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTPRJ (Q12913) (see all 6)
     WPDHGVP  DYINANY  DFWRMVW  MVQTEDQY 


    See PTPRJ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091973.1  NP_002834.3  

    ENSEMBL proteins: 
     ENSP00000400010   ENSP00000409733   ENSP00000432686   ENSP00000435618  

    PTPRJ Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PTPRJ
    OriGene MassSpec for PTPRJ
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    Novus Biologicals PTPRJ Protein
    Novus Biologicals PTPRJ Lysate
    Sino Biological Recombinant Protein for PTPRJ
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for PTPRJ

    PTPRJ Antibody Products:

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    LSBio Antibodies in human, mouse, rat for PTPRJ

    PTPRJ Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    CD: CD molecules
    PTPR: Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like

    IUPHAR Guide to PHARMACOLOGY protein family classification: Type J
    Receptor tyrosine phosphatases (RTP)

    5 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR016130 Tyr_Pase_AS
     IPR013783 Ig-like_fold
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry Q12913

    ProtoNet protein and cluster: Q12913

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTPRJ_HUMAN, Q12913
    Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily
    Similarity: Contains 9 fibronectin type-III domains
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    PTPRJ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTPRJ_HUMAN, Q12913
    Function: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3,
    PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role
    in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of
    macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet
    activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell
    migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of
    VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway;
    through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly.
    Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded
    from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer
    excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPRJ:
    protein tyrosine kinase,receptor type,J polypeptide

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IMP12475979
    GO:0005161platelet-derived growth factor receptor binding IPI10821867
    GO:0005515protein binding IPI10821867
    GO:0008013beta-catenin binding IPI12370829
    GO:0016791phosphatase activity IMP11259588
         
    PTPRJ for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PTPRJ:
     Apoptosis resistance  Increased Akt phosphorylation   Increased Erk phosphorylation   Increased G2M DNA content 
     Increased gamma-H2AX phosphory 

         15 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ptprj):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     no phenotypic analysis  normal  reproductive system  respiratory system  tumorigenesis 

    PTPRJ for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PTPRJ: Ptprjtm1Fus Ptprjtm1Taka Ptprjtm1.2Weis

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTPRJ
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PTPRJ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPRJ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPRJ

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTPRJ:
    hsa-mir-26b-5p (MIRT029278), hsa-mir-328-3p (MIRT006477), hsa-mir-124-3p (MIRT022460), hsa-mir-155-5p (MIRT001514), hsa-mir-16-5p (MIRT031605), hsa-mir-31-5p (MIRT049863), hsa-mir-335-5p (MIRT017530)

    Block miRNA regulation of human, mouse, rat PTPRJ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPRJ (see all 104):
    hsa-miR-548j hsa-miR-607 hsa-miR-199a-3p hsa-miR-106a hsa-miR-15a hsa-miR-4272 hsa-miR-519a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidPTPRJ 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PTPRJ
    Predesigned siRNA for gene silencing in human, mouse, rat PTPRJ

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): PTPRJ (NM_002843)
    Sino Biological Human cDNA Clone for PTPRJ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPRJ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRJ

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRJ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTPRJ_HUMAN, Q12913: Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane (By
    similarity). Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IDA12913111
    GO:0005886plasma membrane IDA18348712
    GO:0005887integral component of plasma membrane TAS7937872
    GO:0005911cell-cell junction IDA12370829
    GO:0009986cell surface IDA12913111

    PTPRJ for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPRJ About    
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    3PDGFR-beta signaling pathway
    PDGFR-beta signaling pathway
    4Cell adhesion Cadherin mediated cell adhesion
    Cell adhesion Cadherin mediated cell adhesion
    5Adherens junction
    Adherens junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPRJ
        Epithelial Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for PTPRJ
        Cell adhesion Cadherin-mediated cell adhesion

    2 BioSystems Pathways for PTPRJ
        Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    PDGFR-beta signaling pathway



    1 Kegg Pathway  (Kegg details for PTPRJ):
        Adherens junction


    PTPRJ for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTPRJ: 
              Angiogenic Growth Factors in human mouse rat
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPRJ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTPRJ (Q129131, 2, 3 ENSP000004000104) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284821, 2, 3, ENSP000002158324EBI-2264500,EBI-959949 MINT-7144682 MINT-7144769 MINT-7144721 MINT-7046457 MINT-7046645 MINT-7144737 MINT-7144832 I2D: score=1 STRING: ENSP00000215832
    CTNND1O607161, 2, 3, ENSP000003820044EBI-2264500,EBI-701927 MINT-7026794 MINT-7026805 MINT-7026816 MINT-7026783 MINT-7026899 I2D: score=4 STRING: ENSP00000382004
    METP085811, 2, 3, ENSP000003172724EBI-2264500,EBI-1039152 MINT-7026855 MINT-7026878 MINT-7026889 MINT-7026866 I2D: score=3 STRING: ENSP00000317272
    PDGFRBP096191, 2, 3, ENSP000002617994EBI-2264500,EBI-641237 MINT-7026718 MINT-7026729 MINT-7026740 I2D: score=3 STRING: ENSP00000261799
    FLT1P179481, 2, ENSP000002823974EBI-2264500,EBI-1026718 MINT-7027037 MINT-7026919 STRING: ENSP00000282397
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001954positive regulation of cell-matrix adhesion ----
    GO:0006470protein dephosphorylation ----
    GO:0007507heart development IEA--
    GO:0007596blood coagulation IEA--

    PTPRJ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPRJ

    1 HMDB Compound for PTPRJ    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    5 Novoseek inferred chemical compound relationships for PTPRJ gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 69.8 66 9115287 (4), 9759839 (3), 9531590 (3), 10706446 (2) (see all 34)
    threonine 22.1 4 9115287 (2), 10706446 (1), 10914487 (1)
    serine 6.24 3 10706446 (1), 9115287 (1), 10914487 (1)
    calcium 0 2 11259588 (1), 19332538 (1)
    superoxide 0 1 10914487 (1)



    PTPRJ for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PTPRJ gene (2 alternative transcripts): 
    NM_001098503.1  NM_002843.3  

    Unigene Cluster for PTPRJ:

    Protein tyrosine phosphatase, receptor type, J
    Hs.318547  [show with all ESTs]
    Unigene Representative Sequence: NM_002843
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418331(uc010rhr.1 uc001ngp.4) ENST00000440289(uc001ngo.4)
    ENST00000534219 ENST00000527952 ENST00000526550 ENST00000527026
    miRNA
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    hsa-miR-548j hsa-miR-607 hsa-miR-199a-3p hsa-miR-106a hsa-miR-15a hsa-miR-4272 hsa-miR-519a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidPTPRJ 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): PTPRJ (NM_002843)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRJ
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPRJ
      QuantiTect SYBR Green Assays in human, mouse, rat PTPRJ
      QuantiFast Probe-based Assays in human, mouse, rat PTPRJ

    Additional mRNA sequence: 

    AK304854.1 AL359057.1 AL832403.1 BC019824.1 BC063417.1 BC068077.1 BC082273.1 BC098447.1 
    D37781.1 U10886.1 

    7 DOTS entries:

    DT.455166  DT.100745083  DT.100746679  DT.97799043  DT.410584  DT.120719220  DT.95238726 

    Selected AceView cDNA sequences (see all 132):

    BE672691 BQ682366 BU168683 AL359057 AI431759 BE857686 BC063417 CD367849 
    BM678866 AI953602 BM721862 AA367152 AA557633 BF510830 BE676666 AI953610 
    AA702982 BG031715 BU678716 BQ025594 AA903845 BM474066 AI796526 BQ929455 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPRJ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTPRJ Expression
    About this image


    PTPRJ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Testis (Reproductive System)
    PTPRJ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPRJ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.318547

    UniProtKB/Swiss-Prot: PTPRJ_HUMAN, Q12913
    Tissue specificity: Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating
    factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E.
    Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTPRJ gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptprj1 , 5 protein tyrosine phosphatase, receptor type, J1, 5 77.71(n)1
    72.7(a)1
      2 (50.19 cM)5
    192711  NM_008982.51  NP_033008.31 
     904297545 
    chicken
    (Gallus gallus)
    Aves PTPRJ1 protein tyrosine phosphatase, receptor type, J 56.22(n)
    49.79(a)
      395330  NM_204621.1  NP_989952.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTPRJ6
    protein tyrosine phosphatase, receptor type, J
    42(a)
    1 ↔ 1
    1(68208286-68313947)
    zebrafish
    (Danio rerio)
    Actinopterygii ptprja1 protein tyrosine phosphatase, receptor type, J a 49.65(n)
    39.77(a)
      559679  NM_001136242.1  NP_001129714.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ptp52F3 axon guidance protein tyrosine
    phosphatase
    38(a)   52F3   --
    worm
    (Caenorhabditis elegans)
    Secernentea F36H1.33 protein-tyrosine phosphatase 36(a)
    (best of 7)
      IV(11049774-11052625)   --


    ENSEMBL Gene Tree for PTPRJ (if available)
    TreeFam Gene Tree for PTPRJ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPRJ gene
    PTPRQ2  PTPN72  PTPRH2  PTPN52  PTPRB2  PTPRO2  PTPRR2  

    PTPRJ for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PTPRJ
    PGOHUM00000236704


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPRJ (see all 4142)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs15667341,2,,4
    C,F,O,A,HA colon cancer sample4 other148073273(-) TTGATG/TGTAGA 4 Q P mis1 ese339Minor allele frequency- N:0.00MN EA NA NS CSA WA EU 11213
    VAR_0159054
    A colon cancer sample4--see VAR_0159052 R C mis40--------
    rs1214345071,2
    Cother148073086(+) ATCTCC/TGTGTT 4 R C mis10--------
    rs71160801,2
    C,A--47681454(+) agaatT/Cgcttg 1 -- int16Minor allele frequency- C:0.00NA WA CSA 11
    rs1124850401,2
    C--47681469(+) CACAAG/AGTAGA 1 -- int12Minor allele frequency- A:0.11NA EA 122
    rs1922435851,2
    --47681631(+) AGATCG/TCAAGG 1 -- int10--------
    rs71019581,2
    C,A,H--47681677(+) aacccC/Tgtctt 1 -- int15Minor allele frequency- T:0.00NA CSA 9
    rs1854042311,2
    --47681795(+) GCAGTC/GAGCCG 1 -- int10--------
    rs1123960151,2
    C--47681851(+) GACTC-/A/AA  
            
    AAAAA
    1 -- int11CSA 2
    rs1919063691,2
    C--47681876(+) AAAAAA/GAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for PTPRJ (48002110 - 48192394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTPRJ (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv3499CNV Deletion18987735
    esv2380235CNV Deletion18987734
    esv2657950CNV Deletion23128226
    esv2674478CNV Deletion23128226
    esv2458591CNV Deletion19546169
    esv990562CNV Deletion20482838
    esv1002186CNV Deletion20482838
    esv2744445CNV Deletion23290073
    nsv428253CNV Loss18775914
    nsv317CNV Loss18451855

    Human Gene Mutation Database (HGMD): PTPRJ
    3 Site Specific Mutation Identification with PCR Assays for PTPRJ:
    Cosmic IdAA Change
    142813p.P521T
    142814p.P521L
    51623p.K1017N
    SeqTarget long-range PCR primers for resequencing PTPRJ
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPRJ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600925   
    OMIM disorders: 114500  
    Selected diseases for PTPRJ (see all 29):    
    About MalaCards
    lymphoblastic lymphoma    precursor b lymphoblastic lymphoma/leukemia    colon cancer, somatic    interstitial keratitis
    cll/sll    angiocentric glioma    hypothyroidism, autoimmune    pendred syndrome
    familial colorectal cancer    heparin-induced thrombocytopenia    keratitis    colorectal cancer
    hypothyroidism    papillary thyroid carcinoma    mantle cell lymphoma    thrombocytopenia
    thyroiditis    meningioma    b-cell lymphomas    non-hodgkin lymphoma

    1 disease from the University of Copenhagen DISEASES database for PTPRJ:
    Precursor B lymphoblastic lymphoma/leukemia

    PTPRJ for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for PTPRJ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma 40.8 4 12591742 (3), 11094075 (1)
    neoplastic transformation 34.3 4 11094075 (1), 16946481 (1)
    colon cancer 27.7 6 16682945 (2), 12776199 (1), 19672627 (1)
    adenoma 19.2 2 12776199 (1)
    tumors 15.9 17 9115287 (3), 19836242 (2), 19494114 (2), 15735685 (1) (see all 9)
    colorectal cancer 9.09 6 12776199 (3), 19672627 (1), 16258161 (1)
    cancer 9.08 12 19672627 (4), 10599888 (1), 12776199 (1), 16000320 (1) (see all 9)
    carcinoma 3.14 4 9115287 (2), 10599888 (1), 7994032 (1)

    Genetic Association Database (GAD): PTPRJ
    Human Genome Epidemiology (HuGE) Navigator: PTPRJ (9 documents)

    Export disorders for PTPRJ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPRJ gene, integrated from 10 sources (see all 98):
    (articles sorted by number of sources associating them with PTPRJ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. (PubMed id 7937872)1, 2, 3, 9 Oestman A.... Tonks N.K. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta. (PubMed id 7994032)1, 2, 3, 9 Honda H.... Hirai H. (Blood 1994)
    3. The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis. (PubMed id 15378013)1, 2, 4, 9 Iuliano R.... Fusco A. (Oncogene 2004)
    4. The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins. (PubMed id 16778204)1, 2, 9 Iervolino A.... Fusco A. (Cancer Res. 2006)
    5. Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases. (PubMed id 19494114)1, 2, 9 Sacco F.... Cesareni G. (J. Biol. Chem. 2009)
    6. An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. (PubMed id 19836242)1, 2, 9 Tarcic G.... Yarden Y. (Curr. Biol. 2009)
    7. Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. (PubMed id 19332538)1, 2, 9 Sallee J.L. and Burridge K. (J. Biol. Chem. 2009)
    8. DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients. (PubMed id 16682945)1, 2, 9 Balavenkatraman K.K.... Bohmer F.D. (Oncogene 2006)
    9. The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation. (PubMed id 14709717)1, 2, 9 Kellie S.... Jones G.E. (J. Cell Sci. 2004)
    10. CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes. (PubMed id 9531590)1, 2, 9 de la Fuente-Garcia M.A.... Gaya A. (Blood 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5795 HGNC: 9673 AceView: PTPRJ Ensembl:ENSG00000149177 euGenes: HUgn5795
    ECgene: PTPRJ Kegg: 5795 H-InvDB: PTPRJ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPRJ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPRJ Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPRJ gene:
    Search GeneIP for patents involving PTPRJ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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