PTPRJ Gene
protein-coding GIFtS: 67
GCID: GC11P047958
|
|
protein tyrosine phosphatase, receptor type, J
| |
Aliases
for PTPRJ gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Tyrosine Phosphatase, Receptor Type, J1 2 | | HPTP Eta2 3 | | DEP11 2 3 5 | | EC 3.1.3.483 8 | | CD1481 2 | | R-PTP-ETA2 | | HPTPeta1 2 | | SCC12 | | Density-Enhanced Phosphatase 12 3 | | Human Density Enhanced Phosphatase-12 | | Protein-Tyrosine Phosphatase Eta2 3 | | Protein Tyrosine Phosphatase, Receptor Type, J Polypeptide2 | | Protein-Tyrosine Phosphatase Receptor Type J2 3 | | Receptor-Type Tyrosine-Protein Phosphatase Eta2 | | DEP-12 3 | | Susceptibility To Colon Cancer 1, Mouse, Homolog Of2 | | R-PTP-J2 3 | | R-PTP-Eta1 | | CD148 Antigen2 3 | | |
Export aliases for PTPRJ gene to outside databasesPrevious GC identifers: GC11P049914 GC11P048896 GC11P048033 GC11P047966 GC11P047712 |
Summaries
for PTPRJ gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PTPRJ:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitoticcycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type IIIrepeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents areceptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cellreceptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker forActivation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-inducedsignal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. (providedby RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PTPRJ_HUMAN, Q12913Function: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB,MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in celladhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophageadhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation andthrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; throughdephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKTactivation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFRdephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulatesT-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunologicalsynapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and candephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling
Gene Wiki entry for PTPRJ
|
Genomic Views
for PTPRJ gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PTPRJ gene promoter:
TBP Spz1 Nkx5-1 PPAR-gamma1 c-Rel CP2 HOXA5 PPAR-gamma2 AP-2alphaA RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for PTPRJ
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPRJ |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2PTPRJ Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P047958: view genomic region
(about GC identifiers)
Start:
|
48,002,110 bp from pter |
End:
|
48,192,394 bp from pter |
Size:
|
190,285 bases |
Orientation:
|
plus strand |
|
Proteins
for PTPRJ gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PTPRJ_HUMAN, Q12913 (See
protein sequence)Recommended Name: Receptor-type tyrosine-protein phosphatase eta precursor Size: 1337 amino acids; 145941 Da
Subunit: Monomer. Interacts with CTNNB1 (phosphorylated) and JUP (phosphorylated). Interacts with FLT3(phosphorylated). Interacts with GAB1 and GRB2
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane (Bysimilarity). Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses
3 PDB 3D structures from  and Proteopedia  for PTPRJ:2CFV (3D)
2DLE (3D)
2NZ6 (3D)
Secondary accessions: Q15255 Q6P4H4 Q8NHM2 Q9UDA9Alternative splicing: 2 isoforms: Q12913-1 Q12913-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PTPRJ: NX_Q12913
Post-translational modifications:
N- and O-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q12913
4/6 DME Specific Peptides for PTPRJ (Q12913) (see all 6)
PTPRJ Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001091973.1 NP_002834.3
ENSEMBL proteins: ENSP00000400010 ENSP00000409733 ENSP00000432686 ENSP00000435618
Human Recombinant Protein Products for PTPRJ:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
PTPRJ for ontologies About GeneDecksing
PTPRJ Antibody Products:
Assay Products for PTPRJ: |
Protein
Domains /
Families
for PTPRJ gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PTPRJ for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q12913ProtoNet protein and cluster: Q12913 1 Blocks protein family: IPB000242 Protein tyrosine phosphatase signature
UniProtKB/Swiss-Prot: PTPRJ_HUMAN, Q12913Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamilySimilarity: Contains 9 fibronectin type-III domainsSimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function
for PTPRJ gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PTPRJ_HUMAN, Q12913Function: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB,MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in celladhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophageadhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation andthrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; throughdephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKTactivation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFRdephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulatesT-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunologicalsynapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and candephosphorylate PLCG1 and LAT to down-regulate prolongation of signalingCatalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate Genatlas biochemistry entry for PTPRJ:protein tyrosine kinase,receptor type,J polypeptide
Enzyme Number (IUBMB): EC 3.1.3.481 2
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
PTPRJ for ontologies About GeneDecksing
Phenotypes:
5 GenomeRNAi human phenotypes for PTPRJ:
15/16 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Ptprj) (see all 16):
PTPRJ for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for PTPRJ: Ptprjtm1Fus Ptprjtm1Taka Ptprjtm1.2Weis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRJ (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRJ (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PTPRJ (NM_002843) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTPRJ | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRJ |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRJ |
|
Pathways & Interactions
for PTPRJ gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeleton remodeling Slit-Robo signaling | | | 2 | Adherens junction | | | 3 | PDGFR-beta signaling pathway | | | 4 | PAK Pathway | | | 5 | Development HGF signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for PTPRJ
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPRJ
1  GeneGo (Thomson Reuters) Pathway for PTPRJ
2  BioSystems Pathways for PTPRJ
1 
Kegg Pathway (Kegg details for PTPRJ):
PTPRJ for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPRJ
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/60 Interacting proteins for PTPRJ (Q129131, 2, 3 ENSP000004000104) via UniProtKB, MINT, STRING, and/or I2D (see all 60)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| MAPK1 | P284822, 3, ENSP000002158324 | MINT-7144682 MINT-7144769 MINT-7144721 MINT-7046457 MINT-7046645 MINT-7144737 MINT-7144832 I2D:
score=1 STRING: ENSP00000215832 | | CTNND1 | O607162, 3, ENSP000003820044 | MINT-7026794 MINT-7026805 MINT-7026816 MINT-7026783 MINT-7026899 I2D:
score=4 STRING: ENSP00000382004 | | MET | P085812, 3, ENSP000003172724 | MINT-7026855 MINT-7026878 MINT-7026889 MINT-7026866 I2D:
score=3 STRING: ENSP00000317272 | | PDGFRB | P096192, 3, ENSP000002617994 | MINT-7026718 MINT-7026729 MINT-7026740 I2D:
score=3 STRING: ENSP00000261799 | | JUP | P149232, 3, ENSP000003111134 | MINT-7026835 I2D:
score=2 STRING: ENSP00000311113 |
About this table
Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table
PTPRJ for ontologies About GeneDecksing
|
Drugs & Compounds
for PTPRJ gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PTPRJ for compounds About GeneDecksing
 Browse Tocris compounds for PTPRJ
1 HMDB Compound for PTPRJ About this table
5 Novoseek chemical compound relationships for PTPRJ gene About this table
Search CenterWatch for drugs/clinical trials and news about PTPRJ
|
Transcripts
for PTPRJ gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PTPRJ gene (2 alternative transcripts): NM_001098503.1 NM_002843.3 Unigene Cluster for PTPRJ: Protein tyrosine phosphatase, receptor type, J Hs.318547 [show with all ESTs]Unigene Representative Sequence: NM_0028436 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000418331(uc010rhr.1 uc001ngp.4) ENST00000440289(uc001ngo.4)
ENST00000534219 ENST00000527952 ENST00000526550 ENST00000527026
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRJ (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRJ (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PTPRJ (NM_002843) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTPRJ | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRJ |
Additional cDNA sequence: AK304854.1 AL359057.1 AL832403.1 BC019824.1 BC063417.1 BC068077.1 BC082273.1 BC098447.1 D37781.1 U10886.1 7 DOTS entries: DT.455166 DT.100745083 DT.100746679 DT.97799043 DT.410584 DT.120719220 DT.95238726 24/132 AceView cDNA sequences (see all 132): BC063417 BM678866 CD367849 AI953602 AA367152 BM721862 BE857686 BQ682366 BU168683 AL359057 BE672691 AI431759 BX090340 AI394481 AI684380 BQ184085 BM720294 BU195364 CA435793 BU624135 AI494540 BU740051 AI361756 BM853625
GeneLoc Exon Structure
|
Expression
for PTPRJ gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PTPRJ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PTPRJ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTPRJ
SOURCE GeneReport for Unigene cluster: Hs.318547
UniProtKB/Swiss-Prot: PTPRJ_HUMAN, Q12913Tissue specificity: Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulatingfactor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E.Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density
SABiosciences Expression via Pathway-Focused PCR Arrays including PTPRJ:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPRJ
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTPRJ | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPRJ | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPRJ | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRJ |
Orthologs
for PTPRJ gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PTPRJ gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PTPRJ1 |
protein tyrosine phosphatase, receptor type, J |
55.59(n)
48.4(a) |
|
395330 NM_204621.1 NP_989952.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PTPRM6PTPRJ6 |
-- |
7(a)44(a) |
possible ortholog1 ↔ 1 |
GL343431.1(597378-762722) 1(68273228-68313947) |
zebrafish
(Danio rerio) |
Actinopterygii |
ptprja1 |
protein tyrosine phosphatase, receptor type, J a |
46.76(n)
34.69(a) |
|
559679 NM_001136242.1 NP_001129714.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ptp52F3 |
axon guidance protein tyrosine phosphatase |
38(a) |
|
52F3 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
F36H1.33 |
protein-tyrosine phosphatase |
36(a)
(best of 7) |
|
IV(11049774-11052625) -- |
ENSEMBL Gene Tree for PTPRJ (if available)
TreeFam Gene Tree for PTPRJ (if available) |
Paralogs
for PTPRJ gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PTPRJ gene
- PTPN72 PTPRH2 PTPN222 PTPRO2 PTPN112 PTPN62 PTPRQ2 PTPN182
- PTPN122 PTPN52 PTPRB2 PTPRR2
PTPRJ for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PTPRJ
PGOHUM00000236704
|
Genomic Variants
for PTPRJ gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PTPRJ (48002110 - 48192394 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for PTPRJ
1 CNV: 101212
5 Indels: 44904 42529 11557 39835 61133
Human Gene Mutation Database (HGMD): PTPRJ
| 3 SABiosciences Cancer Mutation PCR Assays for PTPRJ: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPRJ |
|
Disorders
/ Diseases
for PTPRJ gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PTPRJ for disorders About GeneDecksing
OMIM gene information: 600925
OMIM disorders: 114500
20/23  diseases for PTPRJ (see all 23): About MalaCardscll/sll colon cancer precursor b lymphoblastic lymphoma/leukemia colon cancer, somatic
interstitial keratitis b-cell lymphomas pendred syndrome hypothyroidism, autoimmune
papillary thyroid carcinoma thyroid carcinoma hypothyroidism familial colorectal cancer
colorectal cancer keratitis thyroiditis carcinoma
thrombosis colon carcinoma pancreatic carcinoma meningioma
2 diseases from the University of Copenhagen DISEASES database for PTPRJ:Precursor B lymphoblastic lymphoma/leukemia CD45 deficiency 8 Novoseek disease relationships for PTPRJ gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| thyroid carcinoma |
40.8 |
4 |
12591742 (3), 11094075 (1) |
| neoplastic transformation |
34.3 |
4 |
11094075 (1), 16946481 (1) |
| colon cancer |
27.7 |
6 |
16682945 (2), 12776199 (1), 19672627 (1) |
| adenoma |
19.2 |
2 |
12776199 (1) |
| tumors |
15.9 |
17 |
9115287 (3), 19836242 (2), 19494114 (2), 15735685 (1) (see all 9) |
| colorectal cancer |
9.09 |
6 |
12776199 (3), 19672627 (1), 16258161 (1) |
| cancer |
9.08 |
12 |
19672627 (4), 10599888 (1), 12776199 (1), 16000320 (1) (see all 9) |
| carcinoma |
3.14 |
4 |
9115287 (2), 10599888 (1), 7994032 (1) |
Genetic Association Database (GAD): PTPRJ
Human Genome Epidemiology (HuGE) Navigator: PTPRJ (9 documents)
Export disorders for PTPRJ gene to outside databases
|
Publications
for PTPRJ gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PTPRJ gene, integrated from 9 sources (see all 87):
(articles sorted by number of sources associating them with PTPRJ) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. (PubMed id 7937872)1, 2, 3, 9 Oestman A.... Tonks N.K. (1994)
- Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta. (PubMed id 7994032)1, 2, 3, 9 Honda H.... Hirai H. (1994)
- The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis. (PubMed id 15378013)1, 2, 4, 9 Iuliano R....Fusco A. (2004)
- The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins. (PubMed id 16778204)1, 2, 9 Iervolino A....Fusco A. (2006)
- Tumor suppressor density-enhanced phosphatase-1 (DEP- 1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases. (PubMed id 19494114)1, 2, 9 Sacco F....Cesareni G. (2009)
- An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. (PubMed id 19836242)1, 2, 9 Tarcic G....Yarden Y. (2009)
- Density-enhanced Phosphatase 1 Regulates Phosphorylation of Tight Junction Proteins and Enhances Barrier Function of Epithelial Cells. (PubMed id 19332538)1, 2, 9 Sallee J.L. and Burridge K. (2009)
- DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients. (PubMed id 16682945)1, 2, 9 Balavenkatraman K.K....Bohmer F.D. (2006)
- The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation. (PubMed id 14709717)1, 2, 9 Kellie S....Jones G.E. (2004)
- CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes. (PubMed id 9531590)1, 2, 9 de la Fuente-Garcia M.A....Gaya A. (1998)
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External Searches for PTPRJ gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PTPRJ gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PTPRJ gene
(According to HUGE)
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Specialized Databases showing PTPRJ gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for PTPRJ gene:
Search GeneIP for patents involving PTPRJ
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PTPRJ gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PTPRJ | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPRJ | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPRJ | | | OriGene Protein Over-expression Lysate for PTPRJ | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PTPRJ | | OriGene 3'-UTR Clone for PTPRJ | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRJ | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRJ | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PTPRJ | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTPRJ | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPRJ | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPRJ | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPRJ | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPRJ | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPRJ |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRJ |
|  |  |  |  | | | | ThermoFisher Antibodies for PTPRJ |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRJ |
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