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Aliases for PTPRH Gene

Aliases for PTPRH Gene

  • Protein Tyrosine Phosphatase, Receptor Type, H 2 3
  • Stomach Cancer-Associated Protein Tyrosine Phosphatase 1 3 4
  • Transmembrane-Type Protein-Tyrosine Phosphatase Type H 3 4
  • EC 3.1.3.48 4 63
  • R-PTP-H 3 4
  • SAP1 3 4
  • Receptor-Type Tyrosine-Protein Phosphatase H 3
  • SAP-1 4

External Ids for PTPRH Gene

Summaries for PTPRH Gene

Entrez Gene Summary for PTPRH Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

GeneCards Summary for PTPRH Gene

PTPRH (Protein Tyrosine Phosphatase, Receptor Type, H) is a Protein Coding gene. Diseases associated with PTPRH include stomach cancer. Among its related pathways are PAK Pathway. GO annotations related to this gene include transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRO.

UniProtKB/Swiss-Prot for PTPRH Gene

  • May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells.

Gene Wiki entry for PTPRH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRH Gene

Genomics for PTPRH Gene

Genomic Location for PTPRH Gene

Start:
55,181,247 bp from pter
End:
55,209,506 bp from pter
Size:
28,260 bases
Orientation:
Minus strand

Genomic View for PTPRH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRH Gene

Regulatory Elements for PTPRH Gene

Proteins for PTPRH Gene

  • Protein details for PTPRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD43-PTPRH_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase H
    Protein Accession:
    Q9HD43
    Secondary Accessions:
    • C9JCH2
    • Q15426
    • Q2NKN9
    • Q2NKP0

    Protein attributes for PTPRH Gene

    Size:
    1115 amino acids
    Molecular mass:
    122352 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (Probable). Interacts with LCK.
    SequenceCaution:
    • Sequence=BAA03645.2; Type=Frameshift; Positions=213, 244, 264, 287, 291; Evidence={ECO:0000305};

    Alternative splice isoforms for PTPRH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRH Gene

Proteomics data for PTPRH Gene at MOPED

Selected DME Specific Peptides for PTPRH Gene

Post-translational modifications for PTPRH Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn35, Asn83, Asn107, Asn172, Asn256, Asn285, Asn350, Asn434, Asn468, Asn556, Asn620, and Asn642

Other Protein References for PTPRH Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PTPRH Gene

Gene Families for PTPRH Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • PTPR :Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like
IUPHAR :

Suggested Antigen Peptide Sequences for PTPRH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HD43

UniProtKB/Swiss-Prot:

PTPRH_HUMAN
Domain:
  • The extracellular domain mediates homodimerization. One or more cysteines in the extracellular domain is essential for the formation of dimers probably by forming a disulfide bond:
    • Q9HD43
  • The cytoplasmic domain mediates the interaction with LCK:
    • Q9HD43
  • Contains 8 fibronectin type-III domains.:
    • Q9HD43
  • Contains 1 tyrosine-protein phosphatase domain.:
    • Q9HD43
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.:
    • Q9HD43
genes like me logo Genes that share domains with PTPRH: view

Function for PTPRH Gene

Molecular function for PTPRH Gene

GENATLAS Biochemistry: protein tyrosine phosphatase,receptor type III,eta polypeptide
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Regulated by reversible dimerization. Dimerization reduces its catalytic activity.
UniProtKB/Swiss-Prot Function: May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells.
UniProtKB/Swiss-Prot Induction: Induced at the early stage of hepatocellular carcinoma and is suppressed at later stages.

Enzyme Numbers (IUBMB) for PTPRH Gene

Gene Ontology (GO) - Molecular Function for PTPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity --
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 12907755
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPRH: view
genes like me logo Genes that share phenotypes with PTPRH: view

Animal Models for PTPRH Gene

MGI Knock Outs for PTPRH:

miRNA for PTPRH Gene

miRTarBase miRNAs that target PTPRH

No data available for Transcription Factor Targeting and HOMER Transcription for PTPRH Gene

Localization for PTPRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRH Gene

Membrane; Single-pass type I membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRH Gene COMPARTMENTS Subcellular localization image for PTPRH gene
Compartment Confidence
mitochondrion 4
nucleus 4
plasma membrane 4
cytosol 3
endoplasmic reticulum 1
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005887 integral component of plasma membrane TAS 8294459
genes like me logo Genes that share ontologies with PTPRH: view

Pathways for PTPRH Gene

SuperPathways for PTPRH Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPRH: view

Pathways by source for PTPRH Gene

1 Qiagen pathway for PTPRH Gene

Gene Ontology (GO) - Biological Process for PTPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 8294459
GO:0006915 apoptotic process IEA --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 8294459
genes like me logo Genes that share ontologies with PTPRH: view

Compounds for PTPRH Gene

(2) HMDB Compounds for PTPRH Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(1) Novoseek inferred chemical compound relationships for PTPRH Gene

Compound -log(P) Hits PubMed IDs
tyrosine 43.4 5
genes like me logo Genes that share compounds with PTPRH: view

Transcripts for PTPRH Gene

Unigene Clusters for PTPRH Gene

Protein tyrosine phosphatase, receptor type, H:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRH Gene

No ASD Table

Relevant External Links for PTPRH Gene

GeneLoc Exon Structure for
PTPRH
ECgene alternative splicing isoforms for
PTPRH

Expression for PTPRH Gene

mRNA expression in normal human tissues for PTPRH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRH Gene

This gene is overexpressed in Colon - Transverse (8.1), Small Intestine - Terminal Ileum (7.1), Spleen (6.4), Liver (4.9), Adrenal Gland (4.9), and Stomach (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTPRH Gene

SOURCE GeneReport for Unigene cluster for PTPRH Gene Hs.179770

mRNA Expression by UniProt/SwissProt for PTPRH Gene

Q9HD43-PTPRH_HUMAN
Tissue specificity: Expressed at high levels in the brain, spleen and liver and at lower levels in the heart and stomach. Expressed in pancreatic and colorectal cancer cells, but not in normal pancreas or colon. Expression in hepatocellular carcinoma is related to the differentiation status of the tumor and expression is inversely related to tumor aggressiveness.
genes like me logo Genes that share expressions with PTPRH: view

Orthologs for PTPRH Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRH 35
  • 97.76 (n)
  • 95.91 (a)
PTPRH 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRH 35
  • 75.69 (n)
  • 67.15 (a)
PTPRH 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRH 35
  • 73.17 (n)
  • 64.25 (a)
PTPRH 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprh 35
  • 70.77 (n)
  • 59.85 (a)
Ptprh 16
Ptprh 36
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPRH 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRH 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprh 35
  • 70.12 (n)
  • 57.54 (a)
chicken
(Gallus gallus)
Aves PTPRH 36
  • 16 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRH 36
  • 15 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprh 35
  • 47.36 (n)
  • 35.97 (a)
zebrafish
(Danio rerio)
Actinopterygii ptprh 35
  • 45.35 (n)
  • 32.74 (a)
ptprh 36
  • 29 (a)
OneToMany
ptprh 36
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.31 36
  • 31 (a)
OneToMany
T27A3.5 37
  • 30 (a)
C17H12.3 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 10 (a)
ManyToMany
Species with no ortholog for PTPRH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRH Gene

ENSEMBL:
Gene Tree for PTPRH (if available)
TreeFam:
Gene Tree for PTPRH (if available)

Paralogs for PTPRH Gene

Paralogs for PTPRH Gene

genes like me logo Genes that share paralogs with PTPRH: view

Variants for PTPRH Gene

Sequence variations from dbSNP and Humsavar for PTPRH Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs876515 -- 55,209,873(+) CCCTC(A/G)TCCCT upstream-variant-2KB
rs890870 - 55,188,086(-) CAGAC(A/G)AGTAC missense, reference
rs1136578 -- 55,186,521(-) GTGCC(C/T)CTGAA reference, synonymous-codon
rs2042907 -- 55,200,535(-) ATCTC(C/T)GACAA intron-variant
rs2288515 - 55,202,167(-) CAGCA(C/T)ACACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PTPRH Gene

Variant ID Type Subtype PubMed ID
esv2668035 CNV Deletion 23128226
esv2718960 CNV Deletion 23290073
nsv512598 CNV Loss 21212237
esv1564792 CNV Deletion 17803354

Relevant External Links for PTPRH Gene

HapMap Linkage Disequilibrium report
PTPRH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRH Gene

Disorders for PTPRH Gene

(1) MalaCards Diseases for PTPRH Gene

Search for PTPRH Gene in MalaCards »

(1) University of Copenhagen DISEASES for PTPRH Gene

(1) Novoseek inferred disease relationships for PTPRH Gene

Disease -log(P) Hits PubMed IDs
cancer 0 2

Relevant External Links for PTPRH

Human Genome Epidemiology (HuGE) Navigator
PTPRH
Tumor Gene Database (TGDB):
PTPRH
genes like me logo Genes that share disorders with PTPRH: view

No data available for UniProtKB/Swiss-Prot for PTPRH Gene

Publications for PTPRH Gene

  1. Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers. (PMID: 8294459) Matozaki T. … Kasuga M. (J. Biol. Chem. 1994) 2 3 4 23
  2. Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas. (PMID: 11278335) Noguchi T. … Kasuga M. (J. Biol. Chem. 2001) 3 4 23
  3. Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1. (PMID: 12101188) Takada T. … Kasuga M. (J. Biol. Chem. 2002) 3 4 23
  4. Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function. (PMID: 12837766) Ito T. … Matozaki T. (J. Biol. Chem. 2003) 3 4 23
  5. Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma. (PMID: 12879010) Nagano H. … Hayashi Y. (Oncogene 2003) 3 4 23

Products for PTPRH Gene

Sources for PTPRH Gene

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