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Aliases for PTPRG Gene

Aliases for PTPRG Gene

  • Protein Tyrosine Phosphatase, Receptor Type G 2 3 5
  • R-PTP-GAMMA 3 4
  • EC 3.1.3.48 4 61
  • PTPG 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, Gamma Polypeptide 3
  • Receptor Type Protein Tyrosine Phosphatase Gamma 3
  • Receptor-Type Tyrosine-Protein Phosphatase Gamma 3
  • Receptor-Type Protein Phosphatase Gamma 3
  • Receptor Tyrosine Phosphatase Gamma 3
  • Protein Tyrosine Phosphatase Gamma 3
  • Protein-Tyrosine Phosphatase Gamma 4
  • H_RG317H01.1 3
  • HPTPG 3
  • RPTPG 3

External Ids for PTPRG Gene

Previous HGNC Symbols for PTPRG Gene

  • PTPG

Previous GeneCards Identifiers for PTPRG Gene

  • GC03P060412
  • GC03P060949
  • GC03P061402
  • GC03P061504

Summaries for PTPRG Gene

Entrez Gene Summary for PTPRG Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRG Gene

PTPRG (Protein Tyrosine Phosphatase, Receptor Type G) is a Protein Coding gene. Diseases associated with PTPRG include Infantile Myofibromatosis and Corneal Fleck Dystrophy. Among its related pathways are PAK Pathway. GO annotations related to this gene include identical protein binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRZ1.

UniProtKB/Swiss-Prot for PTPRG Gene

  • Possesses tyrosine phosphatase activity.

Gene Wiki entry for PTPRG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRG Gene

Genomics for PTPRG Gene

Regulatory Elements for PTPRG Gene

Enhancers for PTPRG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F061521 0.7 FANTOM5 11.4 -40.1 -40097 0.2 TBP PKNOX1 MTA2 NFYA JUNB TBX21 EP300 RELA RFX5 JUND PTPRG GC03P061488
GH03F061589 0.6 ENCODE 12 +28.3 28280 0.6 HDGF JUND ZNF692 ZSCAN16 NFE2 MAFK NFE2L2 PTPRG GC03P061682
GH03F061612 0.6 Ensembl 10.8 +50.8 50832 0.4 PKNOX1 ATF3 TEAD4 ZBTB33 RAD21 NR2F2 YY1 PTPRG GC03P061682
GH03F061842 0.6 FANTOM5 3.7 +281.4 281430 0.4 GLIS1 CEBPG ZBTB40 ZNF18 PTPRG GC03P061757 GC03P062066
GH03F061558 1.1 ENCODE 0.8 +0.6 554 6.3 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF548 PTPRG GC03P061682
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTPRG on UCSC Golden Path with GeneCards custom track

Promoters for PTPRG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001365737 931 5401 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF548

Genomic Location for PTPRG Gene

Chromosome:
3
Start:
61,561,569 bp from pter
End:
62,297,613 bp from pter
Size:
736,045 bases
Orientation:
Plus strand

Genomic View for PTPRG Gene

Genes around PTPRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRG Gene

Proteins for PTPRG Gene

  • Protein details for PTPRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23470-PTPRG_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase gamma
    Protein Accession:
    P23470
    Secondary Accessions:
    • B2RU12
    • B7ZLX5
    • Q15623
    • Q59EE0
    • Q68DU5

    Protein attributes for PTPRG Gene

    Size:
    1445 amino acids
    Molecular mass:
    162003 Da
    Quaternary structure:
    • Monomer; active form. Homodimer; inactive form (Probable). Interacts with CNTN3, CNTN4, CNTN5 and CNTN6.
    SequenceCaution:
    • Sequence=BAD93108.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRG Gene

    Alternative splice isoforms for PTPRG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRG Gene

Selected DME Specific Peptides for PTPRG Gene

P23470:
  • LPVLTFVR
  • YIVIDSML
  • HYTQWPD
  • VQTEEQY
  • YIATQGP
  • VHCSAGVGRTG
  • DYINANY
  • QVAKMINLMRPGVF
  • GTDYINASYIMGYY
  • QTEEQYIFIHDA
  • KDFWRMIWDHNAQ
  • GFLKHIR
  • KCDQYWP
  • AEDEFVYWP
  • DFILEATQDDYVLEVRHFQCPKWPNPD
  • DSMLQQI

Post-translational modifications for PTPRG Gene

  • Glycosylation at Asn 109, Asn 113, Asn 156, Asn 359, Asn 444, Asn 619, Asn 631, Thr 640, Thr 715, and Asn 722
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPRG Gene

Antibody Products

  • R&D Systems Antibodies for PTPRG (PTP gamma/PTPRG)
  • Cloud-Clone Corp. Antibodies for PTPRG

Domains & Families for PTPRG Gene

Graphical View of Domain Structure for InterPro Entry

P23470

UniProtKB/Swiss-Prot:

PTPRG_HUMAN :
  • Contains 1 alpha-carbonic anhydrase domain.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
Domain:
  • Contains 1 alpha-carbonic anhydrase domain.
  • Contains 1 fibronectin type-III domain.
  • Contains 2 tyrosine-protein phosphatase domains.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
genes like me logo Genes that share domains with PTPRG: view

Function for PTPRG Gene

Molecular function for PTPRG Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type,gamma polypeptide,deleted in benign proliferative breast disease,associated with familial breast cancer
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Possesses tyrosine phosphatase activity.

Enzyme Numbers (IUBMB) for PTPRG Gene

Gene Ontology (GO) - Molecular Function for PTPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA,IDA 19167335
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 8382771
GO:0005515 protein binding IPI 19167335
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTPRG: view
genes like me logo Genes that share phenotypes with PTPRG: view

Animal Models for PTPRG Gene

MGI Knock Outs for PTPRG:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPRG

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRG Gene

Localization for PTPRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRG gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PTPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005887 integral component of plasma membrane TAS 8382771
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PTPRG: view

Pathways & Interactions for PTPRG Gene

SuperPathways for PTPRG Gene

SuperPathway Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPRG: view

Pathways by source for PTPRG Gene

1 Qiagen pathway for PTPRG Gene

Gene Ontology (GO) - Biological Process for PTPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 8382771
GO:0007420 brain development IEA --
GO:0010633 negative regulation of epithelial cell migration IMP 21724833
GO:0010977 negative regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with PTPRG: view

No data available for SIGNOR curated interactions for PTPRG Gene

Drugs & Compounds for PTPRG Gene

(4) Drugs for PTPRG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PTPRG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PTPRG: view

Transcripts for PTPRG Gene

Unigene Clusters for PTPRG Gene

Protein tyrosine phosphatase, receptor type, G:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRG Gene

No ASD Table

Relevant External Links for PTPRG Gene

GeneLoc Exon Structure for
PTPRG
ECgene alternative splicing isoforms for
PTPRG

Expression for PTPRG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPRG Gene

Protein differential expression in normal tissues from HIPED for PTPRG Gene

This gene is overexpressed in Serum (38.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTPRG Gene



NURSA nuclear receptor signaling pathways regulating expression of PTPRG Gene:

PTPRG

SOURCE GeneReport for Unigene cluster for PTPRG Gene:

Hs.595541

mRNA Expression by UniProt/SwissProt for PTPRG Gene:

P23470-PTPRG_HUMAN
Tissue specificity: Found in a variety of tissues.
genes like me logo Genes that share expression patterns with PTPRG: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PTPRG Gene

Orthologs for PTPRG Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRG 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia PTPRG 34 35
  • 92.56 (n)
oppossum
(Monodelphis domestica)
Mammalia PTPRG 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRG 34 35
  • 90.93 (n)
rat
(Rattus norvegicus)
Mammalia Ptprg 34
  • 89.89 (n)
mouse
(Mus musculus)
Mammalia Ptprg 34 16 35
  • 89.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRG 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRG 34 35
  • 81.59 (n)
lizard
(Anolis carolinensis)
Reptilia PTPRG 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprg 34
  • 75.13 (n)
zebrafish
(Danio rerio)
Actinopterygii ptprga 34 35
  • 69.87 (n)
ca16b 35
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ptp99A 36 35
  • 46 (a)
CG6906 36
  • 35 (a)
Ptp69D 36
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK616.7 36
  • 37 (a)
M04G7.2 36
  • 36 (a)
C17H12.3 36
  • 34 (a)
F47B3.7 36
  • 33 (a)
K04D7.4 36
  • 32 (a)
K07F5.8 36
  • 32 (a)
ZK484.7 36
  • 32 (a)
C55B7.3 36
  • 31 (a)
T27A3.5 36
  • 31 (a)
F47B3.1 36
  • 30 (a)
F47B3.6 36
  • 30 (a)
F10G8.1 36
  • 28 (a)
Species where no ortholog for PTPRG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRG Gene

ENSEMBL:
Gene Tree for PTPRG (if available)
TreeFam:
Gene Tree for PTPRG (if available)

Paralogs for PTPRG Gene

Variants for PTPRG Gene

Sequence variations from dbSNP and Humsavar for PTPRG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1006588 -- 61,955,182(+) ATTCT(A/G)TTCTG intron-variant
rs1007554 -- 62,213,929(-) ggtgt(G/T)agcca intron-variant, nc-transcript-variant
rs1007555 -- 62,213,797(-) GTGGC(A/C)CTGAG intron-variant, nc-transcript-variant
rs1007826 -- 62,121,635(+) GGTTA(C/G)TGTCA intron-variant
rs1007827 -- 62,121,822(+) GGAGA(A/G)AGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRG Gene

Variant ID Type Subtype PubMed ID
nsv1127964 CNV deletion 24896259
nsv1131705 CNV deletion 24896259
nsv1133321 CNV tandem duplication 24896259
nsv1148938 CNV deletion 26484159
nsv236686 CNV deletion 16902084
nsv437862 CNV loss 16468122
nsv460575 CNV gain 19166990
nsv471782 CNV loss 16327809
nsv471908 CNV novel sequence insertion 20440878
nsv478900 CNV novel sequence insertion 20440878
nsv516255 CNV loss 19592680
nsv517920 CNV loss 19592680
nsv522606 CNV loss 19592680
nsv523876 CNV loss 19592680
nsv590438 CNV loss 21841781
nsv590439 CNV loss 21841781
nsv590440 CNV gain 21841781
nsv590441 CNV loss 21841781
nsv822105 CNV gain 20364138
nsv822106 CNV gain 20364138
nsv834711 CNV loss 17160897
nsv834712 CNV gain 17160897
nsv979838 CNV duplication 23825009
nsv1123658 CNV deletion 24896259
nsv1114384 CNV deletion 24896259
nsv1072695 CNV deletion 25765185
nsv1072694 CNV deletion 25765185
nsv1013884 CNV loss 25217958
nsv1012600 CNV gain 25217958
nsv1009361 CNV loss 25217958
nsv1008615 CNV gain 25217958
nsv1000965 CNV gain 25217958
esv3893713 CNV loss 25118596
esv3596369 CNV loss 21293372
esv3596368 CNV loss 21293372
esv3596365 CNV loss 21293372
esv3596363 CNV loss 21293372
esv3596362 CNV gain 21293372
esv3596361 CNV loss 21293372
esv3596358 CNV loss 21293372
esv3596357 CNV loss 21293372
esv3596354 CNV gain 21293372
esv3596352 CNV loss 21293372
esv3596349 CNV loss 21293372
esv3596347 CNV loss 21293372
esv3568812 CNV loss 25503493
esv3568811 CNV loss 25503493
esv3568810 CNV loss 25503493
esv3568808 CNV loss 25503493
esv3568804 CNV loss 25503493
esv3561976 CNV deletion 23714750
esv3561968 CNV deletion 23714750
esv35004 CNV gain 17911159
esv3407063 CNV insertion 20981092
esv3384448 CNV insertion 20981092
esv3302772 CNV tandem duplication 20981092
esv2759153 CNV gain 17122850
esv2725338 CNV deletion 23290073
esv2725337 CNV deletion 23290073
esv2725336 CNV deletion 23290073
esv2725335 CNV deletion 23290073
esv2725334 CNV deletion 23290073
esv2673237 CNV deletion 23128226
esv2672277 CNV deletion 23128226
esv2667638 CNV deletion 23128226
esv2658385 CNV deletion 23128226
esv2599998 CNV deletion 19546169
esv2554644 CNV deletion 19546169
esv2548031 CNV insertion 19546169
esv2386760 CNV deletion 18987734
esv23804 CNV loss 19812545
esv22782 CNV loss 19812545
esv2223333 CNV deletion 18987734
esv1631216 CNV deletion 17803354
esv1217921 CNV deletion 17803354
esv1005605 CNV deletion 20482838
esv1001407 CNV deletion 20482838
dgv897e214 CNV loss 21293372
dgv896e214 CNV gain 21293372
dgv895e214 CNV gain 21293372
dgv4755n100 CNV gain 25217958
dgv1382e212 CNV loss 25503493
dgv1381e212 CNV loss 25503493

Variation tolerance for PTPRG Gene

Residual Variation Intolerance Score: 5.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRG Gene

Human Gene Mutation Database (HGMD)
PTPRG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPRG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRG Gene

Disorders for PTPRG Gene

MalaCards: The human disease database

(5) MalaCards diseases for PTPRG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
infantile myofibromatosis
  • myofibromatosis
corneal fleck dystrophy
  • corneal dystrophy, fleck
familial breast cancer
  • breast cancer, familial
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
fuchs' endothelial dystrophy
  • fced
- elite association - COSMIC cancer census association via MalaCards
Search PTPRG in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPRG

Genetic Association Database (GAD)
PTPRG
Human Genome Epidemiology (HuGE) Navigator
PTPRG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRG
genes like me logo Genes that share disorders with PTPRG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRG Gene

Publications for PTPRG Gene

  1. Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation. (PMID: 8833149) Kastury K. … Huebner K. (Genomics 1996) 3 4 22 64
  2. Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21. (PMID: 1711217) LaForgia S. … Weston A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 22 64
  3. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J. … Levinson D.F. (Mol. Psychiatry 2011) 3 46 64
  4. Genome-wide association study identifies five new schizophrenia loci. (PMID: 21926974) (Nat. Genet. 2011) 3 46 64
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 46 64

Products for PTPRG Gene

Sources for PTPRG Gene

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