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Aliases for PTPRG Gene

Aliases for PTPRG Gene

  • Protein Tyrosine Phosphatase, Receptor Type G 2 3
  • Protein Tyrosine Phosphatase, Receptor Type, G 3 5
  • Protein-Tyrosine Phosphatase Gamma 3 4
  • R-PTP-GAMMA 3 4
  • EC 3.1.3.48 4 63
  • PTPG 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, Gamma Polypeptide 3
  • Receptor Type Protein Tyrosine Phosphatase Gamma 3
  • Receptor-Type Protein Phosphatase Gamma 3
  • Receptor Tyrosine Phosphatase Gamma 3
  • Protein Tyrosine Phosphatase Gamma 3
  • H_RG317H01.1 3
  • HPTPG 3
  • RPTPG 3

External Ids for PTPRG Gene

Previous HGNC Symbols for PTPRG Gene

  • PTPG

Previous GeneCards Identifiers for PTPRG Gene

  • GC03P060412
  • GC03P060949
  • GC03P061402
  • GC03P061504

Summaries for PTPRG Gene

Entrez Gene Summary for PTPRG Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRG Gene

PTPRG (Protein Tyrosine Phosphatase, Receptor Type G) is a Protein Coding gene. Diseases associated with PTPRG include infantile myofibromatosis and corneal fleck dystrophy. Among its related pathways are PAK Pathway. GO annotations related to this gene include identical protein binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRK.

UniProtKB/Swiss-Prot for PTPRG Gene

  • Possesses tyrosine phosphatase activity.

Gene Wiki entry for PTPRG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRG Gene

Genomics for PTPRG Gene

Regulatory Elements for PTPRG Gene

Promoters for PTPRG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTPRG on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPRG Gene

Chromosome:
3
Start:
61,561,569 bp from pter
End:
62,297,613 bp from pter
Size:
736,045 bases
Orientation:
Plus strand

Genomic View for PTPRG Gene

Genes around PTPRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRG Gene

Proteins for PTPRG Gene

  • Protein details for PTPRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23470-PTPRG_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase gamma
    Protein Accession:
    P23470
    Secondary Accessions:
    • B2RU12
    • B7ZLX5
    • Q15623
    • Q59EE0
    • Q68DU5

    Protein attributes for PTPRG Gene

    Size:
    1445 amino acids
    Molecular mass:
    162003 Da
    Quaternary structure:
    • Monomer; active form. Homodimer; inactive form (Probable). Interacts with CNTN3, CNTN4, CNTN5 and CNTN6.
    SequenceCaution:
    • Sequence=BAD93108.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRG Gene

    Alternative splice isoforms for PTPRG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRG Gene

Proteomics data for PTPRG Gene at MOPED

Post-translational modifications for PTPRG Gene

  • Glycosylation at Asn 109, Asn 113, Asn 156, Asn 359, Asn 444, Asn 619, Asn 631, Thr 640, Thr 715, and Asn 722
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPRG Gene

Antibody Products

  • R&D Systems Antibodies for PTPRG (PTP gamma/PTPRG)

Domains & Families for PTPRG Gene

Graphical View of Domain Structure for InterPro Entry

P23470

UniProtKB/Swiss-Prot:

PTPRG_HUMAN :
  • Contains 1 alpha-carbonic anhydrase domain.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
Domain:
  • Contains 1 alpha-carbonic anhydrase domain.
  • Contains 1 fibronectin type-III domain.
  • Contains 2 tyrosine-protein phosphatase domains.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
genes like me logo Genes that share domains with PTPRG: view

Function for PTPRG Gene

Molecular function for PTPRG Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type,gamma polypeptide,deleted in benign proliferative breast disease,associated with familial breast cancer
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Possesses tyrosine phosphatase activity.

Enzyme Numbers (IUBMB) for PTPRG Gene

Gene Ontology (GO) - Molecular Function for PTPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 8382771
genes like me logo Genes that share ontologies with PTPRG: view
genes like me logo Genes that share phenotypes with PTPRG: view

Animal Models for PTPRG Gene

MGI Knock Outs for PTPRG:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRG Gene

Localization for PTPRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRG Gene COMPARTMENTS Subcellular localization image for PTPRG gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PTPRG Gene

Pathways & Interactions for PTPRG Gene

SuperPathways for PTPRG Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPRG: view

Pathways by source for PTPRG Gene

1 Qiagen pathway for PTPRG Gene

Gene Ontology (GO) - Biological Process for PTPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA,TAS 8382771
GO:1903385 NOT regulation of homophilic cell adhesion IMP 21724833
genes like me logo Genes that share ontologies with PTPRG: view

No data available for SIGNOR curated interactions for PTPRG Gene

Drugs & Compounds for PTPRG Gene

(2) Drugs for PTPRG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for PTPRG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTPRG: view

Transcripts for PTPRG Gene

Unigene Clusters for PTPRG Gene

Protein tyrosine phosphatase, receptor type, G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRG Gene

No ASD Table

Relevant External Links for PTPRG Gene

GeneLoc Exon Structure for
PTPRG
ECgene alternative splicing isoforms for
PTPRG

Expression for PTPRG Gene

mRNA expression in normal human tissues for PTPRG Gene

Protein differential expression in normal tissues from HIPED for PTPRG Gene

This gene is overexpressed in Serum (38.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRG Gene



SOURCE GeneReport for Unigene cluster for PTPRG Gene Hs.595541

mRNA Expression by UniProt/SwissProt for PTPRG Gene

P23470-PTPRG_HUMAN
Tissue specificity: Found in a variety of tissues.
genes like me logo Genes that share expression patterns with PTPRG: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PTPRG Gene

Orthologs for PTPRG Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRG 35
  • 90.93 (n)
  • 95.27 (a)
PTPRG 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRG 35
  • 92.56 (n)
  • 95.15 (a)
PTPRG 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprg 35
  • 89.41 (n)
  • 94.52 (a)
Ptprg 16
Ptprg 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPRG 35
  • 99.45 (n)
  • 99.45 (a)
PTPRG 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprg 35
  • 89.89 (n)
  • 94.88 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPRG 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRG 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRG 35
  • 81.59 (n)
  • 88.03 (a)
PTPRG 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRG 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprg 35
  • 75.13 (n)
  • 80.19 (a)
zebrafish
(Danio rerio)
Actinopterygii ptprga 35
  • 69.87 (n)
  • 75 (a)
ca16b 36
  • 67 (a)
OneToMany
ptprga 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6906 37
  • 35 (a)
Ptp69D 37
  • 32 (a)
Ptp99A 37
  • 46 (a)
Ptp99A 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C17H12.3 37
  • 34 (a)
C55B7.3 37
  • 31 (a)
F10G8.1 37
  • 28 (a)
F47B3.1 37
  • 30 (a)
F47B3.6 37
  • 30 (a)
F47B3.7 37
  • 33 (a)
K04D7.4 37
  • 32 (a)
K07F5.8 37
  • 32 (a)
M04G7.2 37
  • 36 (a)
T27A3.5 37
  • 31 (a)
ZK484.7 37
  • 32 (a)
ZK616.7 37
  • 37 (a)
Species with no ortholog for PTPRG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRG Gene

ENSEMBL:
Gene Tree for PTPRG (if available)
TreeFam:
Gene Tree for PTPRG (if available)

Paralogs for PTPRG Gene

Paralogs for PTPRG Gene

genes like me logo Genes that share paralogs with PTPRG: view

Variants for PTPRG Gene

Sequence variations from dbSNP and Humsavar for PTPRG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2292245 - 62,203,515(+) AGGAC(A/G)GCGAG reference, missense
rs9870460 - 62,203,711(+) GCATC(A/G)GACTA reference, missense
rs62620047 - 61,989,708(+) ACCAG(C/T)ATGCG reference, missense
rs166117 -- 61,969,494(-) AAAAG(C/G)ATAAT intron-variant
rs33080 -- 61,966,009(-) ATAGA(C/G/T)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRG Gene

Variant ID Type Subtype PubMed ID
nsv834711 CNV Loss 17160897
nsv822105 CNV Gain 20364138
esv23804 CNV Loss 19812545
dgv1462e1 CNV Complex 17122850
esv35004 CNV Gain 17911159
nsv822106 CNV Gain 20364138
esv2672277 CNV Deletion 23128226
nsv834712 CNV Gain 17160897
nsv876871 CNV Loss 21882294
nsv236686 CNV Loss 16902084
esv2554644 CNV Deletion 19546169
esv2386760 CNV Deletion 18987734
nsv471782 CNV Loss 16327809
esv2725334 CNV Deletion 23290073
esv2599998 CNV Deletion 19546169
esv2658385 CNV Deletion 23128226
esv1001407 CNV Deletion 20482838
esv1631216 CNV Deletion 17803354
esv1005605 CNV Deletion 20482838
esv1217921 CNV Deletion 17803354
dgv5151n71 CNV Gain 21882294
esv2223333 CNV Deletion 18987734
esv2673237 CNV Deletion 23128226
esv2725335 CNV Deletion 23290073
esv2725336 CNV Deletion 23290073
esv2725337 CNV Deletion 23290073
nsv516255 CNV Loss 19592680
nsv523876 CNV Loss 19592680
nsv876874 CNV Loss 21882294
esv2667638 CNV Deletion 23128226
esv2548031 CNV Insertion 19546169
esv2725338 CNV Deletion 23290073
nsv517920 CNV Loss 19592680
esv22782 CNV Loss 19812545
nsv876875 CNV Gain 21882294
esv270382 CNV Insertion 20981092
nsv460575 CNV Gain 19166990
esv259746 OTHER Complex 20981092
nsv437862 CNV Loss 16468122
nsv522606 CNV Loss 19592680

Variation tolerance for PTPRG Gene

Residual Variation Intolerance Score: 5.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRG Gene

HapMap Linkage Disequilibrium report
PTPRG
Human Gene Mutation Database (HGMD)
PTPRG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRG Gene

Disorders for PTPRG Gene

MalaCards: The human disease database

(6) MalaCards diseases for PTPRG Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PTPRG in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPRG

Genetic Association Database (GAD)
PTPRG
Human Genome Epidemiology (HuGE) Navigator
PTPRG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRG
genes like me logo Genes that share disorders with PTPRG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRG Gene

Publications for PTPRG Gene

  1. Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation. (PMID: 8833149) Kastury K. … Huebner K. (Genomics 1996) 3 4 23 67
  2. Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21. (PMID: 1711217) LaForgia S. … Weston A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 23
  3. Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTPgamma) in human breast cancer cell line MCF-7. (PMID: 14676845) Liu S. … Lin Y.C. (Oncogene 2004) 3 23
  4. Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents. (PMID: 11859871) Liu S. … Lin Y.C. (Breast Cancer Res. Treat. 2002) 3 23
  5. Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha. (PMID: 12553013) Liu S. … Lin Y.C. (Anticancer Res. 2002) 3 23

Products for PTPRG Gene

Sources for PTPRG Gene

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