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Aliases for PTPRF Gene

Aliases for PTPRF Gene

  • Protein Tyrosine Phosphatase, Receptor Type F 2 3
  • Leukocyte Common Antigen Related 3 4
  • EC 3.1.3.48 4 63
  • LAR 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide 3
  • Receptor-Linked Protein-Tyrosine Phosphatase LAR 3
  • Leukocyte Antigen-Related Tyrosine Phosphatase 3
  • Protein Tyrosine Phosphatase, Receptor Type, F 5
  • Leukocyte Antigen-Related (LAR) PTP Receptor 3
  • LCA-Homolog 3
  • BNAH2 3

External Ids for PTPRF Gene

Previous HGNC Symbols for PTPRF Gene

  • LAR

Previous GeneCards Identifiers for PTPRF Gene

  • GC01P043874
  • GC01P042996
  • GC01P043426
  • GC01P043409
  • GC01P043665
  • GC01P043769
  • GC01P043990
  • GC01P042115

Summaries for PTPRF Gene

Entrez Gene Summary for PTPRF Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRF Gene

PTPRF (Protein Tyrosine Phosphatase, Receptor Type F) is a Protein Coding gene. Diseases associated with PTPRF include Breasts And/Or Nipples, Aplasia Or Hypoplasia Of, 2 and Isolated Congenital Breast Hypoplasia/Aplasia. Among its related pathways are Transmission across Chemical Synapses and Translation Insulin regulation of translation. GO annotations related to this gene include protein complex binding and phosphatase activity. An important paralog of this gene is PTPRK.

UniProtKB/Swiss-Prot for PTPRF Gene

  • Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.

  • The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

Gene Wiki entry for PTPRF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRF Gene

Genomics for PTPRF Gene

Regulatory Elements for PTPRF Gene

Enhancers for PTPRF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTPRF on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPRF Gene

Chromosome:
1
Start:
43,522,238 bp from pter
End:
43,623,672 bp from pter
Size:
101,435 bases
Orientation:
Plus strand

Genomic View for PTPRF Gene

Genes around PTPRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRF Gene

Proteins for PTPRF Gene

  • Protein details for PTPRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10586-PTPRF_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase F
    Protein Accession:
    P10586
    Secondary Accessions:
    • D3DPX6
    • D3DPX7
    • Q5T021
    • Q5T022
    • Q5W9G2
    • Q86WS0

    Protein attributes for PTPRF Gene

    Size:
    1907 amino acids
    Molecular mass:
    212879 Da
    Quaternary structure:
    • Interacts with GRIP1 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR.
    SequenceCaution:
    • Sequence=BAD66835.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA68754.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRF Gene

    Alternative splice isoforms for PTPRF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRF Gene

Proteomics data for PTPRF Gene at MOPED

Post-translational modifications for PTPRF Gene

  • Ubiquitination at Lys 1303
  • Glycosylation at Asn 117, Asn 250, Asn 295, Asn 721, Asn 959, and Asn 966
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for PTPRF Gene

Suggested Antigen Peptide Sequences for PTPRF Gene

Graphical View of Domain Structure for InterPro Entry

P10586

UniProtKB/Swiss-Prot:

PTPRF_HUMAN :
  • Contains 8 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
Domain:
  • Contains 8 fibronectin type-III domains.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 tyrosine-protein phosphatase domains.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
genes like me logo Genes that share domains with PTPRF: view

Function for PTPRF Gene

Molecular function for PTPRF Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type II,f polypeptide,involved in axon guidance and mammary gland development
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.
UniProtKB/Swiss-Prot Function:
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

Enzyme Numbers (IUBMB) for PTPRF Gene

Gene Ontology (GO) - Molecular Function for PTPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with PTPRF: view
genes like me logo Genes that share phenotypes with PTPRF: view

Human Phenotype Ontology for PTPRF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPRF Gene

MGI Knock Outs for PTPRF:

Animal Model Products

CRISPR Products

miRNA for PTPRF Gene

miRTarBase miRNAs that target PTPRF

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PTPRF Gene

Localization for PTPRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRF Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRF Gene COMPARTMENTS Subcellular localization image for PTPRF gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 2
golgi apparatus 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043025 neuronal cell body IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with PTPRF: view

Pathways & Interactions for PTPRF Gene

genes like me logo Genes that share pathways with PTPRF: view

Pathways by source for PTPRF Gene

1 GeneGo (Thomson Reuters) pathway for PTPRF Gene
1 Qiagen pathway for PTPRF Gene

SIGNOR curated interactions for PTPRF Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PTPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway TAS 8995282
GO:0010975 regulation of neuron projection development IEA --
GO:0031102 neuron projection regeneration IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA,IMP 23358419
genes like me logo Genes that share ontologies with PTPRF: view

Drugs & Compounds for PTPRF Gene

(4) Drugs for PTPRF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for PTPRF Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTPRF: view

Transcripts for PTPRF Gene

Unigene Clusters for PTPRF Gene

Protein tyrosine phosphatase, receptor type, F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ·
SP1: - -
SP2:
SP3:
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9: - -
SP10: - -
SP11:
SP12: - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 16c ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b · 30c ^ 31a · 31b ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14: -
SP15: -
SP16:
SP17: -
SP18:
SP19:

ExUns: 32a · 32b ^ 33a · 33b ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38 ^ 39
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for PTPRF Gene

GeneLoc Exon Structure for
PTPRF
ECgene alternative splicing isoforms for
PTPRF

Expression for PTPRF Gene

mRNA expression in normal human tissues for PTPRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPRF Gene

This gene is overexpressed in Serum (34.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRF Gene



SOURCE GeneReport for Unigene cluster for PTPRF Gene Hs.272062

genes like me logo Genes that share expression patterns with PTPRF: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PTPRF Gene

Orthologs for PTPRF Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRF 35
  • 91.82 (n)
  • 96.31 (a)
PTPRF 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRF 35
  • 91.38 (n)
  • 96.27 (a)
PTPRF 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprf 35
  • 89.02 (n)
  • 95.84 (a)
Ptprf 16
Ptprf 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPRF 35
  • 99.26 (n)
  • 99.79 (a)
PTPRF 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprf 35
  • 89.36 (n)
  • 95.84 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRF 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRF 35
  • 78.1 (n)
  • 85.49 (a)
PTPRF 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRF 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprf 35
  • 72.1 (n)
  • 81.62 (a)
African clawed frog
(Xenopus laevis)
Amphibia XPTP-LAR 35
zebrafish
(Danio rerio)
Actinopterygii ptprfb 35
  • 72.67 (n)
  • 77.45 (a)
ptprfa 36
  • 76 (a)
OneToMany
ptprfb 36
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Lar 37
  • 39 (a)
Ptp52F 37
  • 42 (a)
Ptp69D 37
  • 34 (a)
Lar 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C17H12.3 37
  • 32 (a)
F25H5.7 37
  • 35 (a)
F47B3.7 37
  • 36 (a)
F55F8.7 37
  • 35 (a)
K04D7.4 37
  • 33 (a)
T22C1.8 37
  • 32 (a)
Y48G9A.9 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1998 36
  • 45 (a)
OneToMany
Species with no ortholog for PTPRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRF Gene

ENSEMBL:
Gene Tree for PTPRF (if available)
TreeFam:
Gene Tree for PTPRF (if available)

Paralogs for PTPRF Gene

Paralogs for PTPRF Gene

genes like me logo Genes that share paralogs with PTPRF: view

Variants for PTPRF Gene

Sequence variations from dbSNP and Humsavar for PTPRF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3748796 - 43,591,371(+) CGTCT(A/G)CTATA reference, missense
rs3748800 - 43,592,472(+) CCTTC(A/G)ACCCA reference, missense
rs1065775 - 43,591,257(+) ACAGG(C/T)GCCCT reference, missense
rs530373 -- 43,604,361(+) TCTTG(A/G)TGCCT intron-variant
rs489328 -- 43,608,770(-) TTCGG(A/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRF Gene

Variant ID Type Subtype PubMed ID
nsv871794 CNV Loss 21882294
nsv519570 CNV Loss 19592680
esv2678218 CNV Deletion 23128226
esv2600447 OTHER Inversion 19546169
esv7506 OTHER Inversion 19470904
nsv513636 OTHER Inversion 21212237
esv2659684 CNV Deletion 23128226
nsv822487 CNV Loss 20364138

Variation tolerance for PTPRF Gene

Residual Variation Intolerance Score: 0.343% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRF Gene

Human Gene Mutation Database (HGMD)
PTPRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRF Gene

Disorders for PTPRF Gene

MalaCards: The human disease database

(6) MalaCards diseases for PTPRF Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breasts and/or nipples, aplasia or hypoplasia of, 2
  • breasts and/or nipples, aplasia or hypoplasia 2
isolated congenital breast hypoplasia/aplasia
  • isolated congenital amastia
amyotrophic lateral sclerosis 8
  • amyotrophic lateral sclerosis type 8
ureterocele
separation anxiety disorder
  • separation anxiety disorder of childhood
- elite association - COSMIC cancer census association via MalaCards
Search PTPRF in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PTPRF_HUMAN
  • Aplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2) [MIM:616001]: A group of congenital deformities encompassing total absence of breasts and nipple (amastia), absence of the nipple (athelia), and absence of the mammary gland (amazia). {ECO:0000269 PubMed:24781087}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PTPRF

Genetic Association Database (GAD)
PTPRF
Human Genome Epidemiology (HuGE) Navigator
PTPRF
Tumor Gene Database (TGDB):
PTPRF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRF
genes like me logo Genes that share disorders with PTPRF: view

No data available for Genatlas for PTPRF Gene

Publications for PTPRF Gene

  1. Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells. (PMID: 8995282) Ahmad F. … Goldstein B.J. (J. Biol. Chem. 1997) 3 4 23 67
  2. Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation. (PMID: 20139422) Kwon S.K. … Kim E. (J. Biol. Chem. 2010) 3 23
  3. Protein tyrosine phosphatase regulation in fibroblasts from patients with an insulin receptor gene mutation. (PMID: 18925540) Seki N. … Hashimoto N. (Horm. Metab. Res. 2008) 3 23
  4. Knock-down of LAR protein tyrosine phosphatase induces insulin resistance. (PMID: 15896785) Mander A. … Sale G.J. (FEBS Lett. 2005) 3 23
  5. Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. (PMID: 11931740) Wyszynski M. … Sheng M. (Neuron 2002) 3 23

Products for PTPRF Gene

Sources for PTPRF Gene

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