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Aliases for PTPRF Gene

Aliases for PTPRF Gene

  • Protein Tyrosine Phosphatase, Receptor Type, F 2 3
  • LAR 3 4 6
  • Leukocyte Common Antigen Related 3 4
  • EC 3.1.3.48 4 63
  • Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide 3
  • Receptor-Linked Protein-Tyrosine Phosphatase LAR 3
  • Leukocyte Antigen-Related Tyrosine Phosphatase 3
  • Leukocyte Antigen-Related (LAR) PTP Receptor 3
  • Receptor-Type Tyrosine-Protein Phosphatase F 3
  • LCA-Homolog 3
  • BNAH2 3

External Ids for PTPRF Gene

Previous HGNC Symbols for PTPRF Gene

  • LAR

Previous GeneCards Identifiers for PTPRF Gene

  • GC01P043874
  • GC01P042996
  • GC01P043426
  • GC01P043409
  • GC01P043665
  • GC01P043769
  • GC01P043990
  • GC01P042115

Summaries for PTPRF Gene

Entrez Gene Summary for PTPRF Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRF Gene

PTPRF (Protein Tyrosine Phosphatase, Receptor Type, F) is a Protein Coding gene. Diseases associated with PTPRF include breasts and/or nipples, aplasia or hypoplasia of, 2 and isolated breast aplasia. Among its related pathways are PAK Pathway and Adherens junction. GO annotations related to this gene include heparin binding and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRT.

UniProtKB/Swiss-Prot for PTPRF Gene

  • Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity

  • The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one

Gene Wiki entry for PTPRF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRF Gene

Genomics for PTPRF Gene

Regulatory Elements for PTPRF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPRF Gene

Start:
43,525,187 bp from pter
End:
43,623,672 bp from pter
Size:
98,486 bases
Orientation:
Plus strand

Genomic View for PTPRF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRF Gene

Proteins for PTPRF Gene

  • Protein details for PTPRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10586-PTPRF_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase F
    Protein Accession:
    P10586
    Secondary Accessions:
    • D3DPX6
    • D3DPX7
    • Q5T021
    • Q5T022
    • Q5W9G2
    • Q86WS0

    Protein attributes for PTPRF Gene

    Size:
    1907 amino acids
    Molecular mass:
    212879 Da
    Quaternary structure:
    • Interacts with GRIP1 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR.
    SequenceCaution:
    • Sequence=BAD66835.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA68754.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRF Gene

    Alternative splice isoforms for PTPRF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRF Gene

Proteomics data for PTPRF Gene at MOPED

Post-translational modifications for PTPRF Gene

  • Ubiquitination at Lys1303
  • Glycosylation at Asn117, Asn250, Asn295, Asn721, Asn959, and Asn966
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for PTPRF Gene

Gene Families for PTPRF Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • PTPR :Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like
IUPHAR :

Suggested Antigen Peptide Sequences for PTPRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10586

UniProtKB/Swiss-Prot:

PTPRF_HUMAN :
  • P10586
Domain:
  • Contains 8 fibronectin type-III domains.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 tyrosine-protein phosphatase domains.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
genes like me logo Genes that share domains with PTPRF: view

Function for PTPRF Gene

Molecular function for PTPRF Gene

GENATLAS Biochemistry: protein tyrosine phosphatase,receptor-type II,f polypeptide,involved in axon guidance and mammary gland development
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity
UniProtKB/Swiss-Prot Function: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one

Enzyme Numbers (IUBMB) for PTPRF Gene

Gene Ontology (GO) - Molecular Function for PTPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IMP 23358419
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 8995282
GO:0005515 protein binding --
GO:0008201 heparin binding IEA --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPRF: view
genes like me logo Genes that share phenotypes with PTPRF: view

Animal Models for PTPRF Gene

MGI Knock Outs for PTPRF:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRF

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PTPRF Gene

Localization for PTPRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRF Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRF Gene COMPARTMENTS Subcellular localization image for PTPRF gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
extracellular 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 2972792
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with PTPRF: view

Pathways for PTPRF Gene

genes like me logo Genes that share pathways with PTPRF: view

Pathways by source for PTPRF Gene

1 Qiagen pathway for PTPRF Gene
2 BioSystems pathways for PTPRF Gene
1 GeneGo (Thomson Reuters) pathway for PTPRF Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0007155 cell adhesion IEA --
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway TAS 8995282
GO:0016311 dephosphorylation --
GO:0016477 cell migration IMP 23358419
genes like me logo Genes that share ontologies with PTPRF: view

Compounds for PTPRF Gene

(2) HMDB Compounds for PTPRF Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(7) Novoseek inferred chemical compound relationships for PTPRF Gene

Compound -log(P) Hits PubMed IDs
tyrosine 73.4 50
phosphotyrosine 60.4 2
cysteine 4.02 3
threonine 3.33 1
glucose 0 2
genes like me logo Genes that share compounds with PTPRF: view

Transcripts for PTPRF Gene

Unigene Clusters for PTPRF Gene

Protein tyrosine phosphatase, receptor type, F:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRF

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ·
SP1: - -
SP2:
SP3:
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9: - -
SP10: - -
SP11:
SP12: - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 16c ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b · 30c ^ 31a · 31b ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14: -
SP15: -
SP16:
SP17: -
SP18:
SP19:

ExUns: 32a · 32b ^ 33a · 33b ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38 ^ 39
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for PTPRF Gene

GeneLoc Exon Structure for
PTPRF
ECgene alternative splicing isoforms for
PTPRF

Expression for PTPRF Gene

mRNA expression in normal human tissues for PTPRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRF Gene

SOURCE GeneReport for Unigene cluster for PTPRF Gene Hs.272062

genes like me logo Genes that share expressions with PTPRF: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTPRF Gene

Orthologs for PTPRF Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRF 35
  • 99.26 (n)
  • 99.79 (a)
PTPRF 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRF 35
  • 91.82 (n)
  • 96.31 (a)
PTPRF 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRF 35
  • 91.38 (n)
  • 96.27 (a)
PTPRF 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprf 35
  • 89.02 (n)
  • 95.84 (a)
Ptprf 16
Ptprf 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRF 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprf 35
  • 89.36 (n)
  • 95.84 (a)
chicken
(Gallus gallus)
Aves PTPRF 35
  • 78.1 (n)
  • 85.49 (a)
PTPRF 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRF 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia XPTP-LAR 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprf 35
  • 72.1 (n)
  • 81.62 (a)
zebrafish
(Danio rerio)
Actinopterygii ptprfa 36
  • 76 (a)
OneToMany
ptprfb 35
  • 72.67 (n)
  • 77.45 (a)
ptprfb 36
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Lar 36
  • 47 (a)
OneToMany
Lar 37
  • 39 (a)
Ptp69D 37
  • 34 (a)
Ptp52F 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea F25H5.7 37
  • 35 (a)
T22C1.8 37
  • 32 (a)
K04D7.4 37
  • 33 (a)
F55F8.7 37
  • 35 (a)
C17H12.3 37
  • 32 (a)
F47B3.7 37
  • 36 (a)
Y48G9A.9 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1998 36
  • 45 (a)
OneToMany
Species with no ortholog for PTPRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRF Gene

ENSEMBL:
Gene Tree for PTPRF (if available)
TreeFam:
Gene Tree for PTPRF (if available)

Paralogs for PTPRF Gene

Paralogs for PTPRF Gene

genes like me logo Genes that share paralogs with PTPRF: view

Variants for PTPRF Gene

Sequence variations from dbSNP and Humsavar for PTPRF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs489328 -- 43,608,770(-) TTCGG(A/G)AAGAA intron-variant
rs492929 -- 43,602,604(+) ATGAC(A/G)GCTCT intron-variant
rs499257 -- 43,612,713(+) GGGCT(C/T)TCTTT intron-variant
rs501299 -- 43,586,163(+) ACAGC(A/C)TGGAA intron-variant
rs510930 -- 43,606,023(+) GTGGG(G/T)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRF Gene

Variant ID Type Subtype PubMed ID
nsv871794 CNV Loss 21882294
nsv519570 CNV Loss 19592680
esv2678218 CNV Deletion 23128226
esv2600447 OTHER Inversion 19546169
esv7506 OTHER Inversion 19470904
nsv513636 OTHER Inversion 21212237
esv2659684 CNV Deletion 23128226
nsv822487 CNV Loss 20364138

Relevant External Links for PTPRF Gene

HapMap Linkage Disequilibrium report
PTPRF
Human Gene Mutation Database (HGMD)
PTPRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRF Gene

Disorders for PTPRF Gene

UniProtKB/Swiss-Prot

PTPRF_HUMAN
  • Aplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2) [MIM:616001]: A group of congenital deformities encompassing total absence of breasts and nipple (amastia), absence of the nipple (athelia), and absence of the mammary gland (amazia). {ECO:0000269 PubMed:24781087}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for PTPRF Gene

(9) Novoseek inferred disease relationships for PTPRF Gene

Disease -log(P) Hits PubMed IDs
neuroectodermal tumors 60.1 1
pheochromocytoma 42 6
insulin resistance 40 10
insulin sensitivity 19.9 3
obesity 0.882 1

Relevant External Links for PTPRF

Genetic Association Database (GAD)
PTPRF
Human Genome Epidemiology (HuGE) Navigator
PTPRF
Tumor Gene Database (TGDB):
PTPRF
genes like me logo Genes that share disorders with PTPRF: view

Publications for PTPRF Gene

  1. Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR. (PMID: 1695146) Streuli M. … Saito H. (EMBO J. 1990) 3 4 23
  2. Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells. (PMID: 8995282) Ahmad F. … Goldstein B.J. (J. Biol. Chem. 1997) 3 4 23
  3. Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR. (PMID: 8732688) Zhang W.R. … Goldstein B.J. (Mol. Endocrinol. 1996) 3 23
  4. The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR. (PMID: 9647658) O'Grady P. … Saito H. (J. Cell Biol. 1998) 3 23
  5. Leukocyte common antigen-related tyrosine phosphatase receptor: increased expression and neuronal-type splicing in breast cancer cells and tissue. (PMID: 10365916) Yang T. … Longo F.M. (Mol. Carcinog. 1999) 3 23

Products for PTPRF Gene

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