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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PTPRF Gene

protein-coding GIFtS: 72
GCID: GC01P043990

protein tyrosine phosphatase, receptor type, F

(Previous symbol: LAR)

Explore 16 diseases affiliated with
PTPRF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Receptor Type, F¹ ²		Leukocyte Antigen-Related (LAR) PTP Receptor²
LAR¹ ² ³ ⁵		Leukocyte Antigen-Related Tyrosine Phosphatase²
Leukocyte Common Antigen Related² ³		Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide²
EC 3.1.3.48³ ⁸		Receptor-Linked Protein-Tyrosine Phosphatase LAR²
LCA-Homolog¹		Receptor-Type Tyrosine-Protein Phosphatase F²

External Ids:	HGNC: 9670¹	Entrez Gene: 5792²	Ensembl: ENSG00000142949⁷	OMIM: 179590⁵	UniProtKB: P10586³

Export aliases for PTPRF gene to outside databases

Previous GC identifers: GC01P043874 GC01P042996 GC01P043426 GC01P043409 GC01P043665 GC01P043769 GC01P042115

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPRF:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be

signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic

cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and

two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region

contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This

PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the

control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive

tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two

alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. (provided

by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PTPRF_HUMAN, P10586

Function: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase)

Function: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate

specificity of the first one

Gene Wiki entry for PTPRF

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTPRF gene promoter:
CREB GR deltaCREB GR-beta GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTPRF promoter sequence

Search SABiosciences Chromatin IP Primers for PTPRF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPRF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34

PTPRF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRF gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P043990: view genomic region (about GC identifiers)

Start:	43,990,858 bp from pter	End:	44,089,343 bp from pter
Size:	98,486 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PTPRF_HUMAN, P10586 (See protein sequence)

Recommended Name: Receptor-type tyrosine-protein phosphatase F precursor

Size: 1907 amino acids; 212879 Da

Subunit: Interacts with GRIP1 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR

Subcellular location: Membrane; Single-pass type I membrane protein

Sequence caution: Sequence=BAD66835.1; Type=Erroneous initiation; Sequence=CAA68754.1; Type=Erroneous initiation;

6/7 PDB 3D structures from and Proteopedia for PTPRF (see all 7):

1LAR (3D)

2DJU (3D)

2DN7 (3D)

2EDX (3D)

2EDY (3D)

2YD5 (3D)

Secondary accessions: D3DPX6 D3DPX7 Q5T021 Q5T022 Q5W9G2 Q86WS0

Alternative splicing: 2 isoforms: P10586-1 P10586-2

Explore the universe of human proteins at neXtProt for PTPRF: NX_P10586

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10586

4/80 DME Specific Peptides for PTPRF (P10586) (see all 80)

DPVEMRR

QVFAKNF

ERLKAND

YIATQGP

PTPRF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_002831.2 NP_569707.2

ENSEMBL proteins:

ENSP00000353030 ENSP00000398822 ENSP00000413306 ENSP00000391764 ENSP00000408952

ENSP00000416343 ENSP00000361484 ENSP00000361491 ENSP00000361490 ENSP00000387885

Human Recombinant Protein Products:

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	Enzo Life Sciences proteins for PTPRF
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	Novus Biologicals PTPRF Proteins Novus Biologicals PTPRF Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PTPRF

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005626	insoluble fraction	--	--
GO:0005768	endosome	--	--
GO:0005792	microsome	--	--
GO:0005886	plasma membrane	--	--

PTPRF for ontologies About GeneDecksing

PTPRF Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PTPRF
	R&D Systems Antibodies for PTPRF (LAR)
	Browse OriGene Antibodies OriGene Custom Antibody Services for PTPRF
	GenScript Custom Superior Antibodies Services for PTPRF
	Novus Biologicals PTPRF Antibodies
	Search for Antibodies for PTPRF at Abcam
	Uscn Antibodies for PTPRF
	ThermoFisher Antibodies for PTPRF

Assay Products for PTPRF:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PTPRF
	Enzo Life Sciences assays for PTPRF
	Uscn ELISAs and CLIAs for PTPRF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTPRF for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR003598 Ig_sub2

IPR003961 Fibronectin_type3

IPR013098 Ig_I-set

IPR016130 Tyr_Pase_AS

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry P10586

ProtoNet protein and cluster: P10586

4 Blocks protein families:

IPB000242 Protein tyrosine phosphatase signature

IPB003598 Immunoglobulin C-2 type

IPB003962 Fibronectin type III repeat signature

IPB013098 Immunoglobulin I-set

UniProtKB/Swiss-Prot: PTPRF_HUMAN, P10586

Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily

Similarity: Contains 8 fibronectin type-III domains

Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 2 tyrosine-protein phosphatase domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PTPRF_HUMAN, P10586

Function: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase)

Function: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate

specificity of the first one

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Genatlas biochemistry entry for PTPRF:

protein tyrosine phosphatase,receptor-type II,f polypeptide,involved in axon guidance and mammary gland development

Enzyme Number (IUBMB): EC 3.1.3.48¹ ²

miRNA Products:		miRTarBase miRNAs that target PTPRF: hsa-mir-1 (MIRT001340)

		OriGene 3'-UTR Clone (see all 2): PTPRF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPRF
		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPRF (see all 47):
		hsa-miR-323-3p hsa-miR-607 hsa-miR-328 hsa-miR-4272 hsa-miR-199a-3p hsa-miR-765 hsa-miR-624* hsa-miR-624

		SwitchGear 3'UTR luciferase reporter plasmid: PTPRF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPRF (see all 7) OriGene shRNA RFP: PTPRF OriGene siRNA: PTPRF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPRF

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PTPRF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRF (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRF (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PTPRF (NM_002840)
		Browse Sino Biological Human cDNA Clones
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRF

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PTPRF
		Search LifeMap BioReagents cell lines for PTPRF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRF

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004725	protein tyrosine phosphatase activity	IDA	10338209
GO:0004872	receptor activity	--	--
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	TAS	8995282
GO:0005158	insulin receptor binding	--	--
GO:0008201	heparin binding	IEA	--

PTPRF for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for PTPRF:

Cells with protrusions	Decreased focal adhesion (FA)	Increased cell death HMECs cel	Synthetic lethal with paclitax
Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Ptprf^tm1Wjh for PTPRF
12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ptprf):

behavior/neurological	cellular	craniofacial	digestive/alimentary	endocrine/exocrine gland
immune system	integument	mortality/aging	nervous system	renal/urinary system
skeleton	vision/eye

PTPRF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeleton remodeling Slit-Robo signaling

Cell adhesion Cadherin-mediated cell adhesion

0.28

Cell adhesion_Cadherin-mediated cell adhesion

0.28

Insulin Signaling

Insulin Signaling

1.00

Adherens junction

Adherens junction

1.00

Cell adhesion molecules (CAMs)

Cell adhesion molecules (CAMs)

1.00

PAK Pathway

Epithelial Adherens Junctions

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PTPRF

Cell adhesion Cadherin-mediated cell adhesion

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPRF

Epithelial Adherens Junctions

1 GeneGo (Thomson Reuters) Pathway for PTPRF

Cell adhesion Cadherin-mediated cell adhesion

1 BioSystems Pathway for PTPRF

Insulin Signaling

3 Kegg Pathways (Kegg details for PTPRF):

	Cell adhesion molecules (CAMs)
	Adherens junction
	Insulin signaling pathway

PTPRF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTPRF

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/36 Interacting proteins for PTPRF (P10586^{2, 3} ENSP00000353030⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CAV1	Q03135²^,³, ENSP00000339191⁴	MINT-6793831 MINT-6793873 I2D: score=5 STRING: ENSP00000339191
PRPF40A	O75400²^,³	MINT-61846 I2D: score=3
SKIL	P12757²^,³	MINT-61632 I2D: score=3
ZNF512B	Q96KM6²^,³	MINT-60803 I2D: score=2
JUP	P14923³, ENSP00000311113⁴	I2D: score=4 STRING: ENSP00000311113

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001960	negative regulation of cytokine-mediated signaling pathway	--	--
GO:0006470	protein dephosphorylation	--	--
GO:0007155	cell adhesion	IEA	--
GO:0007156	homophilic cell adhesion	--	--
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	TAS	8995282

PTPRF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PTPRF for compounds About GeneDecksing

EMD Millipore small molecules for PTPRF:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PTPRF

2 HMDB Compounds for PTPRF About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

7 Novoseek chemical compound relationships for PTPRF gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	73.4	59	11158333 (4), 11121408 (3), 15840365 (2), 1547787 (2) (see all 39)
phosphotyrosine	60.4	2	7665159 (1), 1317540 (1)
cysteine	4.02	3	1695146 (2), 11158333 (1)
threonine	3.33	2	9548949 (1)
glucose	0	3	9545023 (1), 9562610 (1)
serine	0	3	11158333 (1), 9548949 (1)
h2o2	0	2	9548949 (1)

Search CenterWatch for drugs/clinical trials and news about PTPRF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PTPRF gene (2 alternative transcripts):

NM_002840.3 NM_130440.2

Unigene Cluster for PTPRF:

Protein tyrosine phosphatase, receptor type, F

Hs.272062 [show with all ESTs]

Unigene Representative Sequence: NM_002840

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000496043 ENST00000481019 ENST00000359947(uc001cjr.3 uc001cjs.3)

ENST00000438120 ENST00000436724(uc001cjq.4) ENST00000372405(uc001cjt.4)

ENST00000437607 ENST00000467464 ENST00000412568 ENST00000429895 ENST00000414879

ENST00000496447(uc001cjw.3) ENST00000372407 ENST00000463041 ENST00000477970

ENST00000372414(uc001cju.3) ENST00000372413(uc009vwt.3 uc001cjv.3)

ENST00000422171

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PTPRF Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPRF
		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPRF (see all 47):
		hsa-miR-323-3p hsa-miR-607 hsa-miR-328 hsa-miR-4272 hsa-miR-199a-3p hsa-miR-765 hsa-miR-624* hsa-miR-624

		SwitchGear 3'UTR luciferase reporter plasmid: PTPRF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRF (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRF (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPRF Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPRF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPRF

Additional cDNA sequence:

AB177856.1 AB177857.1 AB209478.1 AB621807.1 AK125325.1 AK127007.1 AK127475.1 AK301551.1

BC029466.1 BC048768.1 BX537361.1 DQ234351.1

24/35 DOTS entries (see all 35):

DT.95100963 DT.100717721 DT.95101008 DT.91825019 DT.448524 DT.101984819 DT.97856682 DT.95233803

DT.100717233 DT.100828055 DT.121441771 DT.95101012 DT.100726133 DT.85104160 DT.91978088 DT.95101005

DT.95158788 DT.100828049 DT.121441659 DT.95303747 DT.97795787 DT.121441628 DT.121441649 DT.121441671

24/713 AceView cDNA sequences (see all 713):

AU118895 CA773870 CA419474 CK300316 BM837252 AA644280 AW795360 AA350212

AI431914 AI888742 AA614359 CB306416 BU618513 BQ187911 AA614596 BQ890086

BF870524 H59579 CK000109 BM793169 AI092497 CA422920 AW071582 CD615871

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for PTPRF (see all 19) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	·
SP1:																																																	-		-
SP2:
SP3:
SP4:
SP5:											-																				-

ExUns:	16c	^	17a	·	17b	^	18	^	19	^	20a	·	20b	^	21	^	22	^	23	^	24a	·	24b	^	25a	·	25b	·	25c	^	26	^	27	^	28a	·	28b	^	29a	·	29b	^	30a	·	30b	·	30c	^	31a	·	31b	^
SP1:	-		-				-																												-				-						-		-		-
SP2:							-																										-		-				-						-		-		-
SP3:											-		-																						-				-						-		-		-
SP4:																																							-						-		-		-
SP5:

ExUns:	32a	·	32b	^	33a	·	33b	^	34	^	35a	·	35b	^	36	^	37	^	38	^	39
SP1:													-
SP2:													-
SP3:													-
SP4:
SP5:

ECgene alternative splicing isoforms for PTPRF

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PTPRF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTGGGGTT

About this image

PTPRF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Visceral White Adipocytes

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PTPRF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTPRF

SOURCE GeneReport for Unigene cluster: Hs.272062

SABiosciences Expression via Pathway-Focused PCR Arrays including PTPRF:

Insulin Signaling Pathway in human mouse rat

Protein Phosphatases in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPRF Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPRF

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PTPRF gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PTPRF¹	protein tyrosine phosphatase, receptor type, F	78.17(n) 85.65(a)		424568 XM_001233493.2 XP_001233494.1
lizard (Anolis carolinensis)	Reptilia	PTPRF⁶ --	--	82(a) 35(a)	1 ↔ 1 possible ortholog	4(108205478-108333497) GL343358.1(365807-375201)
African clawed frog (Xenopus laevis)	Amphibia	XPTP-LAR²	receptor protein tyrosine phosphatase LAR	74.85(n)		AF197945.1
zebrafish (Danio rerio)	Actinopterygii	ptprda⁶ ptprfb⁶ (see all 4)	protein tyrosine phosphatase, receptor type, f, b (see all 4)	90(a) 76(a) (see all 4)	possible ortholog 1 ↔ many (see all 4)	7(75006179-75013089) 2(17349918-17599781)
fruit fly (Drosophila melanogaster)	Insecta	Ptp52F³	axon guidance protein tyrosine phosphatase	42(a) (best of 3)		52F3 --
worm (Caenorhabditis elegans)	Secernentea	F47B3.7³	--	36(a) (best of 7)		I(3968166-3969943) --

ENSEMBL Gene Tree for PTPRF (if available)
TreeFam Gene Tree for PTPRF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PTPRF gene

PTPRK² PTPRC² PTPRA² PTPRG² PTPRS² PTPRD² PTPRM² PTPRU²

PTPRZ1² PTPRT² PTPRE²

18/36 SIMAP similar genes for PTPRF using alignment to 8 protein entries: PTPRF_HUMAN (see all proteins) (see all similar genes):

BPTP-2 DKFZp686B1310 LAR PTPRD PTPRS DKFZp313F1310

DKFZp781C1038 PTPsigma PTPRA PTPN5 PTPN12 DKFZp566K0524

PTPN20A PTPN20B PTPN7 PTPRE DKFZp761A0712 BPTP-3

PTPRF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187482117^1,2		--	43994795(+)	`TCTGGA/GAAAAA`	2	--	us2k¹		0	--	--	--	--
rs150408759^1,2		--	43994977(+)	`GGGGGC/TGCACA`	2	--	us2k¹		0	--	--	--	--
rs192042632^1,2		--	43994983(+)	`GCACAC/TGCACT`	2	--	us2k¹		0	--	--	--	--
rs138124229^1,2		--	43995030(+)	`GAATCA/GGGTGG`	2	--	us2k¹		0	--	--	--	--
rs185063649^1,2		--	43995073(+)	`TGAACA/GCCACA`	2	--	us2k¹		0	--	--	--	--
rs78447190^1,2		--	43995267(+)	`TAGGTC/TCCCCA`	2	--	us2k¹		2		CSA WA	120
rs189375912^1,2		--	43995297(+)	`GCAAGC/TGGCGG`	2	--	us2k¹		0	--	--	--	--
rs115962047^1,2	F,	--	43995355(+)	`TGACTC/TTTAAG`	2	--	us2k¹		1		WA	118
rs180936601^1,2		--	43995415(+)	`TGGATC/TGAAGC`	2	--	us2k¹		0	--	--	--	--
rs12094591^1,2	C,F,H,	--	43995465(+)	`TTCAGG/ATAGGT`	2	--	us2k¹		12		NS EA NA WA	1306

HapMap Linkage Disequilibrium report for PTPRF (43990858 - 44089343 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for PTPRF
5 CNVs: 48326 84200 84201 48325 74464
2 Inversions: 59654 103306
Human Gene Mutation Database (HGMD): PTPRF

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPRF

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PTPRF for disorders           About GeneDecksing

OMIM gene information: 179590    OMIM disorders: --

16 diseases for PTPRF:    About MalaCards

insulin resistance obesity ureterocele neuroectodermal tumors

pheochromocytoma paraganglioma keratoconus breast cancer

thyroid carcinoma ovarian cancer thyroiditis lung cancer

carcinoma retinitis melanoma neuronitis

1 disease from the University of Copenhagen DISEASES database for PTPRF:

Ureterocele

9 Novoseek disease relationships for PTPRF gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neuroectodermal tumors	60.1	1	8253779 (1)
pheochromocytoma	42	7	8253779 (2), 1486801 (1), 11121408 (1), 12045857 (1) (see all 5)
insulin resistance	40	11	11309481 (3), 9322796 (2), 18925540 (2), 15031294 (2) (see all 5)
insulin sensitivity	19.9	3	12678846 (2), 9322796 (1)
obesity	0.882	1	9322796 (1)
breast cancer	0	11	10365916 (5)
tumors	0	13	10657947 (3), 1486801 (2), 1547787 (1), 8097963 (1) (see all 7)
carcinoma	0	1	12698188 (1)
cancer	0	2	16198483 (1)

Genetic Association Database (GAD): PTPRF
Human Genome Epidemiology (HuGE) Navigator: PTPRF (3 documents)
Tumor Gene Database (TGDB): PTPRF

Export disorders for PTPRF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PTPRF gene, integrated from 9 sources (see all 115):
(articles sorted by number of sources associating them with PTPRF)

Utopia: connect your pdf to the dynamic
world of online information

Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells. (PubMed id 8995282)^{1, 2, 9} Ahmad F. and Goldstein B.J. (1997)
Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR. (PubMed id 1695146)^{1, 2, 9} Streuli M.... Saito H. (1990)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
The allelic variant of LAR gene promoter -127 bp T-->A is associated with reduced risk of obesity and other features related to insulin resistance. (PubMed id 15150650)^{1, 4} Miscio G....Trischitta V. (2004)
Alternative splice variants encoding unstable protein domains exist in the human brain. (PubMed id 15491607)^{1, 2} Homma K.... Nishikawa K. (2004)
Crystal structure of the tandem phosphatase domains of RPTP LAR. (PubMed id 10338209)^{1, 2} Nam H.J.... Frederick C.A. (1999)
Liprins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins. (PubMed id 9624153)^{1, 2} Serra-Pages C.... Streuli M. (1998)
Coexisting amplifications of the chromosome 1p32 genes (PTPRF and MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a small cell lung cancer line. (PubMed id 7558042)^{1, 3} Harder K.W....Jirik F. (1995)
A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila. (PubMed id 2554325)^{1, 2} Streuli M.... Saito H. (1989)
A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen. (PubMed id 2972792)^{1, 2} Streuli M.... Saito H. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5792	HGNC: 9670	AceView: PTPRF	Ensembl:ENSG00000142949	euGenes: HUgn5792
ECgene: PTPRF	Kegg: 5792	H-InvDB: PTPRF

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PTPRF	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PTPRF	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PTPRF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PTPRF gene:
Search GeneIP for patents involving PTPRF

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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protein tyrosine phosphatase, receptor type, F

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PTPRF Gene

protein tyrosine phosphatase, receptor type, F

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