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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPRE Gene

protein-coding   GIFtS: 66
GCID: GC10P129705

protein tyrosine phosphatase, receptor type, E
 Explore 10 diseases affiliated with
PTPRE via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PTPRE    

Aliases
for PTPRE gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Tyrosine Phosphatase, Receptor Type, E1 2     Protein Tyrosine Phosphatase, Receptor Type, Epsilon Polypeptide2
PTPE1 2     Receptor-Type Tyrosine-Protein Phosphatase Epsilon2
EC 3.1.3.483 8     R-PTP-Epsilon1
HPTPE2     Protein-Tyrosine Phosphatase Epsilon3
R-PTP-EPSILON2     

External Ids:    HGNC: 96691   Entrez Gene: 57912   Ensembl: ENSG000001323347   OMIM: 6009265   UniProtKB: P234693   

Export aliases for PTPRE gene to outside databases

Previous GC identifers: GC10P128518 GC10P128746 GC10P129634 GC10P129179 GC10P129595 GC10P123280


Summaries
for PTPRE gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PTPRE:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic
cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported,
one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region,
and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic
N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested
the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as
well as the activation of voltage-gated K+ channels. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PTPRE_HUMAN, P23469
Function: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red
blood cells. May play a role in osteoclast formation and function (By similarity)
Function: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates
insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1),
phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake
(By similarity)
Function: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine
production and degranulation, most likely by acting at the level of SYK to affect downstream events such as
phosphorylation of SLP76 and LAT and mobilization of Ca(2+) (By similarity)

Gene Wiki entry for PTPRE


Genomic Views
for PTPRE gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008818.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPRE gene promoter:
         E2F-4   E2F-3a   E2F-5   Tal-1   Bach2   E2F-2   E47   E2F   E2F-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTPRE promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPRE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPRE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.2   HGNC cytogenetic band: 10q26

PTPRE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRE gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P129705:  view genomic region     (about GC identifiers)

Start:
 129,705,325 bp from pter      End:
 129,884,180 bp from pter
Size:
 178,856 bases      Orientation:
 plus strand

Proteins
for PTPRE gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PTPRE_HUMAN, P23469 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein phosphatase epsilon precursor  
Size: 700 amino acids; 80642 Da
Subunit: Monomer. Isoform 2: Homodimer. Can form oligomers. Dimerization is increased by oxidative stress and decreased
by EGFR. Isoform 2 interacts with GRB2 (By similarity)
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with
nucleus and membrane. Insulin induces translocation to the membrane (By similarity)
Subcellular location: Isoform 3: Cytoplasm
Sequence caution: Sequence=AAC50324.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown
origin in the C-terminal part;
1 PDB 3D structure from and Proteopedia for PTPRE:
2JJD (3D)    
Secondary accessions: Q13345 Q5VWH3 Q5VWH4 Q96KQ6
Alternative promoter usage, Alternative initiation: 3 isoforms:  P23469-1   P23469-2   P23469-3   (Produced by alternative initiation at Met-86 of isoform 1)

Explore the universe of human proteins at neXtProt for PTPRE: NX_P23469

Post-translational modifications:

  • A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or
    • isoform 31
  • Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu1
  • Isoform 1 is glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P23469

    • 4/16 DME Specific Peptides for PTPRE (P23469) (see all 16)
     KCHQYWP  PIVVHCS  DYINASF  VVHCSAG 

    PTPRE Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_006495.1  NP_569119.1  

    ENSEMBL proteins: 
     ENSP00000254667   ENSP00000410540   ENSP00000416939   ENSP00000303350   ENSP00000402337  
     ENSP00000413930  

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    Novus Biologicals PTPRE Protein
    Novus Biologicals PTPRE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PTPRE

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10980613
    GO:0005737cytoplasm IDA10980613
    GO:0005886plasma membrane IDA10980613
    GO:0016021integral to membrane IEA--
    GO:0045111intermediate filament cytoskeleton IDA--


    PTPRE for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PTPRE

    Protein Domains /
    Families
    for PTPRE gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTPRE for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase
     IPR016336 Tyr_Pase_rcpt_a/e-type

    Graphical View of Domain Structure for InterPro Entry P23469

    ProtoNet protein and cluster: P23469

    1 Blocks protein family: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTPRE_HUMAN, P23469
    Domain: The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2
    domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity
    (By similarity)
    Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily
    Similarity: Contains 2 tyrosine-protein phosphatase domains


    Function
    for PTPRE gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PTPRE_HUMAN, P23469
    Function: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red
    blood cells. May play a role in osteoclast formation and function (By similarity)
    Function: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates
    insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1),
    phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake
    (By similarity)
    Function: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine
    production and degranulation, most likely by acting at the level of SYK to affect downstream events such as
    phosphorylation of SLP76 and LAT and mobilization of Ca(2+) (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Induction: Up-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) in HL-60 cells

         Genatlas biochemistry entry for PTPRE:
    protein tyrosine phosphatase,receptor-type IV,epsilon polypeptide

    Enzyme Number (IUBMB): EC 3.1.3.481 2

    miRNA
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    hsa-miR-300 hsa-miR-199a-3p hsa-miR-3142 hsa-miR-383 hsa-miR-374b* hsa-miR-4306 hsa-miR-199a-5p hsa-miR-380
    SwitchGear 3'UTR luciferase reporter plasmid: PTPRE 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPRE (see all 6)
    OriGene shRNA RFP: PTPRE
    OriGene siRNA: PTPRE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPRE

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPRE (see all 4)
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    Search LifeMap BioReagents cell lines for PTPRE

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRE

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0004872receptor activity ----
    GO:0005001transmembrane receptor protein tyrosine phosphatase activity TAS2170109
    GO:0005515protein binding IPI10980613
    GO:0042803protein homodimerization activity IEA--


    PTPRE for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for PTPRE:
     Actin fiber cells  Decreased focal adhesion (FA)   Increased cell death in HCC-19  Increased cell death in breast 

    Animal Models:
         Mouse knock-out Ptpretm1Ael for PTPRE
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ptpre):
     cellular  hematopoietic system  immune system  limbs/digits/tail  nervous system 
     skeleton 

    PTPRE for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PTPRE gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Erk Interactions: Inhibition of Erk
    		Signal transduction Erk Interactions: Inhibition of Erk1.00
    		Signal transduction_Erk Interactions- Inhibition of Erk0.92
    2PAK Pathway
    		Epithelial Adherens Junctions0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PTPRE
        Signal transduction Erk Interactions- Inhibition of Erk

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPRE
        Epithelial Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for PTPRE
        Signal transduction Erk Interactions- Inhibition of Erk



    PTPRE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPRE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/17 Interacting proteins for PTPRE (P234692, 3 ENSP000002546674) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8216985 I2D: score=4 STRING: ENSP00000357656
    KCNA5P224603, ENSP000002523214I2D: score=2 STRING: ENSP00000252321
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    PDGFRBP096193, ENSP000002617994I2D: score=1 STRING: ENSP00000261799
    PTPRDP234683, ENSP000003488124I2D: score=1 STRING: ENSP00000348812
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IEA--
    GO:0006470protein dephosphorylation TAS2170109
    GO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway IEA--
    GO:0033003regulation of mast cell activation IEA--
    GO:0035335peptidyl-tyrosine dephosphorylation ----


    PTPRE for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTPRE gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTPRE for compounds           About GeneDecksing

    EMD Millipore small molecules for PTPRE:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPRE

    2 HMDB Compounds for PTPRE    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PTPRE    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AlendronateAcide Alendronique [INN-French] (see all 5)66376-36-1targetinhibitor8610169

    3 Novoseek chemical compound relationships for PTPRE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 60.6 21 17486066 (2), 8618876 (2), 12460648 (2), 12193229 (2) (see all 14)
    potassium 41.4 2 17486066 (1)
    glycogen 27.4 1 17400802 (1)

    Search CenterWatch for drugs/clinical trials and news about PTPRE 

    Transcripts
    for PTPRE gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTPRE gene (2 alternative transcripts): 
    NM_006504.4  NM_130435.3  

    Unigene Cluster for PTPRE:

    Protein tyrosine phosphatase, receptor type, E
    Hs.127022  [show with all ESTs]
    Unigene Representative Sequence: NM_006504
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254667(uc001lkb.3 uc009yat.3 uc009yau.2) ENST00000442830
    ENST00000471218 ENST00000455661(uc001lkc.1) ENST00000467366 ENST00000306042(uc001lkd.3 uc010quq.1)
    ENST00000487428 ENST00000495530 ENST00000479896 ENST00000492479 ENST00000463727
    ENST00000419012(uc010qup.1) ENST00000430713

    miRNA
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    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPRE (see all 65):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-3142 hsa-miR-383 hsa-miR-374b* hsa-miR-4306 hsa-miR-199a-5p hsa-miR-380
    SwitchGear 3'UTR luciferase reporter plasmid: PTPRE 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF406557.1 AJ315969.1 AK001335.1 AK026334.1 AK290414.1 AK291828.1 AK299498.1 AK300613.1 
    AL137560.1 BC031078.1 BC050062.1 BC071573.1 U36623.1 X54134.1 

    16 DOTS entries:

    DT.97839971  DT.100784200  DT.99961660  DT.40310129  DT.100784198  DT.91835333  DT.91751778  DT.92023650 
    DT.95177834  DT.446340  DT.92419875  DT.100731723  DT.121245004  DT.40106930  DT.86841032  DT.95368269 

    24/136 AceView cDNA sequences (see all 136):

    AW780325 BQ006544 Z43034 AI281507 BX477197 CD367614 BI768443 BQ003206 
    AI951353 BX117528 AW665303 R38478 BC071573 NM_006504 F02510 CA428275 
    BM725213 AK056111 X54134 CA310670 AF406557 NM_130435 BU159075 AI813430 

    GeneLoc Exon Structure


    Expression
    for PTPRE gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPRE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PTPRE expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primordial germ cell-like cells (Reconstitution of mo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PTPRE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPRE

    SOURCE GeneReport for Unigene cluster: Hs.127022

    UniProtKB/Swiss-Prot: PTPRE_HUMAN, P23469
    Tissue specificity: Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells)

        SABiosciences Expression via Pathway-Focused PCR Array including PTPRE: 
              Protein Phosphatases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRE

    Orthologs
    for PTPRE gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PTPRE gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PTPRE1 protein tyrosine phosphatase, receptor type, E 79.75(n)
    88.34(a)    		   423962  XM_421821.3  XP_421821.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PTPRE6
    		 --
    		 89(a)
    		 1 ↔ 1
    		 3(53986057-54007555)
    zebrafish
    (Danio rerio)    		 Actinopterygii ptprea1 protein tyrosine phosphatase, receptor type, E, a 72.58(n)
    77.05(a)    		   100499203  XM_003199651.1  XP_003199699.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 15(a)
    		 possible ortholog
    		 Group13.2(601038-605895)
    worm
    (Caenorhabditis elegans)    		 Secernentea T28F4.33 protein-tyrosine phosphatase 38(a)
    (best of 11)    		   I(7492238-7494102)   --


    ENSEMBL Gene Tree for PTPRE (if available)
    TreeFam Gene Tree for PTPRE (if available) 

    Paralogs
    for PTPRE gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPRE gene
    PTPRK2  PTPRC2  PTPRA2  PTPRG2  PTPRD2  PTPRS2  PTPRF2  PTPRM2  
    PTPRU2  PTPRZ12  PTPRT2  
    18/20 SIMAP similar genes for PTPRE using alignment to 6 protein entries:     PTPRE_HUMAN (see all proteins) (see all similar genes):
    PTPRA    PTPRD    DKFZp686B1310    DKFZp686C2268    PTPRS    PTPRK
    PTPsigma    PTPRF    LAR    PTPRT    PTPRC    PTPRM
    PTPRR    PTPN7    PTPRZ1    PTPRG    PTPRU    PTPN2

    PTPRE for paralogs           About GeneDecksing



    Genomic Variants
    for PTPRE gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3457 NCBI SNPs in PTPRE are shown (see all 3457)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1500563931,2
    		Cother123441188(+) ACCCCC/TATTGG 4 P syn11Minor allele frequency- T:0.00NA 4550
    rs779721931,2
    		F,--123278134(+) CCACCT/CCAACC 1 -- us2k11Minor allele frequency- C:0.09NA 120
    rs70984451,2
    		C,F,--123278195(+) GCTCCG/AAGGTG 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1154574991,2
    		C,F,--123278290(+) CTGACG/ATTGCT 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1135208721,2
    		--123278320(+) AAGCCA/CTGGAG 1 -- us2k12Minor allele frequency- C:0.03CSA WA 120
    rs794760311,2
    		F,--123278370(+) GGTAGG/AGGAAG 1 -- us2k11Minor allele frequency- A:0.09NA 120
    rs1117916401,2
    		--123278380(+) GAGGGC/GACGAC 1 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs124122641,2
    		C,H,--123278383(+) GGCACG/CACAGA 1 -- us2k13Minor allele frequency- C:0.09NA EA 242
    rs743875951,2
    		F,--123278856(+) GGGCCC/TTCTGG 1 -- us2k11Minor allele frequency- T:0.09NA 120
    rs770767091,2
    		F,--123279025(+) ACGGAT/CGGTGT 1 -- us2k11Minor allele frequency- C:0.10NA 120

    HapMap Linkage Disequilibrium report for PTPRE (129705325 - 129884180 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for PTPRE
         3 CNVs: 58425 71139 47892
         1 Indel: 71140

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPRE
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPRE

    Disorders / Diseases
    for PTPRE gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTPRE for disorders           About GeneDecksing

    OMIM gene information: 600926    OMIM disorders: --

    10 diseases for PTPRE:    About MalaCards
    ascending colon cancer    klatskin's tumor    giant cell tumor    rabies
    alzheimer's disease    colon cancer    breast cancer    asthma
    leukemia    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for PTPRE:
    Klatskin's tumor     Ascending colon cancer
    Human Genome Epidemiology (HuGE) Navigator: PTPRE (4 documents)

    Export disorders for PTPRE gene to outside databases

    Publications
    for PTPRE gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPRE gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with PTPRE)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. (PubMed id 8618876)1, 2, 9 Elson A. and Leder P. (1995)
    2. Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control. (PubMed id 10980613)1, 2, 9 Gil-Henn H....Elson A. (2000)
    3. Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization. (PubMed id 8595895)1, 3, 9 van den Maagdenberg A.M....Hendriks W.J. (1995)
    4. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)1, 2 Barr A.J.... Knapp S. (2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Expression of human protein tyrosine phosphatase epsilon in leucocytes: a potential ERK pathway-regulating phosphatase. (PubMed id 12121439)1, 2 Wabakken T.K.... Aasheim H.-C. (2002)
    8. Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate. (PubMed id 8610169)2, 7 Schmidt A.... Rodan G.A. (1996)
    9. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. (PubMed id 2170109)1, 2 Krueger N.X.... Saito H. (1990)
    10. The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. (PubMed id 8838320)1, 9 Elson A....Leder P. (1996)

    External Searches for PTPRE gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTPRE gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5791 HGNC: 9669 AceView: PTPRE Ensembl:ENSG00000132334 euGenes: HUgn5791
    ECgene: PTPRE H-InvDB: PTPRE

    Other Databases showing PTPRE gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTPRE gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPRE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPRE Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PTPRE gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTPRE gene:
    Search GeneIP for patents involving PTPRE

    Licensable Technologies for PTPRE gene:
    Weizmann Institute:Phophotyrosine Phosphatase - A Novel Target for Breast Cancer Therapy
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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