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PTPRE Gene

protein-coding   GIFtS: 68
GCID: GC10P129705

Protein Tyrosine Phosphatase, Receptor Type, E

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Receptor Type, E1 2     Protein Tyrosine Phosphatase, Receptor Type, Epsilon Polypeptide2
EC 3.1.3.483 8     Receptor-Type Tyrosine-Protein Phosphatase Epsilon2
HPTPE2     R-PTP-epsilon3
PTPE2     Protein-Tyrosine Phosphatase Epsilon3
R-PTP-EPSILON2     

External Ids:    HGNC: 96691   Entrez Gene: 57912   Ensembl: ENSG000001323347   OMIM: 6009265   UniProtKB: P234693   

Export aliases for PTPRE gene to outside databases

Previous GC identifers: GC10P128518 GC10P128746 GC10P129634 GC10P129179 GC10P129595 GC10P123280


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPRE Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been
reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single
transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains
a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the
similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways,
cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. (provided by RefSeq,
Jul 2008)

GeneCards Summary for PTPRE Gene:
PTPRE (protein tyrosine phosphatase, receptor type, E) is a protein-coding gene. Diseases associated with PTPRE include ascending colon cancer, and klatskin's tumor. GO annotations related to this gene include protein homodimerization activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRK.

UniProtKB/Swiss-Prot: PTPRE_HUMAN, P23469
Function: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology
in red blood cells. May play a role in osteoclast formation and function (By similarity)
Function: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates
insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1),
phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose
uptake (By similarity)
Function: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to
cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such
as phosphorylation of SLP76 and LAT and mobilization of Ca(2+) (By similarity)

Gene Wiki entry for PTPRE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPRE gene promoter:
         E2F-4   E2F-3a   E2F-5   Tal-1   Bach2   E2F-2   E47   E2F   E2F-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTPRE promoter sequence
   Search Chromatin IP Primers for PTPRE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPRE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.2   HGNC cytogenetic band: 10q26

PTPRE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRE gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P129705:  view genomic region     (about GC identifiers)

Start:
129,705,325 bp from pter      End:
129,884,180 bp from pter
Size:
178,856 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PTPRE_HUMAN, P23469 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein phosphatase epsilon precursor  
Size: 700 amino acids; 80642 Da
Subunit: Monomer. Isoform 2: Homodimer. Can form oligomers. Dimerization is increased by oxidative stress and
decreased by EGFR. Isoform 2 interacts with GRB2 (By similarity)
Sequence caution: Sequence=AAC50324.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the C-terminal part;
1 PDB 3D structure from and Proteopedia for PTPRE:
2JJD (3D)    
Secondary accessions: Q13345 Q5VWH3 Q5VWH4 Q96KQ6
Alternative promoter usage, Alternative initiation: 3 isoforms:  P23469-1   P23469-2   P23469-3   (Produced by alternative initiation at Met-86 of isoform 1)

Explore the universe of human proteins at neXtProt for PTPRE: NX_P23469

Explore proteomics data for PTPRE at MOPED

Post-translational modifications: 

  • A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2
    or isoform 31
  • Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu1
  • Isoform 1 is glycosylated1
  • Glycosylation2 at Asn23, Asn30
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTPRE (P23469) (see all 16)
     KCHQYWP  PIVVHCS  DYINASF  VVHCSAG 


    See PTPRE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006495.1  NP_569119.1  

    ENSEMBL proteins: 
     ENSP00000254667   ENSP00000410540   ENSP00000474102   ENSP00000416939   ENSP00000474830  
     ENSP00000303350   ENSP00000475063   ENSP00000473761   ENSP00000402337   ENSP00000413930  

    PTPRE Human Recombinant Protein Products:

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    Novus Biologicals PTPRE Proteins
    Novus Biologicals PTPRE Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for PTPRE

    PTPRE Antibody Products:

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    PTPRE Assay Products:

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    Cloud-Clone Corp. CLIAs for PTPRE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTPR: Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like

    IUPHAR Guide to PHARMACOLOGY protein family classification: Type E
    Receptor tyrosine phosphatases (RTP)

    4 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase
     IPR016336 Tyr_Pase_rcpt_a/e-type

    Graphical View of Domain Structure for InterPro Entry P23469

    ProtoNet protein and cluster: P23469

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTPRE_HUMAN, P23469
    Domain: The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the
    D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme
    activity (By similarity)
    Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily
    Similarity: Contains 2 tyrosine-protein phosphatase domains


    PTPRE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTPRE_HUMAN, P23469
    Function: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology
    in red blood cells. May play a role in osteoclast formation and function (By similarity)
    Function: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates
    insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1),
    phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose
    uptake (By similarity)
    Function: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to
    cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such
    as phosphorylation of SLP76 and LAT and mobilization of Ca(2+) (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Induction: Up-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) in HL-60 cells

         Genatlas biochemistry entry for PTPRE:
    protein tyrosine phosphatase,receptor-type IV,epsilon polypeptide

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0005001transmembrane receptor protein tyrosine phosphatase activity TAS2170109
    GO:0005515protein binding IPI10980613
    GO:0016791phosphatase activity ----
    GO:0042803protein homodimerization activity IEA--
         
    PTPRE for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PTPRE:
     Actin fiber cells  Decreased focal adhesion (FA)   Increased cell death in HCC-19  Increased cell death in breast 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ptpre):
     cellular  hematopoietic system  immune system  limbs/digits/tail  nervous system 
     skeleton 

    PTPRE for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptpretm1Ael for PTPRE

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTPRE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PTPRE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPRE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPRE

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTPRE:
    hsa-mir-335-5p (MIRT017960), hsa-mir-192-5p (MIRT026595), hsa-mir-215-5p (MIRT024574)

    Block miRNA regulation of human, mouse, rat PTPRE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPRE (see all 65):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-3142 hsa-miR-383 hsa-miR-374b* hsa-miR-4306 hsa-miR-199a-5p hsa-miR-380
    SwitchGear 3'UTR luciferase reporter plasmidPTPRE 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PTPRE
    Predesigned siRNA for gene silencing in human, mouse, rat PTPRE

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): PTPRE (NM_130435)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPRE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRE

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTPRE_HUMAN, P23469: Isoform 1: Cell membrane; Single-pass type I membrane protein
    PTPRE_HUMAN, P23469: Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated
    with nucleus and membrane. Insulin induces translocation to the membrane (By similarity)
    PTPRE_HUMAN, P23469: Isoform 3: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytoskeleton4
    endoplasmic reticulum3
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10980613
    GO:0005737cytoplasm IDA10980613
    GO:0005886plasma membrane IDA10980613
    GO:0016021integral component of membrane IEA--
    GO:0045111intermediate filament cytoskeleton ----

    PTPRE for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPRE About    
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2Signal transduction Erk Interactions Inhibition of Erk
    Signal transduction Erk Interactions Inhibition of Erk

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPRE
        Epithelial Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for PTPRE
        Signal transduction Erk Interactions- Inhibition of Erk


        Pathway & Disease-focused RT2 Profiler PCR Array including PTPRE: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPRE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for PTPRE (P234692, 3 ENSP000002546674) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8216985 I2D: score=4 STRING: ENSP00000357656
    KCNA5P224603, ENSP000002523214I2D: score=2 STRING: ENSP00000252321
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    PDGFRBP096193, ENSP000002617994I2D: score=1 STRING: ENSP00000261799
    PTPRDP234683, ENSP000003488124I2D: score=1 STRING: ENSP00000348812
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS2170109
    GO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway IEA--
    GO:0016311dephosphorylation ----
    GO:0033003regulation of mast cell activation IEA--
    GO:0035335peptidyl-tyrosine dephosphorylation ----

    PTPRE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPRE

    2 HMDB Compounds for PTPRE    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PTPRE    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AlendronateAcide Alendronique [INN-French] (see all 5)66376-36-1targetinhibitor8610169

    3 Novoseek inferred chemical compound relationships for PTPRE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 60.6 21 17486066 (2), 8618876 (2), 12460648 (2), 12193229 (2) (see all 14)
    potassium 41.4 2 17486066 (1)
    glycogen 27.4 1 17400802 (1)



    PTPRE for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PTPRE gene (2 alternative transcripts): 
    NM_006504.4  NM_130435.3  

    Unigene Cluster for PTPRE:

    Protein tyrosine phosphatase, receptor type, E
    Hs.127022  [show with all ESTs]
    Unigene Representative Sequence: NM_006504
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254667(uc001lkb.3 uc009yat.3 uc009yau.2) ENST00000442830
    ENST00000471218 ENST00000455661(uc001lkc.1) ENST00000467366 ENST00000306042(uc001lkd.3 uc010quq.1)
    ENST00000487428 ENST00000495530 ENST00000479896 ENST00000492479 ENST00000463727
    ENST00000419012(uc010qup.1) ENST00000430713

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    hsa-miR-300 hsa-miR-199a-3p hsa-miR-3142 hsa-miR-383 hsa-miR-374b* hsa-miR-4306 hsa-miR-199a-5p hsa-miR-380
    SwitchGear 3'UTR luciferase reporter plasmidPTPRE 3' UTR sequence
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat PTPRE

    Additional mRNA sequence: 

    AF406557.1 AJ315969.1 AK001335.1 AK026334.1 AK290414.1 AK291828.1 AK299498.1 AK300613.1 
    AL137560.1 BC031078.1 BC050062.1 BC071573.1 U36623.1 X54134.1 

    16 DOTS entries:

    DT.97839971  DT.100784200  DT.99961660  DT.40310129  DT.100784198  DT.91835333  DT.91751778  DT.92023650 
    DT.95177834  DT.446340  DT.92419875  DT.100731723  DT.121245004  DT.40106930  DT.86841032  DT.95368269 

    Selected AceView cDNA sequences (see all 136):

    Z38334 AI813430 BU159075 NM_130435 AF406557 CA310670 BM725213 CA428275 
    AK056111 X54134 AA362195 AL589399 NM_006504 BC071573 BI768443 AI951353 
    BQ003206 AW665303 BX117528 R38478 F02510 CD367614 BX477197 BQ006544 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPRE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTPRE Expression
    About this image


    PTPRE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Gonad
             Primordial Germ Cells Allantois
             Primordial germ cell-like cells
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PTPRE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPRE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127022

    UniProtKB/Swiss-Prot: PTPRE_HUMAN, P23469
    Tissue specificity: Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells)

        Pathway & Disease-focused RT2 Profiler PCR Array including PTPRE: 
              Protein Phosphatases in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat PTPRE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTPRE gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpre1 , 5 protein tyrosine phosphatase, receptor type, E1, 5 86.91(n)1
    93.12(a)1
      7 (81.27 cM)5
    192671  NM_011212.31  NP_035342.31 
     1355378245 
    chicken
    (Gallus gallus)
    Aves PTPRE1 protein tyrosine phosphatase, receptor type, E 77.47(n)
    84.79(a)
      423962  XM_421821.4  XP_421821.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ptpre1 protein tyrosine phosphatase, receptor type, E 76.75(n)
    85.67(a)
      100497631  XM_004912717.1  XP_004912774.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ptprea1 protein tyrosine phosphatase, receptor type, E, a 74.58(n)
    79.94(a)
      100499203  XM_005164315.1  XP_005164372.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T28F4.33 protein-tyrosine phosphatase 38(a)
    (best of 11)
      I(7492238-7494102)   --


    ENSEMBL Gene Tree for PTPRE (if available)
    TreeFam Gene Tree for PTPRE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPRE gene
    PTPRK2  PTPRC2  PTPRA2  PTPRG2  PTPRD2  PTPRS2  PTPRU2  PTPRM2  
    PTPRF2  PTPRT2  PTPRZ12  
    Selected SIMAP similar genes for PTPRE using alignment to 10 protein entries:     PTPRE_HUMAN (see all proteins) (see all similar genes):
    DKFZp313F1310    PTPRA    DKFZp781C1038    PTPRD    DKFZp686B1310    DKFZp686C2268
    PTPRS    PTPRK    PTPsigma    LAR    PTPRF    PTPRT
    PTPN7    PTPRM    PTPRC    PTPN5    PTPRR    PTPRZ1

    PTPRE for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPRE (see all 4073)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500563931,2
    Cuntested1130353175(+) ACCCCC/TATTGG 4 P syn11Minor allele frequency- T:0.00NA 4550
    rs723238481,2
    C--123355532(+) TTTGC-/GTGTGTG 1 -- int10--------
    rs679686831,2
    C--123366741(+) AGTGG-/GTTGTGT 1 -- int10--------
    rs599220761,2
    C--123366759(+) GTGTG-/TG    
       
    /TGTG
    CGTGT
    1 -- int10--------
    rs1467454831,2
    --123368814(+) ACACA-/CACACAC
    ACACACACG
    CACGC
    1 -- int10--------
    rs590079801,2
    C--123375691(+) TTTTT-/T/TTTT
    TTTTTTTT
    GAGAC
    2 -- int1 cds11NA 2
    rs352334821,2
    C,F--123405990(+) AATTTG/-TAATT 1 -- int14Minor allele frequency- -:0.38NA CSA 8
    rs719451661,2
    C--123432921(+) CATGC-/CAACACA 2 -- int10--------
    rs1422432031,2
    C--123440177(+) CACAC-/ATACACC 2 -- int10--------
    rs579350681,2
    C--123440178(+) ACACA-/TACACCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for PTPRE (129705325 - 129884180 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PTPRE:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671595CNV Deletion23128226
    esv2743306CNV Deletion23290073
    esv2743317CNV Deletion23290073
    esv2743328CNV Deletion23290073
    esv26786CNV Loss19812545
    esv34105CNV Loss18971310
    nsv832020CNV Gain17160897
    nsv819343CNV Gain19587683
    esv23475CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTPRE
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPRE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600926    OMIM disorders: --

    10 diseases for PTPRE:    
    About MalaCards
    ascending colon cancer    klatskin's tumor    giant cell tumor    rabies
    asthma    alzheimer's disease    endotheliitis    leukemia
    breast cancer    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for PTPRE:
    Klatskin's tumor     Ascending colon cancer

    PTPRE for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): PTPRE
    Human Genome Epidemiology (HuGE) Navigator: PTPRE (4 documents)

    Export disorders for PTPRE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPRE gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with PTPRE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. (PubMed id 8618876)1, 2, 9 Elson A. and Leder P. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control. (PubMed id 10980613)1, 2, 9 Gil-Henn H....Elson A. (Oncogene 2000)
    3. Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization. (PubMed id 8595895)1, 3, 9 van den Maagdenberg A.M....Hendriks W.J. (Genomics 1995)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    6. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)1, 2 Barr A.J.... Knapp S. (Cell 2009)
    7. Genes to diseases (G2D) computational method to identify asthma candidate genes. (PubMed id 18682798)1, 4 Tremblay K....Laprise C. (PLoS ONE 2008)
    8. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)1, 4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    9. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5791 HGNC: 9669 AceView: PTPRE Ensembl:ENSG00000132334 euGenes: HUgn5791
    ECgene: PTPRE H-InvDB: PTPRE

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPRE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPRE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPRE gene:
    Search GeneIP for patents involving PTPRE

    Licensable Technologies for PTPRE gene:
    Weizmann Institute:Phophotyrosine Phosphatase - A Novel Target for Breast Cancer Therapy
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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