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Aliases for PTPRE Gene

Aliases for PTPRE Gene

  • Protein Tyrosine Phosphatase, Receptor Type, E 2 3
  • R-PTP-EPSILON 3 4
  • EC 3.1.3.48 4 64
  • Protein Tyrosine Phosphatase, Receptor Type, Epsilon Polypeptide 3
  • Receptor-Type Tyrosine-Protein Phosphatase Epsilon 3
  • Protein-Tyrosine Phosphatase Epsilon 4
  • HPTPE 3
  • PTPE 3

External Ids for PTPRE Gene

Summaries for PTPRE Gene

Entrez Gene Summary for PTPRE Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRE Gene

PTPRE (Protein Tyrosine Phosphatase, Receptor Type, E) is a Protein Coding gene. Diseases associated with PTPRE include ascending colon cancer. Among its related pathways are PAK Pathway and Signal transduction_Erk Interactions- Inhibition of Erk. GO annotations related to this gene include protein homodimerization activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRT.

UniProtKB/Swiss-Prot for PTPRE Gene

  • Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).

  • Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity).

  • Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).

Gene Wiki entry for PTPRE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRE Gene

Genomics for PTPRE Gene

Genomic Location for PTPRE Gene

Start:
127,907,061 bp from pter
End:
128,085,916 bp from pter
Size:
178,856 bases
Orientation:
Plus strand

Genomic View for PTPRE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRE Gene

Regulatory Elements for PTPRE Gene

Proteins for PTPRE Gene

  • Protein details for PTPRE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23469-PTPRE_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase epsilon
    Protein Accession:
    P23469
    Secondary Accessions:
    • Q13345
    • Q5VWH3
    • Q5VWH4
    • Q96KQ6

    Protein attributes for PTPRE Gene

    Size:
    700 amino acids
    Molecular mass:
    80642 Da
    Quaternary structure:
    • Monomer. Isoform 2: Homodimer. Can form oligomers. Dimerization is increased by oxidative stress and decreased by EGFR. Isoform 2 interacts with GRB2 (By similarity).
    SequenceCaution:
    • Sequence=AAC50324.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRE Gene

    Alternative splice isoforms for PTPRE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRE Gene

Proteomics data for PTPRE Gene at MOPED

Post-translational modifications for PTPRE Gene

  • A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3.
  • Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu.
  • Isoform 1 is glycosylated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn23 and Asn30

Domains for PTPRE Gene

Gene Families for PTPRE Gene

HGNC:
  • PTPR :Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like
IUPHAR :

UniProtKB/Swiss-Prot:

PTPRE_HUMAN
Domain:
  • The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity (By similarity).:
    • P23469
  • Contains 2 tyrosine-protein phosphatase domains.:
    • P23469
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.:
    • P23469
genes like me logo Genes that share domains with PTPRE: view

Function for PTPRE Gene

Molecular function for PTPRE Gene

GENATLAS Biochemistry: protein tyrosine phosphatase,receptor-type IV,epsilon polypeptide
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).
UniProtKB/Swiss-Prot Function: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity).
UniProtKB/Swiss-Prot Function: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
UniProtKB/Swiss-Prot Induction: Up-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) in HL-60 cells.

Enzyme Numbers (IUBMB) for PTPRE Gene

Gene Ontology (GO) - Molecular Function for PTPRE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity --
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 2170109
GO:0005515 protein binding IPI 10980613
GO:0016791 phosphatase activity --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with PTPRE: view
genes like me logo Genes that share phenotypes with PTPRE: view

Animal Models for PTPRE Gene

MGI Knock Outs for PTPRE:

miRNA for PTPRE Gene

miRTarBase miRNAs that target PTPRE

No data available for Transcription Factor Targeting and HOMER Transcription for PTPRE Gene

Localization for PTPRE Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRE Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity). {ECO:0000250}.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRE Gene COMPARTMENTS Subcellular localization image for PTPRE gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytoskeleton 4
endoplasmic reticulum 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10980613
GO:0005737 cytoplasm IDA 10980613
GO:0005886 plasma membrane IDA 10980613
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTPRE: view

Pathways for PTPRE Gene

genes like me logo Genes that share pathways with PTPRE: view

Pathways by source for PTPRE Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for PTPRE Gene
1 Qiagen pathway for PTPRE Gene

Gene Ontology (GO) - Biological Process for PTPRE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 2170109
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway IEA --
GO:0016311 dephosphorylation --
GO:0033003 regulation of mast cell activation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 2170109
genes like me logo Genes that share ontologies with PTPRE: view

Compounds for PTPRE Gene

(2) HMDB Compounds for PTPRE Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(1) Drugbank Compounds for PTPRE Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alendronate
  • Acide Alendronique [INN-French]
66376-36-1 target inhibitor

(3) Novoseek inferred chemical compound relationships for PTPRE Gene

Compound -log(P) Hits PubMed IDs
tyrosine 60.6 19
potassium 41.4 1
glycogen 27.4 1
genes like me logo Genes that share compounds with PTPRE: view

Transcripts for PTPRE Gene

Unigene Clusters for PTPRE Gene

Protein tyrosine phosphatase, receptor type, E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRE Gene

No ASD Table

Relevant External Links for PTPRE Gene

GeneLoc Exon Structure for
PTPRE
ECgene alternative splicing isoforms for
PTPRE

Expression for PTPRE Gene

mRNA expression in normal human tissues for PTPRE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRE Gene

This gene is overexpressed in Whole Blood (12.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRE Gene

SOURCE GeneReport for Unigene cluster for PTPRE Gene Hs.127022

mRNA Expression by UniProt/SwissProt for PTPRE Gene

P23469-PTPRE_HUMAN
Tissue specificity: Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells).
genes like me logo Genes that share expressions with PTPRE: view

Orthologs for PTPRE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPRE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRE 36
  • 99.67 (n)
  • 99.71 (a)
PTPRE 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRE 36
  • 88.33 (n)
  • 93.43 (a)
PTPRE 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRE 36
  • 90.56 (n)
  • 94.85 (a)
PTPRE 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpre 36
  • 86.91 (n)
  • 93.12 (a)
Ptpre 16
Ptpre 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPRE 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpre 36
  • 86.77 (n)
  • 93.12 (a)
chicken
(Gallus gallus)
Aves PTPRE 36
  • 77.47 (n)
  • 84.79 (a)
PTPRE 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpre 36
  • 76.75 (n)
  • 85.67 (a)
zebrafish
(Danio rerio)
Actinopterygii ptprea 36
  • 74.58 (n)
  • 79.94 (a)
ptprea 37
  • 76 (a)
OneToMany
ptpreb 37
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ptp69D 38
  • 34 (a)
Ptp52F 38
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea ptp-3 37
  • 12 (a)
OneToMany
T28F4.3 38
  • 38 (a)
ZK616.7 38
  • 35 (a)
F25H5.7 38
  • 31 (a)
F47B3.6 38
  • 32 (a)
K07F5.8 38
  • 33 (a)
T27A3.5 38
  • 34 (a)
T22C1.8 38
  • 33 (a)
F47B3.1 38
  • 32 (a)
M04G7.2 38
  • 34 (a)
F55F8.7 38
  • 31 (a)
Y48G9A.9 38
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTP2 39
Species with no ortholog for PTPRE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRE Gene

ENSEMBL:
Gene Tree for PTPRE (if available)
TreeFam:
Gene Tree for PTPRE (if available)

Paralogs for PTPRE Gene

Paralogs for PTPRE Gene

genes like me logo Genes that share paralogs with PTPRE: view

Variants for PTPRE Gene

Sequence variations from dbSNP and Humsavar for PTPRE Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs6911 -- 128,085,669(-) CATAA(A/G)TTAAA utr-variant-3-prime
rs747715 -- 127,962,349(-) GGGGC(A/C)TTGAG intron-variant
rs747716 -- 127,961,628(+) ATAAG(C/T)GCTCC intron-variant
rs913287 -- 127,920,414(+) GTGGG(C/T)GTGTG intron-variant
rs913288 -- 127,977,520(-) CTTAA(A/G)GCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRE Gene

Variant ID Type Subtype PubMed ID
nsv832020 CNV Gain 17160897
esv2743306 CNV Deletion 23290073
esv2743317 CNV Deletion 23290073
esv2671595 CNV Deletion 23128226
esv2743328 CNV Deletion 23290073
esv26786 CNV Loss 19812545
esv34105 CNV Loss 18971310
nsv819343 CNV Gain 19587683
esv23475 CNV Gain 19812545

Relevant External Links for PTPRE Gene

HapMap Linkage Disequilibrium report
PTPRE

Disorders for PTPRE Gene

(1) MalaCards Diseases for PTPRE Gene

Search for PTPRE Gene in MalaCards »

(2) University of Copenhagen DISEASES for PTPRE Gene

Relevant External Links for PTPRE

Genetic Association Database (GAD)
PTPRE
Human Genome Epidemiology (HuGE) Navigator
PTPRE
genes like me logo Genes that share disorders with PTPRE: view

No data available for UniProtKB/Swiss-Prot for PTPRE Gene

Publications for PTPRE Gene

  1. Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization. (PMID: 8595895) van den Maagdenberg A.M. … Hendriks W.J. (Genomics 1995) 2 3 23
  2. Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. (PMID: 8618876) Elson A. … Leder P. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4 23
  3. Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control. (PMID: 10980613) Gil-Henn H. … Elson A. (Oncogene 2000) 3 4 23
  4. The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. (PMID: 8838320) Elson A. … Leder P. (Genomics 1996) 3 23
  5. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. (PMID: 2170109) Krueger N.X. … Saito H. (EMBO J. 1990) 3 4

Products for PTPRE Gene

  • Addgene plasmids for PTPRE

Sources for PTPRE Gene

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