Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PTPRD Gene

Aliases for PTPRD Gene

  • Protein Tyrosine Phosphatase, Receptor Type D 2 3
  • Protein Tyrosine Phosphatase, Receptor Type, D 3 5
  • R-PTP-Delta 3 4
  • EC 4 63
  • Protein Tyrosine Phosphatase, Receptor Type, Delta Polypeptide 3
  • Protein-Tyrosine Phosphatase Delta 4
  • HPTPD 3
  • HPTP 3
  • PTPD 3

External Ids for PTPRD Gene

Previous GeneCards Identifiers for PTPRD Gene

  • GC09M008470
  • GC09M008298

Summaries for PTPRD Gene

Entrez Gene Summary for PTPRD Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]

GeneCards Summary for PTPRD Gene

PTPRD (Protein Tyrosine Phosphatase, Receptor Type D) is a Protein Coding gene. Diseases associated with PTPRD include Cough Headache and Restless Legs Syndrome. Among its related pathways are Transmission across Chemical Synapses and PAK Pathway. GO annotations related to this gene include receptor binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRK.

Gene Wiki entry for PTPRD Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRD Gene

Genomics for PTPRD Gene

Regulatory Elements for PTPRD Gene

Enhancers for PTPRD Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTPRD on UCSC Golden Path with GeneCards custom track

Promoters for PTPRD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTPRD on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPRD Gene

8,314,246 bp from pter
10,612,723 bp from pter
2,298,478 bases
Minus strand

Genomic View for PTPRD Gene

Genes around PTPRD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRD Gene

Proteins for PTPRD Gene

  • Protein details for PTPRD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-type tyrosine-protein phosphatase delta
    Protein Accession:
    Secondary Accessions:
    • B1ALA0
    • F5GWT7
    • Q3KPJ0
    • Q3KPJ1
    • Q3KPJ2

    Protein attributes for PTPRD Gene

    1912 amino acids
    Molecular mass:
    214760 Da
    Quaternary structure:
    • Interacts with IL1RAPL1 (via extracellular region); interaction is required for IL1RAPL1-mediated synapse formation (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3.

    Three dimensional structures from OCA and Proteopedia for PTPRD Gene

    Alternative splice isoforms for PTPRD Gene

neXtProt entry for PTPRD Gene

Proteomics data for PTPRD Gene at MOPED

Post-translational modifications for PTPRD Gene

  • A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called ectodomain shedding is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.
  • Glycosylation at Asn 254, Asn 299, Asn 724, and Asn 832
  • Modification sites at PhosphoSitePlus

Domains & Families for PTPRD Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
  • Contains 8 fibronectin type-III domains.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 tyrosine-protein phosphatase domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
genes like me logo Genes that share domains with PTPRD: view

Function for PTPRD Gene

Molecular function for PTPRD Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type II,delta polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

Enzyme Numbers (IUBMB) for PTPRD Gene

genes like me logo Genes that share phenotypes with PTPRD: view

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTPRD Gene

Localization for PTPRD Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRD Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PTPRD Gene COMPARTMENTS Subcellular localization image for PTPRD gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PTPRD Gene

Pathways & Interactions for PTPRD Gene

genes like me logo Genes that share pathways with PTPRD: view

Pathways by source for PTPRD Gene

2 Reactome pathways for PTPRD Gene
1 Qiagen pathway for PTPRD Gene

SIGNOR curated interactions for PTPRD Gene


Gene Ontology (GO) - Biological Process for PTPRD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,TAS 7896816
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway TAS 7896816
GO:0035335 peptidyl-tyrosine dephosphorylation IEA,TAS 7896816
GO:0097105 presynaptic membrane assembly ISS --
genes like me logo Genes that share ontologies with PTPRD: view

Drugs & Compounds for PTPRD Gene

(3) Drugs for PTPRD Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Trandolapril Approved Pharma 21
Verapamil Approved Pharma Channel blocker 122

(3) Additional Compounds for PTPRD Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with PTPRD: view

Transcripts for PTPRD Gene

mRNA/cDNA for PTPRD Gene

(36) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTPRD Gene

Protein tyrosine phosphatase, receptor type, D:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRD Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - - -
SP2: - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b

Relevant External Links for PTPRD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPRD Gene

mRNA expression in normal human tissues for PTPRD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRD Gene

This gene is overexpressed in Brain - Cerebellum (x4.9), Brain - Cerebellar Hemisphere (x4.9), and Brain - Spinal cord (cervical c-1) (x4.8).

Protein differential expression in normal tissues from HIPED for PTPRD Gene

This gene is overexpressed in Cerebrospinal fluid (30.9), Fetal Brain (11.6), Brain (7.4), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTPRD Gene

SOURCE GeneReport for Unigene cluster for PTPRD Gene Hs.446083

genes like me logo Genes that share expression patterns with PTPRD: view

Protein tissue co-expression partners for PTPRD Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PTPRD Gene

Orthologs for PTPRD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PTPRD Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PTPRD 35
  • 93.53 (n)
  • 98.12 (a)
  • 99 (a)
(Canis familiaris)
Mammalia PTPRD 35
  • 94.18 (n)
  • 98.54 (a)
  • 99 (a)
(Pan troglodytes)
Mammalia PTPRD 35
  • 99.56 (n)
  • 99.84 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ptprd 35
  • 91.9 (n)
  • 98.15 (a)
(Monodelphis domestica)
Mammalia PTPRD 36
  • 97 (a)
(Mus musculus)
Mammalia Ptprd 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia PTPRD 36
  • 97 (a)
(Gallus gallus)
Aves PTPRD 35
  • 85.11 (n)
  • 94.55 (a)
  • 92 (a)
(Anolis carolinensis)
Reptilia PTPRD 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2212 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21031 35
(Danio rerio)
Actinopterygii ptprdb 35
  • 64.64 (n)
  • 67.82 (a)
ptprdb 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lar 37
  • 40 (a)
Ptp69D 37
  • 35 (a)
Lar 35
  • 53.04 (n)
  • 51.29 (a)
Lar 36
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010090 35
  • 31.74 (n)
  • 15.06 (a)
(Caenorhabditis elegans)
Secernentea F25H5.7 37
  • 35 (a)
K04D7.4 37
  • 33 (a)
Y48G9A.9 37
  • 34 (a)
ptp-3 35
  • 59.52 (n)
  • 59.17 (a)
(Triticum aestivum)
Liliopsida Ta.1188 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1998 36
  • 46 (a)
Species with no ortholog for PTPRD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PTPRD Gene

Gene Tree for PTPRD (if available)
Gene Tree for PTPRD (if available)

Paralogs for PTPRD Gene

Paralogs for PTPRD Gene Pseudogenes for PTPRD Gene

genes like me logo Genes that share paralogs with PTPRD: view

Variants for PTPRD Gene

Sequence variations from dbSNP and Humsavar for PTPRD Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10977171 - 8,518,052(+) GATCT(C/G)TCCAT reference, missense
VAR_035645 A colorectal cancer sample
VAR_035646 A colorectal cancer sample
VAR_035647 A colorectal cancer sample
rs7869444 - 8,484,298(+) GATTT(A/C/G)TCAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PTPRD Gene

Variant ID Type Subtype PubMed ID
nsv524896 CNV Gain 19592680
nsv8414 CNV Loss 18304495
nsv892223 CNV Loss 21882294
nsv892224 CNV Gain 21882294
nsv523768 CNV Loss 19592680
esv26678 CNV Gain 19812545
esv996283 CNV Insertion 20482838
esv1314470 CNV Insertion 17803354
nsv892225 CNV Gain 21882294
nsv526971 CNV Loss 19592680
nsv892226 CNV Gain 21882294
nsv892227 CNV Gain 21882294
nsv527205 CNV Loss 19592680
nsv892228 CNV Gain 21882294
esv1005977 CNV Insertion 20482838
esv1627386 CNV Insertion 17803354
nsv892229 CNV Loss 21882294
nsv831504 CNV Loss 17160897
esv2660314 CNV Deletion 23128226
nsv528895 CNV Loss 19592680
nsv528345 CNV Loss 19592680
esv7107 CNV Gain 19470904
nsv892230 CNV Gain 21882294
nsv892231 CNV Loss 21882294
nsv442133 CNV CNV 18776908
dgv1210n67 CNV Loss 20364138
esv2661630 CNV Deletion 23128226
esv2738182 CNV Deletion 23290073
esv29008 CNV Loss 19812545
nsv892233 CNV Gain 21882294
dgv8030n71 CNV Loss 21882294
esv273131 CNV Insertion 20981092
esv268174 CNV Insertion 20981092
esv2675531 CNV Deletion 23128226
nsv824846 CNV Loss 20364138
dgv8031n71 CNV Gain 21882294
nsv6474 CNV Loss 18451855
dgv8032n71 CNV Loss 21882294
nsv892239 CNV Gain 21882294
esv2738183 CNV Deletion 23290073
esv2311235 CNV Deletion 18987734
esv2738185 CNV Deletion 23290073
esv2738186 CNV Deletion 23290073
esv1043147 CNV Deletion 17803354
nsv466124 CNV Loss 19166990
nsv892240 CNV Gain 21882294
nsv524721 CNV Loss 19592680
nsv892241 CNV Loss 21882294
nsv528774 CNV Loss 19592680
nsv525293 CNV Loss 19592680
esv3052 CNV Deletion 18987735
esv2738187 CNV Deletion 23290073
esv2667270 CNV Deletion 23128226
esv2677386 CNV Deletion 23128226
esv2738188 CNV Deletion 23290073
nsv522121 CNV Loss 19592680
nsv819452 CNV Gain 19587683
nsv892242 CNV Gain 21882294
esv26819 CNV Loss 19812545
nsv892243 CNV Loss 21882294
nsv892244 CNV Loss 21882294
esv2677798 CNV Deletion 23128226
esv2185581 CNV Deletion 18987734
nsv892245 CNV Gain 21882294
esv2663067 CNV Deletion 23128226
nsv892246 CNV Gain 21882294
esv1535970 CNV Insertion 17803354
nsv415985 CNV Loss 16902084
nsv471275 CNV Loss 18288195
esv273815 CNV Insertion 20981092
nsv892247 CNV Loss 21882294
nsv466128 CNV Loss 19166990
nsv509295 CNV Insertion 20534489
esv2667480 CNV Deletion 23128226
nsv6475 CNV Insertion 18451855
esv1163845 CNV Insertion 17803354
esv999794 CNV Insertion 20482838
nsv519716 CNV Loss 19592680
nsv892248 CNV Gain 21882294
nsv892249 CNV Gain 21882294
nsv892250 CNV Gain 21882294
nsv831505 CNV Gain 17160897
nsv892251 CNV Loss 21882294
nsv517639 CNV Loss 19592680
nsv518679 CNV Loss 19592680
esv2738189 CNV Deletion 23290073
nsv892252 CNV Gain 21882294
nsv519001 CNV Loss 19592680
nsv520273 CNV Loss 19592680
esv2671017 CNV Deletion 23128226
nsv892253 CNV Loss 21882294
dgv8033n71 CNV Loss 21882294
nsv824847 CNV Loss 20364138
nsv466129 CNV Loss 19166990
esv2738190 CNV Deletion 23290073
dgv8034n71 CNV Loss 21882294
nsv892258 CNV Loss 21882294
nsv818683 CNV Gain 17921354
nsv520832 CNV Loss 19592680
nsv524993 CNV Gain 19592680
esv27358 CNV Loss 19812545
nsv892260 CNV Loss 21882294
nsv892261 CNV Loss 21882294
nsv892262 CNV Loss 21882294
nsv466130 CNV Loss 19166990
esv2671051 CNV Deletion 23128226
nsv6477 CNV Insertion 18451855
nsv892263 CNV Loss 21882294
nsv528425 CNV Loss 19592680
dgv8035n71 CNV Gain 21882294
dgv477n21 CNV Loss 19592680
nsv892266 CNV Loss 21882294
nsv466131 CNV Loss 19166990
nsv892267 CNV Loss 21882294
nsv824848 CNV Loss 20364138
esv2660872 CNV Deletion 23128226
esv24167 CNV Loss 19812545
nsv892268 CNV Gain 21882294
nsv892269 CNV Loss 21882294
nsv892270 CNV Gain 21882294
esv2663894 CNV Deletion 23128226
esv2422381 CNV Deletion 17116639
dgv8036n71 CNV Loss 21882294
nsv527763 CNV Loss 19592680
nsv892274 CNV Loss 21882294
esv2666810 CNV Deletion 23128226
esv2556521 CNV Deletion 19546169
nsv526471 CNV Loss 19592680
esv2445912 CNV Deletion 19546169
nsv892275 CNV Loss 21882294
dgv8037n71 CNV Loss 21882294
nsv471276 CNV Loss 18288195
dgv8038n71 CNV Loss 21882294
dgv8039n71 CNV Loss 21882294
nsv892284 CNV Loss 21882294
dgv8040n71 CNV Loss 21882294
dgv8041n71 CNV Loss 21882294
dgv2281e1 CNV Complex 17122850
nsv437081 CNV Loss 16327808
nsv518851 CNV Loss 19592680
nsv892290 CNV Loss 21882294
nsv438091 CNV Loss 16468122
nsv892291 CNV Loss 21882294
nsv466144 CNV Loss 19166990
nsv507503 CNV Insertion 20534489
nsv466145 CNV Loss 19166990
esv27909 CNV Loss 19812545
dgv8042n71 CNV Loss 21882294
nsv892295 CNV Gain 21882294
esv1229085 CNV Deletion 17803354
esv2738191 CNV Deletion 23290073
esv2738192 CNV Deletion 23290073
esv2738193 CNV Deletion 23290073
nsv892296 CNV Loss 21882294
nsv466147 CNV Loss 19166990
esv2752311 CNV Loss 17911159
esv270476 CNV Insertion 20981092
esv274211 CNV Insertion 20981092
nsv528854 CNV Loss 19592680
esv2738194 CNV Deletion 23290073
nsv524955 CNV Loss 19592680
nsv892297 CNV Gain 21882294
esv2657840 CNV Deletion 23128226
nsv892298 CNV Gain 21882294
nsv471277 CNV Loss 18288195
esv2665825 CNV Deletion 23128226
nsv466148 CNV Loss 19166990
nsv519026 CNV Loss 19592680
nsv892299 CNV Loss 21882294
nsv466150 CNV Loss 19166990
esv2494179 CNV Deletion 19546169
esv1932426 CNV Deletion 18987734
esv3933 CNV Deletion 18987735
esv2738196 CNV Deletion 23290073
nsv416942 CNV Loss 16902084
esv6560 CNV Loss 19470904
dgv915n27 CNV Loss 19166990
nsv471278 CNV Loss 18288195
dgv478n21 CNV Loss 19592680
esv2427201 CNV Deletion 19546169
nsv892300 CNV Loss 21882294
nsv466153 CNV Loss 19166990
dgv2282e1 CNV Complex 17122850
nsv824849 CNV Loss 20364138
esv2669282 CNV Deletion 23128226
nsv818684 CNV Loss 17921354
dgv8043n71 CNV Gain 21882294
nsv466155 CNV Gain 19166990
esv25218 CNV Gain 19812545
nsv820396 CNV Deletion 20802225
nsv512088 CNV Loss 21212237
esv1538552 CNV Deletion 17803354
nsv831506 CNV Gain 17160897
nsv892303 CNV Loss 21882294
nsv824850 CNV Loss 20364138
esv28382 CNV Loss 19812545
dgv8044n71 CNV Loss 21882294
nsv892306 CNV Gain 21882294
nsv471279 CNV Loss 18288195
nsv466156 CNV Loss 19166990
nsv892307 CNV Loss 21882294
nsv510180 CNV Loss 20534489
nsv466157 CNV Loss 19166990
nsv507504 CNV Insertion 20534489
nsv512089 CNV Loss 21212237
esv2114231 CNV Deletion 18987734
esv2640344 CNV Deletion 19546169
esv2738197 CNV Deletion 23290073
esv4443 CNV Deletion 18987735
esv9310 CNV Loss 19470904
esv2667750 CNV Deletion 23128226
nsv892308 CNV Loss 21882294
nsv892309 CNV Loss 21882294
nsv471280 CNV Gain 18288195
nsv466158 CNV Gain 19166990
nsv416572 CNV Loss 16902084
dgv2283e1 CNV Complex 17122850
nsv892310 CNV Gain 21882294
nsv416854 CNV Loss 16902084
nsv892311 CNV Loss 21882294
nsv892312 CNV Gain 21882294
esv2738198 CNV Deletion 23290073
nsv892313 CNV Loss 21882294
nsv892314 CNV Loss 21882294
nsv516073 CNV Gain+Loss 19592680
nsv892315 CNV Gain 21882294
nsv466159 CNV Loss 19166990
nsv892316 CNV Gain 21882294
esv2661178 CNV Deletion 23128226
nsv466161 CNV Loss 19166990
esv2435626 CNV Insertion 19546169
nsv466162 CNV Loss 19166990
nsv6478 CNV Loss 18451855
esv2531598 CNV Deletion 19546169
nsv511420 CNV Loss 21212237
esv2223141 CNV Deletion 18987734
esv3226 CNV Deletion 18987735
dgv1211n67 CNV Loss 20364138
nsv821534 CNV Deletion 20802225
esv2738199 CNV Deletion 23290073
esv2671660 CNV Deletion 23128226
esv1010369 CNV Deletion 20482838
nsv415375 CNV Loss 16902084
esv7310 CNV Loss 19470904
esv1766329 CNV Deletion 17803354
esv23663 CNV Gain 19812545
nsv892317 CNV Gain 21882294
nsv831507 CNV Loss 17160897
esv2672296 CNV Deletion 23128226
esv273437 CNV Insertion 20981092
esv269281 CNV Insertion 20981092
esv1082326 CNV Insertion 17803354
nsv892318 CNV Gain 21882294
nsv466163 CNV Gain 19166990
nsv526611 CNV Gain 19592680
nsv521326 CNV Loss 19592680
nsv892319 CNV Loss 21882294
nsv466164 CNV Loss 19166990
esv2409256 CNV Deletion 18987734
esv4583 CNV Deletion 18987735
esv2738200 CNV Deletion 23290073
nsv415727 CNV Loss 16902084
esv1001856 CNV Deletion 20482838
esv1585677 CNV Deletion 17803354
esv6672 CNV Loss 19470904
dgv8045n71 CNV Loss 21882294
esv34558 CNV Loss 17911159
dgv2284e1 CNV Complex 17122850
dgv479n21 CNV Loss 19592680
nsv892322 CNV Loss 21882294
nsv437082 CNV Loss 16327808
nsv442134 CNV CNV 18776908
nsv892323 CNV Gain 21882294
essv17415 CNV CNV 17122850
esv34992 CNV Loss 17911159
dgv916n27 CNV Loss 19166990
nsv438092 CNV Loss 16468122
nsv892324 CNV Loss 21882294
nsv437083 CNV Loss 16327808
nsv892325 CNV Loss 21882294
nsv437084 CNV Loss 16327808
nsv466167 CNV Loss 19166990
nsv831508 CNV Gain 17160897
nsv892326 CNV Loss 21882294

Variation tolerance for PTPRD Gene

Residual Variation Intolerance Score: 0.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.32; 81.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRD Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRD Gene

Disorders for PTPRD Gene

MalaCards: The human disease database

(2) MalaCards diseases for PTPRD Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cough headache
  • primary cough headache
restless legs syndrome
  • wed
- elite association - COSMIC cancer census association via MalaCards
Search PTPRD in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPRD

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PTPRD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRD Gene

Publications for PTPRD Gene

  1. Molecular characterization of the human transmembrane protein- tyrosine phosphatase delta. Evidence for tissue-specific expression of alternative human transmembrane protein-tyrosine phosphatase delta isoforms. (PMID: 7896816) Pulido R. … Streuli M. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation. (PMID: 20139422) Kwon S.K. … Kim E. (J. Biol. Chem. 2010) 3 23
  3. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. (PMID: 20174558) Tsai F.J. … Wu J.Y. (PLoS Genet. 2010) 3 23
  4. The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. (PMID: 19478061) Veeriah S. … Chan T.A. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  5. Aberrant splicing of the PTPRD gene mimics microdeletions identified at this locus in neuroblastomas. (PMID: 18050303) Nair P. … Stallings R.L. (Genes Chromosomes Cancer 2008) 3 23

Products for PTPRD Gene

Sources for PTPRD Gene