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Aliases for PTPRCAP Gene

Aliases for PTPRCAP Gene

  • Protein Tyrosine Phosphatase, Receptor Type, C-Associated Protein 2 3
  • Lymphocyte Phosphatase-Associated Phosphoprotein 3 4
  • PTPRC-Associated Protein 3 4
  • CD45-Associated Protein 3 4
  • CD45-AP 3 4
  • LPAP 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide-Associated Protein 3
  • CD45 Associated Protein 3

External Ids for PTPRCAP Gene

Previous GeneCards Identifiers for PTPRCAP Gene

  • GC11P069666
  • GC11M068899
  • GC11M066978
  • GC11M066959
  • GC11M067202
  • GC11M063531

Summaries for PTPRCAP Gene

Entrez Gene Summary for PTPRCAP Gene

  • The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRCAP Gene

PTPRCAP (Protein Tyrosine Phosphatase, Receptor Type, C-Associated Protein) is a Protein Coding gene.

Gene Wiki entry for PTPRCAP Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRCAP Gene

Genomics for PTPRCAP Gene

Regulatory Elements for PTPRCAP Gene

Genomic Location for PTPRCAP Gene

Chromosome:
11
Start:
67,435,510 bp from pter
End:
67,438,067 bp from pter
Size:
2,558 bases
Orientation:
Minus strand

Genomic View for PTPRCAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for PTPRCAP Gene

Proteins for PTPRCAP Gene

  • Protein details for PTPRCAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14761-PTCA_HUMAN
    Recommended name:
    Protein tyrosine phosphatase receptor type C-associated protein
    Protein Accession:
    Q14761
    Secondary Accessions:
    • B2R512
    • O00643
    • Q6I9S6

    Protein attributes for PTPRCAP Gene

    Size:
    206 amino acids
    Molecular mass:
    21196 Da
    Quaternary structure:
    • Interacts with CD45/PTPRC.

neXtProt entry for PTPRCAP Gene

Proteomics data for PTPRCAP Gene at MOPED

Post-translational modifications for PTPRCAP Gene

Other Protein References for PTPRCAP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PTPRCAP Gene

Domains & Families for PTPRCAP Gene

Protein Domains for PTPRCAP Gene

Suggested Antigen Peptide Sequences for PTPRCAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PTPRCAP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PTPRCAP Gene

Function for PTPRCAP Gene

Molecular function for PTPRCAP Gene

GENATLAS Biochemistry:
phosphotyrosine phosphatase,receptor-type 1,CD45,(PTPRC) associated protein,32kDa

Phenotypes for PTPRCAP Gene

MGI mutant phenotypes for PTPRCAP:
inferred from 3 alleles
GenomeRNAi human phenotypes for PTPRCAP:
genes like me logo Genes that share phenotypes with PTPRCAP: view

Animal Models for PTPRCAP Gene

MGI Knock Outs for PTPRCAP:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRCAP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for PTPRCAP Gene

Localization for PTPRCAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRCAP Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRCAP Gene COMPARTMENTS Subcellular localization image for PTPRCAP gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PTPRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 11390434
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTPRCAP: view

Pathways & Interactions for PTPRCAP Gene

SuperPathways for PTPRCAP Gene

No Data Available

Interacting Proteins for PTPRCAP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000325589%0d%0a9606.ENSP00000368552%0d%0a9606.ENSP00000337825%0d%0a
Selected Interacting proteins: Q14761-PTCA_HUMAN ENSP00000325589 for PTPRCAP Gene via I2D MINT STRING

Gene Ontology (GO) - Biological Process for PTPRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 7961877
genes like me logo Genes that share ontologies with PTPRCAP: view

No data available for Pathways by source and SIGNOR curated interactions for PTPRCAP Gene

Drugs & Compounds for PTPRCAP Gene

(1) Drugs for PTPRCAP Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tyrosine Nutra 547
genes like me logo Genes that share compounds with PTPRCAP: view

Transcripts for PTPRCAP Gene

mRNA/cDNA for PTPRCAP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(629) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTPRCAP Gene

Protein tyrosine phosphatase, receptor type, C-associated protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRCAP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRCAP Gene

No ASD Table

Relevant External Links for PTPRCAP Gene

GeneLoc Exon Structure for
PTPRCAP
ECgene alternative splicing isoforms for
PTPRCAP

Expression for PTPRCAP Gene

mRNA expression in normal human tissues for PTPRCAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRCAP Gene

This gene is overexpressed in Whole Blood (x17.3) and Spleen (x9.1).

Protein differential expression in normal tissues from HIPED for PTPRCAP Gene

This gene is overexpressed in NK cells (15.1), Tlymphocyte (13.6), Lymph node (10.9), Blymphocyte (9.1), and CD4 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRCAP Gene



SOURCE GeneReport for Unigene cluster for PTPRCAP Gene Hs.155975

genes like me logo Genes that share expression patterns with PTPRCAP: view

Protein tissue co-expression partners for PTPRCAP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PTPRCAP Gene

Orthologs for PTPRCAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTPRCAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRCAP 35
  • 76.73 (n)
  • 72.77 (a)
PTPRCAP 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprcap 35
  • 74.49 (n)
  • 68.37 (a)
Ptprcap 16
Ptprcap 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPRCAP 35
  • 99.35 (n)
  • 99.51 (a)
PTPRCAP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprcap 35
  • 74.83 (n)
  • 68.88 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPRCAP 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRCAP 36
  • 33 (a)
OneToOne
Species with no ortholog for PTPRCAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTPRCAP Gene

ENSEMBL:
Gene Tree for PTPRCAP (if available)
TreeFam:
Gene Tree for PTPRCAP (if available)

Paralogs for PTPRCAP Gene

No data available for Paralogs for PTPRCAP Gene

Variants for PTPRCAP Gene

Sequence variations from dbSNP and Humsavar for PTPRCAP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_061698 -

Structural Variations from Database of Genomic Variants (DGV) for PTPRCAP Gene

Variant ID Type Subtype PubMed ID
nsv897797 CNV Loss 21882294
nsv897801 CNV Loss 21882294
nsv897804 CNV Gain 21882294
dgv1193n71 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
nsv897811 CNV Loss 21882294
nsv521723 CNV Loss 19592680
nsv524096 CNV Loss 19592680
nsv468604 CNV Loss 19166990

Variation tolerance for PTPRCAP Gene

Residual Variation Intolerance Score: 86.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRCAP Gene

HapMap Linkage Disequilibrium report
PTPRCAP
Human Gene Mutation Database (HGMD)
PTPRCAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRCAP Gene

Disorders for PTPRCAP Gene

Relevant External Links for PTPRCAP

Genetic Association Database (GAD)
PTPRCAP
Human Genome Epidemiology (HuGE) Navigator
PTPRCAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRCAP
genes like me logo Genes that share disorders with PTPRCAP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPRCAP Gene

Publications for PTPRCAP Gene

  1. Biochemical analysis of the CD45-p56(lck) complex in Jurkat T cells lacking expression of lymphocyte phosphatase-associated phosphoprotein. (PMID: 9533446) Bruyns E. … Schraven B. (Int. Immunol. 1998) 23 67
  2. Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells. (PMID: 8980254) Shimizu Y. … Kishimoto T. (Am. J. Hematol. 1997) 23 67
  3. CD45-associated protein is a lymphocyte-specific membrane protein expressed in two distinct forms. (PMID: 9045908) Kitamura K. … Takeda A. (Eur. J. Immunol. 1997) 23 67
  4. Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes. (PMID: 8954783) Bruyns E. … Schraven B. (Genomics 1996) 23 67
  5. Assignment of the CD45-AP gene to the centromeric end of mouse chromosome 19 and human chromosome 11q13.1-q13.3. (PMID: 8975722) Takai S. … Takeda A. (Genomics 1996) 23 67

Products for PTPRCAP Gene

Sources for PTPRCAP Gene

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