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Aliases for PTPRCAP Gene

Aliases for PTPRCAP Gene

  • Protein Tyrosine Phosphatase, Receptor Type C Associated Protein 2 3 5
  • Lymphocyte Phosphatase-Associated Phosphoprotein 3 4
  • PTPRC-Associated Protein 3 4
  • CD45-AP 3 4
  • LPAP 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide-Associated Protein 3
  • Protein Tyrosine Phosphatase Receptor Type C-Associated Protein 3
  • CD45 Associated Protein 3
  • CD45-Associated Protein 4

External Ids for PTPRCAP Gene

Previous GeneCards Identifiers for PTPRCAP Gene

  • GC11P069666
  • GC11M068899
  • GC11M066978
  • GC11M066959
  • GC11M067202
  • GC11M063531

Summaries for PTPRCAP Gene

Entrez Gene Summary for PTPRCAP Gene

  • The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRCAP Gene

PTPRCAP (Protein Tyrosine Phosphatase, Receptor Type C Associated Protein) is a Protein Coding gene. Among its related pathways are TNFR1 Pathway.

Gene Wiki entry for PTPRCAP Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRCAP Gene

Genomics for PTPRCAP Gene

Regulatory Elements for PTPRCAP Gene

Enhancers for PTPRCAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G067482 1.7 FANTOM5 ENCODE dbSUPER 54.4 -47.3 -47301 6.3 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 PTPRCAP RBM4B RBM14 CARNS1 ENSG00000258297 ALDH3B2 NUDT8 AIP GC11P067486
GH11G067433 1.3 Ensembl ENCODE 57.4 -2.3 -2312 14.7 HDGF ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS PTPRCAP CARNS1 SSH3 CORO1B
GH11G067467 1.3 ENCODE dbSUPER 55.3 -30.5 -30455 2.7 PKNOX1 AGO1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF207 ZNF143 PTPRCAP CARNS1 TMEM134 GC11M067462
GH11G067427 1.1 ENCODE 55.6 +9.5 9484 2.5 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1 PTPRCAP CARNS1 RPS6KB2 ENSG00000255949
GH11G067544 1.5 Ensembl ENCODE dbSUPER 28.8 -106.8 -106845 1.4 PKNOX1 ATF1 ARNT SIN3A YY1 ZNF766 GATA2 ELK1 FOS NFYC PTPRCAP ALDH3B2 FAM86C2P GC11M067541 GSTP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTPRCAP on UCSC Golden Path with GeneCards custom track

Promoters for PTPRCAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041106 382 601 TBP TBL1XR1 AGO1 ZNF207 ETV6 SMAD5 CBFB GATAD2B SP1 IKZF1

Genomic Location for PTPRCAP Gene

Chromosome:
11
Start:
67,435,510 bp from pter
End:
67,438,067 bp from pter
Size:
2,558 bases
Orientation:
Minus strand

Genomic View for PTPRCAP Gene

Genes around PTPRCAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRCAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRCAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRCAP Gene

Proteins for PTPRCAP Gene

  • Protein details for PTPRCAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14761-PTCA_HUMAN
    Recommended name:
    Protein tyrosine phosphatase receptor type C-associated protein
    Protein Accession:
    Q14761
    Secondary Accessions:
    • B2R512
    • O00643
    • Q6I9S6

    Protein attributes for PTPRCAP Gene

    Size:
    206 amino acids
    Molecular mass:
    21196 Da
    Quaternary structure:
    • Interacts with CD45/PTPRC.

neXtProt entry for PTPRCAP Gene

Post-translational modifications for PTPRCAP Gene

Other Protein References for PTPRCAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTPRCAP Gene

Domains & Families for PTPRCAP Gene

Protein Domains for PTPRCAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTPRCAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PTPRCAP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PTPRCAP Gene

Function for PTPRCAP Gene

Molecular function for PTPRCAP Gene

GENATLAS Biochemistry:
phosphotyrosine phosphatase,receptor-type 1,CD45,(PTPRC) associated protein,32kDa
genes like me logo Genes that share phenotypes with PTPRCAP: view

Animal Models for PTPRCAP Gene

MGI Knock Outs for PTPRCAP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PTPRCAP Gene

Localization for PTPRCAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRCAP Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPRCAP gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PTPRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 11390434
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTPRCAP: view

Pathways & Interactions for PTPRCAP Gene

SuperPathways for PTPRCAP Gene

SuperPathway Contained pathways
1 TNFR1 Pathway
genes like me logo Genes that share pathways with PTPRCAP: view

Pathways by source for PTPRCAP Gene

1 BioSystems pathway for PTPRCAP Gene

Gene Ontology (GO) - Biological Process for PTPRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 7961877
genes like me logo Genes that share ontologies with PTPRCAP: view

No data available for SIGNOR curated interactions for PTPRCAP Gene

Drugs & Compounds for PTPRCAP Gene

(1) Drugs for PTPRCAP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PTPRCAP: view

Transcripts for PTPRCAP Gene

mRNA/cDNA for PTPRCAP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(629) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTPRCAP Gene

Protein tyrosine phosphatase, receptor type, C-associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRCAP Gene

No ASD Table

Relevant External Links for PTPRCAP Gene

GeneLoc Exon Structure for
PTPRCAP
ECgene alternative splicing isoforms for
PTPRCAP

Expression for PTPRCAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTPRCAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRCAP Gene

This gene is overexpressed in Whole Blood (x17.3) and Spleen (x9.1).

Protein differential expression in normal tissues from HIPED for PTPRCAP Gene

This gene is overexpressed in NK cells (15.1), Tlymphocyte (13.6), Lymph node (10.9), Blymphocyte (9.1), and CD4 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTPRCAP Gene



Protein tissue co-expression partners for PTPRCAP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTPRCAP Gene:

PTPRCAP

SOURCE GeneReport for Unigene cluster for PTPRCAP Gene:

Hs.155975

Evidence on tissue expression from TISSUES for PTPRCAP Gene

  • Blood(4.4)
  • Liver(4.1)
  • Intestine(2.5)
genes like me logo Genes that share expression patterns with PTPRCAP: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPRCAP Gene

Orthologs for PTPRCAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTPRCAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRCAP 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia PTPRCAP 34 35
  • 76.73 (n)
rat
(Rattus norvegicus)
Mammalia Ptprcap 34
  • 74.83 (n)
mouse
(Mus musculus)
Mammalia Ptprcap 34 16 35
  • 74.49 (n)
oppossum
(Monodelphis domestica)
Mammalia PTPRCAP 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRCAP 35
  • 33 (a)
OneToOne
Species where no ortholog for PTPRCAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTPRCAP Gene

ENSEMBL:
Gene Tree for PTPRCAP (if available)
TreeFam:
Gene Tree for PTPRCAP (if available)

Paralogs for PTPRCAP Gene

No data available for Paralogs for PTPRCAP Gene

Variants for PTPRCAP Gene

Sequence variations from dbSNP and Humsavar for PTPRCAP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000306398 -- 67,435,821(+) GGTCA(-/CTCAGCAGGGC)CTCAG downstream-variant-500B, reference, frameshift-variant
rs1001235173 -- 67,438,919(+) TGTGT(C/T)GGGGT upstream-variant-2KB, reference, missense
rs1001436161 -- 67,437,788(+) AGACC(C/T)TCCCC intron-variant, upstream-variant-2KB
rs1001510902 -- 67,437,490(+) CCATA(C/T)TCCTC intron-variant
rs1001846227 -- 67,436,571(+) CCCAA(-/CAGCTG)CATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRCAP Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
nsv468604 CNV loss 19166990
nsv521723 CNV loss 19592680
nsv524096 CNV loss 19592680

Variation tolerance for PTPRCAP Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRCAP Gene

Human Gene Mutation Database (HGMD)
PTPRCAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPRCAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRCAP Gene

Disorders for PTPRCAP Gene

Relevant External Links for PTPRCAP

Genetic Association Database (GAD)
PTPRCAP
Human Genome Epidemiology (HuGE) Navigator
PTPRCAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRCAP

No disorders were found for PTPRCAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPRCAP Gene

Publications for PTPRCAP Gene

  1. Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes. (PMID: 8954783) Bruyns E. … Schraven B. (Genomics 1996) 3 4 22 64
  2. Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45. (PMID: 8537410) Bruyns E. … Schraven B. (J. Biol. Chem. 1995) 3 4 22 64
  3. LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes. (PMID: 7961877) Schraven B. … Meuer S. (J. Biol. Chem. 1994) 3 4 22 64
  4. A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression. (PMID: 20019842) Ju H. … Kang C. (Neoplasia 2009) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PTPRCAP Gene

Sources for PTPRCAP Gene

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