PTPRC Gene
protein-coding GIFtS : 73 GCID: GC01 P198607
protein tyrosine phosphatase, receptor type, C CD45 )
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor PTPRC gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Protein Tyrosine Phosphatase, Receptor Type, C 1 2 CD45R2 CD451 2 3 5 LY52 T2001 2 3 Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide2 LCA1 2 5 Receptor-Type Tyrosine-Protein Phosphatase C2 GP1801 2 T200 Glycoprotein2 L-CA2 3 T200 Leukocyte Common Antigen2 CD45 Antigen2 3 EC 3.1.3.483 B2202 Leukocyte Common Antigen3
Export aliases for PTPRC gene to outside databases Previous GC identifers: GC01P196335 GC01P194066 GC01P195074 GC01P195896 GC01P195339 GC01P196874 GC01P169775
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor PTPRC gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for PTPRC : The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. (provided by RefSeq, Jun 2012) UniProtKB/Swiss-Prot: PTPRC_HUMAN, P08575 Function : Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as apositive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) Gene Wiki entry for PTPRC
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor PTPRC gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PTPRC gene promoter:AP-1 ATF-2 Nkx2-5 Other transcription factors Search SABiosciences Chromatin IP Primers for PTPRC Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPRC
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q31-q32 Ensembl cytogenetic band: 1q31.3 HGNC cytogenetic band: 1q31-q32 PTPRC Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P198607: view genomic region
(about GC identifiers )
Start: 198,607,801 bp from pter End:
198,726,545 bp from pter
Size: 118,745 bases Orientation:
plus strand
1 alternative location : Chr 1+,PATCHES 198,613,881-198,693,175
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor PTPRC gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PTPRC_HUMAN, P08575 See
protein sequence )Recommended Name: Size : 1304 amino acids; 147254 DaSubunit : Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1. Interacts with DPP4; the interaction is enhancedin a interleukin-12-dependent manner in activated lymphocytes
Subcellular location : Membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 inmembrane rafts
2 PDB 3D structures from :1YGR (3D) 1YGU (3D) Secondary accessions : A8K7W6 Q16614 Q9H0Y6Alternative splicing : 2 isoforms : P08575-1 P08575-2 Explore the universe of human proteins at neXtProt for PTPRC: NX_P08575 Post-translational modifications:
Heavily N- and O-glycosylated1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P08575 PTPRC Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts): NP_001254727.1 NP_002829.3 NP_563578.2 ENSEMBL proteins: ENSP00000356349 ENSP00000433536 ENSP00000411355 ENSP00000356337 ENSP00000306782 ENSP00000356334 ENSP00000405494 ENSP00000393360 ENSP00000356346 ENSP00000193532 Reactome Protein details: P08575 Human Recombinant Protein Products: Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8 ): About this table
About GeneDecksing PTPRC Antibody Products: Assay Products for PTPRC:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains /for PTPRC gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry P08575 ProtoNet protein and cluster: P08575
1 Blocks protein family : IPB000242 UniProtKB/Swiss-Prot: PTPRC_HUMAN, P08575 Domain : The first PTPase domain interacts with SKAP1Similarity : Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamilySimilarity : Contains 2 fibronectin type-III domainsSimilarity : Contains 2 tyrosine-protein phosphatase domains
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor PTPRC gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: PTPRC_HUMAN, P08575 Function : Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as apositive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) Catalytic activity : Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Genatlas biochemistry entry for PTPRC protein tyrosine phosphatase,receptor-type I,C polypeptide Enzyme Number (IUBMB): EC 3.1.3.48 1 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 9 )human mouse rat see all 7 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): PTPRC (NM_002838 ) Sino Biological Human cDNA Clone for PTPRC DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTPRC Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PTPRC
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRC
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing 3 GenomeRNAi human phenotypes for PTPRC :Animal Models: Ptprc tm1Holm Ptprc tm1Mak Ptprc tm1Tyb 15 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Ptprc) :About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor PTPRC gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/23 super-pathways (see all 23 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Activation of cAMP-Dependent PKA 2 B cell receptor signaling pathway 3 Immune System 4 Sema4D in semaphorin signaling 5 Axon guidance
Pathway sources See GeneCards unified pathways Show all pathways 3 1 5/10 (see all 10 )1 3 5/6 (see all 6 ) 5/8 (see all 8 )4 (Kegg details for PTPRC) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPRC STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/107 Interacting proteins for PTPRC (P08575 1 , 2 , 3 ENSP00000356346 4 via UniProtKB, MINT, STRING , and/or I2D (see all 107 )Interactant Interaction Details GeneCard External ID(s) LCK P06239 1 , 2 , 3 ENSP00000337825 4 EBI-1341,EBI-1348 MINT-8310416 MINT-8310873 MINT-8311622 MINT-8310398 MINT-8310648 I2D:
score=7 STRING: ENSP00000337825 CSK P41240 2 , 3 ENSP00000220003 4 MINT-8310655 MINT-8310636 I2D:
score=1 STRING: ENSP00000220003 CD22 P20273 2 , 3 ENSP00000085219 4 MINT-8312050 I2D:
score=3 STRING: ENSP00000085219 SEMA4D Q92854 2 , 3 ENSP00000343418 4 MINT-8312043 I2D:
score=3 STRING: ENSP00000343418 ERBB2 P04626 1 , 3 ENSP00000269571 4 EBI-1341,EBI-641062 I2D:
score=1 STRING: ENSP00000269571
About this table Gene Ontology (GO): 5/50 biological process terms (GO ID links to tree view) (see all 50 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000187 activation of MAPK activity
-- -- GO:0001915 negative regulation of T cell mediated cytotoxicity
ISS -- GO:0001916 positive regulation of T cell mediated cytotoxicity
-- -- GO:0001960 negative regulation of cytokine-mediated signaling pathway
ISS -- GO:0002244 hematopoietic progenitor cell differentiation
IMP --
About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor PTPRC gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for PTPRC
Browse Tocris compounds for PTPRC 2 HMDB Compounds for PTPRC About this table 10/65 Novoseek chemical compound relationships for PTPRC gene (see all 65 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine
75.2
326
7516335 (4), 8011300 (4), 1652760 (4), 1371471 (4) (see all 99 )
phosphotyrosine
68.9
23
1361757 (3), 1682382 (2), 1710891 (1), 16266868 (1) (see all 19 )
ziram
65.1
7
7522974 (1), 2138598 (1), 1830500 (1)
[alcl]
53.8
2
1330283 (1), 18323280 (1)
naphthol as-d chloroacetate
53.6
2
2031458 (1), 2106752 (1)
paraffin
48.1
17
1376944 (1), 8337941 (1), 10365929 (1), 16911464 (1) (see all 13 )
monochloroacetic acid
45.2
3
10199480 (1), 10578990 (1)
b 723
44.7
3
1710419 (1), 1689123 (1), 1709321 (1)
p-nitrophenyl phosphate
40.8
1
12215216 (1)
herbimycin a
37.2
1
7908233 (1)
PTPRC
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor PTPRC gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for PTPRC gene (4 alternative transcripts): NM_001267798.1 NM_002838.4 NM_080921.3 NM_080922.2 Unigene Cluster for PTPRC:
Protein tyrosine phosphatase, receptor type, C Hs.654514 [show with all ESTs ] Unigene Representative Sequence: NM_002838 16 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000367379 ENST00000530727 ENST00000442510 (uc001guu.1 ) ENST00000462363 (uc001guw.1 uc009wze.1 )ENST00000367367 (uc001guv.1 ) ENST00000348564 ENST00000367364 (uc001guq.3 )ENST00000413409 ENST00000529828 ENST00000418674 ENST00000427110 ENST00000391970 ENST00000484135 ENST00000491302 ENST00000367376 (uc010ppg.1 uc001gur.1 )ENST00000352140 (uc009wzf.1 uc021pgy.1 uc001gut.1 ) Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 9 )human mouse rat see all 7 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): PTPRC (NM_002838 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTPRC Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PTPRC
Additional cDNA sequence: AK130573.1 AK292131.1 AK299986.1 AK303539.1 AK307635.1 AK308217.1 AK310898.1 AY429565.1 AY429566.1 AY567999.1 BC014239.2 BC017863.1 BC031525.1 BC121086.1 BC121087.1 BC127656.1 BC127657.1 BC148257.1 NR_052021.1 Y00062.1 Y00638.1
24/34 DOTS entries (see all 34 ): DT.91865616 DT.97839257
DT.415341 DT.100816605 DT.99965985 DT.91985039 DT.95321602 DT.40261905 DT.91638349 DT.99999416 DT.100816604 DT.121393941 DT.99947129 DT.121393829 DT.121393843 DT.40220962 DT.91757224 DT.95324604 DT.100023408 DT.121393811 DT.121393815 DT.121393853 DT.121393916 DT.86859254 24/263 AceView cDNA sequences (see all 263 ):
BM991731 NM_080923 BM801036 AI374817 AI433565 BQ029407 BX415648 AA361747 AI872685 CD366621 BM458704 BU753482 AI432977 AI249443 AI185650 AI880581 AA780379 CB157202 AI416959 BU679708 NM_002838 BX437239 AK130573 AI367985 GeneLoc Exon Structure 5/17 Alternative Splicing Database (ASD) splice patterns (SP) for PTPRC (see all 17 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ SP1 : - - - - - - - SP2 : SP3 : SP4 : SP5 : - - - - - -
ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29a · 29b ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b ^ SP1 : SP2 : - SP3 : SP4 : - SP5 :
ECgene alternative splicing isoforms for PTPRC
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for PTPRC gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section PTPRC expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTAAATCCCA
About this image PTPRC expression in embryonic tissues and stem cells About this table See PTPRC Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PTPRC SOURCE GeneReport for Unigene cluster: Hs.654514 SABiosciences Expression via Pathway-Focused PCR Arrays including PTPRC (see all 10 ): Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRC
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor PTPRC gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for PTPRC gene from 7/22 species (see all 22 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves PTPRC1
protein tyrosine phosphatase, receptor type, C
62.72(n) 54.71(a)
386580 NM_204417.1 NP_989748.1
lizard Reptilia PTPRC6
--
58(a)
1 ↔ 1
GL343211.1(618818-655685)
African clawed frog Amphibia ptprc-A-prov2
protein tyrosine phosphatase, receptor type, C
77.41(n)
AF024438.1
zebrafish Actinopterygii Dr.125362
Transcribed sequence with weak similarity to protein more
76.05(n)
CK142444.1
fruit fly Insecta Ptp52F3
axon guidance protein tyrosine phosphatase
45(a)
52F3 --
thale cress eudicotyledons ATPTP16
tyrosine phosphatase 1
28(a)
1 → many
1(27026711-27029092)
rice Liliopsida ----
Protein-tyrosine phosphatase domain containing pro... Protein-tyrosine phosphatase domain containing pro... 32(a) 22(a)
many ↔ manymany ↔ many
12(3791109-3796496) 11(4000708-4008336)
ENSEMBL Gene Tree for PTPRC (if available)TreeFam Gene Tree for PTPRC (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor PTPRC gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for PTPRC gene PTPRK 2 PTPRA 2 PTPRG 2 PTPRD 2 PTPRS 2 PTPRF 2 PTPRM 2 PTPRU 2 PTPRZ1 2 PTPRT 2 PTPRE 2 18/19 SIMAP similar genes for PTPRC using alignment to 19 protein entries: PTPRC_HUMAN (see all proteins )
(see all similar genes ):DKFZp313F1310 DKFZp781C1038 PTPN7 PTPRA PTPRR PTPRE DKFZp761A0712 PTPN12 BPTP-2 PTPRS DKFZp566K0524 PTPN20A PTPN20B PTPN22 PTPN5 BPTP-3 DKFZp686K0257 PTPN1 About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor PTPRC gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 1 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for PTPRC (198607801 - 198726545 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for PTPRC 1 CNV 39027 1 Indel 58355 Human Gene Mutation Database (HGMD) : PTPRC Locus Specific Mutation Databases (LSDB): PTPRC 2 SABiosciences Cancer Mutation PCR Assays for PTPRC :
QIAGEN SeqTarget long-range PCR primers in human mouse rat
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor PTPRC gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 151460 OMIM disorders : 609532 608971 UniProtKB/Swiss-Prot: PTPRC_HUMAN, P08575 Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain 20/156 (see all 156 ): About MalaCards hepatitic c virus severe combined immunodeficiency primitive neuroectodermal tumor lymphoepithelioma-like carcinoma b-cell non-hodgkin lymphoma supratentorial primitive neuroectodermal tumor malignant fibrous histiocytoma fibrous histiocytoma anaplastic large cell lymphoma diffuse large b-cell lymphoma waldenstrom macroglobulinemia human t-cell leukemia virus type 1 hypersensitivity reaction type ii disease non-hodgkin lymphoma human immunodeficiency virus infectious disease combined immunodeficiency central nervous system lymphoma periventricular leukomalacia follicular dendritic cell tumor autoimmune lymphoproliferative syndrome 4 diseases from the University of Copenhagen DISEASES database for PTPRC :Lymphoma Hypersensitivity reaction type II disease Malignant histiocytosis Leukemia 10/92 Novoseek disease relationships for PTPRC gene (see all 92 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
anaplastic large cell lymphoma
73.5
2
2042431 (1), 1313610 (1)
lymphoma large cell
71.5
3
1335094 (1), 9870851 (1), 20415195 (1)
lymphoma
68.3
57
1376944 (4), 1330287 (4), 15583810 (3), 11378582 (3) (see all 31 )
sarcoma granulocytic
61
4
8037168 (2), 17700206 (1), 2106752 (1)
lymphoma lymphoblastic
54.9
3
11190795 (1), 7503935 (1)
lymphoma non-hodgkins
52.8
4
1829834 (1), 1845482 (1), 1669003 (1)
ewings sarcoma
51.9
5
11190795 (1), 1669003 (1), 7503935 (1), 1497115 (1) (see all 5 )
tumors
50.3
101
8656013 (2), 15945093 (2), 17425998 (2), 8127145 (2) (see all 83 )
primitive neuroectodermal tumor pnet
49.1
1
12783138 (1)
lymphoma t-cell peripheral
45.8
2
1813158 (1), 12588355 (1)
Genetic Association Database (GAD): PTPRC Human Genome Epidemiology (HuGE) Navigator: PTPRC (37 documents) Export disorders for PTPRC gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor PTPRC gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for PTPRC gene, integrated from 9 sources (see all 823 ):(articles sorted by number of sources associating them with PTPRC) Utopia : connect your pdf to the dynamic
A point mutation in PTPRC is associated with the development of multiple sclerosis. (PubMed id 11101853) 1 , 2 , 4, 9(2000) A deletion in the gene encoding the CD45 antigen in a patient with SCID. (PubMed id 11145714) 1 , 2 , 9(2001) PTPRC (CD45) is not associated with multiple sclerosis in a large cohort of German patients. (PubMed id 12028593) 1 , 4, 9(2002) PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. (PubMed id 11528386) 1 , 4, 9(2001) A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population. (PubMed id 15548260) 1 , 4, 9(2004) CD45 and multiple sclerosis: the exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers. (PubMed id 12864992) 1 , 4, 9(2003) Protein tyrosine phosphatase receptor-type C exon 4 gene mutation distribution in an Italian multiple sclerosis population. (PubMed id 12147336) 1 , 4, 9(2002) The 77C->G mutation in the human CD45 (PTPRC) gene leads to increased intensity of TCR signaling in T cell lines from healthy individuals and patients with multiple sclerosis. (PubMed id 16393978) 1 , 4, 9(2006) [Prevalence of C77G polymorphism in exon 4 of the CD45 gene in the Spanish population] (PubMed id 15960938) 1 , 4, 9(2005) C77G mutation in protein tyrosine phosphatase CD45 gene and autoimmune hepatitis. (PubMed id 15963758) 1 , 4, 9(2005)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for PTPRC gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing PTPRC gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing PTPRC gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing PTPRC gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for PTPRC gene: PTPRC GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor PTPRC gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for PTPRC OriGene shRNA RFP for PTPRC OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for PTPRC Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for PTPRC OriGene 3'-UTR Clone for PTPRC OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for PTPRC OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for PTPRC OriGene Custom Protein Services for PTPRC OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTPRC QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPRC QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for PTPRC (CD45)
Search Tocris compounds for PTPRC
Recombinant Protein for PTPRC
PTPRC Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRC
ThermoFisher Antibody for PTPRC
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PTPRC
Jump to Section...
Aliases for PTPRC
Databases for PTPRC
Disorders / Diseases for PTPRC
Domains / Families for PTPRC
Drugs / Compounds for PTPRC
Expression for PTPRC
Function for PTPRC
Genomic Views for PTPRC
Intellectual Property for PTPRC
Orthologs for PTPRC
Paralogs for PTPRC
Pathways / Interactions for PTPRC
Products for PTPRC
Proteins for PTPRC
Publications for PTPRC
Search Box for PTPRC
Summaries for PTPRC
Transcripts for PTPRC
Variants for PTPRC
TOP
BOTTOM
and Proteopedia 
for PTPRC:
GeneGo (Thomson Reuters) Pathways for PTPRC
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Positive 
Microarrays
In-situ hybridization
