Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PTPRC Gene

Aliases for PTPRC Gene

  • Protein Tyrosine Phosphatase, Receptor Type, C 2 3
  • CD45 3 4 6
  • CD45 Antigen 3 4
  • L-CA 3 4
  • T200 3 4
  • LCA 3 6
  • Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide 3
  • Receptor-Type Tyrosine-Protein Phosphatase C 3
  • T200 Leukocyte Common Antigen 3
  • Leukocyte Common Antigen 4
  • T200 Glycoprotein 3
  • EC 3.1.3.48 4
  • GP180 3
  • CD45R 3
  • B220 3
  • LY5 3

External Ids for PTPRC Gene

Previous Symbols for PTPRC Gene

  • CD45

Summaries for PTPRC Gene

Entrez Gene Summary for PTPRC Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

GeneCards Summary for PTPRC Gene

PTPRC (Protein Tyrosine Phosphatase, Receptor Type, C) is a Protein Coding gene. Diseases associated with PTPRC include testicular lymphoma and t-b+ severe combined immunodeficiency due to cd45 deficiency. Among its related pathways are Class I MHC mediated antigen processing and presentation and L1CAM interactions. GO annotations related to this gene include protein kinase binding and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRT.

UniProtKB/Swiss-Prot for PTPRC Gene

  • Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Gene Wiki entry for PTPRC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRC Gene

Genomics for PTPRC Gene

Genomic Location for PTPRC Gene

Start:
198,638,671 bp from pter
End:
198,757,476 bp from pter
Size:
118,806 bases
Orientation:
Plus strand

Genomic View for PTPRC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRC Gene

Regulatory Elements for PTPRC Gene

Transcription factor binding sites by QIAGEN in the PTPRC gene promoter:

Proteins for PTPRC Gene

  • Protein details for PTPRC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08575-PTPRC_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase C
    Protein Accession:
    P08575
    Secondary Accessions:
    • A8K7W6
    • Q16614
    • Q9H0Y6

    Protein attributes for PTPRC Gene

    Size:
    1304 amino acids
    Molecular mass:
    147254 Da
    Quaternary structure:
    • Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Interacts with human cytomegalovirus protein UL11.

    Three dimensional structures from OCA and Proteopedia for PTPRC Gene

    Alternative splice isoforms for PTPRC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRC Gene

Proteomics data for PTPRC Gene at MOPED

Post-translational modifications for PTPRC Gene

  • Heavily N- and O-glycosylated.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys664, Lys715, and Lys932
  • Glycosylation at Asn78, Asn90, Asn95, Asn184, Asn190, Asn197, Asn232, Asn240, Asn260, Asn270, Asn276, Asn284, Asn335, Asn378, Asn419, Asn468, Asn488, Asn497, and Asn529

No data available for DME Specific Peptides for PTPRC Gene

Domains for PTPRC Gene

Gene Families for PTPRC Gene

HGNC:
  • CD :CD molecules
  • FN3 :Fibronectin type III domain containing
  • PTPR :Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like
IUPHAR :

UniProtKB/Swiss-Prot:

PTPRC_HUMAN
Domain:
  • The first PTPase domain interacts with SKAP1:
    • P08575
  • Contains 2 fibronectin type-III domains.:
    • P08575
  • Contains 2 tyrosine-protein phosphatase domains.:
    • P08575
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.:
    • P08575
genes like me logo Genes that share domains with PTPRC: view

Function for PTPRC Gene

Molecular function for PTPRC Gene

GENATLAS Biochemistry: protein tyrosine phosphatase,receptor-type I,C polypeptide
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Enzyme Numbers (IUBMB) for PTPRC Gene

Gene Ontology (GO) - Molecular Function for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IDA 2853967
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 2845400
GO:0005515 protein binding IPI 10369126
GO:0008201 heparin binding --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPRC: view
genes like me logo Genes that share phenotypes with PTPRC: view

Animal Models for PTPRC Gene

MGI Knock Outs for PTPRC:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PTPRC Gene

Localization for PTPRC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRC Gene

Membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRC Gene COMPARTMENTS Subcellular localization image for PTPRC gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
extracellular 2
nucleus 2
peroxisome 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0005925 focal adhesion ISS --
GO:0009897 external side of plasma membrane IDA 17213291
GO:0009986 cell surface IDA 24337748
genes like me logo Genes that share ontologies with PTPRC: view

Pathways for PTPRC Gene

genes like me logo Genes that share pathways with PTPRC: view

Gene Ontology (GO) - Biological Process for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity --
GO:0001915 negative regulation of T cell mediated cytotoxicity ISS --
GO:0001916 positive regulation of T cell mediated cytotoxicity --
GO:0001960 negative regulation of cytokine-mediated signaling pathway ISS --
GO:0002244 hematopoietic progenitor cell differentiation IMP 21911094
genes like me logo Genes that share ontologies with PTPRC: view

Compounds for PTPRC Gene

(2) HMDB Compounds for PTPRC Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(65) Novoseek inferred chemical compound relationships for PTPRC Gene

Compound -log(P) Hits PubMed IDs
tyrosine 75.2 164
phosphotyrosine 68.9 22
ziram 65.1 3
[alcl] 53.8 2
naphthol as-d chloroacetate 53.6 2

(4) PharmGKB related drug/compound annotations for PTPRC Gene

genes like me logo Genes that share compounds with PTPRC: view

Transcripts for PTPRC Gene

Unigene Clusters for PTPRC Gene

Protein tyrosine phosphatase, receptor type, C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRC Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5: - - - - - -
SP6: - - -
SP7: - - - - -
SP8: - - - -
SP9: - -
SP10: - - - - - -
SP11: - -
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29a · 29b ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b ^
SP1:
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for PTPRC Gene

GeneLoc Exon Structure for
PTPRC
ECgene alternative splicing isoforms for
PTPRC

Expression for PTPRC Gene

mRNA expression in normal human tissues for PTPRC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRC Gene

This gene is overexpressed in Whole Blood (30.3) and Spleen (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PTPRC Gene

SOURCE GeneReport for Unigene cluster for PTPRC Gene Hs.654514

genes like me logo Genes that share expressions with PTPRC: view

Orthologs for PTPRC Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRC 36
  • 99.03 (n)
  • 98.47 (a)
PTPRC 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRC 36
  • 74.32 (n)
  • 69.07 (a)
PTPRC 37
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRC 36
  • 79.77 (n)
  • 70.94 (a)
PTPRC 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprc 36
  • 74.86 (n)
  • 69.58 (a)
Ptprc 16
Ptprc 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPRC 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 9 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ptprc 36
  • 74.22 (n)
  • 67.69 (a)
chicken
(Gallus gallus)
Aves PTPRC 36
  • 62.91 (n)
  • 55.3 (a)
PTPRC 37
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRC 37
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ptprc-A-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprc 36
  • 60.57 (n)
  • 53.23 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12536 36
ptprc 36
  • 56.1 (n)
  • 46.36 (a)
ptprc 37
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ptp69D 37
  • 20 (a)
OneToOne
Ptp69D 38
  • 37 (a)
Ptp52F 38
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea clr-1 37
  • 19 (a)
OneToOne
ZK616.7 38
  • 34 (a)
F47B3.6 38
  • 34 (a)
T27A3.5 38
  • 35 (a)
F36H12.10 38
  • 38 (a)
C55B7.3 38
  • 30 (a)
T22C1.8 38
  • 33 (a)
F47B3.1 38
  • 34 (a)
M04G7.2 38
  • 33 (a)
C17H12.3 38
  • 34 (a)
C02B10.6 38
  • 38 (a)
F47B3.7 38
  • 36 (a)
Species with no ortholog for PTPRC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRC Gene

ENSEMBL:
Gene Tree for PTPRC (if available)
TreeFam:
Gene Tree for PTPRC (if available)

Paralogs for PTPRC Gene

Paralogs for PTPRC Gene

genes like me logo Genes that share paralogs with PTPRC: view

Variants for PTPRC Gene

Sequence variations from dbSNP and Humsavar for PTPRC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs726879 -- 198,647,571(-) AGGAA(A/G)AAAAA intron-variant
rs874909 -- 198,750,844(+) TTGCA(C/T)GCTGC intron-variant
rs956350 -- 198,647,364(-) TTGTT(C/T)AGCAA intron-variant
rs1011338 -- 198,723,235(-) TAACC(A/G)GTAGA intron-variant
rs1052238 -- 198,665,496(+) AAAAC(C/T)AGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRC Gene

Variant ID Type Subtype PubMed ID
nsv873080 CNV Gain 21882294
esv2721206 CNV Deletion 23290073
nsv819406 CNV Loss 19587683

Relevant External Links for PTPRC Gene

HapMap Linkage Disequilibrium report
PTPRC
Human Gene Mutation Database (HGMD)
PTPRC
Locus Specific Mutation Databases (LSDB)
PTPRC

Disorders for PTPRC Gene

(2) OMIM Diseases for PTPRC Gene (151460)

UniProtKB/Swiss-Prot

PTPRC_HUMAN
  • Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. {ECO:0000269 PubMed:11145714}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. {ECO:0000269 PubMed:11101853}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for PTPRC Gene

(92) Novoseek inferred disease relationships for PTPRC Gene

Disease -log(P) Hits PubMed IDs
anaplastic large cell lymphoma 73.5 2
lymphoma large cell 71.5 3
lymphoma 68.3 46
sarcoma granulocytic 61 4
lymphoma lymphoblastic 54.9 2

Relevant External Links for PTPRC

Genetic Association Database (GAD)
PTPRC
Human Genome Epidemiology (HuGE) Navigator
PTPRC
genes like me logo Genes that share disorders with PTPRC: view

Publications for PTPRC Gene

  1. A point mutation in PTPRC is associated with the development of multiple sclerosis. (PMID: 11101853) Jacobsen M. … Hemmer B. (Nat. Genet. 2000) 3 4 23 49
  2. A deletion in the gene encoding the CD45 antigen in a patient with SCID. (PMID: 11145714) Tchilian E.Z. … Beverley P.C.L. (J. Immunol. 2001) 3 4 23
  3. CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease. (PMID: 11841494) Wood J.P. … Badenhoop K. (Eur. J. Immunogenet. 2002) 3 23 49
  4. PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. (PMID: 11528386) Barcellos L.F. … Oksenberg J.R. (Nat. Genet. 2001) 3 23 49
  5. Does 77C-->G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus? (PMID: 11548742) Vorechovsky I. … Beverley P.C. (Nat. Genet. 2001) 3 23 49

Products for PTPRC Gene

Sources for PTPRC Gene

Back to Top

Content