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Aliases for PTPRC Gene

Aliases for PTPRC Gene

  • Protein Tyrosine Phosphatase, Receptor Type C 2 3
  • Protein Tyrosine Phosphatase, Receptor Type, C 3 5
  • CD45 Antigen 3 4
  • CD45 3 4
  • L-CA 3 4
  • T200 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide 3
  • T200 Leukocyte Common Antigen 3
  • Leukocyte Common Antigen 4
  • T200 Glycoprotein 3
  • EC 3.1.3.48 4
  • GP180 3
  • CD45R 3
  • B220 3
  • LCA 3
  • LY5 3

External Ids for PTPRC Gene

Previous HGNC Symbols for PTPRC Gene

  • CD45

Previous GeneCards Identifiers for PTPRC Gene

  • GC01P196335
  • GC01P194066
  • GC01P195074
  • GC01P195896
  • GC01P195339
  • GC01P196874
  • GC01P169775

Summaries for PTPRC Gene

Entrez Gene Summary for PTPRC Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

GeneCards Summary for PTPRC Gene

PTPRC (Protein Tyrosine Phosphatase, Receptor Type C) is a Protein Coding gene. Diseases associated with PTPRC include severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive and hepatitis c virus. Among its related pathways are A-beta Pathways: Uptake and Degradation and Immune System. GO annotations related to this gene include protein kinase binding and phosphatase activity. An important paralog of this gene is PTPRK.

UniProtKB/Swiss-Prot for PTPRC Gene

  • Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Gene Wiki entry for PTPRC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRC Gene

Genomics for PTPRC Gene

Regulatory Elements for PTPRC Gene

Transcription factor binding sites by QIAGEN in the PTPRC gene promoter:

Genomic Location for PTPRC Gene

Chromosome:
1
Start:
198,638,671 bp from pter
End:
198,757,476 bp from pter
Size:
118,806 bases
Orientation:
Plus strand

Genomic View for PTPRC Gene

Genes around PTPRC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRC Gene

Proteins for PTPRC Gene

  • Protein details for PTPRC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08575-PTPRC_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase C
    Protein Accession:
    P08575
    Secondary Accessions:
    • A8K7W6
    • Q16614
    • Q9H0Y6

    Protein attributes for PTPRC Gene

    Size:
    1304 amino acids
    Molecular mass:
    147254 Da
    Quaternary structure:
    • Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Interacts with human cytomegalovirus protein UL11.

    Three dimensional structures from OCA and Proteopedia for PTPRC Gene

    Alternative splice isoforms for PTPRC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRC Gene

Proteomics data for PTPRC Gene at MOPED

Post-translational modifications for PTPRC Gene

  • Heavily N- and O-glycosylated.
  • Ubiquitination at Lys 664, Lys 715, and Lys 932
  • Glycosylation at Asn 78, Asn 90, Asn 95, Asn 184, Asn 190, Asn 197, Asn 232, Asn 240, Asn 260, Asn 270, Asn 276, Asn 284, Asn 335, Asn 378, Asn 419, Asn 468, Asn 488, Asn 497, and Asn 529
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTPRC (CD45)

Protein Products

No data available for DME Specific Peptides for PTPRC Gene

Domains & Families for PTPRC Gene

Graphical View of Domain Structure for InterPro Entry

P08575

UniProtKB/Swiss-Prot:

PTPRC_HUMAN :
  • The first PTPase domain interacts with SKAP1.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Domain:
  • The first PTPase domain interacts with SKAP1.
  • Contains 2 fibronectin type-III domains.
  • Contains 2 tyrosine-protein phosphatase domains.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
genes like me logo Genes that share domains with PTPRC: view

Function for PTPRC Gene

Molecular function for PTPRC Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type I,C polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Enzyme Numbers (IUBMB) for PTPRC Gene

Gene Ontology (GO) - Molecular Function for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity TAS --
genes like me logo Genes that share ontologies with PTPRC: view
genes like me logo Genes that share phenotypes with PTPRC: view

Human Phenotype Ontology for PTPRC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPRC Gene

MGI Knock Outs for PTPRC:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PTPRC Gene

Localization for PTPRC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRC Gene

Membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRC Gene COMPARTMENTS Subcellular localization image for PTPRC gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 3
nucleus 3
cytosol 2
peroxisome 2
vacuole 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA,ISS --
GO:0070062 extracellular exosome IDA 12519789
genes like me logo Genes that share ontologies with PTPRC: view

Pathways & Interactions for PTPRC Gene

genes like me logo Genes that share pathways with PTPRC: view

SIGNOR curated interactions for PTPRC Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PTPRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001915 negative regulation of T cell mediated cytotoxicity ISS --
GO:0001960 negative regulation of cytokine-mediated signaling pathway ISS --
GO:0002378 immunoglobulin biosynthetic process IMP 1793833
GO:0006469 negative regulation of protein kinase activity ISS --
GO:0006470 protein dephosphorylation IEA,ISS --
genes like me logo Genes that share ontologies with PTPRC: view

Drugs & Compounds for PTPRC Gene

(29) Drugs for PTPRC Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adalimumab Approved Pharma 443
Etanercept Approved, Investigational Pharma 383
Infliximab Approved Pharma 349
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0

(43) Additional Compounds for PTPRC Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTPRC: view

Transcripts for PTPRC Gene

Unigene Clusters for PTPRC Gene

Protein tyrosine phosphatase, receptor type, C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRC Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5: - - - - - -
SP6: - - -
SP7: - - - - -
SP8: - - - -
SP9: - -
SP10: - - - - - -
SP11: - -
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29a · 29b ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b ^
SP1:
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for PTPRC Gene

GeneLoc Exon Structure for
PTPRC
ECgene alternative splicing isoforms for
PTPRC

Expression for PTPRC Gene

mRNA expression in normal human tissues for PTPRC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRC Gene

This gene is overexpressed in Whole Blood (x30.3) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for PTPRC Gene

This gene is overexpressed in Tlymphocyte (17.0), Lymph node (12.3), CD8 Tcells (6.9), and Monocytes (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PTPRC Gene



SOURCE GeneReport for Unigene cluster for PTPRC Gene Hs.654514

genes like me logo Genes that share expression patterns with PTPRC: view

Protein tissue co-expression partners for PTPRC Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PTPRC Gene

Orthologs for PTPRC Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPRC 35
  • 99.03 (n)
  • 98.47 (a)
PTPRC 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPRC 36
  • 65 (a)
OneToOne
PTPRC 35
  • 74.32 (n)
  • 69.07 (a)
dog
(Canis familiaris)
Mammalia PTPRC 35
  • 79.77 (n)
  • 70.94 (a)
PTPRC 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprc 36
  • 68 (a)
OneToOne
Ptprc 16
Ptprc 35
  • 74.86 (n)
  • 69.58 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPRC 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 9 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ptprc 35
  • 74.22 (n)
  • 67.69 (a)
chicken
(Gallus gallus)
Aves PTPRC 36
  • 51 (a)
OneToOne
PTPRC 35
  • 62.91 (n)
  • 55.3 (a)
lizard
(Anolis carolinensis)
Reptilia PTPRC 36
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ptprc-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprc 35
  • 60.57 (n)
  • 53.23 (a)
zebrafish
(Danio rerio)
Actinopterygii ptprc 36
  • 38 (a)
OneToOne
Dr.12536 35
ptprc 35
  • 56.1 (n)
  • 46.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 37
  • 45 (a)
Ptp69D 37
  • 37 (a)
Ptp69D 36
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C02B10.6 37
  • 38 (a)
C17H12.3 37
  • 34 (a)
C55B7.3 37
  • 30 (a)
F36H12.10 37
  • 38 (a)
F47B3.1 37
  • 34 (a)
F47B3.6 37
  • 34 (a)
F47B3.7 37
  • 36 (a)
M04G7.2 37
  • 33 (a)
T22C1.8 37
  • 33 (a)
T27A3.5 37
  • 35 (a)
ZK616.7 37
  • 34 (a)
clr-1 36
  • 19 (a)
OneToOne
Species with no ortholog for PTPRC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRC Gene

ENSEMBL:
Gene Tree for PTPRC (if available)
TreeFam:
Gene Tree for PTPRC (if available)

Paralogs for PTPRC Gene

Paralogs for PTPRC Gene

genes like me logo Genes that share paralogs with PTPRC: view

Variants for PTPRC Gene

Sequence variations from dbSNP and Humsavar for PTPRC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs874909 -- 198,750,844(+) TTGCA(C/T)GCTGC intron-variant
rs1058191 -- 198,756,040(+) GCTAA(C/T)TGTGT reference, synonymous-codon
rs1011338 -- 198,723,235(-) TAACC(A/G)GTAGA intron-variant
rs1052240 -- 198,665,685(+) CCTTT(A/C)CTTGG intron-variant
rs1926232 -- 198,638,450(+) CATTA(G/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PTPRC Gene

Variant ID Type Subtype PubMed ID
nsv873080 CNV Gain 21882294
esv2721206 CNV Deletion 23290073
nsv819406 CNV Loss 19587683

Variation tolerance for PTPRC Gene

Residual Variation Intolerance Score: 8.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRC Gene

HapMap Linkage Disequilibrium report
PTPRC
Human Gene Mutation Database (HGMD)
PTPRC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRC Gene

Disorders for PTPRC Gene

MalaCards: The human disease database

(88) MalaCards diseases for PTPRC Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive
  • severe combined immunodeficiency, t-cell negative, b-cell/natural killer cell-positive type
hepatitis c virus
  • hepatitic c virus
t-b+ severe combined immunodeficiency due to cd45 deficiency
  • t-b+ scid due to cd45 deficiency
malignant histiocytosis
  • histiocytic medullary reticulosis [obs]
severe combined immune deficiency, autosomal recessive t cell-negative, b cell-positive, nk cell-positive, ptprc-related
  • severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive
- elite association - COSMIC cancer census association via MalaCards
Search PTPRC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PTPRC_HUMAN
  • Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. {ECO:0000269 PubMed:11145714}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. {ECO:0000269 PubMed:11101853}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for PTPRC

Genetic Association Database (GAD)
PTPRC
Human Genome Epidemiology (HuGE) Navigator
PTPRC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRC
genes like me logo Genes that share disorders with PTPRC: view

No data available for Genatlas for PTPRC Gene

Publications for PTPRC Gene

  1. A point mutation in PTPRC is associated with the development of multiple sclerosis. (PMID: 11101853) Jacobsen M. … Hemmer B. (Nat. Genet. 2000) 3 4 23 48 67
  2. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. (PMID: 2169617) Kaplan R. … Schlessinger J. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 23
  3. Expression of CD45 isoforms correlates with differential proliferative responses of peripheral CD4+ and CD8+ T cells. (PMID: 20093141) Seki I. … Kohsaka H. (Immunol. Lett. 2010) 3 23
  4. Dynamic regulation of CD45 lateral mobility by the spectrin-ankyrin cytoskeleton of T cells. (PMID: 20164196) Cairo C.W. … Golan D.E. (J. Biol. Chem. 2010) 3 23
  5. CD45 recruits adapter protein DOK-1 and negatively regulates JAK-STAT signaling in hematopoietic cells. (PMID: 19481264) Wu L. … Shen S.S. (Mol. Immunol. 2009) 3 23

Products for PTPRC Gene

Sources for PTPRC Gene

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