Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PTPRB Gene

protein-coding   GIFtS: 69
GCID: GC12M070910

Protein Tyrosine Phosphatase, Receptor Type, B


(Previous symbol: PTPB)
  See PTPRB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Protein Tyrosine Phosphatase, Receptor Type, B1 2     R-PTP-BETA2
PTPB1 2 3     VEPTP2
Vascular Endothelial Protein Tyrosine Phosphatase2 3     Protein Tyrosine Phosphatase, Receptor Type, Beta Polypeptide2
VE-PTP2 3     Receptor-Type Tyrosine-Protein Phosphatase Beta2
EC 3.1.3.483 8     R-PTP-beta3
HPTP-BETA2     Protein-Tyrosine Phosphatase Beta3
HPTPB2     

External Ids:    HGNC: 96651   Entrez Gene: 57872   Ensembl: ENSG000001273297   OMIM: 1768825   UniProtKB: P234673   

Export aliases for PTPRB gene to outside databases

Previous GC identifers: GC12M070786 GC12M070631 GC12M069201 GC12M067960


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PTPRB Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane
segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of
this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor
and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with
sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions
of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and
neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, May 2011)

GeneCards Summary for PTPRB Gene:
PTPRB (protein tyrosine phosphatase, receptor type, B) is a protein-coding gene. Diseases associated with PTPRB include hyperkalemic periodic paralysis. GO annotations related to this gene include transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRQ.

UniProtKB/Swiss-Prot: PTPRB_HUMAN, P23467
Function: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial
formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation
of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts
as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects
blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth.
Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin
in endothelial cells and this requires the presence of plakoglobin (By similarity)

Gene Wiki entry for PTPRB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPRB gene promoter:
         HFH-3   Sox5   AML1a   Olf-1   AP-4   GATA-2   E47   FOXI1   SRY   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPRB promoter sequence
   Search Chromatin IP Primers for PTPRB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15-q21   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15-q21

PTPRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPRB gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M070910:  view genomic region     (about GC identifiers)

Start:
70,910,630 bp from pter      End:
71,031,220 bp from pter
Size:
120,591 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PTPRB_HUMAN, P23467 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein phosphatase beta precursor  
Size: 1997 amino acids; 224301 Da
Subunit: Monomer. Interacts with TEK. Interacts via fibronectin type-III 17 domain with CDH5 (By similarity)
Selected PDB 3D structures from and Proteopedia for PTPRB (see all 12):
2AHS (3D)        2H02 (3D)        2H03 (3D)        2H04 (3D)        2HC1 (3D)        2HC2 (3D)    
Secondary accessions: B7ZKT0 C9JX87 Q14D85 Q3MIV7
Alternative splicing: 3 isoforms:  P23467-1   P23467-2   P23467-3   

Explore the universe of human proteins at neXtProt for PTPRB: NX_P23467

Explore proteomics data for PTPRB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn28, Asn53, Asn75, Asn172, Asn198, Asn267, Asn321, Asn414, Asn421, Asn479,
                                 Asn544, Asn574, Asn598, Asn652, Asn721, Asn829, Asn1040, Asn1096, Asn1163, Asn1185 (see all 26)
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for PTPRB (P23467)
     VVHCSAG  WPDHGVP  VHCSAGVGRTG 


    See PTPRB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001103224.1  NP_001193900.1  NP_001193901.1  NP_002828.3  

    ENSEMBL proteins: 
     ENSP00000334928   ENSP00000448058   ENSP00000438927   ENSP00000447302   ENSP00000261266  
     ENSP00000448349   ENSP00000446982   ENSP00000446934   ENSP00000393028  

    PTPRB Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PTPRB Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PTPRB
    OriGene Purified Protein for PTPRB
    OriGene Protein Over-expression Lysate for PTPRB
    OriGene MassSpec for PTPRB
    OriGene Custom Protein Services for PTPRB
    GenScript Custom Purified and Recombinant Proteins Services for PTPRB
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTPRB

     
    Search eBioscience for Proteins for PTPRB 

     
    antibodies-online proteins for PTPRB (2 products) 

     
    Search antibodies-online for peptides for PTPRB

    PTPRB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PTPRB
    OriGene Custom Antibody Services for PTPRB
    Novus Biologicals PTPRB Antibodies
    Search for Antibodies for PTPRB at Abcam
    Cloud-Clone Corp. Antibodies for PTPRB
    ThermoFisher Antibodies for PTPRB
    antibodies-online antibodies for PTPRB (38 products) 

    PTPRB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTPRB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTPRB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTPRB
    Cloud-Clone Corp. CLIAs for PTPRB
    Search eBioscience for ELISAs for PTPRB 
    antibodies-online kits for PTPRB (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    PTPR: Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like

    IUPHAR Guide to PHARMACOLOGY protein family classification: Type B
    Receptor tyrosine phosphatases (RTP)

    5 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR016130 Tyr_Pase_AS
     IPR013783 Ig-like_fold
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry P23467

    ProtoNet protein and cluster: P23467

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTPRB_HUMAN, P23467
    Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily
    Similarity: Contains 17 fibronectin type-III domains
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPRB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTPRB_HUMAN, P23467
    Function: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial
    formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation
    of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts
    as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects
    blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth.
    Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin
    in endothelial cells and this requires the presence of plakoglobin (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Induction: Up-regulated by hypoxia

         Genatlas biochemistry entry for PTPRB:
    protein tyrosine phosphatase,receptor-type,beta polypeptide

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0005001transmembrane receptor protein tyrosine phosphatase activity TAS2170109
    GO:0005515protein binding IPI12840032
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with PTPRB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PTPRB:
     Increased Akt phosphorylation  

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ptprb):
     cardiovascular system  embryogenesis  growth/size/body  homeostasis/metabolism  integument 
     mortality/aging  muscle 

    Find genes that share phenotypes with PTPRB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ptprbtm1Lex for PTPRB

       genOway: Develop your customized and physiologically relevant rodent model for PTPRB

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTPRB:
    hsa-mir-124-3p (MIRT022308)

    Block miRNA regulation of human, mouse, rat PTPRB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPRB (see all 61):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-128 hsa-miR-105 hsa-miR-890 hsa-miR-889 hsa-miR-23a hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidPTPRB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PTPRB
    Predesigned siRNA for gene silencing in human, mouse, rat PTPRB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTPRB

    Clone
    Products:
         
    OriGene clones in human, mouse for PTPRB (see all 9)
    OriGene ORF clones in mouse, rat for PTPRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PTPRB (NM_002837)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRB
    Addgene plasmids for PTPRB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PTPRB
    Browse ESI BIO Cell Lines and PureStem Progenitors for PTPRB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PTPRB_HUMAN, P23467: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS2170109
    GO:0043235receptor complex IDA--

    Find genes that share ontologies with PTPRB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PTPRB About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2TWEAK Pathway
    Apoptotic Pathways Triggered By HIV10.42
    3PAK Pathway
    Epithelial Adherens Junctions0.36
    4Adherens junction
    Adherens junction


    Find genes that share SuperPaths with PTPRB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PTPRB (see all 6)
        Activation of PKA through GPCR
    PKA Signaling
    Apoptotic Pathways Triggered By HIV1
    cAMP Pathway
    Activation of cAMP-Dependent PKA


    1 Kegg Pathway  (Kegg details for PTPRB):
        Adherens junction

        Pathway & Disease-focused RT2 Profiler PCR Array including PTPRB: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPRB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTPRB (P234671, 2, 3 ENSP000003349284) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GHRP109121, 2, 3, ENSP000002308824EBI-1265766,EBI-286316 MINT-6797788 MINT-6797562 I2D: score=3 STRING: ENSP00000230882
    METP085811, 2, 3, ENSP000003172724EBI-1265766,EBI-1039152 MINT-8217189 MINT-8217090 I2D: score=2 STRING: ENSP00000317272
    FLT1P179482, 3, ENSP000002823974MINT-8277647 MINT-8277600 I2D: score=1 STRING: ENSP00000282397
    TEKQ027631, 3, ENSP000003839774EBI-1265766,EBI-2257090 I2D: score=2 STRING: ENSP00000383977
    ERBB2P046261, 3, ENSP000002695714EBI-1265766,EBI-641062 I2D: score=1 STRING: ENSP00000269571
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006470protein dephosphorylation TAS2170109
    GO:0006796phosphate-containing compound metabolic process TAS2170109
    GO:0016311dephosphorylation IDA19116766
    GO:0035335peptidyl-tyrosine dephosphorylation TAS2170109

    Find genes that share ontologies with PTPRB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPRB

    1 HMDB Compound for PTPRB    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    4 DrugBank Compounds for PTPRB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (4-ETHYLPHENYL)SULFAMIC ACID-- --target--10592235
    (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID-- --target--10592235
    {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID-- --target--10592235
    {4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID-- --target--10592235

    5 Novoseek inferred chemical compound relationships for PTPRB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurocan 82.1 3 8663515 (1), 9507007 (1), 9182584 (1)
    tyrosine 69.8 66 10769382 (4), 11313993 (2), 15725399 (2), 11520897 (2) (see all 34)
    chondroitin sulfate 57.6 3 9660874 (1), 12242104 (1)
    phosphatidylinositol 10 2 11707406 (1)
    sodium 4.65 7 10769382 (4), 11779698 (1)



    Find genes that share compounds with PTPRB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PTPRB gene (4 alternative transcripts): 
    NM_001109754.2  NM_001206971.1  NM_001206972.1  NM_002837.4  

    Unigene Cluster for PTPRB:

    Protein tyrosine phosphatase, receptor type, B
    Hs.434375  [show with all ESTs]
    Unigene Representative Sequence: NM_001109754
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334414(uc001swb.4 uc010sto.2 uc001swc.4 uc001swa.4 uc009zrr.2)
    ENST00000550358 ENST00000538708 ENST00000550857 ENST00000261266 ENST00000549400
    ENST00000551525(uc001swd.4) ENST00000548122 ENST00000538174 ENST00000552253(uc001swe.3)
    ENST00000547715 ENST00000451516(uc010stp.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PTPRB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPRB (see all 61):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-128 hsa-miR-105 hsa-miR-890 hsa-miR-889 hsa-miR-23a hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidPTPRB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PTPRB
    Predesigned siRNA for gene silencing in human, mouse, rat PTPRB
    Clone
    Products:
         
    OriGene clones in human, mouse for PTPRB (see all 9)
    OriGene ORF clones in mouse, rat for PTPRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PTPRB (NM_002837)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRB
    Addgene plasmids for PTPRB 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PTPRB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPRB
      QuantiTect SYBR Green Assays in human, mouse, rat PTPRB
      QuantiFast Probe-based Assays in human, mouse, rat PTPRB

    Additional mRNA sequence: 

    AK023720.1 AK096717.1 AK097371.1 AK126121.1 AK128562.1 AL080103.1 BC043182.2 BC051329.1 
    BC101679.1 BC113463.1 BC143356.1 BC143360.1 BX647238.1 BX648245.1 BX648771.1 CR749546.1 
    X54131.1 

    12 DOTS entries:

    DT.91989557  DT.100739214  DT.100727943  DT.91818683  DT.121129892  DT.91864148  DT.91820765  DT.95097096 
    DT.99963425  DT.101960359  DT.100730866  DT.40192712 

    Selected AceView cDNA sequences (see all 91):

    AI215514 AK097371 AK023720 AW299801 BM993516 AW299809 AK126121 BF438283 
    AI424830 BC051329 BQ710210 CK299423 AW614378 AW188237 AW614544 AW665423 
    BX648245 CA435694 AI420494 AI373737 AI783646 BM993955 AI539312 BQ706085 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTPRB (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^
    SP1:                    -     -                                   -                 -                                                                           
    SP2:                                                              -                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for PTPRB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PTPRB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTPRB Expression
    About this image


    PTPRB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human umbilical vein endothelial cells (HUVEC)
             Endothelial-like cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
    PTPRB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPRB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434375
        Pathway & Disease-focused RT2 Profiler PCR Array including PTPRB: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PTPRB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPRB
    QuantiTect SYBR Green Assays in human, mouse, rat PTPRB
    QuantiFast Probe-based Assays in human, mouse, rat PTPRB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PTPRB gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptprb1 , 5 protein tyrosine phosphatase, receptor type, B1, 5 84.93(n)1
    86.01(a)1
      10 (64.68 cM)5
    192631  NM_029928.21  NP_084204.21 
     1163013745 
    chicken
    (Gallus gallus)
    Aves PTPRB1 protein tyrosine phosphatase, receptor type, B 70.7(n)
    69.17(a)
      417853  XM_416095.4  XP_416095.4 
    lizard
    (Anolis carolinensis)
    Reptilia PTPRB6
    protein tyrosine phosphatase, receptor type, B
    66(a)
    1 ↔ 1
    5(37885660-37979490)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.127132 Transcribed sequence with moderate similarity to protein more 79.32(n)    BX717895.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.123452 Transcribed sequence with weak similarity to protein more 75.19(n)    CF999770.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ptp52F3
    Ptp10D1
    axon guidance protein tyrosine
    phosphatase3
    Protein tyrosine phosphatase 10D1
    40(a)
    (best of 3)3
    44.94(n)1
    34.88(a)1
      52F33
    321151  NM_001144715.21  NP_001138187.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48G9A.93   -- 34(a)
    (best of 6)
      III(2164580-2171451)   --


    ENSEMBL Gene Tree for PTPRB (if available)
    TreeFam Gene Tree for PTPRB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PTPRB gene
    PTPRQ2  PTPRJ2  PTPN72  PTPRH2  PTPN52  PTPRO2  PTPRR2  
    Selected SIMAP similar genes for PTPRB using alignment to 9 protein entries:     PTPRB_HUMAN (see all proteins) (see all similar genes):
    DKFZp686E13109    DKFZp686H15164    DKFZp686E2262    DKFZp313F1310    PTPRK    PTPN1
    PTPRS    PTPN7    DKFZp566K0524    PTN2    PTPN20A    PTPN20B
    PTPN5    PTPRR    PTPN2    BPTP-2    BPTP-3    DKFZp761A0712

    Find genes that share paralogs with PTPRB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PTPRB (see all 2516)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs786429561,2
    C--67966089(+) AAAAA-/TWAGAA 4 -- int10--------
    rs340121311,2
    C--67985041(+) ACTTTC/-TGTGT 4 -- int12Minor allele frequency- -:0.25NA 4
    rs1442545851,2
    C--67985959(+) TCTTG-/AAAAAA 4 -- int10--------
    rs2017951951,2
    C--67990903(+) CTTCC-/TTTTTTT 4 -- int10--------
    rs556729071,2
    C--67990921(+) TTTTT-/T/TT  
            
    GAGAC
    4 -- int11NA 2
    rs2015756051,2
    C--68016640(+) TTTTC-/TTTTCT
            
    TTTTT
    4 -- int10--------
    rs1119561051,2
    C--68016916(+) GGGGAG/-TGCAT 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs57989941,2
    C--68021573(+) TTTCCT/-CCTTT 4 -- int1 trp31Minor allele frequency- -:0.00CSA 2
    rs105581401,2
    C--68031238(+) aaaaa-/A/AAAA
            
    aaaaa
    4 -- int11NA 2
    rs348272271,2
    C--68041406(+) AGTTTC/-CTCAT 4 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for PTPRB (70910630 - 71031220 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PTPRB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509472CNV Insertion20534489
    esv271661CNV Insertion20981092
    nsv820183CNV Loss19587683
    esv32743CNV Gain17666407
    nsv518144CNV Gain19592680
    nsv8986CNV Gain+Loss18304495

    Human Gene Mutation Database (HGMD): PTPRB
    2 Site Specific Mutation Identification with PCR Assays for PTPRB:
    Cosmic IdAA Change
    142728p.S452I
    142730p.S452R
    SeqTarget long-range PCR primers for resequencing PTPRB
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPRB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 176882    OMIM disorders: --

    1 disease for PTPRB:    
    About MalaCards
    hyperkalemic periodic paralysis

    1 disease from the University of Copenhagen DISEASES database for PTPRB:
    Hyperkalemic periodic paralysis

    Find genes that share disorders with PTPRB           About GenesLikeMe

    6 Novoseek inferred disease relationships for PTPRB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 52 10 15831233 (4), 16923162 (2), 16489031 (2), 14692702 (1)
    glioma 40.7 5 11313993 (2), 15831233 (1)
    astrocytoma 36.1 1 11313993 (1)
    intoxication 12.2 1 15671482 (1)
    tumors 0 6 16489031 (3), 15831233 (2)
    cancer 0 3 15831233 (1), 16489031 (1)

    Genetic Association Database (GAD): PTPRB
    Human Genome Epidemiology (HuGE) Navigator: PTPRB (4 documents)

    Export disorders for PTPRB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PTPRB gene, integrated from 10 sources (see all 87):
    (articles sorted by number of sources associating them with PTPRB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells. (PubMed id 19116766)1, 2, 9 Yacyshyn O.K.... Stewart D.J. (Angiogenesis 2009)
    2. Association of PTPRB gene polymorphism with drug addiction. (PubMed id 18361428)1, 4, 9 Ishiguro H....Uhl G.R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)1, 2 Barr A.J.... Knapp S. (Cell 2009)
    6. VE-PTP controls blood vessel development by balancing Tie-2 activity. (PubMed id 19451274)1, 2 Winderlich M.... Vestweber D. (J. Cell Biol. 2009)
    7. Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis. (PubMed id 19136612)1, 2 Mellberg S.... Claesson-Welsh L. (FASEB J. 2009)
    8. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    9. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. (PubMed id 2169617)1, 3 Kaplan R.... Schlessinger J. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    10. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. (PubMed id 2170109)1, 2 Krueger N.X.... Saito H. (EMBO J. 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5787 HGNC: 9665 AceView: PTPRB Ensembl:ENSG00000127329 euGenes: HUgn5787
    ECgene: PTPRB Kegg: 5787 H-InvDB: PTPRB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PTPRB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPRB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PTPRB gene:
    Search GeneIP for patents involving PTPRB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant PTPRB Protein
     Browse Kits and Assays available from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PTPRB   OriGene RNAi products in human, mouse, rat for PTPRB  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PTPRB  
     OriGene MassSpec for PTPRB   OriGene clones in human, mouse for PTPRB  
     OriGene qSTAR qPCR primer pairs in human, mouse for PTPRB   OriGene Purified Protein for PTPRB  
     OriGene ORF clones in mouse, rat for PTPRB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PTPRB   OriGene Custom Protein Services for PTPRB  

     
     
     Block miRNA regulation of human, mouse, rat PTPRB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PTPRB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPRB Predesigned siRNA for gene silencing in human, mouse, rat PTPRB
     QuantiFast Probe-based Assays in human, mouse, rat PTPRB QuantiTect SYBR Green Assays in human, mouse, rat PTPRB
     PCR Arrays including human, mouse, rat PTPRB Search Chromatin IP Primers for PTPRB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPRB  GeneGlobe Interaction Network for PTPRB
     Regulatory tfbs in PTPRB promoter
     GenScript Custom Purified and Recombinant Proteins Services for PTPRB GenScript cDNA clones with any tag delivered in your preferred vector for PTPRB
     GenScript Custom Assay Services for PTPRB GenScript Custom overexpressing Cell Line Services for PTPRB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PTPRB
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for PTPRB
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PTPRB antibodies
     Search for Antibodies for PTPRB at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PTPRB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PTPRB
     Antibodies for PTPRB
     ELISAs for PTPRB
     CLIAs for PTPRB



     Browse ESI BIO Cell Lines and PureStem Progenitors for PTPRB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPRB
     SwitchGear 3'UTR luciferase reporter plasmids for PTPRB
     SwitchGear Promoter luciferase reporter plasmids for PTPRB
     ThermoFisher Antibodies for PTPRB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPRB
     Browse compounds at ApexBio
     Addgene plasmids for PTPRB
      Search eBioscience for proteins for PTPRB
      Search eBioscience for elisas for PTPRB
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PTPRB
     antibodies-online antibodies for PTPRB (38 products)
     antibodies-online kits for PTPRB (4 products)
      Search antibodies-online for peptides for PTPRB
     antibodies-online proteins for PTPRB (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PTPRB gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4