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Aliases for PTPRB Gene

Aliases for PTPRB Gene

  • Protein Tyrosine Phosphatase, Receptor Type B 2 3
  • Vascular Endothelial Protein Tyrosine Phosphatase 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, B 3 5
  • EC 3.1.3.48 4 63
  • R-PTP-BETA 3 4
  • VE-PTP 3 4
  • PTPB 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, Beta Polypeptide 3
  • Protein-Tyrosine Phosphatase Beta 4
  • HPTP-BETA 3
  • HPTPB 3
  • VEPTP 3

External Ids for PTPRB Gene

Previous HGNC Symbols for PTPRB Gene

  • PTPB

Previous GeneCards Identifiers for PTPRB Gene

  • GC12M070786
  • GC12M070631
  • GC12M069201
  • GC12M070910
  • GC12M067960

Summaries for PTPRB Gene

Entrez Gene Summary for PTPRB Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for PTPRB Gene

PTPRB (Protein Tyrosine Phosphatase, Receptor Type B) is a Protein Coding gene. Diseases associated with PTPRB include Hyperkalemic Periodic Paralysis, Type 2 and Familial Periodic Paralysis. Among its related pathways are TWEAK Pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRO.

UniProtKB/Swiss-Prot for PTPRB Gene

  • Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

Gene Wiki entry for PTPRB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRB Gene

Genomics for PTPRB Gene

Regulatory Elements for PTPRB Gene

Enhancers for PTPRB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTPRB on UCSC Golden Path with GeneCards custom track

Promoters for PTPRB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTPRB on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPRB Gene

Chromosome:
12
Start:
70,515,866 bp from pter
End:
70,637,440 bp from pter
Size:
121,575 bases
Orientation:
Minus strand

Genomic View for PTPRB Gene

Genes around PTPRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRB Gene

Proteins for PTPRB Gene

  • Protein details for PTPRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23467-PTPRB_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase beta
    Protein Accession:
    P23467
    Secondary Accessions:
    • B7ZKS8
    • B7ZKT0
    • C9JX87
    • F5H3G6
    • Q14D85
    • Q3MIV7

    Protein attributes for PTPRB Gene

    Size:
    1997 amino acids
    Molecular mass:
    224301 Da
    Quaternary structure:
    • Monomer. Interacts with TEK (PubMed:19451274). Interacts via fibronectin type-III 17 domain with CDH5. Detected in a complex with CNTN1 and NRCAM (By similarity).

    Three dimensional structures from OCA and Proteopedia for PTPRB Gene

    Alternative splice isoforms for PTPRB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRB Gene

Proteomics data for PTPRB Gene at MOPED

Selected DME Specific Peptides for PTPRB Gene

Post-translational modifications for PTPRB Gene

  • Glycosylation at Asn 28, Asn 53, Asn 75, Asn 172, Asn 198, Asn 267, Asn 321, Asn 414, Asn 421, Asn 479, Asn 544, Asn 574, Asn 598, Asn 652, Asn 721, Asn 829, Asn 1040, Asn 1096, Asn 1163, Asn 1185, Asn 1212, Asn 1274, Asn 1367, Asn 1470, Asn 1474, and Asn 1518
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for PTPRB Gene

Graphical View of Domain Structure for InterPro Entry

P23467

UniProtKB/Swiss-Prot:

PTPRB_HUMAN :
  • Contains 17 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
Domain:
  • Contains 17 fibronectin type-III domains.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
genes like me logo Genes that share domains with PTPRB: view

Function for PTPRB Gene

Molecular function for PTPRB Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type,beta polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by hypoxia.

Enzyme Numbers (IUBMB) for PTPRB Gene

Gene Ontology (GO) - Molecular Function for PTPRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 2170109
genes like me logo Genes that share ontologies with PTPRB: view
genes like me logo Genes that share phenotypes with PTPRB: view

Animal Models for PTPRB Gene

MGI Knock Outs for PTPRB:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPRB

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRB Gene

Localization for PTPRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRB Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRB Gene COMPARTMENTS Subcellular localization image for PTPRB gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PTPRB Gene

Pathways & Interactions for PTPRB Gene

genes like me logo Genes that share pathways with PTPRB: view

Pathways by source for PTPRB Gene

SIGNOR curated interactions for PTPRB Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PTPRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,TAS 2170109
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 2170109
genes like me logo Genes that share ontologies with PTPRB: view

Drugs & Compounds for PTPRB Gene

(5) Drugs for PTPRB Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID Experimental Pharma Target 0
(4-ETHYLPHENYL)SULFAMIC ACID Experimental Pharma Target 0
{4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID Experimental Pharma Target 0
{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID Experimental Pharma Target 0

(7) Additional Compounds for PTPRB Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTPRB: view

Transcripts for PTPRB Gene

Unigene Clusters for PTPRB Gene

Protein tyrosine phosphatase, receptor type, B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRB Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^
SP1: - - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for PTPRB Gene

GeneLoc Exon Structure for
PTPRB
ECgene alternative splicing isoforms for
PTPRB

Expression for PTPRB Gene

mRNA expression in normal human tissues for PTPRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPRB Gene

This gene is overexpressed in Platelet (32.5), Liver (13.5), and Pancreatic juice (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTPRB Gene



SOURCE GeneReport for Unigene cluster for PTPRB Gene Hs.434375

genes like me logo Genes that share expression patterns with PTPRB: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PTPRB Gene

Orthologs for PTPRB Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRB 35
  • 88.48 (n)
  • 87.24 (a)
PTPRB 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRB 35
  • 87.8 (n)
  • 87.9 (a)
PTPRB 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprb 35
  • 84.93 (n)
  • 86.01 (a)
Ptprb 16
Ptprb 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPRB 35
  • 98.37 (n)
  • 97.78 (a)
PTPRB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprb 35
  • 84.63 (n)
  • 84.85 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPRB 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRB 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRB 35
  • 70.7 (n)
  • 69.17 (a)
PTPRB 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRB 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprb 35
  • 65.08 (n)
  • 64.31 (a)
Str.12713 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12345 35
ptprb 35
  • 53.46 (n)
  • 46.27 (a)
ptprb 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ptp10D 37
  • 28 (a)
Ptp4E 37
  • 29 (a)
Ptp52F 37
  • 40 (a)
Ptp10D 35
  • 44.94 (n)
  • 34.88 (a)
Ptp10D 36
  • 28 (a)
ManyToMany
Ptp4E 36
  • 25 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004246 35
  • 43.17 (n)
  • 33.31 (a)
worm
(Caenorhabditis elegans)
Secernentea B0207.1 37
  • 32 (a)
F47B3.1 37
  • 30 (a)
F47B3.6 37
  • 30 (a)
T27A3.5 37
  • 30 (a)
Y48G9A.9 37
  • 34 (a)
ZK354.8 37
  • 34 (a)
dep-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5519 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.962 36
  • 55 (a)
OneToOne
Species with no ortholog for PTPRB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRB Gene

ENSEMBL:
Gene Tree for PTPRB (if available)
TreeFam:
Gene Tree for PTPRB (if available)

Paralogs for PTPRB Gene

genes like me logo Genes that share paralogs with PTPRB: view

Variants for PTPRB Gene

Sequence variations from dbSNP and Humsavar for PTPRB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs36027530 - 70,590,176(+) TCACT(A/G)CAAGA intron-variant, nc-transcript-variant, reference, missense
rs2165627 - 70,590,115(-) AATGA(G/T)TCTGT intron-variant, nc-transcript-variant, reference, missense
VAR_057137 -
VAR_057138 -
VAR_057139 -

Structural Variations from Database of Genomic Variants (DGV) for PTPRB Gene

Variant ID Type Subtype PubMed ID
nsv8986 CNV Gain+Loss 18304495
esv32743 CNV Gain 17666407
nsv509472 CNV Insertion 20534489
nsv820183 CNV Loss 19587683
esv271661 CNV Insertion 20981092
nsv518144 CNV Gain 19592680

Variation tolerance for PTPRB Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.17; 97.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRB Gene

Human Gene Mutation Database (HGMD)
PTPRB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRB Gene

Disorders for PTPRB Gene

MalaCards: The human disease database

(2) MalaCards diseases for PTPRB Gene - From: DISEASES

Disorder Aliases PubMed IDs
hyperkalemic periodic paralysis, type 2
  • hyperkalemic periodic paralysis
familial periodic paralysis
  • paralyses, familial periodic
- elite association - COSMIC cancer census association via MalaCards
Search PTPRB in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPRB

Genetic Association Database (GAD)
PTPRB
Human Genome Epidemiology (HuGE) Navigator
PTPRB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRB
genes like me logo Genes that share disorders with PTPRB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRB Gene

Publications for PTPRB Gene

  1. Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells. (PMID: 19116766) Yacyshyn O.K. … Stewart D.J. (Angiogenesis 2009) 3 4 23 67
  2. Association of PTPRB gene polymorphism with drug addiction. (PMID: 18361428) Ishiguro H. … Uhl G.R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23
  3. Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins. (PMID: 12615970) Adamsky K. … Peles E. (J. Cell. Sci. 2003) 3 23
  4. Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth. (PMID: 12700241) Garwood J. … Faissner A. (J. Biol. Chem. 2003) 3 23
  5. Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C. (PMID: 11313993) Adamsky K. … Peles E. (Oncogene 2001) 3 23

Products for PTPRB Gene

Sources for PTPRB Gene

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