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Aliases for PTPRA Gene

Aliases for PTPRA Gene

  • Protein Tyrosine Phosphatase, Receptor Type A 2 3 5
  • Protein-Tyrosine Phosphatase Alpha 3 4
  • R-PTP-Alpha 3 4
  • EC 4 61
  • PTPRL2 3 4
  • PTPA 3 4
  • Leukocyte Common Antigen-Related Peptide (Protein Tyrosine Phosphate) 3
  • Protein Tyrosine Phosphatase, Receptor Type, Alpha Polypeptide 3
  • Receptor-Type Tyrosine-Protein Phosphatase Alpha 3
  • PTPLCA-Related Phosphatase 3
  • Tyrosine Phosphatase Alpha 3
  • PTPase-Alpha 3
  • HPTPalpha 3
  • HEPTP 3
  • HPTPA 3
  • RPTPA 3
  • HLPR 3
  • LRP 3

External Ids for PTPRA Gene

Previous HGNC Symbols for PTPRA Gene

  • PTPRL2
  • PTPA

Previous GeneCards Identifiers for PTPRA Gene

  • GC20P002809
  • GC20P002816
  • GC20P002770
  • GC20P002771
  • GC20P002772
  • GC20P002793
  • GC20P002794
  • GC20P002795
  • GC20P002796
  • GC20P002797
  • GC20P002844

Summaries for PTPRA Gene

Entrez Gene Summary for PTPRA Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRA Gene

PTPRA (Protein Tyrosine Phosphatase, Receptor Type A) is a Protein Coding gene. Diseases associated with PTPRA include Estrogen-Receptor Negative Breast Cancer. Among its related pathways are RET signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRE.

Gene Wiki entry for PTPRA Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRA Gene

Genomics for PTPRA Gene

Regulatory Elements for PTPRA Gene

Enhancers for PTPRA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F002831 0.6 Ensembl ENCODE 12 -31.9 -31865 1.4 JUN ZBTB40 ZNF316 NFE2 TRIM24 FOS FOSL2 NFE2L2 SMARCE1 ZNF362 PTPRA MRPS26 GC20P002838 VPS16
GH20F002898 1.3 Ensembl ENCODE 11.8 +36.4 36417 4.0 ZNF121 OSR2 KLF1 ZBTB33 VPS16 MRPS26 PTPRA PCED1A GNRH2 TMEM239 C20orf141 ENSG00000241690 ITPA GC20M002886
GH20F002768 1.2 Ensembl ENCODE 11.8 -95.6 -95594 1.2 ZNF687 HCFC1 SUZ12 NR3C1 DPF2 MNT RAD21 JUND PBX2 CPXM1 VPS16 PTPRA C20orf141 ENSG00000241690 TMEM239 PCED1A RPL19P1 PIR31974
GH20F002771 0.2 Ensembl 11.8 -92.5 -92483 0.2 CTCF PKNOX1 SIN3A MAX ZIC2 ZNF335 ZFHX2 POLR2A MAZ NRF1 CPXM1 VPS16 PTPRA TMEM239 C20orf141 ENSG00000241690 PCED1A RPL19P1 PIR31974
GH20F002884 0.7 Ensembl 11.7 +20.6 20618 1.2 CTCF PKNOX1 MAZ ZNF654 JUNB ZNF140 TBX21 RAD21 ZNF316 TARDBP VPS16 ZNF343 PTPRA TMEM239 C20orf141 ENSG00000241690 GC20M002886
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PTPRA on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPRA Gene

2,864,184 bp from pter
3,039,076 bp from pter
174,893 bases
Plus strand

Genomic View for PTPRA Gene

Genes around PTPRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRA Gene

Proteins for PTPRA Gene

  • Protein details for PTPRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-type tyrosine-protein phosphatase alpha
    Protein Accession:
    Secondary Accessions:
    • A8K2G8
    • D3DVX5
    • Q14513
    • Q7Z2I2
    • Q96TD9

    Protein attributes for PTPRA Gene

    802 amino acids
    Molecular mass:
    90600 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PTPRA Gene


neXtProt entry for PTPRA Gene

Selected DME Specific Peptides for PTPRA Gene


Post-translational modifications for PTPRA Gene

  • Glycosylation at Asn 21, Asn 36, Asn 68, Asn 80, Asn 86, Asn 104, and Asn 124
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTPRA (PTPRA)
  • Cloud-Clone Corp. Antibodies for PTPRA

Domains & Families for PTPRA Gene

Gene Families for PTPRA Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 tyrosine-protein phosphatase domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
  • Contains 2 tyrosine-protein phosphatase domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
genes like me logo Genes that share domains with PTPRA: view

Function for PTPRA Gene

Molecular function for PTPRA Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type IV,alpha polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

Enzyme Numbers (IUBMB) for PTPRA Gene

Gene Ontology (GO) - Molecular Function for PTPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,TAS 10748206
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 2169617
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 7518772
genes like me logo Genes that share ontologies with PTPRA: view
genes like me logo Genes that share phenotypes with PTPRA: view

Animal Models for PTPRA Gene

MGI Knock Outs for PTPRA:

Animal Model Products

miRNA for PTPRA Gene

miRTarBase miRNAs that target PTPRA

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTPRA

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPRA Gene

Localization for PTPRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PTPRA Gene COMPARTMENTS Subcellular localization image for PTPRA gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PTPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2169617
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTPRA: view

Pathways & Interactions for PTPRA Gene

SuperPathways for PTPRA Gene

SuperPathway Contained pathways
1 RET signaling
2 Activation of cAMP-Dependent PKA
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Immune System
genes like me logo Genes that share pathways with PTPRA: view

Pathways by source for PTPRA Gene

1 Sino Biological pathway for PTPRA Gene
2 Cell Signaling Technology pathways for PTPRA Gene
2 BioSystems pathways for PTPRA Gene

SIGNOR curated interactions for PTPRA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PTPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006468 protein phosphorylation IEA --
GO:0006470 protein dephosphorylation IEA --
GO:0007411 axon guidance TAS --
GO:0008286 insulin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with PTPRA: view

Drugs & Compounds for PTPRA Gene

(9) Drugs for PTPRA Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(4) Additional Compounds for PTPRA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with PTPRA: view

Transcripts for PTPRA Gene

Unigene Clusters for PTPRA Gene

Protein tyrosine phosphatase, receptor type, A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTPRA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: - - - - - -
SP15: -

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42a · 42b ^ 43a ·
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: - -
SP9: - -

ExUns: 43b ^ 44 ^ 45
SP7: -

Relevant External Links for PTPRA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPRA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPRA Gene

This gene is overexpressed in Breast (23.9), Peripheral blood mononuclear cells (8.2), and Heart (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTPRA Gene

Protein tissue co-expression partners for PTPRA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTPRA Gene:


SOURCE GeneReport for Unigene cluster for PTPRA Gene:

genes like me logo Genes that share expression patterns with PTPRA: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTPRA Gene

Orthologs for PTPRA Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTPRA 34 35
  • 99.58 (n)
(Canis familiaris)
Mammalia PTPRA 34 35
  • 93.77 (n)
(Bos Taurus)
Mammalia PTPRA 34 35
  • 93.01 (n)
(Rattus norvegicus)
Mammalia Ptpra 34
  • 91.05 (n)
(Mus musculus)
Mammalia Ptpra 34 16 35
  • 90.67 (n)
(Monodelphis domestica)
Mammalia PTPRA 35
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia PTPRA 35
  • 79 (a)
(Gallus gallus)
Aves PTPA 35
  • 85 (a)
  • 78.26 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpra 34
  • 74.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia ptpa-A-prov 34
(Danio rerio)
Actinopterygii ptpra 34 35
  • 71.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 36
  • 37 (a)
Ptp69D 36
  • 37 (a)
CG7180 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea M04G7.2 36
  • 37 (a)
ZK616.7 36
  • 37 (a)
T22C1.8 36
  • 36 (a)
F20H11.4 36
  • 30 (a)
ptp-3 35
  • 13 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4172 34
Species where no ortholog for PTPRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRA Gene

Gene Tree for PTPRA (if available)
Gene Tree for PTPRA (if available)

Paralogs for PTPRA Gene

Variants for PTPRA Gene

Sequence variations from dbSNP and Humsavar for PTPRA Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1016753 -- 2,909,074(+) CACAT(C/G)AAAAA intron-variant
rs1016754 -- 2,909,136(+) GTTAT(A/G)TGTAA intron-variant
rs10211798 -- 2,863,808(+) AGaga(A/G)agaaa intron-variant, upstream-variant-2KB
rs10211799 -- 2,863,823(+) AAAGA(A/G)AGAAA intron-variant, upstream-variant-2KB
rs10439583 -- 3,008,744(+) aaaaa(A/C)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRA Gene

Variant ID Type Subtype PubMed ID
dgv2205n106 CNV deletion 24896259
dgv268e215 CNV deletion 23714750
esv2207372 CNV deletion 18987734
esv2272134 CNV deletion 18987734
esv2369681 CNV deletion 18987734
esv2661520 CNV deletion 23128226
esv2664542 CNV deletion 23128226
esv2669632 CNV deletion 23128226
esv2722110 CNV deletion 23290073
esv2722111 CNV deletion 23290073
esv2722112 CNV deletion 23290073
esv2722113 CNV deletion 23290073
esv2722114 CNV deletion 23290073
esv2762056 CNV gain 21179565
esv3556735 CNV deletion 23714750
esv3645020 CNV gain 21293372
esv3645021 CNV loss 21293372
esv3645022 CNV loss 21293372
esv3645023 CNV gain 21293372
esv3645024 CNV loss 21293372
esv5581 CNV loss 19470904
esv994080 CNV gain 20482838
nsv1057187 CNV gain 25217958
nsv1057464 CNV gain 25217958
nsv1071299 CNV deletion 25765185
nsv1125837 CNV deletion 24896259
nsv1130766 CNV deletion 24896259
nsv1143131 CNV deletion 24896259
nsv1148763 CNV deletion 26484159
nsv1151978 CNV deletion 26484159
nsv179703 CNV deletion 16902084
nsv180455 CNV deletion 16902084
nsv180708 CNV deletion 16902084
nsv3262 CNV insertion 18451855
nsv3263 CNV insertion 18451855
nsv478162 CNV novel sequence insertion 20440878
nsv518708 CNV loss 19592680
nsv519680 CNV loss 19592680
nsv522009 CNV gain 19592680
nsv585276 CNV gain 21841781
nsv833895 CNV loss 17160897
nsv833896 CNV loss 17160897
nsv833897 CNV loss 17160897
nsv956217 CNV deletion 24416366

Variation tolerance for PTPRA Gene

Residual Variation Intolerance Score: 6.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRA Gene

Disorders for PTPRA Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTPRA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
estrogen-receptor negative breast cancer
- elite association - COSMIC cancer census association via MalaCards
Search PTPRA in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPRA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PTPRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRA Gene

Publications for PTPRA Gene

  1. Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase. (PMID: 2172030) Jirik F.R. … Harder K.W. (FEBS Lett. 1990) 2 3 4 22 64
  2. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. (PMID: 2169617) Kaplan R. … Schlessinger J. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 64
  3. Sequence of a cDNA encoding human LRP (leukocyte common antigen- related peptide). (PMID: 2175890) Ohagi S. … Steiner D.F. (Nucleic Acids Res. 1990) 3 4 22 64
  4. Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility. (PMID: 20208566) Krndija D. … von Wichert G. (Oncogene 2010) 3 22 64
  5. Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling. (PMID: 19497848) Wang Q. … McCulloch C.A. (J. Biol. Chem. 2009) 3 22 64

Products for PTPRA Gene

Sources for PTPRA Gene

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