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Aliases for PTPRA Gene

Aliases for PTPRA Gene

  • Protein Tyrosine Phosphatase, Receptor Type, A 2 3
  • Protein-Tyrosine Phosphatase Alpha 3 4
  • R-PTP-Alpha 3 4
  • EC 3.1.3.48 4 63
  • PTPRL2 3 4
  • PTPA 3 4
  • Leukocyte Common Antigen-Related Peptide (Protein Tyrosine Phosphate) 3
  • Protein Tyrosine Phosphatase, Receptor Type, Alpha Polypeptide 3
  • PTPLCA-Related Phosphatase 3
  • Tyrosine Phosphatase Alpha 3
  • PTPase-Alpha 3
  • HPTPalpha 3
  • HEPTP 3
  • HPTPA 3
  • RPTPA 3
  • HLPR 3
  • LRP 3

External Ids for PTPRA Gene

Previous HGNC Symbols for PTPRA Gene

  • PTPRL2
  • PTPA

Previous GeneCards Identifiers for PTPRA Gene

  • GC20P002809
  • GC20P002816
  • GC20P002770
  • GC20P002771
  • GC20P002772
  • GC20P002793
  • GC20P002794
  • GC20P002795
  • GC20P002796
  • GC20P002797

Summaries for PTPRA Gene

Entrez Gene Summary for PTPRA Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRA Gene

PTPRA (Protein Tyrosine Phosphatase, Receptor Type, A) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRT.

Gene Wiki entry for PTPRA Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRA Gene

Genomics for PTPRA Gene

Regulatory Elements for PTPRA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPRA Gene

Chromosome:
20
Start:
2,864,184 bp from pter
End:
3,039,076 bp from pter
Size:
174,893 bases
Orientation:
Plus strand

Genomic View for PTPRA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRA Gene

Proteins for PTPRA Gene

  • Protein details for PTPRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18433-PTPRA_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase alpha
    Protein Accession:
    P18433
    Secondary Accessions:
    • A8K2G8
    • D3DVX5
    • Q14513
    • Q7Z2I2
    • Q96TD9

    Protein attributes for PTPRA Gene

    Size:
    802 amino acids
    Molecular mass:
    90600 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PTPRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRA Gene

Proteomics data for PTPRA Gene at MOPED

Post-translational modifications for PTPRA Gene

  • Glycosylation at Asn 21, Asn 36, Asn 68, Asn 80, Asn 86, Asn 104, and Asn 124
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTPRA (PTPRA)

Domains & Families for PTPRA Gene

Gene Families for PTPRA Gene

Graphical View of Domain Structure for InterPro Entry

P18433

UniProtKB/Swiss-Prot:

PTPRA_HUMAN :
  • Contains 2 tyrosine-protein phosphatase domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
Domain:
  • Contains 2 tyrosine-protein phosphatase domains.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
genes like me logo Genes that share domains with PTPRA: view

Function for PTPRA Gene

Molecular function for PTPRA Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type IV,alpha polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

Enzyme Numbers (IUBMB) for PTPRA Gene

Gene Ontology (GO) - Molecular Function for PTPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity TAS 10748206
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 2169617
GO:0005515 protein binding IPI 7518772
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPRA: view
genes like me logo Genes that share phenotypes with PTPRA: view

Animal Models for PTPRA Gene

MGI Knock Outs for PTPRA:

Animal Model Products

miRNA for PTPRA Gene

miRTarBase miRNAs that target PTPRA

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRA

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PTPRA Gene

Localization for PTPRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRA Gene COMPARTMENTS Subcellular localization image for PTPRA gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 2
golgi apparatus 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PTPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2169617
GO:0043235 receptor complex IDA 23382219
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with PTPRA: view

Pathways & Interactions for PTPRA Gene

SuperPathways for PTPRA Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Activation of cAMP-Dependent PKA
3 Immune System
4 Signaling by GPCR
5 Developmental Biology
genes like me logo Genes that share pathways with PTPRA: view

Pathways by source for PTPRA Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for PTPRA Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PTPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0006468 protein phosphorylation --
GO:0006470 protein dephosphorylation --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PTPRA: view

Drugs & Compounds for PTPRA Gene

(5) Drugs for PTPRA Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Potassium Experimental Pharma 0
Calcium Nutra 0
cysteine Nutra 143
serine Nutra 420
tyrosine Nutra 547

(8) Additional Compounds for PTPRA Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
glucose
H2O2
genes like me logo Genes that share compounds with PTPRA: view

Transcripts for PTPRA Gene

Unigene Clusters for PTPRA Gene

Protein tyrosine phosphatase, receptor type, A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42a · 42b ^ 43a ·
SP1:
SP2:
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: - -
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

ExUns: 43b ^ 44 ^ 45
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PTPRA Gene

GeneLoc Exon Structure for
PTPRA
ECgene alternative splicing isoforms for
PTPRA

Expression for PTPRA Gene

mRNA expression in normal human tissues for PTPRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPRA Gene

This gene is overexpressed in Breast (23.9), Peripheral blood mononuclear cells (8.2), and Heart (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRA Gene



SOURCE GeneReport for Unigene cluster for PTPRA Gene Hs.269577

genes like me logo Genes that share expression patterns with PTPRA: view

Protein tissue co-expression partners for PTPRA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTPRA Gene

Orthologs for PTPRA Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRA 35
  • 93.01 (n)
  • 96.13 (a)
PTPRA 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRA 35
  • 93.77 (n)
  • 96.13 (a)
PTPRA 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpra 35
  • 90.67 (n)
  • 95.84 (a)
Ptpra 16
Ptpra 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPRA 35
  • 99.58 (n)
  • 99.63 (a)
PTPRA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpra 35
  • 91.05 (n)
  • 95.59 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPRA 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRA 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRA 35
  • 78.26 (n)
  • 87.99 (a)
PTPA 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpra 35
  • 74.4 (n)
  • 84.32 (a)
African clawed frog
(Xenopus laevis)
Amphibia ptpa-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii ptpra 35
  • 71.86 (n)
  • 78.99 (a)
ptpra 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7180 37
  • 29 (a)
Ptp52F 37
  • 37 (a)
Ptp69D 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea F20H11.4 37
  • 30 (a)
M04G7.2 37
  • 37 (a)
T22C1.8 37
  • 36 (a)
ZK616.7 37
  • 37 (a)
ptp-3 36
  • 13 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4172 35
Species with no ortholog for PTPRA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRA Gene

ENSEMBL:
Gene Tree for PTPRA (if available)
TreeFam:
Gene Tree for PTPRA (if available)

Paralogs for PTPRA Gene

Paralogs for PTPRA Gene

Pseudogenes.org Pseudogenes for PTPRA Gene

genes like me logo Genes that share paralogs with PTPRA: view

Variants for PTPRA Gene

Sequence variations from dbSNP and Humsavar for PTPRA Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs4047 -- 2,907,167(-) gaaca(A/G)cactt intron-variant
rs148078 -- 2,880,957(+) gagcc(A/G)tgatt intron-variant
rs490535 -- 3,020,697(+) GTTAC(C/T)GTGTT intron-variant
rs568235 -- 3,024,767(+) ACTCT(A/G)GTAAC intron-variant
rs568513 -- 3,036,258(+) CCCAG(C/G)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRA Gene

Variant ID Type Subtype PubMed ID
nsv833895 CNV Loss 17160897
nsv522009 CNV Gain 19592680
nsv518708 CNV Loss 19592680
esv2722110 CNV Deletion 23290073
esv2207372 CNV Deletion 18987734
esv2722111 CNV Deletion 23290073
esv2722112 CNV Deletion 23290073
nsv3262 CNV Insertion 18451855
nsv519680 CNV Loss 19592680
esv2272134 CNV Deletion 18987734
esv2722113 CNV Deletion 23290073
nsv179703 CNV Loss 16902084
esv5581 CNV Loss 19470904
nsv912603 CNV Gain 21882294
esv2369681 CNV Deletion 18987734
nsv833896 CNV Loss 17160897
esv2664542 CNV Deletion 23128226
esv2669632 CNV Deletion 23128226
nsv3263 CNV Insertion 18451855
nsv180455 CNV Loss 16902084
esv2722114 CNV Deletion 23290073
nsv833897 CNV Loss 17160897
nsv180708 CNV Loss 16902084
esv2661520 CNV Deletion 23128226
esv994080 CNV Gain 20482838

Variation tolerance for PTPRA Gene

Residual Variation Intolerance Score: 6.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRA Gene

HapMap Linkage Disequilibrium report
PTPRA
Human Gene Mutation Database (HGMD)
PTPRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRA Gene

Disorders for PTPRA Gene

Relevant External Links for PTPRA

Genetic Association Database (GAD)
PTPRA
Human Genome Epidemiology (HuGE) Navigator
PTPRA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRA
genes like me logo Genes that share disorders with PTPRA: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPRA Gene

Publications for PTPRA Gene

  1. Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase. (PMID: 2172030) Jirik F.R. … Harder K.W. (FEBS Lett. 1990) 2 23 67
  2. Catalytically active membrane-distal phosphatase domain of receptor protein-tyrosine phosphatase alpha is required for Src activation. (PMID: 20158519) Vacaru A.M. … den Hertog J. (FEBS J. 2010) 23 67
  3. Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility. (PMID: 20208566) Krndija D. … von Wichert G. (Oncogene 2010) 23 67
  4. Serine dephosphorylation of receptor protein tyrosine phosphatase alpha in mitosis induces Src binding and activation. (PMID: 20385765) Vacaru A.M. … den Hertog J. (Mol. Cell. Biol. 2010) 23 67
  5. Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA. (PMID: 20046046) Isomoto H. … Hirayama T. (Tohoku J. Exp. Med. 2010) 23 67

Products for PTPRA Gene

Sources for PTPRA Gene

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