PTPN9 Gene
protein-coding GIFtS: 60
GCID: GC15M075759
|
|
protein tyrosine phosphatase, non-receptor type 9
| |
Aliases
for PTPN9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Tyrosine Phosphatase, Non-Receptor Type 91 2 | | EC 3.1.3.483 8 | | MEG21 2 | | PTPMEG22 | | Protein-Tyrosine Phosphatase MEG22 3 | | PTPase-MEG22 | | PTPase MEG22 3 | | Tyrosine-Protein Phosphatase Non-Receptor Type 92 |
Export aliases for PTPN9 gene to outside databasesPrevious GC identifers: GC15M071637 GC15M068850 GC15M073335 GC15M073475 GC15M073546 GC15M052517 |
Summaries
for PTPN9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PTPN9:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitoticcycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity withyeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretionthrough the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to beinvolved in signaling events regulating phagocytosis. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378Function: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions ofthe Golgi apparatus
Gene Wiki entry for PTPN9
|
Genomic Views
for PTPN9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PTPN9 gene promoter:
AhR RP58 Spz1 NF-1 NF-1/L Pax-5 p53 Arnt AREB6 MZF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PTPN9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q24.2 Ensembl cytogenetic band: 15q24.2 HGNC cytogenetic band: 15q23PTPN9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M075759: view genomic region
(about GC identifiers)
Start:
|
75,759,462 bp from pter |
End:
|
75,871,630 bp from pter |
Size:
|
112,169 bases |
Orientation:
|
minus strand |
|
Proteins
for PTPN9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378 (See
protein sequence)Recommended Name: Tyrosine-protein phosphatase non-receptor type 9 Size: 593 amino acids; 68020 Da
Subcellular location: Cytoplasm (Probable)
4 PDB 3D structures from  and Proteopedia  for PTPN9:2PA5 (3D)
4GE2 (3D)
4GE5 (3D)
4GE6 (3D)
Secondary accessions: Q53XR9Explore the universe of human proteins at neXtProt for PTPN9: NX_P43378
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P43378
4/5 DME Specific Peptides for PTPN9 (P43378) (see all 5)
PTPN9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002824.1
ENSEMBL proteins: ENSP00000303554 ENSP00000455934
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
PTPN9 for ontologies About GeneDecksing
PTPN9 Antibody Products:
Assay Products for PTPN9: |
Protein
Domains /
Families
for PTPN9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PTPN9 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P43378ProtoNet protein and cluster: P43378 4 Blocks protein families: IPB000242 Protein tyrosine phosphatase signature IPB001071 Cellular retinaldehyde-binding protein signature IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) IPB008273 Cellular retinaldehyde-binding/triple function
UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamilySimilarity: Contains 1 CRAL-TRIO domainSimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function
for PTPN9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378Function: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions ofthe Golgi apparatusCatalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateEnzyme Number (IUBMB): EC 3.1.3.481 2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN9 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN9 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
PTPN9 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for PTPN9:
Animal Models:
Mouse knock-out Ptpn9tm1Dny for PTPN9
12 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ptpn9):
PTPN9 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PTPN9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PAK Pathway | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPN9
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN9
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/11 Interacting proteins for PTPN9 (P433781, 2, 3 ENSP000003035544) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
PTPN9 for ontologies About GeneDecksing
|
Drugs & Compounds
for PTPN9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PTPN9 for compounds About GeneDecksing
 Browse Tocris compounds for PTPN9
2 HMDB Compounds for PTPN9 About this table
3 Novoseek chemical compound relationships for PTPN9 gene About this table
Search CenterWatch for drugs/clinical trials and news about PTPN9 / PTN9
|
Transcripts
for PTPN9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PTPN9 gene: NM_002833.2 Unigene Cluster for PTPN9: Protein tyrosine phosphatase, non-receptor type 9 Hs.445775 [show with all ESTs]Unigene Representative Sequence: NM_0028335 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000306726(uc002bal.3) ENST00000568108 ENST00000563835 ENST00000564970
ENST00000561731
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN9 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PTPN9 (NM_002833) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTPN9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN9 |
Additional cDNA sequence: AK126088.1 AL360201.1 BC010863.1 BC071574.1 BT007405.1 M83738.1 16 DOTS entries: DT.100785572 DT.416479 DT.99932496 DT.95275990 DT.99973228 DT.100736878 DT.91995223 DT.121052866 DT.121052917 DT.207119 DT.92428239 DT.75125478 DT.121052819 DT.92428236 DT.95305002 DT.100698153 24/188 AceView cDNA sequences (see all 188): AW138799 W67862 BU608741 AW665389 AI784154 BM967315 H97696 BQ024301 BT007405 AI991947 AW006166 BM982093 AI950192 AW183876 AW303445 AW138163 AA625595 M83738 BC010863 BE220540 CB528499 AA651877 AW572418 AI591045
GeneLoc Exon Structure
|
Expression
for PTPN9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PTPN9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PTPN9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTPN9
SOURCE GeneReport for Unigene cluster: Hs.445775
SABiosciences Expression via Pathway-Focused PCR Array including PTPN9:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN9
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN9 |
Orthologs
for PTPN9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PTPN9 gene from 7/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PTPN91 |
protein tyrosine phosphatase, non-receptor type 9 |
72.93(n)
77.22(a) |
|
415308 XM_413696.3 XP_413696.3 |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC525842 |
similar to protein tyrosine phosphatase, non-receptor more |
74.69(n) |
|
BC043621.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ptpn9a1 |
protein tyrosine phosphatase, non-receptor type 9, more |
67.43(n)
69.88(a) |
|
100526653 XM_003201394.1 XP_003201442.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
l(1)G02326 |
lethal (1) G0232 |
24(a) |
1 ↔ 1 |
X(9520367-9553178) |
worm
(Caenorhabditis elegans) |
Secernentea |
M04G7.23 |
protein-tyrosine phosphatase |
34(a)
(best of 11) |
|
IV(457794-458967) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATPTP16 |
tyrosine phosphatase 1 |
26(a) |
1 → many |
1(27026711-27029092) |
rice
(Oryza sativa) |
Liliopsida |
---- |
Protein-tyrosine phosphatase domain containing pro...Protein-tyrosine phosphatase domain containing pro... |
27(a)22(a) |
many ↔ manymany ↔ many |
12(3791109-3796496) 11(4000708-4008336) |
ENSEMBL Gene Tree for PTPN9 (if available)
TreeFam Gene Tree for PTPN9 (if available) |
Paralogs
for PTPN9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PTPN9 gene
- PTPN12 PTPN32 PTPN20C2 FRMPD22 PTPN42 PTPN132 PTPN142 PTPN20B2
- PTPN212 PTPN22 PTPN20A2
11 SIMAP similar genes for PTPN9 using alignment to 3 protein entries: PTN9_HUMAN (see all proteins):DKFZp781C1038 DKFZp313F1310 PTPN5 PTPRR BPTP-2 PTPN1
DKFZp566K0524 PTPN2 PTPN7 PTPRS BPTP-3
PTPN9 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PTPN9
PGOHUM00000262227
|
Genomic Variants
for PTPN9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PTPN9 (75759462 - 75871630 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PTPN9
2 CNVs: 58736 102137
1 Indel: 25562 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPN9 |
|
Disorders
/ Diseases
for PTPN9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PTPN9 for disorders About GeneDecksing
OMIM gene information: 600768
OMIM disorders: --
4  diseases for PTPN9: About MalaCardspolycythemia vera polycythemia breast cancer hepatitis
Export disorders for PTPN9 gene to outside databases
|
Publications
for PTPN9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PTPN9 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with PTPN9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and expression of a cytosolic megakaryocyte protein-tyrosine- phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p. (PubMed id 1557404)1, 2, 3, 9 Gu M.... Majerus P.W. (1992)
- Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)1, 2 Barr A.J.... Knapp S. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides. (PubMed id 11711529)1, 9 Kruger J.M....Downey G.P. (2002)
- Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. (PubMed id 14662869)1, 9 Huynh H....Mustelin T. (2003)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Tyrosine phosphatase PTP-MEG2 negatively regulates vas cular endothelial growth factor receptor signaling and function in endothelial c ells. (PubMed id 22763125)1 Hao Q....Tang H. (2012)
- Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A genome-wide association study in 19 633 Japanese su bjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1 Okada Y....Kamatani N. (2010)
|
External Searches for PTPN9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PTPN9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PTPN9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PTPN9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PTPN9 gene:
Search GeneIP for patents involving PTPN9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PTPN9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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