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Aliases for PTPN9 Gene

Aliases for PTPN9 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 9 2 3 5
  • Protein-Tyrosine Phosphatase MEG2 3 4
  • PTPase MEG2 3 4
  • EC 4 63
  • PTPase-MEG2 3
  • PTPMEG2 3
  • MEG2 3

External Ids for PTPN9 Gene

Previous GeneCards Identifiers for PTPN9 Gene

  • GC15M071637
  • GC15M068850
  • GC15M073335
  • GC15M073475
  • GC15M073546
  • GC15M075759
  • GC15M052517

Summaries for PTPN9 Gene

Entrez Gene Summary for PTPN9 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPN9 Gene

PTPN9 (Protein Tyrosine Phosphatase, Non-Receptor Type 9) is a Protein Coding gene. Among its related pathways are PAK Pathway. GO annotations related to this gene include phosphatase activity and non-membrane spanning protein tyrosine phosphatase activity. An important paralog of this gene is PTPRO.

UniProtKB/Swiss-Prot for PTPN9 Gene

  • Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.

Gene Wiki entry for PTPN9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN9 Gene

Genomics for PTPN9 Gene

Regulatory Elements for PTPN9 Gene

Enhancers for PTPN9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTPN9 on UCSC Golden Path with GeneCards custom track

Promoters for PTPN9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTPN9 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPN9 Gene

75,463,251 bp from pter
75,579,291 bp from pter
116,041 bases
Minus strand

Genomic View for PTPN9 Gene

Genes around PTPN9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN9 Gene

Proteins for PTPN9 Gene

  • Protein details for PTPN9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 9
    Protein Accession:
    Secondary Accessions:
    • Q53XR9

    Protein attributes for PTPN9 Gene

    593 amino acids
    Molecular mass:
    68020 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPN9 Gene

neXtProt entry for PTPN9 Gene

Proteomics data for PTPN9 Gene at MOPED

Selected DME Specific Peptides for PTPN9 Gene

Post-translational modifications for PTPN9 Gene

  • Ubiquitination at Lys 185
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPN9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PTPN9 Gene

Gene Families for PTPN9 Gene

Suggested Antigen Peptide Sequences for PTPN9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRAL-TRIO domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily.
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily.
genes like me logo Genes that share domains with PTPN9: view

Function for PTPN9 Gene

Molecular function for PTPN9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.

Enzyme Numbers (IUBMB) for PTPN9 Gene

Gene Ontology (GO) - Molecular Function for PTPN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IDA 19167335
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS 1557404
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTPN9: view
genes like me logo Genes that share phenotypes with PTPN9: view

Animal Models for PTPN9 Gene

MGI Knock Outs for PTPN9:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPN9 Gene

Localization for PTPN9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN9 Gene


Subcellular locations from

Jensen Localization Image for PTPN9 Gene COMPARTMENTS Subcellular localization image for PTPN9 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PTPN9 Gene

Pathways & Interactions for PTPN9 Gene

SuperPathways for PTPN9 Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPN9: view

Pathways by source for PTPN9 Gene

1 Qiagen pathway for PTPN9 Gene

SIGNOR curated interactions for PTPN9 Gene


Gene Ontology (GO) - Biological Process for PTPN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,TAS 1557404
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with PTPN9: view

Drugs & Compounds for PTPN9 Gene

(1) Drugs for PTPN9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for PTPN9 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with PTPN9: view

Transcripts for PTPN9 Gene

Unigene Clusters for PTPN9 Gene

Protein tyrosine phosphatase, non-receptor type 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN9 Gene

No ASD Table

Relevant External Links for PTPN9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPN9 Gene

mRNA expression in normal human tissues for PTPN9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPN9 Gene

This gene is overexpressed in Breast (7.4) and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN9 Gene

SOURCE GeneReport for Unigene cluster for PTPN9 Gene Hs.445775

genes like me logo Genes that share expression patterns with PTPN9: view

Protein tissue co-expression partners for PTPN9 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTPN9 Gene

Orthologs for PTPN9 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PTPN9 35
  • 92.47 (n)
  • 96.12 (a)
PTPN9 36
  • 91 (a)
(Canis familiaris)
Mammalia PTPN9 35
  • 93.72 (n)
  • 96.51 (a)
PTPN9 36
  • 97 (a)
(Mus musculus)
Mammalia Ptpn9 35
  • 91.62 (n)
  • 97.3 (a)
Ptpn9 16
Ptpn9 36
  • 97 (a)
(Pan troglodytes)
Mammalia PTPN9 35
  • 95.16 (n)
  • 94.3 (a)
PTPN9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ptpn9 35
  • 91.91 (n)
  • 97.13 (a)
(Monodelphis domestica)
Mammalia PTPN9 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia PTPN9 36
  • 77 (a)
(Gallus gallus)
Aves PTPN9 35
  • 72.92 (n)
  • 77.08 (a)
PTPN9 36
  • 75 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52584 35
(Danio rerio)
Actinopterygii ptpn9a 35
  • 67.43 (n)
  • 69.88 (a)
ptpn9a 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001109 35
  • 52.55 (n)
  • 48.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0232 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea C02B10.6 37
  • 33 (a)
C17H12.3 37
  • 32 (a)
F25H5.7 37
  • 33 (a)
F36H1.3 37
  • 32 (a)
F36H12.10 37
  • 33 (a)
F47B3.1 37
  • 32 (a)
F47B3.6 37
  • 32 (a)
F55F8.7 37
  • 33 (a)
K07F5.8 37
  • 31 (a)
M04G7.2 37
  • 34 (a)
ZK616.7 37
  • 33 (a)
Species with no ortholog for PTPN9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPN9 Gene

Gene Tree for PTPN9 (if available)
Gene Tree for PTPN9 (if available)

Paralogs for PTPN9 Gene

(10) SIMAP similar genes for PTPN9 Gene using alignment to 3 proteins: Pseudogenes for PTPN9 Gene

genes like me logo Genes that share paralogs with PTPN9: view

Variants for PTPN9 Gene

Sequence variations from dbSNP and Humsavar for PTPN9 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs5813803 -- 75,559,785(+) AAAAA(-/AA)GAAGA intron-variant
rs6495181 -- 75,521,824(+) GTTCA(C/T)GATAC intron-variant
rs6495182 -- 75,522,047(+) GATGT(C/T)GAGAG intron-variant
rs12324230 -- 75,514,570(+) aagac(C/T)tggtc intron-variant
rs12324246 -- 75,514,835(+) cgcaa(A/G)ctata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPN9 Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV Deletion 23290073
nsv904387 CNV Gain 21882294
esv2749895 CNV Deletion 23290073
dgv2414n71 CNV Loss 21882294
nsv827390 CNV Gain 20364138
esv1633101 CNV Deletion 17803354
esv1611493 CNV Insertion 17803354
esv1056937 CNV Insertion 17803354
esv1664478 CNV Insertion 17803354
nsv904390 CNV Loss 21882294
nsv819520 CNV Loss 19587683
esv2480100 CNV Deletion 19546169
esv2749897 CNV Deletion 23290073
esv1178689 CNV Deletion 17803354
esv2675670 CNV Deletion 23128226

Variation tolerance for PTPN9 Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PTPN9 Gene

Disorders for PTPN9 Gene

Relevant External Links for PTPN9

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PTPN9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPN9 Gene

Publications for PTPN9 Gene

  1. Cloning and expression of a cytosolic megakaryocyte protein-tyrosine- phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p. (PMID: 1557404) Gu M. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23 67
  2. Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. (PMID: 14662869) Huynh H. … Mustelin T. (J. Immunol. 2003) 3 23
  3. Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides. (PMID: 11711529) Kruger J.M. … Downey G.P. (J. Biol. Chem. 2002) 3 23
  4. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for PTPN9 Gene

Sources for PTPN9 Gene