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PTPN9 Gene

protein-coding   GIFtS: 63
GCID: GC15M075759

Protein Tyrosine Phosphatase, Non-Receptor Type 9

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 91 2     MEG22
Protein-Tyrosine Phosphatase MEG22 3     PTPMEG22
PTPase MEG22 3     PTPase-MEG22
EC 3.1.3.483 8     Tyrosine-Protein Phosphatase Non-Receptor Type 92

External Ids:    HGNC: 96611   Entrez Gene: 57802   Ensembl: ENSG000001694107   OMIM: 6007685   UniProtKB: P433783   

Export aliases for PTPN9 gene to outside databases

Previous GC identifers: GC15M071637 GC15M068850 GC15M073335 GC15M073475 GC15M073546 GC15M052517


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPN9 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant
similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required
for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by
polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PTPN9 Gene:
PTPN9 (protein tyrosine phosphatase, non-receptor type 9) is a protein-coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity and non-membrane spanning protein tyrosine phosphatase activity. An important paralog of this gene is PTPN1.

UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378
Function: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in
functions of the Golgi apparatus

Gene Wiki entry for PTPN9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPN9 gene promoter:
         AhR   RP58   Spz1   NF-1   NF-1/L   Pax-5   p53   Arnt   AREB6   MZF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN9 promoter sequence
   Search Chromatin IP Primers for PTPN9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q23

PTPN9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN9 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075759:  view genomic region     (about GC identifiers)

Start:
75,759,462 bp from pter      End:
75,871,630 bp from pter
Size:
112,169 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 9  
Size: 593 amino acids; 68020 Da
5 PDB 3D structures from and Proteopedia for PTPN9:
2PA5 (3D)        4GE2 (3D)        4GE5 (3D)        4GE6 (3D)        4ICZ (3D)    
Secondary accessions: Q53XR9

Explore the universe of human proteins at neXtProt for PTPN9: NX_P43378

Explore proteomics data for PTPN9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys185
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTPN9 (P43378) (see all 5)
     DQTRVKL  VVHCSAG  PIVVHCS  DYINASF 


    See PTPN9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002824.1  
    ENSEMBL proteins: 
     ENSP00000303554   ENSP00000455934  

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    antibodies-online proteins for PTPN9 (6 products) 

     
    antibodies-online peptides for PTPN9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    5 InterPro protein domains:
     IPR001251 CRAL-TRIO_dom
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase
     IPR011074 CRAL/TRIO_N_dom

    Graphical View of Domain Structure for InterPro Entry P43378

    ProtoNet protein and cluster: P43378

    4 Blocks protein domains:
    IPB000242 Protein tyrosine phosphatase signature
    IPB001071 Cellular retinaldehyde-binding protein signature
    IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
    IPB008273 Cellular retinaldehyde-binding/triple function


    UniProtKB/Swiss-Prot: PTN9_HUMAN, P43378
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily
    Similarity: Contains 1 CRAL-TRIO domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPN9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN9_HUMAN, P43378
    Function: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in
    functions of the Golgi apparatus
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IDA19167335
    GO:0004726non-membrane spanning protein tyrosine phosphatase activity TAS1557404
    GO:0005515protein binding IPI12907755
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with PTPN9           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PTPN9:
     Decreased focal adhesion (FA)   Increased apoptosis  Increased cell death HMECs cel  Increased cell death in breast 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ptpn9):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     nervous system  skeleton 

    Find genes that share phenotypes with PTPN9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ptpn9tm1Dny for PTPN9

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTPN9
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    miRNA
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    miRTarBase miRNAs that target PTPN9:
    hsa-mir-183-5p (MIRT047068), hsa-mir-93-3p (MIRT038760), hsa-mir-769-5p (MIRT016099), hsa-mir-186-5p (MIRT021174), hsa-mir-24-3p (MIRT035526), hsa-mir-320a (MIRT044505), hsa-mir-100-5p (MIRT048461), hsa-mir-124-3p (MIRT023053)

    Block miRNA regulation of human, mouse, rat PTPN9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPN9 (see all 50):
    hsa-miR-411* hsa-miR-126 hsa-miR-328 hsa-miR-379* hsa-miR-128 hsa-miR-1276 hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidPTPN9 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTN9_HUMAN, P43378: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10940933

    Find genes that share ontologies with PTPN9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPN9 About    
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPN9
        Epithelial Adherens Junctions



        Pathway & Disease-focused RT2 Profiler PCR Array including PTPN9: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPN9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTPN9 (P433781, 2, 3 ENSP000003035544) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NSFP464591, 2, 3, ENSP000003812934EBI-742898,EBI-712251 MINT-8217359 MINT-8217371 I2D: score=5 STRING: ENSP00000381293
    GHRP109121, 2, 3, ENSP000002308824EBI-742898,EBI-286316 MINT-6797548 MINT-6797775 I2D: score=3 STRING: ENSP00000230882
    STX6O437523, ENSP000002583014I2D: score=3 STRING: ENSP00000258301
    RTN3O951973, ENSP000003441064I2D: score=4 STRING: ENSP00000344106
    GAB1Q134803, ENSP000002629954I2D: score=1 STRING: ENSP00000262995
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS1557404
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS1557404

    Find genes that share ontologies with PTPN9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPN9 (PTN9)

    2 HMDB Compounds for PTPN9    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 Novoseek inferred chemical compound relationships for PTPN9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinaldehyde 82.1 1 15299870 (1)
    phosphatidylinositol 58.3 4 11711529 (1)
    tyrosine 48.3 8 11711529 (3), 1557404 (2), 14662869 (1), 19347325 (1) (see all 5)



    Find genes that share compounds with PTPN9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTPN9 gene: 
    NM_002833.3  

    Unigene Cluster for PTPN9:

    Protein tyrosine phosphatase, non-receptor type 9
    Hs.445775  [show with all ESTs]
    Unigene Representative Sequence: NM_002833
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306726(uc002bal.3) ENST00000568108 ENST00000563835 ENST00000564970
    ENST00000561731
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PTPN9 (see all 50):
    hsa-miR-411* hsa-miR-126 hsa-miR-328 hsa-miR-379* hsa-miR-128 hsa-miR-1276 hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidPTPN9 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PTPN9
      QuantiFast Probe-based Assays in human, mouse, rat PTPN9

    Additional mRNA sequence: 

    AK126088.1 AL360201.1 BC010863.1 BC071574.1 BT007405.1 M83738.1 

    21 DOTS entries:

    DT.100785572  DT.416479  DT.99932496  DT.95275990  DT.99973228  DT.100736878  DT.91995223  DT.121052866 
    DT.121052917  DT.207119  DT.92428239  DT.75125478  DT.100698153  DT.121052819  DT.92428236  DT.95305002 
    DT.100723295  DT.100819631  DT.121052922  DT.75185804  DT.91739539 

    Selected AceView cDNA sequences (see all 188):

    AW468879 BT007405 AI218727 AW138799 BM801195 BM982093 AI202869 BQ024301 
    BM727905 AI885845 AW072956 AI332539 AI168232 BF222928 NM_002833 BU154770 
    BM803033 AI243423 AI367760 AI591045 AW300748 AI632814 AI989610 AI253052 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPN9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTPN9 Expression
    About this image


    PTPN9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
    PTPN9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPN9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445775
        Pathway & Disease-focused RT2 Profiler PCR Array including PTPN9: 
              Protein Phosphatases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTPN9 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn91 , 5 protein tyrosine phosphatase, non-receptor type 91, 5 91.62(n)1
    97.3(a)1
      9 (30.70 cM)5
    562941  NM_019651.21  NP_062625.21 
     569949685 
    chicken
    (Gallus gallus)
    Aves PTPN91 protein tyrosine phosphatase, non-receptor type 9 72.92(n)
    77.08(a)
      415308  XM_413696.4  XP_413696.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525842 similar to protein tyrosine phosphatase, non-receptor more 74.69(n)    BC043621.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ptpn9a1 protein tyrosine phosphatase, non-receptor type 9, more 67.43(n)
    69.88(a)
      100526653  XM_003201394.2  XP_003201442.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(1)G02326
    lethal (1) G0232
    33(a)
    1 ↔ 1
    X(9520367-9553178)


    ENSEMBL Gene Tree for PTPN9 (if available)
    TreeFam Gene Tree for PTPN9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPN9 gene
    PTPN12  PTPN222  PTPN112  PTPN62  PTPRN22  PTPRN2  PTPN142  PTPN212  
    PTPN20B2  PTPN22  PTPN182  PTPN122  PTPN20A2  
    10 SIMAP similar genes for PTPN9 using alignment to 3 protein entries:     PTN9_HUMAN (see all proteins):
    DKFZp781C1038    DKFZp313F1310    PTPN5    PTPRR    BPTP-2    PTPN1
    DKFZp566K0524    PTN2    PTPN7    PTPRS

    Find genes that share paralogs with PTPN9           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PTPN9
    PGOHUM00000262227


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPN9 (see all 1788)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs611352771,2
    C,F--55810572(+) TTTAAG/AAACTT 1 -- ds50012Minor allele frequency- A:0.05WA 120
    rs1474657401,2
    --55810678(+) GACCAA/GCTTGA 1 -- ds50010--------
    rs1485279741,2
    C--55810715(+) CCCTCC/TGGACC 1 -- ds50010--------
    rs1851542891,2
    --55810795(+) TGAATC/TGTTGT 1 -- ds50010--------
    rs1170034511,2
    C,F--55810796(+) GAATTG/ATTGTG 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs1898130021,2
    --55810940(+) GAACTC/GAAAGT 1 -- ds50010--------
    rs1172339321,2
    C,F--55810992(+) CCCTCC/TCAGAC 1 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1832127641,2
    --55811068(+) CATGTC/TGGTAT 1 -- ut310--------
    rs772024021,2
    C,F--55811157(+) GTCCAT/CTGATA 1 -- ut311Minor allele frequency- C:0.08EA 120
    rs1879523051,2
    --55811183(+) AATGAC/TTGTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PTPN9 (75759462 - 75871630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTPN9 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749897CNV Deletion23290073
    esv2480100CNV Deletion19546169
    esv1178689CNV Deletion17803354
    esv2749895CNV Deletion23290073
    esv2675670CNV Deletion23128226
    esv2749894CNV Deletion23290073
    esv1633101CNV Deletion17803354
    esv1611493CNV Insertion17803354
    esv1664478CNV Insertion17803354
    esv1056937CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600768    OMIM disorders: --


    Find genes that share disorders with PTPN9           About GenesLikeMe

    Genetic Association Database (GAD): PTPN9

    Export disorders for PTPN9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPN9 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with PTPN9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a cytosolic megakaryocyte protein-tyrosine- phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p. (PubMed id 1557404)1, 2, 3, 9 Gu M.... Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1, 4 Okada Y....Kamatani N. (Hum. Mol. Genet. 2010)
    3. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)1, 2 Barr A.J.... Knapp S. (Cell 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides. (PubMed id 11711529)1, 9 Kruger J.M....Downey G.P. (J. Biol. Chem. 2002)
    6. Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. (PubMed id 14662869)1, 9 Huynh H....Mustelin T. (J. Immunol. 2003)
    7. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells. (PubMed id 22763125)1 Hao Q....Tang H. (Am. J. Physiol., Cell Physiol. 2012)
    10. Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer. (PubMed id 22394684)1 Su F....Chang Z. (Breast Cancer Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5780 HGNC: 9661 AceView: PTPN9 Ensembl:ENSG00000169410 euGenes: HUgn5780
    ECgene: PTPN9 H-InvDB: PTPN9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PTPN9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPN9 gene:
    Search GeneIP for patents involving PTPN9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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