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Aliases for PTPN7 Gene

Aliases for PTPN7 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 7 2 3 5
  • Hematopoietic Protein-Tyrosine Phosphatase 3 4
  • Protein-Tyrosine Phosphatase LC-PTP 3 4
  • EC 3.1.3.48 4 61
  • HEPTP 3 4
  • Protein-Tyrosine Phosphatase, Nonreceptor-Type, Stress Induced 3
  • Tyrosine-Protein Phosphatase Non-Receptor Type 7 3
  • Dual Specificity Phosphatase 1 3
  • BPTP-4 3
  • LC-PTP 3
  • PTPNI 3
  • LPTP 3

External Ids for PTPN7 Gene

Previous GeneCards Identifiers for PTPN7 Gene

  • GC01M199800
  • GC01M197550
  • GC01M198582
  • GC01M199404
  • GC01M198847
  • GC01M200382
  • GC01M202116
  • GC01M173282

Summaries for PTPN7 Gene

Entrez Gene Summary for PTPN7 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for PTPN7 Gene

PTPN7 (Protein Tyrosine Phosphatase, Non-Receptor Type 7) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Downstream signaling in naive CD8+ T cells. GO annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRR.

UniProtKB/Swiss-Prot for PTPN7 Gene

  • Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.

Gene Wiki entry for PTPN7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN7 Gene

Genomics for PTPN7 Gene

Regulatory Elements for PTPN7 Gene

Enhancers for PTPN7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G202157 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.6 -0.5 -521 8.9 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 SIN3A YBX1 ZBTB7B YY1 PTPN7 RNPEP CYB5R1 PTPRVP ENSG00000273478 RPS27P8
GH01G201999 1.1 ENCODE dbSUPER 10.8 +161.8 161805 0.2 CTCF PKNOX1 CBX3 SIN3A ZNF2 THRB RAD21 ZBTB48 POLR2A SCRT2 LMOD1 GPR37L1 TIMM17A ARL8A PTPN7 ENSG00000273478 MIR6740
GH01G202213 0.8 Ensembl dbSUPER 11.1 -52.7 -52684 0.8 CTCF HDAC2 SCRT2 KDM1A RBBP5 EZH2 LGR6 PTPRVP PTPN7 ARL8A GC01M202216
GH01G202214 0.8 ENCODE dbSUPER 11.1 -52.0 -51996 0.2 CTCF ZNF10 HES1 RAD21 TCF7L2 ZNF18 EZH2 PTPRVP PTPN7 ARL8A LGR6 GC01M202216
GH01G202207 0.8 dbSUPER 11.1 -48.7 -48675 6.4 AGO1 RAD21 SCRT2 KLF13 EGR2 ZNF680 REST ZNF623 ZNF518A ZNF781 LGR6 PTPRVP PTPN7 ARL8A IPO9-AS1 IPO9 ENSG00000235121 GC01M202216
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTPN7 on UCSC Golden Path with GeneCards custom track

Promoters for PTPN7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000018251 1292 601 HDGF PKNOX1 ATF1 ARNT WRNIP1 YY1 ZNF121 CBX5 GATA2 ZNF143

Genomic Location for PTPN7 Gene

Chromosome:
1
Start:
202,147,012 bp from pter
End:
202,161,592 bp from pter
Size:
14,581 bases
Orientation:
Minus strand

Genomic View for PTPN7 Gene

Genes around PTPN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN7 Gene

Proteins for PTPN7 Gene

  • Protein details for PTPN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35236-PTN7_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 7
    Protein Accession:
    P35236
    Secondary Accessions:
    • B3KXE1
    • Q53XK4
    • Q5SXQ0
    • Q5SXQ1
    • Q9BV05

    Protein attributes for PTPN7 Gene

    Size:
    360 amino acids
    Molecular mass:
    40529 Da
    Quaternary structure:
    • Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases.
    SequenceCaution:
    • Sequence=AAA59531.1; Type=Frameshift; Positions=5; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPN7 Gene

    Alternative splice isoforms for PTPN7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPN7 Gene

Selected DME Specific Peptides for PTPN7 Gene

P35236:
  • YIATQGP
  • VVHCSAG
  • DYINANY
  • RYKTILPNP
  • GRTGCFI
  • HCSAGIGR
  • PIVVHCS
  • LQERRGS

Post-translational modifications for PTPN7 Gene

  • Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H(2)O(2)) or with antigen enhanced oxidation of active site cysteine (By similarity).
  • Phosphorylated on serine residues in resting T-cells. Phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels. Phosphorylation leads to dissociation of bound MAP kinases.
  • Ubiquitination at Lys103, isoforms=2, 3226, isoforms=2, 3248, and isoforms=2, 3312
  • Modification sites at PhosphoSitePlus

Domains & Families for PTPN7 Gene

Gene Families for PTPN7 Gene

Graphical View of Domain Structure for InterPro Entry

P35236

UniProtKB/Swiss-Prot:

PTN7_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with PTPN7: view

Function for PTPN7 Gene

Molecular function for PTPN7 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,non receptor type 7,stress-induced,expressed in hematopoietic cells
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited in cells after FCER1A triggering.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.

Enzyme Numbers (IUBMB) for PTPN7 Gene

Gene Ontology (GO) - Molecular Function for PTPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 10415025
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTPN7: view
genes like me logo Genes that share phenotypes with PTPN7: view

Animal Models for PTPN7 Gene

MGI Knock Outs for PTPN7:

Animal Model Products

CRISPR Products

miRNA for PTPN7 Gene

miRTarBase miRNAs that target PTPN7

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPN7 Gene

Localization for PTPN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN7 Gene

Cytoplasm. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPN7 gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 3
mitochondrion 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,TAS 10940933
GO:0005829 cytosol IDA 10940933
GO:0005856 cytoskeleton IEA --
GO:0009898 cytoplasmic side of plasma membrane IDA 10940933
genes like me logo Genes that share ontologies with PTPN7: view

Pathways & Interactions for PTPN7 Gene

genes like me logo Genes that share pathways with PTPN7: view

Pathways by source for PTPN7 Gene

1 GeneGo (Thomson Reuters) pathway for PTPN7 Gene
1 Qiagen pathway for PTPN7 Gene

SIGNOR curated interactions for PTPN7 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PTPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS,IEA 1530918
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with PTPN7: view

Drugs & Compounds for PTPN7 Gene

(4) Drugs for PTPN7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
cyclic amp Experimental Pharma 0

(1) Additional Compounds for PTPN7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PTPN7: view

Transcripts for PTPN7 Gene

Unigene Clusters for PTPN7 Gene

Protein tyrosine phosphatase, non-receptor type 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - -
SP13: - - - -
SP14: -
SP15: -

Relevant External Links for PTPN7 Gene

GeneLoc Exon Structure for
PTPN7
ECgene alternative splicing isoforms for
PTPN7

Expression for PTPN7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTPN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPN7 Gene

This gene is overexpressed in Whole Blood (x12.7), Spleen (x4.6), and Brain - Putamen (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for PTPN7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.2) and Lymph node (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTPN7 Gene



Protein tissue co-expression partners for PTPN7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PTPN7 Gene:

PTPN7

SOURCE GeneReport for Unigene cluster for PTPN7 Gene:

Hs.402773

mRNA Expression by UniProt/SwissProt for PTPN7 Gene:

P35236-PTN7_HUMAN
Tissue specificity: Expressed exclusively in thymus and spleen.

Evidence on tissue expression from TISSUES for PTPN7 Gene

  • Blood(4.7)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with PTPN7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPN7 Gene

Orthologs for PTPN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPN7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPN7 34 35
  • 99.38 (n)
mouse
(Mus musculus)
Mammalia Ptpn7 34 16 35
  • 88.95 (n)
dog
(Canis familiaris)
Mammalia PTPN7 34 35
  • 88.52 (n)
rat
(Rattus norvegicus)
Mammalia Ptpn7 34
  • 88.3 (n)
oppossum
(Monodelphis domestica)
Mammalia PTPN7 35
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPN7 34 35
  • 85.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTPN7 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPN7 34 35
  • 70.32 (n)
lizard
(Anolis carolinensis)
Reptilia PTPN7 35
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42327 35
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M04G7.2 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTP1 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for PTPN7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PTPN7 Gene

ENSEMBL:
Gene Tree for PTPN7 (if available)
TreeFam:
Gene Tree for PTPN7 (if available)

Paralogs for PTPN7 Gene

Variants for PTPN7 Gene

Sequence variations from dbSNP and Humsavar for PTPN7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000434821 -- 202,162,125(+) GGTAG(C/T)GGGGG upstream-variant-2KB
rs1000493902 -- 202,158,468(+) CAATC(C/T)TCCCA intron-variant
rs1000543952 -- 202,153,788(+) ATCTG(A/G)AAGGG nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime
rs1000602285 -- 202,152,834(+) GTTGC(A/C)ATTTT intron-variant
rs1001040410 -- 202,163,276(+) AGGAA(A/G)GAGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PTPN7 Gene

Variant ID Type Subtype PubMed ID
nsv467972 CNV loss 19166990
nsv522841 CNV gain 19592680
nsv548999 CNV loss 21841781

Variation tolerance for PTPN7 Gene

Residual Variation Intolerance Score: 65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.96; 93.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPN7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPN7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN7 Gene

Disorders for PTPN7 Gene

Relevant External Links for PTPN7

Human Genome Epidemiology (HuGE) Navigator
PTPN7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPN7

No disorders were found for PTPN7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPN7 Gene

Publications for PTPN7 Gene

  1. Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP. (PMID: 1510684) Adachi M. … Yachi A. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 22 64
  2. Structure of the hematopoietic tyrosine phosphatase (HePTP) catalytic domain: structure of a KIM phosphatase with phosphate bound at the active site. (PMID: 16226275) Mustelin T. … Page R. (J. Mol. Biol. 2005) 3 4 22 64
  3. Inhibition of T cell signaling by mitogen-activated protein kinase- targeted hematopoietic tyrosine phosphatase (HePTP). (PMID: 10206983) Saxena M. … Mustelin T. (J. Biol. Chem. 1999) 3 4 22 64
  4. Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase. (PMID: 10559944) Saxena M. … Mustelin T. (Nat. Cell Biol. 1999) 3 4 22 64
  5. Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP). (PMID: 9624114) Saxena M. … Mustelin T. (J. Biol. Chem. 1998) 3 4 22 64

Products for PTPN7 Gene

Sources for PTPN7 Gene

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