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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PTPN6 Gene

protein-coding GIFtS: 72
GCID: GC12P007055

protein tyrosine phosphatase, non-receptor type 6

Explore 56 diseases affiliated with
PTPN6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 6¹ ²		Protein-Tyrosine Phosphatase SHP-1² ³
HCP¹ ² ³		SH-PTP1² ³
PTP-1C¹ ² ³		EC 3.1.3.48³ ⁸
HCPH¹ ²		HPTP1C²
SHP-1¹ ²		SHP-1L²
SHP1¹ ²		Hematopoietic Cell Phosphatase²
Hematopoietic Cell Protein-Tyrosine Phosphatase² ³		Tyrosine-Protein Phosphatase Non-Receptor Type 6²
Protein-Tyrosine Phosphatase 1C² ³		PTP1C³

External Ids:	HGNC: 9658¹	Entrez Gene: 5777²	Ensembl: ENSG00000111679⁷	OMIM: 176883⁵	UniProtKB: P29350³

Export aliases for PTPN6 gene to outside databases

Previous GC identifers: GC12M007143 GC12M007227 GC12P006935 GC12P006926 GC12P006911

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPN6:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be

signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic

cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which

act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP

is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways

in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of

phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which

encode distinct isoforms, have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PTN6_HUMAN, P29350

Function: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR.

The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against

interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key

role in hematopoiesis

summary for PTPN6:

Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups

from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of

kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. PTPs

are cysteine-dependent phosphatases that contain a conserved C[X]5R motif essential for enzymatic activity.

PTPs are currently divided into five subtypes; tyrosine-specific phosphatases (e.g. PTP1B), dual specificity

phosphatases (DSPs) (e.g. DUSP1), Cdc25 phosphatases (e.g. Cdc25A), myotubularin-related phosphatases (e.g.

MTMR13) and low molecular weight phosphatases (e.g. PTPase A). Perturbations in PTP activity has been

implicated in human diseases, including type II diabetes. PTPs have been identified as a negative regulator

of the insulin signaling by dephosphorylating phosphotyrosine residues of insulin receptor kinase. In

cancers, PTPs dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation.

Gene Wiki entry for PTPN6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009759.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTPN6 gene promoter:
STAT1 ATF-2 c-Jun NF-kappaB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTPN6 promoter sequence

Search SABiosciences Chromatin IP Primers for PTPN6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31

PTPN6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN6 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P007055: view genomic region (about GC identifiers)

Start:	7,055,631 bp from pter	End:	7,070,479 bp from pter
Size:	14,849 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PTN6_HUMAN, P29350 (See protein sequence)

Recommended Name: Tyrosine-protein phosphatase non-receptor type 6

Size: 595 amino acids; 67561 Da

Subunit: Monomer. Interacts with MTUS1 (By similarity). Interacts with MILR1 (tyrosine-phosphorylated). Interacts with

KIT (By similarity). Binds PTPNS1, LILRB1 and LILRB2. Interacts with FCRL2, FCRL3, FCRL4, CD300LF, CDK2 and CD84.

Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts (via SH2 1 domain) with ROS1; the interaction

is direct and promotes ROS1 dephosphorylation. Interacts with EGFR; inhibits EGFR-dependent activation of MAPK/ERK.

Interacts with LYN. Interacts with the tyrosine phosphorylated form of PDPK1

Subcellular location: Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with

angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1

6/10 PDB 3D structures from and Proteopedia for PTPN6 (see all 10):

1FPR (3D)

1GWZ (3D)

1X6C (3D)

2B3O (3D)

2RMX (3D)

2YU7 (3D)

Secondary accessions: A8K306 G3V0F8 Q969V8 Q9UK67

Alternative splicing: 4 isoforms: P29350-1 P29350-3 P29350-2 P29350-4

Explore the universe of human proteins at neXtProt for PTPN6: NX_P29350

Post-translational modifications:

Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity).

Phosphorylation at Tyr-564 enhances phosphatase activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P29350

4/13 DME Specific Peptides for PTPN6 (P29350) (see all 13)

GFWEEFE

PIIVHCS

WPDHGVP

VQTEAQY

PTPN6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_002822.2 NP_536858.1 NP_536859.1

ENSEMBL proteins:

ENSP00000443393 ENSP00000444805 ENSP00000382376 ENSP00000438740 ENSP00000326010

ENSP00000444337 ENSP00000441044 ENSP00000445646 ENSP00000440114 ENSP00000446345

ENSP00000415979 ENSP00000391592

Reactome Protein details: P29350
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant PTPN6 Protein
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PTPN6
	OriGene Purified Proteins (see all 2): PTPN6 OriGene Protein Over-expression Lysate (see all 2): PTPN6 OriGene Custom Protein Services for PTPN6
	GenScript Custom Purified and Recombinant Proteins Services for PTPN6
	Novus Biologicals PTPN6 Proteins Novus Biologicals PTPN6 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PTPN6
	Uscn Proteins for PTPN6

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	10940933
GO:0005829	cytosol	TAS	--
GO:0016020	membrane	TAS	10506221

PTPN6 for ontologies About GeneDecksing

PTPN6 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PTPN6
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for PTPN6 (SHP-1)
	OriGene Antibodies (see all 3): PTPN6 OriGene Custom Antibody Services for PTPN6
	GenScript Custom Superior Antibodies Services for PTPN6
	Novus Biologicals PTPN6 Antibodies
	Abcam antibodies for PTPN6
	Uscn Antibodies for PTPN6
	ThermoFisher Antibody for PTPN6

Assay Products for PTPN6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PTPN6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PTPN6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTPN6 for domains About GeneDecksing

5 InterPro domains/families:

IPR016130 Tyr_Pase_AS

IPR000242 Tyr_Pase_rcpt/non-rcpt

IPR000387 Tyr/Dual-sp_Pase

IPR000980 SH2

IPR012152 Tyr_Pase_non-rcpt_typ-6/11

Graphical View of Domain Structure for InterPro Entry P29350

ProtoNet protein and cluster: P29350

2 Blocks protein families:

IPB000242 Protein tyrosine phosphatase signature

IPB000980 SH2 domain signature

UniProtKB/Swiss-Prot: PTN6_HUMAN, P29350

Domain: The N-terminal SH2 domain functions as an auto-inhibitory domain, blocking the catalytic domain in the

ligand-free close conformation

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily

Similarity: Contains 2 SH2 domains

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PTN6_HUMAN, P29350

Function: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR.

The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against

interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key

role in hematopoiesis

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Genatlas biochemistry entry for PTPN6:

protein tyrosine phosphatase,non receptor type 6,with two SH2 domains,expressed in hematopoietic cells,overexpressed in

neutrophils cells from patients with severe congenital neutropenia (defective dephosphorylation of proteins involved

in signaling pathways)

Enzyme Number (IUBMB): EC 3.1.3.48¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PTPN6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN6
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PTPN6
		SwitchGear 3'UTR luciferase reporter plasmid: PTPN6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN6 (see all 7) OriGene shRNA RFP: PTPN6 OriGene siRNA: PTPN6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PTPN6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN6 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN6 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): PTPN6 (NM_080548)
		Sino Biological Human cDNA Clone for PTPN6
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PTPN6
		Search LifeMap BioReagents cell lines for PTPN6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN6

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001784	phosphotyrosine binding	--	--
GO:0004725	protein tyrosine phosphatase activity	TAS	--
GO:0004872	receptor activity	--	--
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	IDA	11266449
GO:0005515	protein binding	IPI	18802077

PTPN6 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for PTPN6:

Decreased focal adhesion (FA)

Increased cell death HMECs cel

Weaker migration

Animal Models:
15 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Ptpn6):

cellular	digestive/alimentary	endocrine/exocrine gland	growth/size	hematopoietic system
homeostasis/metabolism	immune system	integument	limbs/digits/tail	mortality/aging
nervous system	pigmentation	reproductive system	respiratory system	skeleton

PTPN6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/47 super-pathways (see all 47) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Interleukin receptor SHC signaling

	Interleukin receptor SHC signaling	1.00			Interleukin-3, 5 and GM-CSF signaling	0.57
	Interleukin-2 signaling	0.67			Signaling by Interleukins	0.25

Immune response CD16 signaling in NK cells

	Immune response CD16 signaling in NK cells	1.00			Immune response_Role of DAP12 receptors in NK cells	0.32
	Immune response_CD16 signaling in NK cells	0.99			Immune response Role of DAP12 receptors in NK cells	0.32

Immune response_IL-2 activation and signaling pathway

	Immune response IL-2 activation and signaling pathway	1.00			Immune response_IL-3 activation and signaling pathway	0.41
	Immune response_IL-2 activation and signaling pathway	1.00			Immune response IL-3 activation and signaling pathway	0.41

Development Thrombopoetin signaling via JAK-STAT pathway

	Development_Thrombopoetin signaling via JAK-STAT pathway	1.00			Jak/Stat Pathway	0.29
	Development Thrombopoetin signaling via JAK-STAT pathway	1.00

Regulation of IFNA signaling

	Regulation of IFNA signaling	1.00			Immune response IFN alpha/beta signaling pathway	0.71
	Immune response_IFN alpha/beta signaling pathway	0.71

Pathway sources
See GeneCards unified pathways
Show all pathways

5/10 EMD Millipore Pathways for PTPN6 (see all 10)

	Immune response CD16 signaling in NK cells
	Immune response Role of DAP12 receptors in NK cells
	Development EPO-induced Jak-STAT pathway
	Immune response IL-3 activation and signaling pathway
	Immune response IL-2 activation and signaling pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTPN6

	Erythropoietin Pathway
	Epithelial Adherens Junctions

3 Cell Signaling Technology (CST) Pathways for PTPN6

	Phosphatases
	Lymphocyte Signaling
	Jak/Stat Pathway

5/10 GeneGo (Thomson Reuters) Pathways for PTPN6 (see all 10)

	Immune response CD16 signaling in NK cells
	Immune response BCR pathway
	Immune response IFN alpha/beta signaling pathway
	Immune response IL-2 activation and signaling pathway
	Development Thrombopoetin signaling via JAK-STAT pathway

5/16 BioSystems Pathways for PTPN6 (see all 16)

	EGFR1 Signaling Pathway
	Kit Receptor Signaling Pathway
	IL-2 Signaling Pathway
	IL-5 Signaling Pathway
	IL-4 signaling Pathway

5/25 Reactome Pathways for PTPN6 (see all 25)

	Regulation of IFNA signaling
	Interferon alpha/beta signaling
	Costimulation by the CD28 family
	Platelet homeostasis
	Signal regulatory protein (SIRP) family interactions

5/6 Kegg Pathways (Kegg details for PTPN6) (see all 6):

	Adherens junction
	Jak-STAT signaling pathway
	Natural killer cell mediated cytotoxicity
	T cell receptor signaling pathway
	B cell receptor signaling pathway

PTPN6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTPN6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/220 Interacting proteins for PTPN6 (P29350^{1, 2, 3} ENSP00000391592⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 220)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KIR2DL3	P43628²^,³, ENSP00000342215⁴	MINT-8027387 MINT-8027432 MINT-74921 MINT-8027447 MINT-8035737 MINT-8035752 MINT-8035662 MINT-74922 MINT-8027357 MINT-8035632 MINT-8035647 MINT-8027372 MINT-74923 I2D: score=2 STRING: ENSP00000342215
EPOR	P19235²^,³, ENSP00000222139⁴	MINT-77967 MINT-74899 MINT-74949 MINT-77965 MINT-74951 MINT-73490 MINT-77964 MINT-77966 MINT-73504 MINT-73509 MINT-8037088 I2D: score=4 STRING: ENSP00000222139
CD33	P20138²^,³, ENSP00000262262⁴	MINT-8033935 MINT-8033882 MINT-8033951 MINT-8031385 MINT-8033908 I2D: score=5 STRING: ENSP00000262262
LAIR1	Q6GTX8²^,³, ENSP00000375622⁴	MINT-8033852 MINT-8038190 MINT-8033867 MINT-8038175 I2D: score=6 STRING: ENSP00000375622
FCGR2B	P31994²^,³, ENSP00000351497⁴	MINT-74919 MINT-8025643 MINT-8025659 I2D: score=3 STRING: ENSP00000351497

About this table

Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin	--	--
GO:0006470	protein dephosphorylation	IDA	11266449
GO:0006915	apoptotic process	TAS	10506221
GO:0007186	G-protein coupled receptor signaling pathway	TAS	7781604
GO:0007596	blood coagulation	TAS	--

PTPN6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PTPN6 for compounds About GeneDecksing

EMD Millipore small molecules for PTPN6:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for PTPN6

Compounds for PTPN6 available from Tocris Bioscience About this table

Compound	Action	CAS #
NSC 87877	Potent inhibitor of shp2 and shp1 PTP	[56990-57-9]

2 HMDB Compounds for PTPN6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10/44 Novoseek chemical compound relationships for PTPN6 gene (see all 44) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	87.7	618	7512963 (7), 18377662 (6), 7518460 (5), 9528781 (5) (see all 99)
phosphotyrosine	79.7	37	9148918 (3), 11994457 (2), 14699166 (2), 8691154 (2) (see all 26)
sodium orthovanadate	69.7	1	7518460 (1)
vanadate	61.7	7	18721821 (1), 8621771 (1), 15797259 (1), 17558712 (1) (see all 6)
sodium stibogluconate	60.8	14	11544330 (2), 19833736 (1), 18292540 (1), 19514839 (1) (see all 5)
inositol	56.6	11	9743328 (1), 10651806 (1), 11709085 (1), 9203414 (1) (see all 11)
5-aza-2'deoxycytidine	47.2	9	20196786 (2), 16871283 (1), 19379557 (1), 19551406 (1)
phenylarsine oxide	44.5	1	8691154 (1)
phosphatidylinositol	37.6	8	9452499 (2), 10508402 (1), 17647198 (1), 9045636 (1) (see all 7)
mg 132	35.7	2	14624462 (1), 18617527 (1)

Search CenterWatch for drugs/clinical trials and news about PTPN6 / PTN6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PTPN6 gene (3 alternative transcripts):

NM_002831.5 NM_080548.4 NM_080549.3

Unigene Cluster for PTPN6:

Protein tyrosine phosphatase, non-receptor type 6

Hs.63489 [show with all ESTs]

Unigene Representative Sequence: NM_080549

18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):

ENST00000543115 ENST00000544354 ENST00000542848 ENST00000543120 ENST00000399448(uc001qsa.1 uc010sfr.1)

ENST00000534900 ENST00000538318 ENST00000538715 ENST00000318974 ENST00000543744

ENST00000540740 ENST00000416215(uc010sfs.1) ENST00000545153 ENST00000536521

ENST00000535462 ENST00000541698 ENST00000542462 ENST00000542277

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PTPN6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN6
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PTPN6
		SwitchGear 3'UTR luciferase reporter plasmid: PTPN6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN6 (see all 7) OriGene shRNA RFP: PTPN6 OriGene siRNA: PTPN6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN6 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN6 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): PTPN6 (NM_080548)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTPN6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN6

Additional cDNA sequence:

AK223629.1 AK290421.1 AK298470.1 AK300167.1 AK308230.1 AK309037.1 AK313379.1 BC002523.2

BC007667.2 BT007390.1 M74903.1 M77273.1

20 DOTS entries:

DT.91826354 DT.100028513 DT.102841597 DT.99987797 DT.121157420 DT.92434526 DT.97847706 DT.100818081

DT.456224 DT.121157735 DT.40240693 DT.102841606 DT.121157541 DT.86855134 DT.91706785 DT.95323462

DT.100028514 DT.121157572 DT.86855135 DT.95251915

11 AceView cDNA sequences:

NM_002831 NM_080548 CR590933 BC002523 NM_080549 BC007667 M77273 M74903

BT007390 AF178946 X62055

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN6 (see all 21) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	·	3e	·	3f	·	3g	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	·	5e	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^
SP1:									-		-		-		-		-		-		-		-		-				-		-								-		-
SP2:																													-		-								-		-
SP3:																													-		-								-		-
SP4:																													-		-								-		-
SP5:																													-		-								-		-				-		-

ExUns:	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19a	·	19b	^	20a	·	20b	^	21a	·	21b
SP1:																	-		-										-
SP2:																	-		-										-
SP3:																	-		-
SP4:
SP5:

ECgene alternative splicing isoforms for PTPN6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PTPN6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCAGCCCT

About this image

PTPN6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PTPN6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTPN6

SOURCE GeneReport for Unigene cluster: Hs.63489

UniProtKB/Swiss-Prot: PTN6_HUMAN, P29350

Tissue specificity: Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells

SABiosciences Expression via Pathway-Focused PCR Arrays including PTPN6:

Protein Phosphatases in human mouse rat

Antifungal Response in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PTPN6 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PTPN6¹	protein tyrosine phosphatase, non-receptor type 6	75.17(n) 81.97(a)		427947 NM_001031484.1 NP_001026655.1
lizard (Anolis carolinensis)	Reptilia	PTPN6⁶ --	--	74(a) 32(a)	1 ↔ 1 possible ortholog	GL343218.1(4868-14340) GL343453.1(628363-660743)
zebrafish (Danio rerio)	Actinopterygii	BC044414.1²	--	75.19(n)		335573 BC044414.1
fruit fly (Drosophila melanogaster)	Insecta	csw⁶	corkscrew	25(a)	possible ortholog	X(1988267-2009734)
worm (Caenorhabditis elegans)	Secernentea	ptp-2³	PROTEIN-TYROSINE PHOSPHATASE	36(a) (best of 6)		II(5918677-5920933) --

ENSEMBL Gene Tree for PTPN6 (if available)
TreeFam Gene Tree for PTPN6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PTPN6 gene

PTPN7² PTPRH² PTPN22² PTPRO² PTPN11² PTPRJ² PTPRQ² PTPN18²

PTPN12² PTPN5² PTPRB² PTPRR²

5 SIMAP similar genes for PTPN6 using alignment to 10 protein entries: PTN6_HUMAN (see all proteins):

PTPN11 PTPRR GRAP2 PTPN7 PTPN1

PTPN6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113047371^1,2	C,	--	6917689(+)	`GGCGTG/AAGCCA`	2	--	us2k¹		1	WA	2
rs111913195^1,2	C,F	--	6917696(+)	`GCCACC/TGCGCC`	2	--	us2k¹		3	NA WA	6
rs58496147^1,2	C,	--	6917958(+)	`CCTGTT/CGAGCT`	2	--	us2k¹		2	WA	120
rs45463899^1,2	C,	--	6918083(+)	`AGCCAT/CGGTGA`	2	--	us2k¹		2	WA	120
rs77144595^1,2	F,	--	6918150(+)	`GGCAGA/GGGCCT`	2	--	us2k¹		1	WA	118
rs77790046^1,2	C,F,	--	6918280(+)	`TCTTGC/AAAGCA`	2	--	us2k¹		1	WA	118
rs73262885^1,2	C,F,	--	6918832(+)	`CAGACG/ATGTGG`	2	--	us2k¹		3	WA CSA	122
rs78416656^1,2	C,F,	--	6919125(+)	`CTCTCC/TGGAAG`	2	--	ut5¹		1	EA	120
rs11547853^1,2	C	--	6919309(+)	`CTTCCT/CGGCTC`	4	/P /L	mis¹ ese³		2	NA	4
rs75082862^1,2		--	6920179(+)	`TCCTCC/TGTCTG`	2	--	int¹		2	CSA WA	119

HapMap Linkage Disequilibrium report for PTPN6 (7055631 - 7070479 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PTPN6: --
Human Gene Mutation Database (HGMD): PTPN6

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PTPN6 for disorders           About GeneDecksing

OMIM gene information: 176883    OMIM disorders: --

20/56 diseases for PTPN6 (see all 56):    About MalaCards

langerhans-cell histiocytosis polycythemia vera hemophagocytic lymphohistiocytosis anaplastic large cell lymphoma

severe congenital neutropenia myeloid leukemia polycythemia lupus erythematosus

burkitt's lymphoma b-cell lymphomas hairy cell leukemia systemic lupus erythematosus

acute promyelocytic leukemia leukemia histiocytosis noonan syndrome

chronic myeloid leukemia lymphoblastic leukemia acute myeloid leukemia neutropenia

10/31 Novoseek disease relationships for PTPN6 gene (see all 31) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	32.7	2	11723252 (1), 10227457 (1)
leukemogenesis	25.9	5	15157317 (1), 11001933 (1), 18948549 (1)
leukemia	25.4	27	12657462 (3), 14619449 (3), 16780734 (3), 11583976 (2) (see all 13)
polycythemia	22.5	3	9121771 (1), 9414643 (1)
polycythemia vera	21.3	4	10390187 (2), 9121771 (1)
htlv-i infections	20.4	2	9520455 (1)
lymphoma	19.1	35	19950550 (7), 11583976 (3), 12657462 (3), 14619449 (3) (see all 8)
lymphoma t-cell	18.8	7	11021818 (4), 10457220 (1), 15870198 (1), 17718411 (1)
tumors	13	35	14624462 (3), 20090381 (3), 17239936 (2), 11834522 (2) (see all 18)
leukemia t-cell	11	2	17540846 (1), 14630083 (1)

Genetic Association Database (GAD): PTPN6
Human Genome Epidemiology (HuGE) Navigator: PTPN6 (2 documents)

Export disorders for PTPN6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PTPN6 gene, integrated from 9 sources (see all 594):
(articles sorted by number of sources associating them with PTPN6)

Utopia: connect your pdf to the dynamic
world of online information

Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity. (PubMed id 10497187)^{1, 2, 9} Jin Y.J.... Burakoff S.J. (1999)
The nuclear localization of 3'-phosphoinositide-depen dent kinase-1 is dependent on its association with the protein tyrosine phospha tase SHP-1. (PubMed id 19591923)^{1, 2, 9} Sephton C.F....Mousseau D.D. (2009)
Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage. (PubMed id 10574931)^{1, 2, 9} Yoshida K....Kufe D. (1999)
Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. (PubMed id 11414741)^{1, 2, 9} Lewis J.... Duckett C.S. (2001)
Isolation of a src homology 2-containing tyrosine phosphatase. (PubMed id 1736296)^{1, 2, 9} Plutzky J.... Rosenberg R.D. (1992)
Crystal structure of human protein-tyrosine phosphatase SHP-1. (PubMed id 12482860)^{1, 2, 9} Yang J....Zhou G.W. (2003)
Molecular cloning and characterization of SPAP1, an inhibitory receptor. (PubMed id 11162587)^{1, 2, 9} Xu M.-J.... Zhao Z.J. (2001)
Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1. (PubMed id 9774441)^{1, 2, 9} Yang J.... Zhou G.W. (1998)
Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein. (PubMed id 7781604)^{1, 2, 9} Li R.Y.... Chap H. (1995)
A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. (PubMed id 1652101)^{1, 2, 9} Shen S.H.... Chretien P. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5777	HGNC: 9658	AceView: PTPN6	Ensembl:ENSG00000111679	euGenes: HUgn5777
ECgene: PTPN6	Kegg: 5777	H-InvDB: PTPN6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PTPN6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PTPN6	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PTPN6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PTPN6 gene:
Search GeneIP for patents involving PTPN6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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In Situ Hybridization Assays from
Advanced Cell Diagnostics
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PTPN6 Gene

protein tyrosine phosphatase, non-receptor type 6

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PTPN6 Gene

protein tyrosine phosphatase, non-receptor type 6

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