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PTPN6 Gene

protein-coding GIFtS: 72

GC12P006911

protein tyrosine phosphatase, non-receptor type 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.1.3.48 ^³
HCP ^¹, ², ³
HCPH ^¹, ²
HPTP1C ^²
PTP-1C ^¹, ², ³
PTP1C ^³
SH-PTP1 ^², ³
SHP-1 ^¹, ²
SHP-1L ^²
SHP1 ^¹, ²

Descriptions
Hematopoietic cell protein-tyrosine phosphatase ^², ³
Protein-tyrosine phosphatase 1C ^², ³
Protein-tyrosine phosphatase SHP-1 ^³
hematopoietic cell phosphatase ^²
protein tyrosine phosphatase, non-receptor type 6 ^²

External Ids
HGNC: 9658¹
Entrez Gene: 5777²
UniProtKB: P29350³
Ensembl: ENSG00000111679⁷

Search outside databases for aliases for PTPN6 gene

Previous GC identifers: GC12M007143 GC12M007227 GC12P006935 GC12P006926

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PTPN6:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs

are known to be signaling molecules that regulate a variety of cellular processes including cell

growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP

contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding

domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed

primarily in hematopoietic cells, and functions as an important regulator of multiple signaling

pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a

wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively

spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by

RefSeq]

UniProtKB/Swiss-Prot: PTN6_HUMAN, P29350

Function: Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor

receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions

may interact with other cellular components to modulate its own phosphatase activity against

interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II

stimulation

Gene Wiki entry for PTPN6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PTPN6 gene

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31

PTPN6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P006911: (about GC identifiers)

Start:	6,926,001 bp from pter
End:	6,940,740 bp from pter
Size:	14,740 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009759.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PTN6_HUMAN, P29350 (See protein sequence)

Recommended Name: Tyrosine-protein phosphatase non-receptor type 6

Size: 595 amino acids; 67561 Da

Subunit: Monomer. Interacts with MTUS1 (By similarity). Binds PTPNS1, LILRB1 and LILRB2. Interacts

with FCRL2, FCRL3, FCRL4, CD300LF and CD84

Subcellular location: Cytoplasm. Nucleus (By similarity). Note=In neurons, translocates into the

nucleus after treatment with angiotensin II (By similarity)

PDB structures from and Proteopedia :

1FPR (3D)

1GWZ (3D)

1X6C (3D)

2B3O (3D)

2RMX (3D)

2YU7 (3D)

Secondary accessions: Q969V8

Alternative splicing: 3 isoforms: P29350-1 P29350-3 P29350-2

Post-translational modifications:

Phosphorylated on serine and tyrosine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_002822.2 NP_536858.1 NP_536859.1

ENSEMBL proteins:

ENSP00000326010 ENSP00000382376

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant PTPN6 Protein
	Sigma-Aldrich CompoZr ZFN for PTPN6
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PTPN6
	Recombinant Proteins from Abcam (SHP1)
	Human Recombinant Proteins from Abnova (PTPN6)

OriGene Purified Recombinant Human Protein: PTPN6

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	EXP	9774457
GO:0016020	membrane	TAS	10506221

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Antibodies for PTPN6:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of PTPN6
	Sigma-Aldrich Antibodies for PTPN6
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for PTPN6 (SHP-1)
	Antibodies from Abcam (SHP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PTPN6)
	Novus Biologicals Antibodies for PTPN6

Assays for PTPN6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P29350

ProtoNet protein and cluster: P29350

2 Blocks protein families:

IPB000242 Protein tyrosine phosphatase signature

IPB000980 SH2 domain signature

UniProtKB/Swiss-Prot: PTN6_HUMAN, P29350

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily

Similarity: Contains 2 SH2 domains

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PTPN6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PTPN6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002831

Applied Biosystems Silencer® siRNAs for PTPN6

Sigma-Aldrich siRNA and siRNA Panels for PTPN6

Sigma-Aldrich shRNA Panels and shRNA for PTPN6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PTPN6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002831
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002831
untagged cDNA clones in CMV expression vector (see all 5): NM_002831

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_080549

UniProtKB/Swiss-Prot: PTN6_HUMAN, P29350

Function: Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor

receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions

may interact with other cellular components to modulate its own phosphatase activity against

interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II

stimulation

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Enzyme Number (IUBMB): EC 3.1.3.48

Genatlas biochemistry entry for PTPN6:

protein tyrosine phosphatase,non receptor type 6,with two SH2 domains,expressed in hematopoietic

cells,overexpressed in neutrophils cells from patients with severe congenital neutropenia

(defective dephosphorylation of proteins involved in signaling pathways)

12 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Ptpn6):

cellular	digestive/alimentary	endocrine/exocrine gland	growth/size	hematopoietic system
immune system	life span-post-weaning/aging	limbs/digits/tail	pigmentation	respiratory system
skeleton	skin/coat/nails

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004725	protein tyrosine phosphatase activity	TAS	1732748
GO:0005515	protein binding	IPI	10660620
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/13 Sigma-Aldrich "Your Favorite Gene" Pathways for PTPN6 (Your Favorite Gene powered by Ingenuity) (see all 13 )

IL-4 Signaling
Natural Killer Cell Signaling
CD28 Signaling in T Helper Cells
CTLA4 Signaling in Cytotoxic T Lymphocytes
B Cell Receptor Signaling

GeneDecks PTPN6 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for PTPN6

5/184 Interacting proteins for PTPN6 (ENSP00000326010³ P29350^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 184 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EPOR	P19235²	STRING (score=.998) MINT-77967 MINT-74899 MINT-74949 MINT-77965 MINT-74951 MINT-73490 MINT-77964 MINT-77966 MINT-73504 MINT-73509
CD22	P20273¹	STRING (score=.999) EBI-78260, EBI-78277
LCK	P06239¹	STRING (score=.998) EBI-78260, EBI-1348
PILRA	Q9UKJ1¹	STRING (score=.869) EBI-78260, EBI-965833
TFG	Q92734²	STRING (score=.711) MINT-56663 MINT-56662 MINT-56658

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006470	protein amino acid dephosphorylation	TAS	1732748
GO:0006915	apoptosis	TAS	10506221
GO:0007165	signal transduction	TAS	10506221
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	7781604

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PTPN6

Sigma-Aldrich Small Molecules for PTPN6:

Inhibitor

Compounds for PTPN6 available from Tocris Bioscience

Compound	Action	CAS number
NSC 87877	Potent inhibitor of shp2 and shp1 PTP	[56990-57-9]

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10/21 Novoseek chemical compound relationships for PTPN6 gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	87.70	587	7512963 (7), 18377662 (6), 7518460 (5), 9528781 (5) (see all 99)
phosphotyrosine	79.55	36	9148918 (3), 11994457 (2), 14699166 (2), 8691154 (2) (see all 25)
sodium orthovanadate	65.83	1	7518460 (1)
vanadate	62.77	7	18721821 (1), 8621771 (1), 15797259 (1), 17558712 (1) (see all 6)
phosphatidylinositol	39.46	8	9452499 (2), 10508402 (1), 17647198 (1), 9045636 (1) (see all 7)
phenylalanine	15.64	3	18024433 (1), 9528781 (1), 11382764 (1)
gp 130	10.18	1	10800945 (1)
calcium	7.42	8	15133509 (1), 17046078 (1), 11207261 (1), 7781604 (1) (see all 7)
adp	6.24	2	7781604 (1), 8798377 (1)
phorbol	5.65	1	8197173 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PTPN6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PTPN6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002831

Sigma-Aldrich siRNA and siRNA Panels for PTPN6

Sigma-Aldrich shRNA Panels and shRNA for PTPN6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002831 NM_080548 NM_080549

REFSEQ mRNAs for PTPN6 gene (3 alternative transcripts):

NM_002831.5 NM_080548.4 NM_080549.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002831 NM_080548 NM_080549

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002831
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002831
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_002831

Additional cDNA sequence:

AK223629.1 AK290421.1 AK298470.1 AK300167.1 AK308230.1 AK309037.1 AK313379.1 BC002523.2

BC007667.2 BT007390.1 CR590933.1 M74903.1 M77273.1

21 DOTS entries:

DT.91826354 DT.100028513 DT.102841597 DT.99987797 DT.121157420 DT.92434526 DT.97847706 DT.456224

DT.100818081 DT.121157735 DT.40240693 DT.102841606 DT.121157541 DT.86855134 DT.91706785 DT.95251915

DT.95323462 DT.100028514 DT.121157572 DT.86855135 DT.95358331

11 AceView cDNA sequences:

BC002523 NM_002831 NM_080549 NM_080548 CR590933 AF178946 BC007667 M77273

M74903 BT007390 X62055

highest scoring ESTs for PTPN6:

BC002523 BC007667 BE242539 BM149649 BX383745 BX406117 BX415146 BX438678 M74903 M77273

Unigene Cluster for PTPN6:

Protein tyrosine phosphatase, non-receptor type 6

Hs.63489 [show with all ESTs]

Unigene Representative Sequence: NM_080549

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN6 (see all 21 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	·	3e	·	3f	·	3g	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	·	5e	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^
SP1:									-		-		-		-		-		-		-		-		-				-		-								-		-
SP2:																													-		-								-		-
SP3:																													-		-								-		-
SP4:																													-		-								-		-
SP5:																													-		-								-		-				-		-

ExUns:	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19a	·	19b	^	20a	·	20b	^	21a	·	21b
SP1:																	-		-										-
SP2:																	-		-										-
SP3:																	-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PTPN6

2 Ensembl transcripts including schematic representations:

ENST00000318974 ENST00000399448

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PTPN6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PTPN6

¹ / ² / ³

3 probe-sets matching PTPN6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
794_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X62055	0.80	1.00	0.91	1
206687_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002831	0.60	1.00	0.82	1
206687_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PTPN6 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTCAGCCCT

SOURCE GeneReport for Unigene cluster: Hs.63489
Expression variation in blood from EXPOLDB for PTPN6
UniProtKB/Swiss-Prot: PTN6_HUMAN, P29350
Tissue specificity: Isoform 1 is expressed in hematopoietic cells while isoform 2 is expressed in
non-hematopoietic cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PTPN6 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PTPN6¹	--	protein tyrosine phosphatase, non-receptor type 6	91.16(n) 96.11(a)	486717 XM_543844.2 XP_543844.2
chimpanzee (Pan troglodytes)	PTPN6¹	--	protein tyrosine phosphatase, non-receptor type 6	98.32(n) 98.49(a)	748032 XM_001163468.1 XP_001163468.1
cow (Bos taurus)	PTPN6¹	--	protein tyrosine phosphatase, non-receptor type 6	91.39(n) 95.95(a)	512312 XM_874075.2 XP_879168.1
rat (Rattus norvegicus)	Ptpn6¹	--	protein tyrosine phosphatase, non-receptor type 6	89.77(n) 94.13(a)	116689 NM_053908.1 NP_446360.1
mouse (Mus musculus)	Ptpn6^{1, 5}	6 (60.22 cM)⁵	protein tyrosine phosphatase, non-receptor type 6^{1, 5}	89.06(n)¹ 94.47(a)¹	15170¹ NM_001077705.1¹ NP_001071173.1¹ AK132509⁵ AK150509⁵ (see all 25)

About this table Species with no ortholog for PTPN6

ENSEMBL Gene Tree for PTPN6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for PTPN6 gene

ENSG00000217801² PTPN11²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/86 NCBI SNPs in PTPN6 are shown (see all 86 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 52)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs10744721^1,2	A,C	6929393(+)	`tagagA/Ttgggg`	2	--	int¹ ng5¹		0	--	--	--	--
--	rs10744722^1,2	A,C	6929394(+)	`agagtG/Tggggt`	2	--	ng5¹ int¹		0	--	--	--	--
	rs2301262^1,2	C,F	6926121(+)	`CCCTCC/TGCCGT`	1	--	ut5¹		4		EA NA	1424
--	rs10744723^1,2	A,C	6929418(+)	`CCAGGA/CTGGTC`	2	--	int¹ ng5¹		0	--	--	--	--
--	rs10735062^1,2	A,C	6929405(+)	`TTCACC/TATGTT`	2	--	int¹ ng5¹		0	--	--	--	--
	rs11064473^1,2	H	6928960(+)	`CATCTC/GTGAGT`	2	--	int¹ ng5¹		4		EU EA WA	404
--	rs11064474^1,2	A	6929428(+)	`CTCGAA/TCTCCT`	2	--	ng5¹ int¹		0	--	--	--	--
	rs1048598^1,2	H	6934339(+)	`CTTCGT/AGCTTT`	3	E/V	mis¹		5		MN EU EA WA	564
	rs2110072^1,2	A,C,F	6935896(+)	`CAGGGC/TTGTCT`	3	G/G	syn¹		1		MN	42
	rs2110071^1,2	A,C,F,H,O	6935837(+)	`CTTGCG/ATCCAG`	2	--	int¹		6		NA EA EU	572

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HapMap Linkage Disequilibrium images for PTPN6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 176883

10/30 Novoseek disease relationships for PTPN6 gene (see all 30 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	34.45	2	11723252 (1), 10227457 (1)
leukemogenesis	27.99	5	15157317 (1), 11001933 (1), 18948549 (1)
leukemia	27.48	27	12657462 (3), 14619449 (3), 16780734 (3), 11583976 (2) (see all 13)
polycythemia	24.48	3	9121771 (1), 9414643 (1)
polycythemia vera	23.73	4	10390187 (2), 9121771 (1)
htlv-i infections	21.82	2	9520455 (1)
lymphoma t-cell	13.89	7	11021818 (4), 10457220 (1), 15870198 (1), 17718411 (1)
lymphoma b-cell	13.75	8	11420468 (4), 15363033 (2)
leukemia t-cell	12.77	2	17540846 (1), 14630083 (1)
lymphoma	11.12	25	11583976 (3), 12657462 (3), 14619449 (3), 16389548 (2) (see all 7)

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1 PharmGKB disease relationship for PTPN6 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Genetic Association Database: PTPN6
Human Genome Epidemiology Navigator: PTPN6 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/508 PubMed articles for PTPN6 gene (see all 508 ):

Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein. (PubMed id 7781604)^{1, 3, 4} Li R.Y.... Chap H. (1995)
Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. (PubMed id 11414741)^{1, 3, 4} Lewis J.... Duckett C.S. (2001)
Isolation of a src homology 2-containing tyrosine phosphatase. (PubMed id 1736296)^{1, 3, 4} Plutzky J.... Rosenberg R.D. (1992)
Molecular cloning and characterization of SPAP1, an inhibitory receptor. (PubMed id 11162587)^{1, 3, 4} Xu M.-J.... Zhao Z.J. (2001)
Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1. (PubMed id 9774441)^{1, 3, 4} Yang J.... Zhou G.W. (1998)
A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. (PubMed id 1652101)^{1, 3, 4} Shen S.H.... Chretien P. (1991)
IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes. (PubMed id 15184070)^{3, 4} Sui L....Cao X. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor- mediated signaling in monocytes. (PubMed id 9842885)^{3, 4} Fanger N.A....Borges L. (1998)
High expression of inhibitory receptor SHPS-1 and its association with protein tyrosine phosphatase SHP-1 in macrophages. (PubMed id 9712903)^{3, 4} Veillette A.... Latour S. (1998)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5777	HGNC: 9658	AceView: PTPN6	Ensembl:ENSG00000111679	euGenes: HUgn5777
ECgene: PTPN6	H-InvDB: PTPN6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PTPN6	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PTPN6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PTPN6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PTPN6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PTPN6		Antibodies for PTPN6
	Explore super-pooled esiRNAs		Proteins for PTPN6
	Lentivirus-delivered shRNAs for PTPN6		Small molecules for PTPN6
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PTPN6)
	Antibodies (PTPN6)
	Chimera RNAi (PTPN6)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for PTPN6 (SHP-1)

	Recombinant Proteins (SHP1)
	Antibodies (SHP1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for PTPN6

	Drugs/Proteins for PTPN6
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PTPN6

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PTPN6 Gene at Home site.
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PTPN6 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for PTPN6

Summaries
for PTPN6

Genomic Location
for PTPN6

Proteins
for PTPN6

Protein Domains/
Families
for PTPN6

Gene Function
for PTPN6

Pathways & Interactions
for PTPN6

Drugs & Compounds
for PTPN6

Transcripts
for PTPN6

Expression
for PTPN6

Orthologs
for PTPN6

Paralogs
for PTPN6

SNPs/Variants
for PTPN6

Disorders & Mutations
for PTPN6

Medical News
for PTPN6

Publications
for PTPN6

Search for PTPN6

Genome Databases showing PTPN6

Other Databases showing PTPN6

Specialized Databases showing PTPN6

Licensable Technologies
for PTPN6

Services
for PTPN6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PTPN6 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor PTPN6

Summariesfor PTPN6

Genomic Locationfor PTPN6

Proteinsfor PTPN6

Protein Domains/Familiesfor PTPN6

Gene Functionfor PTPN6

Pathways & Interactionsfor PTPN6

Drugs & Compoundsfor PTPN6

Transcriptsfor PTPN6

Expression for PTPN6

Orthologsfor PTPN6

Paralogsfor PTPN6

SNPs/Variantsfor PTPN6

Disorders & Mutationsfor PTPN6

Medical Newsfor PTPN6

Publicationsfor PTPN6

Search for PTPN6

Genome Databases showing PTPN6

Other Databases showing PTPN6

Specialized Databases showing PTPN6

Licensable Technologiesfor PTPN6

Servicesfor PTPN6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PTPN6

Summaries
for PTPN6

Genomic Location
for PTPN6

Proteins
for PTPN6

Protein Domains/
Families
for PTPN6

Gene Function
for PTPN6

Pathways & Interactions
for PTPN6

Drugs & Compounds
for PTPN6

Transcripts
for PTPN6

Expression
for PTPN6

Orthologs
for PTPN6

Paralogs
for PTPN6

SNPs/Variants
for PTPN6

Disorders & Mutations
for PTPN6

Medical News
for PTPN6

Publications
for PTPN6

Licensable Technologies
for PTPN6

Services
for PTPN6