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Aliases for PTPN6 Gene

Aliases for PTPN6 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 6 2 3
  • Hematopoietic Cell Protein-Tyrosine Phosphatase 3 4
  • Protein-Tyrosine Phosphatase SHP-1 3 4
  • Protein-Tyrosine Phosphatase 1C 3 4
  • EC 3.1.3.48 4 63
  • SH-PTP1 3 4
  • PTP-1C 3 4
  • HCP 3 4
  • Tyrosine-Protein Phosphatase Non-Receptor Type 6 3
  • Hematopoietic Cell Phosphatase 3
  • HPTP1C 3
  • SHP-1L 3
  • SHP-1 3
  • PTP1C 4
  • SHP1 3
  • HCPH 3

External Ids for PTPN6 Gene

Previous GeneCards Identifiers for PTPN6 Gene

  • GC12M007143
  • GC12M007227
  • GC12P006935
  • GC12P006926
  • GC12P006911
  • GC12P007055

Summaries for PTPN6 Gene

Entrez Gene Summary for PTPN6 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPN6 Gene

PTPN6 (Protein Tyrosine Phosphatase, Non-Receptor Type 6) is a Protein Coding gene. Diseases associated with PTPN6 include cd45 deficiency and polycythemia. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRN.

UniProtKB/Swiss-Prot for PTPN6 Gene

  • Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

Tocris Summary for PTPN6 Gene

  • Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. PTPs are cysteine-dependent phosphatases that contain a conserved C[X]5R motif essential for enzymatic activity. PTPs are currently divided into five subtypes; tyrosine-specific phosphatases (e.g. PTP1B), dual specificity phosphatases (DSPs) (e.g. DUSP1), Cdc25 phosphatases (e.g. Cdc25A), myotubularin-related phosphatases (e.g. MTMR13) and low molecular weight phosphatases (e.g. PTPase A). Perturbations in PTP activity has been implicated in human diseases, including type II diabetes. PTPs have been identified as a negative regulator of the insulin signaling by dephosphorylating phosphotyrosine residues of insulin receptor kinase. In cancers, PTPs dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation.

Gene Wiki entry for PTPN6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN6 Gene

Genomics for PTPN6 Gene

Regulatory Elements for PTPN6 Gene

Genomic Location for PTPN6 Gene

Start:
6,946,468 bp from pter
End:
6,961,316 bp from pter
Size:
14,849 bases
Orientation:
Plus strand

Genomic View for PTPN6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN6 Gene

Proteins for PTPN6 Gene

  • Protein details for PTPN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29350-PTN6_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 6
    Protein Accession:
    P29350
    Secondary Accessions:
    • A8K306
    • G3V0F8
    • Q969V8
    • Q9UK67

    Protein attributes for PTPN6 Gene

    Size:
    595 amino acids
    Molecular mass:
    67561 Da
    Quaternary structure:
    • Monomer. Interacts with MTUS1 (By similarity). Interacts with MILR1 (tyrosine-phosphorylated). Interacts with KIT (By similarity). Binds PTPNS1, LILRB1 and LILRB2. Interacts with FCRL2, FCRL3, FCRL4, CD300LF, CDK2 and CD84. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts (via SH2 1 domain) with ROS1; the interaction is direct and promotes ROS1 dephosphorylation. Interacts with EGFR; inhibits EGFR-dependent activation of MAPK/ERK. Interacts with LYN. Interacts with the tyrosine phosphorylated form of PDPK1.

    Three dimensional structures from OCA and Proteopedia for PTPN6 Gene

    Alternative splice isoforms for PTPN6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPN6 Gene

Proteomics data for PTPN6 Gene at MOPED

Post-translational modifications for PTPN6 Gene

  • Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity.
  • Ubiquitination at Lys277, Lys308, and Lys391
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTPN6 (SHP-1)

Protein Products

Domains for PTPN6 Gene

Gene Families for PTPN6 Gene

HGNC:
  • PTPN :Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor
  • SH2D :SH2 domain containing

Graphical View of Domain Structure for InterPro Entry

P29350

UniProtKB/Swiss-Prot:

PTN6_HUMAN :
  • P29350
Domain:
  • The N-terminal SH2 domain functions as an auto-inhibitory domain, blocking the catalytic domain in the ligand-free close conformation.
  • Contains 2 SH2 domains.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
genes like me logo Genes that share domains with PTPN6: view

Function for PTPN6 Gene

Molecular function for PTPN6 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,non receptor type 6,with two SH2 domains,expressed in hematopoietic cells,overexpressed in neutrophils cells from patients with severe congenital neutropenia (defective dephosphorylation of proteins involved in signaling pathways)
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

Enzyme Numbers (IUBMB) for PTPN6 Gene

Gene Ontology (GO) - Molecular Function for PTPN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine binding IEA --
GO:0004725 protein tyrosine phosphatase activity TAS --
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity IDA 11266449
GO:0005515 protein binding IPI 10206955
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPN6: view
genes like me logo Genes that share phenotypes with PTPN6: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN6

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PTPN6 Gene

Localization for PTPN6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN6 Gene

Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPN6 Gene COMPARTMENTS Subcellular localization image for PTPN6 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PTPN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 10940933
GO:0005829 cytosol TAS --
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with PTPN6: view

Pathways for PTPN6 Gene

genes like me logo Genes that share pathways with PTPN6: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation --
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin IEA --
GO:0006470 protein dephosphorylation IDA 11266449
GO:0006915 apoptotic process TAS 10506221
GO:0007186 G-protein coupled receptor signaling pathway TAS 7781604
genes like me logo Genes that share ontologies with PTPN6: view

Compounds for PTPN6 Gene

Compound Products

(5) Tocris Compounds for PTPN6 Gene

Compound Action Cas Number
BVT 948 Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling [39674-97-0]
NSC 87877 Potent inhibitor of shp2 and shp1 PTP [56990-57-9]
Sodium orthovanadate Protein tyrosine phosphatase inhibitor [13721-39-6]
TCS 401 Selective inhibitor of PTP1B [243966-09-8]
VO-OHpic Potent PTEN inhibitor [675848-25-6]

(1) ApexBio Compounds for PTPN6 Gene

Compound Action Cas Number
Etidronate [2809-21-4]

(2) HMDB Compounds for PTPN6 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(44) Novoseek inferred chemical compound relationships for PTPN6 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 87.7 239
phosphotyrosine 79.7 32
sodium orthovanadate 69.7 1
vanadate 61.7 6
sodium stibogluconate 60.8 6
genes like me logo Genes that share compounds with PTPN6: view

Transcripts for PTPN6 Gene

mRNA/cDNA for PTPN6 Gene

Unigene Clusters for PTPN6 Gene

Protein tyrosine phosphatase, non-receptor type 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^
SP1: - - - - - - - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - -
SP13: - - - - -
SP14: - - - - -
SP15: - - -
SP16: - - - -
SP17: - - - - - -
SP18: - - - - - - - - - - - - -
SP19: - -
SP20:
SP21:

ExUns: 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for PTPN6 Gene

GeneLoc Exon Structure for
PTPN6
ECgene alternative splicing isoforms for
PTPN6

Expression for PTPN6 Gene

mRNA expression in normal human tissues for PTPN6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPN6 Gene

This gene is overexpressed in Whole Blood (21.6) and Spleen (5.7).

Protein differential expression in normal tissues for PTPN6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.0), Lymph node (10.7), Blymphocyte (8.6), and Monocytes (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN6 Gene

SOURCE GeneReport for Unigene cluster for PTPN6 Gene Hs.63489

mRNA Expression by UniProt/SwissProt for PTPN6 Gene

P29350-PTN6_HUMAN
Tissue specificity: Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells
genes like me logo Genes that share expressions with PTPN6: view

Expression partners for PTPN6 Gene

In Situ Assay Products

Orthologs for PTPN6 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPN6 35
  • 91.41 (n)
  • 96.1 (a)
PTPN6 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPN6 35
  • 91.22 (n)
  • 96.11 (a)
PTPN6 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpn6 35
  • 89.13 (n)
  • 94.43 (a)
Ptpn6 16
Ptpn6 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPN6 35
  • 99.5 (n)
  • 99.83 (a)
PTPN6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpn6 35
  • 89.82 (n)
  • 94.13 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPN6 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPN6 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPN6 35
  • 75.17 (n)
  • 81.97 (a)
PTPN6 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPN6 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn6 35
  • 64.26 (n)
  • 63.4 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ptpn6 35
  • 64.3 (n)
  • 66.96 (a)
ptpn6 36
  • 58 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10340 35
fruit fly
(Drosophila melanogaster)
Insecta csw 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C55B7.3 37
  • 32 (a)
F47B3.1 37
  • 35 (a)
F47B3.6 37
  • 35 (a)
F47B3.7 37
  • 35 (a)
ptp-2 37
  • 36 (a)
Y48G9A.9 37
  • 34 (a)
ptp-2 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for PTPN6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN6 Gene

ENSEMBL:
Gene Tree for PTPN6 (if available)
TreeFam:
Gene Tree for PTPN6 (if available)

Paralogs for PTPN6 Gene

genes like me logo Genes that share paralogs with PTPN6: view

Variants for PTPN6 Gene

Sequence variations from dbSNP and Humsavar for PTPN6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs759051 -- 6,960,262(+) CCTGG(C/G)GGGGG intron-variant
rs759052 -- 6,960,457(+) GCCAC(C/T)GCCCG intron-variant
rs759053 -- 6,960,491(+) AGCCC(A/G)ATCCT intron-variant
rs1048596 -- 6,952,106(+) GGTGT(C/G/T)CTGCA reference, synonymous-codon, utr-variant-5-prime
rs1048597 -- 6,952,107(+) GTGTC(C/G)TGCAG reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PTPN6 Gene

Variant ID Type Subtype PubMed ID
nsv898641 CNV Loss 21882294
nsv509453 CNV Insertion 20534489
nsv513351 CNV Insertion 21212237
esv994245 CNV Insertion 20482838

Relevant External Links for PTPN6 Gene

HapMap Linkage Disequilibrium report
PTPN6
Human Gene Mutation Database (HGMD)
PTPN6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN6 Gene

Disorders for PTPN6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PTPN6 Gene in MalaCards »

(3) Diseases for PTPN6 Gene including...

(31) Novoseek inferred disease relationships for PTPN6 Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia 32.7 2
leukemogenesis 25.9 3
leukemia 25.4 23
polycythemia 22.5 2
polycythemia vera 21.3 3

Relevant External Links for PTPN6

Genetic Association Database (GAD)
PTPN6
Human Genome Epidemiology (HuGE) Navigator
PTPN6
genes like me logo Genes that share disorders with PTPN6: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for PTPN6 Gene

Publications for PTPN6 Gene

  1. Isolation of a src homology 2-containing tyrosine phosphatase. (PMID: 1736296) Plutzky J. … Rosenberg R.D. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  2. Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein. (PMID: 7781604) Li R.Y. … Chap H. (EMBO J. 1995) 3 4 23
  3. Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity. (PMID: 10497187) Jin Y.J. … Burakoff S.J. (J. Biol. Chem. 1999) 3 4 23
  4. Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage. (PMID: 10574931) Yoshida K. … Kufe D. (J. Biol. Chem. 1999) 3 4 23
  5. Crystal structure of human protein-tyrosine phosphatase SHP-1. (PMID: 12482860) Yang J. … Zhou G.W. (J. Biol. Chem. 2003) 3 4 23

Products for PTPN6 Gene

  • Addgene plasmids for PTPN6

Sources for PTPN6 Gene

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