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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPN5 Gene

protein-coding   GIFtS: 60
GCID: GC11M018706

protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
 Explore 2 diseases affiliated with
PTPN5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PTPN5    

Aliases
for PTPN5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched)1 2     Striatum-Enriched Protein-Tyrosine Phosphatase2 3
STEP1 2 3 5     EC 3.1.3.483 8
PTPSTEP1 2     Protein-Tyrosine Phosphatase Striatum-Enriched2
Neural-Specific Protein-Tyrosine Phosphatase2 3     Tyrosine-Protein Phosphatase Non-Receptor Type 52

External Ids:    HGNC: 96571   Entrez Gene: 848672   Ensembl: ENSG000001107867   OMIM: 1768795   UniProtKB: P548293   

Export aliases for PTPN5 gene to outside databases

Previous GC identifers: GC11U990112 GC11M019694 GC11M018788 GC11M018713 GC11M018434


Summaries
for PTPN5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PTN5_HUMAN, P54829
Function: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell
survival, including MAPKs, Src family kinases and NMDA receptors

Gene Wiki entry for PTPN5


Genomic Views
for PTPN5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPN5 gene promoter:
         CHOP-10   TBP   RP58   POU2F1   POU2F1a   Nkx2-5   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTPN5 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPN5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

PTPN5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M018706:  view genomic region     (about GC identifiers)

Start:
 18,749,475 bp from pter      End:
 18,814,268 bp from pter
Size:
 64,794 bases      Orientation:
 minus strand

Proteins
for PTPN5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PTN5_HUMAN, P54829 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 5  
Size: 565 amino acids; 63538 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Caution: It is uncertain whether Met-1 or Met-25 is the initiator
3 PDB 3D structures from and Proteopedia for PTPN5:
2BIJ (3D)        2BV5 (3D)        2CJZ (3D)    
Secondary accessions: B3KXG7 B7Z386 D3DQY7 Q6P1Z2 Q8N2A1 Q8NDP8
Alternative splicing: 2 isoforms:  P54829-1   P54829-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPN5: NX_P54829

Post-translational modifications:

  • Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the
    • phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P54829

    • 4/7 DME Specific Peptides for PTPN5 (P54829) (see all 7)
     GRTGCFI  LQERRGS  PIIVHCS  YIATQGP 

    PTPN5 Protein expression data from MOPED and PaxDb:    About this image 
    PTPN5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001035059.1  NP_008837.1  NP_116170.3  

    ENSEMBL proteins: 
     ENSP00000435056   ENSP00000351342   ENSP00000379469   ENSP00000379473   ENSP00000379471  
     ENSP00000379474   ENSP00000379470  

    Human Recombinant Protein Products for PTPN5: 
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    OriGene Purified Proteins (see all 2): PTPN5
    OriGene Protein Over-expression Lysate (see all 3): PTPN5
    OriGene Custom Protein Services for PTPN5 
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    Novus Biologicals PTPN5 Proteins
    Novus Biologicals PTPN5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PTPN5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane TAS2263249

    PTPN5 for ontologies           About GeneDecksing



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    Abcam antibodies for PTPN5 
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    ThermoFisher Antibodies for PTPN5

    Assay Products for PTPN5: 
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    Uscn ELISAs and CLIAs for PTPN5

    Protein Domains /
    Families
    for PTPN5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTPN5 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR016130 Tyr_Pase_AS
     IPR008356 Tyr_Pase_KIM-con
     IPR016334 Tyr_Pase_rcpt_R/non-rcpt_5
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry P54829

    ProtoNet protein and cluster: P54829

    1 Blocks protein family: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTN5_HUMAN, P54829
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Function
    for PTPN5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN5_HUMAN, P54829
    Function: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell
    survival, including MAPKs, Src family kinases and NMDA receptors
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN5:
    protein tyrosine phosphatase,non receptor type 5,homologous to murine striatum enriched phosphatase

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IDA16441242
    GO:0004725protein tyrosine phosphatase activity TAS7490079
    GO:0004872receptor activity ----
         
    PTPN5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PTPN5:
     Decreased focal adhesion (FA)   Increased apoptosis  Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ptpn5):
     nervous system 

    PTPN5 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Ptpn5tm1Pjlo for PTPN5
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PTPN5 

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): PTPN5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN5
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN5 (see all 35):
    hsa-miR-26a-2* hsa-miR-19b-2* hsa-miR-4272 hsa-miR-128 hsa-miR-632 hsa-miR-346 hsa-miR-4314 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: PTPN5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN5 (see all 7)
    OriGene shRNA RFP: PTPN5
    OriGene siRNA: PTPN5
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    Sirion Biotech Custom design and validation of potent shRNA sequences against PTPN5 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PTPN5 
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN5 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): PTPN5 (NM_032781)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN5


    Pathways & Interactions
    for PTPN5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    2Signal transduction Erk Interactions: Inhibition of Erk
    		Signal transduction Erk Interactions: Inhibition of Erk1.00
    		Signal transduction_Erk Interactions- Inhibition of Erk0.92
    3Phosphatases
    		Phosphatases1.00
    4Neuroscience
    		Neuroscience1.00
    5EGFR1 Signaling Pathway
    		EGFR1 Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PTPN5
        Signal transduction Erk Interactions- Inhibition of Erk

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPN5
        Epithelial Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for PTPN5
        Phosphatases
    Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for PTPN5
        Signal transduction Erk Interactions- Inhibition of Erk

    2 BioSystems Pathways for PTPN5 
        EGFR1 Signaling Pathway
    MAPK signaling pathway


    1         Kegg Pathway  (Kegg details for PTPN5):
        MAPK signaling pathway


    PTPN5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/17 Interacting proteins for PTPN5 (P548293 ENSP000003513424) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273613, ENSP000002630254I2D: score=3 STRING: ENSP00000263025
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    GRIN1Q055863I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS7490079
    GO:0035335peptidyl-tyrosine dephosphorylation ----

    PTPN5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTPN5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPN5

    1 HMDB Compound for PTPN5    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Search CenterWatch for drugs/clinical trials and news about PTPN5 / PTN5 

    Transcripts
    for PTPN5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTPN5 gene (3 alternative transcripts): 
    NM_001039970.1  NM_006906.1  NM_032781.3  

    Unigene Cluster for PTPN5:

    Protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
    Hs.79092  [show with all ESTs]
    Unigene Representative Sequence: AK127312
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477854 ENST00000358540(uc001mpb.3 uc001mpd.3 uc001mpc.3 uc010rdj.2 uc001mpf.3 uc001mpe.3 uc010rdk.2)
    ENST00000396166 ENST00000396170 ENST00000396168 ENST00000496201 ENST00000396171
    ENST00000396167

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): PTPN5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN5
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN5 (see all 35):
    hsa-miR-26a-2* hsa-miR-19b-2* hsa-miR-4272 hsa-miR-128 hsa-miR-632 hsa-miR-346 hsa-miR-4314 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: PTPN5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN5 (see all 7)
    OriGene shRNA RFP: PTPN5
    OriGene siRNA: PTPN5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN5
    Sirion Biotech Custom design and validation of potent shRNA sequences against PTPN5 
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK027333.1 AK055450.1 AK127312.1 AK294374.1 AK294673.1 AK295604.1 AK316270.1 AL832541.1 
    BC039897.1 BC046435.1 BC064807.1 

    9 DOTS entries:

    DT.97774012  DT.120711110  DT.95155037  DT.120711134  DT.95196224  DT.101978756  DT.308437  DT.95259666 
    DT.100019613 

    24/36 AceView cDNA sequences (see all 36):

    BX279922 BC046435 BC039897 AK027333 AK127312 BI668912 AK055450 BC064807 
    CA433334 BP348811 AI183359 AK090923 AL832541 BI757789 AX746685 BM543426 
    BI753754 NM_032781 F09602 BI754246 BI457969 BP347230 F06856 BF195091 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                    -                 -                                                           -                           
    SP2:                                      -                                                           -                           
    SP3:                    -     -           -                                                           -                           
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for PTPN5

    Expression
    for PTPN5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPN5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTATCTTG
    PTPN5 Expression
    About this image

    PTPN5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)

    See PTPN5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPN5

    SOURCE GeneReport for Unigene cluster: Hs.79092
        SABiosciences Expression via Pathway-Focused PCR Arrays including PTPN5: 
              Primary Cilia in human mouse rat
              Protein Phosphatases in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN5

    Orthologs
    for PTPN5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PTPN5 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PTPN51 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 67.37(n)
    72.17(a)    		   423085  XM_421017.3  XP_421017.2 
    lizard
    (Anolis carolinensis)    		 Reptilia PTPN56
    --
    		 --
    		 82(a)
    18(a)
    		 1 ↔ 1
    possible ortholog
    		 1(68040070-68072846)
    GL343585.1(197313-223844)
    zebrafish
    (Danio rerio)    		 Actinopterygii ptpn51 protein tyrosine phosphatase, non-receptor type 5 62.85(n)
    63.33(a)    		   559524  XM_682870.2  XP_687962.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta PTP-ER6
    CG423276
    (see all 3)    		 --
    		 7(a)
    6(a)
    (see all 3)    		 1 ↔ many
    possible ortholog
    (see all 3)    		 2R(17506889-17511947)
    3R(7481875-7499697)
    worm
    (Caenorhabditis elegans)    		 Secernentea ptp-26
    egg-56
    (see all 3)    		 Protein Tyrosine Phosphatase family member (ptp-2)...
    EGG sterile (unfertilizable) family member (egg-5)...
    (see all 3)    		 15(a)
    10(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 II(5918603-5921594)
    I(4168989-4171591)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATPTP16
    		 tyrosine phosphatase 1
    		 23(a)
    		 1 → many
    		 1(27026711-27029092)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 Protein-tyrosine phosphatase domain containing pro...
    Protein-tyrosine phosphatase domain containing pro...
    		 23(a)
    19(a)
    		 many ↔ many
    many ↔ many
    		 12(3791109-3796496)
    11(4000708-4008336)


    ENSEMBL Gene Tree for PTPN5 (if available)
    TreeFam Gene Tree for PTPN5 (if available) 

    Paralogs
    for PTPN5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPN5 gene
    PTPN72  PTPRH2  PTPN222  PTPRO2  PTPN112  PTPN62  PTPRJ2  PTPRQ2  
    PTPN182  PTPN122  PTPRB2  PTPRR2  
    18/42 SIMAP similar genes for PTPN5 using alignment to 7 protein entries:     PTN5_HUMAN (see all proteins) (see all similar genes):
    DKFZp781C1038    DKFZp686K0257    PTPRR    PTPN7    DKFZp686B1310    LAR
    PTPsigma    PTPRF    PTPRS    PTPRD    PTPRT    PTPRK
    DKFZp686C2268    PTPRM    PTPRU    PTPRZ1    PTPRH    PTPRB

    PTPN5 for paralogs           About GeneDecksing



    Genomic Variants
    for PTPN5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1138 NCBI SNPs in PTPN5 are shown (see all 1138)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1894212011,2
    		--18749174(+) ATCTGC/TTGGAA 4 -- int1 us2k10--------
    rs749290071,2
    		F--18749475(+) GGAGGT/ATAGTT 4 -- ut31 us2k11Minor allele frequency- A:0.04WA 118
    rs1382992231,2
    		--18749611(+) GATAAC/TACATG 4 -- ut31 us2k10--------
    rs1496100581,2
    		--18749661(+) ACACAC/TGCATG 4 -- ut31 us2k10--------
    rs1820206021,2
    		--18749834(+) CCCCAA/TCTGCC 3 -- ut310--------
    rs1172841701,2
    		--18750101(+) GTGTCC/TGGTAC 3 -- ut311Minor allele frequency- T:0.01EA 120
    rs79461051,2
    		C,F,A,H--18750165(+) TAGCAC/GGGAAA 3 -- ut3116Minor allele frequency- G:0.06NA NS EA WA CSA 1522
    rs1836937691,2
    		--18750309(+) TGTACA/GGTAGG 3 -- ut310--------
    rs1162437411,2
    		F--18750389(+) GAAGCG/AGGGAG 3 -- ut311Minor allele frequency- A:0.04WA 118
    rs1379200471,2
    		C--18750433(+) GGGCCA/GAGACT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for PTPN5 (18749475 - 18814268 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PTPN5: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for PTPN5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTPN5 for disorders           About GeneDecksing

    OMIM gene information: 176879    OMIM disorders: --

    2 diseases for PTPN5:    About MalaCards
    alzheimer's disease    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: PTPN5 (3 documents)

    Export disorders for PTPN5 gene to outside databases

    Publications
    for PTPN5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPN5 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with PTPN5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci. (PubMed id 7490079)1, 2, 9 Li X.... Francke U. (1995)
    2. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. (PubMed id 16441242)1, 2 Eswaran J.... Barr A.J. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum. (PubMed id 1714595)1, 3 Lombroso P.J....Lerner M. (1991)
    5. A critical role for protein tyrosine phosphatase nonre ceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes. (PubMed id 22649233)1 Yang C.H....Hsu K.S. (2012)
    6. Involvement of PTPN5, the gene encoding the striatal-e nriched protein tyrosine phosphatase, in schizophrenia and cognition. (PubMed id 22555153)1 Pelov I....Kohn Y. (2012)
    7. Reduced levels of the tyrosine phosphatase STEP block I^ amyloid-mediated GluA1/GluA2 receptor internalization. (PubMed id 21883219)1 Zhang Y....Lombroso P.J. (2011)
    8. Dephosphorylation of specific sites in the kinase-specificity sequence domain leads to ubiquitin-mediated degradation of the tyrosine phosphatase STEP. (PubMed id 21777200)2 Mukherjee S.... Paul S. (2011)
    9. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for PTPN5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTPN5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84867 HGNC: 9657 AceView: PTPN5 Ensembl:ENSG00000110786 euGenes: HUgn84867
    ECgene: PTPN5 Kegg: 84867 H-InvDB: PTPN5

    Other Databases showing PTPN5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTPN5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPN5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PTPN5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTPN5 gene:
    Search GeneIP for patents involving PTPN5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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