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Aliases for PTPN5 Gene

Aliases for PTPN5 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) 2 3
  • STEP 3 4 6
  • Striatum-Enriched Protein-Tyrosine Phosphatase 3 4
  • Neural-Specific Protein-Tyrosine Phosphatase 3 4
  • EC 4 63
  • Tyrosine-Protein Phosphatase Non-Receptor Type 5 3
  • Protein-Tyrosine Phosphatase Striatum-Enriched 3

External Ids for PTPN5 Gene

Previous GeneCards Identifiers for PTPN5 Gene

  • GC11U990112
  • GC11M019694
  • GC11M018788
  • GC11M018713
  • GC11M018706
  • GC11M018434

Summaries for PTPN5 Gene

GeneCards Summary for PTPN5 Gene

PTPN5 (Protein Tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched)) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and PAK Pathway. GO annotations related to this gene include protein tyrosine phosphatase activity and phosphotyrosine binding. An important paralog of this gene is PTPRO.

UniProtKB/Swiss-Prot for PTPN5 Gene

  • May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.

Gene Wiki entry for PTPN5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN5 Gene

Genomics for PTPN5 Gene

Regulatory Elements for PTPN5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPN5 Gene

18,727,928 bp from pter
18,792,721 bp from pter
64,794 bases
Minus strand

Genomic View for PTPN5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN5 Gene

Proteins for PTPN5 Gene

  • Protein details for PTPN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 5
    Protein Accession:
    Secondary Accessions:
    • B3KXG7
    • B7Z386
    • B7ZAF5
    • D3DQY7
    • Q6P1Z2
    • Q8N2A1
    • Q8NDP8

    Protein attributes for PTPN5 Gene

    565 amino acids
    Molecular mass:
    63538 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPN5 Gene

    Alternative splice isoforms for PTPN5 Gene


neXtProt entry for PTPN5 Gene

Proteomics data for PTPN5 Gene at MOPED

Selected DME Specific Peptides for PTPN5 Gene

Post-translational modifications for PTPN5 Gene

  • Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTPN5 (STEP)

Domains for PTPN5 Gene

Gene Families for PTPN5 Gene

  • PTPN :Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

Graphical View of Domain Structure for InterPro Entry



  • P54829
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with PTPN5: view

Function for PTPN5 Gene

Molecular function for PTPN5 Gene

GENATLAS Biochemistry: protein tyrosine phosphatase,non receptor type 5,homologous to murine striatum enriched phosphatase
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.

Enzyme Numbers (IUBMB) for PTPN5 Gene

Gene Ontology (GO) - Molecular Function for PTPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine binding IDA 16441242
GO:0004725 protein tyrosine phosphatase activity TAS 7490079
GO:0005515 protein binding IPI 25416956
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPN5: view

Phenotypes for PTPN5 Gene

genes like me logo Genes that share phenotypes with PTPN5: view

Animal Models for PTPN5 Gene

MGI Knock Outs for PTPN5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN5

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PTPN5 Gene

Localization for PTPN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PTPN5 Gene COMPARTMENTS Subcellular localization image for PTPN5 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for PTPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane TAS 2263249
genes like me logo Genes that share ontologies with PTPN5: view

Pathways for PTPN5 Gene

genes like me logo Genes that share pathways with PTPN5: view

Pathways by source for PTPN5 Gene

1 Qiagen pathway for PTPN5 Gene
2 Cell Signaling Technology pathways for PTPN5 Gene
2 BioSystems pathways for PTPN5 Gene
1 KEGG pathway for PTPN5 Gene
1 GeneGo (Thomson Reuters) pathway for PTPN5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 7490079
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 7490079
genes like me logo Genes that share ontologies with PTPN5: view

Compounds for PTPN5 Gene

(1) HMDB Compounds for PTPN5 Gene

Compound Synonyms Cas Number PubMed IDs
  • NFB Orthophosphate
genes like me logo Genes that share compounds with PTPN5: view

Transcripts for PTPN5 Gene

Unigene Clusters for PTPN5 Gene

Protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - -
SP3: - - - -

Relevant External Links for PTPN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPN5 Gene

mRNA expression in normal human tissues for PTPN5 Gene

mRNA differential expression in normal tissues according to GTEx for PTPN5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (13.2), Brain - Putamen (basal ganglia) (12.4), and Brain - Caudate (basal ganglia) (10.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTPN5 Gene

SOURCE GeneReport for Unigene cluster for PTPN5 Gene Hs.79092

genes like me logo Genes that share expressions with PTPN5: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PTPN5 Gene

Orthologs for PTPN5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTPN5 35
  • 99.59 (n)
  • 99.65 (a)
PTPN5 36
  • 100 (a)
(Bos Taurus)
Mammalia PTPN5 35
  • 90.54 (n)
  • 91.65 (a)
PTPN5 36
  • 92 (a)
(Canis familiaris)
Mammalia PTPN5 35
  • 89.97 (n)
  • 90.45 (a)
PTPN5 36
  • 91 (a)
(Mus musculus)
Mammalia Ptpn5 35
  • 88.66 (n)
  • 90.02 (a)
Ptpn5 16
Ptpn5 36
  • 90 (a)
(Monodelphis domestica)
Mammalia PTPN5 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia PTPN5 36
  • 84 (a)
(Rattus norvegicus)
Mammalia Ptpn5 35
  • 90.06 (n)
  • 94.85 (a)
(Gallus gallus)
Aves PTPN5 35
  • 67.18 (n)
  • 71.98 (a)
PTPN5 36
  • 70 (a)
(Anolis carolinensis)
Reptilia PTPN5 36
  • 69 (a)
(Danio rerio)
Actinopterygii ptpn5 35
  • 62.85 (n)
  • 63.33 (a)
ptpn5 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42327 36
  • 10 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTP1 36
  • 27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2178 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for PTPN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTPN5 Gene

Gene Tree for PTPN5 (if available)
Gene Tree for PTPN5 (if available)

Paralogs for PTPN5 Gene

Paralogs for PTPN5 Gene

genes like me logo Genes that share paralogs with PTPN5: view

Variants for PTPN5 Gene

Sequence variations from dbSNP and Humsavar for PTPN5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs751002 -- 18,745,535(+) CTCTG(C/T)TCCCC intron-variant
rs751003 -- 18,745,674(+) CATCA(G/T)CAGCA intron-variant
rs755795 -- 18,755,457(+) GCAAG(C/T)GGTTT intron-variant
rs755796 -- 18,755,624(+) GGACT(A/G)ATGCA intron-variant
rs755797 -- 18,755,646(+) AATCT(C/T)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPN5 Gene

Variant ID Type Subtype PubMed ID
nsv897028 CNV Loss 21882294
nsv525192 CNV Loss 19592680
nsv525452 CNV Gain 19592680

Relevant External Links for PTPN5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN5 Gene

Disorders for PTPN5 Gene

Relevant External Links for PTPN5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PTPN5: view

No data available for UniProtKB/Swiss-Prot for PTPN5 Gene

Publications for PTPN5 Gene

  1. Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci. (PMID: 7490079) Li X. … Francke U. (Genomics 1995) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum. (PMID: 1714595) Lombroso P.J. … Lerner M. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3
  4. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. (PMID: 16441242) Eswaran J. … Barr A.J. (Biochem. J. 2006) 3 4
  5. Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability. (PMID: 19000305) Korff S. … Gebert J. (BMC Cancer 2008) 3 48

Products for PTPN5 Gene

  • Addgene plasmids for PTPN5

Sources for PTPN5 Gene

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