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PTPN5 Gene

protein-coding   GIFtS: 61
GCID: GC11M018749

Protein Tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 5
(Striatum-Enriched)1 2
     EC 3.1.3.483 8
STEP2 3 5     PTPSTEP2
Neural-Specific Protein-Tyrosine Phosphatase2 3     Protein-Tyrosine Phosphatase Striatum-Enriched2
Striatum-Enriched Protein-Tyrosine Phosphatase2 3     Tyrosine-Protein Phosphatase Non-Receptor Type 52

External Ids:    HGNC: 96571   Entrez Gene: 848672   Ensembl: ENSG000001107867   OMIM: 1768795   UniProtKB: P548293   

Export aliases for PTPN5 gene to outside databases

Previous GC identifers: GC11U990112 GC11M019694 GC11M018788 GC11M018713 GC11M018706 GC11M018434


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PTPN5 Gene:
PTPN5 (protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)) is a protein-coding gene. GO annotations related to this gene include phosphotyrosine binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRQ.

UniProtKB/Swiss-Prot: PTN5_HUMAN, P54829
Function: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal
cell survival, including MAPKs, Src family kinases and NMDA receptors

Gene Wiki entry for PTPN5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPN5 gene promoter:
         CHOP-10   TBP   RP58   POU2F1   POU2F1a   Nkx2-5   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN5 promoter sequence
   Search Chromatin IP Primers for PTPN5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

PTPN5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M018749:  view genomic region     (about GC identifiers)

Start:
18,749,475 bp from pter      End:
18,814,268 bp from pter
Size:
64,794 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PTN5_HUMAN, P54829 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 5  
Size: 565 amino acids; 63538 Da
Caution: It is uncertain whether Met-1 or Met-25 is the initiator
3 PDB 3D structures from and Proteopedia for PTPN5:
2BIJ (3D)        2BV5 (3D)        2CJZ (3D)    
Secondary accessions: B3KXG7 B7Z386 D3DQY7 Q6P1Z2 Q8N2A1 Q8NDP8
Alternative splicing: 2 isoforms:  P54829-1   P54829-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPN5: NX_P54829

Explore proteomics data for PTPN5 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes
    the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active
    phosphatase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTPN5 (P54829) (see all 7)
     GRTGCFI  LQERRGS  PIIVHCS  YIATQGP 


    See PTPN5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001035059.1  NP_001265165.1  NP_001265167.1  NP_001265168.1  NP_008837.1  NP_116170.3  

    ENSEMBL proteins: 
     ENSP00000435056   ENSP00000351342   ENSP00000379469   ENSP00000379473   ENSP00000379471  
     ENSP00000379474   ENSP00000379470  

    PTPN5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PTPN5

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    5 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR008356 Tyr_Pase_KIM-con
     IPR016334 Tyr_Pase_rcpt_R/non-rcpt_5
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry P54829

    ProtoNet protein and cluster: P54829

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTN5_HUMAN, P54829
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPN5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN5_HUMAN, P54829
    Function: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal
    cell survival, including MAPKs, Src family kinases and NMDA receptors
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN5:
    protein tyrosine phosphatase,non receptor type 5,homologous to murine striatum enriched phosphatase

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IDA16441242
    GO:0004725protein tyrosine phosphatase activity TAS7490079
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with PTPN5           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PTPN5:
     Decreased focal adhesion (FA)   Increased apoptosis  Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ptpn5):
     nervous system 

    Find genes that share phenotypes with PTPN5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ptpn5tm1Pjlo for PTPN5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTPN5
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PTPN5 (see all 35):
    hsa-miR-26a-2* hsa-miR-19b-2* hsa-miR-4272 hsa-miR-128 hsa-miR-632 hsa-miR-346 hsa-miR-4314 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidPTPN5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PTPN5

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    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for PTPN5 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTN5_HUMAN, P54829: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    cytosol2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane TAS2263249

    Find genes that share ontologies with PTPN5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPN5 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2PAK Pathway
    Epithelial Adherens Junctions0.36
    3Signal transduction Erk Interactions Inhibition of Erk
    Signal transduction Erk Interactions Inhibition of Erk
    4Phosphatases
    Phosphatases
    5Neuroscience
    Neuroscience


    Find genes that share SuperPaths with PTPN5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPN5
        Epithelial Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for PTPN5
        Phosphatases
    Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for PTPN5
        Signal transduction Erk Interactions- Inhibition of Erk

    2 BioSystems Pathways for PTPN5
        MAPK signaling pathway
    EGFR1 Signaling Pathway


    1 Kegg Pathway  (Kegg details for PTPN5):
        MAPK signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTPN5: 
              Primary Cilia in human mouse rat
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPN5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTPN5 (P548293 ENSP000003513424) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273613, ENSP000002630254I2D: score=3 STRING: ENSP00000263025
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    GRIN1Q055863, ENSP000003606164I2D: score=2 STRING: ENSP00000360616
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS7490079
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation ----

    Find genes that share ontologies with PTPN5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPN5 (PTN5)

    1 HMDB Compound for PTPN5    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTPN5 gene (6 alternative transcripts): 
    NM_001039970.1  NM_001278236.1  NM_001278238.1  NM_001278239.1  NM_006906.1  NM_032781.3  

    Unigene Cluster for PTPN5:

    Protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
    Hs.79092  [show with all ESTs]
    Unigene Representative Sequence: AK127312
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477854 ENST00000358540(uc001mpb.3 uc001mpd.3 uc001mpc.3 uc010rdj.2 uc001mpf.3 uc001mpe.3 uc010rdk.2)
    ENST00000396166 ENST00000396170 ENST00000396168 ENST00000496201 ENST00000396171
    ENST00000396167
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PTPN5 (see all 35):
    hsa-miR-26a-2* hsa-miR-19b-2* hsa-miR-4272 hsa-miR-128 hsa-miR-632 hsa-miR-346 hsa-miR-4314 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidPTPN5 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for PTPN5 
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      QuantiFast Probe-based Assays in human, mouse, rat PTPN5

    Additional mRNA sequence: 

    AK027333.1 AK055450.1 AK127312.1 AK294374.1 AK294673.1 AK295604.1 AK316270.1 AL832541.1 
    BC039897.1 BC046435.1 BC064807.1 

    9 DOTS entries:

    DT.97774012  DT.120711110  DT.95155037  DT.95196224  DT.101978756  DT.308437  DT.120711134  DT.95259666 
    DT.100019613 

    Selected AceView cDNA sequences (see all 36):

    CA433334 AK127312 AK027333 BC039897 BX279922 BP348811 BC046435 BC064807 
    BI668912 AK055450 AK090923 BI754246 AX746685 BI757789 BI753754 AL832541 
    NM_032781 BI457969 BM543426 AI183359 F09602 F06856 F03121 BP347230 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                    -                 -                                                           -                           
    SP2:                                      -                                                           -                           
    SP3:                    -     -           -                                                           -                           
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for PTPN5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPN5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTATCTTG
    PTPN5 Expression
    About this image


    PTPN5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Spinal Cord (Nervous System)
    PTPN5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPN5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.79092
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTPN5: 
              Primary Cilia in human mouse rat
              Protein Phosphatases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat PTPN5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PTPN5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn51 , 5 protein tyrosine phosphatase, non-receptor type 51, 5 88.66(n)1
    90.02(a)1
      7 (30.70 cM)5
    192591  NM_001163565.11  NP_001157037.11 
     470777985 
    chicken
    (Gallus gallus)
    Aves PTPN51 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 67.18(n)
    71.98(a)
      423085  XM_421017.4  XP_421017.3 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN56
    protein tyrosine phosphatase, non-receptor type 5 ...
    69(a)
    1 ↔ 1
    1(68039261-68104629)
    zebrafish
    (Danio rerio)
    Actinopterygii ptpn51 protein tyrosine phosphatase, non-receptor type 5 62.85(n)
    63.33(a)
      559524  XM_682870.3  XP_687962.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423276
    --
    10(a)
    1 → many
    3R(7481875-7499697)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PTP16
    Phosphotyrosine-specific protein phosphatase that ...
    27(a)
    1 → many
    IV(42700-43707) YDL230W


    ENSEMBL Gene Tree for PTPN5 (if available)
    TreeFam Gene Tree for PTPN5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPN5 gene
    PTPRQ2  PTPRJ2  PTPN72  PTPRH2  PTPRB2  PTPRO2  PTPRR2  
    Selected SIMAP similar genes for PTPN5 using alignment to 7 protein entries:     PTN5_HUMAN (see all proteins) (see all similar genes):
    DKFZp781C1038    DKFZp686K0257    PTPRR    PTPN7    DKFZp686B1310    LAR
    PTPsigma    PTPRF    PTPRS    PTPRD    PTPRT    PTPRK
    DKFZp686C2268    PTPRM    PTPRU    PTPRQ    PTPRZ1    PTPRH

    Find genes that share paralogs with PTPN5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPN5 (see all 1387)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1820206021,2
    --18749834(+) CCCCAA/TCTGCC 3 -- ut310--------
    rs1172841701,2
    C,F--18750101(+) GTGTCC/TGGTAC 3 -- ut311Minor allele frequency- T:0.01EA 120
    rs79461051,2
    C,F,A,H--18750165(+) TAGCAC/GGGAAA 3 -- ut3116Minor allele frequency- G:0.06NA NS EA WA CSA 1522
    rs1836937691,2
    --18750309(+) TGTACA/GGTAGG 3 -- ut310--------
    rs1162437411,2
    F--18750389(+) GAAGCG/AGGGAG 3 -- ut311Minor allele frequency- A:0.04WA 118
    rs1379200471,2
    C--18750433(+) GGGCCA/GAGACT 3 -- ut310--------
    rs110247731,2,,4
    C,H--18750497(+) ACTGGT/CGGGAC 6 /H /R mis1 ese36Minor allele frequency- C:0.00NS EA NA 422
    rs2005264431,2
    C--18750515(+) TTTCGT/CAGAGG 6 /Y /C mis11Minor allele frequency- C:0.00EU 1323
    rs1459268891,2
    C--18750532(+) ACGTGA/GTGCAC 6 H syn10--------
    rs1116743281,2
    C--18750579(+) CCTGCC/ACGGCA 3 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for PTPN5 (18749475 - 18814268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PTPN5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525192CNV Loss19592680
    nsv897028CNV Loss21882294
    nsv525452CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTPN5
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPN5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176879    OMIM disorders: --


    Find genes that share disorders with PTPN5           About GenesLikeMe

    Genetic Association Database (GAD): PTPN5
    Human Genome Epidemiology (HuGE) Navigator: PTPN5 (3 documents)

    Export disorders for PTPN5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPN5 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with PTPN5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci. (PubMed id 7490079)1, 2, 9 Li X.... Francke U. (Genomics 1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability. (PubMed id 19000305)1, 4 Korff S....Gebert J. (BMC Cancer 2008)
    4. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. (PubMed id 16441242)1, 2 Eswaran J.... Barr A.J. (Biochem. J. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum. (PubMed id 1714595)1, 3 Lombroso P.J....Lerner M. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    7. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    8. A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes. (PubMed id 22649233)1 Yang C.H....Hsu K.S. (J. Neurosci. 2012)
    9. The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity. (PubMed id 22885232)1 Olausson P....Lombroso P.J. (Neuroscience 2012)
    10. Involvement of PTPN5, the gene encoding the striatal-enriched protein tyrosine phosphatase, in schizophrenia and cognition. (PubMed id 22555153)1 Pelov I....Kohn Y. (Psychiatr. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84867 HGNC: 9657 AceView: PTPN5 Ensembl:ENSG00000110786 euGenes: HUgn84867
    ECgene: PTPN5 Kegg: 84867 H-InvDB: PTPN5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPN5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPN5 gene:
    Search GeneIP for patents involving PTPN5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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