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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPN5 Gene

protein-coding   GIFtS: 62
GCID: GC11M018706

Protein Tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched)

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 5
(Striatum-Enriched)1 2
     EC 3.1.3.483 8
STEP2 3 5     PTPSTEP2
Neural-Specific Protein-Tyrosine Phosphatase2 3     Protein-Tyrosine Phosphatase Striatum-Enriched2
Striatum-Enriched Protein-Tyrosine Phosphatase2 3     Tyrosine-Protein Phosphatase Non-Receptor Type 52

External Ids:    HGNC: 96571   Entrez Gene: 848672   Ensembl: ENSG000001107867   OMIM: 1768795   UniProtKB: P548293   

Export aliases for PTPN5 gene to outside databases

Previous GC identifers: GC11U990112 GC11M019694 GC11M018788 GC11M018713 GC11M018434


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PTPN5 Gene: 
PTPN5 (protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)) is a protein-coding gene. Diseases associated with PTPN5 include alzheimer's disease, and schizophrenia, and among its related super-pathways are MAPK signaling pathway and Signal transduction Erk Interactions- Inhibition of Erk. GO annotations related to this gene include phosphotyrosine binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPN7.

UniProtKB/Swiss-Prot: PTN5_HUMAN, P54829
Function: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal
cell survival, including MAPKs, Src family kinases and NMDA receptors

Gene Wiki entry for PTPN5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPN5 gene promoter:
         CHOP-10   TBP   RP58   POU2F1   POU2F1a   Nkx2-5   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN5 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPN5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

PTPN5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M018706:  view genomic region     (about GC identifiers)

Start:
18,749,475 bp from pter      End:
18,814,268 bp from pter
Size:
64,794 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTN5_HUMAN, P54829 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 5  
Size: 565 amino acids; 63538 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Caution: It is uncertain whether Met-1 or Met-25 is the initiator
3 PDB 3D structures from and Proteopedia for PTPN5:
2BIJ (3D)        2BV5 (3D)        2CJZ (3D)    
Secondary accessions: B3KXG7 B7Z386 D3DQY7 Q6P1Z2 Q8N2A1 Q8NDP8
Alternative splicing: 2 isoforms:  P54829-1   P54829-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPN5: NX_P54829

Explore proteomics data for PTPN5 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes
    the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active
    phosphatase
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P54829

  • 4/7 DME Specific Peptides for PTPN5 (P54829) (see all 7)
     GRTGCFI  LQERRGS  PIIVHCS  YIATQGP 

    PTPN5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTPN5 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001035059.1  NP_001265165.1  NP_001265167.1  NP_001265168.1  NP_008837.1  NP_116170.3  

    ENSEMBL proteins: 
     ENSP00000435056   ENSP00000351342   ENSP00000379469   ENSP00000379473   ENSP00000379471  
     ENSP00000379474   ENSP00000379470  

    Human Recombinant Protein Products for PTPN5: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for PTPN5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane TAS2263249

    PTPN5 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for PTPN5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    5 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR008356 Tyr_Pase_KIM-con
     IPR016334 Tyr_Pase_rcpt_R/non-rcpt_5
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry P54829

    ProtoNet protein and cluster: P54829

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTN5_HUMAN, P54829
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    PTPN5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN5_HUMAN, P54829
    Function: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal
    cell survival, including MAPKs, Src family kinases and NMDA receptors
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN5:
    protein tyrosine phosphatase,non receptor type 5,homologous to murine striatum enriched phosphatase

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IDA16441242
    GO:0004725protein tyrosine phosphatase activity TAS7490079
    GO:0016791phosphatase activity ----
         
    PTPN5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PTPN5:
     Decreased focal adhesion (FA)   Increased apoptosis  Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ptpn5):
     nervous system 

    PTPN5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptpn5tm1Pjlo for PTPN5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTPN5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTPN5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPN5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPN5 

    miRNA
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    hsa-miR-26a-2* hsa-miR-19b-2* hsa-miR-4272 hsa-miR-128 hsa-miR-632 hsa-miR-346 hsa-miR-4314 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidPTPN5 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTPN5 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Signal transduction Erk Interactions: Inhibition of Erk
    Signal transduction Erk Interactions: Inhibition of Erk0.92
    3PAK Pathway
    Epithelial Adherens Junctions0.36
    4Phosphatases
    Phosphatases
    5Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PTPN5
        Signal transduction Erk Interactions- Inhibition of Erk

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPN5
        Epithelial Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for PTPN5
        Phosphatases
    Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for PTPN5
        Signal transduction Erk Interactions- Inhibition of Erk

    2 BioSystems Pathways for PTPN5
        MAPK signaling pathway
    EGFR1 Signaling Pathway


    1         Kegg Pathway  (Kegg details for PTPN5):
        MAPK signaling pathway


    PTPN5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/17 Interacting proteins for PTPN5 (P548293 ENSP000003513424) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273613, ENSP000002630254I2D: score=3 STRING: ENSP00000263025
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    GRIN1Q055863I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS7490079
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation ----

    PTPN5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPN5 (PTN5)

    1 HMDB Compound for PTPN5    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    Search CenterWatch for drugs/clinical trials and news about PTPN5 / PTN5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTPN5 gene (6 alternative transcripts): 
    NM_001039970.1  NM_001278236.1  NM_001278238.1  NM_001278239.1  NM_006906.1  NM_032781.3  

    Unigene Cluster for PTPN5:

    Protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
    Hs.79092  [show with all ESTs]
    Unigene Representative Sequence: AK127312
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477854 ENST00000358540(uc001mpb.3 uc001mpd.3 uc001mpc.3 uc010rdj.2 uc001mpf.3 uc001mpe.3 uc010rdk.2)
    ENST00000396166 ENST00000396170 ENST00000396168 ENST00000496201 ENST00000396171
    ENST00000396167

    miRNA
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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN5 (see all 35):
    hsa-miR-26a-2* hsa-miR-19b-2* hsa-miR-4272 hsa-miR-128 hsa-miR-632 hsa-miR-346 hsa-miR-4314 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidPTPN5 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK027333.1 AK055450.1 AK127312.1 AK294374.1 AK294673.1 AK295604.1 AK316270.1 AL832541.1 
    BC039897.1 BC046435.1 BC064807.1 

    9 DOTS entries:

    DT.97774012  DT.120711110  DT.95155037  DT.120711134  DT.95196224  DT.101978756  DT.308437  DT.95259666 
    DT.100019613 

    24/36 AceView cDNA sequences (see all 36):

    AK127312 BC046435 AK055450 AK027333 BP348811 CA433334 BC064807 BC039897 
    BI668912 BX279922 AI183359 AK090923 BI754246 F09602 NM_032781 AX746685 
    BI457969 BI757789 AL832541 BI753754 BM543426 BP347230 F06856 F03121 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                    -                 -                                                           -                           
    SP2:                                      -                                                           -                           
    SP3:                    -     -           -                                                           -                           
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for PTPN5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPN5 expression in normal human tissues (normalized intensities)      PTPN5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTATCTTG
    PTPN5 Expression
    About this image


    PTPN5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             striatum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle

    See PTPN5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPN5

    SOURCE GeneReport for Unigene cluster: Hs.79092
        SABiosciences Expression via Pathway-Focused PCR Arrays including PTPN5: 
              Primary Cilia in human mouse rat
              Protein Phosphatases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PTPN5 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn51 , 5 protein tyrosine phosphatase, non-receptor type 51, 5 88.66(n)1
    90.02(a)1
      7 (30.70 cM)5
    192591  NM_001163565.11  NP_001157037.11 
     470777985 
    chicken
    (Gallus gallus)
    Aves PTPN51 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 67.37(n)
    72.17(a)
      423085  XM_421017.3  XP_421017.2 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN56
    Uncharacterized protein
    69(a)
    1 ↔ 1
    1(68039261-68104629)
    zebrafish
    (Danio rerio)
    Actinopterygii ptpn51 protein tyrosine phosphatase, non-receptor type 5 62.85(n)
    63.33(a)
      559524  XM_682870.2  XP_687962.2 
    worm
    (Caenorhabditis elegans)
    Secernentea K07F5.86
    F10G8.16
    (see all 24)
    Protein F10G8.1, isoform a
    (see all 24)
    26(a)
    25(a)
    (see all 24)
    many ↔ many
    many ↔ many
    (see all 24)
    IV(9848483-9849724)
    I(10019706-10021087)


    ENSEMBL Gene Tree for PTPN5 (if available)
    TreeFam Gene Tree for PTPN5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPN5 gene
    PTPN72  PTPRR2  
    18/40 SIMAP similar genes for PTPN5 using alignment to 7 protein entries:     PTN5_HUMAN (see all proteins) (see all similar genes):
    DKFZp781C1038    DKFZp686K0257    PTPRR    PTPN7    DKFZp686B1310    LAR
    PTPsigma    PTPRF    PTPRS    PTPRD    PTPRT    PTPRK
    DKFZp686C2268    PTPRM    PTPRU    PTPRZ1    PTPRH    PTPRB

    PTPN5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1387 SNPs in PTPN5 are shown (see all 1387)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1820206021,2
    --18749834(+) CCCCAA/TCTGCC 3 -- ut310--------
    rs1172841701,2
    C,F--18750101(+) GTGTCC/TGGTAC 3 -- ut311Minor allele frequency- T:0.01EA 120
    rs79461051,2
    C,F,A,H--18750165(+) TAGCAC/GGGAAA 3 -- ut3116Minor allele frequency- G:0.06NA NS EA WA CSA 1522
    rs1836937691,2
    --18750309(+) TGTACA/GGTAGG 3 -- ut310--------
    rs1162437411,2
    F--18750389(+) GAAGCG/AGGGAG 3 -- ut311Minor allele frequency- A:0.04WA 118
    rs1379200471,2
    C--18750433(+) GGGCCA/GAGACT 3 -- ut310--------
    rs110247731,2,4
    C,H--18750497(+) ACTGGT/CGGGAC 6 /H /R mis1 ese36Minor allele frequency- C:0.00NS EA NA 422
    rs2005264431,2
    C--18750515(+) TTTCGT/CAGAGG 6 /Y /C mis11Minor allele frequency- C:0.00EU 1323
    rs1459268891,2
    C--18750532(+) ACGTGA/GTGCAC 6 H syn10--------
    rs1116743281,2
    C--18750579(+) CCTGCC/ACGGCA 3 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for PTPN5 (18749475 - 18814268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PTPN5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv525192CNV Loss19592680
    nsv897028CNV Loss21882294
    nsv525452CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176879    OMIM disorders: --

    3 diseases for PTPN5:    About MalaCards
    alzheimer's disease    schizophrenia    neuronitis


    PTPN5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): PTPN5
    Human Genome Epidemiology (HuGE) Navigator: PTPN5 (3 documents)

    Export disorders for PTPN5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPN5 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with PTPN5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci. (PubMed id 7490079)1, 2, 9 Li X.... Francke U. (1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability. (PubMed id 19000305)1, 4 Korff S....Gebert J. (2008)
    4. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. (PubMed id 16441242)1, 2 Eswaran J.... Barr A.J. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum. (PubMed id 1714595)1, 3 Lombroso P.J....Lerner M. (1991)
    7. A critical role for protein tyrosine phosphatase nonre ceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes. (PubMed id 22649233)1 Yang C.H....Hsu K.S. (2012)
    8. The tyrosine phosphatase STEP constrains amygdala-depe ndent memory formation and neuroplasticity. (PubMed id 22885232)1 Olausson P....Lombroso P.J. (2012)
    9. Involvement of PTPN5, the gene encoding the striatal-e nriched protein tyrosine phosphatase, in schizophrenia and cognition. (PubMed id 22555153)1 Pelov I....Kohn Y. (2012)
    10. Reduced levels of the tyrosine phosphatase STEP block I^ amyloid-mediated GluA1/GluA2 receptor internalization. (PubMed id 21883219)1 Zhang Y....Lombroso P.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84867 HGNC: 9657 AceView: PTPN5 Ensembl:ENSG00000110786 euGenes: HUgn84867
    ECgene: PTPN5 Kegg: 84867 H-InvDB: PTPN5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPN5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTPN5 gene:
    Search GeneIP for patents involving PTPN5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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