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PTPN4 Gene

protein-coding   GIFtS: 59
GCID: GC02P120612

Protein Tyrosine Phosphatase, Non-Receptor Type 4 (Megakaryocyte)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 4 (Megakaryocyte)1 2     PTPMEG12
Protein-Tyrosine Phosphatase MEG12 3     Megakaryocyte Phosphatase2
MEG2 3     Megakaryocyte Protein-Tyrosine Phosphatase2
PTPase-MEG12 3     Protein Tyrosine Phosphatase MEG12
EC 3.1.3.483 8     Tyrosine-Protein Phosphatase Non-Receptor Type 42
PTPMEG2     

External Ids:    HGNC: 96561   Entrez Gene: 57752   Ensembl: ENSG000000881797   OMIM: 1768785   UniProtKB: P290743   

Export aliases for PTPN4 gene to outside databases

Previous GC identifers: GC02P117722 GC02P118437 GC02P120424 GC02P120233 GC02P112841


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPN4 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal
domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to
interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling
downstream of the glutamate receptors through tyrosine dephosphorylation. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTPN4 Gene:
PTPN4 (protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)) is a protein-coding gene. GO annotations related to this gene include cytoskeletal protein binding and non-membrane spanning protein tyrosine phosphatase activity. An important paralog of this gene is EPB41L5.

UniProtKB/Swiss-Prot: PTN4_HUMAN, P29074
Function: May act at junctions between the membrane and the cytoskeleton

Gene Wiki entry for PTPN4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPN4 gene promoter:
         C/EBPbeta   Pax-5   MEF-2   Pax-2   MyoD   Pax-2a   MEF-2A   Pax-2b   Chx10   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN4 promoter sequence
   Search Chromatin IP Primers for PTPN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.2   Ensembl cytogenetic band:  2q14.2   HGNC cytogenetic band: 2q14.2

PTPN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P120612:  view genomic region     (about GC identifiers)

Start:
120,517,207 bp from pter      End:
120,741,394 bp from pter
Size:
224,188 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PTN4_HUMAN, P29074 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 4  
Size: 926 amino acids; 105911 Da
5 PDB 3D structures from and Proteopedia for PTPN4:
2CS5 (3D)        2I75 (3D)        2VPH (3D)        3NFK (3D)        3NFL (3D)    
Secondary accessions: B2RBV8 Q9UDA7

Explore the universe of human proteins at neXtProt for PTPN4: NX_P29074

Explore proteomics data for PTPN4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTPN4 (P29074) (see all 6)
     VVHCSAG  YPLDIVR  KCHQYWP  WPDHGVP 


    See PTPN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002821.1  
    ENSEMBL proteins: 
     ENSP00000263708   ENSP00000405763   ENSP00000438445   ENSP00000411364   ENSP00000395603  
     ENSP00000387457   ENSP00000394706   ENSP00000445841  

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    Cloud-Clone Corp. Proteins for PTPN4

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    Selected InterPro protein domains (see all 15):
     IPR019748 FERM_central
     IPR012151 Tyr_Pase_non-rcpt_typ-3/4
     IPR019750 Band_41_fam
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt

    Graphical View of Domain Structure for InterPro Entry P29074

    ProtoNet protein and cluster: P29074

    4 Blocks protein domains:
    IPB000242 Protein tyrosine phosphatase signature
    IPB000299 Band 4.1 domain
    IPB000798 ERM family signature
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: PTN4_HUMAN, P29074
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPN4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN4_HUMAN, P29074
    Function: May act at junctions between the membrane and the cytoskeleton
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0004726non-membrane spanning protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI16169070
    GO:0008092cytoskeletal protein binding IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
         
    Find genes that share ontologies with PTPN4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PTPN4:
     Decreased viability of wild-ty  Increased cell death in breast 

         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ptpn4):
     behavior/neurological  immune system  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with PTPN4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTPN4: Ptpn4tm1Tya Ptpn4tm1.1Oers

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTPN4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPN4
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    miRNA
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    miRTarBase miRNAs that target PTPN4:
    hsa-mir-93-5p (MIRT028116), hsa-mir-19b-3p (MIRT031282), hsa-mir-148a-3p (MIRT025984), hsa-mir-130b-3p (MIRT020328)

    Block miRNA regulation of human, mouse, rat PTPN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPN4 (see all 22):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-512-3p hsa-miR-93 hsa-miR-375 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidPTPN4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PTPN4

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    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for PTPN4 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTN4_HUMAN, P29074: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm,
    cytoskeleton (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    cytoskeleton2
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10940933
    GO:0005856cytoskeleton IEA--
    GO:0009898cytoplasmic side of plasma membrane IDA10940933
    GO:0019898extrinsic component of membrane ----

    Find genes that share ontologies with PTPN4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPN4 About    
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPN4
        Epithelial Adherens Junctions


        Pathway & Disease-focused RT2 Profiler PCR Array including PTPN4: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for PTPN4 (P290741, 2, 3 ENSP000002637084) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KAT5Q929931, 2, 3EBI-710431,EBI-399080 MINT-63638 I2D: score=6 
    ABL1P005192, 3, ENSP000003614234MINT-8110659 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111463 I2D: score=3 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8112171 I2D: score=3 STRING: ENSP00000274335
    EEF1GP266412, 3MINT-63635 I2D: score=5 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS1648233
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS1648233

    Find genes that share ontologies with PTPN4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPN4 (PTN4)

    2 HMDB Compounds for PTPN4    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PTPN4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AlendronateAcide Alendronique [INN-French] (see all 5)66376-36-1targetinhibitor9310349

    1 Novoseek inferred chemical compound relationship for PTPN4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 39.4 4 1557404 (1), 11054567 (1), 16619586 (1), 8253532 (1)



    Find genes that share compounds with PTPN4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTPN4 gene: 
    NM_002830.3  

    Unigene Cluster for PTPN4:

    Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
    Hs.469809  [show with all ESTs]
    Unigene Representative Sequence: NM_002830
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263708(uc002tmf.1) ENST00000460162 ENST00000420482 ENST00000460289
    ENST00000488279 ENST00000485247 ENST00000433888 ENST00000430976(uc010flj.1 uc010yyr.1)
    ENST00000488896 ENST00000431283 ENST00000469511 ENST00000441089 ENST00000544261

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PTPN4 (see all 22):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-512-3p hsa-miR-93 hsa-miR-375 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidPTPN4 3' UTR sequence
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    Addgene plasmids for PTPN4 
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      QuantiFast Probe-based Assays in human, mouse, rat PTPN4

    Additional mRNA sequence: 

    AK025546.1 AK301218.1 AK314836.1 BC010674.1 BC037838.1 BX648614.1 M68941.1 

    9 DOTS entries:

    DT.211389  DT.452802  DT.97839072  DT.99982978  DT.95164017  DT.91954489  DT.100803769  DT.99989013 
    DT.91692041 

    Selected AceView cDNA sequences (see all 74):

    AL705841 BM557364 BM702478 NM_002830 AA100449 BC010674 AA232644 BQ065150 
    AI870891 AA232769 BM909601 AW451177 AA307607 BX648614 CA312532 M68941 
    BQ331138 BG758829 CA432732 CF780863 AW005820 AU129566 BF917177 BM511048 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:              -                                                                                   -                 -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
    SP1:                                    
    SP2:                                    
    SP3:                                    


    ECgene alternative splicing isoforms for PTPN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTPN4 Expression
    About this image

    PTPN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469809
        Pathway & Disease-focused RT2 Profiler PCR Array including PTPN4: 
              Protein Phosphatases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTPN4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn41 , 5 protein tyrosine phosphatase, non-receptor type 41, 5 92.44(n)1
    94.71(a)1
      1 (52.39 cM)5
    192581  NM_019933.21  NP_064317.21 
     1196580445 
    chicken
    (Gallus gallus)
    Aves PTPN41 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 85.31(n)
    92.55(a)
      424234  XM_004942893.1  XP_004942950.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN46
    protein tyrosine phosphatase, non-receptor type 4 ...
    91(a)
    1 ↔ 1
    1(85288275-85365841)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.148152 Xenopus laevis transcribed sequence with moderate similarity more 76.37(n)    BQ734086.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi40g112 Transcribed sequence with weak similarity to protein more 70.23(n)    57066626 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ptpmeg1 , 3 protein tyrosine phosphatase3
    Ptpmeg1
    47(a)
    (best of 2)3
    48.48(n)1
    45.89(a)1
      61C13
    380591  NM_167831.31  NP_728523.21 
    worm
    (Caenorhabditis elegans)
    Secernentea ptp-11 , 3 protein tyrosine phosphatase (non
    receptor type) more3
    ptp-11
    58(a)
    (best of 5)3
    59.97(n)1
    58.13(a)1
      III(3662582-3683374)3
    131889831  NM_065332.31  NP_497733.11 


    ENSEMBL Gene Tree for PTPN4 (if available)
    TreeFam Gene Tree for PTPN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPN4 gene
    EPB41L52  EPB412  FRMD32  EPB41L12  PTPN32  EPB41L4B2  FARP12  FRMD52  
    FRMD72  EPB41L32  EPB41L4A2  FARP22  EPB41L22  
    Selected SIMAP similar genes for PTPN4 using alignment to 12 protein entries:     PTN4_HUMAN (see all proteins) (see all similar genes):
    EPB41L3    DKFZp313F1310    DKFZp686N0569    PTPN3    EPB41    EPB41L2
    FARP2    FARP1    EPB41L5    EPB41L1    EPB41L4A    EPB41L4B
    EZR    FRMD5    FRMD3    PTN2    PTPN14    PTPN13

    Find genes that share paralogs with PTPN4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PTPN4
    PGOHUM00000249539


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPN4 (see all 3887)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs665898371,2
    C--113007459(-) GATGT-/CTAA  
            
    CCACT
    1 -- int12Minor allele frequency- CTAA:0.25NA 4
    rs559462161,2
    C--113027583(+) AAAAA-/TTAAAA
            
    ATAAA
    1 -- int11Minor allele frequency- TTAAAA:0.00NA 2
    rs1886587091,2
    --120515308(+) TCAAGC/TGCAGG 1 -- us2k10--------
    rs745497911,2
    F--120515417(+) ATTTTA/GTAGAT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1150398521,2
    F--120515470(+) TAGTCT/CACACC 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1456062921,2
    --120515472(+) GTCTAC/TACCCC 1 -- us2k10--------
    rs1152778331,2
    F--120515486(+) TACTCC/TAGGGT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1398017761,2
    --120515550(+) CTCACA/TCCTGT 1 -- us2k10--------
    rs1811904751,2
    --120515589(+) GGAAGA/CTTGCT 1 -- us2k10--------
    rs1862503331,2
    C--120515592(+) AGATTA/GCTTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTPN4 (120517207 - 120741394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PTPN4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2893CNV Insertion18451855
    nsv874968CNV Loss21882294
    nsv834345CNV Gain17160897
    nsv874963CNV Gain21882294
    nsv874967CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTPN4
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176878    OMIM disorders: --


    Find genes that share disorders with PTPN4           About GenesLikeMe


    Export disorders for PTPN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPN4 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with PTPN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. (PubMed id 1648233)1, 2, 3, 9 Gu M.... Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Alendronate inhibition of protein-tyrosine-phosphatase-meg1. (PubMed id 9310349)7, 9 Opas E.E....Schmidt A. (Biochem. Pharmacol. 1997)
    4. Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG. (PubMed id 11054567)1, 9 Park K.W....Baik J. (Gene 2000)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. PTPN4 negatively regulates CrkI in human cell lines. (PubMed id 23666597)1 Zhou J....Huo K. (amp 2013)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions. (PubMed id 18614237)1 Young J.A....van Oers N.S. (Mol. Immunol. 2008)
    10. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5775 HGNC: 9656 AceView: PTPN4 Ensembl:ENSG00000088179 euGenes: HUgn5775
    ECgene: PTPN4 H-InvDB: PTPN4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPN4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPN4 gene:
    Search GeneIP for patents involving PTPN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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