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Aliases for PTPN4 Gene

Aliases for PTPN4 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 4 (Megakaryocyte) 2 3
  • Protein-Tyrosine Phosphatase MEG1 3 4
  • PTPase-MEG1 3 4
  • EC 3.1.3.48 4 64
  • MEG 3 4
  • Tyrosine-Protein Phosphatase Non-Receptor Type 4 3
  • Megakaryocyte Protein-Tyrosine Phosphatase 3
  • Protein Tyrosine Phosphatase MEG1 3
  • Megakaryocyte Phosphatase 3
  • PTPMEG1 3
  • PTPMEG 3

External Ids for PTPN4 Gene

Summaries for PTPN4 Gene

Entrez Gene Summary for PTPN4 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPN4 Gene

PTPN4 (Protein Tyrosine Phosphatase, Non-Receptor Type 4 (Megakaryocyte)) is a Protein Coding gene. Among its related pathways are PAK Pathway. GO annotations related to this gene include cytoskeletal protein binding and non-membrane spanning protein tyrosine phosphatase activity. An important paralog of this gene is FRMD3.

UniProtKB/Swiss-Prot for PTPN4 Gene

  • May act at junctions between the membrane and the cytoskeleton

Gene Wiki entry for PTPN4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN4 Gene

Genomics for PTPN4 Gene

Genomic Location for PTPN4 Gene

Start:
119,759,631 bp from pter
End:
119,984,899 bp from pter
Size:
225,269 bases
Orientation:
Plus strand

Genomic View for PTPN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN4 Gene

Regulatory Elements for PTPN4 Gene

Proteins for PTPN4 Gene

  • Protein details for PTPN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29074-PTN4_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 4
    Protein Accession:
    P29074
    Secondary Accessions:
    • B2RBV8
    • Q9UDA7

    Protein attributes for PTPN4 Gene

    Size:
    926 amino acids
    Molecular mass:
    105911 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPN4 Gene

neXtProt entry for PTPN4 Gene

Proteomics data for PTPN4 Gene at MOPED

Selected DME Specific Peptides for PTPN4 Gene

Post-translational modifications for PTPN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPN4 Gene

Domains for PTPN4 Gene

Gene Families for PTPN4 Gene

HGNC:
  • PTPN :Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

UniProtKB/Swiss-Prot:

PTN4_HUMAN
Domain:
  • Contains 1 FERM domain.:
    • P29074
  • Contains 1 PDZ (DHR) domain.:
    • P29074
  • Contains 1 tyrosine-protein phosphatase domain.:
    • P29074
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.:
    • P29074
genes like me logo Genes that share domains with PTPN4: view

Function for PTPN4 Gene

Molecular function for PTPN4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: May act at junctions between the membrane and the cytoskeleton

Enzyme Numbers (IUBMB) for PTPN4 Gene

Gene Ontology (GO) - Molecular Function for PTPN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity --
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 16169070
GO:0008092 cytoskeletal protein binding IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity --
genes like me logo Genes that share ontologies with PTPN4: view
genes like me logo Genes that share phenotypes with PTPN4: view

Animal Models for PTPN4 Gene

MGI Knock Outs for PTPN4:

miRNA for PTPN4 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for PTPN4 Gene

Localization for PTPN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN4 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPN4 Gene COMPARTMENTS Subcellular localization image for PTPN4 gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 2
nucleus 1

Gene Ontology (GO) - Cellular Components for PTPN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10940933
GO:0005856 cytoskeleton IEA --
GO:0009898 cytoplasmic side of plasma membrane IDA 10940933
GO:0019898 extrinsic component of membrane --
genes like me logo Genes that share ontologies with PTPN4: view

Pathways for PTPN4 Gene

SuperPathways for PTPN4 Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPN4: view

Pathways by source for PTPN4 Gene

1 Qiagen pathway for PTPN4 Gene

Gene Ontology (GO) - Biological Process for PTPN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 1648233
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 1648233
genes like me logo Genes that share ontologies with PTPN4: view

Compounds for PTPN4 Gene

(2) HMDB Compounds for PTPN4 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(1) Drugbank Compounds for PTPN4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alendronate
  • Acide Alendronique [INN-French]
66376-36-1 target inhibitor

(1) Novoseek inferred chemical compound relationships for PTPN4 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 39.4 4
genes like me logo Genes that share compounds with PTPN4: view

Transcripts for PTPN4 Gene

Unigene Clusters for PTPN4 Gene

Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - -
SP2:
SP3:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2:
SP3:

Relevant External Links for PTPN4 Gene

GeneLoc Exon Structure for
PTPN4
ECgene alternative splicing isoforms for
PTPN4

Expression for PTPN4 Gene

mRNA expression in normal human tissues for PTPN4 Gene

mRNA differential expression in normal tissues according to GTEx for PTPN4 Gene

This gene is overexpressed in Brain - Cerebellum (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTPN4 Gene

SOURCE GeneReport for Unigene cluster for PTPN4 Gene Hs.469809

genes like me logo Genes that share expressions with PTPN4: view

Orthologs for PTPN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPN4 36
  • 99.68 (n)
  • 99.68 (a)
PTPN4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPN4 36
  • 92.58 (n)
  • 96.65 (a)
PTPN4 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPN4 36
  • 95.39 (n)
  • 97.3 (a)
PTPN4 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpn4 36
  • 92.44 (n)
  • 94.71 (a)
Ptpn4 16
Ptpn4 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPN4 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 89 (a)
OneToMany
-- 37
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ptpn4 36
  • 92.19 (n)
  • 95.57 (a)
chicken
(Gallus gallus)
Aves PTPN4 36
  • 85.31 (n)
  • 92.55 (a)
PTPN4 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPN4 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14815 36
zebrafish
(Danio rerio)
Actinopterygii ptpn4a 36
  • 72.89 (n)
  • 81.12 (a)
ptpn4a 37
  • 80 (a)
OneToMany
ptpn4b 37
  • 72 (a)
OneToMany
wufi40g11 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007130 36
  • 49.77 (n)
  • 47.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ptpmeg 36
  • 48.48 (n)
  • 45.89 (a)
Ptpmeg 37
  • 41 (a)
OneToMany
Ptpmeg 38
  • 47 (a)
CG5022 38
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea ptp-1 36
  • 59.97 (n)
  • 58.13 (a)
ptp-1 37
  • 40 (a)
OneToMany
F25H5.7 38
  • 36 (a)
F36H12.10 38
  • 32 (a)
ptp-1 38
  • 58 (a)
F55F8.7 38
  • 36 (a)
C02B10.6 38
  • 32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11441 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToMany
Species with no ortholog for PTPN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPN4 Gene

ENSEMBL:
Gene Tree for PTPN4 (if available)
TreeFam:
Gene Tree for PTPN4 (if available)

Paralogs for PTPN4 Gene

Pseudogenes.org Pseudogenes for PTPN4 Gene

genes like me logo Genes that share paralogs with PTPN4: view

Variants for PTPN4 Gene

Sequence variations from dbSNP and Humsavar for PTPN4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs882390 -- 119,942,166(+) AATTG(C/T)GCAAT intron-variant
rs899764 -- 119,796,095(+) AGGGC(A/G)GGGGT intron-variant
rs899768 -- 119,812,975(+) tgcgt(A/G)agaaa intron-variant
rs949529 -- 119,859,969(+) TTCAT(A/C)AGCAC intron-variant
rs949530 -- 119,859,912(+) TACCA(C/T)GTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPN4 Gene

Variant ID Type Subtype PubMed ID
nsv874963 CNV Gain 21882294
nsv874967 CNV Gain 21882294
nsv874968 CNV Loss 21882294
nsv834345 CNV Gain 17160897
nsv2893 CNV Insertion 18451855

Relevant External Links for PTPN4 Gene

HapMap Linkage Disequilibrium report
PTPN4

Disorders for PTPN4 Gene

No disorders were found for PTPN4 Gene.

No data available for UniProtKB/Swiss-Prot for PTPN4 Gene

Publications for PTPN4 Gene

  1. Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. (PMID: 1648233) Gu M. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23
  2. Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG. (PMID: 11054567) Park K.W. … Baik J. (Gene 2000) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Alendronate inhibition of protein-tyrosine-phosphatase-meg1. (PMID: 9310349) Opas E.E. … Schmidt A. (Biochem. Pharmacol. 1997) 23 25
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for PTPN4 Gene

  • Addgene plasmids for PTPN4

Sources for PTPN4 Gene

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