Aliases for PTPN3 Gene
External Ids for PTPN3 Gene
Previous GeneCards Identifiers for PTPN3 Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
GeneCards Summary for PTPN3 Gene
PTPN3 (Protein Tyrosine Phosphatase, Non-Receptor Type 3) is a Protein Coding gene. Diseases associated with PTPN3 include Cholangiocarcinoma, Susceptibility To and Non-Functioning Pituitary Adenoma. Among its related pathways are TNFR1 Pathway and PAK Pathway. GO annotations related to this gene include phosphatase activity and cytoskeletal protein binding. An important paralog of this gene is PTPN4.
UniProtKB/Swiss-Prot for PTPN3 Gene
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.