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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PTPN3 Gene

protein-coding GIFtS: 62
GCID: GC09M112138

protein tyrosine phosphatase, non-receptor type 3

Explore 66 diseases affiliated with
PTPN3 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 3¹ ²		EC 3.1.3.48³ ⁸
PTPH1¹ ² ³		Cytoskeletal-Associated Protein Tyrosine Phosphatase²
Protein-Tyrosine Phosphatase H1² ³		Tyrosine-Protein Phosphatase Non-Receptor Type 3²
PTP-H1² ³

External Ids:	HGNC: 9655¹	Entrez Gene: 5774²	Ensembl: ENSG00000070159⁷	OMIM: 176877⁵	UniProtKB: P26045³

Export aliases for PTPN3 gene to outside databases

Previous GC identifers: GC09M102938 GC09M103872 GC09M105597 GC09M107520 GC09M109220 GC09M111177 GC09M081738

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPN3:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be

signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic

cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous

to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of

membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with,

and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different

isoforms have been found for this gene. (provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: PTN3_HUMAN, P26045

Function: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity

Gene Wiki entry for PTPN3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTPN3 gene promoter:
E2F-4 E2F-3a USF1 E2F-5 Nkx2-5 E2F-2 POU6F1 (c2) E2F E2F-1 USF-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for PTPN3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31 Ensembl cytogenetic band: 9q31.3 HGNC cytogenetic band: 9q31

PTPN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN3 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M112138: view genomic region (about GC identifiers)

Start:	112,137,974 bp from pter	End:	112,260,593 bp from pter
Size:	122,620 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PTN3_HUMAN, P26045 (See protein sequence)

Recommended Name: Tyrosine-protein phosphatase non-receptor type 3

Size: 913 amino acids; 103990 Da

Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton

1 PDB 3D structure from and Proteopedia for PTPN3:

2B49 (3D)

Secondary accessions: A0AUW9 E7EN99 E9PGU7

Alternative splicing: 3 isoforms: P26045-1 P26045-2 P26045-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPN3: NX_P26045

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P26045

4/5 DME Specific Peptides for PTPN3 (P26045) (see all 5)

YPLDIVR

KCHQYWP

WPDHGVP

YIATQGP

PTPN3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001138840.1 NP_001138841.1 NP_001138842.1 NP_001138843.1 NP_001138844.1 NP_002820.3

ENSEMBL proteins:

ENSP00000363667 ENSP00000378308 ENSP00000262539 ENSP00000416654 ENSP00000395384

ENSP00000378304

Human Recombinant Protein Products:

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	Uscn Proteins for PTPN3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	10940933
GO:0005856	cytoskeleton	IEA	--
GO:0009898	internal side of plasma membrane	IDA	10940933

PTPN3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PTPN3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTPN3 for domains About GeneDecksing

5/14 InterPro domains/families (see all 14):

IPR019748 FERM_central

IPR012151 Tyr_Pase_non-rcpt_typ-3/4

IPR019750 Band_41_fam

IPR016130 Tyr_Pase_AS

IPR000242 Tyr_Pase_rcpt/non-rcpt

Graphical View of Domain Structure for InterPro Entry P26045

ProtoNet protein and cluster: P26045

4 Blocks protein families:

IPB000242 Protein tyrosine phosphatase signature

IPB000299 Band 4.1 domain

IPB000798 ERM family signature

IPB001478 PDZ/DHR/GLGF domain

UniProtKB/Swiss-Prot: PTN3_HUMAN, P26045

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily

Similarity: Contains 1 FERM domain

Similarity: Contains 1 PDZ (DHR) domain

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PTN3_HUMAN, P26045

Function: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Genatlas biochemistry entry for PTPN3:

protein tyrosine phosphatase,non receptor type 3,(ERM) family member,responding and participating in reorganization of

membrane-cytoplasmic interactions

Enzyme Number (IUBMB): EC 3.1.3.48¹ ²

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN3
		8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN3 (see all 93):
		hsa-miR-1321 hsa-miR-15a hsa-miR-199a-3p hsa-miR-106a hsa-miR-1258 hsa-miR-1260b hsa-miR-128 hsa-miR-4267

		SwitchGear 3'UTR luciferase reporter plasmid: PTPN3 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN3

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001784	phosphotyrosine binding	IPI	10364224
GO:0004725	protein tyrosine phosphatase activity	IDA	19167335
GO:0004872	receptor activity	--	--
GO:0005515	protein binding	IPI	12207026
GO:0008092	cytoskeletal protein binding	IEA	--

PTPN3 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for PTPN3:

Decreased focal adhesion (FA)

Increased cell death in HCT116

Increased cell death in breast

Synthetic lethal with paclitax

Animal Models:
Mouse knock-out Ptpn3^tm1Pdk for PTPN3
5 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Ptpn3):

growth/size

immune system

no phenotypic analysis

normal

skeleton

PTPN3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

TWEAK Pathway

Apoptotic Pathways Triggered By HIV1

0.37

PAK Pathway

Epithelial Adherens Junctions

0.36

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTPN3 (see all 6)

	Activation of PKA through GPCR
	PKA Signaling
	Apoptotic Pathways Triggered By HIV1
	cAMP Pathway
	Activation of cAMP-Dependent PKA

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTPN3

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/17 Interacting proteins for PTPN3 (P26045^{1, 2, 3} ENSP00000262539⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GHR	P10912¹^,²^,³, ENSP00000230882⁴	EBI-1047946,EBI-286316 MINT-6797590 MINT-6797814 MINT-6797489 MINT-6797621 MINT-6797890 I2D: score=3 STRING: ENSP00000230882
SFN	P31947²^,³	MINT-3975189 I2D: score=2
YWHAZ	P63104²^,³	MINT-3317913 I2D: score=1
YWHAB	P31946²^,³, ENSP00000300161⁴	MINT-8005194 MINT-8005187 I2D: score=4 STRING: ENSP00000300161
ADAM17	P78536²^,³, ENSP00000309968⁴	MINT-58311 MINT-58317 I2D: score=3 STRING: ENSP00000309968

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006470	protein dephosphorylation	IDA	10364224
GO:0035335	peptidyl-tyrosine dephosphorylation	TAS	1648725
GO:0045930	negative regulation of mitotic cell cycle	IDA	10364224
GO:0051045	negative regulation of membrane protein ectodomain proteolysis	IMP	12207026

PTPN3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PTPN3 for compounds About GeneDecksing

EMD Millipore small molecules for PTPN3:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PTPN3

2 HMDB Compounds for PTPN3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10/93 Novoseek chemical compound relationships for PTPN3 gene (see all 93) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	92.5	1494	14983067 (6), 12941469 (6), 7907795 (5), 9275062 (4) (see all 99)
sodium orthovanadate	89.7	53	1655274 (1), 15004519 (1), 7673119 (1), 8941358 (1) (see all 53)
vanadate	88.5	84	9564854 (2), 7883973 (2), 9535775 (2), 1312177 (2) (see all 76)
phenylarsine oxide	86.4	51	9505351 (2), 8110195 (2), 1325458 (1), 10385133 (1) (see all 36)
phosphotyrosine	82.9	18	7692368 (2), 1316270 (1), 7498427 (1), 1648262 (1) (see all 17)
genistein	74	28	15935067 (1), 8941358 (1), 11329620 (1), 7744319 (1) (see all 26)
threonine	73.1	54	12769677 (3), 18073210 (2), 12673251 (1), 1330783 (1) (see all 48)
dephostatin	71.2	5	9381983 (1), 19707507 (1), 7572353 (1), 11012840 (1)
herbimycin a	71	8	15935067 (1), 8683142 (1), 9111028 (1), 9350436 (1) (see all 8)
bpv(phen)	70.8	2	12581886 (1), 18216177 (1)

Search CenterWatch for drugs/clinical trials and news about PTPN3 / PTN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PTPN3 gene (6 alternative transcripts):

NM_001145368.1 NM_001145369.1 NM_001145370.1 NM_001145371.1 NM_001145372.1 NM_002829.3

Unigene Cluster for PTPN3:

Protein tyrosine phosphatase, non-receptor type 3

Hs.436429 [show with all ESTs]

Unigene Representative Sequence: NM_001145369

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000374541 ENST00000497739 ENST00000394831(uc011lwd.1 uc011lwe.1 uc011lwf.1 uc010mtu.2 uc004bed.2 uc011lwg.1 uc011lwh.1 uc004bee.4)

ENST00000262539 ENST00000412145(uc004beb.2) ENST00000446349(uc004bec.2)

ENST00000394827

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		8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN3 (see all 93):
		hsa-miR-1321 hsa-miR-15a hsa-miR-199a-3p hsa-miR-106a hsa-miR-1258 hsa-miR-1260b hsa-miR-128 hsa-miR-4267

		SwitchGear 3'UTR luciferase reporter plasmid: PTPN3 3' UTR sequence

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Additional cDNA sequence:

AK096975.1 AK296265.1 AK296388.1 AK303608.1 AK304434.1 AK308349.1 AK316066.1 AK316118.1

BC033716.1 BC126117.1 BC143848.1 BX648253.1 BX648735.1 CR749204.1 M64572.1 NR_026918.1

S39392.1

12 DOTS entries:

DT.101979387 DT.92016697 DT.75173572 DT.91650494 DT.95272145 DT.92423622 DT.100739132 DT.92423621

DT.91728395 DT.95272147 DT.121200338 DT.121200318

24/180 AceView cDNA sequences (see all 180):

BU078992 AU142086 BC033716 BM129571 AW614641 BF446162 BX099807 NM_002829

BG767944 BM988026 BX648253 BF437384 BM982508 BF475578 Z42061 AW517822

CK819572 AK096975 BU624870 AI040327 F07320 CB851661 BQ016336 AI078025

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN3 (see all 14) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^
SP1:											-		-		-		-						-						-														-								-
SP2:											-		-		-		-						-						-														-								-
SP3:																							-						-														-								-
SP4:																							-						-														-		-						-
SP5:											-		-		-		-

ExUns:	17a	·	17b	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^	27a	·	27b	·	27c	·	27d	^	28a	·	28b	^	29a	·	29b	^	30a	·	30b	·	30c
SP1:													-		-								-						-
SP2:													-		-								-
SP3:													-		-								-						-
SP4:													-		-								-						-
SP5:

ECgene alternative splicing isoforms for PTPN3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PTPN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

PTPN3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Metanephros

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PTPN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTPN3

SOURCE GeneReport for Unigene cluster: Hs.436429

SABiosciences Expression via Pathway-Focused PCR Array including PTPN3:

Protein Phosphatases in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PTPN3 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PTPN3¹	protein tyrosine phosphatase, non-receptor type 3	75.48(n) 78.49(a)		420963 XM_419047.3 XP_419047.3
lizard (Anolis carolinensis)	Reptilia	PTPN3⁶	--	75(a)	1 ↔ 1	6(57133099-57198909)
zebrafish (Danio rerio)	Actinopterygii	ptpn3¹	protein tyrosine phosphatase, non-receptor type 3	62.06(n) 59.54(a)		407635 XM_682838.5 XP_687930.4
fruit fly (Drosophila melanogaster)	Insecta	Ptpmeg³	protein tyrosine phosphatase	45(a)		61C1 --
worm (Caenorhabditis elegans)	Secernentea	ptp-1³	protein tyrosine phosphatase (non receptor type) more	51(a) (best of 8)		III(3662582-3683374) --

ENSEMBL Gene Tree for PTPN3 (if available)
TreeFam Gene Tree for PTPN3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PTPN3 gene

PTPN1² PTPN20C² FRMPD2² PTPN4² PTPN13² PTPN9² PTPN14² PTPN21²

PTPN20B² PTPN2² PTPN20A²

18/35 SIMAP similar genes for PTPN3 using alignment to 4 protein entries: PTN3_HUMAN (see all proteins) (see all similar genes):

DKFZp686N0569 PTPN4 EPB41L4A DKFZp781C1038 RDX BPTP-3

EPB41L1 PTPN2 PTPRH DKFZp566K0524 PTPN20A PTPN20B

PTPRK PTPRM PTPRQ PTPRA PTPRD PTPRN2

PTPN3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193920798^1,2	C,	unknown	112199206(-)	`CATAGC/TGCGGA`	8	A V	mis¹		0	--	--	--	--
rs140320951^1,2		--	112137510(+)	`CCCACA/GTCAAG`	7	--	ds500¹ int¹		0	--	--	--	--
rs115542974^1,2	F,	--	112137527(+)	`GCCAGG/AGGGAG`	7	--	ds500¹ int¹		1		WA	118
rs77986534^1,2	C,F,	--	112137528(+)	`CCAGGG/TGGAGA`	7	--	ds500¹ int¹		1		EA	120
rs117890457^1,2		--	112137554(+)	`GGAGGT/GTTCCC`	7	--	ds500¹ int¹		1		NA	120
rs145077948^1,2		--	112137557(+)	`GGTTTC/TCCCCA`	7	--	ds500¹ int¹		0	--	--	--	--
rs10979848^1,2		--	112137560(+)	`ttcccC/Tcatac`	7	--	ds500¹ int¹		0	--	--	--	--
rs190440790^1,2		--	112137564(+)	`CCCATA/GCTGTT`	7	--	ds500¹ int¹		0	--	--	--	--
rs182221632^1,2		--	112137573(+)	`TTCTCA/GTGGTG`	7	--	ds500¹ int¹		0	--	--	--	--
rs187176532^1,2		--	112137600(+)	`AGATCA/GGATGG`	7	--	ds500¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PTPN3 (112137974 - 112260593 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PTPN3
2 CNVs: 3778 33148

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PTPN3 for disorders           About GeneDecksing

OMIM gene information: 176877    OMIM disorders: --

20/66 diseases for PTPN3 (see all 66):    About MalaCards

bannayan-riley-ruvalcaba syndrome hypersensitivity reaction type ii disease cleft lip/palate ruvalcaba syndrome

functioning pituitary adenoma cleft lip severe congenital neutropenia pituitary adenoma

juvenile myelomonocytic leukemia type 1 diabetes mellitus diabetes mellitus insulin resistance

autonomic neuropathy scott syndrome acute promyelocytic leukemia noonan syndrome

brain injury gestational diabetes myelomonocytic leukemia neutropenia

3 diseases from the University of Copenhagen DISEASES database for PTPN3:

Diabetes mellitus Noonan syndrome Hypersensitivity reaction type II disease

10/32 Novoseek disease relationships for PTPN3 gene (see all 32) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
diabetes autoimmune	50.7	1	12021124 (1)
autoimmunity	45.6	3	20204370 (1), 8805677 (1)
diabetes mellitus insulin-dependent	33.4	2	9670839 (1), 20088380 (1)
ketosis	22.8	1	15059369 (1)
ketoacidosis	20.4	1	15059369 (1)
tumors	8.31	12	7548619 (1), 14676845 (1), 15155950 (1), 1347042 (1) (see all 12)
autoimmune diseases	8.06	2	15759012 (1), 19768773 (1)
virus infection	3.93	1	18988535 (1)
hepatocellular carcinoma	3.45	1	7874267 (1)
carcinoma lewis lung	2.5	1	9030244 (1)

Human Genome Epidemiology (HuGE) Navigator: PTPN3 (3 documents)

Export disorders for PTPN3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PTPN3 gene, integrated from 9 sources (see all 644):
(articles sorted by number of sources associating them with PTPN3)

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Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin. (PubMed id 1648725)^{1, 2, 3, 9} Yang Q. and Tonks N.K. (1991)
Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma. (PubMed id 7874267)^{1, 2, 9} Ikuta S....Yachi A. (1994)
Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)^{1, 2} Barr A.J.... Knapp S. (2009)
cDNA cloning of new protein tyrosine phosphatases in the human colon. (PubMed id 1626183)^{1, 2} Arimura Y.... Yachi A. (1992)
Suppression of hepatitis B viral gene expression by protein-tyrosine phosphatase PTPN3. (PubMed id 17588219)^{1, 9} Hsu E.C....Ting L.P. (2007)
Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein. (PubMed id 9341175)^{1, 9} Zhang S.H....Tonks N.K. (1997)
Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins. (PubMed id 8253532)^{1, 9} Itoh F....Yachi A. (1993)
Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins. (PubMed id 17166906)^{1, 9} Jing M....Vande Pol S.B. (2007)
Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. (PubMed id 17947517)^{1, 9} Topffer S....Steger G. (2007)
PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit. (PubMed id 14672952)^{1, 9} Sozio M.S....van Oers N.S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5774	HGNC: 9655	AceView: PTPN3	Ensembl:ENSG00000070159	euGenes: HUgn5774
ECgene: PTPN3	H-InvDB: PTPN3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PTPN3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PTPN3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PTPN3 gene
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Patent Information for PTPN3 gene:
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protein tyrosine phosphatase, non-receptor type 3

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protein tyrosine phosphatase, non-receptor type 3

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