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Aliases for PTPN3 Gene

Aliases for PTPN3 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 3 2 3 5
  • Protein-Tyrosine Phosphatase H1 3 4
  • EC 4 63
  • PTP-H1 3 4
  • PTPH1 3 4
  • Cytoskeletal-Associated Protein Tyrosine Phosphatase 3

External Ids for PTPN3 Gene

Previous GeneCards Identifiers for PTPN3 Gene

  • GC09M102938
  • GC09M103872
  • GC09M105597
  • GC09M107520
  • GC09M109220
  • GC09M111177
  • GC09M112138
  • GC09M081738

Summaries for PTPN3 Gene

Entrez Gene Summary for PTPN3 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

GeneCards Summary for PTPN3 Gene

PTPN3 (Protein Tyrosine Phosphatase, Non-Receptor Type 3) is a Protein Coding gene. Diseases associated with PTPN3 include Cholangiocarcinoma and Non-Functioning Pituitary Adenoma. Among its related pathways are TWEAK Pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include phosphatase activity and cytoskeletal protein binding. An important paralog of this gene is FRMD3.

UniProtKB/Swiss-Prot for PTPN3 Gene

  • May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Gene Wiki entry for PTPN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN3 Gene

Genomics for PTPN3 Gene

Regulatory Elements for PTPN3 Gene

Enhancers for PTPN3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTPN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPN3 Gene

109,375,466 bp from pter
109,538,353 bp from pter
162,888 bases
Minus strand

Genomic View for PTPN3 Gene

Genes around PTPN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN3 Gene

Proteins for PTPN3 Gene

  • Protein details for PTPN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 3
    Protein Accession:
    Secondary Accessions:
    • A0AUW9
    • E7EN99
    • E9PGU7

    Protein attributes for PTPN3 Gene

    913 amino acids
    Molecular mass:
    103990 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPN3 Gene

    Alternative splice isoforms for PTPN3 Gene


neXtProt entry for PTPN3 Gene

Proteomics data for PTPN3 Gene at MOPED

Selected DME Specific Peptides for PTPN3 Gene

Post-translational modifications for PTPN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for PTPH1
  • Abcam antibodies for PTPN3

Domains & Families for PTPN3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FERM domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
  • Contains 1 FERM domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with PTPN3: view

Function for PTPN3 Gene

Molecular function for PTPN3 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,non receptor type 3,(ERM) family member,responding and participating in reorganization of membrane-cytoplasmic interactions
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Enzyme Numbers (IUBMB) for PTPN3 Gene

Gene Ontology (GO) - Molecular Function for PTPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 10364224
genes like me logo Genes that share ontologies with PTPN3: view
genes like me logo Genes that share phenotypes with PTPN3: view

Human Phenotype Ontology for PTPN3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPN3 Gene

MGI Knock Outs for PTPN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPN3

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PTPN3 Gene

Localization for PTPN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN3 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for PTPN3 Gene COMPARTMENTS Subcellular localization image for PTPN3 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
nucleus 3
endoplasmic reticulum 2
extracellular 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for PTPN3 Gene

Pathways & Interactions for PTPN3 Gene

genes like me logo Genes that share pathways with PTPN3: view

SIGNOR curated interactions for PTPN3 Gene

Other effect:

Gene Ontology (GO) - Biological Process for PTPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,IDA 10364224
GO:0098902 regulation of membrane depolarization during action potential IDA 16930557
genes like me logo Genes that share ontologies with PTPN3: view

Drugs & Compounds for PTPN3 Gene

(47) Drugs for PTPN3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(49) Additional Compounds for PTPN3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with PTPN3: view

Transcripts for PTPN3 Gene

Unigene Clusters for PTPN3 Gene

Protein tyrosine phosphatase, non-receptor type 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP9: -

ExUns: 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b · 30c
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP9: - - - - - - - - - - - - -
SP12: -

Relevant External Links for PTPN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPN3 Gene

mRNA expression in normal human tissues for PTPN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPN3 Gene

This gene is overexpressed in Muscle - Skeletal (x9.4), Liver (x4.9), and Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for PTPN3 Gene

This gene is overexpressed in Placenta (52.9) and Liver (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN3 Gene

SOURCE GeneReport for Unigene cluster for PTPN3 Gene Hs.436429

genes like me logo Genes that share expression patterns with PTPN3: view

Protein tissue co-expression partners for PTPN3 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PTPN3 Gene

Orthologs for PTPN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PTPN3 35
  • 90.72 (n)
  • 94.3 (a)
PTPN3 36
  • 94 (a)
(Canis familiaris)
Mammalia PTPN3 35
  • 91.68 (n)
  • 94.19 (a)
PTPN3 36
  • 94 (a)
(Mus musculus)
Mammalia Ptpn3 35
  • 87.22 (n)
  • 92 (a)
Ptpn3 16
Ptpn3 36
  • 92 (a)
(Pan troglodytes)
Mammalia PTPN3 35
  • 99.53 (n)
  • 99.45 (a)
PTPN3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ptpn3 35
  • 87.48 (n)
  • 91.79 (a)
(Monodelphis domestica)
Mammalia PTPN3 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia PTPN3 36
  • 82 (a)
(Gallus gallus)
Aves PTPN3 35
  • 75.56 (n)
  • 78.81 (a)
PTPN3 36
  • 74 (a)
(Anolis carolinensis)
Reptilia PTPN3 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn3 35
  • 69.26 (n)
  • 72.7 (a)
(Danio rerio)
Actinopterygii ptpn3 35
  • 61.96 (n)
  • 59.11 (a)
ptpn3 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ptpmeg 37
  • 45 (a)
Ptpmeg 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea C02B10.6 37
  • 33 (a)
F25H5.7 37
  • 35 (a)
F36H1.3 37
  • 37 (a)
F36H12.10 37
  • 33 (a)
F55F8.7 37
  • 35 (a)
K07F5.8 37
  • 35 (a)
ptp-1 37
  • 51 (a)
T22C1.8 37
  • 35 (a)
ptp-1 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for PTPN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN3 Gene

Gene Tree for PTPN3 (if available)
Gene Tree for PTPN3 (if available)

Paralogs for PTPN3 Gene

genes like me logo Genes that share paralogs with PTPN3: view

Variants for PTPN3 Gene

Sequence variations from dbSNP and Humsavar for PTPN3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs35285139 - 109,457,309(+) GGAGT(C/T)GTCAT reference, missense, utr-variant-5-prime
rs3793524 - 109,457,194(+) GATGG(C/G)TTTGC reference, missense, utr-variant-5-prime
rs10979858 - 109,420,512(+) TTCCG(C/T)TTCCG reference, missense
rs7859962 - 109,404,586(+) GACTT(C/G/T)AAGTC nc-transcript-variant, reference, missense
rs10116806 - 109,383,518(+) GACGT(C/T)GGGGG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PTPN3 Gene

Variant ID Type Subtype PubMed ID
nsv831685 CNV Gain 17160897
dgv2410e1 CNV Complex 17122850
nsv8557 CNV Loss 18304495

Variation tolerance for PTPN3 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.57; 93.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPN3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN3 Gene

Disorders for PTPN3 Gene

MalaCards: The human disease database

(9) MalaCards diseases for PTPN3 Gene - From: GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • bile duct carcinoma
non-functioning pituitary adenoma
  • nfpa
diabetes mellitus, insulin-dependent
  • diabetes, type 1
functioning pituitary adenoma
  • secretory adenoma of the pituitary gland
scott syndrome
  • platelet factor x receptor deficiency
- elite association - COSMIC cancer census association via MalaCards
Search PTPN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPN3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PTPN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPN3 Gene

Publications for PTPN3 Gene

  1. Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin. (PMID: 1648725) Yang Q. … Tonks N.K. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23 67
  2. Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins. (PMID: 17166906) Jing M. … Vande Pol S.B. (J. Virol. 2007) 3 23
  3. Suppression of hepatitis B viral gene expression by protein-tyrosine phosphatase PTPN3. (PMID: 17588219) Hsu E.C. … Ting L.P. (J. Biomed. Sci. 2007) 3 23
  4. Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. (PMID: 17947517) TAPpffer S. … Steger G. (J. Gen. Virol. 2007) 3 23
  5. Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein. (PMID: 9341175) Zhang S.H. … Tonks N.K. (J. Biol. Chem. 1997) 3 23

Products for PTPN3 Gene

Sources for PTPN3 Gene