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Aliases for PTPN3 Gene

Aliases for PTPN3 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 3 2 3
  • PTPH1 3 4 6
  • Protein-Tyrosine Phosphatase H1 3 4
  • EC 3.1.3.48 4 63
  • PTP-H1 3 4
  • Cytoskeletal-Associated Protein Tyrosine Phosphatase 3
  • Tyrosine-Protein Phosphatase Non-Receptor Type 3 3

External Ids for PTPN3 Gene

Previous GeneCards Identifiers for PTPN3 Gene

  • GC09M102938
  • GC09M103872
  • GC09M105597
  • GC09M107520
  • GC09M109220
  • GC09M111177
  • GC09M112138
  • GC09M081738

Summaries for PTPN3 Gene

Entrez Gene Summary for PTPN3 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

GeneCards Summary for PTPN3 Gene

PTPN3 (Protein Tyrosine Phosphatase, Non-Receptor Type 3) is a Protein Coding gene. Diseases associated with PTPN3 include cholangiocarcinoma and bannayan-riley-ruvalcaba syndrome. Among its related pathways are PAK Pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein tyrosine phosphatase activity and ATPase binding. An important paralog of this gene is FRMD3.

UniProtKB/Swiss-Prot for PTPN3 Gene

  • May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity

Gene Wiki entry for PTPN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN3 Gene

Genomics for PTPN3 Gene

Regulatory Elements for PTPN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPN3 Gene

Start:
109,375,466 bp from pter
End:
109,498,320 bp from pter
Size:
122,855 bases
Orientation:
Minus strand

Genomic View for PTPN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN3 Gene

Proteins for PTPN3 Gene

  • Protein details for PTPN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26045-PTN3_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 3
    Protein Accession:
    P26045
    Secondary Accessions:
    • A0AUW9
    • E7EN99
    • E9PGU7

    Protein attributes for PTPN3 Gene

    Size:
    913 amino acids
    Molecular mass:
    103990 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPN3 Gene

    Alternative splice isoforms for PTPN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPN3 Gene

Proteomics data for PTPN3 Gene at MOPED

Selected DME Specific Peptides for PTPN3 Gene

Post-translational modifications for PTPN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for PTPN3 Gene

Gene Families for PTPN3 Gene

HGNC:
  • PTPN :Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

Graphical View of Domain Structure for InterPro Entry

P26045

UniProtKB/Swiss-Prot:

PTN3_HUMAN :
  • P26045
Domain:
  • Contains 1 FERM domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with PTPN3: view

Function for PTPN3 Gene

Molecular function for PTPN3 Gene

GENATLAS Biochemistry: protein tyrosine phosphatase,non receptor type 3,(ERM) family member,responding and participating in reorganization of membrane-cytoplasmic interactions
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity

Enzyme Numbers (IUBMB) for PTPN3 Gene

Gene Ontology (GO) - Molecular Function for PTPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine binding IPI 10364224
GO:0004725 protein tyrosine phosphatase activity IDA 19167335
GO:0005515 protein binding IPI 10364224
GO:0008092 cytoskeletal protein binding IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity --
genes like me logo Genes that share ontologies with PTPN3: view
genes like me logo Genes that share phenotypes with PTPN3: view

Animal Models for PTPN3 Gene

MGI Knock Outs for PTPN3:

Animal Model Products

CRISPR Products

miRNA for PTPN3 Gene

miRTarBase miRNAs that target PTPN3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PTPN3 Gene

Localization for PTPN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN3 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPN3 Gene COMPARTMENTS Subcellular localization image for PTPN3 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
extracellular 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PTPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10940933
GO:0005856 cytoskeleton IEA --
GO:0009898 cytoplasmic side of plasma membrane IDA 10940933
genes like me logo Genes that share ontologies with PTPN3: view

Pathways for PTPN3 Gene

genes like me logo Genes that share pathways with PTPN3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IDA 10364224
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 1648725
GO:0045930 negative regulation of mitotic cell cycle IDA 10364224
GO:0051045 negative regulation of membrane protein ectodomain proteolysis IMP 12207026
genes like me logo Genes that share ontologies with PTPN3: view

Compounds for PTPN3 Gene

(2) HMDB Compounds for PTPN3 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(93) Novoseek inferred chemical compound relationships for PTPN3 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 92.5 258
sodium orthovanadate 89.7 53
vanadate 88.5 80
phenylarsine oxide 86.4 38
phosphotyrosine 82.9 18
genes like me logo Genes that share compounds with PTPN3: view

Transcripts for PTPN3 Gene

Unigene Clusters for PTPN3 Gene

Protein tyrosine phosphatase, non-receptor type 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b · 30c
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9: - - - - - - - - - - - - -
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for PTPN3 Gene

GeneLoc Exon Structure for
PTPN3
ECgene alternative splicing isoforms for
PTPN3

Expression for PTPN3 Gene

mRNA expression in normal human tissues for PTPN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPN3 Gene

This gene is overexpressed in Muscle - Skeletal (9.4), Liver (4.9), and Heart - Left Ventricle (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN3 Gene

SOURCE GeneReport for Unigene cluster for PTPN3 Gene Hs.436429

genes like me logo Genes that share expressions with PTPN3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PTPN3 Gene

Orthologs for PTPN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPN3 35
  • 99.53 (n)
  • 99.45 (a)
PTPN3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPN3 35
  • 90.72 (n)
  • 94.3 (a)
PTPN3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPN3 35
  • 91.68 (n)
  • 94.19 (a)
PTPN3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpn3 35
  • 87.22 (n)
  • 92 (a)
Ptpn3 16
Ptpn3 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPN3 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPN3 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpn3 35
  • 87.48 (n)
  • 91.79 (a)
chicken
(Gallus gallus)
Aves PTPN3 35
  • 75.56 (n)
  • 78.81 (a)
PTPN3 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPN3 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn3 35
  • 69.26 (n)
  • 72.7 (a)
zebrafish
(Danio rerio)
Actinopterygii ptpn3 35
  • 61.96 (n)
  • 59.11 (a)
ptpn3 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ptpmeg 36
  • 35 (a)
OneToMany
Ptpmeg 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea ptp-1 36
  • 35 (a)
OneToMany
F25H5.7 37
  • 35 (a)
K07F5.8 37
  • 35 (a)
F36H12.10 37
  • 33 (a)
T22C1.8 37
  • 35 (a)
ptp-1 37
  • 51 (a)
F36H1.3 37
  • 37 (a)
F55F8.7 37
  • 35 (a)
C02B10.6 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for PTPN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN3 Gene

ENSEMBL:
Gene Tree for PTPN3 (if available)
TreeFam:
Gene Tree for PTPN3 (if available)

Paralogs for PTPN3 Gene

genes like me logo Genes that share paralogs with PTPN3: view

Variants for PTPN3 Gene

Sequence variations from dbSNP and Humsavar for PTPN3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs881723 -- 109,446,248(-) CTGGG(G/T)TGCTG intron-variant
rs881724 -- 109,446,167(-) CCCAC(C/T)CTTCA intron-variant
rs944358 -- 109,487,414(-) GACTG(C/T)CCTTT intron-variant
rs944359 -- 109,487,352(-) TTTGC(A/G)GCCAG intron-variant
rs947481 -- 109,411,389(+) CCACT(C/T)CCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPN3 Gene

Variant ID Type Subtype PubMed ID
nsv831685 CNV Gain 17160897
dgv2410e1 CNV Complex 17122850
nsv8557 CNV Loss 18304495

Relevant External Links for PTPN3 Gene

HapMap Linkage Disequilibrium report
PTPN3
Human Gene Mutation Database (HGMD)
PTPN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN3 Gene

Disorders for PTPN3 Gene

(3) University of Copenhagen DISEASES for PTPN3 Gene

(32) Novoseek inferred disease relationships for PTPN3 Gene

Disease -log(P) Hits PubMed IDs
diabetes autoimmune 50.7 1
autoimmunity 45.6 2
diabetes mellitus insulin-dependent 33.4 2
ketosis 22.8 1
ketoacidosis 20.4 1

Relevant External Links for PTPN3

Genetic Association Database (GAD)
PTPN3
Human Genome Epidemiology (HuGE) Navigator
PTPN3
genes like me logo Genes that share disorders with PTPN3: view

No data available for UniProtKB/Swiss-Prot for PTPN3 Gene

Publications for PTPN3 Gene

  1. Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin. (PMID: 1648725) Yang Q. … Tonks N.K. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23
  2. Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma. (PMID: 7874267) Ikuta S. … Yachi A. (J. Gastroenterol. 1994) 3 4 23
  3. Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins. (PMID: 17166906) Jing M. … Vande Pol S.B. (J. Virol. 2007) 3 23
  4. Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. (PMID: 17947517) TAPpffer S. … Steger G. (J. Gen. Virol. 2007) 3 23
  5. Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins. (PMID: 8253532) Itoh F. … Yachi A. (Int. J. Cancer 1993) 3 23

Products for PTPN3 Gene

Sources for PTPN3 Gene

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