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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPN3 Gene

protein-coding   GIFtS: 65
GCID: GC09M112138

Protein Tyrosine Phosphatase, Non-Receptor Type 3

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 31 2     EC 3.1.3.483 8
Protein-Tyrosine Phosphatase H12 3     Cytoskeletal-Associated Protein Tyrosine Phosphatase2
PTP-H12 3     Tyrosine-Protein Phosphatase Non-Receptor Type 32
PTPH12 3     

External Ids:    HGNC: 96551   Entrez Gene: 57742   Ensembl: ENSG000000701597   OMIM: 1768775   UniProtKB: P260453   

Export aliases for PTPN3 gene to outside databases

Previous GC identifers: GC09M102938 GC09M103872 GC09M105597 GC09M107520 GC09M109220 GC09M111177 GC09M081738


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPN3 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal
domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator
involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was
also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Feb 2009)

GeneCards Summary for PTPN3 Gene: 
PTPN3 (protein tyrosine phosphatase, non-receptor type 3) is a protein-coding gene. Diseases associated with PTPN3 include bannayan-riley-ruvalcaba syndrome, and ruvalcaba syndrome, and among its related super-pathways are Activation of cAMP-Dependent PKA and HIV-1 Nef- Negative effector of Fas and TNF-alpha. GO annotations related to this gene include protein tyrosine phosphatase activity and ATPase binding. An important paralog of this gene is EPB41L5.

UniProtKB/Swiss-Prot: PTN3_HUMAN, P26045
Function: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity

Gene Wiki entry for PTPN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPN3 gene promoter:
         E2F-4   E2F-3a   USF1   E2F-5   Nkx2-5   E2F-2   POU6F1 (c2)   E2F   E2F-1   USF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PTPN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31   Ensembl cytogenetic band:  9q31.3   HGNC cytogenetic band: 9q31

PTPN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M112138:  view genomic region     (about GC identifiers)

Start:
112,137,746 bp from pter      End:
112,260,593 bp from pter
Size:
122,848 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTN3_HUMAN, P26045 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 3  
Size: 913 amino acids; 103990 Da
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton
1 PDB 3D structure from and Proteopedia for PTPN3:
2B49 (3D)    
Secondary accessions: A0AUW9 E7EN99 E9PGU7
Alternative splicing: 3 isoforms:  P26045-1   P26045-2   P26045-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPN3: NX_P26045

Explore proteomics data for PTPN3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26045

  • 4/5 DME Specific Peptides for PTPN3 (P26045) (see all 5)
     YPLDIVR  KCHQYWP  WPDHGVP  YIATQGP 

    PTPN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTPN3 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001138840.1  NP_001138841.1  NP_001138842.1  NP_001138843.1  NP_001138844.1  NP_002820.3  

    ENSEMBL proteins: 
     ENSP00000363667   ENSP00000262539   ENSP00000416654   ENSP00000395384   ENSP00000378304  

    Human Recombinant Protein Products for PTPN3: 
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    OriGene Protein Over-expression Lysate for PTPN3
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    Novus Biologicals PTPN3 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTPN3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10940933
    GO:0005856cytoskeleton IEA--
    GO:0009898internal side of plasma membrane IDA10940933

    PTPN3 for ontologies           About GeneDecksing



    PTPN3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    5/14 InterPro protein domains (see all 14):
     IPR019748 FERM_central
     IPR012151 Tyr_Pase_non-rcpt_typ-3/4
     IPR019750 Band_41_fam
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt

    Graphical View of Domain Structure for InterPro Entry P26045

    ProtoNet protein and cluster: P26045

    4 Blocks protein domains:
    IPB000242 Protein tyrosine phosphatase signature
    IPB000299 Band 4.1 domain
    IPB000798 ERM family signature
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: PTN3_HUMAN, P26045
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    PTPN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN3_HUMAN, P26045
    Function: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN3:
    protein tyrosine phosphatase,non receptor type 3,(ERM) family member,responding and participating in
    reorganization of membrane-cytoplasmic interactions

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IPI10364224
    GO:0004725protein tyrosine phosphatase activity IDA19167335
    GO:0005515protein binding IPI12207026
    GO:0008092cytoskeletal protein binding IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
         
    PTPN3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PTPN3:
     Decreased focal adhesion (FA)   Increased cell death in HCT116  Increased cell death in breast  Synthetic lethal with paclitax 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ptpn3):
     growth/size  immune system  no phenotypic analysis  normal  skeleton 

    PTPN3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptpn3tm1Pdk for PTPN3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTPN3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTPN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPN3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPN3 

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    SwitchGear 3'UTR luciferase reporter plasmidPTPN3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTPN3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2TWEAK Pathway
    Apoptotic Pathways Triggered By HIV10.42
    3PAK Pathway
    Epithelial Adherens Junctions0.36

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTPN3 (see all 6)
        Activation of PKA through GPCR
    PKA Signaling
    Apoptotic Pathways Triggered By HIV1
    cAMP Pathway
    Activation of cAMP-Dependent PKA



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/17 Interacting proteins for PTPN3 (P260451, 2, 3 ENSP000002625394) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GHRP109121, 2, 3, ENSP000002308824EBI-1047946,EBI-286316 MINT-6797590 MINT-6797814 MINT-6797489 MINT-6797621 MINT-6797890 I2D: score=3 STRING: ENSP00000230882
    SFNP319472, 3MINT-3975189 I2D: score=2 
    YWHAZP631042, 3MINT-3317913 I2D: score=1 
    YWHABP319462, 3, ENSP000003001614MINT-8005194 MINT-8005187 I2D: score=4 STRING: ENSP00000300161
    ADAM17P785362, 3, ENSP000003099684MINT-58311 MINT-58317 I2D: score=3 STRING: ENSP00000309968
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IDA10364224
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS1648725
    GO:0045930negative regulation of mitotic cell cycle IDA10364224
    GO:0051045negative regulation of membrane protein ectodomain proteolysis IMP12207026

    PTPN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTPN3 for compounds           About GeneDecksing

    EMD Millipore small molecules for PTPN3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPN3 (PTN3)

    2 HMDB Compounds for PTPN3    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/93 Novoseek inferred chemical compound relationships for PTPN3 gene (see all 93)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 92.5 1494 14983067 (6), 12941469 (6), 7907795 (5), 9275062 (4) (see all 99)
    sodium orthovanadate 89.7 53 1655274 (1), 15004519 (1), 7673119 (1), 8941358 (1) (see all 53)
    vanadate 88.5 84 9564854 (2), 7883973 (2), 9535775 (2), 1312177 (2) (see all 76)
    phenylarsine oxide 86.4 51 9505351 (2), 8110195 (2), 1325458 (1), 10385133 (1) (see all 36)
    phosphotyrosine 82.9 18 7692368 (2), 1316270 (1), 7498427 (1), 1648262 (1) (see all 17)
    genistein 74 28 15935067 (1), 8941358 (1), 11329620 (1), 7744319 (1) (see all 26)
    threonine 73.1 54 12769677 (3), 18073210 (2), 12673251 (1), 1330783 (1) (see all 48)
    dephostatin 71.2 5 9381983 (1), 19707507 (1), 7572353 (1), 11012840 (1)
    herbimycin a 71 8 15935067 (1), 8683142 (1), 9111028 (1), 9350436 (1) (see all 8)
    bpv(phen) 70.8 2 12581886 (1), 18216177 (1)

    Search CenterWatch for drugs/clinical trials and news about PTPN3 / PTN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTPN3 gene (6 alternative transcripts): 
    NM_001145368.1  NM_001145369.1  NM_001145370.1  NM_001145371.1  NM_001145372.1  NM_002829.3  

    Unigene Cluster for PTPN3:

    Protein tyrosine phosphatase, non-receptor type 3
    Hs.436429  [show with all ESTs]
    Unigene Representative Sequence: NM_001145369
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447271 ENST00000374541 ENST00000497739 ENST00000262539 ENST00000412145(uc004beb.2)
    ENST00000446349(uc004bec.2) ENST00000394827
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK096975.1 AK296265.1 AK296388.1 AK303608.1 AK304434.1 AK308349.1 AK316066.1 AK316118.1 
    BC033716.1 BC126117.1 BC143848.1 BX648253.1 BX648735.1 CR749204.1 M64572.1 NR_026918.1 
    S39392.1 

    12 DOTS entries:

    DT.101979387  DT.92016697  DT.75173572  DT.91650494  DT.95272145  DT.92423622  DT.100739132  DT.92423621 
    DT.91728395  DT.95272147  DT.121200338  DT.121200318 

    24/180 AceView cDNA sequences (see all 180):

    H40246 BF475578 BM129305 BX648735 CB854789 BM980740 AL597961 BE790784 
    BM988026 BU078716 BQ020836 CA312309 AW614641 AU142086 NM_002829 CB851661 
    AW170611 BQ447162 BQ016336 CB850638 BC033716 F07320 BI335724 BM129571 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN3 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^
    SP1:                                -     -     -     -                 -                 -                                         -                       -   
    SP2:                                -     -     -     -                 -                 -                                         -                       -   
    SP3:                                                                    -                 -                                         -                       -   
    SP4:                                                                    -                 -                                         -     -                 -   
    SP5:                                -     -     -     -                                                                                                         

    ExUns: 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b · 30c
    SP1:                                      -     -                       -                 -                                             
    SP2:                                      -     -                       -                                                               
    SP3:                                      -     -                       -                 -                                             
    SP4:                                      -     -                       -                 -                                             
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for PTPN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPN3 expression in normal human tissues (normalized intensities)      PTPN3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTPN3 Expression
    About this image


    PTPN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             ganglion/cranial/facial VII   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Kidney (Urinary System)
             Metanephros
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See PTPN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPN3

    SOURCE GeneReport for Unigene cluster: Hs.436429
        SABiosciences Expression via Pathway-Focused PCR Array including PTPN3: 
              Protein Phosphatases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PTPN3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn31 , 5 protein tyrosine phosphatase, non-receptor type 31, 5 87.22(n)1
    92(a)1
      4 (31.66 cM)5
    5456221  NM_011207.21  NP_035337.21 
     571908415 
    chicken
    (Gallus gallus)
    Aves PTPN31 protein tyrosine phosphatase, non-receptor type 3 75.48(n)
    78.49(a)
      420963  XM_419047.3  XP_419047.3 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN36
    Uncharacterized protein
    73(a)
    1 ↔ 1
    6(57098560-57203114)
    zebrafish
    (Danio rerio)
    Actinopterygii ptpn31 protein tyrosine phosphatase, non-receptor type 3 62.06(n)
    59.54(a)
      407635  XM_682838.5  XP_687930.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ptpmeg3 protein tyrosine phosphatase 45(a)   61C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea ptp-13 protein tyrosine phosphatase (non
    receptor type) more
    51(a)
    (best of 8)
      III(3662582-3683374)   --


    ENSEMBL Gene Tree for PTPN3 (if available)
    TreeFam Gene Tree for PTPN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPN3 gene
    EPB41L52  EPB412  FRMD32  EPB41L12  EPB41L4B2  FARP12  PTPN42  FRMD52  
    EPB41L32  FRMD72  EPB41L4A2  FARP22  EPB41L22  
    18/36 SIMAP similar genes for PTPN3 using alignment to 4 protein entries:     PTN3_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0569    PTPN4    EPB41L4A    FARP1    DKFZp781C1038    PTN2
    RDX    BPTP-3    EPB41L1    PTPRH    PTPN2    DKFZp566K0524
    PTPN20A    PTPN20B    PTPRK    PTPRM    PTPRQ    PTPRA

    PTPN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2543 SNPs in PTPN3 are shown (see all 2543)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1939207981,2
    Cuntested1112199206(-) CATAGC/TGCGGA 8 A V mis10--------
    rs1403209511,2
    --112137510(+) CCCACA/GTCAAG 7 -- ds5001 int10--------
    rs1155429741,2
    F--112137527(+) GCCAGG/AGGGAG 7 -- ds5001 int11Minor allele frequency- A:0.04WA 118
    rs779865341,2
    C,F--112137528(+) CCAGGG/TGGAGA 7 -- ds5001 int11Minor allele frequency- T:0.13EA 120
    rs1178904571,2
    F--112137554(+) GGAGGT/GTTCCC 7 -- ds5001 int11Minor allele frequency- G:0.01NA 120
    rs1450779481,2
    --112137557(+) GGTTTC/TCCCCA 7 -- ds5001 int10--------
    rs109798481,2
    F--112137560(+) ttcccC/Tcatac 7 -- ds5001 int10--------
    rs1904407901,2
    --112137564(+) CCCATA/GCTGTT 7 -- ds5001 int10--------
    rs1822216321,2
    --112137573(+) TTCTCA/GTGGTG 7 -- ds5001 int10--------
    rs1871765321,2
    --112137600(+) AGATCA/GGATGG 7 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for PTPN3 (112137746 - 112260593 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PTPN3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv8557CNV Loss18304495
    nsv831685CNV Gain17160897
    dgv2410e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176877    OMIM disorders: --

    20/63 diseases for PTPN3 (see all 63):    About MalaCards
    bannayan-riley-ruvalcaba syndrome    ruvalcaba syndrome    scott syndrome    endocrine diseases
    non-functioning pituitary adenoma    functioning pituitary adenoma    type 1 diabetes    severe congenital neutropenia
    polyploidy    autonomic neuropathy    juvenile myelomonocytic leukemia    type 1 diabetes mellitus
    pituitary adenoma    noonan syndrome    neutropenia    hypersensitivity reaction type ii disease
    acute promyelocytic leukemia    pemphigus    tetanus    gestational diabetes

    3 diseases from the University of Copenhagen DISEASES database for PTPN3:
    Diabetes mellitus     Noonan syndrome     Hypersensitivity reaction type II disease

    PTPN3 for disorders           About GeneDecksing

    10/32 Novoseek inferred disease relationships for PTPN3 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetes autoimmune 50.7 1 12021124 (1)
    autoimmunity 45.6 3 20204370 (1), 8805677 (1)
    diabetes mellitus insulin-dependent 33.4 2 9670839 (1), 20088380 (1)
    ketosis 22.8 1 15059369 (1)
    ketoacidosis 20.4 1 15059369 (1)
    tumors 8.31 12 7548619 (1), 14676845 (1), 15155950 (1), 1347042 (1) (see all 12)
    autoimmune diseases 8.06 2 15759012 (1), 19768773 (1)
    virus infection 3.93 1 18988535 (1)
    hepatocellular carcinoma 3.45 1 7874267 (1)
    carcinoma lewis lung 2.5 1 9030244 (1)

    Genetic Association Database (GAD): PTPN3
    Human Genome Epidemiology (HuGE) Navigator: PTPN3 (3 documents)

    Export disorders for PTPN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPN3 gene, integrated from 9 sources (see all 647):
    (articles sorted by number of sources associating them with PTPN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin. (PubMed id 1648725)1, 2, 3, 9 Yang Q. and Tonks N.K. (1991)
    2. Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma. (PubMed id 7874267)1, 2, 9 Ikuta S....Yachi A. (1994)
    3. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)1, 2 Barr A.J.... Knapp S. (2009)
    4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (2008)
    5. cDNA cloning of new protein tyrosine phosphatases in the human colon. (PubMed id 1626183)1, 2 Arimura Y.... Yachi A. (1992)
    6. Suppression of hepatitis B viral gene expression by protein-tyrosine phosphatase PTPN3. (PubMed id 17588219)1, 9 Hsu E.C....Ting L.P. (2007)
    7. Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein. (PubMed id 9341175)1, 9 Zhang S.H....Tonks N.K. (1997)
    8. Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins. (PubMed id 8253532)1, 9 Itoh F....Yachi A. (1993)
    9. Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins. (PubMed id 17166906)1, 9 Jing M....Vande Pol S.B. (2007)
    10. Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. (PubMed id 17947517)1, 9 Topffer S....Steger G. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5774 HGNC: 9655 AceView: PTPN3 Ensembl:ENSG00000070159 euGenes: HUgn5774
    ECgene: PTPN3 H-InvDB: PTPN3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPN3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTPN3 gene:
    Search GeneIP for patents involving PTPN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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