Aliases for PTPN3 Gene
External Ids for PTPN3 Gene
Previous GeneCards Identifiers for PTPN3 Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
GeneCards Summary for PTPN3 Gene
PTPN3 (Protein Tyrosine Phosphatase, Non-Receptor Type 3) is a Protein Coding gene. Diseases associated with PTPN3 include Cholangiocarcinoma, Susceptibility To and Non-Functioning Pituitary Adenoma. Among its related pathways are Activation of cAMP-Dependent PKA and EGFR downregulation. GO annotations related to this gene include phosphatase activity and cytoskeletal protein binding. An important paralog of this gene is PTPN4.
UniProtKB/Swiss-Prot for PTPN3 Gene
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.