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PTPN3 Gene

protein-coding   GIFtS: 65
GCID: GC09M112138

Protein Tyrosine Phosphatase, Non-Receptor Type 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 31 2     EC 3.1.3.483 8
PTPH12 3 5     Cytoskeletal-Associated Protein Tyrosine Phosphatase2
Protein-Tyrosine Phosphatase H12 3     Tyrosine-Protein Phosphatase Non-Receptor Type 32
PTP-H12 3     

External Ids:    HGNC: 96551   Entrez Gene: 57742   Ensembl: ENSG000000701597   OMIM: 1768775   UniProtKB: P260453   

Export aliases for PTPN3 gene to outside databases

Previous GC identifers: GC09M102938 GC09M103872 GC09M105597 GC09M107520 GC09M109220 GC09M111177 GC09M081738


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPN3 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal
domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator
involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was
also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Feb 2009)

GeneCards Summary for PTPN3 Gene:
PTPN3 (protein tyrosine phosphatase, non-receptor type 3) is a protein-coding gene. Diseases associated with PTPN3 include bannayan-riley-ruvalcaba syndrome, and ruvalcaba syndrome. GO annotations related to this gene include protein tyrosine phosphatase activity and ATPase binding. An important paralog of this gene is EPB41L5.

UniProtKB/Swiss-Prot: PTN3_HUMAN, P26045
Function: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity

Gene Wiki entry for PTPN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPN3 gene promoter:
         E2F-4   E2F-3a   USF1   E2F-5   Nkx2-5   E2F-2   POU6F1 (c2)   E2F   E2F-1   USF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PTPN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31   Ensembl cytogenetic band:  9q31.3   HGNC cytogenetic band: 9q31

PTPN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M112138:  view genomic region     (about GC identifiers)

Start:
112,137,746 bp from pter      End:
112,260,593 bp from pter
Size:
122,848 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PTN3_HUMAN, P26045 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 3  
Size: 913 amino acids; 103990 Da
1 PDB 3D structure from and Proteopedia for PTPN3:
2B49 (3D)    
Secondary accessions: A0AUW9 E7EN99 E9PGU7
Alternative splicing: 3 isoforms:  P26045-1   P26045-2   P26045-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPN3: NX_P26045

Explore proteomics data for PTPN3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTPN3 (P26045) (see all 5)
     YPLDIVR  KCHQYWP  WPDHGVP  YIATQGP 


    See PTPN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001138840.1  NP_001138841.1  NP_001138842.1  NP_001138843.1  NP_001138844.1  NP_002820.3  

    ENSEMBL proteins: 
     ENSP00000363667   ENSP00000262539   ENSP00000416654   ENSP00000395384   ENSP00000378304  

    PTPN3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PTPN3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PTPN3
    GenScript Custom Purified and Recombinant Proteins Services for PTPN3
    Novus Biologicals PTPN3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTPN3

    PTPN3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for PTPN3
    Novus Biologicals PTPN3 Antibodies
    Abcam antibodies for PTPN3
    Cloud-Clone Corp. Antibodies for PTPN3
    ThermoFisher Antibodies for PTPN3
    LSBio Antibodies in human, mouse, rat for PTPN3

    PTPN3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTPN3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTPN3
    Cloud-Clone Corp. CLIAs for PTPN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    Selected InterPro protein domains (see all 14):
     IPR019748 FERM_central
     IPR012151 Tyr_Pase_non-rcpt_typ-3/4
     IPR019750 Band_41_fam
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt

    Graphical View of Domain Structure for InterPro Entry P26045

    ProtoNet protein and cluster: P26045

    4 Blocks protein domains:
    IPB000242 Protein tyrosine phosphatase signature
    IPB000299 Band 4.1 domain
    IPB000798 ERM family signature
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: PTN3_HUMAN, P26045
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    PTPN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN3_HUMAN, P26045
    Function: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN3:
    protein tyrosine phosphatase,non receptor type 3,(ERM) family member,responding and participating in
    reorganization of membrane-cytoplasmic interactions

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IPI10364224
    GO:0004725protein tyrosine phosphatase activity IDA19167335
    GO:0005515protein binding IPI10364224
    GO:0008092cytoskeletal protein binding IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
         
    PTPN3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PTPN3:
     Decreased focal adhesion (FA)   Increased cell death in HCT116  Increased cell death in breast  Synthetic lethal with paclitax 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ptpn3):
     growth/size/body  immune system  no phenotypic analysis  normal  skeleton 

    PTPN3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptpn3tm1Pdk for PTPN3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTPN3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PTPN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPN3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPN3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTPN3:
    hsa-mir-16-5p (MIRT032073), hsa-mir-21-5p (MIRT031028), hsa-mir-103a-3p (MIRT027192)

    Block miRNA regulation of human, mouse, rat PTPN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPN3 (see all 93):
    hsa-miR-1321 hsa-miR-15a hsa-miR-199a-3p hsa-miR-106a hsa-miR-1258 hsa-miR-1260b hsa-miR-128 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidPTPN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PTPN3
    Predesigned siRNA for gene silencing in human, mouse, rat PTPN3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTPN3

    Clone
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    OriGene clones in human, mouse for PTPN3 (see all 36)
    OriGene ORF clones in mouse, rat for PTPN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): PTPN3 (NM_002829)
    Sino Biological Human cDNA Clone for PTPN3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PTPN3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTN3_HUMAN, P26045: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    extracellular2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10940933
    GO:0005856cytoskeleton IEA--
    GO:0009898cytoplasmic side of plasma membrane IDA10940933

    PTPN3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPN3 About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2TWEAK Pathway
    Apoptotic Pathways Triggered By HIV10.42
    3PAK Pathway
    Epithelial Adherens Junctions0.36

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PTPN3 (see all 6)
        Activation of PKA through GPCR
    PKA Signaling
    Apoptotic Pathways Triggered By HIV1
    cAMP Pathway
    Activation of cAMP-Dependent PKA



        Pathway & Disease-focused RT2 Profiler PCR Array including PTPN3: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for PTPN3 (P260451, 2, 3 ENSP000002625394) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GHRP109121, 2, 3, ENSP000002308824EBI-1047946,EBI-286316 MINT-6797590 MINT-6797814 MINT-6797489 MINT-6797621 MINT-6797890 I2D: score=3 STRING: ENSP00000230882
    VCPP550721, 3, ENSP000003517774EBI-1047946,EBI-355164 I2D: score=2 STRING: ENSP00000351777
    SFNP319472, 3MINT-3975189 I2D: score=2 
    YWHAZP631042, 3MINT-3317913 I2D: score=1 
    YWHABP319462, 3, ENSP000003001614MINT-8005194 MINT-8005187 I2D: score=4 STRING: ENSP00000300161
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IDA10364224
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS1648725
    GO:0045930negative regulation of mitotic cell cycle IDA10364224
    GO:0051045negative regulation of membrane protein ectodomain proteolysis IMP12207026

    PTPN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPN3 (PTN3)

    2 HMDB Compounds for PTPN3    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for PTPN3 gene (see all 93)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 92.5 1494 14983067 (6), 12941469 (6), 7907795 (5), 9275062 (4) (see all 99)
    sodium orthovanadate 89.7 53 1655274 (1), 15004519 (1), 7673119 (1), 8941358 (1) (see all 53)
    vanadate 88.5 84 9564854 (2), 7883973 (2), 9535775 (2), 1312177 (2) (see all 76)
    phenylarsine oxide 86.4 51 9505351 (2), 8110195 (2), 1325458 (1), 10385133 (1) (see all 36)
    phosphotyrosine 82.9 18 7692368 (2), 1316270 (1), 7498427 (1), 1648262 (1) (see all 17)
    genistein 74 28 15935067 (1), 8941358 (1), 11329620 (1), 7744319 (1) (see all 26)
    threonine 73.1 54 12769677 (3), 18073210 (2), 12673251 (1), 1330783 (1) (see all 48)
    dephostatin 71.2 5 9381983 (1), 19707507 (1), 7572353 (1), 11012840 (1)
    herbimycin a 71 8 15935067 (1), 8683142 (1), 9111028 (1), 9350436 (1) (see all 8)
    bpv(phen) 70.8 2 12581886 (1), 18216177 (1)



    PTPN3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PTPN3 gene (6 alternative transcripts): 
    NM_001145368.1  NM_001145369.1  NM_001145370.1  NM_001145371.1  NM_001145372.1  NM_002829.3  

    Unigene Cluster for PTPN3:

    Protein tyrosine phosphatase, non-receptor type 3
    Hs.436429  [show with all ESTs]
    Unigene Representative Sequence: NM_001145369
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447271 ENST00000374541 ENST00000497739 ENST00000262539 ENST00000412145(uc004beb.2)
    ENST00000446349(uc004bec.2) ENST00000394827
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PTPN3 (see all 93):
    hsa-miR-1321 hsa-miR-15a hsa-miR-199a-3p hsa-miR-106a hsa-miR-1258 hsa-miR-1260b hsa-miR-128 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidPTPN3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PTPN3
    Clone
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    OriGene ORF clones in mouse, rat for PTPN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): PTPN3 (NM_002829)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN3
    Primer
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    OriGene qPCR primer pairs and template standards for PTPN3
    OriGene qSTAR qPCR primer pairs in human, mouse for PTPN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PTPN3
      QuantiTect SYBR Green Assays in human, mouse, rat PTPN3
      QuantiFast Probe-based Assays in human, mouse, rat PTPN3

    Additional mRNA sequence: 

    AK096975.1 AK296265.1 AK296388.1 AK303608.1 AK304434.1 AK308349.1 AK316066.1 AK316118.1 
    BC033716.1 BC126117.1 BC143848.1 BX648253.1 BX648735.1 CR749204.1 M64572.1 NR_026918.1 
    S39392.1 

    12 DOTS entries:

    DT.101979387  DT.92016697  DT.75173572  DT.91650494  DT.95272145  DT.92423622  DT.100739132  DT.92423621 
    DT.91728395  DT.95272147  DT.121200338  DT.121200318 

    Selected AceView cDNA sequences (see all 180):

    CB854789 BM982508 BQ016336 AI380481 BE790784 AU142086 BG767944 CK819572 
    H40246 BM129571 BX648735 BU624870 BM129532 BX099807 AW614641 BX648253 
    BF475578 AW517822 BF437384 CA312309 BU078716 BM988026 BU078992 BF446162 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTPN3 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^
    SP1:                                -     -     -     -                 -                 -                                         -                       -   
    SP2:                                -     -     -     -                 -                 -                                         -                       -   
    SP3:                                                                    -                 -                                         -                       -   
    SP4:                                                                    -                 -                                         -     -                 -   
    SP5:                                -     -     -     -                                                                                                         

    ExUns: 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b · 30c
    SP1:                                      -     -                       -                 -                                             
    SP2:                                      -     -                       -                                                               
    SP3:                                      -     -                       -                 -                                             
    SP4:                                      -     -                       -                 -                                             
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for PTPN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTPN3 Expression
    About this image


    PTPN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
    PTPN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436429
        Pathway & Disease-focused RT2 Profiler PCR Array including PTPN3: 
              Protein Phosphatases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTPN3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn31 , 5 protein tyrosine phosphatase, non-receptor type 31, 5 87.22(n)1
    92(a)1
      4 (31.66 cM)5
    5456221  NM_011207.21  NP_035337.21 
     571908415 
    chicken
    (Gallus gallus)
    Aves PTPN31 protein tyrosine phosphatase, non-receptor type 3 75.56(n)
    78.81(a)
      420963  XM_419047.4  XP_419047.4 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN36
    protein tyrosine phosphatase, non-receptor type 3
    73(a)
    1 ↔ 1
    6(57098560-57203114)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ptpn31 protein tyrosine phosphatase, non-receptor type 3 69.26(n)
    72.7(a)
      780392  NM_001079462.1  NP_001072930.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ptpn31 protein tyrosine phosphatase, non-receptor type 3 61.96(n)
    59.11(a)
      407635  XM_682838.6  XP_687930.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ptpmeg3 protein tyrosine phosphatase 45(a)   61C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea ptp-13 protein tyrosine phosphatase (non
    receptor type) more
    51(a)
    (best of 8)
      III(3662582-3683374)   --


    ENSEMBL Gene Tree for PTPN3 (if available)
    TreeFam Gene Tree for PTPN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPN3 gene
    EPB41L52  EPB412  FRMD32  EPB41L12  EPB41L4B2  FARP12  PTPN42  FRMD52  
    FRMD72  EPB41L32  EPB41L4A2  FARP22  EPB41L22  
    Selected SIMAP similar genes for PTPN3 using alignment to 4 protein entries:     PTN3_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0569    PTPN4    EPB41L4A    FARP1    DKFZp781C1038    PTN2
    RDX    BPTP-3    EPB41L1    PTPRH    PTPN2    DKFZp566K0524
    PTPN20A    PTPN20B    PTPRK    PTPRM    PTPRA    PTPRD

    PTPN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPN3 (see all 2543)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1939207981,2
    Cuntested1112199206(-) CATAGC/TGCGGA 8 A V mis10--------
    rs1403209511,2
    --112137510(+) CCCACA/GTCAAG 7 -- ds5001 int10--------
    rs1155429741,2
    F--112137527(+) GCCAGG/AGGGAG 7 -- ds5001 int11Minor allele frequency- A:0.04WA 118
    rs779865341,2
    C,F--112137528(+) CCAGGG/TGGAGA 7 -- ds5001 int11Minor allele frequency- T:0.13EA 120
    rs1178904571,2
    F--112137554(+) GGAGGT/GTTCCC 7 -- ds5001 int11Minor allele frequency- G:0.01NA 120
    rs1450779481,2
    --112137557(+) GGTTTC/TCCCCA 7 -- ds5001 int10--------
    rs109798481,2
    F--112137560(+) ttcccC/Tcatac 7 -- ds5001 int10--------
    rs1904407901,2
    --112137564(+) CCCATA/GCTGTT 7 -- ds5001 int10--------
    rs1822216321,2
    --112137573(+) TTCTCA/GTGGTG 7 -- ds5001 int10--------
    rs1871765321,2
    --112137600(+) AGATCA/GGATGG 7 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for PTPN3 (112137746 - 112260593 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PTPN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv8557CNV Loss18304495
    nsv831685CNV Gain17160897
    dgv2410e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTPN3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176877    OMIM disorders: --

    Selected diseases for PTPN3 (see all 60):    
    About MalaCards
    bannayan-riley-ruvalcaba syndrome    ruvalcaba syndrome    scott syndrome    non-functioning pituitary adenoma
    functioning pituitary adenoma    severe congenital neutropenia    pituitary adenoma    polyploidy
    type 1 diabetes    autonomic neuropathy    type 1 diabetes mellitus    noonan syndrome
    neutropenia    hypersensitivity reaction type ii disease    adenoma    pemphigus
    tetanus    gestational diabetes    acute promyelocytic leukemia    pheochromocytoma

    3 diseases from the University of Copenhagen DISEASES database for PTPN3:
    Diabetes mellitus     Noonan syndrome     Hypersensitivity reaction type II disease

    PTPN3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PTPN3 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetes autoimmune 50.7 1 12021124 (1)
    autoimmunity 45.6 3 20204370 (1), 8805677 (1)
    diabetes mellitus insulin-dependent 33.4 2 9670839 (1), 20088380 (1)
    ketosis 22.8 1 15059369 (1)
    ketoacidosis 20.4 1 15059369 (1)
    tumors 8.31 12 7548619 (1), 14676845 (1), 15155950 (1), 1347042 (1) (see all 12)
    autoimmune diseases 8.06 2 15759012 (1), 19768773 (1)
    virus infection 3.93 1 18988535 (1)
    hepatocellular carcinoma 3.45 1 7874267 (1)
    carcinoma lewis lung 2.5 1 9030244 (1)

    Genetic Association Database (GAD): PTPN3
    Human Genome Epidemiology (HuGE) Navigator: PTPN3 (3 documents)

    Export disorders for PTPN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPN3 gene, integrated from 10 sources (see all 647):
    (articles sorted by number of sources associating them with PTPN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin. (PubMed id 1648725)1, 2, 3, 9 Yang Q. and Tonks N.K. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma. (PubMed id 7874267)1, 2, 9 Ikuta S....Yachi A. (J. Gastroenterol. 1994)
    3. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)1, 2 Barr A.J.... Knapp S. (Cell 2009)
    4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    5. cDNA cloning of new protein tyrosine phosphatases in the human colon. (PubMed id 1626183)1, 2 Arimura Y.... Yachi A. (Tumor Biol. 1992)
    6. Suppression of hepatitis B viral gene expression by protein-tyrosine phosphatase PTPN3. (PubMed id 17588219)1, 9 Hsu E.C....Ting L.P. (J. Biomed. Sci. 2007)
    7. Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein. (PubMed id 9341175)1, 9 Zhang S.H....Tonks N.K. (J. Biol. Chem. 1997)
    8. Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins. (PubMed id 8253532)1, 9 Itoh F....Yachi A. (Int. J. Cancer 1993)
    9. Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins. (PubMed id 17166906)1, 9 Jing M....Vande Pol S.B. (J. Virol. 2007)
    10. Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. (PubMed id 17947517)1, 9 TAPpffer S....Steger G. (J. Gen. Virol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5774 HGNC: 9655 AceView: PTPN3 Ensembl:ENSG00000070159 euGenes: HUgn5774
    ECgene: PTPN3 H-InvDB: PTPN3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPN3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPN3 gene:
    Search GeneIP for patents involving PTPN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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