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Aliases for PTPN23 Gene

Aliases for PTPN23 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 23 2 3 5
  • His Domain-Containing Protein Tyrosine Phosphatase 3 4
  • Protein Tyrosine Phosphatase TD14 3 4
  • EC 3.1.3.48 4 63
  • PTP-TD14 3 4
  • HD-PTP 3 4
  • KIAA1471 4
  • HDPTP 3

External Ids for PTPN23 Gene

Previous GeneCards Identifiers for PTPN23 Gene

  • GC03P047211
  • GC03P046642
  • GC03P047383
  • GC03P047343

Summaries for PTPN23 Gene

GeneCards Summary for PTPN23 Gene

PTPN23 (Protein Tyrosine Phosphatase, Non-Receptor Type 23) is a Protein Coding gene. Among its related pathways are PAK Pathway. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is RHPN1.

UniProtKB/Swiss-Prot for PTPN23 Gene

  • Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.

Gene Wiki entry for PTPN23 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN23 Gene

Genomics for PTPN23 Gene

Regulatory Elements for PTPN23 Gene

Promoters for PTPN23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTPN23 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPN23 Gene

Chromosome:
3
Start:
47,380,982 bp from pter
End:
47,413,441 bp from pter
Size:
32,460 bases
Orientation:
Plus strand

Genomic View for PTPN23 Gene

Genes around PTPN23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN23 Gene

Proteins for PTPN23 Gene

  • Protein details for PTPN23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3S7-PTN23_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 23
    Protein Accession:
    Q9H3S7
    Secondary Accessions:
    • A8K0D7
    • Q7KZF8
    • Q8N6Z5
    • Q9BSR5
    • Q9P257
    • Q9UG03
    • Q9UMZ4

    Protein attributes for PTPN23 Gene

    Size:
    1636 amino acids
    Molecular mass:
    178974 Da
    Quaternary structure:
    • Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B.
    SequenceCaution:
    • Sequence=BAA95995.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPN23 Gene

neXtProt entry for PTPN23 Gene

Proteomics data for PTPN23 Gene at MOPED

Selected DME Specific Peptides for PTPN23 Gene

Post-translational modifications for PTPN23 Gene

  • Ubiquitination at Lys 32, Lys 279, Lys 285, Lys 288, and Lys 1635
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPN23 Gene

Domains & Families for PTPN23 Gene

Gene Families for PTPN23 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H3S7

UniProtKB/Swiss-Prot:

PTN23_HUMAN :
  • Contains 1 BRO1 domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
  • Contains 2 TPR repeats.
Domain:
  • Contains 1 BRO1 domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Similarity:
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with PTPN23: view

Function for PTPN23 Gene

Molecular function for PTPN23 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.

Enzyme Numbers (IUBMB) for PTPN23 Gene

genes like me logo Genes that share phenotypes with PTPN23: view

Animal Models for PTPN23 Gene

MGI Knock Outs for PTPN23:

Animal Model Products

miRNA for PTPN23 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPN23 Gene

Localization for PTPN23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN23 Gene

Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPN23 Gene COMPARTMENTS Subcellular localization image for PTPN23 gene
Compartment Confidence
cytoskeleton 5
endosome 5
extracellular 5
nucleus 5
cytosol 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PTPN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005769 early endosome IDA 21757351
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PTPN23: view

Pathways & Interactions for PTPN23 Gene

SuperPathways for PTPN23 Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPN23: view

Pathways by source for PTPN23 Gene

1 Qiagen pathway for PTPN23 Gene

Gene Ontology (GO) - Biological Process for PTPN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0010633 negative regulation of epithelial cell migration IMP 21724833
GO:0035335 peptidyl-tyrosine dephosphorylation IMP 21724833
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP 21757351
GO:0060271 cilium morphogenesis IMP 20393563
genes like me logo Genes that share ontologies with PTPN23: view

No data available for SIGNOR curated interactions for PTPN23 Gene

Drugs & Compounds for PTPN23 Gene

(3) Additional Compounds for PTPN23 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTPN23: view

Transcripts for PTPN23 Gene

Unigene Clusters for PTPN23 Gene

Protein tyrosine phosphatase, non-receptor type 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN23 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: -
SP3:
SP4:
SP5:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for PTPN23 Gene

GeneLoc Exon Structure for
PTPN23
ECgene alternative splicing isoforms for
PTPN23

Expression for PTPN23 Gene

mRNA expression in normal human tissues for PTPN23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPN23 Gene

This gene is overexpressed in Lymph node (8.8) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN23 Gene



SOURCE GeneReport for Unigene cluster for PTPN23 Gene Hs.25524

genes like me logo Genes that share expression patterns with PTPN23: view

Protein tissue co-expression partners for PTPN23 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTPN23 Gene

Orthologs for PTPN23 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPN23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPN23 35
  • 98.82 (n)
  • 98.96 (a)
PTPN23 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPN23 36
  • 85 (a)
OneToOne
PTPN23 35
  • 86.99 (n)
  • 91 (a)
dog
(Canis familiaris)
Mammalia PTPN23 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpn23 35
  • 85.67 (n)
  • 90.99 (a)
Ptpn23 16
Ptpn23 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPN23 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpn23 35
  • 85.64 (n)
  • 89.99 (a)
chicken
(Gallus gallus)
Aves PTPN23 36
  • 83 (a)
OneToOne
PTPN23 35
  • 80.13 (n)
  • 84.79 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn23 35
  • 69.49 (n)
  • 71.6 (a)
zebrafish
(Danio rerio)
Actinopterygii ptpn23a 36
  • 50 (a)
OneToMany
ptpn23b 36
  • 49 (a)
OneToMany
Dr.13034 35
ptpn23a 35
  • 65.98 (n)
  • 68.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9311 37
  • 39 (a)
mop 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y53H1C.2 37
  • 28 (a)
ego-2 36
  • 24 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM20 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for PTPN23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN23 Gene

ENSEMBL:
Gene Tree for PTPN23 (if available)
TreeFam:
Gene Tree for PTPN23 (if available)

Paralogs for PTPN23 Gene

Paralogs for PTPN23 Gene

(7) SIMAP similar genes for PTPN23 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PTPN23: view

Variants for PTPN23 Gene

Sequence variations from dbSNP and Humsavar for PTPN23 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs900693 -- 47,395,959(-) GAGCC(C/G/T)TGACC intron-variant
rs900694 -- 47,395,658(-) AGAAA(C/T)ATGTG intron-variant
rs1531874 -- 47,408,090(+) CCGCC(C/T)GGGGT intron-variant
rs1531875 -- 47,411,296(+) TATGA(A/G)CATCC reference, synonymous-codon
rs3733090 -- 47,411,086(-) GGTAC(C/T)GGACC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PTPN23 Gene

Variant ID Type Subtype PubMed ID
nsv428417 CNV Loss 18775914
nsv876756 CNV Gain 21882294
nsv3802 CNV Loss 18451855
nsv3803 CNV Insertion 18451855
nsv3804 CNV Insertion 18451855

Variation tolerance for PTPN23 Gene

Residual Variation Intolerance Score: 2.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.37; 76.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPN23 Gene

HapMap Linkage Disequilibrium report
PTPN23
Human Gene Mutation Database (HGMD)
PTPN23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN23 Gene

Disorders for PTPN23 Gene

Relevant External Links for PTPN23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPN23

No disorders were found for PTPN23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPN23 Gene

Publications for PTPN23 Gene

  1. HD-PTP: a novel protein tyrosine phosphatase gene on human chromosome 3p21.3. (PMID: 11095967) Toyooka S. … Shimizu K. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23 67
  2. Divergent Bro1 domains share the capacity to bind human immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particle production. (PMID: 19403673) Popov S. … GAPttlinger H.G. (J. Virol. 2009) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PTPN23 Gene

Sources for PTPN23 Gene

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