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Aliases for PTPN23 Gene

Aliases for PTPN23 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 23 2 3
  • His Domain-Containing Protein Tyrosine Phosphatase 3 4
  • Protein Tyrosine Phosphatase TD14 3 4
  • EC 4 63
  • PTP-TD14 3 4
  • KIAA1471 4 6
  • HD-PTP 3 4
  • HDPTP 3 6
  • Tyrosine-Protein Phosphatase Non-Receptor Type 23 3

External Ids for PTPN23 Gene

Previous GeneCards Identifiers for PTPN23 Gene

  • GC03P047211
  • GC03P046642
  • GC03P047383
  • GC03P047343

Summaries for PTPN23 Gene

GeneCards Summary for PTPN23 Gene

PTPN23 (Protein Tyrosine Phosphatase, Non-Receptor Type 23) is a Protein Coding gene. Among its related pathways are PAK Pathway. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is RHPN1.

UniProtKB/Swiss-Prot for PTPN23 Gene

  • Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.

Gene Wiki entry for PTPN23 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN23 Gene

Genomics for PTPN23 Gene

Regulatory Elements for PTPN23 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPN23 Gene

47,380,893 bp from pter
47,413,441 bp from pter
32,549 bases
Plus strand

Genomic View for PTPN23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN23 Gene

Proteins for PTPN23 Gene

  • Protein details for PTPN23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 23
    Protein Accession:
    Secondary Accessions:
    • A8K0D7
    • Q7KZF8
    • Q8N6Z5
    • Q9BSR5
    • Q9P257
    • Q9UG03
    • Q9UMZ4

    Protein attributes for PTPN23 Gene

    1636 amino acids
    Molecular mass:
    178974 Da
    Quaternary structure:
    • Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B.
    • Sequence=BAA95995.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPN23 Gene

neXtProt entry for PTPN23 Gene

Proteomics data for PTPN23 Gene at MOPED

Selected DME Specific Peptides for PTPN23 Gene

Post-translational modifications for PTPN23 Gene

  • Ubiquitination at Lys32, Lys279, Lys285, Lys288, and Lys1635
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPN23 Gene

Domains for PTPN23 Gene

Gene Families for PTPN23 Gene

  • PTPN :Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

Graphical View of Domain Structure for InterPro Entry



  • Q9H3S7
  • Contains 1 BRO1 domain.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with PTPN23: view

Function for PTPN23 Gene

Molecular function for PTPN23 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.

Enzyme Numbers (IUBMB) for PTPN23 Gene

Gene Ontology (GO) - Molecular Function for PTPN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IMP 21724833
GO:0005515 protein binding IPI 17174262
GO:0016791 phosphatase activity --
GO:0019901 protein kinase binding IPI 21724833
genes like me logo Genes that share ontologies with PTPN23: view
genes like me logo Genes that share phenotypes with PTPN23: view

Animal Model Products

CRISPR Products

miRNA for PTPN23 Gene

miRTarBase miRNAs that target PTPN23

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PTPN23 Gene

Localization for PTPN23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN23 Gene

Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.

Subcellular locations from

Jensen Localization Image for PTPN23 Gene COMPARTMENTS Subcellular localization image for PTPN23 gene
Compartment Confidence
cytoskeleton 5
endosome 5
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21179510
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 21179510
GO:0005768 endosome IDA 21179510
GO:0005769 early endosome IDA 21757351
genes like me logo Genes that share ontologies with PTPN23: view

Pathways for PTPN23 Gene

SuperPathways for PTPN23 Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPN23: view

Pathways by source for PTPN23 Gene

1 Qiagen pathway for PTPN23 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0010633 negative regulation of epithelial cell migration IMP 21724833
GO:0015031 protein transport IEA --
GO:0016311 dephosphorylation --
GO:0030334 regulation of cell migration --
genes like me logo Genes that share ontologies with PTPN23: view

Compounds for PTPN23 Gene

(2) HMDB Compounds for PTPN23 Gene

Compound Synonyms Cas Number PubMed IDs
  • NFB Orthophosphate
  • Dihydrogen oxide
genes like me logo Genes that share compounds with PTPN23: view

Transcripts for PTPN23 Gene

Unigene Clusters for PTPN23 Gene

Protein tyrosine phosphatase, non-receptor type 23:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN23

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PTPN23

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN23 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: -

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27

Relevant External Links for PTPN23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPN23 Gene

mRNA expression in normal human tissues for PTPN23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN23 Gene

SOURCE GeneReport for Unigene cluster for PTPN23 Gene Hs.25524

genes like me logo Genes that share expressions with PTPN23: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTPN23 Gene

Orthologs for PTPN23 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPN23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTPN23 35
  • 98.82 (n)
  • 98.96 (a)
PTPN23 36
  • 97 (a)
(Bos Taurus)
Mammalia PTPN23 35
  • 86.99 (n)
  • 91 (a)
PTPN23 36
  • 85 (a)
(Canis familiaris)
Mammalia PTPN23 36
  • 86 (a)
(Mus musculus)
Mammalia Ptpn23 35
  • 85.67 (n)
  • 90.99 (a)
Ptpn23 16
Ptpn23 36
  • 88 (a)
(Monodelphis domestica)
Mammalia PTPN23 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Ptpn23 35
  • 85.64 (n)
  • 89.99 (a)
(Gallus gallus)
Aves PTPN23 35
  • 80.13 (n)
  • 84.79 (a)
PTPN23 36
  • 83 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
-- 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn23 35
  • 69.49 (n)
  • 71.6 (a)
(Danio rerio)
Actinopterygii Dr.13034 35
ptpn23a 35
  • 65.98 (n)
  • 68.54 (a)
ptpn23a 36
  • 50 (a)
ptpn23b 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta mop 36
  • 27 (a)
CG9311 37
  • 39 (a)
(Caenorhabditis elegans)
Secernentea ego-2 36
  • 24 (a)
Y53H1C.2 37
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM20 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for PTPN23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN23 Gene

Gene Tree for PTPN23 (if available)
Gene Tree for PTPN23 (if available)

Paralogs for PTPN23 Gene

Paralogs for PTPN23 Gene

Selected SIMAP similar genes for PTPN23 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PTPN23: view

Variants for PTPN23 Gene

Sequence variations from dbSNP and Humsavar for PTPN23 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs900688 -- 47,407,568(+) GACAC(C/T)CTTCA synonymous-codon, reference
rs900689 -- 47,410,597(+) ATCCC(A/G/T)GCACA synonymous-codon, reference
rs900693 -- 47,395,959(-) GAGCC(C/G/T)TGACC intron-variant
rs900694 -- 47,395,658(-) AGAAA(C/T)ATGTG intron-variant
rs922957 -- 47,380,662(-) AGAGC(C/G)GTGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PTPN23 Gene

Variant ID Type Subtype PubMed ID
nsv428417 CNV Loss 18775914
nsv876756 CNV Gain 21882294
nsv3802 CNV Loss 18451855
nsv3803 CNV Insertion 18451855
nsv3804 CNV Insertion 18451855

Relevant External Links for PTPN23 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN23 Gene

Disorders for PTPN23 Gene

No disorders were found for PTPN23 Gene.

No data available for UniProtKB/Swiss-Prot for PTPN23 Gene

Publications for PTPN23 Gene

  1. HD-PTP: a novel protein tyrosine phosphatase gene on human chromosome 3p21.3. (PMID: 11095967) Toyooka S. … Shimizu K. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. Divergent Bro1 domains share the capacity to bind human immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particle production. (PMID: 19403673) Popov S. … GAPttlinger H.G. (J. Virol. 2009) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. Functional genomic screen for modulators of ciliogenesis and cilium length. (PMID: 20393563) Kim J. … Gleeson J.G. (Nature 2010) 3 4

Products for PTPN23 Gene

Sources for PTPN23 Gene

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