Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PTPN22 Gene

protein-coding   GIFtS: 65
GCID: GC01M114356

Protein Tyrosine Phosphatase, Non-Receptor Type 22 (Lymphoid)

(Previous names: protein tyrosine phosphatase, non-receptor type 8)
(Previous symbol: PTPN8)
  See PTPN22-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 22 (Lymphoid)1 2     LYP2 5
PTPN81 2 3 5     LYP12
PEP2 3 5     LYP22
Protein Tyrosine Phosphatase, Non-Receptor Type 81 2     Lymphoid-Specific Protein Tyrosine Phosphatase2
Hematopoietic Cell Protein-Tyrosine Phosphatase 70Z-PEP2 3     Tyrosine-Protein Phosphatase Non-Receptor Type 222
Lymphoid Phosphatase2 3     EC 3.1.3.483
PEST-Domain Phosphatase2 3     LyP3

External Ids:    HGNC: 96521   Entrez Gene: 261912   Ensembl: ENSG000001342427   OMIM: 6007165   UniProtKB: Q9Y2R23   

Export aliases for PTPN22 gene to outside databases

Previous GC identifers: GC01M114770 GC01M113238 GC01M113456 GC01M113655 GC01M114003 GC01M114157 GC01M112214


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PTPN22 Gene:
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The
encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter
protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in
this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis,
systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct
isoforms have been described. (provided by RefSeq, Mar 2009)

GeneCards Summary for PTPN22 Gene:
PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) is a protein-coding gene. Diseases associated with PTPN22 include rheumatoid arthritis, and temporal arteritis. GO annotations related to this gene include kinase binding and SH3 domain binding. An important paralog of this gene is PTPN1.

UniProtKB/Swiss-Prot: PTN22_HUMAN, Q9Y2R2
Function: Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src
family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling
molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394'
residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator
SKAP2

Gene Wiki entry for PTPN22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPN22 gene promoter:
         PPAR-gamma1   AML1a   GATA-3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN22 promoter sequence
   Search Chromatin IP Primers for PTPN22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

PTPN22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN22 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M114356:  view genomic region     (about GC identifiers)

Start:
114,356,433 bp from pter      End:
114,414,381 bp from pter
Size:
57,949 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PTN22_HUMAN, Q9Y2R2 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 22  
Size: 807 amino acids; 91705 Da
Subunit: Interacts with CSK. Interacts with LPXN (By similarity). Interacts with CBL
Selected PDB 3D structures from and Proteopedia for PTPN22 (see all 8):
2P6X (3D)        2QCJ (3D)        2QCT (3D)        3BRH (3D)        3H2X (3D)        3OLR (3D)    
Secondary accessions: A0N0K6 B1ALC8 D4NZ71 E9PPI1 O95063 O95064 Q6IPX8 Q8WVM1
Alternative splicing: 6 isoforms:  Q9Y2R2-1   Q9Y2R2-2   Q9Y2R2-3   Q9Y2R2-4   Q9Y2R2-5   Q9Y2R2-6   (Lacks most of the phosphatase domain and functions as a dominant negative isoform of the full length PTPN22)

Explore the universe of human proteins at neXtProt for PTPN22: NX_Q9Y2R2

Explore proteomics data for PTPN22 at MOPED

Post-translational modifications: 

  • Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family
    kinases1
  • Ubiquitination2 at Lys315, Lys411, Lys429, Lys448, Lys506
  • Modification sites at PhosphoSitePlus

  • See PTPN22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180360.1  NP_036543.4  NP_057051.3  

    ENSEMBL proteins: 
     ENSP00000433141   ENSP00000352833   ENSP00000435176   ENSP00000431249   ENSP00000388229  
     ENSP00000432674   ENSP00000434932   ENSP00000439372  

    PTPN22 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PTPN22
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PTPN22
    GenScript Custom Purified and Recombinant Proteins Services for PTPN22
    Novus Biologicals PTPN22 Proteins
    Novus Biologicals PTPN22 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTPN22

     
    Search eBioscience for Proteins for PTPN22 

     
    antibodies-online proteins for PTPN22 (5 products) 

     
    antibodies-online peptides for PTPN22

    PTPN22 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PTPN22 (Lyp)
    Cell Signaling Technology (CST) Antibodies for PTPN22 
    OriGene Antibodies for PTPN22
    OriGene Custom Antibody Services for PTPN22
    Novus Biologicals PTPN22 Antibodies
    Abcam antibodies for PTPN22
    Cloud-Clone Corp. Antibodies for PTPN22
    ThermoFisher Antibodies for PTPN22
    antibodies-online antibodies for PTPN22 (37 products) 

    PTPN22 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTPN22
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTPN22
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTPN22
    Cloud-Clone Corp. CLIAs for PTPN22
    Search eBioscience for ELISAs for PTPN22 
    antibodies-online kits for PTPN22 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    4 InterPro protein domains:
     IPR016276 Non-rcpt_Tyr_Pase_8/22
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry Q9Y2R2

    ProtoNet protein and cluster: Q9Y2R2

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTN22_HUMAN, Q9Y2R2
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPN22           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN22_HUMAN, Q9Y2R2
    Function: Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src
    family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling
    molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394'
    residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator
    SKAP2
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Enzyme regulation: Down-regulated by phosphorylation

         Genatlas biochemistry entry for PTPN22:
    Protein tyrosine-phosphatase non receptor type 22,lymphoid-specific,involved in regulation of the function of
    protooncogene CBL

         Enzyme Number (IUBMB): EC 3.1.3.481

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IDA10068674
    GO:0005515protein binding IPI10068674
    GO:0016791phosphatase activity ----
    GO:0017124SH3 domain binding ISS--
    GO:0019900kinase binding ISS--
         
    Find genes that share ontologies with PTPN22           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PTPN22:
     Decreased focal adhesion (FA)   Increased apoptosis  Upregulation of Wnt/beta-caten 

         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ptpn22):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     renal/urinary system  respiratory system 

    Find genes that share phenotypes with PTPN22           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTPN22: Ptpn22tm1Achn Ptpn22tm2Achn

       genOway: Develop your customized and physiologically relevant rodent model for PTPN22

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTPN22:
    hsa-mir-1 (MIRT023898), hsa-mir-181a-5p (MIRT006484)

    Block miRNA regulation of human, mouse, rat PTPN22 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PTPN22:
    hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidPTPN22 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PTPN22
    Predesigned siRNA for gene silencing in human, mouse, rat PTPN22

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTPN22

    Clone
    Products:
         
    OriGene clones in human, mouse for PTPN22 (see all 15)
    OriGene ORF clones in mouse, rat for PTPN22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PTPN22 (NM_015967)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN22

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PTPN22
    Browse ESI BIO Cell Lines and PureStem Progenitors for PTPN22 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PTN22_HUMAN, Q9Y2R2: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10940933
    GO:0005737cytoplasm TAS--
    GO:0009898cytoplasmic side of plasma membrane IDA10940933
    GO:0048471perinuclear region of cytoplasm IDA10068674

    Find genes that share ontologies with PTPN22           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PTPN22 About    
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2phospholipases
    Anandamide biosynthesis and metabolism0.34
    3CD28 co-stimulation
    CTLA4 Signaling0.30
    4Lymphocyte Signaling
    Lymphocyte Signaling


    Find genes that share SuperPaths with PTPN22           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PTPN22
        CTLA4 Signaling
    Epithelial Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for PTPN22
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for PTPN22
        Anandamide biosynthesis and metabolism


        Pathway & Disease-focused RT2 Profiler PCR Array including PTPN22: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPN22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTPN22 (Q9Y2R21, 2, 3 ENSP000003528334) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD247P209631, 3, ENSP000003547824EBI-1211241,EBI-1165705 I2D: score=3 STRING: ENSP00000354782
    LCKP062391, 3, ENSP000003378254EBI-1211241,EBI-1348 I2D: score=3 STRING: ENSP00000337825
    ZAP70P434031, 3, ENSP000002649724EBI-1211241,EBI-1211276 I2D: score=3 STRING: ENSP00000264972
    GRB2P629931, 2, 3, ENSP000003390074EBI-1211241,EBI-401755 MINT-7033943 MINT-7033873 I2D: score=4 STRING: ENSP00000339007
    CBLP226812, 3, ENSP000002640334MINT-8215437 MINT-8215446 I2D: score=1 STRING: ENSP00000264033
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS--
    GO:0016311dephosphorylation ----
    GO:0030217T cell differentiation ISS--
    GO:0032817regulation of natural killer cell proliferation IDA--
    GO:0035335peptidyl-tyrosine dephosphorylation IDA10068674

    Find genes that share ontologies with PTPN22           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPN22 (PTN22)

    2 HMDB Compounds for PTPN22    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 Novoseek inferred chemical compound relationships for PTPN22 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 77.5 152 10068674 (2), 16461343 (2), 15531553 (2), 16015369 (2) (see all 86)
    arginine 0 2 15531553 (1), 16279843 (1)
    glutamate 0 2 19290936 (1)



    Find genes that share compounds with PTPN22           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PTPN22 gene (3 alternative transcripts): 
    NM_001193431.1  NM_012411.4  NM_015967.5  

    Unigene Cluster for PTPN22:

    Protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
    Hs.535276  [show with all ESTs]
    Unigene Representative Sequence: NM_015967
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460620 ENST00000359785(uc001eds.3 uc021orx.1 uc009wgq.3 uc021ory.1 uc010owo.2 uc001edt.3)
    ENST00000528414 ENST00000469077 ENST00000532224 ENST00000420377(uc009wgr.2 uc009wgs.2)
    ENST00000525799 ENST00000484147(uc001edu.2) ENST00000534519 ENST00000529045
    ENST00000538253
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PTPN22 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PTPN22:
    hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidPTPN22 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PTPN22
    Predesigned siRNA for gene silencing in human, mouse, rat PTPN22
    Clone
    Products:
         
    OriGene clones in human, mouse for PTPN22 (see all 15)
    OriGene ORF clones in mouse, rat for PTPN22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PTPN22 (NM_015967)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN22
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PTPN22
    OriGene qSTAR qPCR primer pairs in human, mouse for PTPN22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPN22
      QuantiTect SYBR Green Assays in human, mouse, rat PTPN22
      QuantiFast Probe-based Assays in human, mouse, rat PTPN22

    Additional mRNA sequence: 

    AF001846.1 AF077031.1 AK303124.1 AK310570.1 AK310698.1 BC017785.1 BC071670.1 GU479452.1 
    JN084012.1 U69700.1 

    8 DOTS entries:

    DT.206623  DT.99981204  DT.207269  DT.91759255  DT.95365499  DT.86858234  DT.100747078  DT.99940287 

    Selected AceView cDNA sequences (see all 50):

    AL597518 AA298761 BM458477 AA906845 AW576125 BX482744 AA748329 BC071670 
    AW504119 NM_015967 BX099228 BC017785 BU928431 BE241812 BU198510 BG536550 
    BG498752 BG219901 AF001846 AV705592 NM_012411 BG198463 AW665758 BG614041 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN22    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                          -                                                     -     -                                   -                                 
    SP2:                          -                                                                                               -                                 
    SP3:                          -                                                                                                                                 
    SP4:                          -                             -           -     -     -     -     -     -     -     -     -     -     -     -     -               
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for PTPN22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PTPN22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTPN22 Expression
    About this image


    PTPN22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Cumulus Cells Antral Follicle
             Oviduct
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    PTPN22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPN22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535276

    UniProtKB/Swiss-Prot: PTN22_HUMAN, Q9Y2R2
    Tissue specificity: Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes
    and both mature B and T-cells

        Pathway & Disease-focused RT2 Profiler PCR Array including PTPN22: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PTPN22
    OriGene qSTAR qPCR primer pairs in human, mouse for PTPN22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPN22
    QuantiTect SYBR Green Assays in human, mouse, rat PTPN22
    QuantiFast Probe-based Assays in human, mouse, rat PTPN22
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PTPN22 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn221 , 5 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) less1, 5 79.95(n)1
    71.8(a)1
      3 (45.52 cM)5
    192601  NM_008979.21  NP_033005.11 
     1038597955 
    chicken
    (Gallus gallus)
    Aves PTPN221 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) less 59.5(n)
    53.46(a)
      772032  XM_001235233.3  XP_001235234.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN226
    protein tyrosine phosphatase, non-receptor type 22...
    42(a)
    1 ↔ 1
    4(139233222-139278542)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ptpn221 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) less 54.03(n)
    45.39(a)
      100495002  XM_002932131.2  XP_002932177.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ptpn226
    protein tyrosine phosphatase, non-receptor type 22...
    30(a)
    1 ↔ 1
    23(26429952-26463417) ENSDARG00000075062
    worm
    (Caenorhabditis elegans)
    Secernentea T22C1.83 tyrosine specific protein phosphatase 34(a)
    (best of 4)
      I(7964118-7966380)   --


    ENSEMBL Gene Tree for PTPN22 (if available)
    TreeFam Gene Tree for PTPN22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PTPN22 gene
    PTPN12  PTPN112  PTPN92  PTPN62  PTPRN22  PTPRN2  PTPN142  PTPN212  
    PTPN20B2  PTPN22  PTPN122  PTPN182  PTPN20A2  
    Selected SIMAP similar genes for PTPN22 using alignment to 7 protein entries:     PTN22_HUMAN (see all proteins) (see all similar genes):
    PTP    ABI2    BEAN1    HINFP    PUS1    PFKFB3
    NELFA    TUBA1C    ARIH1    RQCD1    TNNT1    ATF1
    EEF1E1    EIF3G    NDC80    NLN    NLRC5    PTPN18

    Find genes that share paralogs with PTPN22           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PTPN22 (see all 1061)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24766011,2,,4
    C,F,Hother1114446512(+) TGTCCG/ATACAG 6 /R /W mis1 ese326Minor allele frequency- A:0.06NS EA NA WA CSA EU 8180
    rs715787921,2
    C--112228925(+) GCAGA-/TTTTTT 3 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs715787951,2
    C,F--112244051(+) CAAAA-/TG/   
      TGTGTG
    TGTGT
    6 -- int1 cds12NA CSA 4
    rs345783331,2
    C--112248019(+) TTTTT-/TGATGA 3 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs57771681,2
    C--112248994(+) ttttt-/Tttgga 3 -- int1 trp32Minor allele frequency- T:0.25NA CSA 4
    rs1130294101,2
    C--112250352(+) TTATT-/TATTTAT 3 -- int11Minor allele frequency- TA:0.00CSA 2
    rs1997114881,2
    --112250353(+) ATTTA-/TTTTAT 3 -- int10--------
    rs668473261,2
    C--112264670(+) TATATT/ATATAT 3 -- int11Minor allele frequency- A:0.50NA 2
    rs3692805191,2
    C--112264670(+) tatat-/A/A   
       T
    /ATA
    tattt
    6 -- int1 cds11NA 2
    rs354026891,2
    C--112266163(+) TGGGT-/AAAAAT 3 -- int12Minor allele frequency- A:0.00NA CSA 4

    HapMap Linkage Disequilibrium report for PTPN22 (114356433 - 114414381 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PTPN22:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv23869CNV Loss19812545
    nsv831093CNV Loss17160897

    Human Gene Mutation Database (HGMD): PTPN22
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTPN22
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPN22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600716   
    OMIM disorders: 222100  180300  152700  
    UniProtKB/Swiss-Prot: PTN22_HUMAN, Q9Y2R2
  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile
    multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints,
    kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory
    mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated
    erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • 17 diseases for PTPN22:    
    About MalaCards
    rheumatoid arthritis    temporal arteritis    vogt-koyanagi-harada disease    systemic lupus erythematosus
    palindromic rheumatism    pediatric systemic lupus erythematosus    graves' disease    wegener's granulomatosis
    type 1 diabetes mellitus    multifocal motor neuropathy    lupus erythematosus    vitiligo
    lymphopenia    polyarticular onset juvenile idiopathic arthritis    oligoarticular juvenile arthritis    meniere's disease
    arthritis

    7 diseases from the University of Copenhagen DISEASES database for PTPN22:
    Rheumatoid arthritis     Hypersensitivity reaction type II disease     Connective tissue disease     Hyperthyroidism
    Diabetes mellitus     Thyroiditis     Addison's disease

    Find genes that share disorders with PTPN22           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PTPN22 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 82.8 88 18056643 (3), 16731003 (2), 16690758 (2), 20166877 (2) (see all 57)
    autoimmune thyroid disease 81.6 7 19343596 (1), 19090780 (1), 18687223 (1), 16052563 (1)
    autoimmunity 79.4 39 17237219 (2), 18981062 (2), 19210888 (2), 16731003 (1) (see all 27)
    hashimotos thyroiditis 76.3 2 15719322 (1), 16320352 (1)
    addisons disease 75.9 11 18710467 (2), 16273109 (1), 18301444 (1), 19209622 (1) (see all 5)
    graves disease 75.2 13 15531553 (2), 18578611 (2), 17729039 (1), 17608818 (1) (see all 7)
    rheumatoid arthritis 68.9 51 18466483 (3), 18466461 (2), 15641066 (2), 17661906 (2) (see all 32)
    lupus erythematosus systemic 62.5 20 18981062 (2), 15641066 (2), 17729039 (1), 17868256 (1) (see all 12)
    vitiligo 61.9 16 18426414 (2), 16015369 (2), 17729039 (1), 19209622 (1) (see all 6)
    genetic susceptibility 56.3 8 18301444 (2), 19503742 (1), 19343596 (1), 16164701 (1) (see all 6)

    Genetic Association Database (GAD): PTPN22
    Human Genome Epidemiology (HuGE) Navigator: PTPN22 (268 documents)

    Export disorders for PTPN22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PTPN22 gene, integrated from 10 sources (see all 416):
    (articles sorted by number of sources associating them with PTPN22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. (PubMed id 10068674)1, 2, 3, 9 Cohen S.... Roifman C.M. (Blood 1999)
    2. Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. (PubMed id 15273934)1, 2, 4 Kyogoku C.... Behrens T.W. (Am. J. Hum. Genet. 2004)
    3. Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid- specific tyrosine phosphatase implicated in autoimmune diseases. (PubMed id 18056643)1, 2, 9 Yu X....Zhang Z.Y. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    4. The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1. (PubMed id 16052172)1, 4, 9 Reddy M.V....AlarcA^n-Riquelme M.E. (Genes Immun. 2005)
    5. Associations of protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene polymorphisms with susceptibility to Graves' disease in a Japanese population. (PubMed id 18578611)1, 4, 9 Ichimura M....Hiromatsu Y. (Thyroid 2008)
    6. Identification of substrates of human protein-tyrosine phosphatase PTPN22. (PubMed id 16461343)1, 2, 9 Wu J....Clark J.M. (J. Biol. Chem. 2006)
    7. Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population. (PubMed id 16690758)1, 4, 9 Ikari K....Kamatani N. (Rheumatology (Oxford) 2006)
    8. PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. (PubMed id 16175503)1, 4, 9 Carlton V.E....Begovich A.B. (Am. J. Hum. Genet. 2005)
    9. [Association of polymorphism of protein tyrosine phosphatase nonreceptor-22 gene with AITD]. (PubMed id 18687223)1, 4, 9 Yu Z.Y....Dong B.N. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008)
    10. Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations. (PubMed id 16470599)1, 4, 9 Kawasaki E....Eguchi K. (Am. J. Med. Genet. A 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26191 HGNC: 9652 AceView: PTPN22 Ensembl:ENSG00000134242 euGenes: HUgn26191
    ECgene: PTPN22 H-InvDB: PTPN22

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PTPN22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PTPN22 gene:
    Search GeneIP for patents involving PTPN22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for PTPN22 (Lyp)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PTPN22   OriGene RNAi products in human, mouse, rat for PTPN22  
     OriGene qPCR primer pairs and template standards for PTPN22   OriGene Protein Over-expression Lysate for PTPN22  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PTPN22  
     OriGene qSTAR qPCR primer pairs in human, mouse for PTPN22   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PTPN22   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PTPN22   OriGene Custom Protein Services for PTPN22  

     
     
     Block miRNA regulation of human, mouse, rat PTPN22 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PTPN22
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN22 Predesigned siRNA for gene silencing in human, mouse, rat PTPN22
     QuantiFast Probe-based Assays in human, mouse, rat PTPN22 QuantiTect SYBR Green Assays in human, mouse, rat PTPN22
     PCR Arrays including human, mouse, rat PTPN22 Search Chromatin IP Primers for PTPN22
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPN22  GeneGlobe Interaction Network for PTPN22
     Regulatory tfbs in PTPN22 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PTPN22 GenScript cDNA clones with any tag delivered in your preferred vector for PTPN22
     GenScript Custom Assay Services for PTPN22 GenScript Custom overexpressing Cell Line Services for PTPN22
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for PTPN22 

     Search Tocris compounds for PTPN22 (PTN22)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PTPN22 antibodies
     PTPN22 proteins
     PTPN22 lysates
     Antibodies for PTPN22
     See all of Abcam's Antibodies, Kits and Proteins for PTPN22
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PTPN22
     Antibodies for PTPN22
     ELISAs for PTPN22
     CLIAs for PTPN22



     Browse ESI BIO Cell Lines and PureStem Progenitors for PTPN22
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN22
     SwitchGear 3'UTR luciferase reporter plasmids for PTPN22
     SwitchGear Promoter luciferase reporter plasmids for PTPN22
     ThermoFisher Antibodies for PTPN22
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN22
     Browse compounds at ApexBio
     Search Addgene for plasmids for PTPN22
      Search eBioscience for proteins for PTPN22
      Search eBioscience for elisas for PTPN22
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PTPN22
     antibodies-online antibodies for PTPN22 (37 products)
     antibodies-online kits for PTPN22 (4 products)
     antibodies-online peptides for PTPN22
     antibodies-online proteins for PTPN22 (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PTPN22 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4