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Aliases for PTPN21 Gene

Aliases for PTPN21 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 21 2 3
  • PTPD1 3 4 6
  • Protein-Tyrosine Phosphatase D1 3 4
  • EC 4 63
  • DJ1175B15.2 (Protein Tyrosine Phosphatase, Non-Receptor Type 21) 3
  • Tyrosine-Protein Phosphatase Non-Receptor Type 21 3
  • Protein Tyrosine Phosphatase D1 3
  • EC 3.1.3 63
  • PTPRL10 3

External Ids for PTPN21 Gene

Previous GeneCards Identifiers for PTPN21 Gene

  • GC14M086439
  • GC14M082750
  • GC14M086924
  • GC14M088003
  • GC14M088932
  • GC14M069102

Summaries for PTPN21 Gene

Entrez Gene Summary for PTPN21 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPN21 Gene

PTPN21 (Protein Tyrosine Phosphatase, Non-Receptor Type 21) is a Protein Coding gene. Among its related pathways are PAK Pathway and Signaling events mediated by focal adhesion kinase. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is PTPN6.

Gene Wiki entry for PTPN21 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN21 Gene

Genomics for PTPN21 Gene

Regulatory Elements for PTPN21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPN21 Gene

88,465,778 bp from pter
88,554,779 bp from pter
89,002 bases
Minus strand

Genomic View for PTPN21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN21 Gene

Proteins for PTPN21 Gene

  • Protein details for PTPN21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 21
    Protein Accession:
    Secondary Accessions:

    Protein attributes for PTPN21 Gene

    1174 amino acids
    Molecular mass:
    133281 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PTPN21 Gene

Proteomics data for PTPN21 Gene at MOPED

Post-translational modifications for PTPN21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPN21 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PTPN21

Domains for PTPN21 Gene

Gene Families for PTPN21 Gene

Suggested Antigen Peptide Sequences for PTPN21 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FERM domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
  • Contains 1 FERM domain.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with PTPN21: view

Function for PTPN21 Gene

Molecular function for PTPN21 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,non-receptor type 21,widely expressed
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

Enzyme Numbers (IUBMB) for PTPN21 Gene

Gene Ontology (GO) - Molecular Function for PTPN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 15143158
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPN21: view

Phenotypes for PTPN21 Gene

GenomeRNAi human phenotypes for PTPN21:
genes like me logo Genes that share phenotypes with PTPN21: view

Animal Model Products

miRNA for PTPN21 Gene

miRTarBase miRNAs that target PTPN21

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN21

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PTPN21 Gene

Localization for PTPN21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN21 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for PTPN21 Gene COMPARTMENTS Subcellular localization image for PTPN21 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
mitochondrion 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for PTPN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with PTPN21: view

Pathways for PTPN21 Gene

genes like me logo Genes that share pathways with PTPN21: view

Pathways by source for PTPN21 Gene

1 Qiagen pathway for PTPN21 Gene
1 BioSystems pathway for PTPN21 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 7519780
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 7519780
genes like me logo Genes that share ontologies with PTPN21: view

Drugs for PTPN21 Gene

(3) HMDB Compounds for PTPN21 Gene

Compound Synonyms Cas Number PubMed IDs
  • NFB Orthophosphate
Phosphoric acid
  • Acide phosphorique (FRENCH)
  • Dihydrogen oxide
genes like me logo Genes that share compounds with PTPN21: view

Transcripts for PTPN21 Gene

Unigene Clusters for PTPN21 Gene

Protein tyrosine phosphatase, non-receptor type 21:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN21 Gene

No ASD Table

Relevant External Links for PTPN21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPN21 Gene

mRNA expression in normal human tissues for PTPN21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PTPN21 Gene

This gene is overexpressed in Pancreatic juice (55.6) and Placenta (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN21 Gene

SOURCE GeneReport for Unigene cluster for PTPN21 Gene Hs.437040

genes like me logo Genes that share expressions with PTPN21: view

Expression partners for PTPN21 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTPN21 Gene

Orthologs for PTPN21 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN21 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PTPN21 35
  • 83.75 (n)
  • 88.01 (a)
PTPN21 36
  • 83 (a)
(Canis familiaris)
Mammalia PTPN21 35
  • 86.92 (n)
  • 89.74 (a)
PTPN21 36
  • 90 (a)
(Mus musculus)
Mammalia Ptpn21 35
  • 83.73 (n)
  • 89.08 (a)
Ptpn21 16
Ptpn21 36
  • 89 (a)
(Pan troglodytes)
Mammalia PTPN21 35
  • 99.23 (n)
  • 99.15 (a)
PTPN21 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ptpn21 35
  • 82.48 (n)
  • 88.16 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
-- 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
-- 36
  • 83 (a)
(Gallus gallus)
Aves PTPN21 35
  • 76.18 (n)
  • 85.51 (a)
PTPN21 36
  • 83 (a)
(Anolis carolinensis)
Reptilia PTPN21 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn21 35
  • 71.69 (n)
  • 79.52 (a)
Str.19434 35
(Danio rerio)
Actinopterygii Dr.19765 35
ptpn21 35
  • 70.62 (n)
  • 75.31 (a)
ptpn21 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pez 37
  • 38 (a)
Pez 36
  • 27 (a)
Species with no ortholog for PTPN21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTPN21 Gene

Gene Tree for PTPN21 (if available)
Gene Tree for PTPN21 (if available)

Paralogs for PTPN21 Gene

genes like me logo Genes that share paralogs with PTPN21: view

Variants for PTPN21 Gene

Sequence variations from dbSNP and Humsavar for PTPN21 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs765055 -- 88,554,141(+) TTTCT(C/T)AGCAA intron-variant
rs816067 -- 88,503,044(-) aaGAT(C/T)TAGTT intron-variant
rs816068 -- 88,502,324(+) ctcac(C/T)tgtgg intron-variant
rs816069 -- 88,500,992(-) TTCCT(G/T)AATAG intron-variant
rs816070 -- 88,499,734(-) CACTT(C/G/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPN21 Gene

Variant ID Type Subtype PubMed ID
nsv456391 CNV Gain 19166990
esv272216 CNV Insertion 20981092
nsv516846 CNV Gain 19592680
nsv902181 CNV Gain 21882294

Relevant External Links for PTPN21 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN21 Gene

Disorders for PTPN21 Gene

Relevant External Links for PTPN21

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PTPN21 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PTPN21 Gene

Publications for PTPN21 Gene

  1. Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain. (PMID: 7519780) Moeller N.P.H. … Ullrich A. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4
  2. Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. (PMID: 16918960) Zeitlin A.A. … Simmonds M.J. (Clin. Endocrinol. (Oxf) 2006) 3 48
  3. Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability. (PMID: 19000305) Korff S. … Gebert J. (BMC Cancer 2008) 3 48
  4. Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1. (PMID: 7838537) Higashitsuji H. … Fujita J. (Oncogene 1995) 3 23
  5. Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. (PMID: 15143158) Cardone L. … Feliciello A. (Mol. Cell. Biol. 2004) 3 23

Products for PTPN21 Gene

Sources for PTPN21 Gene

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