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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPN21 Gene

protein-coding   GIFtS: 63
GCID: GC14M088932

Protein Tyrosine Phosphatase, Non-Receptor Type 21

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 211 2     DJ1175B15.2 (Protein Tyrosine Phosphatase, Non-Receptor Type 21)2
Protein-Tyrosine Phosphatase D12 3     Protein Tyrosine Phosphatase D12
PTPD12 3     Tyrosine-Protein Phosphatase Non-Receptor Type 212
EC 3.1.3.483 8     EC 3.1.38
PTPRL102     

External Ids:    HGNC: 96511   Entrez Gene: 110992   Ensembl: ENSG000000707787   OMIM: 6032715   UniProtKB: Q168253   

Export aliases for PTPN21 gene to outside databases

Previous GC identifers: GC14M086439 GC14M082750 GC14M086924 GC14M088003 GC14M069102


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPN21 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal-
associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with
BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and
SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not
STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration
and spermatogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTPN21 Gene: 
PTPN21 (protein tyrosine phosphatase, non-receptor type 21) is a protein-coding gene. Diseases associated with PTPN21 include graves' disease, and among its related super-pathways are PAK Pathway. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is FRMD1.

Gene Wiki entry for PTPN21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPN21 gene promoter:
         STAT5B   Max1   RP58   AP-1   ATF-2   Lmo2   Tal-1beta   AREB6   c-Jun   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN21 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPN21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31.3   Ensembl cytogenetic band:  14q31.3   HGNC cytogenetic band: 14q31

PTPN21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN21 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M088932:  view genomic region     (about GC identifiers)

Start:
88,932,122 bp from pter      End:
89,021,123 bp from pter
Size:
89,002 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTN21_HUMAN, Q16825 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 21  
Size: 1174 amino acids; 133281 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)

Explore the universe of human proteins at neXtProt for PTPN21: NX_Q16825

Explore proteomics data for PTPN21 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16825

  • 4/14 DME Specific Peptides for PTPN21 (Q16825) (see all 14)
     YIATQGP  EGLPPLG  CYATTGLK  TRYQYYLQ 

    PTPN21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTPN21 Protein Expression
    REFSEQ proteins: NP_008970.2  
    ENSEMBL proteins: 
     ENSP00000452414   ENSP00000450847   ENSP00000443951   ENSP00000451401   ENSP00000330276  

    Human Recombinant Protein Products for PTPN21: 
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    Cloud-Clone Corp. Proteins for PTPN21 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--

    PTPN21 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    5/13 InterPro protein domains (see all 13):
     IPR019748 FERM_central
     IPR019750 Band_41_fam
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR019747 FERM_CS

    Graphical View of Domain Structure for InterPro Entry Q16825

    ProtoNet protein and cluster: Q16825

    2 Blocks protein domains:
    IPB000242 Protein tyrosine phosphatase signature
    IPB000299 Band 4.1 domain


    UniProtKB/Swiss-Prot: PTN21_HUMAN, Q16825
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    PTPN21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN21_HUMAN, Q16825
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN21:
    protein tyrosine phosphatase,non-receptor type 21,widely expressed

         Enzyme Numbers (IUBMB): EC 3.1.3.481 2 EC 3.1.32

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI15143158
    GO:0016791phosphatase activity ----
         
    PTPN21 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PTPN21:
     Decreased focal adhesion (FA)  

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPN21 
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    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN21 (see all 49):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-607 hsa-miR-3607-3p hsa-miR-3655 hsa-miR-429 hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidPTPN21 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTPN21 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2Signaling events mediated by focal adhesion kinase
    Signaling events mediated by focal adhesion kinase

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPN21
        Epithelial Adherens Junctions

    1 BioSystems Pathway for PTPN21
        Signaling events mediated by focal adhesion kinase


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/12 Interacting proteins for PTPN21 (Q168252, 3 ENSP000003302764) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRCP129312, 3, ENSP000003509414MINT-8213996 MINT-8213987 MINT-8214153 I2D: score=3 STRING: ENSP00000350941
    KIF1CO438963, ENSP000003208214I2D: score=2 STRING: ENSP00000320821
    TECP426803, ENSP000003709124I2D: score=1 STRING: ENSP00000370912
    AKAP1Q926673, ENSP000003377364I2D: score=1 STRING: ENSP00000337736
    BMXP518133, ENSP000003087744I2D: score=2 STRING: ENSP00000308774
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS7519780
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS7519780

    PTPN21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPN21 (PTN21)

    2 HMDB Compounds for PTPN21    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about PTPN21 / PTN21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTPN21 gene: 
    NM_007039.3  

    Unigene Cluster for PTPN21:

    Protein tyrosine phosphatase, non-receptor type 21
    Hs.437040  [show with all ESTs]
    Unigene Representative Sequence: NM_007039
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556564(uc001xwv.4) ENST00000553531 ENST00000536337 ENST00000554270
    ENST00000557249 ENST00000554628(uc010atf.1) ENST00000555243 ENST00000554178
    ENST00000328736(uc010twc.2)
    miRNA
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    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-607 hsa-miR-3607-3p hsa-miR-3655 hsa-miR-429 hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidPTPN21 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN21

    Additional mRNA sequence: 

    AK310480.1 BC143846.1 BC143847.1 X79510.1 

    6 DOTS entries:

    DT.114004  DT.114461  DT.91727335  DT.97838008  DT.40131494  DT.75103158 

    24/155 AceView cDNA sequences (see all 155):

    AI207296 AA501995 BM990024 H88364 AA099184 AA256693 BG055463 BE326276 
    AA507919 AA910386 AA421778 AI418731 BX092903 BG110359 CA449053 BE161786 
    AI470459 H03614 BU838545 BQ009562 CR593033 AL045676 H88426 H88413 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPN21 expression in normal human tissues (normalized intensities)      PTPN21 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTTTAAA
    PTPN21 Expression
    About this image


    PTPN21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             oocyte   
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain

     -- (Integumentary System)
             skin   

    See PTPN21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPN21

    SOURCE GeneReport for Unigene cluster: Hs.437040
        SABiosciences Expression via Pathway-Focused PCR Array including PTPN21: 
              Protein Phosphatases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PTPN21 gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn211 , 5 protein tyrosine phosphatase, non-receptor type 211, 5 83.96(n)1
    89.42(a)1
      12 (49.88 cM)5
    240001  NM_011877.21  NP_036007.21 
     986767415 
    chicken
    (Gallus gallus)
    Aves PTPN211 protein tyrosine phosphatase, non-receptor type 21 76.18(n)
    85.51(a)
      423398  XM_421308.3  XP_421308.3 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN216
    protein tyrosine phosphatase, non-receptor type 21...
    81(a)
    1 ↔ 1
    1(13604515-13658324)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.194342 Transcribed sequence with moderate similarity to protein more 79.78(n)    142003161 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.197652 Transcribed sequence with moderate similarity to protein more 76.41(n)    AL914295.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pez3 protein amino acid dephosphorylation
    protein tyrosine more
    38(a)   26C3   --
    worm
    (Caenorhabditis elegans)
    Secernentea egg-56
    egg-46
    Protein EGG-4
    13(a)
    13(a)
    many ↔ many
    many ↔ many
    I(4168987-4171589)
    I(3932210-3934814)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PTP16
    Phosphotyrosine-specific protein phosphatase that ...
    28(a)
    1 → many
    IV(42700-43707)


    ENSEMBL Gene Tree for PTPN21 (if available)
    TreeFam Gene Tree for PTPN21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPN21 gene
    FRMD12  PTPN142  PTPN20B2  FRMPD22  FRMD62  PTPN132  PTPN20A2  
    16 SIMAP similar genes for PTPN21 using alignment to 5 protein entries:     PTN21_HUMAN (see all proteins):
    PTPN14    BPTP-2    EPB41L4A    PTPN4    PTPRR    FRMD4B
    BPTP-3    FARP1    EPB41L3    FRMPD2    EPB41L2    PTPN5
    FARP2    EPB41L1    PTPN20A    PTPN20B

    PTPN21 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2074 SNPs in PTPN21 are shown (see all 2074)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1414959231,2
    --88931627(+) CCAACA/GTGGTG 1 -- ds50010--------
    rs1424186111,2
    --88931689(+) GCCTGC/TAATCC 1 -- ds50010--------
    rs1433052051,2
    --88931792(+) GGCAAC/TAGAGC 1 -- ds50010--------
    rs101299171,2
    C,F,A,H--88931805(+) GACTCC/TGTCTC 1 -- ds50015Minor allele frequency- T:0.36NA 14
    rs1865453021,2
    --88931878(+) CATCAA/GAAGAC 1 -- ds50010--------
    rs1493468361,2
    C--88931889(+) CCACT-/AATC  
            
    AATCA
    1 -- ds50010--------
    rs1898787321,2
    --88931890(+) CCACTA/GATCAG 1 -- ds50010--------
    rs1415253891,2
    --88931942(+) CAGTGA/GTTTAT 1 -- ds50010--------
    rs1812384881,2
    --88931955(+) CTCTAC/TGTTTT 1 -- ds50010--------
    rs740726251,2
    C,F--88931986(+) AATTCT/GTATTA 1 -- ds50013Minor allele frequency- G:0.16WA 122

    HapMap Linkage Disequilibrium report for PTPN21 (88932122 - 89021123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PTPN21:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv272216CNV Insertion20981092
    nsv902181CNV Gain21882294
    nsv516846CNV Gain19592680
    nsv456391CNV Gain19166990


    Human Gene Mutation Database (HGMD): PTPN21
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603271    OMIM disorders: --

    2 diseases for PTPN21:    About MalaCards
    graves' disease    


    PTPN21 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PTPN21
    Human Genome Epidemiology (HuGE) Navigator: PTPN21 (3 documents)

    Export disorders for PTPN21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPN21 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with PTPN21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain. (PubMed id 7519780)1, 2, 3 Moeller N.P.H....Ullrich A. (1994)
    2. Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability. (PubMed id 19000305)1, 4 Korff S....Gebert J. (2008)
    3. Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. (PubMed id 16918960)1, 4 Zeitlin A.A....Simmonds M.J. (2006)
    4. Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration. (PubMed id 18223254)1, 9 Carlucci A....Feliciello A. (2008)
    5. Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1. (PubMed id 7838537)1, 9 Higashitsuji H....Fujita J. (1995)
    6. Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. (PubMed id 15143158)1, 9 Cardone L....Feliciello A. (2004)
    7. Two non-synonymous markers in PTPN21, identified by g enome-wide association study data-mining and replication, are associated with s chizophrenia. (PubMed id 21752600)1 Chen J....Chen X. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    10. PTPD1 supports receptor stability and mitogenic signa ling in bladder cancer cells. (PubMed id 20923765)1 Carlucci A....Feliciello A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11099 HGNC: 9651 AceView: PTPN21 Ensembl:ENSG00000070778 euGenes: HUgn11099
    ECgene: PTPN21 H-InvDB: PTPN21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPN21 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN21 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTPN21 gene:
    Search GeneIP for patents involving PTPN21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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