PTPN21 Gene
protein-coding GIFtS: 60
GCID: GC14M088932
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protein tyrosine phosphatase, non-receptor type 21
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Aliases for PTPN21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Protein Tyrosine Phosphatase, Non-Receptor Type 211 2 | | DJ1175B15.2 (Protein Tyrosine Phosphatase, Non-Receptor Type 21)2 | | PTPD11 2 3 | | Protein Tyrosine Phosphatase D12 | | PTPRL101 2 | | Tyrosine-Protein Phosphatase Non-Receptor Type 212 | | Protein-Tyrosine Phosphatase D12 3 | | EC 3.1.38 | | EC 3.1.3.483 8 | | |
Export aliases for PTPN21 gene to outside databasesPrevious GC identifers: GC14M086439 GC14M082750 GC14M086924 GC14M088003 GC14M069102 |
Summaries for PTPN21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for PTPN21: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitoticcycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associatedproteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, amember of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains.The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase.Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration andspermatogenesis. (provided by RefSeq, Jul 2008) Gene Wiki entry for PTPN21
|
Genomic Views for PTPN21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PTPN21 gene promoter: STAT5B Max1 RP58 AP-1 ATF-2 Lmo2 Tal-1beta AREB6 c-Jun ITF-2 Other transcription factors
Search SABiosciences Chromatin IP Primers for PTPN21
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN21 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q31.3 Ensembl cytogenetic band: 14q31.3 HGNC cytogenetic band: 14q31PTPN21 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M088932: view genomic region
(about GC identifiers)
Start:
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88,932,122 bp from pter |
End:
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89,021,123 bp from pter |
Size:
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89,002 bases |
Orientation:
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minus strand |
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Proteins for PTPN21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: PTN21_HUMAN, Q16825 (See
protein sequence)Recommended Name: Tyrosine-protein phosphatase non-receptor type 21 Size: 1174 amino acids; 133281 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)Explore the universe of human proteins at neXtProt for PTPN21: NX_Q16825
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16825 4/14 DME Specific Peptides for PTPN21 (Q16825) (see all 14)
PTPN21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008970.2 ENSEMBL proteins: ENSP00000452414 ENSP00000450847 ENSP00000443951 ENSP00000451401 ENSP00000330276 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PTPN21 for ontologies About GeneDecksing
PTPN21 Antibody Products: Assay Products for PTPN21: |
Protein
Domains / Families for PTPN21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PTPN21 for domains About GeneDecksing
5/13 InterPro domains/families (see all 13):Graphical View of Domain Structure for InterPro Entry Q16825ProtoNet protein and cluster: Q16825 2 Blocks protein families: IPB000242 Protein tyrosine phosphatase signature IPB000299 Band 4.1 domain
UniProtKB/Swiss-Prot: PTN21_HUMAN, Q16825Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamilySimilarity: Contains 1 FERM domainSimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function for PTPN21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: PTN21_HUMAN, Q16825Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate Genatlas biochemistry entry for PTPN21:protein tyrosine phosphatase,non-receptor type 21,widely expressed Enzyme Numbers (IUBMB): EC 3.1.3.481 2 EC 3.1.32
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN21 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN21 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PTPN21 (NM_007039) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN21 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004725 | protein tyrosine phosphatase activity |
IEA | -- |
PTPN21 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PTPN21:
|
Pathways & Interactions for PTPN21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling events mediated by focal adhesion kinase | | | 2 | PAK Pathway | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPN21 1 BioSystems Pathway for PTPN21 
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN21
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
 5/12 Interacting proteins for PTPN21 (Q168252, 3 ENSP000003302764) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
PTPN21 for ontologies About GeneDecksing
|
Drugs & Compounds for PTPN21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for PTPN21
2 HMDB Compounds for PTPN21 About this table Search CenterWatch for drugs/clinical trials and news about PTPN21 / PTN21 
|
Transcripts for PTPN21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for PTPN21 gene: NM_007039.3 Unigene Cluster for PTPN21: Protein tyrosine phosphatase, non-receptor type 21 Hs.437040 [show with all ESTs]Unigene Representative Sequence: NM_0070399 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000556564(uc001xwv.4) ENST00000553531 ENST00000536337 ENST00000554270 ENST00000557249 ENST00000554628(uc010atf.1) ENST00000555243 ENST00000554178 ENST00000328736(uc010twc.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN21 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN21 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PTPN21 (NM_007039) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTPN21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN21  |
Additional cDNA sequence: AK310480.1 BC143846.1 BC143847.1 X79510.1 6 DOTS entries: DT.114004 DT.114461 DT.91727335 DT.97838008 DT.40131494 DT.75103158 24/155 AceView cDNA sequences (see all 155): AI207296 H88426 AA421778 CR593033 BG110359 AA910386 AA099184 AL045676 BE161786 AW298324 AA507919 H03614 BU838545 BX092903 H88413 AA256693 BM990024 H88364 BE326276 N71987 AI470459 BQ009562 AI418731 CA449053 GeneLoc Exon Structure
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Expression for PTPN21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PTPN21 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TAATTTTAAA
About this image See PTPN21 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PTPN21
SOURCE GeneReport for Unigene cluster: Hs.437040 SABiosciences Expression via Pathway-Focused PCR Array including PTPN21:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN21 Browse OriGene validated miRNA SYBR primer pairs
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| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN21 |
Orthologs for PTPN21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PTPN21 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
PTPN211 |
protein tyrosine phosphatase, non-receptor type 21 |
76.18(n) 85.51(a) |
  |
423398 XM_421308.3 XP_421308.3 |
lizard (Anolis carolinensis) |
Reptilia |
PTPN216 |
-- |
81(a) |
1 ↔ 1 |
1(13604515-13658324) |
tropical clawed frog (Xenopus tropicalis) |
Amphibia |
Str.194342 |
Transcribed sequence with moderate similarity to protein more |
79.78(n) |
  |
142003161 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.197652 |
Transcribed sequence with moderate similarity to protein more |
76.41(n) |
  |
AL914295.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
Pez3 |
protein amino acid dephosphorylation protein tyrosine more |
38(a) |
  |
26C3 -- |
ENSEMBL Gene Tree for PTPN21 (if available) TreeFam Gene Tree for PTPN21 (if available)  |
Paralogs for PTPN21 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for PTPN21 gene
- PTPN12 PTPN32 PTPN20C2 FRMPD22 PTPN42 PTPN132 PTPN92 PTPN142
- PTPN20B2 PTPN22 PTPN20A2
16 SIMAP similar genes for PTPN21 using alignment to 5 protein entries: PTN21_HUMAN (see all proteins):PTPN14 BPTP-2 EPB41L4A PTPN4 PTPRR FRMD4B BPTP-3 EPB41L3 FRMPD2 EPB41L2 PTPN5 FARP2 EPB41L1 PTPN20A PTPN20B DKFZp566K0524
PTPN21 for paralogs About GeneDecksing
|
Genomic Variants for PTPN21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 14 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for PTPN21 (88932122 - 89021123 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for PTPN21: -- Human Gene Mutation Database (HGMD): PTPN21
 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases for PTPN21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PTPN21 for disorders About GeneDecksing
OMIM gene information: 603271
OMIM disorders: --
1 disease for PTPN21: About MalaCardsgraves' disease Human Genome Epidemiology (HuGE) Navigator: PTPN21 (3 documents) Export disorders for PTPN21 gene to outside databases
|
Publications for PTPN21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PTPN21 gene, integrated from 9 sources (see all 16): (articles sorted by number of sources associating them with PTPN21) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain. (PubMed id 7519780)1, 2, 3 Moeller N.P.H....Ullrich A. (1994)
- Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration. (PubMed id 18223254)1, 9 Carlucci A....Feliciello A. (2008)
- Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1. (PubMed id 7838537)1, 9 Higashitsuji H....Fujita J. (1995)
- Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. (PubMed id 15143158)1, 9 Cardone L....Feliciello A. (2004)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Two non-synonymous markers in PTPN21, identified by g enome-wide association study data-mining and replication, are associated with s chizophrenia. (PubMed id 21752600)1 Chen J....Chen X. (2011)
- PTPD1 supports receptor stability and mitogenic signa ling in bladder cancer cells. (PubMed id 20923765)1 Carlucci A....Feliciello A. (2010)
- Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability. (PubMed id 19000305)1 Korff S....Gebert J. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. (PubMed id 16918960)1 Zeitlin A.A....Simmonds M.J. (2006)
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External Searches for PTPN21 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PTPN21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PTPN21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PTPN21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for PTPN21 gene: Search GeneIP for patents involving PTPN21
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for PTPN21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
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| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN21 |
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