Aliases for PTPN21 Gene
External Ids for PTPN21 Gene
Previous GeneCards Identifiers for PTPN21 Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPN21 Gene
PTPN21 (Protein Tyrosine Phosphatase, Non-Receptor Type 21) is a Protein Coding gene. Diseases associated with PTPN21 include gastric lymphoma. Among its related pathways are PAK Pathway and Signaling events mediated by focal adhesion kinase. GO annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is PTPN14.