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PTPN20B Gene

protein-coding   GIFtS: 42
GCID: GC10M048738

Protein Tyrosine Phosphatase, Non-Receptor Type 20B

  Search for PTPN20B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 20B1 2
EC 3.1.3.483 8
bA42B19.12
Protein Tyrosine Phosphatase, Non-Receptor Type 202
hPTPN203

External Ids:    HGNC: 234231   Entrez Gene: 260952   Ensembl: ENSG000001836757   OMIM: 6106315   UniProtKB: Q4JDL33   

Export aliases for PTPN20B gene to outside databases

Previous GC identifers: GC10U900463 GC10M048360 GC10M043590


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPN20B Gene:
The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many
protein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated
in human diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein
tyrosine phosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and
PTPN20B. A third copy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene
encodes the more telomeric copy, PTPN20B. Multiple alternatively spliced transcript variants encoding different
isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTPN20B Gene:
PTPN20B (protein tyrosine phosphatase, non-receptor type 20B) is a protein-coding gene. An important paralog of this gene is PTPN1.

UniProtKB/Swiss-Prot: PTN20_HUMAN, Q4JDL3
Function: Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied
extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPN20B gene promoter:
         MEF-2A   GR   AML1a   FOXC1   MEF-2   aMEF-2   GR-alpha   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN20B promoter sequence
   Search Chromatin IP Primers for PTPN20B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN20B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.22   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11.22

PTPN20B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN20B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M048738:  view genomic region     (about GC identifiers)

Start:
48,736,874 bp from pter      End:
48,827,966 bp from pter
Size:
91,093 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PTN20_HUMAN, Q4JDL3 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 20  
Size: 420 amino acids; 48423 Da
Sequence caution: Sequence=AAW28797.1; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: A6NNH8 B7ZKV3 Q4JDG6 Q4JDK1 Q4JDK5 Q4JDK6 Q4JDK8 Q4JDK9 Q4JDL0 Q4JDL1
Q4JDL4 Q4JDL5 Q4JDL6 Q4JDL7 Q4JDL8 Q5RJ33 Q5T1G3
Alternative splicing: 15 isoforms:  Q4JDL3-1   Q4JDL3-2   Q4JDL3-3   Q4JDL3-4   Q4JDL3-5   Q4JDL3-6   Q4JDL3-7   Q4JDL3-8   
Q4JDL3-9   Q4JDL3-10   Q4JDL3-11   Q4JDL3-12   Q4JDL3-13   Q4JDL3-14   Q4JDL3-15   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for PTPN20B: NX_Q4JDL3

Explore proteomics data for PTPN20B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for PTPN20B (Q4JDL3)
     VVHCSAG  YIATQGP  QRSGMVQT  HCSAGIGR 


    See PTPN20B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (10 alternative transcripts): 
    NP_001035816.1  NP_001035817.1  NP_001035818.1  NP_001035819.1  NP_001035820.1  NP_001035821.1  NP_001035822.1  NP_001035823.1  
    NP_001035824.1  NP_056420.3  

    ENSEMBL proteins: 
     ENSP00000473742   ENSP00000331832   ENSP00000363357   ENSP00000363350   ENSP00000425723  
     ENSP00000423839   ENSP00000427171   ENSP00000422953   ENSP00000424942   ENSP00000421604  
     ENSP00000424344   ENSP00000423545   ENSP00000421999   ENSP00000425285   ENSP00000426298  
     ENSP00000424728   ENSP00000379033   ENSP00000427588   ENSP00000406097   ENSP00000426605  
     ENSP00000427081   ENSP00000379020   ENSP00000363352   ENSP00000379021   ENSP00000379027  
     ENSP00000379022  

    PTPN20B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    3 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry Q4JDL3

    ProtoNet protein and cluster: Q4JDL3

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTN20_HUMAN, Q4JDL3
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPN20B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN20_HUMAN, Q4JDL3
    Function: Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied
    extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with PTPN20B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PTPN20B:
     Increased Akt phosphorylation  

         1 MGI phenotypic allele for Ptpn20 (no phenotypes)

    Find genes that share phenotypes with PTPN20B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTPN20B
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PTPN20B (see all 14):
    hsa-miR-3163 hsa-miR-3152-3p hsa-miR-3607-3p hsa-miR-4272 hsa-miR-1258 hsa-miR-944 hsa-miR-138-2* hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidPTPN20B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PTPN20B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTN20_HUMAN, Q4JDL3: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Note=Colocalizes with the microtubule-organizing center and intracellular membrane compartments
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005815microtubule organizing center ----
    GO:0005874microtubule ----

    Find genes that share ontologies with PTPN20B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PTPN20B
    Interactions:

        Search GeneGlobe Interaction Network for PTPN20B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for PTPN20B (ENSP000003633504) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K4ENSP000003759864STRING: ENSP00000375986
    PKMYT1ENSP000002623004STRING: ENSP00000262300
    WEE1ENSP000004020844STRING: ENSP00000402084
    WEE2ENSP000003806754STRING: ENSP00000380675
    MAP2K1ENSP000003024864STRING: ENSP00000302486
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation ----
    GO:0016311dephosphorylation ----

    Find genes that share ontologies with PTPN20B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPN20B (PTN20)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTPN20B gene (10 alternative transcripts): 
    NM_001042357.3  NM_001042358.3  NM_001042359.2  NM_001042360.2  NM_001042361.3  NM_001042362.2  NM_001042363.3  NM_001042364.3  
    NM_001042365.2  NM_015605.7  

    Unigene Cluster for PTPN20B:

    Protein tyrosine phosphatase, non-receptor type 20B
    Hs.499552  [show with all ESTs]
    Unigene Representative Sequence: NM_001042357
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
    ENST00000374237(uc001jfn.1) ENST00000331650(uc001jfh.1 uc001jfj.1 uc009xnr.1 uc001jfs.1)
    ENST00000509544(uc001jfo.1 uc001jft.1) ENST00000504747(uc001jfx.1)
    ENST00000374240(uc001jfc.1 uc001jfk.1 uc001jfp.1 uc001jfw.1)
    ENST00000374233 ENST00000507417 ENST00000514592 ENST00000513933 ENST00000505714
    ENST00000515532 ENST00000507329 ENST00000514491 ENST00000509230 ENST00000509631
    ENST00000510840 ENST00000512924 ENST00000509753
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PTPN20B (see all 14):
    hsa-miR-3163 hsa-miR-3152-3p hsa-miR-3607-3p hsa-miR-4272 hsa-miR-1258 hsa-miR-944 hsa-miR-138-2* hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidPTPN20B 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN20B
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      QuantiTect SYBR Green Assays in human, mouse, rat PTPN20B
      QuantiFast Probe-based Assays in human, mouse, rat PTPN20B

    Additional mRNA sequence: 

    AL050040.1 AY704141.1 AY704142.1 AY704143.1 AY704144.1 AY704145.1 AY704146.1 AY704147.1 
    AY704148.1 AY704149.1 AY704150.1 AY704151.1 AY704152.1 AY704153.1 AY704154.1 AY704155.1 
    AY704156.1 AY704157.1 AY704158.1 AY753191.1 BC036539.2 BC093750.1 BC113473.1 BC143394.1 
    BC171725.1 BX648913.1 CR933668.1 

    20 DOTS entries:

    DT.121285666  DT.40297888  DT.121288976  DT.121289160  DT.100745172  DT.121285649  DT.121289137  DT.121285664 
    DT.121285665  DT.121285671  DT.121288839  DT.121288902  DT.121288951  DT.121288957  DT.121289019  DT.121289024 
    DT.121289039  DT.121289173  DT.99940484  DT.121285652 

    21 AceView cDNA sequences:

    AW074840 NM_015605 BQ008756 BG655503 BG220714 CA778018 AL050040 BG121935 
    BU567804 BQ786761 AW241948 BC036539 BX648913 CD108815 BI547503 AA443172 
    BG655441 BI460524 R58088 D62174 AW868331 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPN20B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTPN20B Expression
    About this image


    PTPN20B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
     
     Testis (Reproductive System)
    PTPN20B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPN20B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.499552

    UniProtKB/Swiss-Prot: PTN20_HUMAN, Q4JDL3
    Tissue specificity: Present in many cell lines (at protein level). Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN20B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PTPN20B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn201 , 5 protein tyrosine phosphatase, non-receptor type 201, 5 77.83(n)1
    65.31(a)1
      14 (20.51 cM)5
    192561  NM_008978.21  NP_033004.11 
     335892705 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    15(a)
    1 → many
    6(17703944-17731676)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    48(a)
    1 → many
    GL343297.1(547889-583831)
    zebrafish
    (Danio rerio)
    Actinopterygii ptpn66
    protein tyrosine phosphatase, non-receptor type 6
    9(a)
    many ↔ many
    16(33958373-33978787) ENSDARG00000089043
    worm
    (Caenorhabditis elegans)
    Secernentea K07F5.86
    ZK484.76
    (see all 23)
    Protein ZK484.7 (ZK484.7) mRNA, complete cds
    (see all 23)
    25(a)
    23(a)
    (see all 23)
    many ↔ many
    many ↔ many
    (see all 23)
    IV(9848483-9849724) WBGene00010636
    I(6095055-6096589) WBGene00022753
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PTP11 PTP1 48.51(n)
    36.19(a)
      843516  NM_001036189.1  NP_001031266.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g01748001 Os12g0174800 46.58(n)
    37.24(a)
      4351645  NM_001072821.1  NP_001066289.1 


    ENSEMBL Gene Tree for PTPN20B (if available)
    TreeFam Gene Tree for PTPN20B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPN20B gene
    PTPN12  PTPN222  PTPN112  PTPN92  PTPN62  PTPRN22  PTPRN2  PTPN142  
    PTPN212  PTPN22  PTPN122  PTPN182  PTPN20A2  
    Selected SIMAP similar genes for PTPN20B using alignment to 3 protein entries:     PTN20_HUMAN (see all proteins) (see all similar genes):
    DKFZp566K0524    PTPN20A    DKFZp781P23155    PTPN20    PTPRR    DKFZp686B1310
    LAR    PTPRF    PTPsigma    PTN2    PTPN13    PTPN2
    PTPRD    PTPRS    DKFZp686E13109    PTPRB    DKFZp686N0569    PTPN3

    Find genes that share paralogs with PTPN20B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPN20B (see all 108)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122628821,2
    C,F,A--43510944(+) AAAACC/AAGCTA 1 -- int12Minor allele frequency- A:0.33NA 6
    rs1998967641,2
    C--48740034(+) CAACTG/TAACAG 10 -- int10--------
    rs2010121931,2
    C--48740041(+) ACAGGA/TTATAG 10 -- int10--------
    rs2008048301,2
    C--48740258(+) CTTTTA/TGTTTT 10 -- int10--------
    rs1926540041,2
    C--48740388(+) GGTGCA/GTTCCA 10 -- int10--------
    rs2013709831,2
    C--48740720(+) TGTGT-/GAGAGTG 10 -- int10--------
    rs561063291,2
    C--48743695(+) AAATAC/TCCTGA 10 -- int10--------
    rs1437024431,2
    C--48745889(+) CCCTGC/TCTGGA 10 -- int10--------
    rs2011687381,2
    C--48747400(+) GTCAAA/TAGGCA 10 -- int10--------
    rs1849450141,2
    C--48749769(+) ATCCCC/TGATGA 10 -- int10--------

    HapMap Linkage Disequilibrium report for PTPN20B (48736874 - 48827966 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTPN20B (see all 39):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820767CNV Deletion20802225
    nsv436102CNV Deletion17901297
    esv2736163CNV Deletion23290073
    nsv820873CNV Deletion20802225
    dgv136e199CNV Deletion23128226
    nsv895348CNV Loss21882294
    nsv433259CNV Loss18776910
    nsv895344CNV Loss21882294
    esv2750898CNV Loss17911159
    nsv895117CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTPN20B
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPN20B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610631    OMIM disorders: --


    Find genes that share disorders with PTPN20B           About GenesLikeMe


    Export disorders for PTPN20B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPN20B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PTPN20B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization. (PubMed id 15790311)1, 2, 3 Fodero-Tavoletti M.T.... Tiganis T. (Biochem. J. 2005)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26095 HGNC: 23423 AceView: DKFZP566K0524.1 Ensembl:ENSG00000183675 euGenes: HUgn26095
    ECgene: PTPN20B H-InvDB: PTPN20B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPN20B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPN20B gene:
    Search GeneIP for patents involving PTPN20B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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