PTPN20A Gene
protein-coding GIFtS: 40
GCID: GC10M046550
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protein tyrosine phosphatase, non-receptor type 20A
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Aliases for PTPN20A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Protein Tyrosine Phosphatase, Non-Receptor Type 20A1 2 | | EC 3.1.3.483 8 | | CT1261 2 | | PTPN20B2 | | BA142I17.11 | | Cancer/Testis Antigen 1262 | | HPTPN201 | | Tyrosine-Protein Phosphatase Non-Receptor Type 202 |
Export aliases for PTPN20A gene to outside databasesPrevious GC identifers: GC10U900462 GC10M045970 GC10M043492 |
Summaries for PTPN20A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for PTPN20A: The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Manyprotein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated inhuman diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein tyrosinephosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and PTPN20B. A thirdcopy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene encodes the morecentromeric copy, PTPN20A. Multiple alternatively spliced transcript variants encoding different isoforms have beenidentified. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: PTN20_HUMAN, Q4JDL3Function: Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellularstimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates
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Genomic Views for PTPN20A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_031847.8
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PTPN20A gene promoter: MEF-2A GR AML1a FOXC1 MEF-2 aMEF-2 GR-alpha FOXL1 Other transcription factors
Search SABiosciences Chromatin IP Primers for PTPN20A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN20A |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.22 Ensembl cytogenetic band: 10q11.22 HGNC cytogenetic band: 10q11.22PTPN20A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M046550: view genomic region
(about GC identifiers)
Start:
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46,549,955 bp from pter |
End:
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46,641,045 bp from pter |
Size:
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91,091 bases |
Orientation:
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minus strand |
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Proteins for PTPN20A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: PTN20_HUMAN, Q4JDL3 (See
protein sequence)Recommended Name: Tyrosine-protein phosphatase non-receptor type 20 Size: 420 amino acids; 48423 Da
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Colocalizes with themicrotubule-organizing center and intracellular membrane compartments
Sequence caution: Sequence=AAW28797.1; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: A6NNH8 B7ZKV3 Q4JDG6 Q4JDK1 Q4JDK5 Q4JDK6 Q4JDK8 Q4JDK9 Q4JDL0 Q4JDL1 Q4JDL4Q4JDL5 Q4JDL6 Q4JDL7 Q4JDL8 Q5RJ33 Q5T1G3Alternative splicing: 15 isoforms: Q4JDL3-1 Q4JDL3-2 Q4JDL3-3 Q4JDL3-4 Q4JDL3-5 Q4JDL3-6 Q4JDL3-7 Q4JDL3-8 Q4JDL3-9 Q4JDL3-10 Q4JDL3-11 Q4JDL3-12 Q4JDL3-13 Q4JDL3-14 Q4JDL3-15 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for PTPN20A: NX_Q4JDL3
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4JDL3 4 DME Specific Peptides for PTPN20A (Q4JDL3)
PTPN20A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (10 alternative transcripts):
NP_001035846.1 NP_001035848.1 NP_001035849.1 NP_001035850.1 NP_001035851.1 NP_001035852.1 NP_001035853.1 NP_001035854.1 NP_001035855.1 NP_001035856.1 ENSEMBL proteins: ENSP00000379071 ENSP00000363466 ENSP00000424491 ENSP00000363459 ENSP00000379077 ENSP00000423819 ENSP00000427676 ENSP00000421921 ENSP00000422839 ENSP00000420995 ENSP00000426355 ENSP00000425362 ENSP00000424283 ENSP00000425012 ENSP00000421453 ENSP00000425912 ENSP00000421404 ENSP00000396009 ENSP00000426681 ENSP00000422384 ENSP00000403444 ENSP00000363462 ENSP00000379072 ENSP00000363335 ENSP00000379075 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
PTPN20A for ontologies About GeneDecksing
PTPN20A Antibody Products: Assay Products for PTPN20A: |
Protein
Domains / Families for PTPN20A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PTPN20A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q4JDL3ProtoNet protein and cluster: Q4JDL3 1 Blocks protein family: IPB000242 Protein tyrosine phosphatase signature
UniProtKB/Swiss-Prot: PTN20_HUMAN, Q4JDL3Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamilySimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function for PTPN20A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: PTN20_HUMAN, Q4JDL3Function: Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellularstimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substratesCatalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateEnzyme Number (IUBMB): EC 3.1.3.481 2
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN20A (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN20A (see all 10) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 10): PTPN20A (NM_001042390) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTPN20A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN20A  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN20A |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004725 | protein tyrosine phosphatase activity |
IEA | -- | | GO:0004872 | receptor activity |
-- | -- |
PTPN20A for ontologies About GeneDecksing
|
Pathways & Interactions for PTPN20A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PAK Pathway | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPN20A
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PTPN20A
|
Drugs & Compounds for PTPN20A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for PTPN20A Search CenterWatch for drugs/clinical trials and news about PTPN20A / PTN20 
|
Transcripts for PTPN20A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for PTPN20A gene (10 alternative transcripts): NM_001042387.1 NM_001042389.1 NM_001042390.1 NM_001042391.1 NM_001042392.1 NM_001042393.1 NM_001042394.1 NM_001042395.1 NM_001042396.1 NM_001042397.1 Unigene Cluster for PTPN20A: Protein tyrosine phosphatase, non-receptor type 20A Hs.440733 [show with all ESTs]Unigene Representative Sequence: NM_00104238918/32 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32): ENST00000374340(uc001jdk.1) ENST00000395721(uc001jde.1 uc001jdg.1 uc009xmw.1 uc001jdp.1) ENST00000246887(uc001jdl.1 uc001jdq.1) ENST00000509181(uc001jdu.1) ENST00000374346(uc001jcz.1 uc001jdh.1 uc001jdm.1 uc001jdt.1) ENST00000508602 ENST00000374339 ENST00000395727 ENST00000509900 ENST00000503851 ENST00000506080 ENST00000513266 ENST00000502705 ENST00000505814 ENST00000509774 ENST00000511769 ENST00000513159 ENST00000509599
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN20A (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN20A (see all 10) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 10): PTPN20A (NM_001042390) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTPN20A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN20A  |
Additional cDNA sequence: AL050040.1 AY704141.1 AY704142.1 AY704143.1 AY704144.1 AY704145.1 AY704146.1 AY704147.1 AY704148.1 AY704149.1 AY704150.1 AY704151.1 AY704152.1 AY704153.1 AY704154.1 AY704155.1 AY704156.1 AY704157.1 AY704158.1 AY753191.1 BC036539.2 BC093750.1 BC113473.1 BC143394.1 BC171725.1 BX648913.1 CR933668.1 24/25 DOTS entries (see all 25): DT.40297888 DT.100745172 DT.121288976 DT.121289160 DT.121285666 DT.121288957 DT.121289024 DT.121289173 DT.99940484 DT.121285649 DT.121288951 DT.121289019 DT.121289039 DT.121285664 DT.121285665 DT.121285671 DT.121288839 DT.121288848 DT.121288902 DT.121289137 DT.121285645 DT.121288849 DT.121285655 DT.121285661 GeneLoc Exon Structure
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Expression for PTPN20A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PTPN20A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See PTPN20A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PTPN20A
SOURCE GeneReport for Unigene cluster: Hs.440733 UniProtKB/Swiss-Prot: PTN20_HUMAN, Q4JDL3Tissue specificity: Present in many cell lines (at protein level). Widely expressed SABiosciences Custom PCR Arrays for PTPN20A
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN20A Browse OriGene validated miRNA SYBR primer pairs
| |  | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat PTPN20A | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN20A | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN20A | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN20A |
Orthologs for PTPN20A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PTPN20A gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for PTPN20A (if available) TreeFam Gene Tree for PTPN20A (if available)  |
Paralogs for PTPN20A gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for PTPN20A gene
- PTPN20B1 2 PTPN12 PTPN32 PTPN20C2 FRMPD22 PTPN42 PTPN132 PTPN92
- PTPN142 PTPN212 PTPN22
18/39 SIMAP similar genes for PTPN20A using alignment to 6 protein entries: PTN20_HUMAN (see all proteins)
(see all similar genes):DKFZp781P23155 PTPN20 PTPN20B DKFZp566K0524 DKFZp781C1038 PTPRR DKFZp686B1310 LAR PTPRF PTPsigma PTPN13 PTPN2 PTPRD PTPRS DKFZp686E13109 PTPRB BPTP-2 DKFZp686N0569
PTPN20A for paralogs About GeneDecksing
|
Genomic Variants for PTPN20A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 10 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for PTPN20A (46549955 - 46641045 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 21 variations for PTPN20A 15/20 CNVs (see all 20): 9150 8652 48536 3798 65654 4691 34456 48538 48539 30486 65652 3799 48537 8651 31728 1 Indel: 33523  | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases for PTPN20A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PTPN20A for disorders About MalaCards
PTPN20A for disorders About GeneDecksing
OMIM gene information: 610630
OMIM disorders: --
Export disorders for PTPN20A gene to outside databases
|
Publications for PTPN20A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PTPN20A gene integrated from 9 sources: (articles sorted by number of sources associating them with PTPN20A) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization. (PubMed id 15790311)1, 2 Fodero-Tavoletti M.T.... Tiganis T. (2005)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for PTPN20A gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PTPN20A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PTPN20A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PTPN20A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for PTPN20A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PTPN20A gene: Search GeneIP for patents involving PTPN20A
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for PTPN20A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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 | | PTPN20A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN20A |
|  |  |  | | | Search ThermoFisher Antibodies for PTPN20A |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN20A |
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