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Aliases for PTPN20 Gene

Aliases for PTPN20 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 20 2 3
  • Protein Tyrosine Phosphatase, Non-Receptor Type 20A 2 3
  • Protein Tyrosine Phosphatase, Non-Receptor Type 20B 2 3
  • EC 4 63
  • HPTPN20 3 4
  • Tyrosine-Protein Phosphatase Non-Receptor Type 20 3
  • Cancer/Testis Antigen 126 3
  • PTPN20A PTPN20B 4
  • BA142I17.1 3
  • BA42B19.1 3
  • PTPN20A 3
  • PTPN20B 3
  • CT126 3

External Ids for PTPN20 Gene

Previous Symbols for PTPN20 Gene

  • PTPN20A
  • PTPN20B

Summaries for PTPN20 Gene

Entrez Gene Summary for PTPN20 Gene

  • The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for PTPN20 Gene

PTPN20 (Protein Tyrosine Phosphatase, Non-Receptor Type 20) is a Protein Coding gene. Among its related pathways are PAK Pathway. An important paralog of this gene is PTPN6.

UniProtKB/Swiss-Prot for PTPN20 Gene

  • Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN20 Gene

Genomics for PTPN20 Gene

Genomic Location for PTPN20 Gene

46,911,396 bp from pter
47,002,488 bp from pter
91,093 bases
Plus strand

Genomic View for PTPN20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN20 Gene

No data available for Regulatory Elements for PTPN20 Gene

Proteins for PTPN20 Gene

  • Protein details for PTPN20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 20
    Protein Accession:
    Secondary Accessions:
    • A6NNH8
    • B7ZKV3
    • Q4JDG6
    • Q4JDK1
    • Q4JDK5
    • Q4JDK6
    • Q4JDK8
    • Q4JDK9
    • Q4JDL0
    • Q4JDL1
    • Q4JDL4
    • Q4JDL5
    • Q4JDL6
    • Q4JDL7
    • Q4JDL8
    • Q5RJ33
    • Q5T1G3

    Protein attributes for PTPN20 Gene

    420 amino acids
    Molecular mass:
    48423 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAW28797.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for PTPN20 Gene

Proteomics data for PTPN20 Gene at MOPED

Selected DME Specific Peptides for PTPN20 Gene

Post-translational modifications for PTPN20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for PTPN20 Gene

Gene Families for PTPN20 Gene

  • PTPN :Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

Suggested Antigen Peptide Sequences for PTPN20 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 tyrosine-protein phosphatase domain.:
    • Q4JDL3
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.:
    • Q4JDL3
genes like me logo Genes that share domains with PTPN20: view

Function for PTPN20 Gene

Molecular function for PTPN20 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates

Enzyme Numbers (IUBMB) for PTPN20 Gene

Gene Ontology (GO) - Molecular Function for PTPN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPN20: view

Phenotypes for PTPN20 Gene

GenomeRNAi human phenotypes for PTPN20:
genes like me logo Genes that share phenotypes with PTPN20: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PTPN20 Gene

Localization for PTPN20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN20 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the microtubule-organizing center and intracellular membrane compartments.

Gene Ontology (GO) - Cellular Components for PTPN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with PTPN20: view

No data available for Subcellular locations from COMPARTMENTS for PTPN20 Gene

Pathways for PTPN20 Gene

SuperPathways for PTPN20 Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPN20: view

Pathways by source for PTPN20 Gene

1 Qiagen pathway for PTPN20 Gene

Interacting Proteins for PTPN20 Gene

Gene Ontology (GO) - Biological Process for PTPN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with PTPN20: view

Transcripts for PTPN20 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN20 Gene

No ASD Table

Relevant External Links for PTPN20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPN20 Gene

mRNA expression in normal human tissues for PTPN20 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTPN20 Gene

mRNA Expression by UniProt/SwissProt for PTPN20 Gene

Tissue specificity: Present in many cell lines (at protein level). Widely expressed.
genes like me logo Genes that share expressions with PTPN20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PTPN20 Gene

Orthologs for PTPN20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PTPN20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
PTPN20A 35
  • 99.44 (n)
  • 99.52 (a)
(Bos Taurus)
Mammalia -- 36
  • 69 (a)
PTPN20B 35
  • 79.52 (n)
  • 68.04 (a)
(Canis familiaris)
Mammalia -- 36
  • 67 (a)
PTPN20B 35
  • 84.5 (n)
  • 72.77 (a)
(Mus musculus)
Mammalia Ptpn20 35
  • 77.83 (n)
  • 65.31 (a)
Ptpn20 16
Ptpn20 36
  • 64 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
(Rattus norvegicus)
Mammalia Ptpn20b 35
  • 78.6 (n)
  • 66.35 (a)
(Gallus gallus)
Aves -- 36
  • 15 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
(Danio rerio)
Actinopterygii ptpn11b 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea B0207.1 36
  • 14 (a)
C02B10.6 36
  • 20 (a)
C17H12.3 36
  • 21 (a)
C33H5.16 36
  • 20 (a)
C55B7.3 36
  • 22 (a)
F10G8.1 36
  • 21 (a)
F20H11.4 36
  • 20 (a)
F25H5.7 36
  • 17 (a)
F36H1.3 36
  • 17 (a)
F36H12.10 36
  • 20 (a)
F47B3.1 36
  • 20 (a)
F47B3.6 36
  • 22 (a)
F47B3.7 36
  • 23 (a)
F55F8.7 36
  • 19 (a)
K07F5.8 36
  • 25 (a)
M04G7.2 36
  • 16 (a)
T22C1.8 36
  • 13 (a)
T27A3.5 36
  • 23 (a)
T28F4.3 36
  • 17 (a)
Y48G9A.9 36
  • 22 (a)
ZK354.8 36
  • 16 (a)
ZK484.7 36
  • 23 (a)
ZK616.8 36
  • 13 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PTP1 35
  • 48.51 (n)
  • 36.19 (a)
(Oryza sativa)
Liliopsida Os12g0174800 35
  • 46.58 (n)
  • 37.24 (a)
Species with no ortholog for PTPN20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPN20 Gene

Gene Tree for PTPN20 (if available)
Gene Tree for PTPN20 (if available)

Paralogs for PTPN20 Gene

Selected SIMAP similar genes for PTPN20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PTPN20: view

Variants for PTPN20 Gene

Sequence variations from dbSNP and Humsavar for PTPN20 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs711893 -- 46,963,584(-) GTACA(C/G)ACATA intron-variant
rs1501835 -- 46,933,486(-) TGGTT(G/T)CCAGG intron-variant
rs1594260 -- 46,933,528(-) TACAG(A/G)TGGAA intron-variant
rs1832606 -- 46,989,593(-) ATCCC(C/T)GATGA intron-variant
rs1832612 -- 46,978,634(-) gactc(A/G)cctca intron-variant

Relevant External Links for PTPN20 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PTPN20 Gene

Disorders for PTPN20 Gene

No disorders were found for PTPN20 Gene.

No data available for UniProtKB/Swiss-Prot for PTPN20 Gene

Publications for PTPN20 Gene

  1. Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization. (PMID: 15790311) Fodero-Tavoletti M.T. … Tiganis T. (Biochem. J. 2005) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PTPN20 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PTPN20
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN20
    • Block miRNA regulation of PTPN20 using miScript Target Protectors

    Sources for PTPN20 Gene

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