PTPN2 Gene
protein-coding GIFtS: 67
GCID: GC18M012775
|
|
protein tyrosine phosphatase, non-receptor type 2
(Previous symbol: PTPT)
| |
Aliases
for PTPN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Tyrosine Phosphatase, Non-Receptor Type 21 2 | | EC 3.1.3.483 8 | | PTPT1 2 3 5 | | PTN22 | | TCPTP1 2 3 | | T-Cell Protein Tyrosine Phosphatase2 | | TC-PTP1 2 | | Tyrosine-Protein Phosphatase Non-Receptor Type 22 | | TCELLPTP1 2 | | T-Cell Protein-Tyrosine Phosphatase3 |
Export aliases for PTPN2 gene to outside databasesPrevious GC identifer: GC18M012820 |
Summaries
for PTPN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PTPN2:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTPfamily share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to besignaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitoticcycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to besubstrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternativelyspliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processedpseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. (provided by RefSeq, May 2011)
Gene Wiki entry for PTPN2
|
Genomic Views
for PTPN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PTPN2 gene promoter:
STAT5B NF-kappaB NF-kappaB1 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for PTPN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.3-p11.2 Ensembl cytogenetic band: 18p11.21 HGNC cytogenetic band: 18p11.3-p11.2PTPN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M012775: view genomic region
(about GC identifiers)
Start:
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12,785,477 bp from pter |
End:
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12,929,642 bp from pter |
Size:
|
144,166 bases |
Orientation:
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minus strand |
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Proteins
for PTPN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PTN2_HUMAN, P17706 (See
protein sequence)Recommended Name: Tyrosine-protein phosphatase non-receptor type 2 Size: 415 amino acids; 48473 Da
Subunit: Interacts with RMDN3. Isoform PTPB interacts with TMED9
Subcellular location: Cytoplasm
Subcellular location: Isoform PTPB: Endoplasmic reticulum
Subcellular location: Isoform PTPA: Nucleus
1 PDB 3D structure from  and Proteopedia  for PTPN2:1L8K (3D)
Secondary accessions: A8K955 A8MXU3 Q96AU5 Q96HR2Alternative splicing: 3 isoforms: P17706-1 P17706-2 P17706-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PTPN2: NX_P17706
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17706
4/7 DME Specific Peptides for PTPN2 (P17706) (see all 7)
PTPN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001193942.1 NP_002819.2 NP_536347.1 NP_536348.1
ENSEMBL proteins: ENSP00000320298 ENSP00000464937 ENSP00000466936 ENSP00000320546 ENSP00000464719 ENSP00000467043 ENSP00000467823 ENSP00000311857 ENSP00000468012 ENSP00000468155 ENSP00000468408 ENSP00000466206 Reactome Protein details: P17706
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PTPN2 for ontologies About GeneDecksing
PTPN2 Antibody Products:
Assay Products for PTPN2: |
Protein
Domains /
Families
for PTPN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PTPN2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17706ProtoNet protein and cluster: P17706 1 Blocks protein family: IPB000242 Protein tyrosine phosphatase signature
UniProtKB/Swiss-Prot: PTN2_HUMAN, P17706Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamilySimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function
for PTPN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PTN2_HUMAN, P17706Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate Genatlas biochemistry entry for PTPN2:protein tyrosine phosphatase,non receptor type 2,T-cell
Enzyme Number (IUBMB): EC 3.1.3.481 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): PTPN2 (NM_080422) | |  | Sino Biological Human cDNA Clone for PTPN2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTPN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
PTPN2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PTPN2:
Animal Models:
Mouse knock-outs for PTPN2: Ptpn2tm1Mtr Ptpn2tm2.1Ttig
12 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Ptpn2):
PTPN2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PTPN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of cAMP-Dependent PKA | | | 2 | Cytokine Signaling in Immune system | | | 3 | Immune System | | | 4 | Interferon gamma signaling | | | 5 | Regulation of IFNG signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTPN2 (see all 6)
5 
Reactome Pathways for PTPN2
PTPN2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/36 Interacting proteins for PTPN2 (P177061, 2, 3 ENSP000003118574) via UniProtKB, MINT, STRING, and/or I2D (see all 36)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| GHR | P109121, 2, 3, ENSP000002308824 | EBI-984930,EBI-286316 MINT-6797701 MINT-6797461 MINT-6797520 MINT-6797669 MINT-6797685 MINT-6797717 MINT-6797749 I2D:
score=3 STRING: ENSP00000230882 | | ITGA1 | P561992, 3, ENSP000002825884 | MINT-8284727 MINT-8284737 I2D:
score=1 STRING: ENSP00000282588 | | SFN | P319472, 3 | MINT-3975592 I2D:
score=2 | | INSR | P062132, 3, ENSP000003038304 | MINT-8284848 MINT-8284879 I2D:
score=1 STRING: ENSP00000303830 | | EGFR | P005332, 3, ENSP000002754934 | MINT-8284755 I2D:
score=1 STRING: ENSP00000275493 |
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
PTPN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PTPN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PTPN2 for compounds About GeneDecksing
 Browse Tocris compounds for PTPN2
2 HMDB Compounds for PTPN2 About this table
8 Novoseek chemical compound relationships for PTPN2 gene About this table
Search CenterWatch for drugs/clinical trials and news about PTPN2 / PTN2
|
Transcripts
for PTPN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PTPN2 gene (4 alternative transcripts): NM_001207013.1 NM_002828.3 NM_080422.2 NM_080423.2 Unigene Cluster for PTPN2: Protein tyrosine phosphatase, non-receptor type 2 Hs.654527 [show with all ESTs]Unigene Representative Sequence: NM_00282815 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000589444 ENST00000327283(uc002krn.3 uc002krl.3 uc002krm.3)
ENST00000591901 ENST00000591115 ENST00000353319 ENST00000585666 ENST00000587703
ENST00000591497 ENST00000309660(uc002krp.3) ENST00000591305 ENST00000587497
ENST00000592776 ENST00000589216 ENST00000592059 ENST00000589086
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): PTPN2 (NM_080422) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTPN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN2 |
Additional cDNA sequence: AB209569.1 AK091525.1 AK225706.1 AK290649.1 AK292570.1 BC008244.1 BC016727.1 M25393.1 M80737.1 M81478.1 17 DOTS entries: DT.116838 DT.95305286 DT.86855310 DT.100794766 DT.99932109 DT.108121 DT.100026870 DT.100794762 DT.121429203 DT.100794765 DT.100740132 DT.100837656 DT.121090303 DT.91756333 DT.120795222 DT.121090299 DT.402933 24/210 AceView cDNA sequences (see all 210): BM822320 BQ775640 BU509839 NM_080422 AA424635 CB131601 BX485997 BX357404 CA503346 CR621000 BM712494 BC008244 CD679338 F08556 BM450334 BM831356 CK301036 AA478220 AU119325 BQ010946 AL041460 AA301459 AA301420 BM727736
GeneLoc Exon Structure
|
Expression
for PTPN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PTPN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTGAGAAT
About this image
See PTPN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTPN2
SOURCE GeneReport for Unigene cluster: Hs.654527
UniProtKB/Swiss-Prot: PTN2_HUMAN, P17706Tissue specificity: Isoform PTPA is probably the major isoform. Isoform PTPB is expressed in T-cells and in placenta
SABiosciences Expression via Pathway-Focused PCR Array including PTPN2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTPN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN2 |
Orthologs
for PTPN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PTPN2 gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PTPN21 |
protein tyrosine phosphatase, non-receptor type 2 |
78.04(n)
79.33(a) |
|
396409 NM_001199387.1 NP_001186316.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PTPN26 |
-- |
70(a) |
1 ↔ 1 |
4(42841272-42861905) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BX851447.12 |
-- |
77.92(n) |
|
BX851447.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC055169.12 |
-- |
74.48(n) |
|
393438 BC055169.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ptp61F3 |
axon guidance protein tyrosine phosphatase |
46(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
ZK484.73 |
protein tyrosine phosphatase |
33(a) |
|
I(6103267-6104652) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATPTP16 |
tyrosine phosphatase 1 |
22(a) |
1 → many |
1(27026711-27029092) |
rice
(Oryza sativa) |
Liliopsida |
---- |
Protein-tyrosine phosphatase domain containing pro...Protein-tyrosine phosphatase domain containing pro... |
22(a)20(a) |
many ↔ manymany ↔ many |
12(3791109-3796496) 11(4000708-4008336) |
ENSEMBL Gene Tree for PTPN2 (if available)
TreeFam Gene Tree for PTPN2 (if available) |
Paralogs
for PTPN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PTPN2 gene
- PTPN12 PTPN32 PTPN20C2 FRMPD22 PTPN42 PTPN132 PTPN92 PTPN142
- PTPN20B2 PTPN212 PTPN20A2
18/40 SIMAP similar genes for PTPN2 using alignment to 11 protein entries: PTN2_HUMAN (see all proteins)
(see all similar genes):PTPN1 PTPRO DKFZp686N0569 PTPN20A PTPN20B PTPN3
BPTP-3 DKFZp566K0524 DKFZp686E13109 PTPN4 DKFZp781C1038 PTPRB
PTPN13 PTPN14 PTPN5 DKFZp686B1310 DKFZp686C2268 LAR
PTPN2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for PTPN2
PGOHUM00000248558 PGOHUM00000244353
|
Genomic Variants
for PTPN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PTPN2 (12785477 - 12929642 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PTPN2
2 Indels: 11926 42974
Human Gene Mutation Database (HGMD): PTPN2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPN2 |
|
Disorders
/ Diseases
for PTPN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PTPN2 for disorders About GeneDecksing
OMIM gene information: 176887
OMIM disorders: --
20  diseases for PTPN2: About MalaCardsdiffuse large b-cell lymphoma wiskott-aldrich syndrome b-cell lymphomas ankylosing spondylitis
acute lymphoblastic leukemia lymphoblastic leukemia blastoma ulcerative colitis
spondylitis celiac disease rheumatoid arthritis crohn's disease
vasculitis arthritis leukemia prostate cancer
prostatitis pancreatitis neuronitis carcinoma
1 disease from the University of Copenhagen DISEASES database for PTPN2:Crohn's disease 2 Novoseek disease relationships for PTPN2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: PTPN2 (31 documents)
Export disorders for PTPN2 gene to outside databases
|
Publications
for PTPN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PTPN2 gene, integrated from 9 sources (see all 186):
(articles sorted by number of sources associating them with PTPN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus. (PubMed id 7593185)1, 2, 9 Lorenzen J.A....Fischer E.H. (1995)
- Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER. (PubMed id 16595549)1, 2 Gupta V. and Swarup G. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structure determination of T cell protein-tyrosine phosphatase. (PubMed id 11907034)1, 2 Iversen L.F.... Moller N.P. (2002)
- Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase. (PubMed id 1731319)1, 2 Mosinger B. Jr.... Tremblay M.L. (1992)
- Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B. (PubMed id 2164224)1, 3 Brown-Shimer S.... Hill D.E. (1990)
- cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family. (PubMed id 2546150)1, 2 Cool D....Krebs E.G. (1989)
- A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. (PubMed id 11773439)1, 9 Aoki N. and Matsuda T. (2002)
- A novel mechanism for imatinib mesylate (STI571) resistance in CML cell line KT-1: role of TC-PTP in modulating signals downstream from the BCR-ABL fusion protein. (PubMed id 15539083)1, 9 Shimizu T....Kizaki M. (2004)
- Deletion of the protein tyrosine phosphatase gene PTP N2 in T-cell acute lymphoblastic leukemia. (PubMed id 20473312)1, 9 Kleppe M....Cools J. (2010)
|
External Searches for PTPN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PTPN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PTPN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PTPN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PTPN2 gene:
Search GeneIP for patents involving PTPN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PTPN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for PTPN2 | | OriGene shRNA RFP for PTPN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN2 | | | OriGene Protein Over-expression Lysate for PTPN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PTPN2 | | OriGene 3'-UTR Clone for PTPN2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PTPN2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PTPN2 | | OriGene Custom Protein Services for PTPN2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTPN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN2 |
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| | | | Search Tocris compounds for PTPN2 |
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 | | | PTPN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN2 |
|  |  |  | | | | ThermoFisher Antibodies for PTPN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN2 |
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