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PTPN2 Gene

protein-coding   GIFtS: 67
GCID: GC18M013248

Protein Tyrosine Phosphatase, Non-Receptor Type 2


(Previous symbol: PTPT)
  See PTPN2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 21 2     TC-PTP2
PTPT1 2 3 5     TCELLPTP2
TCPTP2 3     T-Cell Protein Tyrosine Phosphatase2
EC 3.1.3.483 8     Tyrosine-Protein Phosphatase Non-Receptor Type 22
PTN22     T-Cell Protein-Tyrosine Phosphatase3

External Ids:    HGNC: 96501   Entrez Gene: 57712   Ensembl: ENSG000001753547   OMIM: 1768875   UniProtKB: P177063   

Export aliases for PTPN2 gene to outside databases

Previous GC identifers: GC18M012820 GC18M012775 GC18M012864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPN2 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP
family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were
reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling.
Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly
related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been
reported. (provided by RefSeq, May 2011)

GeneCards Summary for PTPN2 Gene:
PTPN2 (protein tyrosine phosphatase, non-receptor type 2) is a protein-coding gene. Diseases associated with PTPN2 include oligoarticular juvenile arthritis, and polyarticular onset juvenile idiopathic arthritis. GO annotations related to this gene include integrin binding and protein kinase binding. An important paralog of this gene is PTPN1.

UniProtKB/Swiss-Prot: PTN2_HUMAN, P17706
Function: Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases
including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2,
JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm.
Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory
response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important
role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of
FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its
downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and
interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their
substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the
IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6
respectively. Beside the immune system, it is involved in anchorage-dependent, negative regulation of
EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively
regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor
receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis
factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte
growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET.
Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor
signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production
through negative regulation of the IL6 signaling pathways. Finally, it negatively regulates prolactin-mediated
signaling pathway through dephosphorylation of STAT5A and STAT5B. May also bind DNA

Gene Wiki entry for PTPN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010859.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPN2 gene promoter:
         STAT5B   NF-kappaB   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN2 promoter sequence
   Search Chromatin IP Primers for PTPN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.3-p11.2   Ensembl cytogenetic band:  18p11.21   HGNC cytogenetic band: 18p11.3-p11.2

PTPN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M013248:  view genomic region     (about GC identifiers)

Start:
12,785,477 bp from pter      End:
12,929,642 bp from pter
Size:
144,166 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PTN2_HUMAN, P17706 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 2  
Size: 415 amino acids; 48473 Da
Subunit: Interacts with RMDN3. Isoform 1 interacts with TMED9. Isoform 1 interacts with STX17; dephosphorylates
STX17. Interacts with ITGA1 (via cytoplasmic domain); activates the phosphatase activity towards EGFR. Interacts
with TRAF2; probably involved in tumor necrosis factor-mediated signaling. Interacts with MET
1 PDB 3D structure from and Proteopedia for PTPN2:
1L8K (3D)    
Secondary accessions: A8K955 A8MXU3 Q96AU5 Q96HR2
Alternative splicing: 3 isoforms:  P17706-1   P17706-2   P17706-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPN2: NX_P17706

Explore proteomics data for PTPN2 at MOPED

Post-translational modifications: 

  • Isoform 2: Specifically phosphorylated in a cell cycle-dependent manner by cyclin-dependent kinases. Probably
    activated through phosphorylation by PKR1
  • Ubiquitination2 at Lys60, Lys336
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTPN2 (P17706) (see all 7)
     DQLRFSY  RMGLIQT  HCSAGIGR  YILTQGPL 


    See PTPN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001193942.1  NP_002819.2  NP_536347.1  NP_536348.1  

    ENSEMBL proteins: 
     ENSP00000320298   ENSP00000464937   ENSP00000466936   ENSP00000320546   ENSP00000464719  
     ENSP00000467043   ENSP00000311857   ENSP00000467823   ENSP00000468012   ENSP00000468155  
     ENSP00000468408   ENSP00000466206  
    Reactome Protein details: P17706

    PTPN2 Human Recombinant Protein Products:

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    Novus Biologicals PTPN2 Protein
    Novus Biologicals PTPN2 Lysates
    Sino Biological Recombinant Protein for PTPN2
    Sino Biological Cell Lysate for PTPN2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTPN2

     
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    antibodies-online proteins for PTPN2 (4 products) 

     
    antibodies-online peptides for PTPN2

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    PTPN2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    4 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase
     IPR012265 Ptpn1/Ptpn2

    Graphical View of Domain Structure for InterPro Entry P17706

    ProtoNet protein and cluster: P17706

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTN2_HUMAN, P17706
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN2_HUMAN, P17706
    Function: Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases
    including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2,
    JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm.
    Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory
    response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important
    role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of
    FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its
    downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and
    interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their
    substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the
    IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6
    respectively. Beside the immune system, it is involved in anchorage-dependent, negative regulation of
    EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively
    regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor
    receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis
    factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte
    growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET.
    Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor
    signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production
    through negative regulation of the IL6 signaling pathways. Finally, it negatively regulates prolactin-mediated
    signaling pathway through dephosphorylation of STAT5A and STAT5B. May also bind DNA
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=0.48 mM for p-nitrophenyl phosphate (at pH 6.5 and 25
    degrees Celsius);
    Induction: Up-regulated by IL4/interleukin-4 (at protein level)

         Genatlas biochemistry entry for PTPN2:
    protein tyrosine phosphatase,non receptor type 2,T-cell

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IMP11909529
    GO:0004726non-membrane spanning protein tyrosine phosphatase activity ----
    GO:0005178integrin binding IPI15592458
    GO:0005515protein binding IPI12359225
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with PTPN2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PTPN2:
     Decreased number of cells in m  Increased Akt phosphorylation  

         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ptpn2):
     adipose tissue  behavior/neurological  cellular  digestive/alimentary  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail  mortality/aging 
     skeleton  vision/eye 

    Find genes that share phenotypes with PTPN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTPN2: Ptpn2tm1Mtr Ptpn2tm2.1Ttig

       genOway: Develop your customized and physiologically relevant rodent model for PTPN2

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    Selected qRT-PCR Assays for microRNAs that regulate PTPN2 (see all 21):
    hsa-miR-30c hsa-miR-137 hsa-miR-520d-5p hsa-miR-548k hsa-miR-485-3p hsa-miR-30d hsa-miR-548l hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidPTPN2 3' UTR sequence
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    Addgene plasmids for PTPN2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTN2_HUMAN, P17706: Isoform 1: Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment.
    Note=Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region (PubMed:7593185)
    PTN2_HUMAN, P17706: Isoform 2: Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localizes to chromatin (By
    similarity). Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane
    receptors (PubMed:9488479). Recruited by activated ITGA1 at the plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    cytosol2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12612081
    GO:0005654nucleoplasm TAS--
    GO:0005783endoplasmic reticulum IDA10940933
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA--
    GO:0005886colocalizes with plasma membrane IDA15592458

    Find genes that share ontologies with PTPN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPN2 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    Regulation of IFNG signaling0.00
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3TWEAK Pathway
    Apoptotic Pathways Triggered By HIV10.42
    4PAK Pathway
    Epithelial Adherens Junctions0.36


    Find genes that share SuperPaths with PTPN2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PTPN2 (see all 6)
        Activation of PKA through GPCR
    PKA Signaling
    Apoptotic Pathways Triggered By HIV1
    cAMP Pathway
    Activation of cAMP-Dependent PKA


    1 Reactome Pathway for PTPN2
        Regulation of IFNG signaling


        Pathway & Disease-focused RT2 Profiler PCR Array including PTPN2: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTPN2 (P177061, 2, 3 ENSP000003118574) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GHRP109121, 2, 3, ENSP000002308824EBI-984930,EBI-286316 MINT-6797701 MINT-6797461 MINT-6797520 MINT-6797669 MINT-6797685 MINT-6797717 MINT-6797749 I2D: score=3 STRING: ENSP00000230882
    ITGA1P561992, 3, ENSP000002825884MINT-8284727 MINT-8284737 I2D: score=1 STRING: ENSP00000282588
    SFNP319472, 3MINT-3975592 I2D: score=2 
    INSRP062132, 3, ENSP000003038304MINT-8284848 MINT-8284879 I2D: score=1 STRING: ENSP00000303830
    EGFRP005332, 3, ENSP000002754934MINT-8284755 I2D: score=1 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation ----
    GO:0008285negative regulation of cell proliferation IMP15592458
    GO:0008286insulin receptor signaling pathway ISS--
    GO:0010804negative regulation of tumor necrosis factor-mediated signaling pathway ISS--
    GO:0010888negative regulation of lipid storage ISS--

    Find genes that share ontologies with PTPN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPN2 (PTN2)

    2 HMDB Compounds for PTPN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    8 Novoseek inferred chemical compound relationships for PTPN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tc-48 95.9 9 15030318 (2), 9488479 (1), 9361013 (1), 18819921 (1)
    tyrosine 78.4 143 15696169 (4), 11352902 (3), 15592458 (2), 9488479 (2) (see all 58)
    phosphotyrosine 73.4 8 8112824 (1), 13678400 (1), 1381565 (1), 12749891 (1) (see all 5)
    imatinib 28.8 5 15539083 (3)
    threonine 21.1 1 1311309 (1)
    serine 18.2 1 1311309 (1)
    alanine 0 2 9488479 (1)
    arginine 0 1 12171910 (1)



    Find genes that share compounds with PTPN2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTPN2 gene (4 alternative transcripts): 
    NM_001207013.1  NM_002828.3  NM_080422.2  NM_080423.2  

    Unigene Cluster for PTPN2:

    Protein tyrosine phosphatase, non-receptor type 2
    Hs.654527  [show with all ESTs]
    Unigene Representative Sequence: NM_002828
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589444 ENST00000327283(uc002krn.3 uc002krl.3 uc002krm.3)
    ENST00000591901 ENST00000591115 ENST00000353319 ENST00000585666 ENST00000587703
    ENST00000309660(uc002krp.3) ENST00000591497 ENST00000591305 ENST00000587497
    ENST00000592776 ENST00000589216 ENST00000592059 ENST00000589086
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    Additional mRNA sequence: 

    AB209569.1 AK091525.1 AK225706.1 AK290649.1 AK292570.1 BC008244.1 BC016727.1 M25393.1 
    M80737.1 M81478.1 

    17 DOTS entries:

    DT.116838  DT.95305286  DT.86855310  DT.100794766  DT.99932109  DT.108121  DT.100026870  DT.100794762 
    DT.121429203  DT.100794765  DT.100740132  DT.100837656  DT.121090303  DT.91756333  DT.120795222  DT.121090299 
    DT.402933 

    Selected AceView cDNA sequences (see all 210):

    T17417 AA424635 BU509839 AL041460 BQ775640 CR614824 CR615196 CR621000 
    AA478220 X93568 BX357404 BU632404 NM_080422 BX279723 BX482995 AU119325 
    AA301420 CB130221 CK301036 BM712494 CR604688 CB131601 BM822320 CD299953 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTGAGAAT
    PTPN2 Expression
    About this image


    PTPN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PTPN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654527

    UniProtKB/Swiss-Prot: PTN2_HUMAN, P17706
    Tissue specificity: Ubiquitously expressed. Isoform 2 is probably the major isoform. Isoform 1 is expressed in
    T-cells and in placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including PTPN2: 
              Protein Phosphatases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTPN2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn21 , 5 protein tyrosine phosphatase, non-receptor type 21, 5 88.92(n)1
    90.64(a)1
      18 (40.06 cM)5
    192551  NM_001127177.11  NP_001120649.11 
     676655115 
    chicken
    (Gallus gallus)
    Aves PTPN21 protein tyrosine phosphatase, non-receptor type 2 77.95(n)
    79(a)
      396409  NM_001199387.1  NP_001186316.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN26
    protein tyrosine phosphatase, non-receptor type 2
    70(a)
    1 ↔ 1
    4(42837624-42870410)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX851447.12   -- 77.92(n)    BX851447.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055169.12   -- 74.48(n)   393438  BC055169.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ptp61F1 , 3 axon guidance protein tyrosine
    phosphatase3
    Protein tyrosine phosphatase 61F1
    46(a)3
    55.31(n)1
    52.59(a)1
      381601  NM_057339.41  NP_476687.11 


    ENSEMBL Gene Tree for PTPN2 (if available)
    TreeFam Gene Tree for PTPN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPN2 gene
    PTPN12  PTPN222  PTPN112  PTPN92  PTPN62  PTPRN22  PTPRN2  PTPN142  
    PTPN212  PTPN20B2  PTPN122  PTPN182  PTPN20A2  
    Selected SIMAP similar genes for PTPN2 using alignment to 10 protein entries:     PTN2_HUMAN (see all proteins) (see all similar genes):
    PTN2    PTPN1    PTPN22    PTPRO    PTPN20A    PTPN20B
    BPTP-3    DKFZp566K0524    PTPN3    DKFZp781C1038    PTPN4    PTPRB
    PTPN5    PTPRG    PTPRZ1    PTPN7    PTPRK    PTPRM

    Find genes that share paralogs with PTPN2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for PTPN2
    PGOHUM00000248558 PGOHUM00000244353


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPN2 (see all 2254)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1412584971,2
    Cuntested112782662(+) AAAGCA/GCCAAC 5 G syn1 int10--------
    rs1499600251,2
    C--12773409(+) ATTAT-/TGCTTTCA 3 -- ds50010--------
    rs1999514191,2
    --12773470(+) AAACC-/TTTTTT 3 -- ds50010--------
    rs1455769891,2
    --12773495(+) TTTCAC/TTCATT 3 -- ds50010--------
    rs455185401,2
    C,F--12773522(-) ATCGCA/GCCACT 3 -- ds50012Minor allele frequency- G:0.12NS WA 40
    rs1410931451,2
    C--12773525(+) GGTGCA/GATTTT 3 -- ds50010--------
    rs25421551,2
    F--12773555(+) CTCCCG/AGGTTC 3 -- ds50012Minor allele frequency- A:0.50NA 4
    rs1448162921,2
    C--12773606(+) ACAGGC/TGCCTA 3 -- ds50010--------
    rs455107991,2
    C,F--12773611(+) TGCCTA/GCTACC 3 -- ds50012Minor allele frequency- G:0.11NS NA 158
    rs72321461,2
    C,F--12773711(+) cacccG/Acctcg 3 -- ds50011Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for PTPN2 (12785477 - 12929642 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PTPN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716815CNV Deletion23290073
    esv3172CNV Deletion18987735
    nsv131711CNV Insertion16902084
    nsv909407CNV Loss21882294
    nsv130834CNV Loss16902084

    Human Gene Mutation Database (HGMD): PTPN2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTPN2
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176887    OMIM disorders: --

    2 diseases for PTPN2:    
    About MalaCards
    oligoarticular juvenile arthritis    polyarticular onset juvenile idiopathic arthritis

    1 disease from the University of Copenhagen DISEASES database for PTPN2:
    Crohn's disease

    Find genes that share disorders with PTPN2           About GenesLikeMe

    2 Novoseek inferred disease relationships for PTPN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 15 1 18236007 (1)
    tumors 0 9 17210636 (2), 15696169 (1), 19635455 (1), 20473312 (1)

    Genetic Association Database (GAD): PTPN2
    Human Genome Epidemiology (HuGE) Navigator: PTPN2 (31 documents)

    Export disorders for PTPN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPN2 gene, integrated from 10 sources (see all 203):
    (articles sorted by number of sources associating them with PTPN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. (PubMed id 17210636)1, 2, 9 Lu X....Lossos I.S. (Mol. Cell. Biol. 2007)
    2. Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. (PubMed id 18819921)1, 2, 9 Sangwan V....Park M. (J. Biol. Chem. 2008)
    3. The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. (PubMed id 12359225)1, 2, 9 Yamamoto T....Matsuda T. (Biochem. Biophys. Res. Commun. 2002)
    4. Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. (PubMed id 15696169)1, 2, 9 van Vliet C....Tiganis T. (Nat. Immunol. 2005)
    5. Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase. (PubMed id 9488479)1, 2, 9 Tiganis T....Tonks N.K. (Mol. Cell. Biol. 1998)
    6. The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis. (PubMed id 15030318)1, 2, 9 Bukczynska P....Tiganis T. (Biochem. J. 2004)
    7. COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus. (PubMed id 7593185)1, 2, 9 Lorenzen J.A.... Fischer E.H. (J. Cell Biol. 1995)
    8. Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP. (PubMed id 15592458)1, 2, 9 Mattila E....Ivaska J. (Nat. Cell Biol. 2005)
    9. Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP. (PubMed id 12612081)1, 2, 9 Galic S....Tiganis T. (Mol. Cell. Biol. 2003)
    10. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)1, 4 Okada Y....Yamamoto K. (Nat. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5771 HGNC: 9650 AceView: PTPN2 Ensembl:ENSG00000175354 euGenes: HUgn5771
    ECgene: PTPN2 H-InvDB: PTPN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPN2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPN2 gene:
    Search GeneIP for patents involving PTPN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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