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Aliases for PTPN2 Gene

Aliases for PTPN2 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 2 2 3
  • EC 3.1.3.48 4 63
  • TCPTP 3 4
  • PTPT 3 4
  • T-Cell Protein Tyrosine Phosphatase 3
  • T-Cell Protein-Tyrosine Phosphatase 4
  • TCELLPTP 3
  • TC-PTP 3
  • PTN2 3

External Ids for PTPN2 Gene

Previous HGNC Symbols for PTPN2 Gene

  • PTPT

Previous GeneCards Identifiers for PTPN2 Gene

  • GC18M012820
  • GC18M012775
  • GC18M012864
  • GC18M013248
  • GC18M013090

Summaries for PTPN2 Gene

Entrez Gene Summary for PTPN2 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

GeneCards Summary for PTPN2 Gene

PTPN2 (Protein Tyrosine Phosphatase, Non-Receptor Type 2) is a Protein Coding gene. Diseases associated with PTPN2 include polyarticular onset juvenile idiopathic arthritis and oligoarticular juvenile arthritis. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include protein kinase binding and integrin binding. An important paralog of this gene is PTPN6.

UniProtKB/Swiss-Prot for PTPN2 Gene

  • Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. Finally, it negatively regulates prolactin-mediated signaling pathway through dephosphorylation of STAT5A and STAT5B. May also bind DNA.

Gene Wiki entry for PTPN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN2 Gene

Genomics for PTPN2 Gene

Regulatory Elements for PTPN2 Gene

Genomic Location for PTPN2 Gene

Chromosome:
18
Start:
12,785,478 bp from pter
End:
12,929,643 bp from pter
Size:
144,166 bases
Orientation:
Minus strand

Genomic View for PTPN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN2 Gene

Proteins for PTPN2 Gene

  • Protein details for PTPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17706-PTN2_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 2
    Protein Accession:
    P17706
    Secondary Accessions:
    • A8K955
    • A8MXU3
    • K7ENG3
    • Q96AU5
    • Q96HR2

    Protein attributes for PTPN2 Gene

    Size:
    415 amino acids
    Molecular mass:
    48473 Da
    Quaternary structure:
    • Interacts with RMDN3. Isoform 1 interacts with TMED9. Isoform 1 interacts with STX17; dephosphorylates STX17. Interacts with ITGA1 (via cytoplasmic domain); activates the phosphatase activity towards EGFR. Interacts with TRAF2; probably involved in tumor necrosis factor-mediated signaling. Interacts with MET.

    Three dimensional structures from OCA and Proteopedia for PTPN2 Gene

    Alternative splice isoforms for PTPN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPN2 Gene

Proteomics data for PTPN2 Gene at MOPED

Selected DME Specific Peptides for PTPN2 Gene

Post-translational modifications for PTPN2 Gene

  • Isoform 2: Specifically phosphorylated in a cell cycle-dependent manner by cyclin-dependent kinases. Probably activated through phosphorylation by PKR.
  • Ubiquitination at Lys 60 and Lys 336
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTPN2 (PTPN2 iso2)

Domains & Families for PTPN2 Gene

Gene Families for PTPN2 Gene

Graphical View of Domain Structure for InterPro Entry

P17706

UniProtKB/Swiss-Prot:

PTN2_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
genes like me logo Genes that share domains with PTPN2: view

Function for PTPN2 Gene

Molecular function for PTPN2 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,non receptor type 2,T-cell
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.48 mM for p-nitrophenyl phosphate (at pH 6.5 and 25 degrees Celsius) {ECO:0000269 PubMed:11907034};
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. Finally, it negatively regulates prolactin-mediated signaling pathway through dephosphorylation of STAT5A and STAT5B. May also bind DNA.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL4/interleukin-4 (at protein level).

Enzyme Numbers (IUBMB) for PTPN2 Gene

Gene Ontology (GO) - Molecular Function for PTPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IMP 11909529
GO:0005178 integrin binding IPI 15592458
GO:0005515 protein binding IPI 12359225
GO:0016791 phosphatase activity --
GO:0019901 protein kinase binding IPI 11909529
genes like me logo Genes that share ontologies with PTPN2: view
genes like me logo Genes that share phenotypes with PTPN2: view

Animal Models for PTPN2 Gene

MGI Knock Outs for PTPN2:

Animal Model Products

miRNA for PTPN2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PTPN2 Gene

Localization for PTPN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN2 Gene

Isoform 1: Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region. {ECO:0000269 PubMed:7593185}.
Isoform 2: Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localizes to chromatin (By similarity). Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors (PubMed:9488479). Recruited by activated ITGA1 at the plasma membrane. {ECO:0000250, ECO:0000269 PubMed:9488479}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPN2 Gene COMPARTMENTS Subcellular localization image for PTPN2 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PTPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 7593185
GO:0005654 nucleoplasm TAS --
GO:0005783 endoplasmic reticulum IDA 7593185
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 23006999
GO:0005886 colocalizes_with plasma membrane IDA 15592458
genes like me logo Genes that share ontologies with PTPN2: view

Pathways & Interactions for PTPN2 Gene

genes like me logo Genes that share pathways with PTPN2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for PTPN2 Gene

Activates:
Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for PTPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0008285 negative regulation of cell proliferation IMP 15592458
GO:0008286 insulin receptor signaling pathway ISS --
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway ISS --
GO:0010888 negative regulation of lipid storage ISS --
genes like me logo Genes that share ontologies with PTPN2: view

Drugs & Compounds for PTPN2 Gene

(6) Drugs for PTPN2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
imatinib Approved Pharma Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 567
alanine Nutra 97
arginine Nutra 346
serine Nutra 420
threonine Nutra 16

(5) Additional Compounds for PTPN2 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Phosphotyrosine
TC-48
genes like me logo Genes that share compounds with PTPN2: view

Transcripts for PTPN2 Gene

Unigene Clusters for PTPN2 Gene

Protein tyrosine phosphatase, non-receptor type 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN2 Gene

No ASD Table

Relevant External Links for PTPN2 Gene

GeneLoc Exon Structure for
PTPN2
ECgene alternative splicing isoforms for
PTPN2

Expression for PTPN2 Gene

mRNA expression in normal human tissues for PTPN2 Gene

Protein differential expression in normal tissues from HIPED for PTPN2 Gene

This gene is overexpressed in Breast (22.4), Cerebrospinal fluid (18.2), and Pancreatic juice (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN2 Gene



SOURCE GeneReport for Unigene cluster for PTPN2 Gene Hs.654527

mRNA Expression by UniProt/SwissProt for PTPN2 Gene

P17706-PTN2_HUMAN
Tissue specificity: Ubiquitously expressed. Isoform 2 is probably the major isoform. Isoform 1 is expressed in T-cells and in placenta.
genes like me logo Genes that share expression patterns with PTPN2: view

Protein tissue co-expression partners for PTPN2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PTPN2 Gene

Orthologs for PTPN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPN2 35
  • 87.05 (n)
  • 90.03 (a)
PTPN2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPN2 35
  • 93.09 (n)
  • 93.49 (a)
PTPN2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpn2 35
  • 88.92 (n)
  • 90.64 (a)
Ptpn2 16
Ptpn2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPN2 35
  • 99.56 (n)
  • 99.21 (a)
PTPN2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpn2 35
  • 88.8 (n)
  • 91.88 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPN2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPN2 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPN2 35
  • 77.95 (n)
  • 79 (a)
PTPN2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPN2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn2 35
  • 68.8 (n)
  • 70.47 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ptpn2b 35
  • 66.58 (n)
  • 66.13 (a)
ptpn2a 36
  • 60 (a)
OneToMany
ptpn2b 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ptp61F 37
  • 46 (a)
Ptp61F 35
  • 55.31 (n)
  • 52.59 (a)
Ptp61F 36
  • 31 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005352 35
  • 53.64 (n)
  • 54.02 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK484.7 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for PTPN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN2 Gene

ENSEMBL:
Gene Tree for PTPN2 (if available)
TreeFam:
Gene Tree for PTPN2 (if available)

Paralogs for PTPN2 Gene

Pseudogenes.org Pseudogenes for PTPN2 Gene

genes like me logo Genes that share paralogs with PTPN2: view

Variants for PTPN2 Gene

Sequence variations from dbSNP and Humsavar for PTPN2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs471401 -- 12,858,322(-) AGCAT(A/G)TTTCC intron-variant
rs478582 -- 12,835,977(+) TGACG(C/T)AGTAT intron-variant
rs482154 -- 12,855,650(-) CCACC(C/G)TGTTC intron-variant
rs482160 -- 12,855,647(-) CCGTG(C/T)TCCAG intron-variant
rs482908 -- 12,855,624(-) TAAAT(C/T)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPN2 Gene

Variant ID Type Subtype PubMed ID
esv3172 CNV Deletion 18987735
esv2716815 CNV Deletion 23290073
nsv130834 CNV Loss 16902084
nsv131711 CNV Insertion 16902084
nsv909407 CNV Loss 21882294

Variation tolerance for PTPN2 Gene

Residual Variation Intolerance Score: 78.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPN2 Gene

HapMap Linkage Disequilibrium report
PTPN2
Human Gene Mutation Database (HGMD)
PTPN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN2 Gene

Disorders for PTPN2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for PTPN2 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
polyarticular onset juvenile idiopathic arthritis
  • juvenile polyarthritis rheumatoid factor negative
oligoarticular juvenile arthritis
  • pauciarticular chronic arthritis
anonychia congenita
  • hyponychia congenita
bubonic plague
  • black death
crohn's disease
  • enteritis
- elite association
Search PTPN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPN2

Genetic Association Database (GAD)
PTPN2
Human Genome Epidemiology (HuGE) Navigator
PTPN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPN2
genes like me logo Genes that share disorders with PTPN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPN2 Gene

Publications for PTPN2 Gene

  1. Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells. (PMID: 19922411) Omerovic J. … Prior I.A. (Biochem. J. 2010) 23 67
  2. Enhancement of insulin responsiveness by nitric oxide-mediated inactivation of protein-tyrosine phosphatases. (PMID: 20064934) Hsu M.F. … Meng T.C. (J. Biol. Chem. 2010) 23 67
  3. Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity. (PMID: 20153651) Ye D. … Liu H. (Bioorg. Med. Chem. 2010) 23 67
  4. [Research progress of several protein tyrosine phosphatases in diabetes]. (PMID: 20401454) Chen M. … Yu X. (Sheng Li Xue Bao 2010) 23 67
  5. Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. (PMID: 20473312) Kleppe M. … Cools J. (Nat. Genet. 2010) 23 67

Products for PTPN2 Gene

Sources for PTPN2 Gene

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