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PTPN18 Gene

protein-coding   GIFtS: 62
GCID: GC02P131113

Protein Tyrosine Phosphatase, Non-Receptor Type 18 (Brain-Derived)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 18 (Brain-Derived)1 2
BDP12 3 5
Brain-Derived Phosphatase2 3
EC 3.1.3.483 8
PTP-HSCF2
Tyrosine-Protein Phosphatase Non-Receptor Type 182

External Ids:    HGNC: 96491   Entrez Gene: 264692   Ensembl: ENSG000000721357   OMIM: 6065875   UniProtKB: Q999523   

Export aliases for PTPN18 gene to outside databases

Previous GC identifers: GC02M128348 GC02M129897 GC02P131018 GC02P131206 GC02P130829 GC02P123403


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPN18 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the
mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a
protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can
differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and
it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine
kinases. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,
Nov 2008)

GeneCards Summary for PTPN18 Gene:
PTPN18 (protein tyrosine phosphatase, non-receptor type 18 (brain-derived)) is a protein-coding gene. GO annotations related to this gene include non-membrane spanning protein tyrosine phosphatase activity. An important paralog of this gene is PTPN1.

UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952
Function: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed
in tumor tissues

Gene Wiki entry for PTPN18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PTPN18 gene promoter:
         SRF   MAZR   SRF (504 AA)   MyoD   MIF-1   CREB   PPAR-alpha   deltaCREB   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN18 promoter sequence
   Search Chromatin IP Primers for PTPN18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21

PTPN18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN18 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P131113:  view genomic region     (about GC identifiers)

Start:
131,113,580 bp from pter      End:
131,132,982 bp from pter
Size:
19,403 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 18  
Size: 460 amino acids; 50482 Da
Subunit: Interacts with PSTPIP1 (By similarity)
3 PDB 3D structures from and Proteopedia for PTPN18:
2OC3 (3D)        4GFU (3D)        4GFV (3D)    
Secondary accessions: B4E1E6 Q53P42
Alternative splicing: 2 isoforms:  Q99952-1   Q99952-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPN18: NX_Q99952

Explore proteomics data for PTPN18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for PTPN18 (Q99952)
     VQTEEQY  YIATQGP 


    See PTPN18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135842.1  NP_055184.2  

    ENSEMBL proteins: 
     ENSP00000175756   ENSP00000310092   ENSP00000411750   ENSP00000387031  

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    antibodies-online peptides for PTPN18

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    3 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry Q99952

    ProtoNet protein and cluster: Q99952

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPN18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN18_HUMAN, Q99952
    Function: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed
    in tumor tissues
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN18:
    protein tyrosine phosphatase,non-receptor type 18,expressed in brain,colon and several tumor-derived cell lines

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0004726non-membrane spanning protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI9422760
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with PTPN18           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PTPN18:
     Decreased cell spreading  Increased Erk phosphorylation  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PTPN18

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    miRTarBase miRNAs that target PTPN18:
    hsa-mir-16-5p (MIRT051290)

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    6 qRT-PCR Assays for microRNAs that regulate PTPN18:
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-640 hsa-miR-125b hsa-miR-4251 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidPTPN18 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTN18_HUMAN, Q99952: Nucleus (By similarity). Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with PTPN18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPN18 About    
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2Protein Stability
    Protein Stability
    3Phosphatases
    Phosphatases
    4B Cell Receptor Signaling Pathway (WikiPathways)
    B Cell Receptor Signaling Pathway


    Find genes that share SuperPaths with PTPN18           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPN18
        Epithelial Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for PTPN18
        Phosphatases
    Protein Stability

    1 BioSystems Pathway for PTPN18
        B Cell Receptor Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PTPN18
    Interactions:

        Search GeneGlobe Interaction Network for PTPN18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTPN18 (Q999521, 2, 3 ENSP000001757564) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSTPIP1O435861, 2, 3, ENSP000003689144EBI-1384210,EBI-1050964 MINT-8254936 MINT-8254395 MINT-8254762 MINT-8255095 I2D: score=4 STRING: ENSP00000368914
    TECP426803, ENSP000003709124I2D: score=3 STRING: ENSP00000370912
    ABL1P005193, ENSP000003614234I2D: score=2 STRING: ENSP00000361423
    ARHGAP5Q130173, ENSP000003718974I2D: score=2 STRING: ENSP00000371897
    CSKP412403, ENSP000002200034I2D: score=2 STRING: ENSP00000220003
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS8950995
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS8950995

    Find genes that share ontologies with PTPN18           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for PTPN18 (PTN18)

    2 HMDB Compounds for PTPN18    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTPN18 gene (2 alternative transcripts): 
    NM_001142370.1  NM_014369.3  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000175756(uc002trc.3 uc002trb.3 uc002tre.3) ENST00000347849
    ENST00000489215 ENST00000428843 ENST00000420717 ENST00000483617 ENST00000479295
    ENST00000460992 ENST00000495400 ENST00000409022 ENST00000490812 ENST00000462996
    ENST00000464576 ENST00000490137 ENST00000481492 ENST00000462321
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    6 qRT-PCR Assays for microRNAs that regulate PTPN18:
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-640 hsa-miR-125b hsa-miR-4251 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidPTPN18 3' UTR sequence
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    Selected AceView cDNA sequences (see all 284):

    AI810663 BE793556 BU619831 BX107629 CK822863 CR616748 BU507872 BQ894464 
    AW148696 BF903485 AA235326 CA310199 CA390912 BM724913 BM916955 AW674541 
    BQ086140 BE327745 AW574769 CA427181 CD672483 AA524210 AA809133 AW204520 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTPN18 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16 ^
    SP1:                                                                    -                                                                                       
    SP2:                                                                                                                                                            
    SP3:                    -                                                                                                                                       
    SP4:                    -     -     -     -     -                                                                                                               
    SP5:                                                                                                              -     -     -                                 

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for PTPN18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPN18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAAGTGAC
    PTPN18 Expression
    About this image


    PTPN18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PTPN18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPN18 Protein Expression

    UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952
    Tissue specificity: Expressed in brain, colon and several tumor-derived cell lines

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTPN18 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn181 , 5 protein tyrosine phosphatase, non-receptor type 181, 5 80.9(n)1
    77.21(a)1
      1 (13.25 cM)5
    192531  NM_011206.21  NP_035336.21 
     344597465 
    chicken
    (Gallus gallus)
    Aves --
    Gallus gallus protein tyrosine phosphatase, non-re...
    18(a)
    many ↔ many
    21(2679190-2699394) ENSGALG00000002005
    lizard
    (Anolis carolinensis)
    Reptilia PTPN186
    protein tyrosine phosphatase, non-receptor type 18...
    46(a)
    1 ↔ 1
    2(69014328-69082839)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017306991 tyrosine-protein phosphatase non-receptor type 18-like 61.87(n)
    52.14(a)
      101730699  XM_004920611.1  XP_004920668.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ptpn181 protein tyrosine phosphatase, non-receptor type 18 52.48(n)
    45.72(a)
      541324  NM_001013452.1  NP_001013470.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C17H12.33 protein-tyrosine phosphatase 34(a)   IV(6794148-6795367)   --


    ENSEMBL Gene Tree for PTPN18 (if available)
    TreeFam Gene Tree for PTPN18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPN18 gene
    PTPN12  PTPN222  PTPN112  PTPN92  PTPN62  PTPRN22  PTPRN2  PTPN142  
    PTPN212  PTPN20B2  PTPN22  PTPN122  PTPN20A2  
    5 SIMAP similar genes for PTPN18 using alignment to 3 protein entries:     PTN18_HUMAN (see all proteins):
    PTP    PTPN22    PTPN12    PTPRH    DKFZp781C1038

    Find genes that share paralogs with PTPN18           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPN18 (see all 540)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1162086971,2
    C,F--131111650(+) ACAGGT/CGCCCT 2 -- us2k11Minor allele frequency- C:0.06WA 118
    rs1922461741,2
    --131111679(+) CATTAC/TCCCAG 2 -- us2k10--------
    rs577988871,2
    C,F--131111788(+) AACAGG/TATCCC 2 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1857907321,2
    C--131111813(+) GATCCC/TCTAGC 2 -- us2k10--------
    rs1416070701,2
    C--131111894(+) CTGAAA/CGCTTA 2 -- us2k10--------
    rs729883071,2
    C,F--131111962(+) GATTAT/CACTGA 2 -- us2k13Minor allele frequency- C:0.09WA NA 240
    rs58342851,2
    C--131112128(-) GGGGG-/GTGTCA 2 -- us2k1 tfbs3 trp30--------
    rs351393771,2
    C--131112129(+) GACAC-/C/    
       CC
    /GC
    CCCCC
    2 -- us2k10--------
    rs1894413211,2
    --131112135(+) CCCCCC/TCCCCA 2 -- us2k10--------
    rs1144186021,2
    C,F--131112197(+) ATCCTA/GAACAA 2 -- us2k11Minor allele frequency- G:0.03NA 120

    HapMap Linkage Disequilibrium report for PTPN18 (131113580 - 131132982 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTPN18 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv459274CNV Loss19166990
    nsv428403CNV Loss18775914
    nsv875097CNV Loss21882294
    nsv459341CNV Loss19166990
    nsv875102CNV Gain21882294
    dgv4306n71CNV Gain21882294
    dgv4309n71CNV Gain21882294
    dgv475n27CNV Gain19166990
    dgv4305n71CNV Gain21882294
    dgv4308n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTPN18
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPN18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606587    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PTPN18:
    Pyoderma gangrenosum

    Find genes that share disorders with PTPN18           About GenesLikeMe


    Export disorders for PTPN18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPN18 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with PTPN18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the PEST family protein tyrosine phosphatase BDP1. (PubMed id 8950995)1, 2, 3, 9 Kim Y.W.... Ullrich A. (Oncogene 1996)
    2. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    3. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (Nat. Biotechnol. 2011)
    4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    5. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)2 Barr A.J.... Knapp S. (Cell 2009)
    6. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)1 Zhang Y.... White F.M. (Mol. Cell. Proteomics 2005)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    8. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    9. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)1 Tao W.A....Aebersold R. (Nat. Methods 2005)
    10. Substrate-trapping techniques in the identification of cellular PTP targets. (PubMed id 15588985)1 Blanchetot C....Tremblay M.L. (Methods 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26469 HGNC: 9649 AceView: PTPN18 Ensembl:ENSG00000072135 euGenes: HUgn26469
    ECgene: PTPN18 H-InvDB: PTPN18

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPN18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPN18 gene:
    Search GeneIP for patents involving PTPN18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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