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Aliases for PTPN18 Gene

Aliases for PTPN18 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 18 (Brain-Derived) 2 3
  • BDP1 3 4 6
  • Brain-Derived Phosphatase 3 4
  • EC 4 63
  • Tyrosine-Protein Phosphatase Non-Receptor Type 18 3
  • PTP-HSCF 3

External Ids for PTPN18 Gene

Previous GeneCards Identifiers for PTPN18 Gene

  • GC02M128348
  • GC02M129897
  • GC02P131018
  • GC02P131206
  • GC02P130829
  • GC02P131113
  • GC02P123403

Summaries for PTPN18 Gene

Entrez Gene Summary for PTPN18 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for PTPN18 Gene

PTPN18 (Protein Tyrosine Phosphatase, Non-Receptor Type 18 (Brain-Derived)) is a Protein Coding gene. Among its related pathways are PAK Pathway and B Cell Receptor Signaling Pathway (WikiPathways). GO annotations related to this gene include non-membrane spanning protein tyrosine phosphatase activity. An important paralog of this gene is PTPN6.

UniProtKB/Swiss-Prot for PTPN18 Gene

  • Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues

Gene Wiki entry for PTPN18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN18 Gene

Genomics for PTPN18 Gene

Regulatory Elements for PTPN18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPN18 Gene

130,356,007 bp from pter
130,375,409 bp from pter
19,403 bases
Plus strand

Genomic View for PTPN18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN18 Gene

Proteins for PTPN18 Gene

  • Protein details for PTPN18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 18
    Protein Accession:
    Secondary Accessions:
    • B4E1E6
    • Q53P42

    Protein attributes for PTPN18 Gene

    460 amino acids
    Molecular mass:
    50482 Da
    Quaternary structure:
    • Interacts with PSTPIP1.

    Three dimensional structures from OCA and Proteopedia for PTPN18 Gene

    Alternative splice isoforms for PTPN18 Gene


neXtProt entry for PTPN18 Gene

Proteomics data for PTPN18 Gene at MOPED

Selected DME Specific Peptides for PTPN18 Gene

Post-translational modifications for PTPN18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPN18 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTPN18 (BDP1)

Domains for PTPN18 Gene

Gene Families for PTPN18 Gene

  • PTPN :Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

Graphical View of Domain Structure for InterPro Entry



  • Q99952
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
genes like me logo Genes that share domains with PTPN18: view

Function for PTPN18 Gene

Molecular function for PTPN18 Gene

GENATLAS Biochemistry: protein tyrosine phosphatase,non-receptor type 18,expressed in brain,colon and several tumor-derived cell lines
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues

Enzyme Numbers (IUBMB) for PTPN18 Gene

Gene Ontology (GO) - Molecular Function for PTPN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity --
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 9422760
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPN18: view

Phenotypes for PTPN18 Gene

genes like me logo Genes that share phenotypes with PTPN18: view

Animal Model Products

CRISPR Products

miRNA for PTPN18 Gene

miRTarBase miRNAs that target PTPN18

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PTPN18 Gene

Localization for PTPN18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN18 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for PTPN18 Gene COMPARTMENTS Subcellular localization image for PTPN18 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PTPN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PTPN18: view

Pathways for PTPN18 Gene

genes like me logo Genes that share pathways with PTPN18: view

Gene Ontology (GO) - Biological Process for PTPN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 8950995
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 8950995
genes like me logo Genes that share ontologies with PTPN18: view

Compounds for PTPN18 Gene

(2) HMDB Compounds for PTPN18 Gene

Compound Synonyms Cas Number PubMed IDs
  • NFB Orthophosphate
  • Dihydrogen oxide
genes like me logo Genes that share compounds with PTPN18: view

Transcripts for PTPN18 Gene

Unigene Clusters for PTPN18 Gene

Protein tyrosine phosphatase, non-receptor type 18 (brain-derived):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN18

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN18 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16 ^
SP1: -
SP3: -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - -

ExUns: 17

Relevant External Links for PTPN18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPN18 Gene

mRNA expression in normal human tissues for PTPN18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPN18 Gene

This gene is overexpressed in Whole Blood (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN18 Gene

SOURCE GeneReport for Unigene cluster for PTPN18 Gene Hs.744861

mRNA Expression by UniProt/SwissProt for PTPN18 Gene

Tissue specificity: Expressed in brain, colon and several tumor-derived cell lines.
genes like me logo Genes that share expressions with PTPN18: view

In Situ Assay Products

Orthologs for PTPN18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPN18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTPN18 35
  • 98.31 (n)
  • 96.92 (a)
PTPN18 36
  • 97 (a)
(Bos Taurus)
Mammalia PTPN18 35
  • 84.57 (n)
  • 82.97 (a)
PTPN18 36
  • 80 (a)
(Canis familiaris)
Mammalia PTPN18 35
  • 78.8 (n)
  • 73.59 (a)
PTPN18 36
  • 72 (a)
(Mus musculus)
Mammalia Ptpn18 35
  • 80.9 (n)
  • 77.21 (a)
Ptpn18 16
Ptpn18 36
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
(Ornithorhynchus anatinus)
Mammalia PTPN18 36
  • 50 (a)
(Rattus norvegicus)
Mammalia Ptpn18 35
  • 78.98 (n)
  • 75.66 (a)
(Gallus gallus)
Aves -- 36
  • 18 (a)
(Anolis carolinensis)
Reptilia PTPN18 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730699 35
  • 61.87 (n)
  • 52.14 (a)
(Danio rerio)
Actinopterygii ptpn18 35
  • 52.48 (n)
  • 45.72 (a)
ptpn18 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea Y41D4A.5 36
  • 21 (a)
C17H12.3 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTP3 38
Species with no ortholog for PTPN18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN18 Gene

Gene Tree for PTPN18 (if available)
Gene Tree for PTPN18 (if available)

Paralogs for PTPN18 Gene

Selected SIMAP similar genes for PTPN18 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PTPN18: view

Variants for PTPN18 Gene

Sequence variations from dbSNP and Humsavar for PTPN18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1043679 -- 130,370,205(+) ATGGG(C/T)TTCAG intron-variant
rs1127363 -- 130,375,375(-) cacag(G/T)gaaca utr-variant-3-prime
rs1518289 -- 130,370,377(-) GAGCA(A/G)GAGCT intron-variant
rs1518290 -- 130,370,376(-) AGCAA(C/G)AGCTG intron-variant
rs1533565 -- 130,370,925(-) TGGAG(C/T)GTGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PTPN18 Gene

Variant ID Type Subtype PubMed ID
nsv459274 CNV Loss 19166990
dgv1247e1 CNV Complex 17122850
esv2751826 CNV Gain 17911159
dgv1250e1 CNV Complex 17122850
nsv428403 CNV Loss 18775914
dgv4305n71 CNV Gain 21882294
dgv4306n71 CNV Gain 21882294
nsv7327 OTHER Inversion 18451855
dgv4307n71 CNV Gain 21882294
nsv520559 CNV Gain+Loss 19592680
nsv875084 CNV Gain+Loss 21882294
dgv4308n71 CNV Gain 21882294
dgv475n27 CNV Gain 19166990
essv2399 CNV CNV 17122850
dgv4309n71 CNV Gain 21882294
nsv459341 CNV Loss 19166990
nsv875097 CNV Loss 21882294
nsv875098 CNV Gain 21882294
dgv4310n71 CNV Gain 21882294
nsv875102 CNV Gain 21882294

Relevant External Links for PTPN18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN18 Gene

Disorders for PTPN18 Gene

(1) University of Copenhagen DISEASES for PTPN18 Gene

genes like me logo Genes that share disorders with PTPN18: view

No data available for UniProtKB/Swiss-Prot for PTPN18 Gene

Publications for PTPN18 Gene

  1. Characterization of the PEST family protein tyrosine phosphatase BDP1. (PMID: 8950995) Kim Y.W. … Ullrich A. (Oncogene 1996) 2 3 4 23
  2. Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue binding phosphatases. (PMID: 10685610) Cheng L.Y. … Iqbal K. (Neurochem. Res. 2000) 23
  3. GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA. (PMID: 12974676) Liu Q.-R. … Uhl G.R. (Biochem. J. 2004) 23
  4. PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase. (PMID: 9265651) Spencer S. … Lasky L.A. (J. Cell Biol. 1997) 3
  5. Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein. (PMID: 9422760) Dowbenko D. … Lasky L.A. (J. Biol. Chem. 1998) 3

Products for PTPN18 Gene

Sources for PTPN18 Gene

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