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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPN18 Gene

protein-coding   GIFtS: 65
GCID: GC02P131113

Protein Tyrosine Phosphatase, Non-Receptor Type 18 (Brain-Derived)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 18 (Brain-Derived)1 2
BDP12 3 5
Brain-Derived Phosphatase2 3
EC 3.1.3.483 8
PTP-HSCF2
Tyrosine-Protein Phosphatase Non-Receptor Type 182

External Ids:    HGNC: 96491   Entrez Gene: 264692   Ensembl: ENSG000000721357   OMIM: 6065875   UniProtKB: Q999523   

Export aliases for PTPN18 gene to outside databases

Previous GC identifers: GC02M128348 GC02M129897 GC02P131018 GC02P131206 GC02P130829 GC02P123403


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPN18 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the
mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a
protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can
differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and
it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine
kinases. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,
Nov 2008)

GeneCards Summary for PTPN18 Gene: 
PTPN18 (protein tyrosine phosphatase, non-receptor type 18 (brain-derived)) is a protein-coding gene. Diseases associated with PTPN18 include pyoderma, and pyoderma gangrenosum, and among its related super-pathways are PAK Pathway. GO annotations related to this gene include non-membrane spanning protein tyrosine phosphatase activity. An important paralog of this gene is PTPN1.

UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952
Function: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed
in tumor tissues

Gene Wiki entry for PTPN18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPN18 gene promoter:
         SRF   MAZR   SRF (504 AA)   MyoD   MIF-1   CREB   PPAR-alpha   deltaCREB   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN18 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPN18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21

PTPN18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN18 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P131113:  view genomic region     (about GC identifiers)

Start:
131,113,580 bp from pter      End:
131,132,982 bp from pter
Size:
19,403 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 18  
Size: 460 amino acids; 50482 Da
Subunit: Interacts with PSTPIP1 (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity)
1 PDB 3D structure from and Proteopedia for PTPN18:
2OC3 (3D)    
Secondary accessions: B4E1E6 Q53P42
Alternative splicing: 2 isoforms:  Q99952-1   Q99952-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPN18: NX_Q99952

Explore proteomics data for PTPN18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99952

  • 2 DME Specific Peptides for PTPN18 (Q99952)
     VQTEEQY  YIATQGP 

    PTPN18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTPN18 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001135842.1  NP_055184.2  

    ENSEMBL proteins: 
     ENSP00000175756   ENSP00000310092   ENSP00000411750   ENSP00000387031  

    Human Recombinant Protein Products for PTPN18: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for PTPN18 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    PTPN18 for ontologies           About GeneDecksing



    PTPN18 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    3 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry Q99952

    ProtoNet protein and cluster: Q99952

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    PTPN18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN18_HUMAN, Q99952
    Function: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed
    in tumor tissues
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN18:
    protein tyrosine phosphatase,non-receptor type 18,expressed in brain,colon and several tumor-derived cell lines

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0004726non-membrane spanning protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI9422760
    GO:0016791phosphatase activity ----
         
    PTPN18 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PTPN18:
     Decreased cell spreading  Increased Erk phosphorylation  

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidPTPN18 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN18


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTPN18 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2Protein Stability
    Protein Stability
    3B Cell Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway
    4Phosphatases
    Phosphatases

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPN18
        Epithelial Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for PTPN18
        Phosphatases
    Protein Stability

    1 BioSystems Pathway for PTPN18
        B Cell Receptor Signaling Pathway



    PTPN18 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PTPN18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for PTPN18 (Q999522, 3 ENSP000001757564) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSTPIP1O435862, 3, ENSP000003689144MINT-8254936 MINT-8254395 MINT-8254762 MINT-8255095 I2D: score=4 STRING: ENSP00000368914
    TECP426803, ENSP000003709124I2D: score=3 STRING: ENSP00000370912
    ABL1P005193, ENSP000003614234I2D: score=2 STRING: ENSP00000361423
    ARHGAP5Q130173, ENSP000003718974I2D: score=2 STRING: ENSP00000371897
    CSKP412403, ENSP000002200034I2D: score=2 STRING: ENSP00000220003
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS8950995
    GO:0016311dephosphorylation ----

    PTPN18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PTPN18:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPN18 (PTN18)

    2 HMDB Compounds for PTPN18    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about PTPN18 / PTN18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTPN18 gene (2 alternative transcripts): 
    NM_001142370.1  NM_014369.3  

    Unigene Cluster for PTPN18:

    Protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
    Hs.744861  [show with all ESTs]
    Unigene Representative Sequence: NM_014369
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000175756(uc002trc.3 uc002trb.3 uc002tre.3) ENST00000347849
    ENST00000489215 ENST00000428843 ENST00000420717 ENST00000483617 ENST00000479295
    ENST00000460992 ENST00000495400 ENST00000409022 ENST00000490812 ENST00000462996
    ENST00000464576 ENST00000490137 ENST00000481492 ENST00000462321
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN18:
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-640 hsa-miR-125b hsa-miR-4251 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidPTPN18 3' UTR sequence
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN18

    Additional mRNA sequence: 

    AK297884.1 AK303804.1 BC024280.1 BC041562.1 BC052800.1 X79568.1 

    24/27 DOTS entries (see all 27):

    DT.100751707  DT.92455428  DT.415969  DT.97859241  DT.100775592  DT.92455407  DT.91875410  DT.120981520 
    DT.429645  DT.95313577  DT.306615  DT.95306663  DT.100746051  DT.91700098  DT.91860968  DT.92455403 
    DT.95306684  DT.95343851  DT.120980897  DT.120981444  DT.100733576  DT.121610570  DT.40282072  DT.86853207 

    24/284 AceView cDNA sequences (see all 284):

    BM473903 BQ227706 BU619831 AA768972 AA775582 CD672484 BF903485 AI810663 
    AA323185 BU859900 BQ061600 BM695240 BE793556 CA390912 BE327745 BM916955 
    AI445719 BQ086140 CA427181 CR616748 BQ894464 BU537921 AA568882 BU507872 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN18 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16 ^
    SP1:                                                                    -                                                                                       
    SP2:                                                                                                                                                            
    SP3:                    -                                                                                                                                       
    SP4:                    -     -     -     -     -                                                                                                               
    SP5:                                                                                                              -     -     -                                 

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for PTPN18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPN18 expression in normal human tissues (normalized intensities)      PTPN18 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAAGTGAC
    PTPN18 Expression
    About this image


    PTPN18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             platelets   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See PTPN18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPN18

    SOURCE GeneReport for Unigene cluster: Hs.744861

    UniProtKB/Swiss-Prot: PTN18_HUMAN, Q99952
    Tissue specificity: Expressed in brain, colon and several tumor-derived cell lines

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PTPN18 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn181 , 5 protein tyrosine phosphatase, non-receptor type 181, 5 80.75(n)1
    77.43(a)1
      1 (13.25 cM)5
    192531  NM_011206.21  NP_035336.21 
     344597465 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN186
    protein tyrosine phosphatase, non-receptor type 18...
    45(a)
    1 ↔ 1
    2(69014328-69082839)
    zebrafish
    (Danio rerio)
    Actinopterygii ptpn181 protein tyrosine phosphatase, non-receptor type 18 52.03(n)
    45.5(a)
      541324  NM_001013452.1  NP_001013470.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423276
    PTP-ER6
    Protein tyrosine phosphatase-ERK/Enhancer of Ras1
    7(a)
    6(a)
    1 ↔ many
    possible ortholog
    3R(7481875-7499697)
    2R(17506889-17511947)


    ENSEMBL Gene Tree for PTPN18 (if available)
    TreeFam Gene Tree for PTPN18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPN18 gene
    PTPN12  PTPRH2  PTPN222  PTPRO2  PTPN112  PTPN92  PTPN62  PTPRQ2  
    PTPRJ2  PTPN122  PTPN22  PTPRB2  
    5 SIMAP similar genes for PTPN18 using alignment to 3 protein entries:     PTN18_HUMAN (see all proteins):
    PTP    PTPN22    PTPN12    PTPRH    DKFZp781C1038

    PTPN18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/540 SNPs in PTPN18 are shown (see all 540)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1162086971,2
    C,F--131111650(+) ACAGGT/CGCCCT 2 -- us2k11Minor allele frequency- C:0.06WA 118
    rs1922461741,2
    --131111679(+) CATTAC/TCCCAG 2 -- us2k10--------
    rs577988871,2
    C,F--131111788(+) AACAGG/TATCCC 2 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1857907321,2
    C--131111813(+) GATCCC/TCTAGC 2 -- us2k10--------
    rs1416070701,2
    C--131111894(+) CTGAAA/CGCTTA 2 -- us2k10--------
    rs729883071,2
    C,F--131111962(+) GATTAT/CACTGA 2 -- us2k13Minor allele frequency- C:0.09WA NA 240
    rs58342851,2
    C--131112128(-) GGGGG-/GTGTCA 2 -- us2k1 tfbs3 trp30--------
    rs351393771,2
    C--131112129(+) GACAC-/C/    
       CC
    /GC
    CCCCC
    2 -- us2k10--------
    rs1894413211,2
    --131112135(+) CCCCCC/TCCCCA 2 -- us2k10--------
    rs1144186021,2
    C,F--131112197(+) ATCCTA/GAACAA 2 -- us2k11Minor allele frequency- G:0.03NA 120

    HapMap Linkage Disequilibrium report for PTPN18 (131113580 - 131132982 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for PTPN18 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv459274CNV Loss19166990
    nsv428403CNV Loss18775914
    nsv875097CNV Loss21882294
    nsv459341CNV Loss19166990
    nsv875102CNV Gain21882294
    dgv4306n71CNV Gain21882294
    dgv4309n71CNV Gain21882294
    dgv475n27CNV Gain19166990
    dgv4305n71CNV Gain21882294
    dgv4308n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606587    OMIM disorders: --

    3 diseases for PTPN18:    About MalaCards
    pyoderma    pyoderma gangrenosum    gastric cancer

    1 disease from the University of Copenhagen DISEASES database for PTPN18:
    Pyoderma gangrenosum

    PTPN18 for disorders           About GeneDecksing


    Export disorders for PTPN18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPN18 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with PTPN18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the PEST family protein tyrosine phosphatase BDP1. (PubMed id 8950995)1, 2, 3, 9 Kim Y.W.... Ullrich A. (1996)
    2. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (2011)
    3. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    4. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)2 Barr A.J.... Knapp S. (2009)
    5. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)1 Zhang Y.... White F.M. (2005)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    7. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    8. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)1 Tao W.A.... Aebersold R. (2005)
    9. Substrate-trapping techniques in the identification of cellular PTP targets. (PubMed id 15588985)1 Blanchetot C....Tremblay M.L. (2005)
    10. A bioinformatics analysis of protein tyrosine phosphatases in humans. (PubMed id 16303740)1 Gandhi T.K....Pandey A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26469 HGNC: 9649 AceView: PTPN18 Ensembl:ENSG00000072135 euGenes: HUgn26469
    ECgene: PTPN18 H-InvDB: PTPN18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPN18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTPN18 gene:
    Search GeneIP for patents involving PTPN18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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