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Aliases for PTPN18 Gene

Aliases for PTPN18 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 18 2 3 5
  • Protein Tyrosine Phosphatase, Non-Receptor Type 18 (Brain-Derived) 2 3
  • Brain-Derived Phosphatase 3 4
  • EC 3.1.3.48 4 61
  • BDP1 3 4
  • Tyrosine-Protein Phosphatase Non-Receptor Type 18 3
  • PTP-HSCF 3

External Ids for PTPN18 Gene

Previous GeneCards Identifiers for PTPN18 Gene

  • GC02M128348
  • GC02M129897
  • GC02P131018
  • GC02P131206
  • GC02P130829
  • GC02P131113
  • GC02P123403

Summaries for PTPN18 Gene

Entrez Gene Summary for PTPN18 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for PTPN18 Gene

PTPN18 (Protein Tyrosine Phosphatase, Non-Receptor Type 18) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by ERBB2. GO annotations related to this gene include phosphatase activity and non-membrane spanning protein tyrosine phosphatase activity. An important paralog of this gene is PTPN12.

UniProtKB/Swiss-Prot for PTPN18 Gene

  • Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

Gene Wiki entry for PTPN18 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN18 Gene

Genomics for PTPN18 Gene

Regulatory Elements for PTPN18 Gene

Enhancers for PTPN18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G130369 1.6 Ensembl ENCODE dbSUPER 34.1 +15.9 15862 4.2 HDGF FOXA2 CREB3L1 ARNT AGO1 SIN3A ZNF2 ZNF766 CBX5 ZNF143 PTPN18 PIR32046
GH02G130354 1.1 ENCODE 32.6 -0.1 -57 2.1 HDGF HNRNPUL1 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 PTPN18 FAR2P1 PIR60541
GH02G130376 1 ENCODE dbSUPER 33.5 +21.1 21119 1.4 CTCF PKNOX1 TBL1XR1 BMI1 EBF1 RAD21 RELA ARID3A EED RELB PTPN18 FAR2P1 PIR49689 PIR32046
GH02G130389 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.1 +35.2 35190 2.8 PKNOX1 FOXA2 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 PTPN18 FAR2P2 AMER3 CCDC115 LOC105373618 PIR36289
GH02G130336 1.4 Ensembl ENCODE 15 -17.7 -17700 3.5 HNRNPUL1 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF766 PTPN18 RAB6C-AS1 IMP4 TRE-TTC1-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTPN18 on UCSC Golden Path with GeneCards custom track

Promoters for PTPN18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000123085 193 1601 HNRNPUL1 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143

Genomic Location for PTPN18 Gene

Chromosome:
2
Start:
130,356,007 bp from pter
End:
130,375,409 bp from pter
Size:
19,403 bases
Orientation:
Plus strand

Genomic View for PTPN18 Gene

Genes around PTPN18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN18 Gene

Proteins for PTPN18 Gene

  • Protein details for PTPN18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99952-PTN18_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 18
    Protein Accession:
    Q99952
    Secondary Accessions:
    • B4E1E6
    • Q53P42

    Protein attributes for PTPN18 Gene

    Size:
    460 amino acids
    Molecular mass:
    50482 Da
    Quaternary structure:
    • Interacts with PSTPIP1.

    Three dimensional structures from OCA and Proteopedia for PTPN18 Gene

    Alternative splice isoforms for PTPN18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPN18 Gene

Selected DME Specific Peptides for PTPN18 Gene

Q99952:
  • VQTEEQY
  • YIATQGP

Post-translational modifications for PTPN18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPN18 Gene

Domains & Families for PTPN18 Gene

Gene Families for PTPN18 Gene

Graphical View of Domain Structure for InterPro Entry

Q99952

UniProtKB/Swiss-Prot:

PTN18_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
genes like me logo Genes that share domains with PTPN18: view

Function for PTPN18 Gene

Molecular function for PTPN18 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,non-receptor type 18,expressed in brain,colon and several tumor-derived cell lines
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

Enzyme Numbers (IUBMB) for PTPN18 Gene

Gene Ontology (GO) - Molecular Function for PTPN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity EXP,IEA 25081058
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS,IEA --
GO:0005515 protein binding IPI 9422760
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTPN18: view
genes like me logo Genes that share phenotypes with PTPN18: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPN18

CRISPR Products

miRNA for PTPN18 Gene

miRTarBase miRNAs that target PTPN18

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTPN18 Gene

Localization for PTPN18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN18 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPN18 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 2
mitochondrion 2
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PTPN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PTPN18: view

Pathways & Interactions for PTPN18 Gene

genes like me logo Genes that share pathways with PTPN18: view

Pathways by source for PTPN18 Gene

1 BioSystems pathway for PTPN18 Gene
1 Qiagen pathway for PTPN18 Gene

Gene Ontology (GO) - Biological Process for PTPN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,TAS 8950995
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0038128 ERBB2 signaling pathway TAS --
GO:1901185 negative regulation of ERBB signaling pathway TAS --
genes like me logo Genes that share ontologies with PTPN18: view

No data available for SIGNOR curated interactions for PTPN18 Gene

Drugs & Compounds for PTPN18 Gene

(2) Drugs for PTPN18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PTPN18 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PTPN18: view

Transcripts for PTPN18 Gene

Unigene Clusters for PTPN18 Gene

Protein tyrosine phosphatase, non-receptor type 18 (brain-derived):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN18 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16 ^
SP1: -
SP2:
SP3: -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - -
SP8:
SP9:

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for PTPN18 Gene

GeneLoc Exon Structure for
PTPN18
ECgene alternative splicing isoforms for
PTPN18

Expression for PTPN18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTPN18 Gene

mRNA differential expression in normal tissues according to GTEx for PTPN18 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for PTPN18 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (39.3) and Monocytes (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTPN18 Gene



NURSA nuclear receptor signaling pathways regulating expression of PTPN18 Gene:

PTPN18

SOURCE GeneReport for Unigene cluster for PTPN18 Gene:

Hs.744861

mRNA Expression by UniProt/SwissProt for PTPN18 Gene:

Q99952-PTN18_HUMAN
Tissue specificity: Expressed in brain, colon and several tumor-derived cell lines.

Evidence on tissue expression from TISSUES for PTPN18 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Intestine(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PTPN18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPN18 Gene

Orthologs for PTPN18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPN18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPN18 34 35
  • 98.31 (n)
cow
(Bos Taurus)
Mammalia PTPN18 34 35
  • 84.57 (n)
mouse
(Mus musculus)
Mammalia Ptpn18 34 16 35
  • 80.9 (n)
rat
(Rattus norvegicus)
Mammalia Ptpn18 34
  • 78.98 (n)
dog
(Canis familiaris)
Mammalia PTPN18 34 35
  • 78.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTPN18 35
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 23 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 18 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia PTPN18 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730699 34
  • 61.87 (n)
zebrafish
(Danio rerio)
Actinopterygii ptpn18 34 35
  • 52.48 (n)
worm
(Caenorhabditis elegans)
Secernentea C17H12.3 36
  • 34 (a)
Y41D4A.5 35
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTP3 37
Species where no ortholog for PTPN18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN18 Gene

ENSEMBL:
Gene Tree for PTPN18 (if available)
TreeFam:
Gene Tree for PTPN18 (if available)

Paralogs for PTPN18 Gene

Paralogs for PTPN18 Gene

(5) SIMAP similar genes for PTPN18 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PTPN18: view

Variants for PTPN18 Gene

Sequence variations from dbSNP and Humsavar for PTPN18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000130156 -- 130,360,114(+) CTTCC(A/G)GGGTG intron-variant
rs1000251010 -- 130,362,851(+) GCCTC(A/G)CTCTG intron-variant
rs1000301124 -- 130,354,800(+) TAGGC(-/CA)CACAC upstream-variant-2KB
rs1000403384 -- 130,356,848(+) CTTAG(C/T)ACATA intron-variant
rs1000407346 -- 130,357,146(+) TGGTT(C/G)CACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPN18 Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv4073n100 CNV gain 25217958
dgv475n27 CNV gain 19166990
dgv7079n54 CNV loss 21841781
dgv7080n54 CNV gain 21841781
dgv7083n54 CNV loss 21841781
esv2751826 CNV gain 17911159
esv2759092 CNV gain+loss 17122850
esv2760631 CNV gain+loss 21179565
esv2763387 CNV loss 21179565
esv3584065 CNV loss 25503493
esv3592450 CNV loss 21293372
esv3592451 CNV gain 21293372
esv3893326 CNV gain 25118596
nsv1001073 CNV gain 25217958
nsv1005664 CNV loss 25217958
nsv1147463 OTHER inversion 26484159
nsv428403 CNV loss 18775914
nsv459274 CNV loss 19166990
nsv459341 CNV loss 19166990
nsv520559 CNV gain+loss 19592680
nsv583046 CNV loss 21841781
nsv583113 CNV gain 21841781
nsv583132 CNV gain 21841781
nsv583133 CNV loss 21841781
nsv7327 OTHER inversion 18451855
nsv998333 CNV gain+loss 25217958

Variation tolerance for PTPN18 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.14; 90.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPN18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPN18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN18 Gene

Disorders for PTPN18 Gene

Relevant External Links for PTPN18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPN18

No disorders were found for PTPN18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPN18 Gene

Publications for PTPN18 Gene

  1. Characterization of the PEST family protein tyrosine phosphatase BDP1. (PMID: 8950995) Kim Y.W. … Ullrich A. (Oncogene 1996) 2 3 4 22 64
  2. In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M. … Jurisica I. (Nat. Methods 2015) 3 64
  3. The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. (PMID: 24658140) Petschnigg J. … Stagljar I. (Nat. Methods 2014) 3 64
  4. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. (PMID: 25081058) Wang H.M. … Sun J.P. (Cell Res. 2014) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for PTPN18 Gene

Sources for PTPN18 Gene

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