Aliases for PTPN14 Gene
External Ids for PTPN14 Gene
Previous GeneCards Identifiers for PTPN14 Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]
GeneCards Summary for PTPN14 Gene
PTPN14 (Protein Tyrosine Phosphatase, Non-Receptor Type 14) is a Protein Coding gene. Diseases associated with PTPN14 include choanal atresia and lymphedema and choanal atresia. Among its related pathways are Adhesion and Angiogenesis (CST). GO annotations related to this gene include phosphatase activity and transcription cofactor activity. An important paralog of this gene is PTPN21.
UniProtKB/Swiss-Prot for PTPN14 Gene
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.