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Aliases for PTPN14 Gene

Aliases for PTPN14 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 14 2 3
  • PEZ 3 4 6
  • Protein-Tyrosine Phosphatase Pez 3 4
  • EC 3.1.3.48 4 63
  • Cytoskeletal-Associated Protein Tyrosine Phosphatase 3
  • Tyrosine-Protein Phosphatase Non-Receptor Type 14 3
  • EC 3.1.3 63
  • PTP36 3
  • PTPD2 4

External Ids for PTPN14 Gene

Previous GeneCards Identifiers for PTPN14 Gene

  • GC01M213183
  • GC01M210351
  • GC01M211133
  • GC01M211587
  • GC01M210919
  • GC01M212597
  • GC01M214530
  • GC01M185197
  • GC01M214523

Summaries for PTPN14 Gene

Entrez Gene Summary for PTPN14 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]

GeneCards Summary for PTPN14 Gene

PTPN14 (Protein Tyrosine Phosphatase, Non-Receptor Type 14) is a Protein Coding gene. Diseases associated with PTPN14 include choanal atresia and lymphedema and choanal atresia. Among its related pathways are PAK Pathway. GO annotations related to this gene include protein tyrosine phosphatase activity and receptor tyrosine kinase binding. An important paralog of this gene is PTPN6.

UniProtKB/Swiss-Prot for PTPN14 Gene

  • Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.

Gene Wiki entry for PTPN14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN14 Gene

Genomics for PTPN14 Gene

Regulatory Elements for PTPN14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPN14 Gene

Start:
214,348,267 bp from pter
End:
214,552,449 bp from pter
Size:
204,183 bases
Orientation:
Minus strand

Genomic View for PTPN14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN14 Gene

Proteins for PTPN14 Gene

  • Protein details for PTPN14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15678-PTN14_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 14
    Protein Accession:
    Q15678
    Secondary Accessions:
    • Q5VSI0

    Protein attributes for PTPN14 Gene

    Size:
    1187 amino acids
    Molecular mass:
    135261 Da
    Quaternary structure:
    • Interacts with FLT4; the interaction is enhanced by stimulation with VEGFC. Interacts (via PPxY motifs) with YAP1 (via WW domains); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional co-activator activity.

    Three dimensional structures from OCA and Proteopedia for PTPN14 Gene

neXtProt entry for PTPN14 Gene

Proteomics data for PTPN14 Gene at MOPED

Post-translational modifications for PTPN14 Gene

  • Ubiquitinated by the ECS (Elongin BC-CUL2/5-SOCS-box protein)/LRR1 E3 ligase complex and subsequently targeted to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPN14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PTPN14 Gene

Gene Families for PTPN14 Gene

HGNC:
  • PTPN :Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

Suggested Antigen Peptide Sequences for PTPN14 Gene

Graphical View of Domain Structure for InterPro Entry

Q15678

UniProtKB/Swiss-Prot:

PTN14_HUMAN :
  • Q15678
Domain:
  • Contains 1 FERM domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with PTPN14: view

Function for PTPN14 Gene

Molecular function for PTPN14 Gene

GENATLAS Biochemistry: protein tyrosine phosphatase,non receptor type 14
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
UniProtKB/Swiss-Prot Induction: Up-regulated at protein level by cell density. However, at the mRNA level remains the same regardless of the status of cell density.

Enzyme Numbers (IUBMB) for PTPN14 Gene

Gene Ontology (GO) - Molecular Function for PTPN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IMP 22525271
GO:0004725 protein tyrosine phosphatase activity IMP 22525271
GO:0005515 protein binding IPI 22525271
GO:0008138 protein tyrosine/serine/threonine phosphatase activity --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPN14: view
genes like me logo Genes that share phenotypes with PTPN14: view

Animal Model Products

CRISPR Products

miRNA for PTPN14 Gene

miRTarBase miRNAs that target PTPN14

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN14

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PTPN14 Gene

Localization for PTPN14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN14 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPN14 Gene COMPARTMENTS Subcellular localization image for PTPN14 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PTPN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10934049
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 10934049
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with PTPN14: view

Pathways for PTPN14 Gene

SuperPathways for PTPN14 Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPN14: view

Pathways by source for PTPN14 Gene

1 Qiagen pathway for PTPN14 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001946 lymphangiogenesis IMP 20826270
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006470 protein dephosphorylation TAS 7733990
GO:0008285 negative regulation of cell proliferation IMP 22948661
genes like me logo Genes that share ontologies with PTPN14: view

Compounds for PTPN14 Gene

(2) HMDB Compounds for PTPN14 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with PTPN14: view

Transcripts for PTPN14 Gene

Unigene Clusters for PTPN14 Gene

Protein tyrosine phosphatase, non-receptor type 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN14

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PTPN14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN14 Gene

No ASD Table

Relevant External Links for PTPN14 Gene

GeneLoc Exon Structure for
PTPN14
ECgene alternative splicing isoforms for
PTPN14

Expression for PTPN14 Gene

mRNA expression in normal human tissues for PTPN14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPN14 Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN14 Gene

SOURCE GeneReport for Unigene cluster for PTPN14 Gene Hs.193557

mRNA Expression by UniProt/SwissProt for PTPN14 Gene

Q15678-PTN14_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with PTPN14: view

In Situ Assay Products

Orthologs for PTPN14 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPN14 35
  • 99.41 (n)
  • 99.66 (a)
PTPN14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPN14 35
  • 89.95 (n)
  • 95.45 (a)
PTPN14 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPN14 35
  • 91.21 (n)
  • 95.7 (a)
PTPN14 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpn14 35
  • 85.94 (n)
  • 91.65 (a)
Ptpn14 16
Ptpn14 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPN14 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves PTPN14 35
  • 78.2 (n)
  • 85.23 (a)
PTPN14 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPN14 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn14 35
  • 69.02 (n)
  • 69.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pez 36
  • 27 (a)
OneToMany
Pez 37
  • 36 (a)
Species with no ortholog for PTPN14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTPN14 Gene

ENSEMBL:
Gene Tree for PTPN14 (if available)
TreeFam:
Gene Tree for PTPN14 (if available)

Paralogs for PTPN14 Gene

genes like me logo Genes that share paralogs with PTPN14: view

Variants for PTPN14 Gene

Sequence variations from dbSNP and Humsavar for PTPN14 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2780 -- 214,348,742(+) AATAG(A/G)TATCT utr-variant-3-prime, intron-variant
rs1060349 -- 214,356,316(-) AAGGC(A/G)TGGAA utr-variant-3-prime, intron-variant
rs1125452 -- 214,376,158(-) AATGC(A/G)GGGAG intron-variant
rs1135352 -- 214,369,476(-) CCAGA(A/G)GATGT reference, synonymous-codon, nc-transcript-variant
rs1472439 -- 214,352,260(-) TATTC(C/T)CTATT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPN14 Gene

Variant ID Type Subtype PubMed ID
nsv516687 CNV Loss 19592680
esv275028 CNV Loss 21479260
nsv468094 CNV Loss 19166990
esv2669067 CNV Deletion 23128226

Relevant External Links for PTPN14 Gene

HapMap Linkage Disequilibrium report
PTPN14
Human Gene Mutation Database (HGMD)
PTPN14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN14 Gene

Disorders for PTPN14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for PTPN14 Gene including...

Search for PTPN14 Gene in MalaCards »

(1) OMIM Diseases for PTPN14 Gene (603155)

UniProtKB/Swiss-Prot

PTN14_HUMAN
  • Choanal atresia and lymphedema (CHATLY) [MIM:613611]: A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. {ECO:0000269 PubMed:20826270}. Note=The disease is caused by mutations affecting the gene represented in this entry. A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family.
  • Note=Influence clinical severity of hereditary haemorragic telagiectasia (HHT).
  • Note=Frequently mutated in a variety of human cancers.

(1) University of Copenhagen DISEASES for PTPN14 Gene

Relevant External Links for PTPN14

Genetic Association Database (GAD)
PTPN14
Human Genome Epidemiology (HuGE) Navigator
PTPN14
genes like me logo Genes that share disorders with PTPN14: view

Publications for PTPN14 Gene

  1. The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin. (PMID: 12808048) Wadham C. … Khew-Goodall Y. (Mol. Biol. Cell 2003) 3 4 23
  2. Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains. (PMID: 7733990) Smith A.L. … Crompton M.R. (Biochem. Biophys. Res. Commun. 1995) 2 3 4
  3. PTP-Pez: a novel regulator of TGFbeta signaling. (PMID: 18677119) Wyatt L. … Khew-Goodall Y. (Cell Cycle 2008) 3 23
  4. Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells. (PMID: 10212280) Ogata M. … Hamaoka T. (J. Biol. Chem. 1999) 3 23
  5. Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation. (PMID: 10934049) Wadham C. … Khew-Goodall Y. (J. Cell Sci. 2000) 3 4

Products for PTPN14 Gene

  • antibodies-online peptides for PTPN14
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Sources for PTPN14 Gene

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