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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PTPN13 Gene

protein-coding GIFtS: 69
GCID: GC04P087515

protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95...

Explore 42 diseases affiliated with
PTPN13 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase)¹ ²		FAP-1² ³
PTP-BAS¹ ² ³		PNP1² ³
PTP1E¹ ² ³		HPTPE1¹
PTPL1¹ ² ³		EC 3.1.3.48³ ⁸
PTP-BL¹ ²		PTPLE²
Fas-Associated Protein-Tyrosine Phosphatase 1² ³		HPTP1E¹
Protein-Tyrosine Phosphatase 1E² ³		Tyrosine-Protein Phosphatase Non-Receptor Type 13²
Protein-Tyrosine Phosphatase PTPL1² ³		PTP-E1³

External Ids:	HGNC: 9646¹	Entrez Gene: 5783²	Ensembl: ENSG00000163629⁷	OMIM: 600267⁵	UniProtKB: Q12923³

Export aliases for PTPN13 gene to outside databases

Previous GC identifers: GC04P087673 GC04P087817 GC04P087974 GC04P087873 GC04P083259

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPN13:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling

molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and

oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus

and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and

cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through

the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to

interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four

alternatively spliced transcript variants, which encode distinct proteins, have been reported. (provided by RefSeq,

Oct 2008)

UniProtKB/Swiss-Prot: PTN13_HUMAN, Q12923

Function: Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic

signaling

Gene Wiki entry for PTPN13

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTPN13 gene promoter:
MEF-2A Pbx1a POU2F1 POU2F1a HFH-1 aMEF-2 E4BP4 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTPN13 promoter sequence

Search SABiosciences Chromatin IP Primers for PTPN13

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN13

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.3 Ensembl cytogenetic band: 4q21.3 HGNC cytogenetic band: 4q21.3

PTPN13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN13 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P087515: view genomic region (about GC identifiers)

Start:	87,515,468 bp from pter	End:	87,736,329 bp from pter
Size:	220,862 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PTN13_HUMAN, Q12923 (See protein sequence)

Recommended Name: Tyrosine-protein phosphatase non-receptor type 13

Size: 2485 amino acids; 276906 Da

Subunit: Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal

SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth

PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7 and ARHGAP29. Interacts (via

PDZ 3 domain) with PKN2 (via C-terminus)

Subcellular location: Cytoplasm, cytoskeleton (By similarity). Nucleus. Cell projection, lamellipodium.

Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover

Sequence caution: Sequence=AAH39610.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence;

6 PDB 3D structures from and Proteopedia for PTPN13:

1D5G (3D)

1Q7X (3D)

1WCH (3D)

3LNX (3D)

3LNY (3D)

3PDZ (3D)

Secondary accessions: B2RTR0 Q15159 Q15263 Q15264 Q15265 Q15674 Q16826 Q8IWH7 Q9NYN9 Q9UDA8

Alternative splicing: 4 isoforms: Q12923-1 Q12923-2 Q12923-3 Q12923-4 (May be due to a competing donor splice site)

Explore the universe of human proteins at neXtProt for PTPN13: NX_Q12923

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q12923

3 DME Specific Peptides for PTPN13 (Q12923)

HCSAGIGR

MVQTEDQY

KNRYKNILP

PTPN13 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_006255.1 NP_542414.1 NP_542415.1 NP_542416.1

ENSEMBL proteins:

ENSP00000408368 ENSP00000423531 ENSP00000322675 ENSP00000407249 ENSP00000422835

ENSP00000426626 ENSP00000394794

Human Recombinant Protein Products for PTPN13:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PTPN13

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11356191
GO:0005737	cytoplasm	IDA	14516276
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	IDA	14516276
GO:0030027	lamellipodium	IDA	11356191

PTPN13 for ontologies About GeneDecksing

PTPN13 Antibody Products:

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	ThermoFisher Antibodies for PTPN13

Assay Products for PTPN13:

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	GenScript Custom Assay Services for PTPN13
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PTPN13

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTPN13 for domains About GeneDecksing

5/14 InterPro domains/families (see all 14):

IPR019748 FERM_central

IPR003100 PAZ

IPR019750 Band_41_fam

IPR012153 Tyr_Pase_non-rcpt_typ-13

IPR000242 Tyr_Pase_rcpt/non-rcpt

Graphical View of Domain Structure for InterPro Entry Q12923

ProtoNet protein and cluster: Q12923

3 Blocks protein families:

IPB000242 Protein tyrosine phosphatase signature

IPB000299 Band 4.1 domain

IPB001478 PDZ/DHR/GLGF domain

UniProtKB/Swiss-Prot: PTN13_HUMAN, Q12923

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily

Similarity: Contains 1 FERM domain

Similarity: Contains 1 KIND domain

Similarity: Contains 5 PDZ (DHR) domains

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PTN13_HUMAN, Q12923

Function: Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic

signaling

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Genatlas biochemistry entry for PTPN13:

protein tyrosine phosphatase,non receptor type 13,with a membrane binding region homologous to that found in

cytoskeleton associated proteins,ezrin/moesin/radixin-like (ERM) family member,responding and participating in

reorganization of membrane-cytoplasmic interactions

Enzyme Number (IUBMB): EC 3.1.3.48¹ ²

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004725	protein tyrosine phosphatase activity	IDA	14516276
GO:0005515	protein binding	IPI	17657516

PTPN13 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for PTPN13:

Decreased TP53 protein express

G0/1 arrest

Increased G1 DNA content

Increased cell number in G1, s

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ptpn13):

cellular	growth/size	hematopoietic system	immune system	nervous system
vision/eye

PTPN13 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for PTPN13: Ptpn13^tm1Wjh Ptpn13^tm1Gru

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PTPN13

miRNA Products:		miRTarBase miRNAs that target PTPN13: hsa-mir-200c (MIRT005593), hsa-mir-194 (MIRT005894)

		OriGene 3'-UTR Clone (see all 4): PTPN13 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN13
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN13 (see all 16):
		hsa-miR-30c hsa-miR-3163 hsa-miR-520d-5p hsa-miR-429 hsa-miR-30d hsa-miR-1297 hsa-miR-200c hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: PTPN13 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PTPN13
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PTPN13
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		Sirion Biotech Customized stable knockdown cell line services for PTPN13 Sirion Biotech Customized inducible knockdown cell line services for PTPN13

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN13

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeleton remodeling_Reverse signaling by ephrin B

Cytoskeleton remodeling_Reverse signaling by ephrin B

1.00

Cytoskeleton remodeling Reverse signaling by ephrin B

0.94

Cell adhesion_Ephrins signaling

Cell adhesion Ephrins signaling

1.00

Cell adhesion_Ephrins signaling

1.00

Apoptosis Modulation and Signaling

Apoptosis Modulation and Signaling

1.00

Ephrin B reverse signaling

Ephrin B reverse signaling

1.00

PAK Pathway

Epithelial Adherens Junctions

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for PTPN13

	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cell adhesion Ephrins signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPN13

Epithelial Adherens Junctions

2 GeneGo (Thomson Reuters) Pathways for PTPN13

	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cell adhesion Ephrins signaling

3 BioSystems Pathways for PTPN13

	Apoptosis Modulation and Signaling
	Fc-epsilon receptor I signaling in mast cells
	Ephrin B reverse signaling

PTPN13 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTPN13

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/44 Interacting proteins for PTPN13 (Q12923^{1, 2, 3} ENSP00000394794⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FAS	P25445²^,³, ENSP00000347979⁴	MINT-8310831 MINT-8310795 MINT-8310858 MINT-8310845 MINT-8283218 MINT-8310809 MINT-8310820 MINT-8283266 I2D: score=5 STRING: ENSP00000347979
PLEKHA1	Q9HB21²^,³, ENSP00000357986⁴	MINT-65960 MINT-65969 MINT-65966 MINT-65968 MINT-65964 MINT-65965 I2D: score=2 STRING: ENSP00000357986
PKN2	Q16513²^,³, ENSP00000359552⁴	MINT-73308 MINT-73310 MINT-73309 MINT-73307 I2D: score=4 STRING: ENSP00000359552
TRIP6	Q15654²^,³, ENSP00000200457⁴	MINT-8312575 I2D: score=3 STRING: ENSP00000200457
APC	P25054²^,³, ENSP00000257430⁴	MINT-8311489 I2D: score=2 STRING: ENSP00000257430

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006470	protein dephosphorylation	TAS	7929060
GO:0035335	peptidyl-tyrosine dephosphorylation	TAS	7536343

PTPN13 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PTPN13 for compounds About GeneDecksing

EMD Millipore small molecules for PTPN13:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PTPN13

1 HMDB Compound for PTPN13 About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--

7 Novoseek chemical compound relationships for PTPN13 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	59.3	44	14516276 (3), 7929060 (2), 7536343 (2), 15242314 (2) (see all 24)
tripeptide	53.1	4	9030235 (1), 9079683 (1), 10537175 (1)
vanadate	36.4	1	16888780 (1)
phosphotyrosine	33.7	1	15226483 (1)
cycloheximide	27	1	10537175 (1)
carboplatin	10.9	6	15598589 (3), 15301708 (2)
leucine	0	2	7929060 (2)

Search CenterWatch for drugs/clinical trials and news about PTPN13 / PTN13

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PTPN13 gene (4 alternative transcripts):

NM_006264.2 NM_080683.2 NM_080684.2 NM_080685.2

Unigene Cluster for PTPN13:

Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)

Hs.436142 [show with all ESTs]

Unigene Representative Sequence: NM_080685

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000427191 ENST00000502971 ENST00000316707(uc003hqc.1) ENST00000411767

ENST00000507902 ENST00000511467 ENST00000508063 ENST00000511105 ENST00000436978(uc003hpy.3 uc003hpz.3 uc003hqa.3 uc003hqb.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): PTPN13 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN13
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN13 (see all 16):
		hsa-miR-30c hsa-miR-3163 hsa-miR-520d-5p hsa-miR-429 hsa-miR-30d hsa-miR-1297 hsa-miR-200c hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: PTPN13 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector (see all 4): PTPN13 (NM_080683)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN13

Additional cDNA sequence:

AB208904.1 AF233323.1 AK056151.1 BC039610.1 BC139915.1 BC140777.1 BC144520.1 BX647553.1

BX647689.1 D21209.1 D21210.1 D21211.1 L34583.1 U12129.1 U12130.1 U12131.1

X79676.1 X80289.1

15 DOTS entries:

DT.100686547 DT.75141731 DT.100814818 DT.423254 DT.97772240 DT.91985424 DT.100814816 DT.91862838

DT.95070783 DT.91764350 DT.100639996 DT.102829346 DT.91764344 DT.97779606 DT.87001261

24/152 AceView cDNA sequences (see all 152):

AI032518 BE252933 NM_080685 BX104723 AI985433 BU165395 NM_080683 BX119432

BQ574790 AA876182 H88888 AL699898 NM_006264 BU623204 BU627869 D21211

D21210 BM697912 AF233323 U12129 N71528 U12132 AW613869 AI373886

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN13 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25a	·
SP1:
SP2:																																									-
SP3:
SP4:																																					-		-		-

ExUns:	25b	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35	^	36	^	37	^	38	^	39	^	40	^	41	^	42	^	43	^	44	^	45	^	46	^	47	^	48a	·	48b
SP1:	-
SP2:	-
SP3:
SP4:	-

ECgene alternative splicing isoforms for PTPN13

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PTPN13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

PTPN13 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PTPN13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTPN13

SOURCE GeneReport for Unigene cluster: Hs.436142

UniProtKB/Swiss-Prot: PTN13_HUMAN, Q12923

Tissue specificity: Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung,

kidney and fetal brain

SABiosciences Expression via Pathway-Focused PCR Array including PTPN13:

Protein Phosphatases in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN13 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTPN13
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN13

In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN13

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for PTPN13 gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PTPN13¹	protein tyrosine phosphatase, non-receptor type 13 more	71.11(n) 70.75(a)		422591 XM_003641189.1 XP_003641237.1
lizard (Anolis carolinensis)	Reptilia	PTPN13⁶	--	68(a)	1 ↔ 1	5(44960677-45060900)
African clawed frog (Xenopus laevis)	Amphibia	BJ038340.1²	--	76.38(n)		BJ038340.1
zebrafish (Danio rerio)	Actinopterygii	mchr2²	G protein-coupled receptor mchr2	71.25(n)		AL920127.1
worm (Caenorhabditis elegans)	Secernentea	Y38C1AB.4³	--	30(a) (best of 2)		IV(695-14926) --

ENSEMBL Gene Tree for PTPN13 (if available)
TreeFam Gene Tree for PTPN13 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PTPN13 gene

PTPN1² PTPN3² PTPN20C² FRMPD2² PTPN4² PTPN9² PTPN14² PTPN21²

PTPN20B² PTPN2² PTPN20A²

18/19 SIMAP similar genes for PTPN13 using alignment to 4 protein entries: PTN13_HUMAN (see all proteins) (see all similar genes):

DKFZp686J1497 SYNJ2BP DLG4 PTPRR PTPRS DKFZp566K0524

PTPN20A PTPN20B DKFZp781C1038 PTPN1 PTPN4 TJP2

DKFZp761A0712 PTPN2 PTPN5 PTPN7 FRMPD2P1 FRMPD2P2

PTPN13 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77290511^1,2	C	--	87513509(+)	`TTAAT-/AAAAAA`	4	--	us2k¹		0	--	--	--	--
rs76114575^1,2	C	--	87513512(+)	`ATAAAA/CAAAAA`	4	--	us2k¹		0	--	--	--	--
rs78369715^1,2	C	--	87513514(+)	`AAAAAA/GAAAAA`	4	--	us2k¹		0	--	--	--	--
rs181413807^1,2		--	87513523(+)	`AACACA/GAAGAA`	4	--	us2k¹		0	--	--	--	--
rs150099953^1,2		--	87513548(+)	`AAAAAA/GCTAAC`	4	--	us2k¹		0	--	--	--	--
rs147768750^1,2		--	87513569(+)	`TTTGTC/GTACTT`	4	--	us2k¹		0	--	--	--	--
rs72665771^1,2	C,F	--	87513579(+)	`TTTGCG/AGAAAT`	4	--	us2k¹		6		NA CSA WA EA	364
rs141080233^1,2		--	87513591(+)	`TACAAC/TACTAT`	4	--	us2k¹		0	--	--	--	--
rs115961574^1,2	C,F	--	87513593(+)	`CAACAC/TTATAC`	4	--	us2k¹		1		NA	120
rs186602677^1,2		--	87513632(+)	`CACAAA/GCTATT`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PTPN13 (87515468 - 87736329 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PTPN13
2 CNVs: 2534 98785
Human Gene Mutation Database (HGMD): PTPN13

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PTPN13 for disorders           About GeneDecksing

OMIM gene information: 600267    OMIM disorders: --

20/42 diseases for PTPN13 (see all 42):    About MalaCards

human t-cell leukemia virus type 1 tropical spastic paraparesis cavernous malformation spastic paraparesis

adenomatous polyposis coli cerebral cavernous malformations squamous cell carcinoma of the head and neck systemic lupus erythematosus

squamous cell carcinoma lupus erythematosus spasticity fanconi's anemia

kaposi's sarcoma polyposis colon carcinoma hepatocellular carcinoma

t-cell leukemia rheumatoid arthritis polyneuropathy colon cancer

1 disease from the University of Copenhagen DISEASES database for PTPN13:

Polyneuropathy

10/15 Novoseek disease relationships for PTPN13 gene (see all 15) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	49.6	5	20039457 (2), 11696979 (1), 15494722 (1), 10660140 (1)
colon cancer	41.2	15	16706817 (4), 17585452 (3), 15494722 (2), 9030235 (1) (see all 6)
tumors	32.7	31	11290551 (5), 19004008 (2), 8824809 (2), 9261095 (1) (see all 17)
autoimmune thyroid disease	32.3	1	10524501 (1)
allelic loss	27.9	3	12436199 (1), 16489062 (1)
leukemia t-cell	24.3	2	10660109 (1), 9491917 (1)
ovarian cancer	23.5	16	11290551 (5), 15301708 (3), 10828836 (1), 8824809 (1)
necrosis	21.3	3	9261095 (1), 9375749 (1), 10497846 (1)
primary tumor	16.1	1	15782144 (1)
pancreatic cancer	1.83	4	11683408 (2), 11172597 (1)

Genetic Association Database (GAD): PTPN13
Human Genome Epidemiology (HuGE) Navigator: PTPN13 (7 documents)

Export disorders for PTPN13 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PTPN13 gene, integrated from 9 sources (see all 150):
(articles sorted by number of sources associating them with PTPN13)

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Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats. (PubMed id 8287977)^{1, 2, 3, 9} Maekawa K.... Harada S. (1994)
Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket. (PubMed id 15611135)^{1, 2, 9} Villa F.... van Aalten D.M. (2005)
Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1. (PubMed id 14516276)^{1, 2, 9} Kimber W.A.... Alessi D.R. (2003)
Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. (PubMed id 10544233)^{1, 2, 9} Irie S.... Sato T.A. (1999)
Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins. (PubMed id 7929060)^{1, 2, 9} Saras J.... Gonez L.J. (1994)
FAP-1: a protein tyrosine phosphatase that associates with Fas. (PubMed id 7536343)^{1, 2, 9} Sato T.... Reed J.C. (1995)
Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene. (PubMed id 12436199)^{1, 2, 9} Yoshida S....Emi M. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions. (PubMed id 12095257)^{1, 2} Kozlov G.... Ekiel I. (2002)
The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif. (PubMed id 11356191)^{1, 2} Gross C....Erdmann K.S. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5783	HGNC: 9646	AceView: PTPN13	Ensembl:ENSG00000163629	euGenes: HUgn5783
ECgene: PTPN13	H-InvDB: PTPN13

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PTPN13	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PTPN13	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PTPN13 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PTPN13 gene:
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GeneCards and IP:
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