Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PTPN13 Gene

protein-coding   GIFtS: 69
GCID: GC04P087515

Protein Tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95...

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95
(Fas)-Associated Phosphatase)1 2
     PTPL12 3
Fas-Associated Protein-Tyrosine Phosphatase 12 3     hPTPE12 3
Protein-Tyrosine Phosphatase 1E2 3     EC 3.1.3.483 8
Protein-Tyrosine Phosphatase PTPL12 3     PTP-BL2
FAP-12 3     PTPLE2
PNP12 3     hPTP1E2
PTP-BAS2 3     Tyrosine-Protein Phosphatase Non-Receptor Type 132
PTP1E2 3     PTP-E13

External Ids:    HGNC: 96461   Entrez Gene: 57832   Ensembl: ENSG000001636297   OMIM: 6002675   UniProtKB: Q129233   

Export aliases for PTPN13 gene to outside databases

Previous GC identifers: GC04P087673 GC04P087817 GC04P087974 GC04P087873 GC04P083259


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PTPN13 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling
molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle,
and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its
C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to
plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor
and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This
PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho
signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been
reported. (provided by RefSeq, Oct 2008)

GeneCards Summary for PTPN13 Gene:
PTPN13 (protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)) is a protein-coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is FRMD1.

UniProtKB/Swiss-Prot: PTN13_HUMAN, Q12923
Function: Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic
signaling

Gene Wiki entry for PTPN13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPN13 gene promoter:
         MEF-2A   Pbx1a   POU2F1   POU2F1a   HFH-1   aMEF-2   E4BP4   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN13 promoter sequence
   Search Chromatin IP Primers for PTPN13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.3   Ensembl cytogenetic band:  4q21.3   HGNC cytogenetic band: 4q21.3

PTPN13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN13 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P087515:  view genomic region     (about GC identifiers)

Start:
87,515,468 bp from pter      End:
87,736,329 bp from pter
Size:
220,862 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PTN13_HUMAN, Q12923 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 13  
Size: 2485 amino acids; 276906 Da
Subunit: Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the
C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its
second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7 and
ARHGAP29. Interacts (via PDZ 3 domain) with PKN2 (via C-terminus)
Sequence caution: Sequence=AAH39610.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Selected PDB 3D structures from and Proteopedia for PTPN13 (see all 8):
1D5G (3D)        1Q7X (3D)        1WCH (3D)        2M0Z (3D)        2M10 (3D)        3LNX (3D)    
Secondary accessions: B2RTR0 Q15159 Q15263 Q15264 Q15265 Q15674 Q16826 Q8IWH7 Q9NYN9 Q9UDA8
Alternative splicing: 4 isoforms:  Q12923-1   Q12923-2   Q12923-3   Q12923-4   (May be due to a competing donor splice site)

Explore the universe of human proteins at neXtProt for PTPN13: NX_Q12923

Explore proteomics data for PTPN13 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for PTPN13 (Q12923)
     HCSAGIGR  MVQTEDQY  KNRYKNILP 


    See PTPN13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_006255.1  NP_542414.1  NP_542415.1  NP_542416.1  

    ENSEMBL proteins: 
     ENSP00000408368   ENSP00000423531   ENSP00000322675   ENSP00000407249   ENSP00000422835  
     ENSP00000426626   ENSP00000394794  

    PTPN13 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PTPN13
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PTPN13
    GenScript Custom Purified and Recombinant Proteins Services for PTPN13
    Novus Biologicals PTPN13 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTPN13

     
    Search eBioscience for Proteins for PTPN13 

     
    antibodies-online proteins for PTPN13 (2 products) 

     
    Search antibodies-online for peptides for PTPN13

    PTPN13 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PTPN13 (PTPN13/PTPL1)
    OriGene Antibodies for PTPN13
    OriGene Custom Antibody Services for PTPN13
    Novus Biologicals PTPN13 Antibodies
    Abcam antibodies for PTPN13
    Cloud-Clone Corp. Antibodies for PTPN13
    ThermoFisher Antibodies for PTPN13
    antibodies-online antibodies for PTPN13 (39 products) 

    PTPN13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTPN13
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTPN13
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTPN13
    Cloud-Clone Corp. CLIAs for PTPN13
    Search eBioscience for ELISAs for PTPN13 
    antibodies-online kits for PTPN13 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    Selected InterPro protein domains (see all 13):
     IPR019748 FERM_central
     IPR019750 Band_41_fam
     IPR012153 Tyr_Pase_non-rcpt_typ-13
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q12923

    ProtoNet protein and cluster: Q12923

    3 Blocks protein domains:
    IPB000242 Protein tyrosine phosphatase signature
    IPB000299 Band 4.1 domain
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: PTN13_HUMAN, Q12923
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 KIND domain
    Similarity: Contains 5 PDZ (DHR) domains
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPN13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN13_HUMAN, Q12923
    Function: Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic
    signaling
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN13:
    protein tyrosine phosphatase,non receptor type 13,with a membrane binding region homologous to that found in
    cytoskeleton associated proteins,ezrin/moesin/radixin-like (ERM) family member,responding and participating in
    reorganization of membrane-cytoplasmic interactions

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IDA14516276
    GO:0005515protein binding IPI10918185
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with PTPN13           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PTPN13:
     Decreased TP53 protein express  G0/1 arrest  Increased G1 DNA content  Increased cell number in G1, s 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptpn13):
     cellular  growth/size/body  hematopoietic system  immune system  nervous system 
     vision/eye 

    Find genes that share phenotypes with PTPN13           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTPN13: Ptpn13tm1Wjh Ptpn13tm1Gru

       genOway: Develop your customized and physiologically relevant rodent model for PTPN13

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTPN13:
    hsa-mir-186-5p (MIRT045058), hsa-mir-200c-3p (MIRT005593), hsa-mir-331-3p (MIRT043492), hsa-mir-92a-3p (MIRT049422), hsa-mir-194-5p (MIRT005894)

    Block miRNA regulation of human, mouse, rat PTPN13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPN13 (see all 16):
    hsa-miR-30c hsa-miR-3163 hsa-miR-520d-5p hsa-miR-429 hsa-miR-30d hsa-miR-1297 hsa-miR-200c hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidPTPN13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PTPN13
    Predesigned siRNA for gene silencing in human, mouse, rat PTPN13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTPN13

    Clone
    Products:
         
    OriGene clones in human, mouse for PTPN13 (see all 17)
    OriGene ORF clones in mouse, rat for PTPN13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PTPN13 (NM_080683)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN13
    Addgene plasmids for PTPN13 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PTPN13
    Browse ESI BIO Cell Lines and PureStem Progenitors for PTPN13 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PTN13_HUMAN, Q12923: Cytoplasm, cytoskeleton (By similarity). Nucleus. Cell projection, lamellipodium.
    Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol3
    cytoskeleton2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11356191
    GO:0005737cytoplasm IDA14516276
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IDA14516276
    GO:0030027lamellipodium IDA11356191

    Find genes that share ontologies with PTPN13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PTPN13 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis (WikiPathways)
    Apoptosis Modulation and Signaling0.38
    2PAK Pathway
    Epithelial Adherens Junctions0.36
    3Immune response Fc epsilon RI pathway
    Fc-epsilon receptor I signaling in mast cells0.34
    4EphB-EphrinB Signaling
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    5EPHB forward signaling
    Cell adhesion Ephrins signaling0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPN13
        Epithelial Adherens Junctions

    2 GeneGo (Thomson Reuters) Pathways for PTPN13
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    3 BioSystems Pathways for PTPN13
        Apoptosis Modulation and Signaling
    Ephrin B reverse signaling
    Fc-epsilon receptor I signaling in mast cells


        Pathway & Disease-focused RT2 Profiler PCR Array including PTPN13: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPN13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTPN13 (Q129231, 2, 3 ENSP000003947944) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FASP254451, 2, 3, ENSP000003479794EBI-355227,EBI-494743 MINT-8310831 MINT-8310795 MINT-8310858 MINT-8310845 MINT-8283218 MINT-8310809 MINT-8310820 MINT-8283266 I2D: score=5 STRING: ENSP00000347979
    PLEKHA1Q9HB212, 3, ENSP000003579864MINT-65960 MINT-65969 MINT-65966 MINT-65968 MINT-65964 MINT-65965 I2D: score=2 STRING: ENSP00000357986
    PKN2Q165132, 3, ENSP000003595524MINT-73308 MINT-73310 MINT-73309 MINT-73307 I2D: score=4 STRING: ENSP00000359552
    TRIP6Q156542, 3, ENSP000002004574MINT-8312575 I2D: score=3 STRING: ENSP00000200457
    APCP250542, 3, ENSP000002574304MINT-8311489 I2D: score=2 STRING: ENSP00000257430
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS7929060
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS7536343

    Find genes that share ontologies with PTPN13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTPN13 (PTN13)

    1 HMDB Compound for PTPN13    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    7 Novoseek inferred chemical compound relationships for PTPN13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 59.3 44 14516276 (3), 7929060 (2), 7536343 (2), 15242314 (2) (see all 24)
    tripeptide 53.1 4 9030235 (1), 9079683 (1), 10537175 (1)
    vanadate 36.4 1 16888780 (1)
    phosphotyrosine 33.7 1 15226483 (1)
    cycloheximide 27 1 10537175 (1)
    carboplatin 10.9 6 15598589 (3), 15301708 (2)
    leucine 0 2 7929060 (2)



    Find genes that share compounds with PTPN13           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PTPN13 gene (4 alternative transcripts): 
    NM_006264.2  NM_080683.2  NM_080684.2  NM_080685.2  

    Unigene Cluster for PTPN13:

    Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
    Hs.436142  [show with all ESTs]
    Unigene Representative Sequence: NM_080685
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427191 ENST00000502971 ENST00000316707(uc003hqc.1) ENST00000411767
    ENST00000507902 ENST00000511467 ENST00000508063 ENST00000511105 ENST00000436978(uc003hpy.3 uc003hpz.3 uc003hqa.3 uc003hqb.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PTPN13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPN13 (see all 16):
    hsa-miR-30c hsa-miR-3163 hsa-miR-520d-5p hsa-miR-429 hsa-miR-30d hsa-miR-1297 hsa-miR-200c hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidPTPN13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PTPN13
    Predesigned siRNA for gene silencing in human, mouse, rat PTPN13
    Clone
    Products:
         
    OriGene clones in human, mouse for PTPN13 (see all 17)
    OriGene ORF clones in mouse, rat for PTPN13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PTPN13 (NM_080683)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN13
    Addgene plasmids for PTPN13 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PTPN13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPN13
      QuantiTect SYBR Green Assays in human, mouse, rat PTPN13
      QuantiFast Probe-based Assays in human, mouse, rat PTPN13

    Additional mRNA sequence: 

    AB208904.1 AF233323.1 AK056151.1 BC039610.1 BC139915.1 BC140777.1 BC144520.1 BX647553.1 
    BX647689.1 D21209.1 D21210.1 D21211.1 L34583.1 U12129.1 U12130.1 U12131.1 
    X79676.1 X80289.1 

    16 DOTS entries:

    DT.100686547  DT.100814818  DT.75141731  DT.423254  DT.91985424  DT.97772240  DT.100814816  DT.91862838 
    DT.95070783  DT.91764350  DT.100639996  DT.101977633  DT.102829346  DT.91764344  DT.97779606  DT.87001261 

    Selected AceView cDNA sequences (see all 152):

    BX119432 BM698667 H88887 AI142870 BX104723 AF233323 AL699898 AA876182 
    BQ574790 NM_080684 AI369996 D21210 U12132 AI985433 BU607497 AI032518 
    AW631059 BU159686 AI620524 CA423505 N22160 D21209 BX646070 CA428333 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN13    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                          -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -     -     -                                 

    ExUns: 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48a · 48b
    SP1:  -                                                                                                                                                   
    SP2:  -                                                                                                                                                   
    SP3:                                                                                                                                                      
    SP4:  -                                                                                                                                                   


    ECgene alternative splicing isoforms for PTPN13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PTPN13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTPN13 Expression
    About this image


    PTPN13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PTPN13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPN13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436142

    UniProtKB/Swiss-Prot: PTN13_HUMAN, Q12923
    Tissue specificity: Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in
    lung, kidney and fetal brain

        Pathway & Disease-focused RT2 Profiler PCR Array including PTPN13: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PTPN13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPN13
    QuantiTect SYBR Green Assays in human, mouse, rat PTPN13
    QuantiFast Probe-based Assays in human, mouse, rat PTPN13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PTPN13 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn131 , 5 protein tyrosine phosphatase, non-receptor type 131, 5 81.39(n)1
    81.83(a)1
      5 (50.43 cM)5
    192491  NM_011204.21  NP_035334.21 
     1034251925 
    chicken
    (Gallus gallus)
    Aves PTPN131 protein tyrosine phosphatase, non-receptor type 13 more 71.08(n)
    70.71(a)
      422591  XM_003641189.2  XP_003641237.2 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN136
    protein tyrosine phosphatase, non-receptor type 13...
    68(a)
    1 ↔ 1
    5(44927806-45060912)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ038340.12   -- 76.38(n)    BJ038340.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mchr22 G protein-coupled receptor mchr2 71.25(n)    AL920127.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y38C1AB.43   -- 30(a)
    (best of 2)
      IV(695-14926)   --


    ENSEMBL Gene Tree for PTPN13 (if available)
    TreeFam Gene Tree for PTPN13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PTPN13 gene
    FRMD12  FRMPD22  FRMD62  
    Selected SIMAP similar genes for PTPN13 using alignment to 4 protein entries:     PTN13_HUMAN (see all proteins) (see all similar genes):
    DKFZp686J1497    SYNJ2BP    DLG4    PTPRR    PTPRS    DKFZp566K0524
    PTPN20A    PTPN20B    DKFZp781C1038    PTPN1    PTPN4    TJP2
    DKFZp761A0712    PTN2    PTPN5    PTPN7    FRMPD2P1    FRMPD2P2

    Find genes that share paralogs with PTPN13           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PTPN13 (see all 3962)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs772905111,2
    C--87513509(+) TTAAT-/AAAAAA 4 -- us2k10--------
    rs761145751,2
    C--87513512(+) ATAAAA/CAAAAA 4 -- us2k10--------
    rs783697151,2
    C--87513514(+) AAAAAA/GAAAAA 4 -- us2k10--------
    rs1814138071,2
    C--87513523(+) AACACA/GAAGAA 4 -- us2k10--------
    rs1500999531,2
    --87513548(+) AAAAAA/GCTAAC 4 -- us2k10--------
    rs1477687501,2
    --87513569(+) TTTGTC/GTACTT 4 -- us2k10--------
    rs726657711,2
    C,F--87513579(+) TTTGCG/AGAAAT 4 -- us2k16Minor allele frequency- A:0.22NA CSA WA EA 364
    rs1410802331,2
    --87513591(+) TACAAC/TACTAT 4 -- us2k10--------
    rs1159615741,2
    C,F--87513593(+) CAACAC/TTATAC 4 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1866026771,2
    --87513632(+) CACAAA/GCTATT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTPN13 (87515468 - 87736329 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTPN13 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv999120CNV Deletion20482838
    esv2659040CNV Deletion23128226
    esv2653947CNV Deletion19546169
    nsv507180CNV Insertion20534489
    nsv879522CNV Loss21882294
    nsv528327CNV Loss19592680
    dgv5640n71CNV Loss21882294
    nsv508296CNV Loss20534489
    nsv822635CNV Loss20364138
    nsv830001CNV Loss17160897

    Human Gene Mutation Database (HGMD): PTPN13
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTPN13
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPN13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600267    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PTPN13:
    Polyneuropathy

    Find genes that share disorders with PTPN13           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PTPN13 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 49.6 5 20039457 (2), 11696979 (1), 15494722 (1), 10660140 (1)
    colon cancer 41.2 15 16706817 (4), 17585452 (3), 15494722 (2), 9030235 (1) (see all 6)
    tumors 32.7 31 11290551 (5), 19004008 (2), 8824809 (2), 9261095 (1) (see all 17)
    autoimmune thyroid disease 32.3 1 10524501 (1)
    allelic loss 27.9 3 12436199 (1), 16489062 (1)
    leukemia t-cell 24.3 2 10660109 (1), 9491917 (1)
    ovarian cancer 23.5 16 11290551 (5), 15301708 (3), 10828836 (1), 8824809 (1)
    necrosis 21.3 3 9261095 (1), 9375749 (1), 10497846 (1)
    primary tumor 16.1 1 15782144 (1)
    pancreatic cancer 1.83 4 11683408 (2), 11172597 (1)

    Genetic Association Database (GAD): PTPN13
    Human Genome Epidemiology (HuGE) Navigator: PTPN13 (7 documents)

    Export disorders for PTPN13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PTPN13 gene, integrated from 10 sources (see all 161):
    (articles sorted by number of sources associating them with PTPN13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats. (PubMed id 8287977)1, 2, 3, 9 Maekawa K.... Harada S. (FEBS Lett. 1994)
    2. Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket. (PubMed id 15611135)1, 2, 9 Villa F.... van Aalten D.M. (J. Biol. Chem. 2005)
    3. Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1. (PubMed id 14516276)1, 2, 9 Kimber W.A.... Alessi D.R. (Biochem. J. 2003)
    4. Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. (PubMed id 10544233)1, 2, 9 Irie S.... Sato T.A. (FEBS Lett. 1999)
    5. Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins. (PubMed id 7929060)1, 2, 9 Saras J.... Gonez L.J. (J. Biol. Chem. 1994)
    6. FAP-1: a protein tyrosine phosphatase that associates with Fas. (PubMed id 7536343)1, 2, 9 Sato T.... Reed J.C. (Science 1995)
    7. Genetic polymorphisms in the PTPN13 gene and risk of squamous cell carcinoma of head and neck. (PubMed id 19892796)1, 4, 9 Niu J....Wei Q. (Carcinogenesis 2009)
    8. Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene. (PubMed id 12436199)1, 2, 9 Yoshida S.... Emi M. (J. Hum. Genet. 2002)
    9. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5783 HGNC: 9646 AceView: PTPN13 Ensembl:ENSG00000163629 euGenes: HUgn5783
    ECgene: PTPN13 H-InvDB: PTPN13

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PTPN13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN13 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PTPN13 gene:
    Search GeneIP for patents involving PTPN13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for PTPN13 (PTPN13/PTPL1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PTPN13   OriGene RNAi products in human, mouse, rat for PTPN13  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PTPN13  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PTPN13  
     OriGene qSTAR qPCR primer pairs in human, mouse for PTPN13   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PTPN13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PTPN13   OriGene Custom Protein Services for PTPN13  

     
     
     Block miRNA regulation of human, mouse, rat PTPN13 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PTPN13
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN13 Predesigned siRNA for gene silencing in human, mouse, rat PTPN13
     QuantiFast Probe-based Assays in human, mouse, rat PTPN13 QuantiTect SYBR Green Assays in human, mouse, rat PTPN13
     PCR Arrays including human, mouse, rat PTPN13 Search Chromatin IP Primers for PTPN13
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPN13  GeneGlobe Interaction Network for PTPN13
     Regulatory tfbs in PTPN13 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PTPN13 GenScript cDNA clones with any tag delivered in your preferred vector for PTPN13
     GenScript Custom Assay Services for PTPN13 GenScript Custom overexpressing Cell Line Services for PTPN13
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PTPN13 (PTN13)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PTPN13 antibodies
     PTPN13 proteins
     Antibodies for PTPN13
     See all of Abcam's Antibodies, Kits and Proteins for PTPN13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PTPN13
     Antibodies for PTPN13
     ELISAs for PTPN13
     CLIAs for PTPN13



     Browse ESI BIO Cell Lines and PureStem Progenitors for PTPN13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN13
     SwitchGear 3'UTR luciferase reporter plasmids for PTPN13
     SwitchGear Promoter luciferase reporter plasmids for PTPN13
     ThermoFisher Antibodies for PTPN13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN13
     Browse compounds at ApexBio
     Addgene plasmids for PTPN13
      Search eBioscience for proteins for PTPN13
      Search eBioscience for elisas for PTPN13
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PTPN13
     antibodies-online antibodies for PTPN13 (39 products)
     antibodies-online kits for PTPN13 (5 products)
      Search antibodies-online for peptides for PTPN13
     antibodies-online proteins for PTPN13 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PTPN13 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4