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Aliases for PTPN13 Gene

Aliases for PTPN13 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) 2 3
  • Fas-Associated Protein-Tyrosine Phosphatase 1 3 4
  • Protein-Tyrosine Phosphatase PTPL1 3 4
  • Protein-Tyrosine Phosphatase 1E 3 4
  • EC 3.1.3.48 4 63
  • PTP-BAS 3 4
  • HPTPE1 3 4
  • FAP-1 3 4
  • PTP1E 3 4
  • PTPL1 3 4
  • PNP1 3 4
  • Tyrosine-Protein Phosphatase Non-Receptor Type 13 3
  • PTP-BL 3
  • HPTP1E 3
  • PTP-E1 4
  • PTPLE 3

External Ids for PTPN13 Gene

Previous GeneCards Identifiers for PTPN13 Gene

  • GC04P087673
  • GC04P087817
  • GC04P087974
  • GC04P087873
  • GC04P087515
  • GC04P083259

Summaries for PTPN13 Gene

Entrez Gene Summary for PTPN13 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

GeneCards Summary for PTPN13 Gene

PTPN13 (Protein Tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase)) is a Protein Coding gene. Among its related pathways are PAK Pathway and Ephrin B reverse signaling. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is FRMD1.

UniProtKB/Swiss-Prot for PTPN13 Gene

  • Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).

Gene Wiki entry for PTPN13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN13 Gene

Genomics for PTPN13 Gene

Regulatory Elements for PTPN13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPN13 Gene

Start:
86,594,315 bp from pter
End:
86,815,179 bp from pter
Size:
220,865 bases
Orientation:
Plus strand

Genomic View for PTPN13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN13 Gene

Proteins for PTPN13 Gene

  • Protein details for PTPN13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12923-PTN13_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 13
    Protein Accession:
    Q12923
    Secondary Accessions:
    • B2RTR0
    • Q15159
    • Q15263
    • Q15264
    • Q15265
    • Q15674
    • Q16826
    • Q8IWH7
    • Q9NYN9
    • Q9UDA8

    Protein attributes for PTPN13 Gene

    Size:
    2485 amino acids
    Molecular mass:
    276906 Da
    Quaternary structure:
    • Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7. Interacts with ARHGAP29. Interacts (via PDZ 3 domain) with PKN2 (via C-terminus). Interacts with PIK3R2; dephosphorylates PIK3R2 (PubMed:23604317). Interacts with FBXL2 (PubMed:23604317). Interacts with SDCCAG3 (PubMed:23108400).
    SequenceCaution:
    • Sequence=AAH39610.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPN13 Gene

    Alternative splice isoforms for PTPN13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPN13 Gene

Proteomics data for PTPN13 Gene at MOPED

Selected DME Specific Peptides for PTPN13 Gene

Post-translational modifications for PTPN13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for PTPN13 (PTPN13/PTPL1)

Domains for PTPN13 Gene

Gene Families for PTPN13 Gene

HGNC:
  • PTPN :Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

Suggested Antigen Peptide Sequences for PTPN13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12923

UniProtKB/Swiss-Prot:

PTN13_HUMAN :
  • Q12923
Domain:
  • Contains 1 FERM domain.
  • Contains 1 KIND domain.
  • Contains 5 PDZ (DHR) domains.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with PTPN13: view

Function for PTPN13 Gene

Molecular function for PTPN13 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,non receptor type 13,with a membrane binding region homologous to that found in cytoskeleton associated proteins,ezrin/moesin/radixin-like (ERM) family member,responding and participating in reorganization of membrane-cytoplasmic interactions
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot Function:
Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).

Enzyme Numbers (IUBMB) for PTPN13 Gene

Gene Ontology (GO) - Molecular Function for PTPN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IMP 23604317
GO:0005515 protein binding IPI 10918185
GO:0016791 phosphatase activity --
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IPI 23604317
genes like me logo Genes that share ontologies with PTPN13: view
genes like me logo Genes that share phenotypes with PTPN13: view

Animal Models for PTPN13 Gene

MGI Knock Outs for PTPN13:

Animal Model Products

CRISPR Products

No data available for Transcription Factor Targeting and HOMER Transcription for PTPN13 Gene

Localization for PTPN13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN13 Gene

Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium. Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPN13 Gene COMPARTMENTS Subcellular localization image for PTPN13 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for PTPN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11356191
GO:0005737 cytoplasm IDA 14516276
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA 14516276
GO:0030027 lamellipodium IDA 11356191
genes like me logo Genes that share ontologies with PTPN13: view

Pathways for PTPN13 Gene

genes like me logo Genes that share pathways with PTPN13: view

Pathways by source for PTPN13 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IDA 17657516
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling IDA 23604317
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation IMP 23604317
genes like me logo Genes that share ontologies with PTPN13: view

Compounds for PTPN13 Gene

(1) HMDB Compounds for PTPN13 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2

(7) Novoseek inferred chemical compound relationships for PTPN13 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 59.3 32
tripeptide 53.1 3
vanadate 36.4 1
phosphotyrosine 33.7 1
cycloheximide 27 1
genes like me logo Genes that share compounds with PTPN13: view

Transcripts for PTPN13 Gene

Unigene Clusters for PTPN13 Gene

Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPN13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1:
SP2: -
SP3:
SP4: - - -

ExUns: 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48a · 48b
SP1: -
SP2: -
SP3:
SP4: -

Relevant External Links for PTPN13 Gene

GeneLoc Exon Structure for
PTPN13
ECgene alternative splicing isoforms for
PTPN13

Expression for PTPN13 Gene

mRNA expression in normal human tissues for PTPN13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PTPN13 Gene

This gene is overexpressed in Retina (16.4), Bone marrow stromal cell (11.2), Cervix (9.4), Heart (9.0), and Urine (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN13 Gene

SOURCE GeneReport for Unigene cluster for PTPN13 Gene Hs.436142

mRNA Expression by UniProt/SwissProt for PTPN13 Gene

Q12923-PTN13_HUMAN
Tissue specificity: Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain
genes like me logo Genes that share expressions with PTPN13: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for PTPN13 Gene

Orthologs for PTPN13 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPN13 35
  • 89.57 (n)
  • 88.34 (a)
PTPN13 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPN13 35
  • 91.38 (n)
  • 89.8 (a)
PTPN13 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpn13 35
  • 81.39 (n)
  • 81.83 (a)
Ptpn13 16
Ptpn13 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPN13 35
  • 99.45 (n)
  • 99.4 (a)
PTPN13 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpn13 35
  • 80.09 (n)
  • 80.01 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPN13 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPN13 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPN13 35
  • 71.08 (n)
  • 70.71 (a)
PTPN13 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPN13 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn13 35
  • 63.78 (n)
  • 60.05 (a)
zebrafish
(Danio rerio)
Actinopterygii mchr2 35
ptpn13 35
  • 58.31 (n)
  • 56.78 (a)
ptpn13 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F55F8.7 37
  • 30 (a)
Y38C1AB.4 37
  • 30 (a)
frm-5.1 36
  • 19 (a)
ManyToMany
frm-5.2 36
  • 21 (a)
ManyToMany
Species with no ortholog for PTPN13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN13 Gene

ENSEMBL:
Gene Tree for PTPN13 (if available)
TreeFam:
Gene Tree for PTPN13 (if available)

Paralogs for PTPN13 Gene

Paralogs for PTPN13 Gene

genes like me logo Genes that share paralogs with PTPN13: view

Variants for PTPN13 Gene

Sequence variations from dbSNP and Humsavar for PTPN13 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs710832 -- 86,762,878(-) CCAGA(C/T)GGCCC reference, synonymous-codon
rs969734 -- 86,744,231(-) GGCAT(A/G)AAGGC intron-variant
rs980637 -- 86,684,182(+) CTACG(C/T)CATCA intron-variant
rs980638 -- 86,684,337(+) GCTCA(C/T)GAAAA intron-variant
rs989902 - 86,785,353(-) GGAGT(A/C)TCCTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for PTPN13 Gene

Variant ID Type Subtype PubMed ID
dgv1649e1 CNV Complex 17122850
nsv879522 CNV Loss 21882294
nsv822635 CNV Loss 20364138
dgv5640n71 CNV Loss 21882294
nsv830001 CNV Loss 17160897
nsv508296 CNV Loss 20534489
esv999120 CNV Deletion 20482838
esv2659040 CNV Deletion 23128226
nsv528327 CNV Loss 19592680
nsv507180 CNV Insertion 20534489
esv2653947 CNV Deletion 19546169

Relevant External Links for PTPN13 Gene

HapMap Linkage Disequilibrium report
PTPN13
Human Gene Mutation Database (HGMD)
PTPN13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN13 Gene

Disorders for PTPN13 Gene

(1) University of Copenhagen DISEASES for PTPN13 Gene

(15) Novoseek inferred disease relationships for PTPN13 Gene

Disease -log(P) Hits PubMed IDs
colon carcinoma 49.6 5
colon cancer 41.2 12
tumors 32.7 23
autoimmune thyroid disease 32.3 1
allelic loss 27.9 2

Relevant External Links for PTPN13

Genetic Association Database (GAD)
PTPN13
Human Genome Epidemiology (HuGE) Navigator
PTPN13
genes like me logo Genes that share disorders with PTPN13: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for PTPN13 Gene

Publications for PTPN13 Gene

  1. Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats. (PMID: 8287977) Maekawa K. … Harada S. (FEBS Lett. 1994) 2 3 4 23
  2. FAP-1: a protein tyrosine phosphatase that associates with Fas. (PMID: 7536343) Sato T. … Reed J.C. (Science 1995) 3 4 23
  3. Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins. (PMID: 7929060) Saras J. … Gonez L.J. (J. Biol. Chem. 1994) 3 4 23
  4. Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. (PMID: 10544233) Irie S. … Sato T.A. (FEBS Lett. 1999) 3 4 23
  5. Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1. (PMID: 14516276) Kimber W.A. … Alessi D.R. (Biochem. J. 2003) 3 4 23

Products for PTPN13 Gene

Sources for PTPN13 Gene

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