PTPN12 Gene
protein-coding GIFtS: 62
GCID: GC07P077166
|
|
protein tyrosine phosphatase, non-receptor type 12
| |
Aliases
for PTPN12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Tyrosine Phosphatase, Non-Receptor Type 121 2 | | PTPG11 2 3 5 | | PTP-PEST1 2 3 | | Protein-Tyrosine Phosphatase G12 3 | | Tyrosine-Protein Phosphatase Non-Receptor Type 122 | | EC 3.1.3.483 |
Export aliases for PTPN12 gene to outside databasesPrevious GC identifers: GC07P075702 GC07P076764 GC07P076778 GC07P076811 GC07P077004 GC07P071768 |
Summaries
for PTPN12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PTPN12:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signalingmolecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, andoncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interactiondomain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the productof the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, anddephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas),CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility.Alternative splicing results in multiple transcript variants encoding distinct isoforms. (provided by RefSeq, Oct2008)
UniProtKB/Swiss-Prot: PTN12_HUMAN, Q05209Function: Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling viaPTK2B/PYK2
Gene Wiki entry for PTPN12
|
Genomic Views
for PTPN12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PTPN12 gene promoter:
C/EBPbeta Ik-2 NF-E2 NF-E2 p45
Other transcription factors
Search SABiosciences Chromatin IP Primers for PTPN12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23PTPN12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P077166: view genomic region
(about GC identifiers)
Start:
|
77,166,592 bp from pter |
End:
|
77,269,388 bp from pter |
Size:
|
102,797 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 76,499,836-76,602,451 |
|
Proteins
for PTPN12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PTN12_HUMAN, Q05209 (See
protein sequence)Recommended Name: Tyrosine-protein phosphatase non-receptor type 12 Size: 780 amino acids; 88106 Da
Subunit: Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN(By similarity)
Subcellular location: Cytoplasm. Cell projection, podosome (By similarity)
Sequence caution: Sequence=BAD92761.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DKY2 E9PEH9 Q16130 Q59FD6 Q75MN8 Q86XU4Alternative splicing: 2 isoforms: Q05209-1 Q05209-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PTPN12: NX_Q05209
Post-translational modifications:
Phosphorylated by STK24/MST3 and this results in inhibition of its activity1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q05209
PTPN12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001124480.1 NP_001124481.1 NP_002826.3
ENSEMBL proteins: ENSP00000248594 ENSP00000428735 ENSP00000404050 ENSP00000392429 ENSP00000397991 ENSP00000392526 ENSP00000430726 ENSP00000413449 ENSP00000397364 ENSP00000385079
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
PTPN12 for ontologies About GeneDecksing
PTPN12 Antibody Products:
Assay Products for PTPN12: |
Protein
Domains /
Families
for PTPN12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PTPN12 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q05209ProtoNet protein and cluster: Q05209 1 Blocks protein family: IPB000242 Protein tyrosine phosphatase signature
UniProtKB/Swiss-Prot: PTN12_HUMAN, Q05209Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamilySimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function
for PTPN12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PTN12_HUMAN, Q05209Function: Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling viaPTK2B/PYK2Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate Genatlas biochemistry entry for PTPN12:protein tyrosine phosphatase non receptor type,88kDa,with PEST sequences (gastric 1)
Enzyme Number (IUBMB): EC 3.1.3.481
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN12 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN12 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): PTPN12 (NM_002835) | |  | Sino Biological Human cDNA Clone for PTPN12 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTPN12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN12 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
PTPN12 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Ptpn12tm1Mtr for PTPN12
9 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ptpn12):
PTPN12 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PTPN12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell Cycle / Checkpoint Control | | | 2 | Adhesion | | | 3 | EGFR1 Signaling Pathway | | | 4 | Phosphatases | | | 5 | GPCR Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTPN12
3 
Cell Signaling Technology (CST) Pathways for PTPN12
1  BioSystems Pathway for PTPN12
PTPN12 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/73 Interacting proteins for PTPN12 (Q052091, 2, 3 ENSP000002485944) via UniProtKB, MINT, STRING, and/or I2D (see all 73)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PDGFRB | P096191, 2, 3, ENSP000002617994 | EBI-2266035,EBI-641237 MINT-8312127 I2D:
score=1 STRING: ENSP00000261799 | | WAS | P427682, 3, ENSP000003658914 | MINT-50152 I2D:
score=4 STRING: ENSP00000365891 | | CSH1 | P012432, 3 | MINT-61776 I2D:
score=2 | | CSH2 | P012432, 3 | MINT-61776 I2D:
score=2 | | ERBB2 | P046261, 3, ENSP000002695714 | EBI-2266035,EBI-641062 I2D:
score=1 STRING: ENSP00000269571 |
About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006470 | protein dephosphorylation |
TAS | 8454633 |
PTPN12 for ontologies About GeneDecksing
|
Drugs & Compounds
for PTPN12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PTPN12 for compounds About GeneDecksing
 Browse Tocris compounds for PTPN12
1 HMDB Compound for PTPN12 About this table
6 Novoseek chemical compound relationships for PTPN12 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
70.7 |
36 |
10625692 (2), 17283076 (2), 11337490 (2), 10085298 (2) (see all 25) |
| proline |
51.3 |
8 |
10400685 (2), 18482983 (1), 10085298 (1), 19290936 (1) |
| serine |
45.9 |
8 |
12052829 (1), 17329398 (1), 18482983 (1), 17283076 (1) (see all 7) |
| phosphotyrosine |
43.4 |
3 |
10625692 (2), 9748319 (1) |
| threonine |
22.1 |
1 |
10085298 (1) |
| glutamate |
18.7 |
4 |
17329398 (1), 18482983 (1), 19290936 (1) |
Search CenterWatch for drugs/clinical trials and news about PTPN12 / PTN12
|
Transcripts
for PTPN12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PTPN12 gene (3 alternative transcripts): NM_001131008.1 NM_001131009.1 NM_002835.3 Unigene Cluster for PTPN12: Protein tyrosine phosphatase, non-receptor type 12 Hs.61812 [show with all ESTs]Unigene Representative Sequence: BC05000816 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000248594(uc003ugh.2 uc011kgp.1 uc011kgq.1 uc010lds.2)
ENST00000460731 ENST00000523952 ENST00000433369(uc010ldq.1 uc010ldr.1)
ENST00000415482 ENST00000435495 ENST00000418110 ENST00000522115 ENST00000440186
ENST00000447995 ENST00000481154 ENST00000494248 ENST00000464313 ENST00000407343
ENST00000520947 ENST00000519553
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN12 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN12 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): PTPN12 (NM_002835) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTPN12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN12 |
Additional cDNA sequence: AB209524.1 AK289573.1 AK296764.1 AK303602.1 AK314236.1 BC026004.1 BC050008.1 D13380.1 M93425.1 S69182.1 S69184.1 16 DOTS entries: DT.416963 DT.100822552 DT.436055 DT.91768775 DT.100822549 DT.102831075 DT.121054986 DT.91860448 DT.95195552 DT.121054958 DT.448490 DT.75173319 DT.91713736 DT.92024944 DT.99958870 DT.121054975 24/240 AceView cDNA sequences (see all 240): AV725740 BF438786 BG613998 BF969019 AA961712 BQ017969 BU623629 BM697625 BQ230780 BQ186912 AW948672 BM745237 AI867994 BM841138 BM973896 BU677881 BQ005902 NM_002835 BC026004 H88573 AL119589 M93425 CB148477 BQ773071
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PTPN12 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PTPN12
|
Expression
for PTPN12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PTPN12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGTTTCAG
About this image
See PTPN12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTPN12
SOURCE GeneReport for Unigene cluster: Hs.61812
SABiosciences Expression via Pathway-Focused PCR Array including PTPN12:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTPN12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN12 |
Orthologs
for PTPN12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PTPN12 gene from 5/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PTPN121 |
protein tyrosine phosphatase, non-receptor type 12 |
75.81(n)
75.68(a) |
|
417725 XM_415970.3 XP_415970.3 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.50602 |
Xenopus laevis transcribed sequence with moderate similarity more |
79.9(n) |
|
CA792202.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc658562 |
hypothetical protein MGC65856 |
71.7(n) |
|
393642 BC058051.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATPTP16 |
tyrosine phosphatase 1 |
22(a) |
1 → many |
1(27026711-27029092) |
rice
(Oryza sativa) |
Liliopsida |
---- |
Protein-tyrosine phosphatase domain containing pro...Protein-tyrosine phosphatase domain containing pro... |
24(a)19(a) |
many ↔ manymany ↔ many |
12(3791109-3796496) 11(4000708-4008336) |
ENSEMBL Gene Tree for PTPN12 (if available)
TreeFam Gene Tree for PTPN12 (if available) |
Paralogs
for PTPN12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PTPN12 gene
- PTPN72 PTPRH2 PTPN222 PTPRO2 PTPN112 PTPN62 PTPRJ2 PTPRQ2
- PTPN182 PTPN52 PTPRB2 PTPRR2
18/24 SIMAP similar genes for PTPN12 using alignment to 10 protein entries: PTN12_HUMAN (see all proteins)
(see all similar genes):PTPN22 PTPRF PTPN18 PTPRD DKFZp781C1038 BPTP-2
PTPRC PTPRS PTPN4 PTPRK PTPRO PTPRQ
PTPRA PTPRM PTPRN PTPN7 PTP PTPRZ1
PTPN12 for paralogs About GeneDecksing
|
Genomic Variants
for PTPN12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PTPN12 (77166592 - 77269388 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PTPN12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPN12 |
|
Disorders
/ Diseases
for PTPN12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PTPN12 for disorders About GeneDecksing
OMIM gene information: 600079
OMIM disorders: --
20  diseases for PTPN12: About MalaCardscharcot-marie-tooth disease distal hereditary motor neuropathy hypersensitivity reaction type ii disease wiskott-aldrich syndrome
connective tissue disease papa syndrome tooth disease plague
rheumatoid arthritis neuropathy breast cancer thyroid carcinoma
colon cancer ovarian cancer thyroiditis prostate cancer
prostatitis arthritis carcinoma neuronitis
3 Novoseek disease relationships for PTPN12 gene About this table
Human Genome Epidemiology (HuGE) Navigator: PTPN12 (3 documents)
Export disorders for PTPN12 gene to outside databases
|
Publications
for PTPN12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PTPN12 gene, integrated from 9 sources (see all 110):
(articles sorted by number of sources associating them with PTPN12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells. (PubMed id 7509295)1, 2, 3, 9 Takekawa M.... Yachi A. (1994)
- Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. (PubMed id 17329398)1, 2, 9 Sahu S.N....Gupta A. (2007)
- Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase. (PubMed id 8454633)1, 2, 9 Yang Q.... Tonks N.K. (1993)
- Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase. (PubMed id 8349645)1, 2, 9 Yang Q....Tonks N.K. (1993)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion. (PubMed id 9857189)1, 2 Li J.... Reinherz E.L. (1998)
- Cloning and characterization of a human cDNA encoding a novel putative cytoplasmic protein-tyrosine-phosphatase. (PubMed id 1472029)1, 2 Takekawa M.... Yachi A. (1992)
|
External Searches for PTPN12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PTPN12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PTPN12 gene
(According to HUGE)
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Specialized Databases showing PTPN12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for PTPN12 gene:
Search GeneIP for patents involving PTPN12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PTPN12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PTPN12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN12 | | | OriGene Protein Over-expression Lysate for PTPN12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PTPN12 | | OriGene 3'-UTR Clone for PTPN12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PTPN12 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PTPN12 | | OriGene Custom Protein Services for PTPN12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTPN12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPN12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN12 |
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| | Antibodies & Assays for PTPN12 (PTP-PEST) |
| | | | Search Tocris compounds for PTPN12 |
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 | | | PTPN12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN12 |
|  |  |  | | | | ThermoFisher Antibodies for PTPN12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN12 |
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