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Aliases for PTPN12 Gene

Aliases for PTPN12 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 12 2 3 5
  • Protein-Tyrosine Phosphatase G1 3 4
  • PTP-PEST 3 4
  • PTPG1 3 4
  • EC 3.1.3.48 4

External Ids for PTPN12 Gene

Previous GeneCards Identifiers for PTPN12 Gene

  • GC07P075702
  • GC07P076764
  • GC07P076778
  • GC07P076811
  • GC07P077004
  • GC07P077166
  • GC07P071768

Summaries for PTPN12 Gene

Entrez Gene Summary for PTPN12 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

GeneCards Summary for PTPN12 Gene

PTPN12 (Protein Tyrosine Phosphatase, Non-Receptor Type 12) is a Protein Coding gene. Diseases associated with PTPN12 include Colorectal Cancer. Among its related pathways are GPCR Pathway and DNA Damage. GO annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRO.

UniProtKB/Swiss-Prot for PTPN12 Gene

  • Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.

Gene Wiki entry for PTPN12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN12 Gene

Genomics for PTPN12 Gene

Regulatory Elements for PTPN12 Gene

Enhancers for PTPN12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTPN12 on UCSC Golden Path with GeneCards custom track

Promoters for PTPN12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTPN12 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPN12 Gene

Chromosome:
7
Start:
77,537,275 bp from pter
End:
77,640,071 bp from pter
Size:
102,797 bases
Orientation:
Plus strand

Genomic View for PTPN12 Gene

Genes around PTPN12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN12 Gene

Proteins for PTPN12 Gene

  • Protein details for PTPN12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05209-PTN12_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 12
    Protein Accession:
    Q05209
    Secondary Accessions:
    • A4D1C5
    • B4DKY2
    • E9PBR5
    • E9PEH9
    • Q16130
    • Q59FD6
    • Q75MN8
    • Q86XU4

    Protein attributes for PTPN12 Gene

    Size:
    780 amino acids
    Molecular mass:
    88106 Da
    Quaternary structure:
    • Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN (By similarity). Interacts with SORBS2; this interaction greatly enhances WASF1 dephosphorylation and may mediate partial to focal adhesion sites.
    SequenceCaution:
    • Sequence=BAD92761.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PTPN12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPN12 Gene

Proteomics data for PTPN12 Gene at MOPED

Post-translational modifications for PTPN12 Gene

  • Phosphorylated by STK24/MST3 and this results in inhibition of its activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTPN12 (PTP-PEST)

No data available for DME Specific Peptides for PTPN12 Gene

Domains & Families for PTPN12 Gene

Gene Families for PTPN12 Gene

Graphical View of Domain Structure for InterPro Entry

Q05209

UniProtKB/Swiss-Prot:

PTN12_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
genes like me logo Genes that share domains with PTPN12: view

Function for PTPN12 Gene

Molecular function for PTPN12 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase non receptor type,88kDa,with PEST sequences (gastric 1)
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.

Enzyme Numbers (IUBMB) for PTPN12 Gene

Gene Ontology (GO) - Molecular Function for PTPN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS 8454633
GO:0005515 protein binding IPI 9285683
genes like me logo Genes that share ontologies with PTPN12: view
genes like me logo Genes that share phenotypes with PTPN12: view

Human Phenotype Ontology for PTPN12 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPN12 Gene

MGI Knock Outs for PTPN12:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPN12

No data available for Transcription Factor Targets and HOMER Transcription for PTPN12 Gene

Localization for PTPN12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN12 Gene

Cytoplasm. Cell junction, focal adhesion. Cell projection, podosome. Note=Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2. {ECO:0000269 PubMed:18559503}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPN12 Gene COMPARTMENTS Subcellular localization image for PTPN12 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
cytosol 4
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PTPN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PTPN12: view

Pathways & Interactions for PTPN12 Gene

genes like me logo Genes that share pathways with PTPN12: view

Pathways by source for PTPN12 Gene

3 Cell Signaling Technology pathways for PTPN12 Gene
1 BioSystems pathway for PTPN12 Gene
2 Qiagen pathways for PTPN12 Gene

SIGNOR curated interactions for PTPN12 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PTPN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,TAS 8454633
genes like me logo Genes that share ontologies with PTPN12: view

Drugs & Compounds for PTPN12 Gene

(4) Drugs for PTPN12 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for PTPN12 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTPN12: view

Transcripts for PTPN12 Gene

Unigene Clusters for PTPN12 Gene

Protein tyrosine phosphatase, non-receptor type 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PTPN12 Gene

GeneLoc Exon Structure for
PTPN12
ECgene alternative splicing isoforms for
PTPN12

Expression for PTPN12 Gene

mRNA expression in normal human tissues for PTPN12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPN12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Lavage (13.4), Platelet (8.5), and NK cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN12 Gene



SOURCE GeneReport for Unigene cluster for PTPN12 Gene Hs.61812

genes like me logo Genes that share expression patterns with PTPN12: view

Protein tissue co-expression partners for PTPN12 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTPN12 Gene

Orthologs for PTPN12 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPN12 35
  • 91.9 (n)
  • 90.36 (a)
PTPN12 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPN12 35
  • 92.55 (n)
  • 91.57 (a)
PTPN12 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpn12 35
  • 85.06 (n)
  • 84.5 (a)
Ptpn12 16
Ptpn12 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPN12 35
  • 99.87 (n)
  • 99.62 (a)
PTPN12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpn12 35
  • 84.66 (n)
  • 85.49 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPN12 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPN12 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPN12 35
  • 75.77 (n)
  • 75.68 (a)
PTPN12 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 12 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn12 35
  • 68.69 (n)
  • 69.57 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5060 35
zebrafish
(Danio rerio)
Actinopterygii ptpn12 35
  • 64.95 (n)
  • 69.79 (a)
zgc65856 35
worm
(Caenorhabditis elegans)
Secernentea C17H12.3 37
  • 31 (a)
C55B7.3 37
  • 30 (a)
F10G8.1 37
  • 29 (a)
F36H1.3 37
  • 32 (a)
F47B3.1 37
  • 35 (a)
F47B3.6 37
  • 35 (a)
F47B3.7 37
  • 33 (a)
K07F5.8 37
  • 34 (a)
M04G7.2 37
  • 35 (a)
Y41D4A.5 37
  • 33 (a)
ZK484.7 37
  • 29 (a)
ZK616.7 37
  • 34 (a)
Y41D4A.5 36
  • 27 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1482 35
Species with no ortholog for PTPN12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN12 Gene

ENSEMBL:
Gene Tree for PTPN12 (if available)
TreeFam:
Gene Tree for PTPN12 (if available)

Paralogs for PTPN12 Gene

Paralogs for PTPN12 Gene

genes like me logo Genes that share paralogs with PTPN12: view

Variants for PTPN12 Gene

Sequence variations from dbSNP and Humsavar for PTPN12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_006385 Colon cancer
rs9640663 - 77,618,504(+) ACATG(A/G)TCAGC reference, missense
rs3750050 - 77,627,396(+) GTCCT(A/G)CAACA reference, missense
rs2230602 - 77,635,823(+) GTCAG(A/G)AACGA reference, missense
rs917787 -- 77,561,549(+) TATAG(C/T)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPN12 Gene

Variant ID Type Subtype PubMed ID
nsv831039 CNV Gain 17160897
esv1494265 CNV Insertion 17803354
esv2734701 CNV Deletion 23290073

Variation tolerance for PTPN12 Gene

Residual Variation Intolerance Score: 9.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.75; 83.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPN12 Gene

Human Gene Mutation Database (HGMD)
PTPN12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN12 Gene

Disorders for PTPN12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTPN12 Gene - From: OMIM and ClinVar

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PTPN12

Genetic Association Database (GAD)
PTPN12
Human Genome Epidemiology (HuGE) Navigator
PTPN12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPN12
genes like me logo Genes that share disorders with PTPN12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPN12 Gene

Publications for PTPN12 Gene

  1. Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells. (PMID: 7509295) Takekawa M. … Yachi A. (FEBS Lett. 1994) 2 3 4 23 67
  2. Protein phosphatase 1alpha associates with protein tyrosine phosphatase-PEST inducing dephosphorylation of phospho-serine 39. (PMID: 19919952) Nakamura K. … Mashima K. (J. Biochem. 2010) 3 23
  3. Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response. (PMID: 17130234) HallAc M. … Tremblay M.L. (Mol. Cell. Biol. 2007) 3 23
  4. Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. (PMID: 17329398) Sahu S.N. … Gupta A. (Am. J. Physiol. 2007) 3 23
  5. Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases. (PMID: 15831474) Schmidt-Arras D.E. … Bohmer F.D. (Mol. Cell. Biol. 2005) 3 23

Products for PTPN12 Gene

Sources for PTPN12 Gene

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