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Aliases for PTPN12 Gene

Aliases for PTPN12 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 12 2 3
  • PTPG1 3 4 6
  • Protein-Tyrosine Phosphatase G1 3 4
  • PTP-PEST 3 4
  • Tyrosine-Protein Phosphatase Non-Receptor Type 12 3
  • EC 4

External Ids for PTPN12 Gene

Summaries for PTPN12 Gene

Entrez Gene Summary for PTPN12 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

GeneCards Summary for PTPN12 Gene

PTPN12 (Protein Tyrosine Phosphatase, Non-Receptor Type 12) is a Protein Coding gene. Diseases associated with PTPN12 include colorectal cancer. Among its related pathways are GPCR Pathway and PAK Pathway. GO annotations related to this gene include SH3 domain binding and non-membrane spanning protein tyrosine phosphatase activity. An important paralog of this gene is PTPN6.

UniProtKB/Swiss-Prot for PTPN12 Gene

  • Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.

Gene Wiki entry for PTPN12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN12 Gene

Genomics for PTPN12 Gene

Genomic Location for PTPN12 Gene

77,537,275 bp from pter
77,640,071 bp from pter
102,797 bases
Plus strand

Genomic View for PTPN12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN12 Gene

Regulatory Elements for PTPN12 Gene

Proteins for PTPN12 Gene

  • Protein details for PTPN12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 12
    Protein Accession:
    Secondary Accessions:
    • A4D1C5
    • B4DKY2
    • E9PBR5
    • E9PEH9
    • Q16130
    • Q59FD6
    • Q75MN8
    • Q86XU4

    Protein attributes for PTPN12 Gene

    780 amino acids
    Molecular mass:
    88106 Da
    Quaternary structure:
    • Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN (By similarity).
    • Sequence=BAD92761.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PTPN12 Gene


neXtProt entry for PTPN12 Gene

Proteomics data for PTPN12 Gene at MOPED

Post-translational modifications for PTPN12 Gene

  • Phosphorylated by STK24/MST3 and this results in inhibition of its activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PTPN12 Gene

Domains for PTPN12 Gene

Gene Families for PTPN12 Gene

  • PTPN :Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor


  • Contains 1 tyrosine-protein phosphatase domain.:
    • Q05209
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.:
    • Q05209
genes like me logo Genes that share domains with PTPN12: view

Function for PTPN12 Gene

Molecular function for PTPN12 Gene

GENATLAS Biochemistry: protein tyrosine phosphatase non receptor type,88kDa,with PEST sequences (gastric 1)
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.

Enzyme Numbers (IUBMB) for PTPN12 Gene

Gene Ontology (GO) - Molecular Function for PTPN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004725 protein tyrosine phosphatase activity --
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS 8454633
GO:0005515 protein binding IPI 12614164
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPN12: view
genes like me logo Genes that share phenotypes with PTPN12: view

Animal Models for PTPN12 Gene

MGI Knock Outs for PTPN12:

miRNA for PTPN12 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for PTPN12 Gene

Localization for PTPN12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN12 Gene

Cytoplasm. Cell projection, podosome.

Subcellular locations from

Jensen Localization Image for PTPN12 Gene COMPARTMENTS Subcellular localization image for PTPN12 gene
Compartment Confidence
plasma membrane 4
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PTPN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IDA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with PTPN12: view

Pathways for PTPN12 Gene

genes like me logo Genes that share pathways with PTPN12: view

Pathways by source for PTPN12 Gene

2 Qiagen pathways for PTPN12 Gene
3 Cell Signaling Technology pathways for PTPN12 Gene
1 BioSystems pathway for PTPN12 Gene

Gene Ontology (GO) - Biological Process for PTPN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 8454633
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 8454633
genes like me logo Genes that share ontologies with PTPN12: view

Compounds for PTPN12 Gene

(1) HMDB Compounds for PTPN12 Gene

Compound Synonyms Cas Number PubMed IDs
  • NFB Orthophosphate

(6) Novoseek inferred chemical compound relationships for PTPN12 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 70.7 32
proline 51.3 5
serine 45.9 7
phosphotyrosine 43.4 3
threonine 22.1 1
genes like me logo Genes that share compounds with PTPN12: view

Transcripts for PTPN12 Gene

Unigene Clusters for PTPN12 Gene

Protein tyrosine phosphatase, non-receptor type 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20
SP1: -
SP2: -
SP3: -

Relevant External Links for PTPN12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPN12 Gene

mRNA expression in normal human tissues for PTPN12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN12 Gene

SOURCE GeneReport for Unigene cluster for PTPN12 Gene Hs.61812

genes like me logo Genes that share expressions with PTPN12: view

Orthologs for PTPN12 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTPN12 36
  • 99.87 (n)
  • 99.62 (a)
PTPN12 37
  • 100 (a)
(Bos Taurus)
Mammalia PTPN12 36
  • 91.9 (n)
  • 90.36 (a)
PTPN12 37
  • 89 (a)
(Canis familiaris)
Mammalia PTPN12 36
  • 92.55 (n)
  • 91.57 (a)
PTPN12 37
  • 91 (a)
(Mus musculus)
Mammalia Ptpn12 36
  • 85.06 (n)
  • 84.5 (a)
Ptpn12 16
Ptpn12 37
  • 85 (a)
(Monodelphis domestica)
Mammalia PTPN12 37
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia PTPN12 37
  • 78 (a)
(Rattus norvegicus)
Mammalia Ptpn12 36
  • 84.66 (n)
  • 85.49 (a)
(Gallus gallus)
Aves PTPN12 36
  • 75.77 (n)
  • 75.68 (a)
PTPN12 37
  • 74 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 12 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5060 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn12 36
  • 68.69 (n)
  • 69.57 (a)
(Danio rerio)
Actinopterygii ptpn12 36
  • 64.95 (n)
  • 69.79 (a)
zgc65856 36
(Caenorhabditis elegans)
Secernentea Y41D4A.5 37
  • 27 (a)
ZK616.7 38
  • 34 (a)
F47B3.6 38
  • 35 (a)
K07F5.8 38
  • 34 (a)
Y41D4A.5 38
  • 33 (a)
C55B7.3 38
  • 30 (a)
F47B3.1 38
  • 35 (a)
F10G8.1 38
  • 29 (a)
M04G7.2 38
  • 35 (a)
F36H1.3 38
  • 32 (a)
ZK484.7 38
  • 29 (a)
C17H12.3 38
  • 31 (a)
F47B3.7 38
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1482 36
Species with no ortholog for PTPN12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN12 Gene

Gene Tree for PTPN12 (if available)
Gene Tree for PTPN12 (if available)

Paralogs for PTPN12 Gene

genes like me logo Genes that share paralogs with PTPN12: view

Variants for PTPN12 Gene

Sequence variations from dbSNP and Humsavar for PTPN12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs13995 -- 77,639,736(+) TGCCC(C/T)GGAGT utr-variant-3-prime
rs917787 -- 77,561,549(+) TATAG(C/T)GGTCA intron-variant
rs969263 -- 77,550,398(+) ATAGA(C/T)TAAAA intron-variant
rs1011307 -- 77,591,585(-) TAAAA(C/G)CCCTA intron-variant
rs1024723 -- 77,606,831(+) ccaga(C/T)ggact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPN12 Gene

Variant ID Type Subtype PubMed ID
nsv831039 CNV Gain 17160897
esv1494265 CNV Insertion 17803354
esv2734701 CNV Deletion 23290073

Relevant External Links for PTPN12 Gene

HapMap Linkage Disequilibrium report

Disorders for PTPN12 Gene

(1) OMIM Diseases for PTPN12 Gene (600079)

(1) MalaCards Diseases for PTPN12 Gene

Search for PTPN12 Gene in MalaCards »

(4) University of Copenhagen DISEASES for PTPN12 Gene

(3) Novoseek inferred disease relationships for PTPN12 Gene

Disease -log(P) Hits PubMed IDs
metastasis 3.36 2
breast cancer 0 1
cancer 0 2

Relevant External Links for PTPN12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PTPN12: view

No data available for UniProtKB/Swiss-Prot for PTPN12 Gene

Publications for PTPN12 Gene

  1. Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells. (PMID: 7509295) Takekawa M. … Yachi A. (FEBS Lett. 1994) 2 3 4 23
  2. Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase. (PMID: 8349645) Yang Q. … Tonks N.K. (J. Biol. Chem. 1993) 3 4 23
  3. Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase. (PMID: 8454633) Yang Q. … Tonks N.K. (J. Biol. Chem. 1993) 3 4 23
  4. Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. (PMID: 17329398) Sahu S.N. … Gupta A. (Am. J. Physiol. 2007) 3 4 23
  5. Identification of protein tyrosine phosphatases associating with the PDGF receptor. (PMID: 12614164) Markova B. … BAPhmer F.D. (Biochemistry 2003) 3 23

Products for PTPN12 Gene

Sources for PTPN12 Gene

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