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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PTPN11 Gene

protein-coding GIFtS: 73
GCID: GC12P112856

protein tyrosine phosphatase, non-receptor type 11

(Previous name: Noonan syndrome 1 )
(Previous symbol: NS1)

Explore 117 diseases affiliated with
PTPN11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 11¹ ²		PTP-1D² ³
PTP2C¹ ² ³ ⁵		PTP-2C² ³
SH-PTP2¹ ² ³		SH-PTP3² ³
NS1¹ ² ⁵		EC 3.1.3.48³ ⁸
SHP2¹ ² ⁵		Noonan Syndrome 1¹
BPTP3¹ ²		CFC²
SHP-2¹ ³		Tyrosine-Protein Phosphatase Non-Receptor Type 11²
Protein-Tyrosine Phosphatase 1D² ³		SHPTP2³
Protein-Tyrosine Phosphatase 2C² ³		Shp2³

External Ids:	HGNC: 9644¹	Entrez Gene: 5781²	Ensembl: ENSG00000179295⁷	OMIM: 176876⁵	UniProtKB: Q06124³

Export aliases for PTPN11 gene to outside databases

Previous GC identifers: GC12P111712 GC12P112333 GC12P112639 GC12P111268 GC12P111319 GC12P109868

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPN11:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be

signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic

cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as

phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely

expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a

diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell

migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124

Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal

transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its

RhoA binding activity

summary for PTPN11:

Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups

from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of

kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. PTPs

are cysteine-dependent phosphatases that contain a conserved C[X]5R motif essential for enzymatic activity.

PTPs are currently divided into five subtypes; tyrosine-specific phosphatases (e.g. PTP1B), dual specificity

phosphatases (DSPs) (e.g. DUSP1), Cdc25 phosphatases (e.g. Cdc25A), myotubularin-related phosphatases (e.g.

MTMR13) and low molecular weight phosphatases (e.g. PTPase A). Perturbations in PTP activity has been

implicated in human diseases, including type II diabetes. PTPs have been identified as a negative regulator

of the insulin signaling by dephosphorylating phosphotyrosine residues of insulin receptor kinase. In

cancers, PTPs dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation.

Gene Wiki entry for PTPN11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009775.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTPN11 gene promoter:
AP-2alpha isoform 3 STAT3 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTPN11 promoter sequence

Search SABiosciences Chromatin IP Primers for PTPN11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24 Ensembl cytogenetic band: 12q24.13 HGNC cytogenetic band: 12q24.1

PTPN11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN11 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P112856: view genomic region (about GC identifiers)

Start:	112,856,155 bp from pter	End:	112,947,717 bp from pter
Size:	91,563 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124 (See protein sequence)

Recommended Name: Tyrosine-protein phosphatase non-receptor type 11

Size: 597 amino acids; 68436 Da

Subunit: Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB and INPP5D/SHIP1 (By similarity). Interacts

with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3 (tyrosine-phosphorylated),

FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine phosphorylated). Interacts (via SH2

domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with PTPNS1 and CD84. Interacts with

phosphorylated SIT1 and MPZL1. Interacts with FCRL3, FCRL4, FCRL6 and ANKHD1. Interacts with KIR2DL1; the interaction

is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT; the interaction retains TERT in the nucleus. Interacts

with PECAM1 and FER. Interacts with EPHA2 (activated); participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream

signaling. Interacts with ROS1; mediates PTPN11 phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this

interaction increases the PTPN11 phosphatase activity. Interacts with GAREM isoform 1 (tyrosine phosphorylated); the

interaction increases MAPK/ERK activity and does not affect the GRB2/SOS complex formation

Subcellular location: Cytoplasm

6 PDB 3D structures from and Proteopedia for PTPN11:

2SHP (3D)

3B7O (3D)

3MOW (3D)

3O5X (3D)

3TKZ (3D)

3TL0 (3D)

Secondary accessions: A8K1D9 Q96HD7

Alternative splicing: 3 isoforms: Q06124-1 Q06124-2 Q06124-3

Explore the universe of human proteins at neXtProt for PTPN11: NX_Q06124

Post-translational modifications:

Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site

for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3.

Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q06124

4/20 DME Specific Peptides for PTPN11 (Q06124) (see all 20)

WPDHGVP

SRRWFHP

DPTSERW

VVHCSAG

PTPN11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_002825.3 NP_542168.1

ENSEMBL proteins:

ENSP00000376376 ENSP00000340944 ENSP00000437013

Reactome Protein details: Q06124
Human Recombinant Protein Products for PTPN11:

	EMD Millipore Purified and/or Recombinant PTPN11 Protein
	R&D Systems Recombinant & Natural Proteins for PTPN11 (SHP-2)
	Enzo Life Sciences proteins for PTPN11
	OriGene Purified Protein: PTPN11 Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for PTPN11
	GenScript Custom Purified and Recombinant Proteins Services for PTPN11
	Novus Biologicals PTPN11 Proteins Novus Biologicals PTPN11 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PTPN11

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	IDA	10940933
GO:0005739	mitochondrion	IEA	--
GO:0005829	cytosol	TAS	--
GO:0043234	protein complex	IEA	--

PTPN11 for ontologies About GeneDecksing

PTPN11 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PTPN11
	R&D Systems Antibodies for PTPN11 (SHP-2)
	Cell Signaling Technology (CST) Antibodies for PTPN11 (SHP-2)
	OriGene Antibodies (see all 11): PTPN11 OriGene Custom Antibody Services for PTPN11
	GenScript Custom Superior Antibodies Services for PTPN11
	Novus Biologicals PTPN11 Antibodies
	Abcam antibodies for PTPN11
	Uscn Antibodies for PTPN11
	ThermoFisher Antibodies for PTPN11

Assay Products for PTPN11:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for PTPN11 (SHP-2) (see all)
	GenScript Custom Assay Services for PTPN11
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PTPN11

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTPN11 for domains About GeneDecksing

5 InterPro domains/families:

IPR016130 Tyr_Pase_AS

IPR000242 Tyr_Pase_rcpt/non-rcpt

IPR000387 Tyr/Dual-sp_Pase

IPR000980 SH2

IPR012152 Tyr_Pase_non-rcpt_typ-6/11

Graphical View of Domain Structure for InterPro Entry Q06124

ProtoNet protein and cluster: Q06124

2 Blocks protein families:

IPB000242 Protein tyrosine phosphatase signature

IPB000980 SH2 domain signature

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124

Domain: The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing proteins

relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily

Similarity: Contains 2 SH2 domains

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PTN11_HUMAN, Q06124

Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal

transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its

RhoA binding activity

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Genatlas biochemistry entry for PTPN11:

protein tyrosine phosphatase,non receptor type 11,with two SH2 domains,expressed in heart,brain,skeletal muscle with

homology to Drosophila corkscrew,involved in intracellular signal transduction in response to

PDGF,EGF,insulin,interacting with protein zero related (PZR) for cell signaling,overexpressed in neutrophils cells

from patients with severe congenital neutropenia (defective dephosphorylation of proteins involved in signaling

pathways)

Enzyme Number (IUBMB): EC 3.1.3.48¹ ²

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004721	phosphoprotein phosphatase activity	--	--
GO:0004725	protein tyrosine phosphatase activity	TAS	--
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	TAS	--
GO:0005070	SH3/SH2 adaptor activity	IDA	7493946
GO:0005158	insulin receptor binding	IPI	7493946

PTPN11 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for PTPN11:

Decreased focal adhesion (FA)

Increased cell death in breast

Increased cell number in G2M,

Upregulation of Wnt/beta-caten

15/26 MGI mutant phenotypes (inferred from 16 alleles) (MGI details for Ptpn11) (see all 26):

adipose tissue	cardiovascular system	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system

PTPN11 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for PTPN11: Ptpn11^tm1Rbn Ptpn11^tm2Bgn Ptpn11^tm1.2Cbm Ptpn11^tm1Paw

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PTPN11

miRNA Products:		miRTarBase miRNAs that target PTPN11: hsa-mir-489 (MIRT003549)

		OriGene 3'-UTR Clone: PTPN11 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN11
		8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN11 (see all 92):
		hsa-miR-26a-2* hsa-miR-607 hsa-miR-1260b hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3916 hsa-miR-489

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN11 (see all 7) OriGene shRNA RFP: PTPN11 OriGene siRNA: PTPN11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN11
		Sirion Biotech Custom design and validation of potent shRNA sequences against PTPN11

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PTPN11
			Sirion Biotech Customized adenovirus for overexpression of PTPN11 Sirion Biotech Customized adenovirus for potent knockdown of PTPN11

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PTPN11 (NM_002834)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PTPN11
		Search LifeMap BioReagents cell lines for PTPN11
		Sirion Biotech Customized stable knockdown cell line services for PTPN11 Sirion Biotech Customized inducible knockdown cell line services for PTPN11 Sirion Biotech Customized stable overexpressing cell line services for PTPN11 Sirion Biotech Customized inducible overexpressing cell line services for PTPN11

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN11

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/88 super-pathways (see all 88) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

Development_CNTF receptor signaling

8/9 pathways (see all 9)
Development_CNTF receptor signaling	1.00	Immune response_IL-6 signaling pathway	0.30
Development CNTF receptor signaling	1.00	Immune response IL-6 signaling pathway	0.30
Development_Growth hormone signaling via PI3K/AKT and MAPK cascades	0.34	Development_Leptin signaling via JAK/STAT and MAPK cascades	0.25
Development Growth hormone signaling via PI3K/AKT and MAPK cascades	0.34	Development Leptin signaling via JAK/STAT and MAPK cascades	0.25

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	PI3K Cascade	0.84
IRS-related events triggered by IGF1R	0.93	Signaling by Insulin receptor	0.74

Development HGF signaling pathway

Development_Neurotrophin family signaling	0.45	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	0.23
Development Neurotrophin family signaling	0.45	Neurotrophin signaling pathway	0.20
Signaling of Hepatocyte Growth Factor Receptor	0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

5/22 EMD Millipore Pathways for PTPN11 (see all 22)

	Chemotaxis CXCR4 signaling pathway
	Development Leptin signaling via JAK/STAT and MAPK cascades
	Immune response Role of DAP12 receptors in NK cells
	Immune response IL-2 activation and signaling pathway
	Development Growth hormone signaling via PI3K/AKT and MAPK cascades

1 R&D Systems Pathway for PTPN11

Adipocytokines & Insulin Signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPN11

Epithelial Adherens Junctions

3 Cell Signaling Technology (CST) Pathways for PTPN11

	Phosphatases
	MAP Kinase Signaling
	Apoptosis and Autophagy

5/24 GeneGo (Thomson Reuters) Pathways for PTPN11 (see all 24)

	Development Leptin signaling via JAK/STAT and MAPK cascades
	Development FGF-family signaling
	Development CNTF receptor signaling
	Development Thrombopoetin signaling via JAK-STAT pathway
	Chemotaxis CXCR4 signaling pathway

5/44 BioSystems Pathways for PTPN11 (see all 44)

	Oncostatin M Signaling Pathway
	EGFR1 Signaling Pathway
	Heart Development
	Type II interferon signaling (IFNG)
	IL-3 Signaling Pathway

5/67 Reactome Pathways for PTPN11 (see all 67)

	Platelet homeostasis
	Prolactin receptor signaling
	Regulation of IFNG signaling
	IRS-mediated signalling
	Signaling by PDGF

5/8 Kegg Pathways (Kegg details for PTPN11) (see all 8):

	Jak-STAT signaling pathway
	Natural killer cell mediated cytotoxicity
	Leukocyte transendothelial migration
	Neurotrophin signaling pathway
	Adipocytokine signaling pathway

PTPN11 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTPN11

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/329 Interacting proteins for PTPN11 (Q06124^{1, 2, 3} ENSP00000340944⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 329)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GAB1	Q13480¹^,²^,³, ENSP00000262995⁴	EBI-297779,EBI-517684 MINT-6169355 MINT-6169300 MINT-6169451 MINT-6169344 MINT-8025571 MINT-8029574 MINT-6169406 MINT-6169374 MINT-8029606 MINT-8288652 MINT-8025555 MINT-7026140 MINT-6169338 MINT-6169389 MINT-6169309 MINT-6169327 MINT-6169291 MINT-8029590 I2D: score=10 STRING: ENSP00000262995
GRB2	P62993¹^,²^,³, ENSP00000339007⁴	EBI-297779,EBI-401755 MINT-7300447 MINT-61552 I2D: score=11 STRING: ENSP00000339007
PECAM1	P16284²^,³	MINT-8033280 MINT-8033310 MINT-8031339 MINT-8033235 MINT-8031324 MINT-8031354 MINT-8033295 I2D: score=3
CCKBR	P32239²^,³, ENSP00000335544⁴	MINT-3381499 MINT-3381756 MINT-8037752 MINT-3381410 MINT-3381872 I2D: score=2 STRING: ENSP00000335544
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-61484 MINT-61492 MINT-61488 MINT-74689 I2D: score=6 STRING: ENSP00000275493

About this table

Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000077	DNA damage checkpoint	IEA	--
GO:0000187	activation of MAPK activity	IEA	--
GO:0006470	protein dephosphorylation	--	--
GO:0006629	lipid metabolic process	--	--
GO:0006641	triglyceride metabolic process	IEA	--

PTPN11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PTPN11 for compounds About GeneDecksing

EMD Millipore small molecules for PTPN11:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for PTPN11

Compounds for PTPN11 available from Tocris Bioscience About this table

Compound	Action	CAS #
NSC 87877	Potent inhibitor of shp2 and shp1 PTP	[56990-57-9]

2 HMDB Compounds for PTPN11 About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

1 DrugBank Compound for PTPN11 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Dodecane-Trimethylamine	--	--	target	--	17139284 17016423 10592235

10/59 Novoseek chemical compound relationships for PTPN11 gene (see all 59) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	89.3	917	9129156 (6), 9582366 (6), 7629070 (6), 19275884 (5) (see all 99)
phosphotyrosine	82	54	12731888 (2), 11684012 (2), 7681217 (1), 8890167 (1) (see all 41)
gp 130	72.8	61	10946280 (4), 12593670 (4), 9285712 (3), 12403768 (3) (see all 26)
phosphatidylinositol	69.5	62	9632795 (3), 8647870 (3), 9565634 (2), 10397152 (2) (see all 45)
phenylalanine	47.8	12	8622663 (1), 8943348 (1), 9756938 (1), 8959326 (1) (see all 10)
phenylarsine oxide	47.7	2	7935386 (1)
inositol	46.3	17	10651806 (1), 11709085 (1), 10623804 (1), 17984366 (1) (see all 16)
ly294002	44.4	2	14762163 (1), 11335710 (1)
sodium orthovanadate	42.6	1	10540326 (1)
echistatin	41.1	5	12399420 (3), 16195423 (1)

Search CenterWatch for drugs/clinical trials and news about PTPN11 / PTN11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PTPN11 gene (2 alternative transcripts):

NM_002834.3 NM_080601.1

Unigene Cluster for PTPN11:

Protein tyrosine phosphatase, non-receptor type 11

Hs.506852 [show with all ESTs]

Unigene Representative Sequence: NM_002834

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000531326 ENST00000392597(uc001ttw.1) ENST00000351677(uc001ttx.3)

ENST00000530818

miRNA Products:		OriGene 3'-UTR Clone: PTPN11 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN11
		8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN11 (see all 92):
		hsa-miR-26a-2* hsa-miR-607 hsa-miR-1260b hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3916 hsa-miR-489

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN11 (see all 7) OriGene shRNA RFP: PTPN11 OriGene siRNA: PTPN11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN11
		Sirion Biotech Custom design and validation of potent shRNA sequences against PTPN11

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PTPN11 (NM_002834)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTPN11
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN11

Additional cDNA sequence:

AK289854.1 AK312147.1 BC007869.2 BC008692.1 BC025181.1 BC030949.1 BT007106.1 BX537632.1

D13540.1 EU779706.1 EU779707.1 EU779708.1 L03535.1 L07527.1 L08807.1 S78088.1

U79291.1 X70766.1

18 DOTS entries:

DT.411692 DT.99944225 DT.100733832 DT.91769243 DT.100656212 DT.121153732 DT.95354784 DT.121153765

DT.120647580 DT.70100615 DT.95127024 DT.100783460 DT.121153563 DT.121153748 DT.91871508 DT.92421803

DT.120843678 DT.99974908

24/1484 AceView cDNA sequences (see all 1484):

CR605343 CD049940 BF102663 BG742360 BF365510 BF037064 CB122576 AV712841

BE542112 BE886762 BM550524 AA765096 BG898041 AA341207 BG284893 BI830346

BM794666 CD651903 AA364282 AA313299 BM873857 CB123159 AA382251 BE740256

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PTPN11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATGTTGA

About this image
See PTPN11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTPN11

SOURCE GeneReport for Unigene cluster: Hs.506852

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124

Tissue specificity: Widely expressed, with highest levels in heart, brain, and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including PTPN11:

Multiple Sclerosis in human mouse rat

PI3K-AKT Signaling Pathway in human mouse rat

Protein Phosphatases in human mouse rat

Huntington's Disease in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTPN11
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN11

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PTPN11 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PTPN11¹	protein tyrosine phosphatase, non-receptor type 11	85.33(n) 98.31(a)		395815 NM_204968.1 NP_990299.1
lizard (Anolis carolinensis)	Reptilia	PTPN11⁶	--	97(a)	1 ↔ 1	GL343282.1(325780-343622)
African clawed frog (Xenopus laevis)	Amphibia	Xl.936²	Xenopus laevis phosphotyrosyl-protein phosphatase mRNA, more	82.68(n)		U15287.1
zebrafish (Danio rerio)	Actinopterygii	wufi24f03²	wufi24f03	78.16(n)		333979 BC045328.1
fruit fly (Drosophila melanogaster)	Insecta	csw^{1 , 3}	EGF receptor signaling pathway protein tyrosine more³ corkscrew¹	66(a)³ 60.95(n)¹ 66.1(a)¹		45278¹ NM_057782.3¹ NP_477130.1¹
worm (Caenorhabditis elegans)	Secernentea	ptp-2^{1 , 3}	PROTEIN-TYROSINE PHOSPHATASE³ Protein Tyrosine Phosphatase¹	37(a) (best of 3)³ 50.63(n)¹ 44.31(a)¹		II(5918677-5920933)³ 174003¹ NM_062783.4¹ NP_495184.1¹

ENSEMBL Gene Tree for PTPN11 (if available)
TreeFam Gene Tree for PTPN11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PTPN11 gene

PTPN7² PTPRH² PTPN22² PTPRO² PTPN6² PTPRJ² PTPRQ² PTPN18²

PTPN12² PTPN5² PTPRB² PTPRR²

18/19 SIMAP similar genes for PTPN11 using alignment to 6 protein entries: PTN11_HUMAN (see all proteins) (see all similar genes):

PTPN6 GRB2 NCK1 GRAP2 VAV3 SHF

RASA1 CLNK CSK VAV1 PIK3R3 SH2B2

HCK SHC4 MATK FYN LCK SYK

PTPN11 for paralogs About GeneDecksing

5/6 Pseudogenes.org Pseudogenes for PTPN11 (see all 6)
PGOHUM00000244574 PGOHUM00000237709 PGOHUM00000245615 PGOHUM00000235162 PGOHUM00000243393

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28933386^1,2	C	pathogenic	112915523(+)	`ATGCAA/GATATC`	4	N D	mis¹		1		NA	4550
rs121918457^1,2	C	pathogenic	112926270(+)	`AGGGAC/TGTTCA`	2	T M	mis¹		1		EU	1323
rs121918470^1,2	C	pathogenic	112926909(+)	`AGCACA/C/GGTACC`	3	Q P R	mis¹		0	--	--	--	--
rs61736914^1,2	C,F	probable-non-pathogenic	112888239(+)	`CATCAC/TGGGCA`	4	H	syn¹		4		NS WA NA	4740
rs184804143^1,2	C	unknown	112892360(+)	`TTTATA/CTTGAA`	2	--	int¹		0	--	--	--	--
rs121918465^1,2	C	other	112888211(+)	`GGCTGA/C/G/T GTTGG`	8	E A G V	mis¹		0	--	--	--	--
rs7315529^1,2	C,F,H	--	112854795(+)	`AAAAAA/GTGAGG`	2	--	us2k¹ tfbs³		3		NS NA	408
rs144639620^1,2		--	112855011(+)	`TGTGCA/GCCACC`	2	--	us2k¹		0	--	--	--	--
rs112454444^1,2	C,F	--	112855348(+)	`CTTCCG/CTACCA`	2	--	us2k¹		3		WA CSA	122
rs12316606^1,2	H	--	112855395(+)	`tttaaG/Aagaca`	2	--	us2k¹		4		NS EA	410
rs148477998^1,2		--	112855593(+)	`AGTAGC/GTGGGA`	2	--	us2k¹		0	--	--	--	--
rs142638276^1,2		--	112855596(+)	`AGCTGA/GGACTA`	2	--	us2k¹		0	--	--	--	--
rs34348583^1,2	F	--	112855625(+)	`CCCGGC/GTAATT`	2	--	us2k¹		1		NA	6
rs199659493^1,2		--	112855785(+)	`TTGTA-/ATTATT ATTAT`	2	--	us2k¹		0	--	--	--	--
rs147193211^1,2		--	112855815(+)	`AGTCTC/TGCTCT`	2	--	us2k¹		0	--	--	--	--
rs192084767^1,2		--	112855868(+)	`AACCTA/CTGCCT`	2	--	us2k¹		0	--	--	--	--
rs113381499^1,2	C	--	112855886(+)	`TCAAGC/AGATTC`	2	--	us2k¹		1		WA	2
rs147686007^1,2		--	112855920(+)	`CTGGGA/TCTACA`	2	--	us2k¹		0	--	--	--	--
rs139705983^1,2		--	112856135(+)	`TGCAGA/TGGCGT`	2	--	us2k¹		0	--	--	--	--
rs116434828^1,2		--	112856405(+)	`ACAGTA/GGGTAA`	2	--	us2k¹		0	--	--	--	--
rs58805176^1,2	C	--	112856643(+)	`CTGACG/AGGAAG`	2	--	ut5¹		4		NA WA EA	360
rs149766959^1,2		--	112856736(+)	`GGGCCA/GGGGGG`	2	--	ut5¹		0	--	--	--	--
rs7972574^1,2	C,A	--	112856954(+)	`CCGGCG/CCGGGC`	2	--	int¹		1		WA	2
rs7973432^1,2	C	--	112856983(+)	`GCGTTC/AGGTTA`	2	--	int¹		1		WA	2
rs145853010^1,2		--	112857584(+)	`TTAATC/TCTTCA`	2	--	int¹		0	--	--	--	--
rs146610066^1,2		--	112857640(+)	`GATGAA/GGAAAC`	2	--	int¹		0	--	--	--	--
rs141333539^1,2		--	112857662(+)	`AGCAAC/TATGCT`	2	--	int¹		0	--	--	--	--
rs182758581^1,2		--	112858000(+)	`TGATCC/TTGCTA`	2	--	int¹		0	--	--	--	--
rs187514399^1,2		--	112858054(+)	`TGTCTA/GTTCTT`	2	--	int¹		0	--	--	--	--
rs144698980^1,2		--	112858294(+)	`ACAGGC/TGCACC`	2	--	int¹		0	--	--	--	--
rs148214606^1,2		--	112858348(+)	`TCACTA/GTGTTG`	2	--	int¹		0	--	--	--	--
rs191351165^1,2		--	112858531(+)	`AAAAGA/GGGAGA`	2	--	int¹		0	--	--	--	--
rs182396304^1,2		--	112858897(+)	`AAAGAC/TGACAG`	2	--	int¹		0	--	--	--	--
rs187031945^1,2		--	112859818(+)	`TATTGC/GTATTT`	2	--	int¹		0	--	--	--	--
rs192083826^1,2		--	112859993(+)	`GACAAC/TTAGTA`	2	--	int¹		0	--	--	--	--
rs185332307^1,2		--	112860091(+)	`TCAATA/GTACTG`	2	--	int¹		0	--	--	--	--
rs16942050^1,2	C,F,H	--	112860113(+)	`CATCAT/CAGGTA`	2	--	int¹		20		NA NS EA WA CSA	2280
rs190546934^1,2		--	112860316(+)	`CCATAC/TGCGAC`	2	--	int¹		0	--	--	--	--
rs141168964^1,2		--	112860429(+)	`GCCACA/GTTTGT`	2	--	int¹		0	--	--	--	--
rs150295091^1,2		--	112860607(+)	`GTGTCC/TATGGT`	2	--	int¹		0	--	--	--	--
rs116195835^1,2	C	--	112860794(+)	`ATGTTC/TTTAAG`	2	--	int¹		0	--	--	--	--
rs115302115^1,2	C,F	--	112860916(+)	`TTACTA/GTGAAT`	2	--	int¹		1		WA	118
rs143737920^1,2		--	112861066(+)	`ATTTGA/GTAAAG`	2	--	int¹		0	--	--	--	--
rs147209593^1,2		--	112861424(+)	`ACTGTA/TTAGAA`	2	--	int¹		0	--	--	--	--
rs193045724^1,2		--	112861445(+)	`TATATA/GTATAT`	2	--	int¹		0	--	--	--	--
rs140529519^1,2		--	112861455(+)	`TTTGTA/GTACTC`	2	--	int¹		0	--	--	--	--
rs114903501^1,2	F	--	112861609(+)	`GCAGTG/AGCATA`	2	--	int¹		1		WA	118
rs74670976^1,2	F	--	112861702(+)	`GGCACG/CTGGCA`	2	--	int¹		1		WA	118
rs76279965^1,2		--	112861902(+)	`CATCCC/TACTGG`	2	--	int¹		1		WA	118
rs142793492^1,2		--	112862039(+)	`AGTGGG/TAGAAG`	2	--	int¹		0	--	--	--	--
rs185745872^1,2		--	112862341(+)	`TTTGAA/GCTTGG`	2	--	int¹		0	--	--	--	--
rs188117272^1,2		--	112862576(+)	`CTCAGC/TTCACT`	2	--	int¹		0	--	--	--	--
rs180885206^1,2		--	112862659(+)	`CCACCA/GTGTCA`	2	--	int¹		0	--	--	--	--
rs7955111^1,2	C,A	--	112862695(+)	`tgtgtA/Gtgtgt`	2	--	int¹		0	--	--	--	--
rs140408920^1,2	C	--	112862747(+)	`ACCAC-/CATGTCAG`	2	--	int¹		0	--	--	--	--
rs34463047^1,2	C	--	112862762(+)	`TAATT-/GTGTGTG`	2	--	int¹		1		NA	2
rs185679073^1,2		--	112862938(+)	`CAGACG/TTGAGC`	2	--	int¹		0	--	--	--	--
rs148740580^1,2		--	112862951(+)	`CTGTGC/TCCACC`	2	--	int¹		0	--	--	--	--
rs74644204^1,2	C,F	--	112862991(+)	`GTAGGA/TTATTT`	2	--	int¹		1		NA	120
rs142297193^1,2		--	112863151(+)	`TCCCTA/GTTGAT`	2	--	int¹		0	--	--	--	--
rs188826184^1,2		--	112863494(+)	`CCCCTC/GCCACC`	2	--	int¹		0	--	--	--	--
rs11066291^1,2	C,F,A,H	--	112863559(+)	`ACAAGG/ATCTCA`	2	--	int¹		13		EA NS WA	1814
rs181551858^1,2		--	112863590(+)	`GGCAAC/TGTTGC`	2	--	int¹		0	--	--	--	--
rs10129047^1,2	C,F,H	--	112864028(+)	`CGGGTG/ATGATT`	2	--	int¹		18		NS EA NA WA CSA	2162
rs10129049^1,2	C	--	112864102(+)	`gtagcG/Acaggc`	2	--	int¹		4		NA WA	124
rs139233208^1,2		--	112864316(+)	`TCAGCC/TTCCCA`	2	--	int¹		0	--	--	--	--
rs186901321^1,2		--	112864356(+)	`GCAGCC/TGGCCA`	2	--	int¹		0	--	--	--	--
rs144526480^1,2		--	112864402(+)	`AATGTA/TAACTC`	2	--	int¹		0	--	--	--	--
rs191973553^1,2		--	112864425(+)	`ATTATC/GTCTCC`	2	--	int¹		0	--	--	--	--
rs183713623^1,2		--	112864489(+)	`TATTTA/TAGACA`	2	--	int¹		0	--	--	--	--
rs187431936^1,2		--	112864494(+)	`TAGACA/GTTGAT`	2	--	int¹		0	--	--	--	--
rs146628426^1,2		--	112864865(+)	`GTAACA/GTGGGT`	2	--	int¹		0	--	--	--	--
rs11066292^1,2		--	112865005(+)	`AGATCA/GTGTCT`	2	--	int¹		0	--	--	--	--
rs189537930^1,2		--	112865298(+)	`TGAGCC/TGAGAC`	2	--	int¹		0	--	--	--	--
rs182354423^1,2		--	112865563(+)	`TTTATG/TTATTT`	2	--	int¹		0	--	--	--	--
rs11066294^1,2	C	--	112865578(+)	`TGAGAA/CAAGGT`	2	--	int¹		2		WA EA	122
rs186974710^1,2		--	112865631(+)	`GCTCAC/TTGAAG`	2	--	int¹		0	--	--	--	--
rs118172404^1,2	F	--	112865692(+)	`TGGGAC/TCACAG`	2	--	int¹		1		EA	120
rs190212875^1,2		--	112865702(+)	`GGTGCA/GTACAA`	2	--	int¹		0	--	--	--	--
rs183354985^1,2		--	112865759(+)	`TATGCC/TGTCCA`	2	--	int¹		0	--	--	--	--
rs76044374^1,2	C,F	--	112865800(+)	`TTCTCT/CTGCCT`	2	--	int¹		9		WA NA CSA EA	371
rs188233411^1,2		--	112865822(+)	`AGTGCC/TGGCAT`	2	--	int¹		0	--	--	--	--
rs73425482^1,2	C,F	--	112865833(+)	`TATGGG/ACATAA`	2	--	int¹		4		WA CSA NA	242
rs145100719^1,2		--	112866060(+)	`CATACC/TGTTTT`	2	--	int¹		0	--	--	--	--
rs193163157^1,2		--	112866077(+)	`TCCCCG/TCCTTC`	2	--	int¹		0	--	--	--	--
rs11312766^1,2	C	--	112866201(+)	`TTGTCT/-TTTTT`	2	--	int¹ trp³		2		NA	4
rs145534969^1,2		--	112866331(+)	`AGGGTC/GGAATG`	2	--	int¹		0	--	--	--	--
rs79532022^1,2	C	--	112866456(+)	`TTTGGA/GAAAAA`	2	--	int¹		0	--	--	--	--
rs185369027^1,2		--	112866573(+)	`TGAGAC/TGGAGT`	2	--	int¹		0	--	--	--	--
rs188065245^1,2		--	112866794(+)	`GATCCA/GCCTGC`	2	--	int¹		0	--	--	--	--
rs143476093^1,2		--	112866831(+)	`CAGGCA/GTGAGC`	2	--	int¹		0	--	--	--	--
rs61941346^1,2	C	--	112866929(+)	`CTTAAA/GTGACA`	2	--	int¹		2		NA	122
rs191383880^1,2		--	112867172(+)	`ATAATA/CCAGTT`	2	--	int¹		0	--	--	--	--
rs7398235^1,2	C,H	--	112867356(+)	`ATCCCA/CGCACT`	2	--	int¹		6		NA WA CSA	11
rs6489843^1,2	C,H	--	112867379(+)	`GGCGGG/ACAGAT`	2	--	int¹		4		NA WA CSA	7
rs188599111^1,2		--	112867477(+)	`GTGGTA/GCACAC`	2	--	int¹		0	--	--	--	--
rs181184051^1,2		--	112867599(+)	`AGGACC/TCCGTC`	2	--	int¹		0	--	--	--	--
rs184957251^1,2		--	112867755(+)	`GGCATA/GTGGCA`	2	--	int¹		0	--	--	--	--
rs143390095^1,2		--	112867819(+)	`ACATAA/TCACAT`	2	--	int¹		0	--	--	--	--
rs146217634^1,2		--	112867918(+)	`CTCCTG/TAGTTC`	2	--	int¹		0	--	--	--	--
rs189838972^1,2		--	112868079(+)	`GAGATG/TACAGG`	2	--	int¹		0	--	--	--	--
rs181935332^1,2		--	112868196(+)	`CTTTTA/TAATTT`	2	--	int¹		0	--	--	--	--
rs186244852^1,2		--	112868298(+)	`CACAAC/TCATGG`	2	--	int¹		0	--	--	--	--
rs191053015^1,2		--	112868311(+)	`CACTGC/TAGCCT`	2	--	int¹		0	--	--	--	--
rs115115979^1,2	F	--	112868429(+)	`TAGAGA/GTGAGG`	2	--	int¹		1		WA	118
rs180785627^1,2		--	112868442(+)	`TCACTA/GTGTTG`	2	--	int¹		0	--	--	--	--
rs184964636^1,2		--	112868633(+)	`TGCACA/GGGGAG`	2	--	int¹		0	--	--	--	--
rs11066296^1,2	C,F,H	--	112868680(+)	`TCCTAG/AACATT`	2	--	int¹		9		NS EA NA	1054
rs189767853^1,2		--	112868764(+)	`ATTGGG/TTGAGA`	2	--	int¹		0	--	--	--	--
rs182806247^1,2		--	112868779(+)	`ACTGTA/GTATTA`	2	--	int¹		0	--	--	--	--
rs28579210^1,2	C,F,H	--	112868826(+)	`GTGGGG/TCCAGT`	2	--	int¹		6		NS NA WA	784
rs59787000^1,2	C	--	112868879(+)	`AGTACG/ATGGAG`	2	--	int¹		3		WA CSA	121
rs138909068^1,2		--	112868882(+)	`ACGTGA/GAGTTG`	2	--	int¹		0	--	--	--	--
rs191555692^1,2		--	112869069(+)	`GTGGTA/GAAGAA`	2	--	int¹		0	--	--	--	--
rs73209627^1,2	C,F	--	112869092(+)	`CTACTC/TGGGAT`	2	--	int¹		1		NA	120
rs115273032^1,2	C,F	--	112869555(+)	`AACTCC/TAAGGG`	2	--	int¹		1		WA	118
rs183816634^1,2		--	112869565(+)	`GCGTTC/GTGTGC`	2	--	int¹		0	--	--	--	--
rs142829342^1,2		--	112869573(+)	`TGCTAA/GACATT`	2	--	int¹		0	--	--	--	--
rs150770275^1,2		--	112869617(+)	`TTGCTG/TTGAAT`	2	--	int¹		0	--	--	--	--
rs201725245^1,2	C	--	112869736(+)	`AAAAA-/GGGGGG`	2	--	int¹		0	--	--	--	--
rs75326242^1,2	C,F	--	112869780(+)	`CAGTAA/GAGGGT`	2	--	int¹		1		NA	120
rs11066297^1,2	C,F,H	--	112869855(+)	`GTTTGA/C/G/T CGTTG`	2	--	int¹		9		NS NA WA	1178
rs187825668^1,2		--	112869891(+)	`AAGTGA/GTCTGA`	2	--	int¹		0	--	--	--	--
rs139121229^1,2		--	112869902(+)	`AAACAC/TGAAAA`	2	--	int¹		0	--	--	--	--
rs12578901^1,2	C,H	--	112870008(+)	`ttggcA/Gcaagt`	2	--	int¹		2		NA	4
rs192611630^1,2		--	112870020(+)	`AGGGAA/CAACAG`	2	--	int¹		0	--	--	--	--
rs185005358^1,2		--	112870047(+)	`TGCCCA/GTCCAA`	2	--	int¹		0	--	--	--	--
rs186668916^1,2		--	112870203(+)	`AGTGGC/GTCTCA`	2	--	int¹		0	--	--	--	--
rs149380154^1,2		--	112870222(+)	`CCCAGC/TACTTT`	2	--	int¹		0	--	--	--	--
rs144715252^1,2		--	112870319(+)	`ATACAA/GACAAT`	2	--	int¹		0	--	--	--	--
rs192739859^1,2		--	112870617(+)	`CATCTA/CAAAAA`	2	--	int¹		0	--	--	--	--
rs200098164^1,2		--	112870668(+)	`TTTAA-/CCTTTT`	2	--	int¹		0	--	--	--	--
rs117399332^1,2	C	--	112870670(+)	`TTAACC/TTTTTT`	2	--	int¹		0	--	--	--	--
rs190033809^1,2		--	112870697(+)	`TCTTGC/GTGTGT`	2	--	int¹		0	--	--	--	--
rs181699192^1,2		--	112870898(+)	`GACCTC/TAAGTG`	2	--	int¹		0	--	--	--	--
rs184462298^1,2		--	112870912(+)	`CGCCTA/GCCTCA`	2	--	int¹		0	--	--	--	--
rs74540768^1,2		--	112871176(+)	`AAGTAC/GGCTCC`	2	--	int¹		0	--	--	--	--
rs144192256^1,2		--	112871342(+)	`AAAGGA/GTATGT`	2	--	int¹		0	--	--	--	--
rs11066301^1,2	C,F,A,H	--	112871372(+)	`TAACAA/GAAAAC`	2	--	int¹		16		NS EA NA	1620
rs117162013^1,2	C,F	--	112871486(+)	`GCAGTG/TGNNNN`	2	--	int¹		1		NA	120
rs189020075^1,2		--	112871584(+)	`ACCCTA/GTCTCT`	2	--	int¹		0	--	--	--	--
rs146163336^1,2		--	112871635(+)	`ACACCC/TTCATG`	2	--	int¹		0	--	--	--	--
rs181769262^1,2		--	112871715(+)	`CATGAC/TTGTGC`	2	--	int¹		0	--	--	--	--
rs186297901^1,2		--	112872092(+)	`AAACAA/GCAACC`	2	--	int¹		0	--	--	--	--
rs116568846^1,2	C,F	--	112872521(+)	`AGGCTC/TAGAGG`	2	--	int¹		1		WA	118
rs190596079^1,2		--	112872555(+)	`ACATAA/C/TGTGTC`	2	--	int¹		0	--	--	--	--
rs181065966^1,2		--	112872556(+)	`CATACA/GTGTCA`	2	--	int¹		0	--	--	--	--
rs186307568^1,2		--	112872732(+)	`ACTACA/GGGCAC`	2	--	int¹		0	--	--	--	--
rs140177034^1,2		--	112872975(+)	`GTGCCA/GTCAAT`	2	--	int¹		0	--	--	--	--
rs143849108^1,2		--	112872987(+)	`CCCCAC/TCAATT`	2	--	int¹		0	--	--	--	--
rs151301431^1,2		--	112873223(+)	`AGAATC/TTATTT`	2	--	int¹		0	--	--	--	--
rs140532343^1,2		--	112873226(+)	`ATCTAC/TTTTAA`	2	--	int¹		0	--	--	--	--
rs191552559^1,2		--	112873242(+)	`GAAGAA/GATGAC`	2	--	int¹		0	--	--	--	--
rs11462761^1,2	C	--	112873452(+)	`TTTTT-/TAAATA`	2	--	int¹ trp³		0	--	--	--	--
rs115995284^1,2		--	112873582(+)	`GCAAAA/GGACAG`	2	--	int¹		1		WA	118
rs182948818^1,2		--	112873677(+)	`TGGCTA/GAGCCA`	2	--	int¹		0	--	--	--	--
rs11066304^1,2	H	--	112873848(+)	`AAAAAA/GGAAAA`	2	--	int¹ trp³		4		NS EA	418
rs11066305^1,2	H	--	112873849(+)	`aaaaaG/Aaaaaa`	2	--	int¹ trp³		4		NS EA	412
rs149910248^1,2		--	112873852(+)	`AAGAAA/GAAAAA`	2	--	int¹		0	--	--	--	--
rs73209628^1,2	C,F	--	112874018(+)	`GTAATT/GGCATA`	2	--	int¹		2		NA EA	240
rs75098304^1,2	C	--	112874179(+)	`TTCCTA/GTGAGG`	2	--	int¹		2		NA	122
rs151156812^1,2		--	112874205(+)	`CCACA-/TTTTTA`	2	--	int¹		0	--	--	--	--
rs185992266^1,2		--	112874211(+)	`TTTTAC/GAGATG`	2	--	int¹		0	--	--	--	--
rs190704790^1,2		--	112874252(+)	`TGCCCA/GGGAGA`	2	--	int¹		0	--	--	--	--
rs144935652^1,2		--	112874305(+)	`TTGCTA/TCAATA`	2	--	int¹		0	--	--	--	--
rs141995573^1,2		--	112874595(+)	`TGGAGC/TTGAAT`	2	--	int¹		0	--	--	--	--
rs183256053^1,2		--	112874648(+)	`TCAAAC/TTGCAA`	2	--	int¹		0	--	--	--	--
rs145755092^1,2		--	112874741(+)	`AAAATA/GGTAAT`	2	--	int¹		0	--	--	--	--
rs187916423^1,2		--	112874881(+)	`CCTTAC/TTCTAA`	2	--	int¹		0	--	--	--	--
rs75924654^1,2	C,F	--	112874889(+)	`TAAGGT/GTAACA`	2	--	int¹		1		WA	118
rs192304804^1,2		--	112874893(+)	`GTTAAC/TAAGAC`	2	--	int¹		0	--	--	--	--
rs138976219^1,2		--	112875014(+)	`CAGTGA/GAATGA`	2	--	int¹		0	--	--	--	--
rs141439718^1,2		--	112875185(+)	`GTCTCA/GAACTC`	2	--	int¹		0	--	--	--	--
rs183012559^1,2		--	112875193(+)	`CTCCTA/GACCTT`	2	--	int¹		0	--	--	--	--
rs187923910^1,2		--	112875390(+)	`CATGAA/GTACCA`	2	--	int¹		0	--	--	--	--
rs143581258^1,2		--	112875530(+)	`ATTTGA/GTCTTT`	2	--	int¹		0	--	--	--	--
rs148038743^1,2		--	112875583(+)	`TGATTC/TTCTGT`	2	--	int¹		0	--	--	--	--
rs192970226^1,2		--	112875590(+)	`CTGTGC/TGGTAG`	2	--	int¹		0	--	--	--	--
rs141721981^1,2		--	112875692(+)	`ATACAA/GGTTGG`	2	--	int¹		0	--	--	--	--
rs184039429^1,2		--	112875720(+)	`ACTCTA/GATGGG`	2	--	int¹		0	--	--	--	--
rs150859544^1,2		--	112875763(+)	`TTACAC/TGTTTG`	2	--	int¹		0	--	--	--	--
rs188776106^1,2		--	112875910(+)	`TAGAGC/TAATTT`	2	--	int¹		0	--	--	--	--
rs192106250^1,2		--	112875922(+)	`AGGCCC/TGCCAC`	2	--	int¹		0	--	--	--	--
rs184693946^1,2		--	112876199(+)	`CATAGC/TTTACT`	2	--	int¹		0	--	--	--	--
rs190786024^1,2		--	112876381(+)	`CCCGGA/GTTCAA`	2	--	int¹		0	--	--	--	--
rs138302899^1,2		--	112876419(+)	`TAGCTC/GAGACT`	2	--	int¹		0	--	--	--	--
rs113018249^1,2		--	112876596(+)	`GCTAAC/TTTTTA`	2	--	int¹		2		CSA	3
rs146059469^1,2		--	112876654(+)	`GAACAA/CCTGGC`	2	--	int¹		0	--	--	--	--
rs78401045^1,2	C	--	112876732(+)	`TTTTG-/TTTTTT`	2	--	int¹		0	--	--	--	--
rs79256372^1,2		--	112876754(+)	`TGTTGT/CTTTTG`	2	--	int¹		1		WA	118
rs140000879^1,2		--	112876922(+)	`TTAACA/GGAGAG`	2	--	int¹		0	--	--	--	--
rs12296808^1,2	C,F,H	--	112877019(+)	`TTTGCC/TACCAT`	2	--	int¹		15		NS NA WA CSA	1934
rs79459008^1,2	C,F	--	112877047(+)	`CCTGTC/AATTTG`	2	--	int¹		1		WA	118
rs116155570^1,2	F	--	112877304(+)	`GTCTCG/ACTCTT`	2	--	int¹		1		WA	118
rs79065330^1,2		--	112877589(+)	`TTTTTA/TAAAAA`	2	--	int¹		0	--	--	--	--
rs200945931^1,2		--	112877595(+)	`AAAAA-/CAAAAC`	2	--	int¹		0	--	--	--	--
rs1966343^1,2	C,F,A,H	--	112877600(-)	`TTTTTT/GTTTTT`	2	--	int¹		3		NA WA	6
rs201900443^1,2		--	112877600(+)	`AAAAA-/CAAAAA`	2	--	int¹		0	--	--	--	--
rs180809958^1,2	C	--	112877606(+)	`NNNNAA/CAAAAA`	2	--	int¹		0	--	--	--	--
rs180800428^1,2		--	112877612(+)	`AAAAAA/CAAAAA`	2	--	int¹		0	--	--	--	--
rs186189475^1,2		--	112877689(+)	`TTTCCA/GTTTTT`	2	--	int¹		0	--	--	--	--
rs11066306^1,2	C,F,H	--	112877906(+)	`CCTTAG/AAATTC`	2	--	int¹		11		NS EA NA	1384
rs111540920^1,2	C	--	112878056(+)	`TTTCCC/TGGGTG`	2	--	int¹		1		NA	2
rs189267580^1,2		--	112878202(+)	`CCTCCC/TGAGTA`	2	--	int¹		0	--	--	--	--
rs7961064^1,2	C,F,A,H	--	112878426(+)	`aggctG/Agagcg`	2	--	int¹		4		EA NS WA	284
rs7296254^1,2	C	--	112878502(+)	`cctccC/Ggagta`	2	--	int¹		0	--	--	--	--
rs12313328^1,2	H	--	112878513(+)	`tctgaG/Aattac`	2	--	int¹		4		NS EA	402
rs142058544^1,2		--	112878724(+)	`ATGAAA/TATTTC`	2	--	int¹		0	--	--	--	--
rs200029372^1,2		--	112878773(+)	`CTTTT-/CTTTTT`	2	--	int¹		0	--	--	--	--
rs114906931^1,2	F	--	112878811(+)	`TGCCCA/GGGCTA`	2	--	int¹		1		WA	118
rs144255079^1,2		--	112878917(+)	`GCATGC/GGCCAC`	2	--	int¹		0	--	--	--	--
rs147773551^1,2		--	112879189(+)	`GCCTCA/CTGAGT`	2	--	int¹		0	--	--	--	--
rs141090203^1,2		--	112879872(+)	`CACCGC/TGCCTG`	2	--	int¹		0	--	--	--	--
rs185749820^1,2		--	112879899(+)	`TGCTGC/GTAACT`	2	--	int¹		0	--	--	--	--
rs12309312^1,2	C,F	--	112879955(+)	`CATTTA/GTGGGt`	2	--	int¹		3		WA CSA	122
rs61941348^1,2	F	--	112880119(+)	`TTGGAT/CTTCAG`	2	--	int¹		1		NA	120
rs141995765^1,2		--	112880438(+)	`TTTAG-/TAGAGA`	2	--	int¹		0	--	--	--	--
rs12304009^1,2	C	--	112880508(+)	`gcctcC/Tgcctc`	2	--	int¹		1		WA	2
rs73425490^1,2	C	--	112880579(+)	`TAGATT/CTGGGA`	2	--	int¹		2		WA	120
rs12425403^1,2	C,H	--	112880681(+)	`atataA/Taaatt`	2	--	int¹		0	--	--	--	--
rs148864887^1,2		--	112880706(+)	`ATATA-/TGT ATGTATTGTAT`	2	--	int¹		0	--	--	--	--
rs11282974^1,2	C	--	112880715(+)	`TGTAT-/TGT ATGTATATGTA`	2	--	int¹		0	--	--	--	--
rs183198616^1,2		--	112880830(+)	`GGGTAA/GGTTGC`	2	--	int¹		0	--	--	--	--
rs187153485^1,2		--	112880921(+)	`TATCAA/CCAAAT`	2	--	int¹		0	--	--	--	--
rs192449140^1,2		--	112880923(+)	`TCACCA/GAATGT`	2	--	int¹		0	--	--	--	--
rs182488474^1,2		--	112881118(+)	`TAATTA/GGGATA`	2	--	int¹		0	--	--	--	--
rs138076567^1,2		--	112881204(+)	`GTTGCC/TCAGGC`	2	--	int¹		0	--	--	--	--
rs149095418^1,2		--	112881255(+)	`TCTCCC/TGGGTT`	2	--	int¹		0	--	--	--	--
rs12582819^1,2	C,F,H	--	112881309(+)	`AGGCCT/CGCGCC`	2	--	int¹		8		NA WA EA	368
rs143126933^1,2		--	112881322(+)	`CTTGCC/TCAGCT`	2	--	int¹		0	--	--	--	--
rs1966342^1,2	C,F,A,H	--	112881342(+)	`ATTTTA/GTGAGA`	2	--	int¹		11		NA WA CSA EA	378
rs12299569^1,2		--	112881380(+)	`gtctcA/Gaactc`	2	--	int¹		0	--	--	--	--
rs192353035^1,2		--	112881401(+)	`GATCCA/GCCCGC`	2	--	int¹		0	--	--	--	--
rs138369352^1,2		--	112881519(+)	`TGGTAC/TGATCT`	2	--	int¹		0	--	--	--	--
rs142856550^1,2		--	112881559(+)	`TCAGGC/TGATCC`	2	--	int¹		0	--	--	--	--
rs113378566^1,2	C	--	112881873(+)	`TATAGG/CCGTGA`	2	--	int¹		2		WA	120
rs182375018^1,2		--	112881911(+)	`TTCAAC/TCTCAG`	2	--	int¹		0	--	--	--	--
rs187182327^1,2		--	112881923(+)	`GGAGCA/GGCATT`	2	--	int¹		0	--	--	--	--
rs138824211^1,2		--	112881932(+)	`TTCAAA/GCTATA`	2	--	int¹		0	--	--	--	--
rs141402837^1,2		--	112881944(+)	`CATTGC/TCCTTT`	2	--	int¹		0	--	--	--	--
rs150913938^1,2		--	112881949(+)	`TCCTTG/TAGTGA`	2	--	int¹		0	--	--	--	--
rs11066308^1,2	C,F,A,H	--	112881996(+)	`CATCTA/GTAGAC`	2	--	int¹		20		NS EA NA WA	2350
rs139405273^1,2		--	112882294(+)	`GCACGC/TGCCAC`	2	--	int¹		0	--	--	--	--
rs192042875^1,2		--	112882372(+)	`CTCCCA/GACCTC`	2	--	int¹		0	--	--	--	--
rs74374761^1,2	F	--	112882483(+)	`AAAAAA/TTAGGA`	2	--	int¹		1		WA	118
rs143557201^1,2		--	112882846(+)	`GGAAA-/TGTGTGT`	2	--	int¹		0	--	--	--	--
rs7977554^1,2	C,F,A	--	112882859(+)	`TGTGTG/ATATAT`	2	--	int¹		3		WA EA	124
rs184447201^1,2		--	112883004(+)	`GATCAC/TGGCTC`	2	--	int¹		0	--	--	--	--
rs149626041^1,2		--	112883066(+)	`GAGTAA/GCTGGG`	2	--	int¹		0	--	--	--	--
rs190291557^1,2		--	112883143(+)	`ATTGGC/GCAGGA`	2	--	int¹		0	--	--	--	--
rs147299317^1,2		--	112883187(+)	`CGCCTC/TGGCCT`	2	--	int¹		0	--	--	--	--
rs140875911^1,2		--	112883246(+)	`CATACA/GTATCT`	2	--	int¹		0	--	--	--	--
rs116260404^1,2	C,F	--	112883260(+)	`TCTATA/GTCTAC`	2	--	int¹		1		WA	118
rs186130452^1,2	C	--	112883443(+)	`TTATTC/TTTTTT`	2	--	int¹		0	--	--	--	--
rs10774652^1,2	C,F,H	--	112883468(+)	`GAGATG/TGAGTT`	2	--	int¹		11		NS EA NA WA CSA	431
rs11066309^1,2	C,F,A	--	112883476(+)	`GTTTCG/ACTCTT`	2	--	int¹		4		NA	8
rs139487796^1,2		--	112883660(+)	`GCTGCC/TCTGGA`	2	--	int¹		0	--	--	--	--
rs142504170^1,2		--	112883675(+)	`CCGACC/TCCAGC`	2	--	int¹		0	--	--	--	--
rs17849093^1,2	C	--	112883878(+)	`CCCCTA/GCTGAA`	2	--	int¹		0	--	--	--	--
rs140881453^1,2		--	112883906(+)	`GGGAAA/GGGCAG`	2	--	int¹		0	--	--	--	--
rs193223773^1,2		--	112883949(+)	`AGGGAC/GAGGGA`	2	--	int¹		0	--	--	--	--
rs150154839^1,2		--	112884028(+)	`AAAGTA/CGTGCT`	2	--	int¹		0	--	--	--	--
rs79203122^1,2	C	--	112884083(+)	`AGATGG/TTTTCA`	4	W C	mis¹		0	--	--	--	--
rs200613531^1,2	C	--	112884094(+)	`CCCAAA/GTATCA`	4	N S	mis¹		0	--	--	--	--
rs146729113^1,2		--	112884716(+)	`CCAGGC/TTGGAG`	2	--	int¹		0	--	--	--	--
rs57213771^1,2	C	--	112884996(+)	`AGAAAA/GATACT`	2	--	int¹		2		WA	120
rs78985380^1,2	C	--	112885153(+)	`CTGAAC/TGTGTT`	2	--	int¹		1		EA	120
rs77342137^1,2	C	--	112885267(+)	`AACTTA/GAAAAT`	2	--	int¹		2		WA	120
rs185624523^1,2		--	112885364(+)	`AATGGC/TGTGAT`	2	--	int¹		0	--	--	--	--
rs11066310^1,2		--	112885509(+)	`ATGTCA/GACCAG`	2	--	int¹		0	--	--	--	--
rs145069008^1,2		--	112885552(+)	`GCCTGC/TCTTGG`	2	--	int¹		0	--	--	--	--
rs138857900^1,2		--	112885556(+)	`GCCTTC/GGCCTC`	2	--	int¹		0	--	--	--	--
rs149361318^1,2		--	112885924(+)	`TCTTAC/GTCCTA`	2	--	int¹		0	--	--	--	--
rs189302362^1,2		--	112885951(+)	`CTCCAG/TTCTGT`	2	--	int¹		0	--	--	--	--
rs180902705^1,2		--	112886268(+)	`TGCCTA/GTCTCA`	2	--	int¹		0	--	--	--	--
rs143652554^1,2		--	112886850(+)	`CACGCC/TCAGCT`	2	--	int¹		0	--	--	--	--
rs185700918^1,2		--	112886910(+)	`GGTATC/TGGTCT`	2	--	int¹		0	--	--	--	--
rs188838656^1,2		--	112886935(+)	`ATCCTC/TCCACC`	2	--	int¹		0	--	--	--	--
rs200333899^1,2		--	112886995(+)	`ATCAC-/TTTTTT`	2	--	int¹		0	--	--	--	--
rs73425495^1,2	C	--	112887008(+)	`TTTTTT/CTTAAT`	2	--	int¹		3		WA NA CSA	5
rs201757045^1,2		--	112887008(+)	`TTTTT-/CTTAAT`	2	--	int¹		0	--	--	--	--
rs113379664^1,2		--	112887044(+)	`GCTCAT/CGCCTG`	2	--	int¹		1		CSA	1
rs181547804^1,2		--	112887081(+)	`GCAGGC/TGGCGG`	2	--	int¹		0	--	--	--	--
rs142012941^1,2		--	112887175(+)	`GCGTCA/GTGGCG`	2	--	int¹		0	--	--	--	--
rs199519175^1,2		--	112887302(+)	`TGAGA-/CTCTGTC`	2	--	int¹		0	--	--	--	--
rs187093660^1,2		--	112887332(+)	`ACAAAA/CAAATT`	2	--	int¹		0	--	--	--	--
rs191682841^1,2		--	112887514(+)	`TTGGTA/GGCTAT`	2	--	int¹		0	--	--	--	--
rs182224722^1,2		--	112887584(+)	`TACAAG/TGTAGG`	2	--	int¹		0	--	--	--	--
rs147316199^1,2		--	112887607(+)	`GCTCAC/TGCCTG`	2	--	int¹		0	--	--	--	--
rs140944701^1,2		--	112887722(+)	`AAAGTA/GGCTGA`	2	--	int¹		0	--	--	--	--
rs112250652^1,2		--	112887729(+)	`CTGAGC/TGTGGT`	2	--	int¹		2		CSA WA	120
rs187188032^1,2		--	112887794(+)	`AACCTA/GGATTT`	2	--	int¹		0	--	--	--	--
rs114299948^1,2	F	--	112887808(+)	`ATGTAT/CGTAAA`	2	--	int¹		1		WA	118
rs189699675^1,2		--	112887820(+)	`CCACCA/GCGAAG`	2	--	int¹		0	--	--	--	--
rs7976467^1,2	C,F,A,H	--	112887941(+)	`CCTTTG/CTGTTG`	2	--	int¹		21		NS EA NA WA CSA	2448
rs143189981^1,2		--	112888041(+)	`AAATCC/TGACGT`	2	--	int¹		0	--	--	--	--
rs16942067^1,2	C,F,H	--	112888042(+)	`AATCCG/AACGTG`	2	--	int¹		7		NA NS WA	870
rs182335523^1,2		--	112888045(+)	`CCGACA/GTGGAA`	2	--	int¹		0	--	--	--	--
rs147388185^1,2	C	--	112888140(+)	`GTCACC/TCACAT`	4	T	syn¹		0	--	--	--	--
rs115658366^1,2	C	--	112888333(+)	`TTTAGT/GGACCA`	2	--	int¹		2		WA EU	1441
rs186941126^1,2	C	--	112888351(+)	`TGCTGC/TTCCCT`	2	--	int¹		0	--	--	--	--
rs190208557^1,2		--	112888472(+)	`AATAGC/TATCAA`	2	--	int¹		0	--	--	--	--
rs17822304^1,2	C,F,H	--	112888692(+)	`CTCGAC/ACAGTT`	2	--	int¹		22		NA NS EA	2554
rs139090081^1,2		--	112889046(+)	`GCTGAC/TAATTT`	2	--	int¹		0	--	--	--	--
rs183083672^1,2		--	112889120(+)	`TCTAAA/GTTTTA`	2	--	int¹		0	--	--	--	--
rs116057339^1,2	F	--	112889315(+)	`CTGTCC/TTTGGA`	2	--	int¹		1		WA	118
rs61175907^1,2	C,F	--	112889655(+)	`TCTGTC/TTCTGT`	2	--	int¹		4		WA CSA NA	242
rs12310199^1,2	C,F,A	--	112889684(+)	`tttttT/Aaattt`	2	--	int¹ trp³		4		NA WA CSA	123
rs149890854^1,2		--	112889740(+)	`AGTGAC/TGCGAT`	2	--	int¹		0	--	--	--	--
rs188532728^1,2		--	112889748(+)	`GATCTC/TGGCTC`	2	--	int¹		0	--	--	--	--
rs76116354^1,2		--	112889922(+)	`TGATCC/TGCCCA`	2	--	int¹		0	--	--	--	--
rs192924784^1,2		--	112890067(+)	`CGCTCA/GTCACC`	2	--	int¹		0	--	--	--	--
rs185513926^1,2		--	112890120(+)	`CCGCCC/TCCCAG`	2	--	int¹		0	--	--	--	--
rs148601443^1,2		--	112890230(+)	`TCACCA/GTGTTG`	2	--	int¹		0	--	--	--	--
rs188970534^1,2		--	112890245(+)	`GGCTGA/GTCTCG`	2	--	int¹		0	--	--	--	--
rs114117154^1,2	F	--	112890405(+)	`TAGCGC/TACTGC`	2	--	int¹		1		WA	118
rs200651902^1,2		--	112890728(+)	`GATTT-/AAAAAA`	2	--	int¹		0	--	--	--	--
rs2301756^1,2	C,F,A,H	--	112890776(-)	`ATGAGC/TCCACA`	2	--	int¹		30		EA NS NA WA CSA	4343
rs112532211^1,2	F	--	112890916(+)	`GAGAGC/TTGACT`	2	--	int¹		2		CSA	6
rs143501327^1,2		--	112890987(+)	`TTTTTA/TAAAAA`	2	--	int¹		0	--	--	--	--
rs146749153^1,2	C	--	112890996(+)	`AACTTC/TAGGTG`	2	--	int¹		0	--	--	--	--
rs199498784^1,2		--	112891092(+)	`CAGAGC/TCACCC`	4	S

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PTPN11 Gene

protein tyrosine phosphatase, non-receptor type 11

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for PTPN11 gene

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for PTPN11 gene

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for PTPN11 gene

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for PTPN11 gene

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Export list of displayed genes

PTPN11 Gene

protein tyrosine phosphatase, non-receptor type 11

Aliasesfor PTPN11 gene

Summariesfor PTPN11 gene

Genomic Viewsfor PTPN11 gene

Proteinsfor PTPN11 gene

Protein Domains /Familiesfor PTPN11 gene

Functionfor PTPN11 gene

Pathways & Interactionsfor PTPN11 gene

Drugs & Compoundsfor PTPN11 gene

Transcriptsfor PTPN11 gene

Expression for PTPN11 gene

Orthologsfor PTPN11 gene

Paralogsfor PTPN11 gene

Genomic Variantsfor PTPN11 gene

Aliases
for PTPN11 gene

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for PTPN11 gene

Genomic Views
for PTPN11 gene

Proteins
for PTPN11 gene

Protein Domains /
Families
for PTPN11 gene

Function
for PTPN11 gene

Pathways & Interactions
for PTPN11 gene

Drugs & Compounds
for PTPN11 gene

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for PTPN11 gene

Expression
for PTPN11 gene

Orthologs
for PTPN11 gene

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for PTPN11 gene

Genomic Variants
for PTPN11 gene