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PTPN11 Gene

protein-coding   GIFtS: 76
GCID: GC12P112856

Protein Tyrosine Phosphatase, Non-Receptor Type 11

(Previous name: Noonan syndrome 1)
(Previous symbol: NS1)
  See PTPN11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 111 2     EC 3.1.3.483 8
NS11 2 5     SHP22 5
PTP2C2 3 5     Noonan Syndrome 11
Protein-Tyrosine Phosphatase 1D2 3     BPTP32
Protein-Tyrosine Phosphatase 2C2 3     CFC2
PTP-1D2 3     Tyrosine-Protein Phosphatase Non-Receptor Type 112
PTP-2C2 3     SHP-23
SH-PTP22 3     SHPTP23
SH-PTP32 3     Shp23

External Ids:    HGNC: 96441   Entrez Gene: 57812   Ensembl: ENSG000001792957   OMIM: 1768765   UniProtKB: Q061243   

Export aliases for PTPN11 gene to outside databases

Previous GC identifers: GC12P111712 GC12P112333 GC12P112639 GC12P111268 GC12P111319 GC12P109868


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPN11 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function
as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is
widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important
for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and
cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for PTPN11 Gene:
PTPN11 (protein tyrosine phosphatase, non-receptor type 11) is a protein-coding gene. Diseases associated with PTPN11 include ptpn11-related noonan syndrome, and ptpn11-related leopard syndrome. GO annotations related to this gene include SH3/SH2 adaptor activity and protein domain specific binding. An important paralog of this gene is PTPN1.

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the
signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in
stimulatation of its RhoA binding activity

summary for PTPN11 Gene:
Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups
from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of
kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. PTPs
are cysteine-dependent phosphatases that contain a conserved C[X]5R motif essential for enzymatic activity.
PTPs are currently divided into five subtypes; tyrosine-specific phosphatases (e.g. PTP1B), dual specificity
phosphatases (DSPs) (e.g. DUSP1), Cdc25 phosphatases (e.g. Cdc25A), myotubularin-related phosphatases (e.g.
MTMR13) and low molecular weight phosphatases (e.g. PTPase A). Perturbations in PTP activity has been
implicated in human diseases, including type II diabetes. PTPs have been identified as a negative regulator
of the insulin signaling by dephosphorylating phosphotyrosine residues of insulin receptor kinase. In
cancers, PTPs dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation.

Gene Wiki entry for PTPN11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPN11 gene promoter:
         AP-2alpha isoform 3   STAT3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN11 promoter sequence
   Search Chromatin IP Primers for PTPN11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.1

PTPN11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN11 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P112856:  view genomic region     (about GC identifiers)

Start:
112,856,155 bp from pter      End:
112,947,717 bp from pter
Size:
91,563 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 11  
Size: 597 amino acids; 68436 Da
Subunit: Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB and INPP5D/SHIP1 (By similarity).
Interacts with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3
(tyrosine-phosphorylated), FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine
phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts
with PTPNS1 and CD84. Interacts with phosphorylated SIT1 and MPZL1. Interacts with FCRL3, FCRL4, FCRL6 and
ANKHD1. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT;
the interaction retains TERT in the nucleus. Interacts with PECAM1 and FER. Interacts with EPHA2 (activated);
participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream signaling. Interacts with ROS1; mediates PTPN11
phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this interaction increases the PTPN11
phosphatase activity. Interacts with GAREM isoform 1 (tyrosine phosphorylated); the interaction increases
MAPK/ERK activity and does not affect the GRB2/SOS complex formation
Selected PDB 3D structures from and Proteopedia for PTPN11 (see all 13):
2SHP (3D)        3B7O (3D)        3MOW (3D)        3O5X (3D)        3TKZ (3D)        3TL0 (3D)    
Secondary accessions: A8K1D9 Q96HD7
Alternative splicing: 3 isoforms:  Q06124-1   Q06124-2   Q06124-3   

Explore the universe of human proteins at neXtProt for PTPN11: NX_Q06124

Explore proteomics data for PTPN11 at MOPED

Post-translational modifications: 

  • Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding
    site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3.
    Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated
    PDGFRB1
  • Ubiquitination2 at Lys594
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTPN11 (Q06124) (see all 20)
     WPDHGVP  SRRWFHP  DPTSERW  VVHCSAG 


    See PTPN11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002825.3  NP_542168.1  

    ENSEMBL proteins: 
     ENSP00000376376   ENSP00000340944   ENSP00000437013  
    Reactome Protein details: Q06124

    PTPN11 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PTPN11 Protein
    R&D Systems Recombinant & Natural Proteins for PTPN11 (SHP-2)
    Enzo Life Sciences proteins for PTPN11
    OriGene Purified Protein for PTPN11
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for PTPN11
    OriGene Custom Protein Services for PTPN11
    GenScript Custom Purified and Recombinant Proteins Services for PTPN11
    Novus Biologicals PTPN11 Proteins
    Novus Biologicals PTPN11 Lysates
    Sino Biological Recombinant Protein for PTPN11
    Sino Biological Cell Lysate for PTPN11
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTPN11

     
    Search eBioscience for Proteins for PTPN11 

     
    antibodies-online proteins for PTPN11 (8 products) 

     
    antibodies-online peptides for PTPN11

    PTPN11 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTPN11
    R&D Systems Antibodies for PTPN11 (SHP-2)
    Cell Signaling Technology (CST) Antibodies for PTPN11  (SHP-2)
    OriGene Antibodies for PTPN11
    OriGene Custom Antibody Services for PTPN11
    Novus Biologicals PTPN11 Antibodies
    Abcam antibodies for PTPN11
    Cloud-Clone Corp. Antibodies for PTPN11
    ThermoFisher Antibody for PTPN11
    antibodies-online antibodies for PTPN11 (289 products) 

    PTPN11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTPN11
    R&D Systems ELISAs for PTPN11 (SHP-2)         (see all)
    GenScript Custom Assay Services for PTPN11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTPN11
    Cloud-Clone Corp. CLIAs for PTPN11
    Search eBioscience for ELISAs for PTPN11 
    antibodies-online kits for PTPN11 (23 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    5 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase
     IPR000980 SH2
     IPR012152 Tyr_Pase_non-rcpt_typ-6/11

    Graphical View of Domain Structure for InterPro Entry Q06124

    ProtoNet protein and cluster: Q06124

    2 Blocks protein domains:
    IPB000242 Protein tyrosine phosphatase signature
    IPB000980 SH2 domain signature


    UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
    Domain: The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing
    proteins relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily
    Similarity: Contains 2 SH2 domains
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPN11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN11_HUMAN, Q06124
    Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the
    signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in
    stimulatation of its RhoA binding activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN11:
    protein tyrosine phosphatase,non receptor type 11,with two SH2 domains,expressed in heart,brain,skeletal muscle
    with homology to Drosophila corkscrew,involved in intracellular signal transduction in response to
    PDGF,EGF,insulin,interacting with protein zero related (PZR) for cell signaling,overexpressed in neutrophils
    cells from patients with severe congenital neutropenia (defective dephosphorylation of proteins involved in
    signaling pathways)

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity IDA15133037
    GO:0004725protein tyrosine phosphatase activity TAS--
    GO:0004726non-membrane spanning protein tyrosine phosphatase activity TAS--
    GO:0005070SH3/SH2 adaptor activity IDA7493946
    GO:0005158insulin receptor binding IPI7493946
         
    Find genes that share ontologies with PTPN11           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PTPN11:
     Decreased focal adhesion (FA)   Increased cell death in breast  Increased cell number in G2M,   Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 16 alleles(MGI details for Ptpn11) (see all 26):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    Find genes that share phenotypes with PTPN11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTPN11: Ptpn11tm1Rbn Ptpn11tm2Bgn Ptpn11tm1.2Cbm Ptpn11tm1Paw

       genOway: Develop your customized and physiologically relevant rodent model for PTPN11

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTPN11:
    hsa-mir-23a-3p (MIRT007150), hsa-mir-489-3p (MIRT003549), hsa-mir-183-5p (MIRT047153), hsa-mir-320a (MIRT044548), hsa-mir-130b-5p (MIRT038301), hsa-mir-181a-5p (MIRT006482), hsa-mir-124-3p (MIRT022573), hsa-mir-218-5p (MIRT024234), hsa-mir-193b-3p (MIRT041308)

    Block miRNA regulation of human, mouse, rat PTPN11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPN11 (see all 92):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-1260b hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3916 hsa-miR-489
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PTPN11
    Predesigned siRNA for gene silencing in human, mouse, rat PTPN11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTPN11

    Clone
    Products:
         
    OriGene clones in human, mouse for PTPN11 (see all 7)
    OriGene ORF clones in mouse, rat for PTPN11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTPN11 (NM_002834)
    Sino Biological Human cDNA Clone for PTPN11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11
    Addgene plasmids for PTPN11 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTN11_HUMAN, Q06124: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton3
    plasma membrane3
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15133037
    GO:0005737cytoplasm IDA10940933
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0043234protein complex IEA--

    Find genes that share ontologies with PTPN11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPN11 About   (see all 89)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Neurotrophin signaling pathway0.36
    2FGFR ligand binding and activation
    FRS2-mediated cascade0.70
    Development FGF family signaling0.43
    Negative regulation of FGFR signaling0.56
    Spry regulation of FGF signaling0.00
    3Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    Regulation of IFNA signaling0.69
    4Translation Insulin regulation of translation
    Development CNTF receptor signaling0.43
    ErbB2/ErbB3 signaling events0.31
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    5Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39


    Find genes that share SuperPaths with PTPN11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for PTPN11
        Adipocytokines & Insulin Signaling
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    VEGF - VEGF R2 Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPN11
        Epithelial Adherens Junctions

    3 Cell Signaling Technology (CST) Pathways for PTPN11
        Phosphatases
    MAP Kinase Signaling
    Apoptosis and Autophagy

    Selected GeneGo (Thomson Reuters) Pathways for PTPN11 (see all 24)
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Development FGF-family signaling
    Development CNTF receptor signaling
    Development Thrombopoetin signaling via JAK-STAT pathway
    Chemotaxis CXCR4 signaling pathway

    Selected BioSystems Pathways for PTPN11 (see all 47)
        Heart Development
    EGFR1 Signaling Pathway
    Insulin Signaling
    Type II interferon signaling (IFNG)
    Oncostatin M Signaling Pathway


    Selected Reactome Pathways for PTPN11 (see all 26)
        Regulation of IFNA signaling
    Interferon alpha/beta signaling
    Costimulation by the CD28 family
    Prolactin receptor signaling
    FRS2-mediated cascade


    Selected Kegg Pathways  (Kegg details for PTPN11) (see all 11):
        Ras signaling pathway
    Jak-STAT signaling pathway
    Natural killer cell mediated cytotoxicity
    Leukocyte transendothelial migration
    Neurotrophin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTPN11: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat
              Huntington's Disease in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPN11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTPN11 (Q061241, 2, 3 ENSP000003409444) via UniProtKB, MINT, STRING, and/or I2D (see all 399)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234078Q083451, 2, 3, ENSP000004013974EBI-297779,EBI-711879 MINT-74882 MINT-74883 MINT-74885 MINT-8035995 I2D: score=3 STRING: ENSP00000401397
    ENSG00000137332Q083451, 2, 3EBI-297779,EBI-711879 MINT-74882 MINT-74883 MINT-74885 MINT-8035995 I2D: score=3 
    ENSG00000215522Q083451, 2, 3EBI-297779,EBI-711879 MINT-74882 MINT-74883 MINT-74885 MINT-8035995 I2D: score=3 
    ENSG00000230456Q083451, 2, 3EBI-297779,EBI-711879 MINT-74882 MINT-74883 MINT-74885 MINT-8035995 I2D: score=3 
    GAB1Q134801, 2, 3, ENSP000002629954EBI-297779,EBI-517684 MINT-6169355 MINT-6169300 MINT-6169451 MINT-6169344 MINT-8025571 MINT-8029574 MINT-6169406 MINT-6169374 MINT-8029606 MINT-8288652 MINT-8025555 MINT-7026140 MINT-6169338 MINT-6169389 MINT-6169309 MINT-6169327 MINT-6169291 MINT-8029590 I2D: score=10 STRING: ENSP00000262995
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IEA--
    GO:0000187activation of MAPK activity IEA--
    GO:0006470protein dephosphorylation ----
    GO:0006629lipid metabolic process ----
    GO:0006641triglyceride metabolic process IEA--

    Find genes that share ontologies with PTPN11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PTPN11
      Browse compounds at ApexBio 

    Compounds for PTPN11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Alexidine dihydrochlorideSelective inhibitor of PTPMT1[1715-30-6]
    Sodium orthovanadateProtein tyrosine phosphatase inhibitor[13721-39-6]
    TCS 401Selective inhibitor of PTP1B[243967-42-2]
    BVT 948Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling[39674-97-0]
    NSC 87877Potent inhibitor of shp2 and shp1 PTP[56990-57-9]

    2 HMDB Compounds for PTPN11    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PTPN11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dodecane-Trimethylamine-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for PTPN11 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 89.3 917 9129156 (6), 9582366 (6), 7629070 (6), 19275884 (5) (see all 99)
    phosphotyrosine 82 54 12731888 (2), 11684012 (2), 7681217 (1), 8890167 (1) (see all 41)
    gp 130 72.8 61 10946280 (4), 12593670 (4), 9285712 (3), 12403768 (3) (see all 26)
    phosphatidylinositol 69.5 62 9632795 (3), 8647870 (3), 9565634 (2), 10397152 (2) (see all 45)
    phenylalanine 47.8 12 8622663 (1), 8943348 (1), 9756938 (1), 8959326 (1) (see all 10)
    phenylarsine oxide 47.7 2 7935386 (1)
    inositol 46.3 17 10651806 (1), 11709085 (1), 10623804 (1), 17984366 (1) (see all 16)
    ly294002 44.4 2 14762163 (1), 11335710 (1)
    sodium orthovanadate 42.6 1 10540326 (1)
    echistatin 41.1 5 12399420 (3), 16195423 (1)



    Find genes that share compounds with PTPN11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTPN11 gene (2 alternative transcripts): 
    NM_002834.3  NM_080601.1  

    Unigene Cluster for PTPN11:

    Protein tyrosine phosphatase, non-receptor type 11
    Hs.506852  [show with all ESTs]
    Unigene Representative Sequence: NM_002834
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531326 ENST00000392597(uc001ttw.1) ENST00000351677(uc001ttx.3)
    ENST00000530818
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PTPN11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPN11 (see all 92):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-1260b hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3916 hsa-miR-489
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PTPN11
    Predesigned siRNA for gene silencing in human, mouse, rat PTPN11
    Clone
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    OriGene clones in human, mouse for PTPN11 (see all 7)
    OriGene ORF clones in mouse, rat for PTPN11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTPN11 (NM_002834)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11
    Addgene plasmids for PTPN11 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PTPN11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPN11
      QuantiTect SYBR Green Assays in human, mouse, rat PTPN11
      QuantiFast Probe-based Assays in human, mouse, rat PTPN11

    Additional mRNA sequence: 

    AK289854.1 AK312147.1 BC007869.2 BC008692.1 BC025181.1 BC030949.1 BT007106.1 BX537632.1 
    D13540.1 EU779706.1 EU779707.1 EU779708.1 L03535.1 L07527.1 L08807.1 S78088.1 
    U79291.1 X70766.1 

    18 DOTS entries:

    DT.411692  DT.99944225  DT.91769243  DT.100733832  DT.100656212  DT.121153732  DT.95354784  DT.121153765 
    DT.120647580  DT.70100615  DT.95127024  DT.100783460  DT.121153563  DT.121153748  DT.91871508  DT.92421803 
    DT.120843678  DT.99974908 

    Selected AceView cDNA sequences (see all 1484):

    BG898041 BU526614 AW405946 AI967970 F27501 AA374206 CF128365 BX114871 
    BI227225 CR603976 AA307193 BM705443 BM473884 AA360905 BE394537 CR599701 
    BU185398 BE383217 CB149157 AA644222 BF589532 CA941003 BE888230 BM802399 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPN11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATGTTGA
    PTPN11 Expression
    About this image


    PTPN11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PTPN11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPN11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506852

    UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
    Tissue specificity: Widely expressed, with highest levels in heart, brain, and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTPN11: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat
              Huntington's Disease in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PTPN11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPN11
    QuantiTect SYBR Green Assays in human, mouse, rat PTPN11
    QuantiFast Probe-based Assays in human, mouse, rat PTPN11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTPN11 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn111 , 5 protein tyrosine phosphatase, non-receptor type 111, 5 87.24(n)1
    99.49(a)1
      5 (61.72 cM)5
    192471  NM_011202.31  NP_035332.11 
     1211305335 
    chicken
    (Gallus gallus)
    Aves PTPN111 protein tyrosine phosphatase, non-receptor type 11 85.33(n)
    98.31(a)
      395815  NM_204968.1  NP_990299.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN116
    protein tyrosine phosphatase, non-receptor type 11...
    97(a)
    1 ↔ 1
    GL343282.1(325794-344135)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.9362 Xenopus laevis phosphotyrosyl-protein phosphatase mRNA, more 82.68(n)    U15287.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi24f032 wufi24f03 78.16(n)   333979  BC045328.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta csw1 , 3 EGF receptor signaling pathway protein
    tyrosine more3
    corkscrew1
    66(a)3
    61.59(n)1
    66.8(a)1
      452781  NM_001272245.11  NP_001259174.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ptp-23 PROTEIN-TYROSINE PHOSPHATASE 37(a)
    (best of 3)
      II(5918677-5920933)   --


    ENSEMBL Gene Tree for PTPN11 (if available)
    TreeFam Gene Tree for PTPN11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPN11 gene
    PTPN12  PTPN222  PTPN92  PTPN62  PTPRN22  PTPRN2  PTPN142  PTPN212  
    PTPN20B2  PTPN22  PTPN122  PTPN182  PTPN20A2  
    18 SIMAP similar genes for PTPN11 using alignment to 6 protein entries:     PTN11_HUMAN (see all proteins):
    PTPN6    GRB2    NCK1    GRAP2    VAV3    SHF
    RASA1    CLNK    CSK    VAV1    PIK3R3    SH2B2
    HCK    SHC4    MATK    FYN    LCK    SYK

    Find genes that share paralogs with PTPN11           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for PTPN11 (see all 6)
    PGOHUM00000244574 PGOHUM00000237709 PGOHUM00000245615 PGOHUM00000235162 PGOHUM00000243393


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPN11 (see all 1464)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0271864
    Noonan syndrome 1 (NS1)4--see VAR_0271862 Q P mis40--------
    VAR_0156184
    Noonan syndrome 1 (NS1)4--see VAR_0156182 N S mis40--------
    VAR_0660604
    Noonan syndrome 1 (NS1)4--see VAR_0660602 T A mis40--------
    VAR_0156224
    Noonan syndrome 1 (NS1)4--see VAR_0156222 R K mis40--------
    VAR_0156074
    Noonan syndrome 1 (NS1)4--see VAR_0156072 A G mis40--------
    VAR_0156174
    Noonan syndrome 1 (NS1)4--see VAR_0156172 F L mis40--------
    VAR_0271974
    Noonan syndrome 1 (NS1)4--see VAR_0271972 L F mis40--------
    VAR_0156234
    Noonan syndrome 1 (NS1)4--see VAR_0156232 S T mis40--------
    VAR_0156044
    Noonan syndrome 1 (NS1)4--see VAR_0156042 D N mis40--------
    VAR_0271934
    LEOPARD syndrome 1 (LEOPARD1)4--see VAR_0271932 R W mis40--------

    HapMap Linkage Disequilibrium report for PTPN11 (112856155 - 112947717 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PTPN11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746369CNV Deletion23290073
    esv2661618CNV Deletion23128226
    nsv889CNV Loss18451855
    nsv899524CNV Gain21882294

    Human Gene Mutation Database (HGMD): PTPN11
    Selected Site Specific Mutation Identification with PCR Assays for PTPN11 (see all 16):
    Cosmic IdAA Change
    13014p.A72T
    13026p.E76A
    13000p.E76K
    13025p.E76V
    13020p.S502P
    Selected Site Specific Cancer Mutation PCR Panels containing PTPN11 (see all 6):
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Lymphoid Neoplasms
    Hematopoietic Neoplasms
    c-MET
    Cancer Comprehensive Panel 384HT
    SeqTarget long-range PCR primers for resequencing PTPN11
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPN11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176876   
    OMIM disorders: 163950  151100  607785  156250  
    UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
  • LEOPARD syndrome 1 (LEOPARD1) [MIM:151100]: A disorder characterized by lentigines, electrocardiographic
    conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of
    growth, and sensorineural deafness. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Noonan syndrome 1 (NS1) [MIM:163950]: A form of Noonan syndrome, a disease characterized by short
    stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated
    ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can
    include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits,
    multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk
    of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of
    myelomonocytic cells. Some patients with NS1 develop multiple giant cell lesions of the jaw or other bony or soft
    tissues, which are classified as pigmented villonodular synovitis (PVNS) when occurring in the jaw or joints.
    Note=The disease is caused by mutations affecting the gene represented in this entry. Mutations in PTPN11 account
    for more than 50% of the cases
  • Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic
    syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell
    compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes,
    rashes, and hemorrhages. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Metachondromatosis (MC) [MIM:156250]: A skeletal disorder with radiologic features of both multiple
    exostoses and Ollier disease, characterized by the presence of exostoses, commonly of the bones of the hands and
    feet, and enchondromas of the metaphyses of long bones and iliac crest. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for PTPN11 (see all 21):    
    About MalaCards
    ptpn11-related noonan syndrome    ptpn11-related leopard syndrome    noonan syndrome 1    metachondromatosis
    pulmonary valve stenosis    dengue hemorrhagic fever    leopard syndrome    noonan syndrome
    noonan-like/multiple giant cell lesion syndrome    juvenile myelomonocytic leukemia    leopard syndrome 1    neurofibromatosis-noonan syndrome
    neurofibromatosis    noma    cherubism    cardiofaciocutaneous syndrome
    ollier disease    microsporidiosis    influenza    myeloid leukemia

    10 diseases from the University of Copenhagen DISEASES database for PTPN11:
    Noonan syndrome     LEOPARD syndrome     Juvenile myelomonocytic leukemia     Pulmonary valve stenosis
    Costello syndrome     Diabetes mellitus     Hypertrophic cardiomyopathy     Congenital heart defect
    Leukemia     Hypersensitivity reaction type II disease

    Find genes that share disorders with PTPN11           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PTPN11 gene (see all 85)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noonan syndrome 96.2 192 17020470 (4), 18348260 (4), 12161469 (4), 15985475 (3) (see all 99)
    leopard syndrome 93.4 63 15690106 (4), 16679933 (3), 14991917 (3), 16208280 (2) (see all 38)
    juvenile myelomonocytic leukemia 90.3 32 15928039 (2), 15604238 (2), 12717436 (2), 15211660 (2) (see all 26)
    cfc syndrome 88.7 10 18651097 (2), 12384786 (2), 12529707 (2), 20052757 (1) (see all 6)
    neurofibromatosis-noonan syndrome 82.8 3 17020470 (2), 19449407 (1)
    lentigines 79.1 5 19582499 (1), 15470362 (1), 16733669 (1), 18470943 (1) (see all 5)
    short stature 77.6 15 15985475 (1), 16498234 (1), 16804314 (1), 20383758 (1) (see all 15)
    heart defects congenital 70.3 12 18203203 (3), 16461457 (2), 12960218 (1), 20461756 (1) (see all 9)
    pulmonary valve stenosis 66.1 6 11992261 (1), 18678287 (1), 12522798 (1), 17515436 (1) (see all 5)
    x-linked lymphoproliferative syndrome 65.1 1 11313386 (1)

    GeneTests: PTPN11
    GeneReviews: PTPN11
    Genetic Association Database (GAD): PTPN11
    Human Genome Epidemiology (HuGE) Navigator: PTPN11 (48 documents)

    Export disorders for PTPN11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPN11 gene, integrated from 10 sources (see all 1248) (see top 10):
    (articles sorted by number of sources associating them with PTPN11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome. (PubMed id 19020799)1, 2, 4, 9 Ko J.M.... Yoo H.W. (J. Hum. Genet. 2008)
    2. Identification of a human src homology 2-containing protein-tyrosine- phosphatase: a putative homolog of Drosophila corkscrew. (PubMed id 1280823)1, 2, 3, 9 Freeman R.M. Jr.... Neel B.G. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    3. PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype- phenotype correlation, and phenotypic heterogeneity. (PubMed id 11992261)1, 2, 4, 9 Tartaglia M.... Gelb B.D. (Am. J. Hum. Genet. 2002)
    4. Polymorphisms of PTPN11 coding SHP-2 as biomarkers for ulcerative colitis susceptibility in the Japanese population. (PubMed id 19160029)1, 4, 9 Narumi Y....Tsukamoto K. (J. Clin. Immunol. 2009)
    5. Analysis of the PTPN11 gene in idiopathic short stature children and Noonan syndrome patients. (PubMed id 18331608)1, 4, 9 Ferreira L.V....Jorge A.A. (Clin. Endocrinol. (Oxf) 2008)
    6. PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. (PubMed id 16533526)1, 4, 9 Yamamoto T....Kojma S. (Leuk. Res. 2006)
    7. PTPN11 (protein tyrosine phosphatase, nonreceptor type 11) mutations and response to growth hormone therapy in children with Noonan syndrome. (PubMed id 15956085)1, 4, 9 Ferreira L.V....Jorge A.A. (J. Clin. Endocrinol. Metab. 2005)
    8. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). (PubMed id 20170098)1, 2, 9 Zhang X.... Zhang Z.Y. (J. Med. Chem. 2010)
    9. Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. (PubMed id 19047918)1, 4, 9 Yoshida N....Kojima S. (Pediatr. Res. 2009)
    10. Genetic heterogeneity in LEOPARD syndrome: two families with no mutations in PTPN11. (PubMed id 15690106)1, 2, 9 Kalidas K.... Jeffery S. (J. Hum. Genet. 2005)
    11. Acute myelomonocytic leukemia in a boy with LEOPARD syndrome (PTPN11 gene mutation positive). (PubMed id 16679933)1, 2, 9 Ucar C.... Heinritz W. (J. Pediatr. Hematol. Oncol. 2006)
    12. Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). (PubMed id 11433379)1, 2, 9 Pfrepper K.-I.... Schraven B. (Eur. J. Immunol. 2001)
    13. Investigation of gene dosage imbalances in patients with Noonan syndrome using multiplex ligation-dependent probe amplification analysis. (PubMed id 20302979)1, 4, 9 NystrAPm A.M....Bondeson M.L. (Eur J Med Genet 2010)
    14. Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. (PubMed id 17910045)1, 4, 9 Paulsson K....Johansson B. (amp 2008)
    15. Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase. (PubMed id 18829466)1, 2, 9 Jakob S.... Haendeler J. (J. Biol. Chem. 2008)
    16. [Phenotype variability in Noonan syndrome patients with and without PTPN11 mutation]. (PubMed id 17546245)1, 4, 9 Ferreira L.V....Jorge A.A. (Arq Bras Endocrinol Metabol 2007)
    17. Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy. (PubMed id 17211494)1, 4, 9 Goto Y....Hamajima N. (Int J Med Sci 2007)
    18. PTPN11 gene analysis in 74 Brazilian patients with Noonan syndrome or Noonan-like phenotype. (PubMed id 17020470)1, 4, 9 Bertola D.R....Krieger J.E. (Genet. Test. 2006)
    19. The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. (PubMed id 15928039)1, 4, 9 Kratz C.P....Loh M.L. (Blood 2005)
    20. Genetics and variation in phenotype in Noonan syndrome. (PubMed id 15539800)1, 4, 9 Jongmans M....van der Burgt I. (Horm. Res. 2004)
    21. A novel PTPN11 mutation in LEOPARD syndrome. (PubMed id 14961557)1, 2, 9 Conti E.... Dallapiccola B. (Hum. Mutat. 2003)
    22. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. (PubMed id 12717436)1, 2, 9 Tartaglia M.... Gelb B.D. (Nat. Genet. 2003)
    23. PTPN11 mutations in Noonan syndrome type I: detection of recurrent mutations in exons 3 and 13. (PubMed id 12325025)1, 2, 9 Maheshwari M.... Gibbs R.A. (Hum. Mutat. 2002)
    24. PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome. (PubMed id 12161469)1, 2, 9 Kosaki K.... Ogata T. (J. Clin. Endocrinol. Metab. 2002)
    25. Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. (PubMed id 11414741)1, 2, 9 Lewis J.... Duckett C.S. (Clin. Immunol. 2001)
    26. Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs. (PubMed id 10681522)1, 2, 9 Zhao R. and Zhao Z.J. (J. Biol. Chem. 2000)
    27. A family of proteins that inhibit signalling through tyrosine kinase receptors. (PubMed id 9062191)1, 2, 9 Kharitonenkov A....Ullrich A. (Nature 1997)
    28. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. (PubMed id 8041791)1, 2, 9 Bennett A.M.... Neel B.G. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    29. Cloning, expression and mutational analysis of SH-PTP2, human protein-tyrosine phosphatase. (PubMed id 8216283)1, 2, 9 Bastien L.... Adam M. (Biochem. Biophys. Res. Commun. 1993)
    30. Effects of germline mutations in the Ras/MAPK signaling pathway on adaptive behavior: cardiofaciocutaneous syndrome and Noonan syndrome. (PubMed id 20186801)1, 4, 9 Pierpont E.I....Seidenberg M.S. (Am. J. Med. Genet. A 2010)
    31. PTPN11 mutations in childhood acute lymphoblastic leukemia occur as a secondary event associated with high hyperdiploidy. (PubMed id 19776760)1, 4, 9 Molteni C.G....Cazzaniga G. (Leukemia 2010)
    32. Mitochondrial DNA haplogroup 'R' is associated with Noonan syndrome of south India. (PubMed id 20006740)1, 4, 9 Rani D.S....Thangaraj K. (Mitochondrion 2009)
    33. High resolution melting analysis for mutation detection for PTPN11 gene: applications of this method for diagnosis of Noonan syndrome. (PubMed id 19737548)1, 4, 9 Lo F.S....Chiou C.C. ( international journal of clinical chemistry 2009)
    34. Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade. (PubMed id 19133693)1, 4, 9 Cesarini L....Zampino G. (Am. J. Med. Genet. A 2009)
    35. Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum. (PubMed id 19206169)1, 4, 9 Sarkozy A.... Tartaglia M. (Hum. Mutat. 2009)
    36. Genome wide molecular analysis of minimally differentiated acute myeloid leukemia. (PubMed id 19773259)1, 4, 9 Silva F.P....Giphart-Gassler M. (Haematologica 2009)
    37. Associations between a PTPN11 polymorphism and gastric atrophy--opposite in Uzbekistan to that in Japan. (PubMed id 18712962)1, 4, 9 Hamajima N....Goto Y. (Asian Pac. J. Cancer Prev. 2008)
    38. The spectrum of cardiac anomalies in Noonan syndrome as a result of mutations in the PTPN11 gene. (PubMed id 17515436)1, 4, 9 Sznajer Y....Verloes A. (Pediatrics 2007)
    39. Mutational analysis of PTPN11 gene in Taiwanese children with Noonan syndrome. (PubMed id 17339163)1, 4, 9 Hung C.S....Lo F.S. (J. Formos. Med. Assoc. 2007)
    40. Clinical variability in a Noonan syndrome family with a new PTPN11 gene mutation. (PubMed id 15384080)1, 2, 9 Bertola D.R....Krieger J.E. (Am. J. Med. Genet. A 2004)
    41. Genotype-phenotype correlations in Noonan syndrome. (PubMed id 15001945)1, 4, 9 Zenker M....Rauch A. (J. Pediatr. 2004)
    42. Two novel and one recurrent PTPN11 mutations in LEOPARD syndrome. (PubMed id 15389709)1, 2, 9 Yoshida R.... Ogata T. (Am. J. Med. Genet. A 2004)
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    109. Recruitment of the tyrosine phosphatase Src homology 2 domain tyrosine phosphatase-2 to the p85 subunit of phosphatidylinositol-3 (PI-3) kinase is required for insulin-like growth factor-I-dependent PI-3 kinase activation in smooth muscle cells. (PubMed id 16306077)1, 9 Kwon M....Clemmons D.R. (Endocrinology 2006)
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    117. A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice. (PubMed id 9847309)1, 9 Harris C.E.... Astell C.R. (J. Virol. 1999)
    118. Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases. (PubMed id 8995399)1, 9 Yin T....Yang Y.C. (J. Biol. Chem. 1997)
    119. Significance of SHP-1 and SHP-2 expression in human papillomavirus infected Condyloma acuminatum and cervical cancer. (PubMed id 18543080)1, 9 Tao X.H....Jin R. (Pathol. Oncol. Res. 2008)
    120. SHP-2 is a novel target of Abl kinases during cell proliferation. (PubMed id 18827006)1, 9 Mitra S....Plattner R. (J. Cell. Sci. 2008)
    121. An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway. (PubMed id 16963136)1, 9 Vatinel S....Seva C. (Biochim. Biophys. Acta 2006)
    122. Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies. (PubMed id 16518851)1, 9 Chen Y....Hayashi Y. (amp 2006)
    123. Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2. (PubMed id 15985432)1, 9 Tai L.K....Berk B.C. (J. Biol. Chem. 2005)
    124. PTPN11 mutations play a minor role in isolated congenital heart disease. (PubMed id 15940693)1, 9 Weismann C.G....Gelb B.D. (Am. J. Med. Genet. A 2005)
    125. PTPN11 mutations are associated with mild growth hormone resistance in individuals with Noonan syndrome. (PubMed id 15985475)1, 9 Binder G....Wittekindt N.E. (J. Clin. Endocrinol. Metab. 2005)
    126. Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation. (PubMed id 12370245)1, 9 Cai T....Khavari P.A. (J. Cell Biol. 2002)
    127. Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells. (PubMed id 12060651)1, 9 Chughtai N....Ali S. (J. Biol. Chem. 2002)
    128. Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2. (PubMed id 11323411)1, 9 Cunnick J.M....Wu J. (J. Biol. Chem. 2001)
    129. Association of tyrosine phosphatase SHP-2 with F-actin at low cell densities. (PubMed id 11382784)1, 9 Xu F....Zhao Z.J. (J. Biol. Chem. 2001)
    130. SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells. (PubMed id 10880513)1, 9 Chauhan D....Anderson K.C. (J. Biol. Chem. 2000)
    131. Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons. (PubMed id 10386953)1, 9 Yamada M....Hatanaka H. (J. Neurochem. 1999)
    132. Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival. (PubMed id 9254654)1, 9 Pazdrak K....Alam R. (J. Exp. Med. 1997)
    133. Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia. (PubMed id 16030196)1, 9 Xu R....Feng G.S. (Blood 2005)
    134. Molecular interactions of SHP1 and SHP2 in IL-3-signalling. (PubMed id 11812650)1, 9 Wheadon H....Welham M.J. (Cell. Signal. 2002)
    135. Potential involvement of FRS2 in insulin signaling. (PubMed id 10650943)1, 9 Delahaye L....Van Obberghen E. (Endocrinology 2000)
    136. Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31. (PubMed id 10350061)1, 9 Pumphrey N.J....Buckley C.D. (FEBS Lett. 1999)
    137. SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates. (PubMed id 9162089)1, 9 Bone H....Welham M.J. (J. Biol. Chem. 1997)
    138. Association of SH2 domain protein tyrosine phosphatases with the epidermal growth factor receptor in human tumor cells. Phosphatidic acid activates receptor dephosphorylation by PTP1C. (PubMed id 7673163)1, 9 Tomic S....BAPhmer F.D. (J. Biol. Chem. 1995)
    139. Calpain-dependent cleavage of SHP-1 and SHP-2 is involved in the dephosphorylation of Jurkat T cells induced by Entamoeba histolytica. (PubMed id 20398180)1, 9 Kim K.A....Shin M.H. (Parasite Immunol. 2010)
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    141. Electrocardiography in Noonan syndrome PTPN11 gene mutation--phenotype characterization. (PubMed id 18203203)1, 9 Croonen E.A....Draaisma J.M. (Am. J. Med. Genet. A 2008)
    142. Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions. (PubMed id 16250012)1, 9 Herrera Abreu M.T....Downey G.P. (J. Cell. Physiol. 2006)
    143. KIR2DL5 can inhibit human NK cell activation via recruitment of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2). (PubMed id 15187115)1, 9 Yusa S....Campbell K.S. (J. Immunol. 2004)
    144. Familial aggregation of genetically heterogeneous hypertrophic cardiomyopathy: a boy with LEOPARD syndrome due to PTPN11 mutation and his nonsyndromic father lacking PTPN11 mutations. (PubMed id 14991917)1, 9 Digilio M.C....Dallapiccola B. (Birth Defects Res. Part A Clin. Mol. Teratol. 2004)
    145. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. (PubMed id 12403768)1, 9 Lehmann U....Schaper F. (J. Biol. Chem. 2003)
    146. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. (PubMed id 10777583)1, 9 Schmitz J....Schaper F. (J. Biol. Chem. 2000)
    147. Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. (PubMed id 10747947)1, 9 Ganju R.K....Groopman J.E. (J. Biol. Chem. 2000)
    148. SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin. (PubMed id 10681592)1, 9 Ukropec J.A....Woolkalis M.J. (J. Biol. Chem. 2000)
    149. Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells. (PubMed id 10080542)1, 9 Zhang S.... Broxmeyer H.E. (J. Leukoc. Biol. 1999)
    150. Formation of distinct signalling complexes involving phosphatidylinositol 3-kinase activity with stimulation of epidermal growth factor or insulin-like growth factor-I in human skin fibroblasts. (PubMed id 9886492)1, 9 Takahashi Y....Kadowaki T. (J. Cell. Physiol. 1999)
    151. The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. (PubMed id 9867848)1, 9 Huber M....Beauchemin N. (J. Biol. Chem. 1999)
    152. Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates. (PubMed id 9774457)1, 9 Hua C.T....Jackson D.E. (J. Biol. Chem. 1998)
    153. Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene. (PubMed id 9422771)1, 9 Kuroiwa A....Takai T. (J. Biol. Chem. 1998)
    154. Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2. (PubMed id 19096001)1, 9 Korporaal S.J....Akkerman J.W. (Arterioscler. Thromb. Vasc. Biol. 2009)
    155. Dopamine regulates phosphorylation of VEGF receptor 2 by engaging Src-homology-2-domain-containing protein tyrosine phosphatase 2. (PubMed id 19706677)1, 9 Sinha S....Mukhopadhyay D. (J. Cell. Sci. 2009)
    156. Redox regulation of SH2-domain-containing protein tyrosine phosphatases by two backdoor cysteines. (PubMed id 19166311)1, 9 Chen C.Y....Rudolph J. (Biochemistry 2009)
    157. Duplication of chromosome band 12q24.11q24.23 results in apparent Noonan syndrome. (PubMed id 18348260)1, 9 Shchelochkov O.A....Sutton V.R. (Am. J. Med. Genet. A 2008)
    158. Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls. (PubMed id 18728972)1, 9 Fridberg M....Wingren A.G. (Pediatr Hematol Oncol 2008)
    159. PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. (PubMed id 17053061)1, 9 Chan R.J. and Feng G.S. (Blood 2007)
    160. The Lipoxin A4 receptor is coupled to SHP-2 activation: implications for regulation of receptor tyrosine kinases. (PubMed id 17403678)1, 9 Mitchell D....Godson C. (J. Biol. Chem. 2007)
    161. Increased insulin-stimulated Akt pSer473 and cytosolic SHP2 protein abundance in human skeletal muscle following acute exercise and short-term training. (PubMed id 17185494)1, 9 Wadley G.D....Cameron-Smith D. (J. Appl. Physiol. 2007)
    162. Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor. (PubMed id 14665621)1, 9 Ren Y....Wu J. (J. Biol. Chem. 2004)
    163. SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor. (PubMed id 14522994)1, 9 Ali S....Ali S. (J. Biol. Chem. 2003)
    164. The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa. (PubMed id 12552462)1, 9 Yamazaki S....Azuma T. (J. Infect. Dis. 2003)
    165. PTPN11 mutations are not responsible for the Cardiofaciocutaneous (CFC) syndrome. (PubMed id 12529707)1, 9 Kavamura M.I....Neri G. (Eur. J. Hum. Genet. 2003)
    166. PTPN11 mutations in LEOPARD syndrome. (PubMed id 12161596)1, 9 Legius E....Fryns J.P. (J. Med. Genet. 2002)
    167. Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. (PubMed id 11986327)1, 9 Angata T....Varki A. (J. Biol. Chem. 2002)
    168. Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1. (PubMed id 12176037)1, 9 Caselli A....Ramponi G. (Biochem. Biophys. Res. Commun. 2002)
    169. Absence of PTPN11 mutations in 28 cases of cardiofaciocutaneous (CFC) syndrome. (PubMed id 12384786)1, 9 Ion A....Jeffery S. (Hum. Genet. 2002)
    170. G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2. (PubMed id 11544253)1, 9 de Vet E.C.M.... Campbell R.D. (J. Biol. Chem. 2001)
    171. Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation. (PubMed id 10617656)1, 9 Yu C.L....Burakoff S.J. (J. Biol. Chem. 2000)
    172. p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells. (PubMed id 9918857)1, 9 Zhang S. and Broxmeyer H.E. (Biochem. Biophys. Res. Commun. 1999)
    173. Fcgamma receptor-mediated inhibition of human B cell activation: the role of SHP-2 phosphatase. (PubMed id 10382761)1, 9 Koncz G....SA!rmay G. (Eur. J. Immunol. 1999)
    174. Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation. (PubMed id 9535915)1, 9 Takada T....Kasuga M. (J. Biol. Chem. 1998)
    175. Epidermal growth factor induces coupling of protein-tyrosine phosphatase 1D to GRB2 via the COOH-terminal SH3 domain of GRB2. (PubMed id 8702859)1, 9 Wong L. and Johnson G.R. (J. Biol. Chem. 1996)
    176. Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells. (PubMed id 8541543)1, 9 Mu S.X....Saris C.J. (Blood 1995)
    177. Insulin receptor kinase phosphorylates protein tyrosine phosphatase containing Src homology 2 regions and modulates its PTPase activity in vitro. (PubMed id 8135823)1, 9 Maegawa H....Kashiwagi A. (Biochem. Biophys. Res. Commun. 1994)
    178. Integrin beta4 attenuates SHP-2 and MAPK signaling and reduces human lung endothelial inflammatory responses. (PubMed id 20512931)1, 9 Chen W....Jacobson J.R. (J. Cell. Biochem. 2010)
    179. Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling. (PubMed id 20308328)1, 9 Edouard T....Raynal P. (Mol. Cell. Biol. 2010)
    180. Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations. (PubMed id 20237506)1, 9 Davidsson J....Johansson B. (Leukemia 2010)
    181. LEOPARD syndrome with recurrent PTPN11 mutation Y279C and different cutaneous manifestations: two case reports and a review of the literature. (PubMed id 19768645)1, 9 Kalev I....Ounap K. (Eur. J. Pediatr. 2010)
    182. Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells. (PubMed id 20080972)1, 9 Carver K.C....Schuler L.A. (J. Biol. Chem. 2010)
    183. Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia. (PubMed id 19874312)1, 9 Matsuda K....Koike K. (Br. J. Haematol. 2010)
    184. Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development. (PubMed id 20237281)1, 9 Cai Z....Zhang X. (J. Neurosci. 2010)
    185. The tyrosine phosphatase SHP-2 controls urokinase-dependent signaling and functions in human vascular smooth muscle cells. (PubMed id 19133257)1, 9 Kiyan J....Dumler I. (Exp. Cell Res. 2009)
    186. A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase. (PubMed id 19290061)1, 9 Wu D....Feng G.S. (PLoS ONE 2009)
    187. Independent NF1 and PTPN11 mutations in a family with neurofibromatosis-Noonan syndrome. (PubMed id 19449407)1, 9 Thiel C....Rauch A. (Am. J. Med. Genet. A 2009)
    188. Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. (PubMed id 19509418)1, 9 Zhang W....Shou W. (J. Biol. Chem. 2009)
    189. The protein-tyrosine phosphatase, SRC homology-2 domain containing protein tyrosine phosphatase-2, is a crucial mediator of exogenous insulin-like growth factor signaling to human trophoblast. (PubMed id 19589868)1, 9 Forbes K....Westwood M. (Endocrinology 2009)
    190. Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese. (PubMed id 19589142)1, 9 Hishida A....Hamajima N. (BMC Gastroenterol 2009)
    191. PTPN11 gene mutation and severe neonatal hypertrophic cardiomyopathy: what is the link? (PubMed id 19582499)1, 9 Faienza M.F....Cavallo L. (Pediatr Cardiol 2009)
    192. RAS signaling dysregulation in human embryonal Rhabdomyosarcoma. (PubMed id 19681119)1, 9 Martinelli S....Dominici C. (amp 2009)
    193. Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation. (PubMed id 19261604)1, 9 Zhou X. and Agazie Y.M. (J. Biol. Chem. 2009)
    194. PTPN11 mutations in LEOPARD syndrome: report of four cases in Taiwan. (PubMed id 19864201)1, 9 Lin I.S....Lin S.J. (J. Formos. Med. Assoc. 2009)
    195. Phenotype-genotype correlation in a patient with co-occurrence of Marfan and LEOPARD syndromes. (PubMed id 19725129)1, 9 Tang S....Matsuoka R. (Am. J. Med. Genet. A 2009)
    196. Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathway. (PubMed id 18577518)1, 9 Koyama T....Mochizuki N. (J. Biol. Chem. 2008)
    197. Inhibition of IFN-gamma-induced STAT1 tyrosine phosphorylation by human CMV is mediated by SHP2. (PubMed id 18832710)1, 9 Baron M. and Davignon J.L. (J. Immunol. 2008)
    198. Diverse driving forces underlie the invariant occurrence of the T42A, E139D, I282V and T468M SHP2 amino acid substitutions causing Noonan and LEOPARD syndromes. (PubMed id 18372317)1, 9 Martinelli S....Tartaglia M. (Hum. Mol. Genet. 2008)
    199. Hodgkin's lymphoma in a patient with Noonan syndrome with germ-line PTPN11 mutations. (PubMed id 18758896)1, 9 Lo F.S....Kuo M.C. (Int. J. Hematol. 2008)
    200. Long-term GH treatment improves adult height in children with Noonan syndrome with and without mutations in protein tyrosine phosphatase, non-receptor-type 11. (PubMed id 18562489)1, 9 Noordam C....Otten B.J. (Eur. J. Endocrinol. 2008)
    201. Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo. (PubMed id 17962719)1, 9 Mannell H....Krotz F. (J. Vasc. Res. 2008)
    202. Mutations of the PTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocations. (PubMed id 17330262)1, 9 Christiansen D.H....Pedersen-Bjergaard J. (amp 2007)
    203. Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2. (PubMed id 17717529)1, 9 Coyne C.B....Bergelson J.M. (EMBO J. 2007)
    204. Structural and functional effects of disease-causing amino acid substitutions affecting residues Ala72 and Glu76 of the protein tyrosine phosphatase SHP-2. (PubMed id 17177198)1, 9 Bocchinfuso G....Palleschi A. (Proteins 2007)
    205. The tyrosine phosphatase SHP-2 regulates differentiation and apoptosis of individual primary T lymphocytes. (PubMed id 17330819)1, 9 Hoff H. and Brunner-Weinzierl M.C. (Eur. J. Immunol. 2007)
    206. Regulation of growth hormone signaling by selective estrogen receptor modulators occurs through suppression of protein tyrosine phosphatases. (PubMed id 17272397)1, 9 Leung K.C....Ho K.K. (Endocrinology 2007)
    207. SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women. (PubMed id 17214991)1, 9 Jamshidi Y....O'Dell S.D. (Atherosclerosis 2007)
    208. Mild variable Noonan syndrome in a family with a novel PTPN11 mutation. (PubMed id 17052965)1, 9 Zenker M....Reis A. (Eur J Med Genet 2007)
    209. Germline gain-of-function mutations in SOS1 cause Noonan syndrome. (PubMed id 17143285)1, 9 Roberts A.E....Kucherlapati R.S. (Nat. Genet. 2007)
    210. Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL. (PubMed id 17942397)1, 9 Ren Y....Wu J. (J. Biol. Chem. 2007)
    211. Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2. (PubMed id 17561098)1, 9 Weibrecht I....BAPhmer F.D. (amp 2007)
    212. Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome. (PubMed id 16598312)1, 9 Chen C.Y....Tien H.F. (Leukemia 2006)
    213. Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease. (PubMed id 16358218)1, 9 Tartaglia M....Gelb B.D. (Am. J. Hum. Genet. 2006)
    214. The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells. (PubMed id 16825188)1, 9 Lieskovska J....Clemmons D.R. (J. Biol. Chem. 2006)
    215. A PTPN11 gene mutation (Y63C) causing Noonan syndrome is not associated with short stature in general population. (PubMed id 16498234)1, 9 Takahashi I....Koizumi A. (Tohoku J. Exp. Med. 2006)
    216. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. (PubMed id 16885344)2, 9 Charest A.... Housman D. (Cancer Res. 2006)
    217. ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells. (PubMed id 16956752)2, 9 Traina F.... Saad S.T.O. (Biochim. Biophys. Acta 2006)
    218. Mutation screening of the PTPN11 gene in hypertrophic cardiomyopathy. (PubMed id 16488201)1, 9 Limongelli G....Syrris P. (Eur J Med Genet 2006)
    219. LEOPARD syndrome: clinical diagnosis in the first year of life. (PubMed id 16523510)1, 9 Digilio M.C....Dallapiccola B. (Am. J. Med. Genet. A 2006)
    220. Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor. (PubMed id 15644411)1, 9 Chan R.J....Kapur R. (Blood 2005)
    221. Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia. (PubMed id 15834506)1, 9 Niihori T....Matsubara Y. (J. Hum. Genet. 2005)
    222. Germ-line and somatic PTPN11 mutations in human disease. (PubMed id 16053901)1, 9 Tartaglia M. and Gelb B.D. (Eur J Med Genet 2005)
    223. Noonan syndrome type I with PTPN11 3 bp deletion: structure-function implications. (PubMed id 15521065)1, 9 Lee W.H....Parfait B. (Proteins 2005)
    224. Mutations of PTPN11 are rare in adult myeloid malignancies. (PubMed id 15951301)1, 9 Hugues L....Preudhomme C. (Haematologica 2005)
    225. Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2. (PubMed id 15708852)1, 9 Sturla L.M....Schmidt-Ullrichr R.K. (J. Biol. Chem. 2005)
    226. Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes. (PubMed id 15987685)1, 9 Keilhack H....Neel B.G. (J. Biol. Chem. 2005)
    227. Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor. (PubMed id 15507525)1, 9 Gallicchio M.... Bussolino F. (Blood 2005)
    228. Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia. (PubMed id 15725481)1, 9 Loh M.L....Tartaglia M. (Leuk. Res. 2005)
    229. Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells. (PubMed id 15888547)1, 9 Ling Y....Clemmons D.R. (Mol. Biol. Cell 2005)
    230. PTPN11 mutations and genotype-phenotype correlations in Noonan and LEOPARD syndromes. (PubMed id 16208280)1, 9 Ogata T. and Yoshida R. (Pediatr Endocrinol Rev 2005)
    231. Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells. (PubMed id 14701753)1, 9 Kapoor G.S....O'Rourke D.M. (Mol. Cell. Biol. 2004)
    232. SHP2 binds catalase and acquires a hydrogen peroxide-resistant phosphatase activity via integrin-signaling. (PubMed id 15556604)1, 9 Yano S....Yano N. (FEBS Lett. 2004)
    233. Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. (PubMed id 15031289)1, 9 Hanafusa H....Nishida E. (J. Biol. Chem. 2004)
    234. Phosphorylation of Grb2-associated binder 2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation. (PubMed id 15356145)1, 9 Arnaud M....Bertoglio J. (J. Immunol. 2004)
    235. Mutations in PTPN11 are rare in adult myelodysplastic syndromes and acute myeloid leukemia. (PubMed id 15282682)1, 9 Watkins F....Wainscoat J.S. (Am. J. Hematol. 2004)
    236. Exclusion of PTPN11 mutations in Costello syndrome: further evidence for distinct genetic etiologies for Noonan, cardio-facio-cutaneous and Costello syndromes. (PubMed id 12752577)1, 9 Tartaglia M....Rauen K.A. (Clin. Genet. 2003)
    237. Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) can play a direct role in the inhibitory function of killer cell Ig-like receptors in human NK cells. (PubMed id 12707331)1, 9 Yusa S. and Campbell K.S. (J. Immunol. 2003)
    238. Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells. (PubMed id 12972546)2, 9 Kogata N....Mochizuki N. (Mol. Biol. Cell 2003)
    239. Hepatitis C virus and HIV envelope proteins collaboratively mediate interleukin-8 secretion through activation of p38 MAP kinase and SHP2 in hepatocytes. (PubMed id 12824191)1, 9 Balasubramanian A....Groopman J.E. (J. Biol. Chem. 2003)
    240. The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit. (PubMed id 12444928)1, 9 Wollberg P....Ronnstrand L. (Biochem. J. 2003)
    241. Development of an efficient &quot;substrate-trapping&quot; mutant of Src homology phosphotyrosine phosphatase 2 and identification of the epidermal growth factor receptor, Gab1, and three other proteins as target substrates. (PubMed id 12582165)1, 9 Agazie Y.M. and Hayman M.J. (J. Biol. Chem. 2003)
    242. The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3. (PubMed id 14534538)1, 9 Agazie Y.M.... Hayman M.J. (Oncogene 2003)
    243. The inhibitory potential of Fc receptor homolog 4 on memory B cells. (PubMed id 14597715)2, 9 Ehrhardt G.R.A....Cooper M.D. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    244. Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling. (PubMed id 14560030)1, 9 Agazie Y.M. and Hayman M.J. (Mol. Cell. Biol. 2003)
    245. SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor. (PubMed id 11896619)1, 9 Ekman S....RAPnnstrand L. (Oncogene 2002)
    246. Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. (PubMed id 11786908)1, 9 Daigle I....Simon H.U. (Nat. Med. 2002)
    247. Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. (PubMed id 11806999)1, 9 Howie D....Terhorst C. (Blood 2002)
    248. The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta. (PubMed id 11781100)1, 9 Strack V....HAoring H.U. (Biochemistry 2002)
    249. The alphaVbeta3 integrin regulates insulin-like growth factor I (IGF-I) receptor phosphorylation by altering the rate of recruitment of the Src-homology 2-containing phosphotyrosine phosphatase-2 to the activated IGF-I receptor. (PubMed id 12399420)1, 9 Maile L.A. and Clemmons D.R. (Endocrinology 2002)
    250. Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor. (PubMed id 11136824)1, 9 You M....Feng G.S. (J. Exp. Med. 2001)
    251. SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways. (PubMed id 11157475)1, 9 Chernock R.D....Ganju R.K. (Blood 2001)
    252. A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor. (PubMed id 11134009)1, 9 Yart A....Raynal P. (J. Biol. Chem. 2001)
    253. Influence of the somatostatin receptor sst2 on growth factor signal cascades in human glioma cells. (PubMed id 11223155)1, 9 Held-Feindt J....Mentlein R. (Brain Res. Mol. Brain Res. 2001)
    254. mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2. (PubMed id 11171044)1, 9 Yu Z....Shen S. (Biochem. J. 2001)
    255. A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners. (PubMed id 11334882)1, 9 Crouin C....Bertoglio J. (FEBS Lett. 2001)
    256. Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2. (PubMed id 11278955)1, 9 Ulyanova T....Thomas M.L. (J. Biol. Chem. 2001)
    257. Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin. (PubMed id 11594781)1, 9 Gunaje J.J. and Bhat G.J. (Biochem. Biophys. Res. Commun. 2001)
    258. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. (PubMed id 11018044)1, 9 Bjorbak C....Myers M.G. (J. Biol. Chem. 2000)
    259. Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation. (PubMed id 10946280)1, 9 Anhuf D....Schaper F. (J. Immunol. 2000)
    260. Differential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathways. (PubMed id 10800945)1, 9 Bartoe J.L. and Nathanson N.M. (J. Neurochem. 2000)
    261. Subcellular localization of intracellular protein tyrosine phosphatases in T cells. (PubMed id 10940933)1, 9 Gjoerloff-Wingren A.... Mustelin T. (Eur. J. Immunol. 2000)
    262. Inhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs). (PubMed id 10962556)1, 9 Wu C.J....O'Rourke D.M. (Oncogene 2000)
    263. H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1. (PubMed id 10457220)1, 9 Daws M.R....Sentman C.L. (Immunology 1999)
    264. Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1. (PubMed id 10327049)1, 9 Maeda A....Kurosaki T. (Oncogene 1999)
    265. The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. (PubMed id 10206955)1, 9 Taylor V.C....Freeman S.D. (J. Biol. Chem. 1999)
    266. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. (PubMed id 9632781)1, 9 Hadari Y.R....Schlessinger J. (Mol. Cell. Biol. 1998)
    267. The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor. (PubMed id 9804835)1, 9 Ingham R.J....Gold M.R. (J. Biol. Chem. 1998)
    268. The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling. (PubMed id 9756938)1, 9 Myers M.G....White M.F. (J. Biol. Chem. 1998)
    269. Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2. (PubMed id 9756944)1, 9 Crovello C.S....Carraway K.L. (J. Biol. Chem. 1998)
    270. SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. (PubMed id 9528781)1, 9 Kozlowski M....Siminovitch K.A. (Mol. Cell. Biol. 1998)
    271. Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated stimulation of mitogen-activated protein kinase. Evidence for participation of multiple signaling pathways which converge at Ras. (PubMed id 9195977)1, 9 Schiemann W.P....Nathanson N.M. (J. Biol. Chem. 1997)
    272. The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signaling. (PubMed id 9054388)1, 9 Jackson D.E....Newman P.J. (J. Biol. Chem. 1997)
    273. Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cells. (PubMed id 9188788)1, 9 Masuda M....Fujiwara K. (FEBS Lett. 1997)
    274. Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2. (PubMed id 9110989)1, 9 Liu L....Krystal G. (J. Biol. Chem. 1997)
    275. Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways. (PubMed id 8890167)1, 9 Roche S....Courtneidge S.A. (EMBO J. 1996)
    276. SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates. (PubMed id 8912646)1, 9 Maegawa H....Kikkawa R. (Biochem. Biophys. Res. Commun. 1996)
    277. Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584. (PubMed id 8959326)1, 9 Vogel W. and Ullrich A. (amp 1996)
    278. A tyrosine-phosphorylated 110-120-kDa protein associates with the C-terminal SH2 domain of phosphotyrosine phosphatase-1D in T cell receptor-stimulated T cells. (PubMed id 8766558)1, 9 Frearson J.A....Alexander D.R. (Eur. J. Immunol. 1996)
    279. Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction. (PubMed id 7493946)1, 9 Kharitonenkov A....Ullrich A. (J. Biol. Chem. 1995)
    280. Chromosomal localization of an SH2 containing tyrosine phosphatase (SH-PTP3) gene to chromosome 12q24.1. (PubMed id 8183573)1, 9 Isobe M....Adachi M. (Oncogene 1994)
    281. Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase. (PubMed id 7522233)1, 9 Welham M.J....Schrader J.W. (J. Biol. Chem. 1994)
    282. Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells. (PubMed id 24285539)1 Okon I.S....Zou M.H. (J. Biol. Chem. 2014)
    283. Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum. (PubMed id 24431450)1 Li K....Li J.Y. (J. Neurosci. 2014)
    284. Low expression of SHP-2 is associated with less favorable prostate cancer outcomes. (PubMed id 23192641)1 Tassidis H....Wingren A.G. (Tumour Biol. 2013)
    285. Targeting the yin and the yang: combined inhibition of the tyrosine kinase c-Src and the tyrosine phosphatase SHP-2 disrupts pancreatic cancer signaling and biology in vitro and tumor formation in vivo. (PubMed id 23271399)1 Gomes E.G....Summy J.M. (Pancreas 2013)
    286. Atrioventricular canal defect in patients with RASopathies. (PubMed id 22781091)1 Digilio M.C....Dallapiccola B. (Eur. J. Hum. Genet. 2013)
    287. Increased expression of tyrosine phosphatase SHP-2 in Helicobacter pylori-infected gastric cancer. (PubMed id 23382639)1 Jiang J....Cao X.Y. (World J. Gastroenterol. 2013)
    288. Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility. (PubMed id 23401857)1 Zhang X....Roux P.P. (Mol. Cell. Biol. 2013)
    289. Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase. (PubMed id 23318428)1 Miura K....Mochizuki N. (Oncogene 2013)
    290. Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function. (PubMed id 23082805)1 Broxmeyer H.E....Chan R.J. (Stem Cells Dev. 2013)
    291. Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants. (PubMed id 23822953)1 Iwai L.K....Huang P.H. (Biochem. J. 2013)
    292. Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. (PubMed id 23980151)1 Sha F....Hantschel O. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    293. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 KAPttgen A....Gieger C. (Nat. Genet. 2013)
    294. Age-dependent germline mosaicism of the most common noonan syndrome mutation shows the signature of germline selection. (PubMed id 23726368)1 Yoon S.R....Arnheim N. (Am. J. Hum. Genet. 2013)
    295. Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2. (PubMed id 23792876)1 Sun J....Wang Y. (Nat Commun 2013)
    296. Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. (PubMed id 23297363)1 Cordell H.J....Goodship J.A. (Hum. Mol. Genet. 2013)
    297. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. (PubMed id 23269672)1 Yu J....Feng G.S. (J. Biol. Chem. 2013)
    298. Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. (PubMed id 23335101)1 Stanford S.M....Bottini N. (Arthritis Rheum. 2013)
    299. Structural and mechanistic insights into LEOPARD syndrome-associated SHP2 mutations. (PubMed id 23457302)1 Yu Z.H....Zhang Z.Y. (J. Biol. Chem. 2013)
    300. Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations. (PubMed id 22777356)1 Furcht C.M....Lazzara M.J. (Oncogene 2013)
    301. Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice. (PubMed id 23530062)1 Coulombe G....Rivard N. (Mol. Cell. Biol. 2013)
    302. IGF-I generation test in prepubertal children with Noonan syndrome due to mutations in the PTPN11 gene. (PubMed id 23624134)1 Bertelloni S....Simi P. (Hormones (Athens) 2013)
    303. Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia. (PubMed id 23584145)1 MA1ller P.J....Sobota R.M. (J Proteomics 2013)
    304. Polymorphisms of PTPN11 gene could influence serum lipid levels in a sex-specific pattern. (PubMed id 23672255)1 Jia Z.F....Jiang J. (Lipids Health Dis 2013)
    305. Medulloblastoma in a patient with the PTPN11 p.Thr468Met mutation. (PubMed id 23813970)1 Rankin J....Hanemann C.O. (Am. J. Med. Genet. A 2013)
    306. SHP-2 phosphatase promotes cervical cancer cell proliferation through inhibiting interferon-I^ production. (PubMed id 22889324)1 Meng F....Zhang S. (J. Obstet. Gynaecol. Res. 2013)
    307. Helicobacter pylori-related host gene polymorphisms associated with susceptibility of gastric carcinogenesis: a two-stage case-control study in Chinese. (PubMed id 23455381)1 He C....Yuan Y. (Carcinogenesis 2013)
    308. Scalp melanoma in a woman with LEOPARD syndrome: possible implication of PTPN11 signaling in melanoma pathogenesis. (PubMed id 24034393)1 Cheng Y.P....Liao Y.H. (J. Am. Acad. Dermatol. 2013)
    309. SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells. (PubMed id 23363816)1 Leibowitz M.S....Ferris R.L. (Clin. Cancer Res. 2013)
    310. Src homology 2-containing protein tyrosine phosphatase-2 acts as a negative regulator for MUC5AC transcription via the inhibition of the ERK1/2 MAPK signalling pathway in the airway. (PubMed id 23582017)1 Song K.S....Ahn D.W. (Acta Physiol (Oxf) 2013)
    311. Selective sequestration of STAT1 in the cytoplasm via phosphorylated SHP-2 ameliorates murine experimental colitis. (PubMed id 22942432)1 Wu X....Xu Q. (J. Immunol. 2012)
    312. Counteracting effects operating on Src homology 2 domain-containing protein-tyrosine phosphatase 2 (SHP2) function drive selection of the recurrent Y62D and Y63C substitutions in Noonan syndrome. (PubMed id 22711529)1 Martinelli S....Tartaglia M. (J. Biol. Chem. 2012)
    313. Expression and clinical significance of SHP2 in gastric cancer. (PubMed id 23321164)1 Dong S....Yu J.R. (J. Int. Med. Res. 2012)
    314. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    315. SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome. (PubMed id 22974441)1 Liu B.A....Nash P.D. (Cell Commun. Signal 2012)
    316. The tumor suppressor role of Src homology phosphotyrosine phosphatase 2 in hepatocellular carcinoma. (PubMed id 22228034)1 Jiang C....Wei L. (J. Cancer Res. Clin. Oncol. 2012)
    317. Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling. (PubMed id 22711165)1 Dittrich A....Schaper F. (Mol Biosyst 2012)
    318. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    319. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. (PubMed id 22806893)1 Mali R.S....Kapur R. (Blood 2012)
    320. CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines. (PubMed id 22043923)1 Kim E.J....Lee W.H. (Immunology 2012)
    321. The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of I^-catenin phosphorylation. (PubMed id 22956765)1 Timmerman I....van Buul J.D. (Mol. Biol. Cell 2012)
    322. Novel associations for hypothyroidism include known autoimmune risk loci. (PubMed id 22493691)1 Eriksson N....Do C.B. (PLoS ONE 2012)
    323. Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability. (PubMed id 22890240)1 Liu X....Qu C.K. (Cancer Res. 2012)
    324. Association of polymorphism of PTPN 11 encoding SHP-2 with gastric atrophy but not gastric cancer in Helicobacter pylori seropositive Chinese population. (PubMed id 22788847)1 Jiang J....Cao X. (BMC Gastroenterol 2012)
    325. Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis. (PubMed id 22869052)1 Li S....Feng G.S. (Front Med 2012)
    326. Protein tyrosine phosphatase SHP2 mediates chronic insulin-induced endothelial inflammation. (PubMed id 22628433)1 Giri H....Dixit M. (Arterioscler. Thromb. Vasc. Biol. 2012)
    327. SHP-2 and PTP-pest induction during Rb-E2F associated apoptosis. (PubMed id 22644489)1 Morales L.D....Lieman J.H. (amp 2012)
    328. [Analysis of PTPN11 mutation in children leukemia and its clinical significance]. (PubMed id 22391158)1 Yang S.Z....Chen C. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2012)
    329. Reactive oxygen species and epidermal growth factor are antagonistic cues controlling SHP-2 dimerization. (PubMed id 22411627)1 Nardozza A.P....Castagnoli L. (Mol. Cell. Biol. 2012)
    330. LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane. (PubMed id 22589543)1 Draber P....Brdicka T. (J. Biol. Chem. 2012)
    331. A common variant in the PTPN11 gene contributes to the risk of tetralogy of Fallot. (PubMed id 22503907)1 Goodship J.A....Keavney B. (Circ Cardiovasc Genet 2012)
    332. Shp2 function in hematopoietic stem cell biology and leukemogenesis. (PubMed id 22504523)1 Nabinger S.C. and Chan R.J. (Curr. Opin. Hematol. 2012)
    333. Response to growth hormone therapy in children with Noonan syndrome: correlation with or without PTPN11 gene mutation. (PubMed id 22777296)1 Choi J.H....Yoo H.W. (Horm Res Paediatr 2012)
    334. Shp2 plays an important role in acute cigarette smoke-mediated lung inflammation. (PubMed id 22891281)1 Li F.F....Ke Y. (J. Immunol. 2012)
    335. The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner. (PubMed id 23065156)1 Fraineau S....Benzakour O. (Blood 2012)
    336. Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytes. (PubMed id 23029125)1 Mamik M.K. and Ghorpade A. (PLoS ONE 2012)
    337. Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart. (PubMed id 23045525)1 Burmeister B.T....Carnegie G.K. (J. Biol. Chem. 2012)
    338. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    339. Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2. (PubMed id 22629427)1 Hatanaka K....Simons M. (PLoS ONE 2012)
    340. Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints. (PubMed id 23189174)1 Tsang Y.H....Poon R.Y. (PLoS ONE 2012)
    341. A possible role of different PTPN genes in immune regulation. (PubMed id 22260263)1 Quaio C.R....Bertola D.R. (Scand. J. Immunol. 2012)
    342. Phenotypic spectrum of 80 Greek patients referred as Noonan syndrome and PTPN11 mutation analysis: the value of initial clinical assessment. (PubMed id 21590266)1 Papadopoulou A....Kitsiou-Tzeli S. (Eur. J. Pediatr. 2012)
    343. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)1 Gieger C....Soranzo N. (Nature 2011)
    344. Myeloproliferative disorder in Noonan syndrome. (PubMed id 20829714)1 Bastida P....Sanchez de Toledo J. (J. Pediatr. Hematol. Oncol. 2011)
    345. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (Nat. Biotechnol. 2011)
    346. Recovery of anoikis in Src-transformed cells and human breast carcinoma cells by restoration of the SIRP I+1/SHP-2 signaling system. (PubMed id 21169408)1 Hara K....Hamaguchi M. (Cancer Res. 2011)
    347. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    348. Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. (PubMed id 21575863)1 Bard-Chapeau E.A....Feng G.S. (Cancer Cell 2011)
    349. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    350. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    351. OPLS-DA as a suitable method for selecting a set of gene transcripts discriminating RAS- and PTPN11-mutated cells in acute lymphoblastic leukaemia. (PubMed id 20958258)1 Musumarra G....Fortuna C.G. (amp 2011)
    352. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PubMed id 21572416)1 Kato N....He J. (Nat. Genet. 2011)
    353. [Construction and expression of eukaryotic expression vector of NS1 protein of influenza A (H1N1)]. (PubMed id 21419049)1 Zhang W.S....Jiao Y.J. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011)
    354. Cancer risk in patients with Noonan syndrome carrying a PTPN11 mutation. (PubMed id 21407260)1 Jongmans M.C....Hoogerbrugge N. (Eur. J. Hum. Genet. 2011)
    355. PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots? (PubMed id 22681964)1 Lauriol J. and Kontaridis M.I. (Trends Cardiovasc. Med. 2011)
    356. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor contains an immunoreceptor tyrosine-based inhibitory motif that activates Shp2. (PubMed id 21047965)1 Philpott N....Cannon M. (J. Virol. 2011)
    357. Lymphocyte cell-cycle inhibition by HLA-G is mediated by phosphatase SHP-2 and acts on the mTOR pathway. (PubMed id 21887223)1 Ketroussi F....Durrbach A. (PLoS ONE 2011)
    358. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PubMed id 21507922)4 Ramsuran V....Ndung'u T. (Clin. Infect. Dis. 2011)
    359. Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4. (PubMed id 21903867)1 Cooke M....Cornejo Maciel F. (J. Lipid Res. 2011)
    360. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (Cell 2011)
    361. Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations. (PubMed id 21068439)1 Bauler T.J....King P.D. (amp 2011)
    362. SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are prognosis-related in colorectal cancer. (PubMed id 21528083)1 Yu S.J....Zheng S. (World J. Gastroenterol. 2011)
    363. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)
    364. Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway. (PubMed id 21531714)1 Quintanar-Audelo M....Guy G.R. (J. Biol. Chem. 2011)
    365. Co-occurring SHOC2 and PTPN11 mutations in a patient with severe/complex Noonan syndrome-like phenotype. (PubMed id 21548061)1 Ekvall S....Bondeson M.L. (Am. J. Med. Genet. A 2011)
    366. Tyrosine phosphatases as key regulators of StAR induction and cholesterol transport: SHP2 as a potential tyrosine phosphatase involved in steroid synthesis. (PubMed id 21145937)1 Cooke M....PodestA! E.J. (Mol. Cell. Endocrinol. 2011)
    367. Loss-of-function mutations in PTPN11 cause metachondromatosis, but not Ollier disease or Maffucci syndrome. (PubMed id 21533187)1 Bowen M.E....Warman M.L. (PLoS Genet. 2011)
    368. A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells. (PubMed id 21670473)1 Li L....Bhatia R. (Blood 2011)
    369. Germline PTPN11 mutation affecting exon 8 in a case of syndromic juvenile myelomonocytic leukemia. (PubMed id 21106241)1 Prontera P....Donti E. (Leuk. Res. 2011)
    370. PLCI^1-SHP-2 complex, PLCI^1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling? (PubMed id 21663700)1 CalA^ L.A....Clari G. (J. Biomed. Sci. 2011)
    371. Structural mechanism associated with domain opening in gain-of-function mutations in SHP2 phosphatase. (PubMed id 21365683)1 Darian E....MacKerell A.D. (Proteins 2011)
    372. SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver. (PubMed id 21726809)1 Takahashi A....Hatakeyama M. (Mol. Cell 2011)
    373. SHP2 mediates the localized activation of Fyn downstream of the I+6I^4 integrin to promote carcinoma invasion. (PubMed id 20855525)1 Yang X....Shaw L.M. (Mol. Cell. Biol. 2010)
    374. Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration. (PubMed id 20494825)2 Wardega P.... Lennartsson J. (Cell. Signal. 2010)
    375. miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC). (PubMed id 20700123)1 Kikkawa N....Seki N. (Br. J. Cancer 2010)
    376. The phosphatase Shp2 is required for signaling by the Kaposi's sarcoma-associated herpesvirus viral GPCR in primary endothelial cells. (PubMed id 20004456)1 Bakken T....Cannon M.L. (Virology 2010)
    377. Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase. (PubMed id 19909739)1 Cholay M.... Daviet L. (Exp. Cell Res. 2010)
    378. A mother and son with Noonan syndrome resulting from a PTPN11 mutation: first report of molecularly proven cases from Turkey. (PubMed id 20718194)1 Demir K....BAPber E. (Turk. J. Pediatr. 2010)
    379. PTPN11 and KRAS gene analysis in patients with Noonan and Noonan-like syndromes. (PubMed id 20578946)1 Brasil A.S....Bertola D.R. (Genet Test Mol Biomarkers 2010)
    380. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    381. Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function. (PubMed id 19735729)1 Ahmed Z....Ladbury J.E. (Cell. Signal. 2010)
    382. Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells. (PubMed id 20723025)1 Moraes L.A....Gibbins J.M. (J. Thromb. Haemost. 2010)
    383. SHP-2 phosphatase activity is required for PECAM-1-dependent cell motility. (PubMed id 20631249)1 Zhu J.X....Delisser H.M. (Am. J. Physiol., Cell Physiol. 2010)
    384. Noonan syndrome: prenatal diagnosis in a woman carrying a PTPN11 gene mutation. (PubMed id 20064076)1 GonzA!lez-Huerta N.C....Cuevas-Covarrubias S.A. (amp 2010)
    385. Clinical and hematologic findings in Noonan syndrome patients with PTPN11 gene mutations. (PubMed id 20954246)1 Derbent M....A9zbek N. (Am. J. Med. Genet. A 2010)
    386. [Expression and its clinical significance of SHP2 in non-small cell lung cancer]. (PubMed id 20673499)1 Tang C....Zhang R. (Zhongguo Fei Ai Za Zhi 2010)
    387. The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. (PubMed id 20697350)1 Titz B....Graeber T.G. (Oncogene 2010)
    388. Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation. (PubMed id 20671117)1 Meng S....Wang C. (J Mol Cell Biol 2010)
    389. Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1-induced matrix metalloproteinase-3 expression. (PubMed id 20472558)1 Wang Q....McCulloch C.A. (J. Biol. Chem. 2010)
    390. [Expression and clinical significance of SHP2 in the tumor tissues of smokers with lung cancer]. (PubMed id 20840817)1 Zhan X....Wei Z. (Zhongguo Fei Ai Za Zhi 2010)
    391. Overexpression of protein phosphatase non-receptor type 11 (PTPN11) in gastric carcinomas. (PubMed id 19690960)1 Kim J.S....Kim S.S. (Dig. Dis. Sci. 2010)
    392. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. (PubMed id 19738201)1 Humphries J.D....Humphries M.J. (Sci Signal 2009)
    393. Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants. (PubMed id 19528235)1 Yang Z....Chan R.J. (Mol. Cell. Biol. 2009)
    394. JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1. (PubMed id 19287004)1 Yu L....Chen H. (J. Biol. Chem. 2009)
    395. Expression and purification of 15N-labeled 2-SH2 protein domain of SHP-2 from Homo sapiens in Escherichia coli for NMR studies and applications. (PubMed id 19056419)1 Wu Y. and Guo J.F. (Int. J. Biol. Macromol. 2009)
    396. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    397. GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling. (PubMed id 19509291)2 Tashiro K.... Konishi H. (J. Biol. Chem. 2009)
    398. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    399. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    400. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PubMed id 19167335)2 Barr A.J.... Knapp S. (Cell 2009)
    401. A severe form of Noonan syndrome and autosomal dominant cafAc-au-lait spots - evidence for different genetic origins. (PubMed id 19120036)1 NystrAPm A.M....Bondeson M.L. (Acta Paediatr. 2009)
    402. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    403. A novel and critical role for tyrosine 663 in platelet endothelial cell adhesion molecule-1 trafficking and transendothelial migration. (PubMed id 19342684)2 Dasgupta B.... Muller W.A. (J. Immunol. 2009)
    404. Impaired Sertoli cell function in males diagnosed with Noonan syndrome. (PubMed id 19189703)1 Marcus K.A....Noordam C. (amp 2008)
    405. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1 Brummer T.... Daly R.J. (EMBO J. 2008)
    406. Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD. (PubMed id 17972951)1 Hou H.A....Tien H.F. (Leukemia 2008)
    407. Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival. (PubMed id 18640765)1 Yang Z....Chan R.J. (Exp. Hematol. 2008)
    408. An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. (PubMed id 18604210)2 Yu M.-C.... Ge B.-X. (Nat. Immunol. 2008)
    409. Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells. (PubMed id 18617527)1 Simoneau M....Rivard N. (J. Biol. Chem. 2008)
    410. Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia. (PubMed id 18246201)1 Konieczna I....Eklund E.A. (J. Clin. Invest. 2008)
    411. c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130. (PubMed id 18519587)1 Tanaka Y....Sugamura K. (Mol. Cell. Biol. 2008)
    412. The function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clusters. (PubMed id 18647419)1 Qian Y.K....Peng H.B. (BMC Neurosci 2008)
    413. Structural and functional consequences of tyrosine phosphorylation in the LRP1 cytoplasmic domain. (PubMed id 18381291)1 Betts G.N....Komives E.A. (J. Biol. Chem. 2008)
    414. Tyrosine phosphatase SHP-2 is a regulator of p27(Kip1) tyrosine phosphorylation. (PubMed id 19066472)1 Tossidou I....Kardinal C. (Cell Cycle 2008)
    415. How do Shp2 mutations that oppositely influence its biochemical activity result in syndromes with overlapping symptoms? (PubMed id 17453145)1 Edouard T....Raynal P. (Cell. Mol. Life Sci. 2007)
    416. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PubMed id 17903303)4 O'Donnell C.J....Demissie S. (BMC Med. Genet. 2007)
    417. SOCS3 targets Siglec 7 for proteasomal degradation and blocks Siglec 7-mediated responses. (PubMed id 17138568)1 Orr S.J....Johnston J.A. (J. Biol. Chem. 2007)
    418. Early fetal death associated with compound heterozygosity for Noonan syndrome-causative PTPN11 mutations. (PubMed id 17497712)1 Becker K....Tartaglia M. (Am. J. Med. Genet. A 2007)
    419. Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation. (PubMed id 17211446)1 Feng G.S. (Cell Res. 2007)
    420. The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42. (PubMed id 17664338)1 RosA!rio M....Birchmeier W. (J. Cell Biol. 2007)
    421. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)1 Szafranski K....Platzer M. (Genome Biol. 2007)
    422. Regulation of urokinase receptor expression by protein tyrosine phosphatases. (PubMed id 17028265)1 Shetty S....Shetty P.K. (Am. J. Physiol. Lung Cell Mol. Physiol. 2007)
    423. A novel PTPN11 gene mutation in a patient with LEOPARD Syndrome. (PubMed id 17875892)1 Du-Thanh A....Dereure O. (Arch Dermatol 2007)
    424. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    425. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    426. Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2. (PubMed id 16360206)1 Richard M....Beaulieu A.D. (Mol. Immunol. 2006)
    427. Leukemia-associated, constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the interferon consensus sequence binding protein. (PubMed id 16914719)1 Huang W....Eklund E.A. (Mol. Cell. Biol. 2006)
    428. Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2. (PubMed id 16684964)1 Heiss E....Ronnstrand L. (Blood 2006)
    429. A quantitative protein interaction network for the ErbB receptors using protein microarrays. (PubMed id 16273093)1 Jones R.B....MacBeath G. (Nature 2006)
    430. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    431. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    432. Deoxycholic acid differentially regulates focal adhesion kinase phosphorylation: role of tyrosine phosphatase ShP2. (PubMed id 16920701)1 Khare S....Samarel A.M. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006)
    433. Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA. (PubMed id 16354697)1 Tsutsumi R....Hatakeyama M. (Mol. Cell. Biol. 2006)
    434. SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes. (PubMed id 17157259)1 Fujii M....Roberts A.B. (Mol. Cell 2006)
    435. Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1. (PubMed id 16339483)1 Mitola S....Bussolino F. (Circ. Res. 2006)
    436. Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1. (PubMed id 16337946)1 Koo D.H....Vogel W.F. (FEBS Lett. 2006)
    437. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)1 Tao W.A....Aebersold R. (Nat. Methods 2005)
    438. Interferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes. (PubMed id 15601262)1 Halfter U.M....Vaillancourt R.R. (Biochem. J. 2005)
    439. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)1 Zhang Y.... White F.M. (Mol. Cell. Proteomics 2005)
    440. Phosphotyrosine interactome of the ErbB-receptor kinase family. (PubMed id 16729043)1 Schulze W.X....Mann M. (Mol. Syst. Biol. 2005)
    441. Substrate-trapping techniques in the identification of cellular PTP targets. (PubMed id 15588985)1 Blanchetot C....Tremblay M.L. (Methods 2005)
    442. Transformed immortalized gastric epithelial cells by virulence factor CagA of Helicobacter pylori through Erk mitogen-activated protein kinase pathway. (PubMed id 15856031)1 Zhu Y....Xu W. (Oncogene 2005)
    443. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    444. TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2. (PubMed id 15128762)1 Barrow A.D.... Trowsdale J. (J. Immunol. 2004)
    445. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    446. Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. (PubMed id 15062102)1 Ballif B.A....Cooper J.A. (Curr. Biol. 2004)
    447. Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors. (PubMed id 14982882)1 van den Akker E....von Lindern M. (Blood 2004)
    448. Signal transduction via the stem cell factor receptor/c-Kit. (PubMed id 15526160)2 Ronnstrand L. (Cell. Mol. Life Sci. 2004)
    449. A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. (PubMed id 12577067)1 Blagoev B....Mann M. (Nat. Biotechnol. 2003)
    450. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. (PubMed id 12796776)1 Watanabe N.... Murphy K.M. (Nat. Immunol. 2003)
    451. SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeleton. (PubMed id 12676785)1 Dyson J.M.... Mitchell C.A. (Blood 2003)
    452. Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)1 Salomon A.R.... Peters E.C. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    453. Stimulation of the alpha1A adrenergic receptor inhibits PDGF-induced PDGF beta receptor Tyr751 phosphorylation and PI 3-kinase activation. (PubMed id 12681492)1 Lin H.Y....Lin R.Z. (FEBS Lett. 2003)
    454. Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver. (PubMed id 12774026)1 Escribano O....Guijarro L.G. (Hepatology 2003)
    455. The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants. (PubMed id 12959980)1 D'Alessio A....de Franciscis V. (Endocrinology 2003)
    456. Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. (PubMed id 15747776)1 Sun N.N....Witten M.L. (Toxicol Ind Health 2003)
    457. Band 3 is an anchor protein and a target for SHP-2 tyrosine phosphatase in human erythrocytes. (PubMed id 12070037)1 Bordin L....Clari G. (Blood 2002)
    458. Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells. (PubMed id 12135708)1 Boudot C....Billat C. (Cell. Signal. 2002)
    459. Gab3, a new DOS/Gab family member, facilitates macrophage differentiation. (PubMed id 11739737)1 Wolf I....Rohrschneider L.R. (Mol. Cell. Biol. 2002)
    460. SPAP2, an Ig family receptor containing both ITIMs and ITAMs. (PubMed id 12051764)1 Xu M.-J.... Zhao Z.J. (Biochem. Biophys. Res. Commun. 2002)
    461. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    462. SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. (PubMed id 12270932)1 Wu T.R....Chin Y.E. (J. Biol. Chem. 2002)
    463. Clustering-induced signaling of CEACAM1 in PC12 cells. (PubMed id 12108545)1 Budt M....Lucka L. (Biol. Chem. 2002)
    464. The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities. (PubMed id 12237455)1 Espanel X....Hooft van Huijsduijnen R. (Protein Sci. 2002)
    465. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. (PubMed id 11743164)1 Higashi H....Hatakeyama M. (Science 2002)
    466. A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation. (PubMed id 12177051)1 Duchene J....Girolami J.P. (J. Biol. Chem. 2002)
    467. Cell surface glycoprotein PZR is a major mediator of concanavalin A- induced cell signaling. (PubMed id 11751924)1 Zhao R.... Zhao Z.J. (J. Biol. Chem. 2002)
    468. Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. (PubMed id 11940581)1 Saito Y....Berk B.C. (J. Biol. Chem. 2002)
    469. PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. (PubMed id 11782427)1 Lynch D.K. and Daly R.J. (EMBO J. 2002)
    470. NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked Lymphoproliferative disease. (PubMed id 11489943)1 Bottino C....Moretta A. (J. Exp. Med. 2001)
    471. Nerve growth factor activates persistent Rap1 signaling in endosomes. (PubMed id 11466412)1 Wu C....Mobley W.C. (J. Neurosci. 2001)
    472. Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. (PubMed id 11477068)1 Morra M.... Terhorst C. (J. Biol. Chem. 2001)
    473. Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system. (PubMed id 11432792)1 Yamada M....Hatanaka H. (J. Biochem. 2001)
    474. Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. (PubMed id 11353842)1 Ong S.H.... Lax I. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    475. Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT). (PubMed id 11491537)1 Huebener C.... Bruyns E. (Immunogenetics 2001)
    476. Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase. (PubMed id 11287610)1 Liu Y....Rohrschneider L.R. (Mol. Cell. Biol. 2001)
    477. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. (PubMed id 11689425)1 Morra M.... Terhorst C. (EMBO J. 2001)
    478. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. (PubMed id 11224527)1 Latchman Y.... Freeman G.J. (Nat. Immunol. 2001)
    479. Molecular cloning and characterization of SPAP1, an inhibitory receptor. (PubMed id 11162587)2 Xu M.-J.... Zhao Z.J. (Biochem. Biophys. Res. Commun. 2001)
    480. Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs. (PubMed id 11328818)1 Yu Z....Shen S.H. (J. Biol. Chem. 2001)
    481. Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation. (PubMed id 11714803)1 Kashiwada M.... Rothman P.B. (J. Immunol. 2001)
    482. Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways. (PubMed id 11447289)1 Hadari Y.R....Schlessinger J. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    483. Molecular events in transmembrane signaling via E-selectin. SHP2 association, adaptor protein complex formation and ERK1/2 activation. (PubMed id 11602579)1 Hu Y....Gimbrone M.A. (J. Biol. Chem. 2001)
    484. Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction. (PubMed id 11360177)1 Kurokawa K....Takahashi M. (Oncogene 2001)
    485. Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1. (PubMed id 11266449)1 Keilhack H.... Boehmer F.D. (J. Cell Biol. 2001)
    486. Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis. (PubMed id 10734310)1 Gual P....Comoglio P.M. (Oncogene 2000)
    487. SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone. (PubMed id 11036942)1 Carter-Su C....Stofega M.R. (Recent Prog. Horm. Res. 2000)
    488. PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif- bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. (PubMed id 10660620)1 Mousseau D.D.... Shen S.H. (J. Biol. Chem. 2000)
    489. Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B. (PubMed id 10976913)1 Stofega M.R....Carter-Su C. (Mol. Endocrinol. 2000)
    490. FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. (PubMed id 10903717)1 Fournier N....Garrone P. (J. Immunol. 2000)
    491. Tie-1 receptor tyrosine kinase endodomain interaction with SHP2: potential signalling mechanisms and roles in angiogenesis. (PubMed id 10949653)1 Marron M.B....Brindle N.P. (Adv. Exp. Med. Biol. 2000)
    492. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. (PubMed id 10871282)1 Schaeper U....Birchmeier W. (J. Cell Biol. 2000)
    493. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    494. Requirement for protein-tyrosine phosphatase SHP-2 in insulin-induced activation of c-Jun NH(2)-terminal kinase. (PubMed id 10671568)1 Fukunaga K....Kasuga M. (J. Biol. Chem. 2000)
    495. Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation. (PubMed id 10801826)1 Ilan N....Madri J.A. (J. Biol. Chem. 2000)
    496. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. (PubMed id 10790433)1 Brdicka T.... Schraven B. (J. Exp. Med. 2000)
    497. Recruitment of the protein-tyrosine phosphatase SHP-2 to the C-terminal tyrosine of the prolactin receptor and to the adaptor protein Gab2. (PubMed id 10991949)1 Ali S. and Ali S. (J. Biol. Chem. 2000)
    498. Syp Y279, Y304 Can Mediate the Binding of Bcr-Abl to Grb2 and Other Proteins. (PubMed id 12115002)1 Zhu K....Ye F.Y. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 1999)
    499. Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B. (PubMed id 9973385)1 Wang L.L....Yokoyama W.M. (J. Immunol. 1999)
    500. Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. (PubMed id 10082579)1 MaA+es S....MartA-nez-A C. (Mol. Cell. Biol. 1999)
    501. Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. (PubMed id 10022928)1 You M....Feng G.S. (Mol. Cell. Biol. 1999)
    502. Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. (PubMed id 10449753)1 Li C. and Friedman J.M. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    503. Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. (PubMed id 10521483)1 Jones N....Dumont D.J. (J. Biol. Chem. 1999)
    504. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. (PubMed id 10391903)1 Zhao C....Feng G.S. (J. Biol. Chem. 1999)
    505. Brain-derived neurotrophic factor enhances association of protein tyrosine phosphatase PTP1D with the NMDA receptor subunit NR2B in the cortical postsynaptic density. (PubMed id 10381539)1 Lin S.Y....Black I.B. (Brain Res. Mol. Brain Res. 1999)
    506. Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells. (PubMed id 10212213)1 Tang H....Inagami T. (J. Biol. Chem. 1999)
    507. Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. (PubMed id 10499918)1 Falco M.... Moretta A. (J. Exp. Med. 1999)
    508. Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins. (PubMed id 9632636)1 Moutoussamy S....Finidori J. (J. Biol. Chem. 1998)
    509. Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. (PubMed id 9485206)1 Le DrAcan E....Vivier E. (Eur. J. Immunol. 1998)
    510. Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor. (PubMed id 9824671)1 Ward A.C....Csar X.F. (Biochim. Biophys. Acta 1998)
    511. Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2. (PubMed id 9792637)1 Zhao Z.J. and Zhao R. (J. Biol. Chem. 1998)
    512. Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules. (PubMed id 9658397)1 Rocchi S....Van Obberghen E. (Mol. Endocrinol. 1998)
    513. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. (PubMed id 9285412)1 Meyaard L.... Phillips J.H. (Immunity 1997)
    514. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. (PubMed id 9405464)1 Kroll J. and Waltenberger J. (J. Biol. Chem. 1997)
    515. Transient association of the phosphotyrosine phosphatase SHP-2 with TrkA is induced by nerve growth factor. (PubMed id 9282923)1 Goldsmith B.A. and Koizumi S. (J. Neurochem. 1997)
    516. A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. (PubMed id 9029147)1 Abramovich C....Revel M. (EMBO J. 1997)
    517. Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2. (PubMed id 9188452)1 ManiAc S.N....Freedman A.S. (J. Biol. Chem. 1997)
    518. Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor. (PubMed id 9362449)1 Tang J....Li W. (Oncogene 1997)
    519. Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. (PubMed id 9388212)1 Kim H. and Baumann H. (J. Biol. Chem. 1997)
    520. Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and phosphatidylinositol 3-kinase with a 100-kDa tyrosine-phosphorylated protein in hemopoietic cells. (PubMed id 9361008)1 Craddock B.L. and Welham M.J. (J. Biol. Chem. 1997)
    521. Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells. (PubMed id 9344843)1 Chin H....Miura O. (Biochem. Biophys. Res. Commun. 1997)
    522. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (Genome Res. 1997)
    523. Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor. (PubMed id 9379041)1 Kimura T....Siraganian R.P. (J. Immunol. 1997)
    524. A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. (PubMed id 8943344)1 Fujioka Y....Kasuga M. (Mol. Cell. Biol. 1996)
    525. Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity. (PubMed id 8986614)1 Retta S.F....Tarone G. (Exp. Cell Res. 1996)
    526. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    527. Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein. (PubMed id 8662733)1 Fixman E.D....Park M. (J. Biol. Chem. 1996)
    528. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. (PubMed id 8638161)1 MarengA"re L.E....Mak T.W. (Science 1996)
    529. Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling. (PubMed id 8910607)1 Argetsinger L.S....Carter-Su C. (J. Biol. Chem. 1996)
    530. Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis. (PubMed id 8639815)1 Tauchi T....Krystal G. (Blood 1996)
    531. Structure and function of Cas-L, a 105-kD Crk-associated substrate- related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes. (PubMed id 8879209)1 Minegishi M.... Morimoto C. (J. Exp. Med. 1996)
    532. Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein. (PubMed id 7642582)1 Seely B.L....Olefsky J.M. (J. Biol. Chem. 1995)
    533. p125FAK tyrosine phosphorylation and focal adhesion assembly: studies with phosphotyrosine phosphatase inhibitors. (PubMed id 7589239)1 Defilippi P....Tarone G. (Exp. Cell Res. 1995)
    534. Protein-tyrosine phosphatase SH-PTP2 (PTPN11) is localized to 12q24.1-24.3. (PubMed id 8530013)1 Dechert U....Jirik F.R. (Hum. Genet. 1995)
    535. Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes. (PubMed id 7559603)1 Fuhrer D.K....Yang Y.C. (J. Biol. Chem. 1995)
    536. SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase. (PubMed id 8195176)1 Tauchi T....Broxmeyer H.E. (J. Biol. Chem. 1994)
    537. Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase. (PubMed id 8197172)1 Peraldi P....Van Obberghen E. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    538. The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. (PubMed id 7523381)1 Tauchi T....Broxmeyer H.E. (J. Biol. Chem. 1994)
    539. The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. (PubMed id 7688466)1 Kazlauskas A....Valius M. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    540. Noonan Syndrome (PubMed id 20301303)1 Pagon R.A....Stephens K. (1993)
    541. The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. (PubMed id 8505282)1 KuhnAc M.R....Feng G.S. (J. Biol. Chem. 1993)
    542. LEOPARD Syndrome (PubMed id 20301557)1 Pagon R.A....Stephens K. (1993)
    543. cDNA cloning of new protein tyrosine phosphatases in the human colon. (PubMed id 1626183)1 Arimura Y.... Yachi A. (Tumor Biol. 1992)
    544. Protein-tyrosine phosphatase expression in pre-B cell NALM-6. (PubMed id 1370651)1 Adachi M.... Yachi A. (Cancer Res. 1992)
    545. Regulation of the extent of splicing of influenza virus NS1 mRNA: role of the rates of splicing and of the nucleocytoplasmic transport of NS1 mRNA. (PubMed id 1824958)9 Alonso-Caplen F.V. and Krug R.M. (Mol. Cell. Biol. 1991)
    546. Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA. (PubMed id 1531330)9 Alonso-Caplen F.V....Krug R.M. (amp 1992)
    547. Characterization of a 115-kDa protein that binds to SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in Chinese hamster ovary cells. (PubMed id 8910355)9 Noguchi T....Kasuga M. (J. Biol. Chem. 1996)
    548. SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. (PubMed id 15040005)9 Ivins Zito C....Bennett A.M. (J. Cell. Physiol. 2004)
    549. Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors. (PubMed id 12923167)9 Araki T....Neel B.G. (J. Biol. Chem. 2003)
    550. Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein. (PubMed id 20133840)9 Hale B.G....Russell R.J. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    551. Activating PTPN11 mutations play a minor role in pediatric and adult solid tumors. (PubMed id 16631468)9 Martinelli S....Tartaglia M. (Cancer Genet. Cytogenet. 2006)
    552. Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. (PubMed id 15604238)9 Bentires-Alj M....Neel B.G. (Cancer Res. 2004)
    553. SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons. (PubMed id 12482708)9 Chen B....Bixby J.L. (Dev. Biol. 2002)
    554. The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors. (PubMed id 11593409)9 Wu C.J....Greene M.I. (Oncogene 2001)
    555. The NS1 protein of human respiratory syncytial virus is a potent inhibitor of minigenome transcription and RNA replication. (PubMed id 9445048)9 Atreya P.L....Collins P.L. (J. Virol. 1998)
    556. Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases. (PubMed id 9582366)9 Tsuda M....Kasuga M. (J. Biol. Chem. 1998)
    557. A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation. (PubMed id 9285826)9 Wright J.H....Krebs E.G. (Mol. Biol. Cell 1997)
    558. Interleukin-2 induces tyrosine phosphorylation of SHP-2 through IL-2 receptor beta chain. (PubMed id 9129156)9 Adachi M....Imai K. (Oncogene 1997)
    559. Expression of functional parvoviral NS1 from recombinant vaccinia virus: effects of mutations in the nucleotide-binding motif. (PubMed id 1413512)9 NA1esch J.P....Tattersall P. (Virology 1992)
    560. Protein tyrosine phosphatase SHP-2: a proto-oncogene product that promotes Ras activation. (PubMed id 19622105)9 Matozaki T....Ohnishi H. (Cancer Sci. 2009)
    561. SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl. (PubMed id 17003374)9 Chen J....Qu C.K. (Blood 2007)
    562. HSP70 binds to SHP2 and has effects on the SHP2-related EGFR/GAB1 signaling pathway. (PubMed id 17097051)9 Yoo J.C. and Hayman M.J. (Biochem. Biophys. Res. Commun. 2006)
    563. Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation. (PubMed id 14974085)9 Fragale A....Gelb B.D. (Hum. Mutat. 2004)
    564. Establishment of multifunctional monoclonal antibody to the nonstructural protein, NS1, of human parvovirus B19. (PubMed id 12963386)9 Chisaka H....Sugamura K. (J. Infect. 2003)
    565. Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts. (PubMed id 11997521)9 Kontaridis M.I....Bennett A.M. (Mol. Cell. Biol. 2002)
    566. Phosphorylation of the viral nonstructural protein NS1 during MVMp infection of A9 cells. (PubMed id 10388664)9 Corbau R....NA1esch J.P. (Virology 1999)
    567. Selective activation of SHP2 activity by cisplatin revealed by a novel chemical probe-based assay. (PubMed id 19909727)9 Kuo C.C....Lo L.C. (Biochem. Biophys. Res. Commun. 2010)
    568. The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cells. (PubMed id 19403682)9 Haye K....Fernandez-Sesma A. (J. Virol. 2009)
    569. Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells. (PubMed id 18421299)9 Zhou X.D. and Agazie Y.M. (Cell Death Differ. 2008)
    570. Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing. (PubMed id 18579758)9 Kakazu A....Bazan H.E. (amp 2008)
    571. SHP-2 is required for the maintenance of cardiac progenitors. (PubMed id 17928416)9 Langdon Y.G....Conlon F.L. (Development 2007)
    572. Annexin II binds to SHP2 and this interaction is regulated by HSP70 levels. (PubMed id 17395158)9 Yoo J.C. and Hayman M.J. (Biochem. Biophys. Res. Commun. 2007)
    573. The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor. (PubMed id 16573649)9 Easton J.B....Middlemas D.S. (J. Neurochem. 2006)
    574. Somatic PTPN11 mutations in childhood acute myeloid leukaemia. (PubMed id 15842656)9 Tartaglia M....Biondi A. (Br. J. Haematol. 2005)
    575. A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survival. (PubMed id 15116097)9 Chen J....Qu C.K. (Oncogene 2004)
    576. Human parvovirus B19 nonstructural protein (NS1) induces cell cycle arrest at G(1) phase. (PubMed id 12584315)9 Morita E....Sugamura K. (J. Virol. 2003)
    577. SH2 domain containing protein tyrosine phosphatase 2 regulates concanavalin A-dependent secretion and activation of matrix metalloproteinase 2 via the extracellular signal-regulated kinase and p38 pathways. (PubMed id 14559821)9 Ruhul Amin A.R....Hamaguchi M. (Cancer Res. 2003)
    578. Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif. (PubMed id 12535670)9 Gratzinger D....Madri J.A. (Biochem. Biophys. Res. Commun. 2003)
    579. The association between integrin-associated protein and SHPS-1 regulates insulin-like growth factor-I receptor signaling in vascular smooth muscle cells. (PubMed id 12972543)9 Maile L.A....Clemmons D.R. (Mol. Biol. Cell 2003)
    580. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2. (PubMed id 14652006)9 Gavrieli M.... Murphy K.M. (Biochem. Biophys. Res. Commun. 2003)
    581. The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation. (PubMed id 12011040)9 Huang Q....Abe J. (J. Biol. Chem. 2002)
    582. Regulation of insulin-like growth factor I receptor dephosphorylation by SHPS-1 and the tyrosine phosphatase SHP-2. (PubMed id 11779860)9 Maile L.A. and Clemmons D.R. (J. Biol. Chem. 2002)
    583. Divergent roles of SHP-2 in ERK activation by leptin receptors. (PubMed id 11085989)9 BjA...Flier J.S. (J. Biol. Chem. 2001)
    584. Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction. (PubMed id 9418864)9 O'Reilly A.M. and Neel B.G. (Mol. Cell. Biol. 1998)
    585. Identification of the major SHPTP2-binding protein that is tyrosine-phosphorylated in response to insulin. (PubMed id 7629070)9 Yamauchi K....Pessin J.E. (J. Biol. Chem. 1995)
    586. 2-Thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action. (PubMed id 18702480)9 Geronikaki A....Saxena A.K. (J. Med. Chem. 2008)
    587. The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury. (PubMed id 17647198)9 Chong Z.Z. and Maiese K. (Histol. Histopathol. 2007)
    588. SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. (PubMed id 17229738)9 Zito C.I....Bennett A.M. (J. Biol. Chem. 2007)
    589. [Overexpression of Shp-2 is associated with the unlimited growth and apoptosis resistance of p210 bcr-abl-mediated chronic myeloid leukemia]. (PubMed id 16255985)9 Zhu X.Z....Xu R.Z. (Zhonghua Yi Xue Za Zhi 2005)
    590. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. (PubMed id 15520383)9 Zhang E.E....Feng G.S. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    591. Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation. (PubMed id 12972574)9 Ferjoux G....Susini C. (Mol. Biol. Cell 2003)
    592. Regulation of the mitogen-activated protein kinase signaling pathway by SHP2. (PubMed id 11779868)9 Cunnick J.M....Wu J. (J. Biol. Chem. 2002)
    593. Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. (PubMed id 12149435)9 Geiss G.K....GarcA-a-Sastre A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    594. SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 are dramatically increased at the protein level in neutrophils from patients with severe congenital neutropenia (Kostmann's syndrome). (PubMed id 10378893)9 Tidow N....Welte K. (Exp. Hematol. 1999)
    595. Unique features of SHIP, SHP-1 and SHP-2 binding to FcgammaRIIb revealed by surface plasmon resonance analysis. (PubMed id 10397153)9 Famiglietti S.J....Cambier J.C. (Immunol. Lett. 1999)
    596. B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation. (PubMed id 9670943)9 Nakamura K. and Cambier J.C. (J. Immunol. 1998)
    597. Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association. (PubMed id 9507023)9 Stofega M.R....Carter-Su C. (J. Biol. Chem. 1998)
    598. A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation. (PubMed id 9642214)9 Deb T.B....Johnson G.R. (J. Biol. Chem. 1998)
    599. Epidermal growth factor downregulates the expression of SH-PTP2. (PubMed id 9852290)9 Kamer A.R....Liebow C. (Int. J. Mol. Med. 1998)
    600. The cytotoxicity of the parvovirus minute virus of mice nonstructural protein NS1 is related to changes in the synthesis and phosphorylation of cell proteins. (PubMed id 9151861)9 Anouja F....Caillet-Fauquet P. (J. Virol. 1997)
    601. Localization and down-regulating role of the protein tyrosine phosphatase PTP2C in membrane ruffles of PDGF-stimulated cells. (PubMed id 8601424)9 Cossette L.J....Shen S.H. (Exp. Cell Res. 1996)
    602. A cytotoxic nonstructural protein, NS1, of human parvovirus B19 induces activation of interleukin-6 gene expression. (PubMed id 8970971)9 Moffatt S....Sugamura K. (J. Virol. 1996)
    603. Altered expression of protein-tyrosine phosphatase 2C in 293 cells affects protein tyrosine phosphorylation and mitogen-activated protein kinase activation. (PubMed id 7744825)9 Zhao Z....Fischer E.H. (J. Biol. Chem. 1995)
    604. Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling. (PubMed id 16461457)9 UhlAcn P....Bennett A.M. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    605. Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2. (PubMed id 12593670)9 Fairlie W.D....Baca M. (Biochem. J. 2003)
    606. A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling. (PubMed id 12483539)9 Ruhul Amin A.R....Hamaguchi M. (Oncogene 2002)
    607. A functional nuclear localization sequence in the C-terminal domain of SHP-1. (PubMed id 11323437)9 Craggs G. and Kellie S. (J. Biol. Chem. 2001)
    608. The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism. (PubMed id 10208413)9 Walter A.O....Cartwright C.A. (Oncogene 1999)
    609. Epidermal growth factor-induced association of the SHPTP2 protein tyrosine phosphatase with a 115-kDa phosphotyrosine protein. (PubMed id 7541031)9 Yamauchi K. and Pessin J.E. (J. Biol. Chem. 1995)
    610. PTPN11 mutation associated with aortic dilation and hypertrophic cardiomyopathy in a pediatric patient with Noonan syndrome. (PubMed id 19795160)9 Jefferies J.L....Craigen W.J. (Pediatr Cardiol 2010)
    611. Cell surface expression of channel catfish leukocyte immune-type receptors (IpLITRs) and recruitment of both Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 and SHP-2. (PubMed id 19013191)9 Montgomery B.C....Stafford J.L. (Dev. Comp. Immunol. 2009)
    612. A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis. (PubMed id 19359598)9 Wang D....Rao G.N. (Circ. Res. 2009)
    613. Cation currents in human airway epithelial cells induced by infection with influenza A virus. (PubMed id 19403603)9 Gallacher M....Wilson S.M. (J. Physiol. (Lond.) 2009)
    614. Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells. (PubMed id 17984366)9 Sampaio W.O....Touyz R.M. (Hypertension 2007)
    615. Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations. (PubMed id 17268534)9 Metzner A....JA1cker M. (Gene Ther. 2007)
    616. Severe aortic valvar stenosis in familial Noonan syndrome with mutation of the PTPN11 gene. (PubMed id 17184563)9 Abadir S....Julia S. (Cardiol Young 2007)
    617. [Expression of tyrosine phosphatase containing C-src homology SH-2 in benign prostate hyperplasia]. (PubMed id 17924469)9 Peng M.F. and Shen J.G. (Zhejiang Da Xue Xue Bao Yi Xue Ban 2007)
    618. [Genetic analysis of NS1 fragment of human H5N1 influenza virus isolated in Anhui province and its expression in Escherichia coli]. (PubMed id 17672298)9 Cheng C.S....Shu Y.L. (Wei Sheng Wu Xue Bao 2007)
    619. Ligation of CD28 stimulates the formation of a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the gab2 pleckstrin homology domain. (PubMed id 16365455)9 Parry R.V....Ward S.G. (J. Immunol. 2006)
    620. Enhanced sensitivity to inhibition of SHP2, STAT5, and Gab2 expression in chronic myeloid leukemia (CML). (PubMed id 16278304)9 Scherr M....Eder M. (Blood 2006)
    621. Modeling regulatory mechanisms in IL-6 signal transduction in hepatocytes. (PubMed id 16752369)9 Singh A....Hahn J. (Biotechnol. Bioeng. 2006)
    622. A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. (PubMed id 16611743)9 Wang C.Z....Tang M.J. (Mol. Biol. Cell 2006)
    623. Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases. (PubMed id 16481357)9 Jarvis L.A....Smith-Bolton R.K. (Development 2006)
    624. Interaction between insulin-like growth factor-I receptor and alphaVbeta3 integrin linked signaling pathways: cellular responses to changes in multiple signaling inputs. (PubMed id 15528274)9 Clemmons D.R. and Maile L.A. (Mol. Endocrinol. 2005)
    625. Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223. (PubMed id 16020478)9 Luo M....Mandarino L.J. (Endocrinology 2005)
    626. The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling. (PubMed id 15683731)9 Clahsen T....Schaper F. (Cell. Signal. 2005)
    627. SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively. (PubMed id 16260787)9 Yuan L....Qu C.K. (J. Biol. Chem. 2005)
    628. The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes. (PubMed id 15115663)9 Incoronato M....de Franciscis V. (Cell. Signal. 2004)
    629. Signal transduction of c-Kit receptor tyrosine kinase in CHRF myeloid leukemia cells. (PubMed id 15340843)9 Scholl S....Klinger R. (J. Cancer Res. Clin. Oncol. 2004)
    630. Chicken Ig-like receptor B2, a member of a multigene family, is mainly expressed on B lymphocytes, recruits both Src homology 2 domain containing protein tyrosine phosphatase (SHP)-1 and SHP-2, and inhibits proliferation. (PubMed id 15585863)9 Viertlboeck B.C....GAPbel T.W. (J. Immunol. 2004)
    631. Role of the CD47-SHPS-1 system in regulation of cell migration. (PubMed id 12773380)9 Motegi S....Matozaki T. (EMBO J. 2003)
    632. Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes. (PubMed id 12855672)9 Nakaoka Y....Hirota H. (Circ. Res. 2003)
    633. The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells. (PubMed id 12925139)9 Azuma T....Hatakeyama M. (amp 2003)
    634. Identification of Shp-2 as a Stat5A phosphatase. (PubMed id 12615921)9 Chen Y....Wang D. (J. Biol. Chem. 2003)
    635. Modulation of insulin-stimulated glycogen synthesis by Src Homology Phosphatase 2. (PubMed id 11325523)9 Ouwens D.M....Maassen J.A. (Mol. Cell. Endocrinol. 2001)
    636. Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1. (PubMed id 11564708)9 Hennige A.M....Kellerer M. (Endocrinology 2001)
    637. CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A. (PubMed id 11313386)9 Shlapatska L.M.... Sidorenko S.P. (J. Immunol. 2001)
    638. Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha. (PubMed id 10842184)9 Stofega M.R.... Carter-Su C. (J. Biol. Chem. 2000)
    639. Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2. (PubMed id 10887109)9 Paul S.P....McVicar D.W. (Blood 2000)
    640. The mitogen-activated protein (MAP) kinase p38 and its upstream activator MAP kinase kinase 6 are involved in the activation of signal transducer and activator of transcription by hyperosmolarity. (PubMed id 10514514)9 Bode J.G....Graeve L. (J. Biol. Chem. 1999)
    641. SHP-2, SH2-containing protein tyrosine phosphatase-2. (PubMed id 9693956)9 Stein-Gerlach M....Ullrich A. (amp 1998)
    642. Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase. (PubMed id 9632795)9 Takahashi-Tezuka M....Hirano T. (Mol. Cell. Biol. 1998)
    643. Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression. (PubMed id 9794795)9 Schaper F....Heinrich P.C. (Biochem. J. 1998)
    644. Dominant negative variants of the SHP-2 tyrosine phosphatase inhibit prolactin activation of Jak2 (janus kinase 2) and induction of Stat5 (signal transducer and activator of transcription 5)-dependent transcription. (PubMed id 9544991)9 Berchtold S....Groner B. (Mol. Endocrinol. 1998)
    645. The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors. (PubMed id 9393882)9 Sattler M....Griffin J.D. (Oncogene 1997)
    646. The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression. (PubMed id 9285712)9 Symes A....Fink J.S. (Curr. Biol. 1997)
    647. SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells. (PubMed id 9299490)9 Ong S.H....Guy G.R. (Biochem. Biophys. Res. Commun. 1997)
    648. Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs. (PubMed id 9295037)9 VAcly F....Vivier E. (Eur. J. Immunol. 1997)
    649. Involvement of Src-homology-2-domain-containing protein-tyrosine phosphatase 2 in T cell activation. (PubMed id 8647120)9 Tailor P....Mustelin T. (Eur. J. Biochem. 1996)
    650. Interaction cloning of NS1-I, a human protein that binds to the nonstructural NS1 proteins of influenza A and B viruses. (PubMed id 8764047)9 Wolff T....Palese P. (J. Virol. 1996)
    651. Expression of dominant negative mutant SHPTP2 attenuates phosphatidylinositol 3'-kinase activity via modulation of phosphorylation of insulin receptor substrate-1. (PubMed id 8647870)9 Ugi S....Kikkawa R. (J. Biol. Chem. 1996)
    652. Protein-tyrosine phosphatase 1D modulates its own state of tyrosine phosphorylation. (PubMed id 7559570)9 Stein-Gerlach M....Ullrich A. (J. Biol. Chem. 1995)
    653. Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2. (PubMed id 8226787)9 Sugimoto S....Walsh C.T. (J. Biol. Chem. 1993)
    654. Through its nonstructural protein NS1, parvovirus H-1 induces apoptosis via accumulation of reactive oxygen species. (PubMed id 20375165)9 Hristov G....Marchini A. (J. Virol. 2010)
    655. Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells. (PubMed id 20207740)9 Radhakrishnan Y....Clemmons D.R. (J. Biol. Chem. 2010)
    656. The tyrosine phosphatase Shp2 in development and cancer. (PubMed id 20399956)9 Grossmann K.S....Birchmeier W. (Adv. Cancer Res. 2010)
    657. Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells. (PubMed id 19299420)9 Shen X....Clemmons D.R. (amp 2009)
    658. Cutting edge: stealth influenza virus replication precedes the initiation of adaptive immunity. (PubMed id 19717515)9 Moltedo B....Moran T.M. (J. Immunol. 2009)
    659. The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways. (PubMed id 19706713)9 Billharz R....Katze M.G. (J. Virol. 2009)
    660. Development of a live-attenuated influenza B DeltaNS1 intranasal vaccine candidate. (PubMed id 19366569)9 Wressnigg N....Kittel C. (Vaccine 2009)
    661. Molecular characterization of a balanced rearrangement of chromosome 12 in two siblings with Noonan syndrome. (PubMed id 19938085)9 Yatsenko S.A....Bacino C.A. (Am. J. Med. Genet. A 2009)
    662. Somatostatin receptors 1 and 5 heterodimerize with epidermal growth factor receptor: agonist-dependent modulation of the downstream MAPK signalling pathway in breast cancer cells. (PubMed id 19070659)9 Watt H.L....Kumar U. (Cell. Signal. 2009)
    663. Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. (PubMed id 19948503)9 MA1ller M.M....Obrink B. (J. Cell Biol. 2009)
    664. ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2. (PubMed id 17947393)9 Walter R.B....Cooper J.A. (J. Leukoc. Biol. 2008)
    665. Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin. (PubMed id 19047464)9 Lee S.H....Reichardt L.F. (J. Cell Biol. 2008)
    666. Noonan and cardio-facio-cutaneous syndromes: two clinically and genetically overlapping disorders. (PubMed id 18456719)9 NystrAPm A.M....Bondeson M.L. (J. Med. Genet. 2008)
    667. Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages. (PubMed id 18233962)9 Miyake A....Matozaki T. (amp 2008)
    668. Clinical and molecular characterization of 40 patients with Noonan syndrome. (PubMed id 18678287)9 Ferrero G.B....Silengo M.C. (Eur J Med Genet 2008)
    669. Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay. (PubMed id 19007293)9 Yu W.M....Qu C.K. (J. Med. Chem. 2008)
    670. NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I. (PubMed id 17053203)9 Guo Z....Sambhara S. (Am. J. Respir. Cell Mol. Biol. 2007)
    671. Therapy-related acute myeloid leukemia in a child with Noonan syndrome and clonal duplication of the germline PTPN11 mutation. (PubMed id 16078230)9 Chantrain C.F....Brichard B. (amp 2007)
    672. A novel VIP signaling pathway in T cells cAMP--&gt;protein tyrosine phosphatase (SHP-2?)--&gt;JAK2/STAT4--&gt;Th1 differentiation. (PubMed id 17462790)9 Liu L....Ganea D. (Peptides 2007)
    673. The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration. (PubMed id 17483340)9 Voena C....Chiarle R. (Cancer Res. 2007)
    674. Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparan sulfate and chondroitin sulfate E. (PubMed id 18052531)9 Avirutnan P....Diamond M.S. (PLoS Pathog. 2007)
    675. Shp2 is involved in neuronal differentiation of hippocampal precursor cells. (PubMed id 17679554)9 Kim H.J....Kwon Y.K. (Arch. Pharm. Res. 2007)
    676. The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor. (PubMed id 17027227)9 Godeny M.D....Sayeski P.P. (Cell. Signal. 2007)
    677. Influenza virus NS1 protein protects against lymphohematopoietic pathogenesis in an in vivo mouse model. (PubMed id 16545418)9 Hyland L....Hou S. (Virology 2006)
    678. Aortic root dilatation is a rare complication of Noonan syndrome. (PubMed id 16830086)9 Power P.D....Glass I.A. (Pediatr Cardiol 2006)
    679. Prostate tumor cells infected with a recombinant influenza virus expressing a truncated NS1 protein activate cytolytic CD8+ cells to recognize noninfected tumor cells. (PubMed id 16352563)9 Efferson C.L....Ioannides C.G. (J. Virol. 2006)
    680. Shp2 as a therapeutic target for leptin resistance and obesity. (PubMed id 16441233)9 Feng G.S. (Expert Opin. Ther. Targets 2006)
    681. Silencing of SH-PTP2 defines a crucial role in the inactivation of epidermal growth factor receptor by 5-aminosalicylic acid in colon cancer cells. (PubMed id 16082388)9 Monteleone G....Pallone F. (Cell Death Differ. 2006)
    682. Tumor necrosis factor inhibits growth hormone-mediated gene expression in hepatocytes. (PubMed id 16574984)9 Ahmed T....Cooney R.N. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006)
    683. Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. (PubMed id 15738000)9 Harada A....Negishi M. (J. Biol. Chem. 2005)
    684. Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis. (PubMed id 16367902)9 Hatakeyama M. and Higashi H. (Cancer Sci. 2005)
    685. Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. (PubMed id 14963045)9 Higashi H....Hatakeyama M. (J. Biol. Chem. 2004)
    686. SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. (PubMed id 15240681)9 Chemnitz J.M....Riley J.L. (J. Immunol. 2004)
    687. Interferon resistance promotes oncolysis by influenza virus NS1-deletion mutants. (PubMed id 15054864)9 Muster T....Bergmann M. (Int. J. Cancer 2004)
    688. Deferential regulation of placenta growth factor (PlGF)-mediated signal transduction in human primary term trophoblast and endothelial cells. (PubMed id 15081632)9 Arroyo J....Torry D.S. (Placenta 2004)
    689. The influenza B virus nonstructural NS1 protein is essential for efficient viral growth and antagonizes beta interferon induction. (PubMed id 14747551)9 Dauber B....Wolff T. (J. Virol. 2004)
    690. MADS-box protein complexes control carpel and ovule development in Arabidopsis. (PubMed id 14555696)9 Favaro R....Colombo L. (Plant Cell 2003)
    691. Vanadate regulates the insulin mitogenic effect by modulating SHP-2 association with insulin receptor substrate 1 in JAr human choriocarcinoma cells. (PubMed id 12857432)9 Bifulco G....Nappi C. (Gynecol. Endocrinol. 2003)
    692. Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation. (PubMed id 12947019)9 Lerner-Marmarosh N....Abe J. (Arterioscler. Thromb. Vasc. Biol. 2003)
    693. Integrin-associated protein binding domain of thrombospondin-1 enhances insulin-like growth factor-I receptor signaling in vascular smooth muscle cells. (PubMed id 14563713)9 Maile L.A. and Clemmons D.R. (Circ. Res. 2003)
    694. Chemical dissection of the effects of tyrosine phosphorylation of SHP-2. (PubMed id 12731888)9 Lu W....Cole P.A. (Biochemistry 2003)
    695. Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2. (PubMed id 12024020)9 Zhang S.Q....Neel B.G. (Mol. Cell. Biol. 2002)
    696. A role for Grb2-associated binder-1 in growth hormone signaling. (PubMed id 12446613)9 Kim S.O....Frank S.J. (Endocrinology 2002)
    697. Angiotensin II activation of the JAK/STAT pathway in mesangial cells is altered by high glucose. (PubMed id 11967010)9 Amiri F....Marrero M.B. (Kidney Int. 2002)
    698. Minute virus of mice NS1 interacts with the SMN protein, and they colocalize in novel nuclear bodies induced by parvovirus infection. (PubMed id 11907229)9 Young P.J....Lorson C.L. (J. Virol. 2002)
    699. Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain. (PubMed id 12204103)9 Kruse S....Deichmann K.A. (Respir. Res. 2002)
    700. Substrate specificity of protein tyrosine phosphatase: differential behavior of SHP-1 and SHP-2 towards signal regulation protein SIRPalpha1. (PubMed id 11835408)9 Mishra A.K....Zhou G.W. (J. Cell. Biochem. 2002)
    701. Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2. (PubMed id 11830491)9 Dorsey J.F....Wu J. (Blood 2002)
    702. Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a. (PubMed id 11340297)9 Brockdorff J.L....A9dum N. (Exp. Clin. Immunogenet. 2001)
    703. Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited. (PubMed id 11737194)9 Friederichs K....Schaper F. (Eur. J. Biochem. 2001)
    704. Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. (PubMed id 11544330)9 Pathak M.K. and Yi T. (J. Immunol. 2001)
    705. Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma. (PubMed id 11593406)9 Hideshima T....Anderson K.C. (Oncogene 2001)
    706. Src homology 2 domain-containing protein-tyrosine phosphatases, SHP-1 and SHP-2, are required for platelet endothelial cell adhesion molecule-1/CD31-mediated inhibitory signaling. (PubMed id 11207261)9 Henshall T.L....Jackson D.E. (J. Immunol. 2001)
    707. Construction and expression of an enzymatically active form of PECAM-1 containing the phosphatase domain of the protein tyrosine phosphatase, SHP-2. (PubMed id 11388808)9 Noda M....Newman P.J. (Protein Expr. Purif. 2001)
    708. Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling. (PubMed id 11684012)9 Lu W....Cole P.A. (Mol. Cell 2001)
    709. Biliary glycoprotein (BGPa, CD66a, CEACAM1) mediates inhibitory signals. (PubMed id 11493628)9 Chen T....Bolland S. (J. Leukoc. Biol. 2001)
    710. Signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. (PubMed id 10604985)9 Dietrich J.... Colonna M. (J. Immunol. 2000)
    711. Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction. (PubMed id 10781410)9 Tamir I....Cambier J.C. (Curr. Opin. Immunol. 2000)
    712. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. (PubMed id 10661409)9 Ohtani T....Hirano T. (Immunity 2000)
    713. Src homology domain 2-containing tyrosine phosphatase 2 associates with intercellular adhesion molecule 1 to regulate cell survival. (PubMed id 10864922)9 Pluskota E....D'Souza S.E. (J. Biol. Chem. 2000)
    714. Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase. (PubMed id 11027663)9 Zhang S. and Broxmeyer H.E. (Biochem. Biophys. Res. Commun. 2000)
    715. Cooperation between SHP-2, phosphatidyl inositol 3-kinase and phosphoinositol 5-phosphatase in the Fc gamma RIIb mediated B cell regulation. (PubMed id 10397152)9 SA!rmay G....Gergely J. (Immunol. Lett. 1999)
    716. SOCS-1, -2, -3: selective targets and functions downstream of the prolactin receptor. (PubMed id 10630404)9 Tomic S....Ali S. (Mol. Cell. Endocrinol. 1999)
    717. Tyrosine phosphatase SHP-2 dephosphorylates the platelet-derived growth factor receptor but enhances its downstream signalling. (PubMed id 9931295)9 Zhao R. and Zhao Z.J. (Biochem. J. 1999)
    718. Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. (PubMed id 10325410)9 Falcon A.M.... Ortin J. (Nucleic Acids Res. 1999)
    719. Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. (PubMed id 10358138)9 Tangye S.G....Phillips J.H. (J. Immunol. 1999)
    720. Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma. (PubMed id 10463951)9 Olivera A....Spiegel S. (FASEB J. 1999)
    721. Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal. (PubMed id 9547347)9 Maeda A....Kurosaki T. (J. Exp. Med. 1998)
    722. Regulation of angiotensin II-induced JAK2 tyrosine phosphorylation: roles of SHP-1 and SHP-2. (PubMed id 9814969)9 Marrero M.B....Venema R.C. (Am. J. Physiol. 1998)
    723. Opposite regulation of tyrosine-phosphorylation of p130(Cas) by insulin and insulin-like growth factor I. (PubMed id 9832615)9 Fujita T....Kikkawa R. (J. Biochem. 1998)
    724. Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules. (PubMed id 9722576)9 Ito N.... Claesson-Welsh L. (J. Biol. Chem. 1998)
    725. Differential expression of SHP2, a protein-tyrosine phosphatase with SRC homology-2 domains, in various types of renal tumour. (PubMed id 9808435)9 Kuroda N....Itoh H. (Virchows Arch. 1998)
    726. Epidermal growth factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2, a SH2 domain-containing protein tyrosine phosphatase. (PubMed id 9344856)9 Ochi F....Kasuga M. (Biochem. Biophys. Res. Commun. 1997)
    727. Regulation of PTP1D mRNA by peptide growth factors in the human endometrial cell line HEC-1-A. (PubMed id 9408887)9 Burke J.J....Menon K.M. (J. Soc. Gynecol. Investig. 1997)
    728. The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: potential implications in haemorrhagic fever pathogenesis. (PubMed id 9191856)9 Falconar A.K. (Arch. Virol. 1997)
    729. Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway. (PubMed id 9054456)9 Yu Z....Shen S.H. (J. Biol. Chem. 1997)
    730. Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells. (PubMed id 9815779)9 Ogata A....Anderson K.C. (Clin. Cancer Res. 1997)
    731. Signaling functions of the tyrosine residues in the betac chain of the granulocyte-macrophage colony-stimulating factor receptor. (PubMed id 9389692)9 Okuda K....Foster R. (Blood 1997)
    732. Both SH2 domains are involved in interaction of SHP-1 with the epidermal growth factor receptor but cannot confer receptor-directed activity to SHP-1/SHP-2 chimera. (PubMed id 9038217)9 Tenev T....BAPhmer F.D. (J. Biol. Chem. 1997)
    733. Beta 1 integrin-mediated signaling in human T cells. (PubMed id 9183644)9 Morimoto C. and Tachibana K. (Hum. Cell 1996)
    734. The SH2 domain-containing tyrosine phosphatase PTP1D is required for interferon alpha/beta-induced gene expression. (PubMed id 8663536)9 David M....Larner A.C. (J. Biol. Chem. 1996)
    735. Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. (PubMed id 7531337)9 Yamauchi K....Pessin J.E. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    736. Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. (PubMed id 7513703)9 Sugimoto S....Walsh C.T. (J. Biol. Chem. 1994)
    737. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. (PubMed id 7504175)9 Sun X.J....White M.F. (Mol. Cell. Biol. 1993)
    738. Production of dimer-specific and dengue virus group cross-reactive mouse monoclonal antibodies to the dengue 2 virus non-structural glycoprotein NS1. (PubMed id 1849979)9 Falconar A.K. and Young P.R. (J. Gen. Virol. 1991)
    739. Evolution of the NS genes of the influenza A viruses. II. Characteristics of the amino acid changes in the NS1 proteins of the influenza A viruses. (PubMed id 2144065)9 Nakajima K....Nakajima S. (Virus Genes 1990)
    740. Study of anti-dengue NS1 antibody by western blot. (PubMed id 2149144)9 Kuno G....GA^mez I. (J. Med. Virol. 1990)
    741. Highly pathogenic avian influenza A virus H5N1 NS1 protein induces caspase-dependent apoptosis in human alveolar basal epithelial cells. (PubMed id 20196872)9 Zhang C....Huang P. (Virol. J. 2010)
    742. Src tyrosine kinase preactivation is associated with platelet hypersensitivity in essential thrombocythemia and polycythemia vera. (PubMed id 19965650)9 Randi M.L....Donella-Deana A. (Blood 2010)
    743. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. (PubMed id 20053498)9 Li F....Sethi G. (Cancer Lett. 2010)
    744. Hemophagocytosis associated with leukemia: a striking association with juvenile myelomonocytic leukemia. (PubMed id 19798502)9 Unal S....Gurgey A. (Ann. Hematol. 2010)
    745. Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation. (PubMed id 20052757)9 Kobayashi T....Matsubara Y. (Hum. Mutat. 2010)
    746. Noonan syndrome, the SOS1 gene and embryonal rhabdomyosarcoma. (PubMed id 20461756)9 Jongmans M.C....Hoogerbrugge N. (amp 2010)
    747. Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. (PubMed id 20215346)9 Pan Y....Zhang X. (Development 2010)
    748. Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation. (PubMed id 20082303)9 Jung J.H....Kim H.S. (J. Cell. Physiol. 2010)
    749. Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells. (PubMed id 20235152)9 Saydmohammed M....Syed V. (J. Cell. Biochem. 2010)
    750. Tumor spectrum in children with Noonan syndrome and SOS1 or RAF1 mutations. (PubMed id 19953625)9 Denayer E....Legius E. (Genes Chromosomes Cancer 2010)
    751. Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. (PubMed id 20133777)9 Zhao Y....Wang Z. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    752. Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells. (PubMed id 20348091)9 Lee I.O....Lee Y.C. (J. Biol. Chem. 2010)
    753. Enhancement of insulin responsiveness by nitric oxide-mediated inactivation of protein-tyrosine phosphatases. (PubMed id 20064934)9 Hsu M.F. and Meng T.C. (J. Biol. Chem. 2010)
    754. Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia. (PubMed id 20008299)9 Muramatsu H....Maciejewski J.P. (Blood 2010)
    755. Prenatal detection of Noonan syndrome by mutation analysis of the PTPN11 and the KRAS genes. (PubMed id 20112233)9 Houweling A.C....Go A.T. (Prenat. Diagn. 2010)
    756. Giant cell lesions in noonan syndrome: case report and review of the literature. (PubMed id 20383758)9 Bufalino A....Coletta R.D. (Head Neck Pathol 2010)
    757. Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells. (PubMed id 20471511)9 Larsson N....Fioretos T. (Cancer Genet. Cytogenet. 2010)
    758. Dual action of epidermal growth factor: extracellular signal-stimulated nuclear-cytoplasmic export and coordinated translation of selected messenger RNA. (PubMed id 20142421)9 Tsai N.P....Wei L.N. (J. Cell Biol. 2010)
    759. Protein tyrosine phosphatases in glioma biology. (PubMed id 19936768)9 Navis A.C....Hendriks W.J. (Acta Neuropathol. 2010)
    760. Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infections. (PubMed id 20526368)9 Oberbach A....Neuhaus J. (PLoS ONE 2010)
    761. Juvenile myelomonocytic leukemia with PTPN11 mutation in a 23-month-old girl. (PubMed id 20432758)9 JakovljeviA8 G....NakiA8 M. (Coll Antropol 2010)
    762. Functions and molecular mechanisms of the CD47-SIRPalpha signalling pathway. (PubMed id 19144521)9 Matozaki T....Ohnishi H. (Trends Cell Biol. 2009)
    763. Multiple giant cell lesions in patients with Noonan syndrome and cardio-facio-cutaneous syndrome. (PubMed id 18854871)9 Neumann T.E....Kalscheuer V. (Eur. J. Hum. Genet. 2009)
    764. Enhancement of oncolytic properties of recombinant newcastle disease virus through antagonism of cellular innate immune responses. (PubMed id 19209145)9 Zamarin D....Fong Y. (Mol. Ther. 2009)
    765. Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development. (PubMed id 18849586)9 Oishi K....Gelb B.D. (Hum. Mol. Genet. 2009)
    766. Neuronal guidance protein Netrin-1 induces differentiation in human embryonal carcinoma cells. (PubMed id 19223540)9 Mancino M....Strizzi L. (Cancer Res. 2009)
    767. CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. (PubMed id 19065049)9 Park Y.M....Silverstein R.L. (J. Clin. Invest. 2009)
    768. Anti-dengue virus nonstructural protein 1 antibodies recognize protein disulfide isomerase on platelets and inhibit platelet aggregation. (PubMed id 19822367)9 Cheng H.J....Lin Y.S. (Mol. Immunol. 2009)
    769. Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation. (PubMed id 19056487)9 Boyle K....Robb L. (Cell. Signal. 2009)
    770. CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215. (PubMed id 19007960)9 Hale B.G....Randall R.E. (Virology 2009)
    771. Coronary artery dilatation in LEOPARD syndrome. A child case and literature review. (PubMed id 19207402)9 Iwasaki Y....Matsuoka R. (Congenit Heart Dis 2009)
    772. Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. (PubMed id 19001090)9 Princen F....Feng G.S. (Mol. Cell. Biol. 2009)
    773. IMAGE CARDIO MED. A patient with LEOPARD syndrome and PTPN11 mutation. (PubMed id 19273734)9 Lehmann L.H....Katus H.A. (Circulation 2009)
    774. Cytokine signalling via gp130 in gastric cancer. (PubMed id 19665497)9 Howlett M....Giraud A.S. (Biochim. Biophys. Acta 2009)
    775. Grb2 associated binder 2 couples B-cell receptor to cell survival. (PubMed id 18950707)9 Maus M....SA!rmay G. (Cell. Signal. 2009)
    776. Role of tyrosine phosphatase inhibitors in cancer treatment with emphasis on SH2 domain-containing tyrosine phosphatases (SHPs). (PubMed id 19199865)9 Irandoust M....Cloos J. (Anticancer Agents Med Chem 2009)
    777. The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit. (PubMed id 19049823)9 Pedersen M....Sun J. (Cell. Signal. 2009)
    778. SHP-2 tyrosine phosphatase in human diseases. (PubMed id 19436828)9 Zheng H....Qu C.K. (Int J Clin Exp Med 2009)
    779. &quot;Shping 2&quot; different cellular localizations - a potential new player in aging processes. (PubMed id 20157547)9 Jakob S....Haendeler J. (Aging (Albany NY) 2009)
    780. Detection of dengue nonstructural 1 (NS1) protein in Vietnamese patients with fever. (PubMed id 19232866)9 Phuong H.L....de Vries P.J. (Diagn. Microbiol. Infect. Dis. 2009)
    781. Response to growth hormone in short children with Noonan syndrome: correlation to genotype. (PubMed id 20029239)9 Binder G. (Horm. Res. 2009)
    782. SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels. (PubMed id 19290938)9 Lorenz U. (Immunol. Rev. 2009)
    783. Noonan syndrome caused by germline KRAS mutation in Taiwan: report of two patients and a review of the literature. (PubMed id 18958496)9 Lo F.S....Lin S.P. (Eur. J. Pediatr. 2009)
    784. New, exciting developments in experimental therapies in the early 21st century. (PubMed id 19825369)9 Los M. (Eur. J. Pharmacol. 2009)
    785. Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo. (PubMed id 19139110)9 Burger R....Anderson K.C. (Mol. Cancer Ther. 2009)
    786. Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia. (PubMed id 18927438)9 Kearney L....Greaves M. (Blood 2009)
    787. Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060. (PubMed id 19782562)9 Seo C....Ahn J.S. (amp 2009)
    788. PTPN11 analysis for the prenatal diagnosis of Noonan syndrome in fetuses with abnormal ultrasound findings. (PubMed id 18759865)9 Lee K.A....Kornreich R. (Clin. Genet. 2009)
    789. A novel PTPN11 missense mutation in a patient with LEOPARD syndrome. (PubMed id 19659470)9 Osawa R....Shimizu H. (Br. J. Dermatol. 2009)
    790. Chlorella powder inhibits the activities of peptidase cathepsin S, PLA2, cyclooxygenase-2, thromboxane synthase, tyrosine phosphatases, tumor necrosis factor-alpha converting enzyme, calpain and kinases. (PubMed id 19107625)9 Cheng F.C....Shimoda M. (Int J Food Sci Nutr 2009)
    791. The tyrosine kinase network regulating mast cell activation. (PubMed id 19290926)9 Gilfillan A.M. and Rivera J. (Immunol. Rev. 2009)
    792. Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development. (PubMed id 19541608)9 Nakamura T....Robbins J. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    793. Noonan syndrome, the Ras-MAPK signalling pathway and short stature. (PubMed id 19407499)9 Binder G. (Horm. Res. 2009)
    794. Proteins selectively killing tumor cells. (PubMed id 19836376)9 Noteborn M.H. (Eur. J. Pharmacol. 2009)
    795. Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells. (PubMed id 19665053)9 Fukumoto T....Tanaka T. (Cell. Signal. 2009)
    796. Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells. (PubMed id 19233262)9 Caron C....Royal I. (Cell. Signal. 2009)
    797. Urotensin II induces transactivation of the epidermal growth factor receptor via transient oxidation of SHP-2 in the rat renal tubular cell line NRK-52E. (PubMed id 19326266)9 Sue Y.M....Chen T.H. (Growth Factors 2009)
    798. Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11. (PubMed id 19054014)9 Schrader K.A....McGillivray B.C. (Clin. Genet. 2009)
    799. The functional impairment of natural killer cells during influenza virus infection. (PubMed id 19721456)9 Guo H....Malarkannan S. (Immunol. Cell Biol. 2009)
    800. Abnormal growth in noonan syndrome: the challenge of optimal therapy. (PubMed id 19550387)9 Savage M.O....Jorge A.A. (Pediatr Endocrinol Rev 2009)
    801. Malignant diseases in Noonan syndrome and related disorders. (PubMed id 20029231)9 Hasle H. (Horm. Res. 2009)
    802. Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2. (PubMed id 19821497)9 Blechacz B.R....Gores G.J. (Hepatology 2009)
    803. Genetic evaluation and management of fetal chylothorax: review and insights from a case of Noonan syndrome. (PubMed id 19927903)9 Chen C.H....Chen M. (Lymphology 2009)
    804. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. (PubMed id 19571318)9 Loh M.L....Niemeyer C.M. (Blood 2009)
    805. Analysis of influenza B Virus NS1 protein trafficking reveals a novel interaction with nuclear speckle domains. (PubMed id 18987144)9 Schneider J....Wolff T. (J. Virol. 2009)
    806. Deletion of the C-terminal region of dengue virus nonstructural protein 1 (NS1) abolishes anti-NS1-mediated platelet dysfunction and bleeding tendency. (PubMed id 19592650)9 Chen M.C....Lin Y.S. (J. Immunol. 2009)
    807. Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis. (PubMed id 19179468)9 Chan G....Neel B.G. (Blood 2009)
    808. Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus. (PubMed id 19386707)9 Richards K.A....Sant A.J. (J. Virol. 2009)
    809. O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs. (PubMed id 19671924)9 Klein A.L....Ball L.E. (amp 2009)
    810. G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation. (PubMed id 18644434)9 Wang L....Robinson L.J. (Cell. Signal. 2008)
    811. [SOS1 mutation: a new cause of Noonan syndrome]. (PubMed id 18394382)9 Serrano-MartA-n M.M....LA^pez-Siguero J.P. (An Pediatr (Barc) 2008)
    812. Common acute lymphoblastic leukemia in a girl with genetically confirmed LEOPARD syndrome. (PubMed id 18799937)9 Laux D....Sauerbrey A. (J. Pediatr. Hematol. Oncol. 2008)
    813. The proteosomal degradation of fusion proteins cannot be predicted from the proteosome susceptibility of their individual components. (PubMed id 18411420)9 Ilyinskii P.O....Shneider A.M. (Protein Sci. 2008)
    814. Visual function in Noonan and LEOPARD syndrome. (PubMed id 19568997)9 Alfieri P....Mercuri E. (Neuropediatrics 2008)
    815. Discovery of novel non-peptide thrombopoietin mimetic compounds that induce megakaryocytopoiesis. (PubMed id 18620546)9 Yamane N....Takemoto H. (Biosci. Rep. 2008)
    816. TGF-beta inhibits IL-2 production and promotes cell cycle arrest in TCR-activated effector/memory T cells in the presence of sustained TCR signal transduction. (PubMed id 18209044)9 Das L. and Levine A.D. (J. Immunol. 2008)
    817. Clonogenic assay of type a influenza viruses reveals noninfectious cell-killing (apoptosis-inducing) particles. (PubMed id 18184709)9 Ngunjiri J.M....Marcus P.I. (J. Virol. 2008)
    818. Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling. (PubMed id 18165234)9 Heikkinen L.S....Saksela K. (J. Biol. Chem. 2008)
    819. Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration. (PubMed id 18645011)9 Zou G.M. and Maitra A. (Mol. Cancer Ther. 2008)
    820. Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. (PubMed id 18680359)9 Lawrence H.R....Lawrence N.J. (J. Med. Chem. 2008)
    821. A2 isoform of mammalian translation factor eEF1A displays increased tyrosine phosphorylation and ability to interact with different signalling molecules. (PubMed id 17936057)9 Panasyuk G....El'skaya A.V. (amp 2008)
    822. Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. (PubMed id 18480264)9 Hellmuth K....Birchmeier W. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    823. Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species. (PubMed id 18070887)9 BAoumer A.T....Rosenkranz S. (J. Biol. Chem. 2008)
    824. p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 membrane recruitment. (PubMed id 18606861)9 Xi G....Clemmons D.R. (Mol. Endocrinol. 2008)
    825. Comparison of hypoplastic myelodysplastic syndrome (MDS) with normo-/hypercellular MDS by International Prognostic Scoring System, cytogenetic and genetic studies. (PubMed id 18094713)9 Huang T.C....Tien H.F. (Leukemia 2008)
    826. Development of an allele-specific minimal residual disease assay for patients with juvenile myelomonocytic leukemia. (PubMed id 18000165)9 Archambeault S....Loh M.L. (Blood 2008)
    827. Tyrosine phosphorylation of netrin receptors in netrin-1 signaling. (PubMed id 18253061)9 Ren X.R....Xiong W.C. (Neurosignals 2008)
    828. The tyrosine phosphatase Shp2 (PTPN11) in cancer. (PubMed id 18286234)9 Chan G....Neel B.G. (Cancer Metastasis Rev. 2008)
    829. hCEACAM1-4L downregulates hDAF-associated signalling after being recognized by the Dr adhesin of diffusely adhering Escherichia coli. (PubMed id 17979980)9 Rougeaux C....Servin A.L. (Cell. Microbiol. 2008)
    830. Recent advances in the pathogenesis and management of juvenile myelomonocytic leukaemia. (PubMed id 18422786)9 Koike K. and Matsuda K. (Br. J. Haematol. 2008)
    831. Activation of c-Src and Fyn kinases by protein-tyrosine phosphatase RPTPalpha is substrate-specific and compatible with lipid raft localization. (PubMed id 18948260)9 Vacaresse N....Sap J. (J. Biol. Chem. 2008)
    832. Liver injury caused by antibodies against dengue virus nonstructural protein 1 in a murine model. (PubMed id 18679379)9 Lin C.F....Lin Y.S. ( a journal of technical methods and pathology 2008)
    833. Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells. (PubMed id 18292389)9 Cavet M.E....Berk B.C. (Arterioscler. Thromb. Vasc. Biol. 2008)
    834. Genome wide analysis of pathogenic SH2 domain mutations. (PubMed id 18260110)9 Lappalainen I....Vihinen M. (Proteins 2008)
    835. The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway. (PubMed id 17993263)9 Dance M....Raynal P. (Cell. Signal. 2008)
    836. Targeting PTPs with small molecule inhibitors in cancer treatment. (PubMed id 18259840)9 Jiang Z.X. and Zhang Z.Y. (Cancer Metastasis Rev. 2008)
    837. Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. (PubMed id 18192401)9 Ohnishi N....Hatakeyama M. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    838. G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2. (PubMed id 18955485)9 Mori J....Watson S.P. (J. Biol. Chem. 2008)
    839. Human parvovirus B19 NS1 protein modulates inflammatory signaling by activation of STAT3/PIAS3 in human endothelial cells. (PubMed id 18550668)9 Duechting A....Bock C.T. (J. Virol. 2008)
    840. Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia. (PubMed id 18701506)9 Case M....Irving J.A. (Cancer Res. 2008)
    841. SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients. (PubMed id 18064648)9 Swanson K.D....Neel B.G. (amp 2008)
    842. Aqueous extract of Arbutus unedo inhibits STAT1 activation in human breast cancer cell line MDA-MB-231 and human fibroblasts through SHP2 activation. (PubMed id 18473914)9 Mariotto S....Suzuki H. (Med Chem 2008)
    843. Adenovirus-based vaccines generate cytotoxic T lymphocytes to epitopes of NS1 from dengue virus that are present in all major serotypes. (PubMed id 18788905)9 Gao G....Wilson J.M. (Hum. Gene Ther. 2008)
    844. Germline PTPN11 missense mutation in a case of Noonan syndrome associated with mediastinal and retroperitoneal neuroblastic tumors. (PubMed id 18328949)9 Mutesa L....Bours V. (Cancer Genet. Cytogenet. 2008)
    845. Clinical manifestations in patients with SOS1 mutations range from Noonan syndrome to CFC syndrome. (PubMed id 18651097)9 Narumi Y....Matsubara Y. (J. Hum. Genet. 2008)
    846. Modulation of bone marrow-derived endothelial progenitor cell activity by protein tyrosine phosphatases. (PubMed id 18790388)9 Trop S....Bourdeau A. (Trends Cardiovasc. Med. 2008)
    847. A mass action model of a Fibroblast Growth Factor signaling pathway and its simplification. (PubMed id 18841420)9 Gaffney E.A....Kwiatkowska M.Z. (Bull. Math. Biol. 2008)
    848. Studies of the mechanism of selectivity of protein tyrosine phosphatase 1B (PTP1B) bidentate inhibitors using molecular dynamics simulations and free energy calculations. (PubMed id 18831546)9 Fang L....Ji M. (J Chem Inf Model 2008)
    849. Hepatoblastoma in a Noonan syndrome patient with a PTPN11 mutation. (PubMed id 18253957)9 Yoshida R....Nagai T. (amp 2008)
    850. Docking of oxalyl aryl amino benzoic acid derivatives into PTP1B. (PubMed id 19238234)9 Verma N....Verma R.K. (Bioinformation 2008)
    851. Granular cell tumor of the scrotum in a child with Noonan syndrome. (PubMed id 18577039)9 Sidwell R.U....Green J.S. (Pediatr Dermatol 2008)
    852. Constitutive activation of SHP2 protein tyrosine phosphatase inhibits ICSBP-induced transcription of the gene encoding gp91PHOX during myeloid differentiation. (PubMed id 18089853)9 Zhu C....Eklund E.A. (J. Leukoc. Biol. 2008)
    853. [Noonan syndrome: from phenotype to growth hormone therapy]. (PubMed id 18797587)9 Malaquias A.C....Jorge A.A. (Arq Bras Endocrinol Metabol 2008)
    854. The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders. (PubMed id 18470943)9 Aoki Y....Matsubara Y. (Hum. Mutat. 2008)
    855. Abnormal growth in noonan syndrome: genetic and endocrine features and optimal treatment. (PubMed id 18663312)9 Padidela R....Savage M.O. (Horm. Res. 2008)
    856. Avian influenza virus A/HK/483/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells. (PubMed id 18199656)9 Lam W.Y....Chan P.K. (J. Virol. 2008)
    857. Respiratory syncytial virus (RSV) attachment and nonstructural proteins modify the type I interferon response associated with suppressor of cytokine signaling (SOCS) proteins and IFN-stimulated gene-15 (ISG15). (PubMed id 18851747)9 Moore E.C....Tripp R.A. (Virol. J. 2008)
    858. A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor. (PubMed id 18180305)9 Ha C.H....Jin Z.G. (J. Biol. Chem. 2008)
    859. Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration. (PubMed id 18482983)9 Mathew S....Khurana S. (J. Biol. Chem. 2008)
    860. Somatostatin/somatostatin receptor signalling: phosphotyrosine phosphatases. (PubMed id 17913342)9 Florio T. (Mol. Cell. Endocrinol. 2008)
    861. The effect of transforming growth factor beta on human neuroendocrine tumor BON cell proliferation and differentiation is mediated through somatostatin signaling. (PubMed id 18567806)9 Leu F.P....Niu C. (Mol. Cancer Res. 2008)
    862. CEACAM1 dynamics during neisseria gonorrhoeae suppression of CD4+ T lymphocyte activation. (PubMed id 18453603)9 Lee H.S....Gray-Owen S.D. (J. Immunol. 2008)
    863. Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress. (PubMed id 17412627)9 Clemmons D.R....Busby W.H. (amp 2007)
    864. Shp2 in PC12 cells: NGF versus EGF signalling. (PubMed id 17287109)9 D'Alessio A....de Franciscis V. (Cell. Signal. 2007)
    865. Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. (PubMed id 17056636)9 Zenker M.... Kutsche K. (J. Med. Genet. 2007)
    866. Germline gain-of-function mutations in RAF1 cause Noonan syndrome. (PubMed id 17603482)9 Razzaque M.A.... Matsuoka R. (Nat. Genet. 2007)
    867. Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. (PubMed id 17646384)9 Ke Y....Feng G.S. (Mol. Cell. Biol. 2007)
    868. Inhibition of a specific N-glycosylation activity results in attenuation of breast carcinoma cell invasiveness-related phenotypes: inhibition of epidermal growth factor-induced dephosphorylation of focal adhesion kinase. (PubMed id 17537730)9 Guo H.B....Pierce M. (J. Biol. Chem. 2007)
    869. Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression. (PubMed id 17724739)9 Jackson C.B....Giraud A.S. (J. Pathol. 2007)
    870. Homology modeling and examination of the effect of the D92E mutation on the H5N1 nonstructural protein NS1 effector domain. (PubMed id 17917748)9 Li M. and Wang B. (J Mol Model 2007)
    871. PECAM-1 ligation negatively regulates TLR4 signaling in macrophages. (PubMed id 18025177)9 Rui Y....Wang J. (J. Immunol. 2007)
    872. Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome. (PubMed id 17704260)9 Nava C....CavAc H. (J. Med. Genet. 2007)
    873. Defining SH2 domain and PTP specificity by screening combinatorial peptide libraries. (PubMed id 17532507)9 Wavreille A.S....Pei D. (Methods 2007)
    874. Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft. (PubMed id 17378938)9 Guvench O....MacKerell A.D. (BMC Struct. Biol. 2007)
    875. Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer. (PubMed id 17568183)9 Katoh M. (amp 2007)
    876. Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. (PubMed id 17143282)9 Tartaglia M.... Gelb B.D. (Nat. Genet. 2007)
    877. Antibody responses are generated to immunodominant ELK/KLE-type motifs on the nonstructural-1 glycoprotein during live dengue virus infections in mice and humans: implications for diagnosis, pathogenesis, and vaccine design. (PubMed id 17329445)9 Falconar A.K. (Clin. Vaccine Immunol. 2007)
    878. SOS1 is the second most common Noonan gene but plays no major role in cardio-facio-cutaneous syndrome. (PubMed id 17586837)9 Zenker M....Kutsche K. (J. Med. Genet. 2007)
    879. SHP-1 tyrosine phosphatase in human erythrocytes. (PubMed id 17404032)9 Bragadin M....Bordin L. (Ann. N. Y. Acad. Sci. 2007)
    880. Malignant melanoma in a woman with LEOPARD syndrome: identification of a germline PTPN11 mutation and a somatic BRAF mutation. (PubMed id 17927788)9 Seishima M....Ogata T. (Br. J. Dermatol. 2007)
    881. Excellent growth response to growth hormone therapy in a child with PTPN11-negative Noonan syndrome and features of growth hormone resistance. (PubMed id 17598979)9 Walton-Betancourth S....Savage M.O. (J. Endocrinol. Invest. 2007)
    882. Molecular and clinical characterization of cardio-facio-cutaneous (CFC) syndrome: overlapping clinical manifestations with Costello syndrome. (PubMed id 17366577)9 Narumi Y....Matsubara Y. (Am. J. Med. Genet. A 2007)
    883. A complex karyotype, including a three-way translocation generating a NUP98-HOXD13 transcript, in an infant with acute myeloid leukemia. (PubMed id 17656257)9 Hidaka E....Koike K. (Cancer Genet. Cytogenet. 2007)
    884. Leukemia in Cardio-facio-cutaneous (CFC) syndrome: a patient with a germline mutation in BRAF proto-oncogene. (PubMed id 17483702)9 Makita Y....Aoki Y. (J. Pediatr. Hematol. Oncol. 2007)
    885. Comparison between molecularly defined and conventional therapeutics in a conditional BCR-ABL cell culture model. (PubMed id 17461760)9 Chaturvedi A....Scherr M. (Oligonucleotides 2007)
    886. The role of Shp2 (PTPN11) in cancer. (PubMed id 17227708)9 Mohi M.G. and Neel B.G. (amp 2007)
    887. Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency. (PubMed id 17703371)9 Aeby A....Van Bogaert P. (J. Inherit. Metab. Dis. 2007)
    888. Respiratory failure, juvenile myelomonocytic leukemia, and neonatal Noonan syndrome. (PubMed id 17414570)9 Cheong J.L. and Moorkamp M.H. (J. Pediatr. Hematol. Oncol. 2007)
    889. Vanadate-induced inhibition of BCR-triggered apoptosis is coupled with tyrosine phosphorylation and induction of G2M growth arrest in Ramos-BL B cells. (PubMed id 17558712)9 Hristov K.K....Mitev V.I. (Immunol. Invest. 2007)
    890. Shp2, a novel oncogenic tyrosine phosphatase and potential therapeutic target for human leukemia. (PubMed id 17404595)9 Xu R. (Cell Res. 2007)
    891. LEOPARD syndrome with partly normal skin and sex chromosome mosaicism. (PubMed id 17935252)9 Writzl K....Hennekam R.C. (Am. J. Med. Genet. A 2007)
    892. Neurons or glia? Can SHP2 know it all? (PubMed id 17971566)9 Coskun V....Sun Y.E. (Sci. STKE 2007)
    893. Grb2-associated binder-1 plays a central role in the hepatocyte growth factor enhancement of hepatoma growth inhibition by K vitamin analog compound 5. (PubMed id 18046719)9 Wang Z....Carr B.I. (Hepatology 2007)
    894. The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. (PubMed id 17982034)9 Michalek R.D....Grayson J.M. (J. Immunol. 2007)
    895. Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2: implications for cellular morphology. (PubMed id 17971444)9 Nakata S....Takai Y. (J. Biol. Chem. 2007)
    896. An unexpected new role of mutant Ras: perturbation of human embryonic development. (PubMed id 17211612)9 Kratz C.P....Zenker M. (J. Mol. Med. 2007)
    897. Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11. (PubMed id 17353900)9 Flotho C....Niemeyer C.M. (Oncogene 2007)
    898. Mutation analysis of the genes involved in the Ras-mitogen-activated protein kinase (MAPK) pathway in Korean patients with Noonan syndrome. (PubMed id 17661820)9 Lee S.T....Lee H.J. (Clin. Genet. 2007)
    899. The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro. (PubMed id 17311996)9 Newland S.A.... Campbell D.R. (Blood 2007)
    900. Cross-inhibition of interferon-induced signals by GM-CSF through a block in Stat1 activation. (PubMed id 18052729)9 Kasper S....Fischer T. (amp 2007)
    901. Neurofibromatosis presenting with a cherubism phenotype. (PubMed id 17120035)9 van Capelle C.I....Flanagan A.M. (Eur. J. Pediatr. 2007)
    902. Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma. (PubMed id 17712732)9 Janzarik W.G....Omran H. (Neuropediatrics 2007)
    903. The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation. (PubMed id 17178724)9 LaramAce M....Royal I. (J. Biol. Chem. 2007)
    904. Clonal duplication of a germline PTPN11 mutation due to acquired uniparental disomy in acute lymphoblastic leukemia blasts from a patient with Noonan syndrome. (PubMed id 17361219)9 Karow A....Kratz C.P. (Leukemia 2007)
    905. Analyzing protein tyrosine phosphatases by phosphotyrosine analog integration. (PubMed id 17532510)9 Shen K. (Methods 2007)
    906. The genetics of congenital heart disease: a review of recent developments. (PubMed id 17413276)9 Weismann C.G. and Gelb B.D. (Curr. Opin. Cardiol. 2007)
    907. Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN. (PubMed id 17926183)9 Fridberg M....Wingren A.G. (amp 2007)
    908. Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling. (PubMed id 17063460)9 Moyers J.S....Kharitonenkov A. (J. Cell. Physiol. 2007)
    909. The RNA binding domain of influenza A virus NS1 protein affects secretion of tumor necrosis factor alpha, interleukin-6, and interferon in primary murine tracheal epithelial cells. (PubMed id 17596305)9 Newby C.M....Pekosz A. (J. Virol. 2007)
    910. Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. (PubMed id 17603483)9 Pandit B.... Gelb B.D. (Nat. Genet. 2007)
    911. The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation. (PubMed id 17440960)9 Roubelakis M.G....Watt S.M. (J. Cell. Biochem. 2007)
    912. Lethal proliferation of erythroid precursors in a neonate with a germline PTPN11 mutation. (PubMed id 16369799)9 Kratz C.P....Niemeyer C.M. (Eur. J. Pediatr. 2006)
    913. Does the rare A172G mutation of PTPN11 gene convey a mild Noonan syndrome phenotype? (PubMed id 16804314)9 Kitsiou-Tzeli S....Nicolaidou P. (Horm. Res. 2006)
    914. Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. (PubMed id 16809424)9 NAPren-MA1ller A....Waldmann H. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    915. Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. (PubMed id 16474404)9 Niihori T.... Matsubara Y. (Nat. Genet. 2006)
    916. The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils. (PubMed id 16254138)9 Munitz A....Levi-Schaffer F. (Blood 2006)
    917. Noonan syndrome and related disorders: alterations in growth and puberty. (PubMed id 17177115)9 Noonan J.A. (amp 2006)
    918. Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. (PubMed id 16253990)9 Brummer T....Daly R.J. (J. Biol. Chem. 2006)
    919. Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. (PubMed id 16773572)9 Carta C.... Tartaglia M. (Am. J. Hum. Genet. 2006)
    920. The cardiofaciocutaneous syndrome. (PubMed id 16825433)9 Roberts A....Neri G. (J. Med. Genet. 2006)
    921. PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases. (PubMed id 17141222)9 Vantler M....Rosenkranz S. (FEBS Lett. 2006)
    922. Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation. (PubMed id 16414009)9 Li Z....Miyagawa K. (Biochem. Biophys. Res. Commun. 2006)
    923. Mutation analysis of PTPN11 in Noonan syndrome by WAVE. (PubMed id 16930008)9 Elanko N. and Jeffery S. (Methods Mol. Med. 2006)
    924. Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal. (PubMed id 16939816)9 Chan R.J....Yoder M.C. (Exp. Hematol. 2006)
    925. SHP-2-Erk signaling regulates concanavalin A-dependent production of TIMP-2. (PubMed id 16904070)9 Biswas M.H....Hamaguchi M. (Biochem. Biophys. Res. Commun. 2006)
    926. Secretion of flaviviral non-structural protein NS1: from diagnosis to pathogenesis. (PubMed id 17319166)9 Alcon-LePoder S....Flamand M. (Novartis Found. Symp. 2006)
    927. Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1. (PubMed id 16638574)9 Hanna N....Raynal P. (FEBS Lett. 2006)
    928. Double-stranded RNA binding of influenza B virus nonstructural NS1 protein inhibits protein kinase R but is not essential to antagonize production of alpha/beta interferon. (PubMed id 16987984)9 Dauber B....Wolff T. (J. Virol. 2006)
    929. [Expression of host genes in influenza virus infected cells]. (PubMed id 17037354)9 Shimizu K. and Kuroda K. (Nippon Rinsho 2006)
    930. Increased expression and secretion of interleukin-6 in human parvovirus B19 non-structural protein (NS1) transfected COS-7 epithelial cells. (PubMed id 16542377)9 Hsu T.C....Tsay G.J. (Clin. Exp. Immunol. 2006)
    931. Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction. (PubMed id 16987887)9 Gelb B.D. and Tartaglia M. (Hum. Mol. Genet. 2006)
    932. Design and functional activity of phosphopeptides with potential immunomodulating capacity, based on the sequence of Grb2-associated binder 1. (PubMed id 17341634)9 Kertesz A....Sarmay G. (Ann. N. Y. Acad. Sci. 2006)
    933. Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin. (PubMed id 16840725)9 Corbacioglu S....Debatin K.M. (Blood 2006)
    934. Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3. (PubMed id 16697063)9 Dixon S.J....Meakin S.O. (Biochim. Biophys. Acta 2006)
    935. Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3. (PubMed id 16767162)9 Burks J. and Agazie Y.M. (Oncogene 2006)
    936. SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. (PubMed id 17157040)9 An H....Cao X. (Immunity 2006)
    937. Mutation of Thr466 in SHP2 abolishes its phosphatase activity, but provides a new substrate-trapping mutant. (PubMed id 16413071)9 Merritt R....Agazie Y.M. (Biochim. Biophys. Acta 2006)
    938. PTPN11 gene mutations: linking the Gln510Glu mutation to the &quot;LEOPARD syndrome phenotype&quot;. (PubMed id 16733669)9 Digilio M.C....Dallapiccola B. (Eur. J. Pediatr. 2006)
    939. Csk homologous kinase (CHK), unlike Csk, enhances MAPK activation via Ras-mediated signaling in a Src-independent manner. (PubMed id 16168623)9 Zagozdzon R....Avraham H.K. (Cell. Signal. 2006)
    940. B and T lymphocyte attenuator-mediated signal transduction provides a potent inhibitory signal to primary human CD4 T cells that can be initiated by multiple phosphotyrosine motifs. (PubMed id 16709818)9 Chemnitz J.M....Riley J.L. (J. Immunol. 2006)
    941. The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation. (PubMed id 16406061)9 Isnardi I....DaAron M. (Immunol. Lett. 2006)
    942. Shp2 is dispensable in the formation and maintenance of the neuromuscular junction. (PubMed id 16837792)9 Dong X.P....Mei L. (Neurosignals 2006-2007)
    943. Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement. (PubMed id 16544248)9 Avirutnan P....Malasit P. (J. Infect. Dis. 2006)
    944. The pleckstrin homology domain of Gab-2 is required for optimal interleukin-3 signalsome-mediated responses. (PubMed id 16275030)9 Edmead C.E....Welham M.J. (Cell. Signal. 2006)
    945. Cellular functions of vaults and their involvement in multidrug resistance. (PubMed id 16918321)9 Steiner E....Berger W. (Curr Drug Targets 2006)
    946. Establishment of functional B cell memory against parvovirus B19 capsid proteins may be associated with resolution of persistent infection. (PubMed id 16299723)9 Corcoran A....Doyle S. (J. Med. Virol. 2006)
    947. Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts. (PubMed id 16765027)9 Duan H.F....Wang L.S. (Cell. Signal. 2006)
    948. Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations. (PubMed id 16467864)9 Niimi H....Kimura A. (Leukemia 2006)
    949. Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways. (PubMed id 16702953)9 Huang L....Tsuchida N. (Oncogene 2006)
    950. Noonan syndrome: relationships between genotype, growth, and growth factors. (PubMed id 16263833)9 Limal J.M....Le Bouc Y. (J. Clin. Endocrinol. Metab. 2006)
    951. Translational inhibition and increased interferon induction in cells infected with C protein-deficient measles virus. (PubMed id 16987969)9 Nakatsu Y....Yanagi Y. (J. Virol. 2006)
    952. The cell-adhesion and signaling molecule PECAM-1 is a molecular mediator of resistance to genotoxic chemotherapy. (PubMed id 17106245)9 Bergom C....Newman P.J. (amp 2006)
    953. Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. (PubMed id 16399795)9 Oishi K....Gelb B.D. (Hum. Mol. Genet. 2006)
    954. Occupation of alphavbeta3-integrin by endogenous ligands modulates IGF-I receptor activation and proliferation of human intestinal smooth muscle. (PubMed id 16195423)9 Kuemmerle J.F. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006)
    955. Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position. (PubMed id 16702225)9 Imhof D....Pei D. (J. Biol. Chem. 2006)
    956. Protein-tyrosine phosphatases and cancer. (PubMed id 16557282)9 Ostman A....BAPhmer F.D. (Nat. Rev. Cancer 2006)
    957. Protection against dengue type 2 virus induced in mice immunized with a DNA plasmid encoding the non-structural 1 (NS1) gene fused to the tissue plasminogen activator signal sequence. (PubMed id 16122850)9 Costa S.M....Alves A.M. (Vaccine 2006)
    958. Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth. (PubMed id 17158954)9 Bertotti A....Trusolino L. (J. Cell Biol. 2006)
    959. Is sudden cardiac death predictable in LEOPARD syndrome? (PubMed id 17116277)9 Limongelli G....CalabrA^ R. (Cardiol Young 2006)
    960. Cooperation of activating Ras/rtk signal transduction pathway mutations and inactivating myeloid differentiation gene mutations in M0 AML: a study of 45 patients. (PubMed id 16424869)9 Roumier C....Preudhomme C. (Leukemia 2006)
    961. PECAM-1 isoform-specific activation of MAPK/ERKs and small GTPases: implications in inflammation and angiogenesis. (PubMed id 16440301)9 Wang Y. and Sheibani N. (J. Cell. Biochem. 2006)
    962. Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling. (PubMed id 16371368)9 Yu W.M....Qu C.K. (J. Biol. Chem. 2006)
    963. A SHPing tale: perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail. (PubMed id 16084691)9 Poole A.W. and Jones M.L. (Cell. Signal. 2005)
    964. Little response to zoledronic acid in a child of juvenile myelomonocytic leukemia (JMML) harboring the PTPN11 mutation. (PubMed id 15857842)9 Shimada H....Takahashi T. (Ann. Oncol. 2005)
    965. Direct protein-protein interaction between PLCgamma1 and the bradykinin B2 receptor--importance of growth conditions. (PubMed id 15607753)9 Duchene J....Schanstra J.P. (Biochem. Biophys. Res. Commun. 2005)
    966. Acute myeloid leukemia in an adult Noonan syndrome patient with PTPN11 mutation. (PubMed id 15929108)9 Matsubara K....Fukaya T. (Am. J. Hematol. 2005)
    967. Platelet-derived growth factor receptor-beta (PDGFR-beta) activation promotes its association with the low density lipoprotein receptor-related protein (LRP). Evidence for co-receptor function. (PubMed id 15944146)9 Newton C.S....Strickland D.K. (J. Biol. Chem. 2005)
    968. Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation. (PubMed id 15882975)9 Pai R....Tarnawski A. (Biochem. Biophys. Res. Commun. 2005)
    969. PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion. (PubMed id 16278812)9 Saunders P.A....Woods M.L. (Eur. J. Immunol. 2005)
    970. Neisseria gonorrhoeae kills carcinoembryonic antigen-related cellular adhesion molecule 1 (CD66a)-expressing human B cells and inhibits antibody production. (PubMed id 15972507)9 Pantelic M....Chen T. (Infect. Immun. 2005)
    971. Alternative mode of binding to phosphotyrosyl peptides by Src homology-2 domains. (PubMed id 16142918)9 Qin C....Pei D. (Biochemistry 2005)
    972. Hyperthrophic cardiomyopathy and the PTPN11 gene. (PubMed id 15937948)9 Sarkozy A....Tartaglia M. (Am. J. Med. Genet. A 2005)
    973. [SHP2 and MKP5 in P2Y purinergic receptor-mediated prostate cancer invasion]. (PubMed id 16181551)9 He H.Y....Fang W.G. (Zhonghua Bing Li Xue Za Zhi 2005)
    974. Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation. (PubMed id 15684422)9 Barrett D.M....Mikkelsen R.B. (J. Biol. Chem. 2005)
    975. Noonan syndrome mutation Q79R in Shp2 increases proliferation of valve primordia mesenchymal cells via extracellular signal-regulated kinase 1/2 signaling. (PubMed id 16166557)9 Krenz M....Robbins J. (Circ. Res. 2005)
    976. FLT3/ITD mutation signaling includes suppression of SHP-1. (PubMed id 15574429)9 Chen P....Small D. (J. Biol. Chem. 2005)
    977. Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis. (PubMed id 16012947)9 Han X....Denson L.A. (Gastroenterology 2005)
    978. Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells. (PubMed id 15761018)9 Schubbert S....Shannon K.M. (Blood 2005)
    979. Regulation of cys-based protein tyrosine phosphatases via reactive oxygen and nitrogen species in mast cells and basophils. (PubMed id 16101506)9 Heneberg P. and DrA!ber P. (Curr. Med. Chem. 2005)
    980. Expression of cytokine, chemokine, and adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1. (PubMed id 15611263)9 Lin C.F....Lin Y.S. (J. Immunol. 2005)
    981. Generation of an influenza A virus vector expressing biologically active human interleukin-2 from the NS gene segment. (PubMed id 16051859)9 Kittel C....Egorov A. (J. Virol. 2005)
    982. Investigation of protein-tyrosine phosphatases by in-gel assays. (PubMed id 15588982)9 Markova B....BAPhmer F.D. (Methods 2005)
    983. A new PTPN11 mutation in juvenile myelomonocytic leukaemia associated with Noonan syndrome. (PubMed id 16188759)9 Giovannini L....Sirvent N. (Acta Paediatr. 2005)
    984. Effects on synaptic activity in cultured hippocampal neurons by influenza A viral proteins. (PubMed id 16162482)9 Brask J....Kristensson K. (J. Neurovirol. 2005)
    985. Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is important. (PubMed id 15640155)9 Vantler M....Rosenkranz S. (J. Biol. Chem. 2005)
    986. Noonan-like syndrome mutations in PTPN11 in patients diagnosed with cherubism. (PubMed id 15996221)9 Jafarov T....Reichenberger E. (Clin. Genet. 2005)
    987. RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251. (PubMed id 15611085)9 Kiely P.A....O'Connor R. (J. Biol. Chem. 2005)
    988. Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP. (PubMed id 15933714)9 Kwon J....Williams M.S. (EMBO J. 2005)
    989. Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity. (PubMed id 15650750)9 Rusanescu G....Feig L.A. (EMBO J. 2005)
    990. Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1beta and 18. (PubMed id 15604446)9 Stasakova J....Egorov A. (J. Gen. Virol. 2005)
    991. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. (PubMed id 16055727)9 Alblas J....van den Berg T.K. (Mol. Cell. Biol. 2005)
    992. A novel mutation in the PTPN11 gene in a patient with Noonan syndrome and rapidly progressive hypertrophic cardiomyopathy. (PubMed id 15889278)9 Takahashi K....Ozono K. (Eur. J. Pediatr. 2005)
    993. Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. (PubMed id 15769739)9 Avril T....Crocker P.R. (J. Biol. Chem. 2005)
    994. Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains. (PubMed id 16274240)9 Sweeney M.C....Pei D. (Biochemistry 2005)
    995. Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NF-kappaB, and proinflammatory cytokines. (PubMed id 15827150)9 Spann K.M....Collins P.L. (J. Virol. 2005)
    996. Cytoskeletal remodeling in vascular smooth muscle cells in response to angiotensin II-induced activation of the SHP-2 tyrosine phosphatase. (PubMed id 16021628)9 Fernstrom K....Ali M.S. (J. Cell. Physiol. 2005)
    997. [PTPN11 gene mutation in LEOPARD syndrome]. (PubMed id 16172598)9 Paradisi M....Angelo C. (Minerva Pediatr. 2005)
    998. The role of CD150-SH2D1A association in CD150 signaling in Hodgkin's lymphoma cell lines. (PubMed id 15812353)9 Yurchenko M.Y....Sidorenko S.P. (Exp. Oncol. 2005)
    999. Src kinase regulation by phosphorylation and dephosphorylation. (PubMed id 15845350)9 Roskoski R. (Biochem. Biophys. Res. Commun. 2005)
    1000. Prenatal DNA diagnosis of Noonan syndrome in a fetus with massive hygroma colli, pleural effusion and ascites. (PubMed id 16032767)9 SchlA1ter G....Pauer H.U. (Prenat. Diagn. 2005)
    1001. Differential sorting of tyrosine kinases and phosphotyrosine phosphatases acting on band 3 during vesiculation of human erythrocytes. (PubMed id 14527338)9 Minetti G....Balduini C. (Biochem. J. 2004)
    1002. Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells. (PubMed id 15272025)9 Hayashi K....Sobue K. (J. Biol. Chem. 2004)
    1003. [Expression of host genes in influenza virus infected cells]. (PubMed id 15745156)9 Shimizu K. and Kuroda K. (Uirusu 2004)
    1004. Adenosine acts through A2 receptors to inhibit IL-2-induced tyrosine phosphorylation of STAT5 in T lymphocytes: role of cyclic adenosine 3',5'-monophosphate and phosphatases. (PubMed id 15240680)9 Zhang H....Hoskin D.W. (J. Immunol. 2004)
    1005. The TEL/ARG leukemia oncogene promotes viability and hyperresponsiveness to hematopoietic growth factors. (PubMed id 15005341)9 Okuda K....Griffin J.D. (Int. J. Hematol. 2004)
    1006. Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein alpha1. (PubMed id 15349900)9 Yan H.X....Wu M.C. (Hepatology 2004)
    1007. Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases. (PubMed id 14762163)9 Persson C....Ostman A. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    1008. Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins. (PubMed id 15289498)9 Goel H.L....Languino L.R. (J. Cell Biol. 2004)
    1009. Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. (PubMed id 14699500)9 Judd L.M....Giraud A.S. (Gastroenterology 2004)
    1010. Mutations in PTPN11 are uncommon in adult myelodysplastic syndromes and acute myeloid leukaemia. (PubMed id 15009076)9 Johan M.F....Reilly J.T. (Br. J. Haematol. 2004)
    1011. The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo. (PubMed id 15501480)9 Campbell C.S....Carvalho C.R. (Life Sci. 2004)
    1012. Juvenile myelomonocytic leukemia. (PubMed id 15087069)9 Emanuel P.D. (Curr. Hematol. Rep. 2004)
    1013. A novel PTPN11 gene mutation bridges Noonan syndrome, multiple lentigines/LEOPARD syndrome and Noonan-like/multiple giant cell lesion syndrome. (PubMed id 15470362)9 Sarkozy A....Dallapiccola B. (Eur. J. Hum. Genet. 2004)
    1014. The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells. (PubMed id 15557178)9 Avril T....Crocker P.R. (J. Immunol. 2004)
    1015. Role of the Grb2-associated binder 1/SHP-2 interaction in cell growth and transformation. (PubMed id 15026337)9 Holgado-Madruga M. and Wong A.J. (Cancer Res. 2004)
    1016. PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. (PubMed id 15358536)9 Sheppard K.A....Chaudhary D. (FEBS Lett. 2004)
    1017. Childhood and adolescent lymphoid and myeloid leukemia. (PubMed id 15561680)9 Pui C.H....Niemeyer C.M. (Hematology Am Soc Hematol Educ Program 2004)
    1018. The molecular basis of leukemia. (PubMed id 15561678)9 Gilliland D.G....Felix C.A. (Hematology Am Soc Hematol Educ Program 2004)
    1019. Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture. (PubMed id 14732700)9 Toyama-Sorimachi N....Karasuyama H. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    1020. Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells. (PubMed id 15351743)9 Maeda K....Takahashi M. (Biochem. Biophys. Res. Commun. 2004)
    1021. The ability of protein tyrosine phosphatase SHP-1 to suppress NFkappaB can be inhibited by dominant negative mutant of SIRPalpha. (PubMed id 15068587)9 Neznanov N....Gudkov A.V. (DNA Cell Biol. 2004)
    1022. A 3-bp deletion mutation of PTPN11 in an infant with severe Noonan syndrome including hydrops fetalis and juvenile myelomonocytic leukemia. (PubMed id 15211660)9 Yoshida R....Ogata T. (Am. J. Med. Genet. A 2004)
    1023. IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes. (PubMed id 15184070)9 Sui L....Cao X. (Biochem. Biophys. Res. Commun. 2004)
    1024. SHP-2 and myeloid malignancies. (PubMed id 14676626)9 Tartaglia M....Loh M.L. (Curr. Opin. Hematol. 2004)
    1025. Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library. (PubMed id 14578355)9 WAolchli S....Hooft van Huijsduijnen R. (J. Biol. Chem. 2004)
    1026. Somatic PTPN11 mutation with a heterogeneous clonal origin in children with juvenile myelomonocytic leukemia. (PubMed id 15085150)9 Shimada H....Kosaki K. (Leukemia 2004)
    1027. Paternal germline origin and sex-ratio distortion in transmission of PTPN11 mutations in Noonan syndrome. (PubMed id 15248152)9 Tartaglia M....Gelb B.D. (Am. J. Hum. Genet. 2004)
    1028. KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity. (PubMed id 15238421)9 Han Y....Cao X. (Blood 2004)
    1029. NSAIDs activate PTEN and other phosphatases in human colon cancer cells: novel mechanism for chemopreventive action of NSAIDs. (PubMed id 15240129)9 Chu E.C....Tarnawski A.S. (Biochem. Biophys. Res. Commun. 2004)
    1030. Functional significance of Tie2 signaling in the adult vasculature. (PubMed id 14749497)9 Peters K.G....Sankar S. (Recent Prog. Horm. Res. 2004)
    1031. Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2. (PubMed id 15170389)9 Arnaud M....Bertoglio J. (Biochem. J. 2004)
    1032. The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses. (PubMed id 15163498)9 Seo S.H....Webster R.G. (Virus Res. 2004)
    1033. Role of immunoreceptor tyrosine-based inhibitory motifs of PECAM-1 in PECAM-1-dependent cell migration. (PubMed id 15201144)9 O'Brien C.D....DeLisser H.M. (Am. J. Physiol., Cell Physiol. 2004)
    1034. Human parvovirus B19 transgenic mice become susceptible to polyarthritis. (PubMed id 15383603)9 Takasawa N....Sasaki T. (J. Immunol. 2004)
    1035. [Crucial roles of PECAM-1 in shear stress sensing of vascular endothelial cells]. (PubMed id 15502396)9 Masuda M....Mochizuki N. (Nippon Yakurigaku Zasshi 2004)
    1036. Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells. (PubMed id 14712221)9 Fernandis A.Z....Ganju R.K. (Oncogene 2004)
    1037. Phosphotyrosine phosphatases acting on band 3 in human erythrocytes of different age: PTP1B processing during cell ageing. (PubMed id 15039022)9 Ciana A....Balduini C. (Bioelectrochemistry 2004)
    1038. Different mutations in the NF1 gene are associated with neurofibromatosis-Noonan syndrome (NFNS). (PubMed id 12707950)9 Baralle D.... ffrench-Constant C. (Am. J. Med. Genet. A 2003)
    1039. The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts. (PubMed id 12721296)9 MacGillivray M....Downey G.P. (J. Biol. Chem. 2003)
    1040. Reactive oxygen species induce reversible PECAM-1 tyrosine phosphorylation and SHP-2 binding. (PubMed id 12893640)9 Maas M....Newman D.K. (Am. J. Physiol. Heart Circ. Physiol. 2003)
    1041. Identification of protein tyrosine phosphatases associating with the PDGF receptor. (PubMed id 12614164)9 Markova B....BAPhmer F.D. (Biochemistry 2003)
    1042. Antiphospholipid antibodies in pediatric and adult patients with rheumatic disease are associated with parvovirus B19 infection. (PubMed id 12847688)9 Von Landenberg P....Modrow S. (Arthritis Rheum. 2003)
    1043. PTPN11 mutation in a young man with Noonan syndrome and retinitis pigmentosa. (PubMed id 12872825)9 Schollen E....Fryns J.F. (Genet. Couns. 2003)
    1044. Nonsyndromic pulmonary valve stenosis and the PTPN11 gene. (PubMed id 12522798)9 Sarkozy A....Paoletti V. (Am. J. Med. Genet. A 2003)
    1045. Calcium channel upregulation in response to activation of neurotrophin and surrogate neurotrophin receptor tyrosine kinases. (PubMed id 13130503)9 Black M.J....Rane S.G. (J. Neurosci. Res. 2003)
    1046. Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors. (PubMed id 12458214)9 Li C....Li S.S. (J. Biol. Chem. 2003)
    1047. The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. (PubMed id 12826400)9 Neel B.G....Pao L. (Trends Biochem. Sci. 2003)
    1048. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. (PubMed id 12730241)9 Cai D.... Shoelson S.E. (J. Biol. Chem. 2003)
    1049. Gab1, SHP-2 and other novel regulators of Ras: targets for anticancer drug discovery? (PubMed id 12769687)9 Yart A....Raynal P. (Curr Cancer Drug Targets 2003)
    1050. Initiation and maintenance of CNTF-Jak/STAT signaling in neurons is blocked by protein tyrosine phosphatase inhibitors. (PubMed id 12941469)9 Jiao J....Halvorsen S.W. (Brain Res. Mol. Brain Res. 2003)
    1051. Frequent infection with a viral pathogen, parvovirus B19, in rheumatic diseases of childhood. (PubMed id 12794831)9 Lehmann H.W....Modrow S. (Arthritis Rheum. 2003)
    1052. Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines. (PubMed id 14511121)9 Kaur N....Halvorsen S.W. (J. Neurochem. 2003)
    1053. Tyr-c[D-Orn-Tyr(Bzl)-Pro-Gly]: a novel antiproliferative acting somatostatin receptor agonist with mu-opioid receptor-sensitizing properties. (PubMed id 12967930)9 Stirnweiss J....Liebmann C. (Br. J. Pharmacol. 2003)
    1054. No mutation in the gene for Noonan syndrome, PTPN11, in 18 patients with Costello syndrome. (PubMed id 12900909)9 TrAPger B....Meinecke P. (Am. J. Med. Genet. A 2003)
    1055. Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response. (PubMed id 12594211)9 Yuan L....Qu C.K. (J. Biol. Chem. 2003)
    1056. Assessing the redundancy of MADS-box genes during carpel and ovule development. (PubMed id 12840762)9 Pinyopich A....Yanofsky M.F. (Nature 2003)
    1057. SAP couples Fyn to SLAM immune receptors. (PubMed id 12545174)9 Chan B.... Eck M.J. (Nat. Cell Biol. 2003)
    1058. Antibodies from dengue patient sera cross-react with endothelial cells and induce damage. (PubMed id 12436482)9 Lin C.F....Lin Y.S. (J. Med. Virol. 2003)
    1059. The role of somatropin therapy in children with Noonan syndrome. (PubMed id 15966565)9 Kelnar C.J. (Treat Endocrinol 2003)
    1060. Desensitization of signaling by oncostatin M in human vascular cells involves cytoplasmic Tyr residue 759 in gp130 but is not mediated by either Src homology 2 domain-containing tyrosine phosphatase 2 or suppressor of cytokine signaling 3. (PubMed id 12724316)9 Mahboubi K....Pober J.S. (J. Biol. Chem. 2003)
    1061. Protein phosphatase-2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants. (PubMed id 12856723)9 Jackson J.L. and Young M.R. (amp 2003)
    1062. Reactive oxygen species as mediators of cell adhesion. (PubMed id 12833635)9 Chiarugi P. (Ital. J. Biochem. 2003)
    1063. Scaffolding protein Gab2 mediates fibroblast transformation by the SEA tyrosine kinase. (PubMed id 14508511)9 Ischenko I....Hayman M.J. (Oncogene 2003)
    1064. Activation of SRC tyrosine kinases in response to ICAM-1 ligation in pulmonary microvascular endothelial cells. (PubMed id 14504278)9 Wang Q....Gaarde W.A. (J. Biol. Chem. 2003)
    1065. Crystal structure of human protein-tyrosine phosphatase SHP-1. (PubMed id 12482860)9 Yang J.... Zhou G.W. (J. Biol. Chem. 2003)
    1066. Production of growth related oncogene protein-alpha in human umbilical vein endothelial cells stimulated with soluble interleukin-6 receptor-alpha: role of signal transducers, janus kinase 2 and mitogen-activated kinase kinase. (PubMed id 12008100)9 Matsumiya T....Satoh K. (Life Sci. 2002)
    1067. Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor. (PubMed id 12357354)9 Tse K.F....Small D. (Leukemia 2002)
    1068. Anticancer activity of sodium stibogluconate in synergy with IFNs. (PubMed id 12421984)9 Yi T....Borden E.C. (J. Immunol. 2002)
    1069. Specificity of interleukin-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway. (PubMed id 11788580)9 Xiao H....Yang Y.C. (J. Biol. Chem. 2002)
    1070. Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B. (PubMed id 11806712)9 Larsen S.D....Bleasdale J.E. (J. Med. Chem. 2002)
    1071. Expression of interferon alfa signaling components in human alcoholic liver disease. (PubMed id 11826419)9 Nguyen V.A. and Gao B. (Hepatology 2002)
    1072. Inhibition of the PDGF receptor by red wine flavonoids provides a molecular explanation for the &quot;French paradox&quot;. (PubMed id 12397093)9 Rosenkranz S....BAPhm M. (FASEB J. 2002)
    1073. Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response. (PubMed id 12421673)9 Qu C.K. (Biochim. Biophys. Acta 2002)
    1074. Parvovirus B19 nonstructural (NS1) protein as a transactivator of interleukin-6 synthesis: common pathway in inflammatory sequelae of human parvovirus infections? (PubMed id 11992589)9 Mitchell L.A. (J. Med. Virol. 2002)
    1075. Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding. (PubMed id 12207897)9 Newman D.K....Newman P.J. (Biochem. Biophys. Res. Commun. 2002)
    1076. The first Noonan syndrome gene: PTPN11, which encodes the protein tyrosine phosphatase SHP-2. (PubMed id 12357036)9 Allanson J. (Pediatr. Res. 2002)
    1077. Nonreceptor protein tyrosine and lipid phosphatases in type I fc(epsilon) receptor-mediated activation of mast cells and basophils. (PubMed id 12218363)9 Heneberg P. and DrA!ber P. (Int. Arch. Allergy Immunol. 2002)
    1078. Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule? (PubMed id 12177047)9 Osawa M....Fujiwara K. (J. Cell Biol. 2002)
    1079. Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets. (PubMed id 11756163)9 Cicmil M....Gibbins J.M. (Blood 2002)
    1080. Molecular events associated with CD4-mediated Down-regulation of LFA-1-dependent adhesion. (PubMed id 11694542)9 Mazerolles F....Fischer A. (J. Biol. Chem. 2002)
    1081. Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes. (PubMed id 12220227)9 Hers I....TavarAc J.M. (Biochem. J. 2002)
    1082. High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. (PubMed id 12355369)9 Libraty D.H....Rothman A.L. (J. Infect. Dis. 2002)
    1083. RAFTK/Pyk2 involvement in platelet activation is mediated by phosphoinositide 3-kinase. (PubMed id 11472358)9 Koziak K....Avraham H. (Br. J. Haematol. 2001)
    1084. Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation. (PubMed id 11516103)9 Bruecher-Encke B....Lorenz U. (Leukemia 2001)
    1085. Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. (PubMed id 11294897)9 Hart K.C.... Donoghue D.J. (Mol. Biol. Cell 2001)
    1086. FcgammaRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization. (PubMed id 11709085)9 Jensen W.A....Cambier J.C. (Biochem. Soc. Trans. 2001)
    1087. Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor. (PubMed id 11695994)9 Bisotto S. and Fixman E.D. (Biochem. J. 2001)
    1088. Hyperattenuated recombinant influenza A virus nonstructural-protein-encoding vectors induce human immunodeficiency virus type 1 Nef-specific systemic and mucosal immune responses in mice. (PubMed id 11533153)9 Ferko B....Egorov A. (J. Virol. 2001)
    1089. Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. (PubMed id 11572860)9 Yamasaki S....Saito T. (J. Biol. Chem. 2001)
    1090. Targeting Src homology 2 domain-containing tyrosine phosphatase (SHP-1) into lipid rafts inhibits CD3-induced T cell activation. (PubMed id 11238643)9 Su M.W....Jin Y.J. (J. Immunol. 2001)
    1091. Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of Lyn. (PubMed id 11289114)9 Tilbrook P.A....Klinken S.P. (Cancer Res. 2001)
    1092. Multiple effector domains within SNT1 coordinate ERK activation and neuronal differentiation of PC12 cells. (PubMed id 11278583)9 Xu H. and Goldfarb M. (J. Biol. Chem. 2001)
    1093. PECAM-1 shedding during apoptosis generates a membrane-anchored truncated molecule with unique signaling characteristics. (PubMed id 11156952)9 Ilan N....Madri J.A. (FASEB J. 2001)
    1094. CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. (PubMed id 11443118)9 Arai A.... Miura O. (J. Biol. Chem. 2001)
    1095. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. (PubMed id 11294841)9 LeliA"vre E....Gascan H. (J. Biol. Chem. 2001)
    1096. Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure. (PubMed id 11584002)9 Shen K....Zhang Z.Y. (J. Biol. Chem. 2001)
    1097. Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics. (PubMed id 11741477)9 Jia Z....Taylor S.D. (J. Med. Chem. 2001)
    1098. Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo). (PubMed id 11402314)9 Bouscary D....Lacombe C. (Oncogene 2001)
    1099. Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells. (PubMed id 11196191)9 Badache A. and Hynes N.E. (Cancer Res. 2001)
    1100. Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2. (PubMed id 11335710)9 Craddock B.L....Welham M.J. (J. Biol. Chem. 2001)
    1101. SHP-2 complex formation with the SHP-2 substrate-1 during C2C12 myogenesis. (PubMed id 11493654)9 Kontaridis M.I....Bennett A.M. (J. Cell. Sci. 2001)
    1102. Insufficient phosphorylation prevents fc gamma RIIB from recruiting the SH2 domain-containing protein-tyrosine phosphatase SHP-1. (PubMed id 11099496)9 Lesourne R....DaAron M. (J. Biol. Chem. 2001)
    1103. A regulatory role for cytoplasmic YVKM motif in CTLA-4 inhibition of TCR signaling. (PubMed id 11449357)9 Schneider H....Rudd C.E. (Eur. J. Immunol. 2001)
    1104. Tumor necrosis factor alpha attenuates interferon alpha signaling in the liver: involvement of SOCS3 and SHP2 and implication in resistance to interferon therapy. (PubMed id 11427497)9 Hong F....Gao B. (FASEB J. 2001)
    1105. The requirement of tyrosines 579 and 581 for maximal ligand-dependent activation of the betaPDGFR is influenced by noncytoplasmic regions of the receptor. (PubMed id 11281646)9 Nickas M.E....Kazlauskas A. (Exp. Cell Res. 2001)
    1106. Regulation of Ras and Rho small G proteins by SHP-2. (PubMed id 11683915)9 Kodama A....Takai Y. (amp 2001)
    1107. A model of activation of the protein tyrosine phosphatase SHP-2 by the human leptin receptor. (PubMed id 11342028)9 LAPthgren A....James S.R. (Biochim. Biophys. Acta 2001)
    1108. Production and characterization of a Tie2 agonist monoclonal antibody. (PubMed id 11824375)9 Hansbury M.J....Winkler J.D. (Angiogenesis 2001)
    1109. [Role of leptin and its receptor in the regulation of appetite and body fat]. (PubMed id 11268587)9 Shimizu H. and Mori M. (Nippon Rinsho 2001)
    1110. Low M(r) protein tyrosine phosphatase inhibits growth and migration of vascular smooth muscle cells induced by platelet-derived growth factor. (PubMed id 11716518)9 Shimizu H....Miyazaki H. (Biochem. Biophys. Res. Commun. 2001)
    1111. Co-clustering of Fcgamma and B cell receptors induces dephosphorylation of the Grb2-associated binder 1 docking protein. (PubMed id 11453982)9 Koncz G....SA!rmay G. (Eur. J. Biochem. 2001)
    1112. The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase. (PubMed id 11278704)9 Ingham R.J....Gold M.R. (J. Biol. Chem. 2001)
    1113. Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action. (PubMed id 11341829)9 Bleasdale J.E....Larsen S.D. (Biochemistry 2001)
    1114. IL-4/IL-13 signaling beyond JAK/STAT. (PubMed id 10856136)9 Jiang H....Rothman P. (J. Allergy Clin. Immunol. 2000)
    1115. The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines. (PubMed id 10849428)9 Gadina M....O'Shea J.J. (J. Biol. Chem. 2000)
    1116. Negative regulation of FcepsilonRI signaling by FcgammaRII costimulation in human blood basophils. (PubMed id 10932079)9 Kepley C.L....Oliver J.M. (J. Allergy Clin. Immunol. 2000)
    1117. Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA. (PubMed id 10922477)9 Terstegen L....Gatsios P. (FEBS Lett. 2000)
    1118. Inactivation of wild-type BCR/ABL tyrosine kinase in hematopoietic cells by mild hyperthermia. (PubMed id 10803516)9 Jain S.K....Varticovski L. (Leukemia 2000)
    1119. Effects of Src homology domain 2 (SH2)-containing inositol phosphatase (SHIP), SH2-containing phosphotyrosine phosphatase (SHP)-1, and SHP-2 SH2 decoy proteins on Fc gamma RIIB1-effector interactions and inhibitory functions. (PubMed id 10623804)9 Nakamura K....Cambier J.C. (J. Immunol. 2000)
    1120. Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. (PubMed id 10764762)9 Xu M.-J.... Zhao Z.J. (J. Biol. Chem. 2000)
    1121. The protein tyrosine phosphatase Shp-2 regulates RhoA activity. (PubMed id 11114521)9 Schoenwaelder S.M....Burridge K. (Curr. Biol. 2000)
    1122. An immunoreceptor tyrosine-based inhibitory motif, with serine at site Y-2, binds SH2-domain-containing phosphatases. (PubMed id 10651806)9 Philosof-Oppenheimer R....Pecht I. (Eur. J. Biochem. 2000)
    1123. Dengue virus nonstructural protein 1 is expressed in a glycosyl-phosphatidylinositol-linked form that is capable of signal transduction. (PubMed id 10928995)9 Jacobs M.G....Young P.R. (FASEB J. 2000)
    1124. Mutational analysis reveals multiple distinct sites within Fc gamma receptor IIB that function in inhibitory signaling. (PubMed id 11035084)9 Fong D.C....Cambier J.C. (J. Immunol. 2000)
    1125. CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1. (PubMed id 10940903)9 Vernon-Wilson E.F....Brown M.H. (Eur. J. Immunol. 2000)
    1126. Protein tyrosine phosphatase activity is required for IL-4 induction of IL-4 receptor alpha-chain. (PubMed id 10640732)9 Huang H. and Paul W.E. (J. Immunol. 2000)
    1127. Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor. (PubMed id 10788507)9 Cunnick J.M....Wu J. (J. Biol. Chem. 2000)
    1128. Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin II in endothelial cells. Roles of Yes tyrosine kinase and tyrosine phosphatase SHP-2. (PubMed id 10722671)9 Tang H....Inagami T. (J. Biol. Chem. 2000)
    1129. Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4. (PubMed id 10842319)9 Chikuma S.... Uede T. (J. Cell. Biochem. 2000)
    1130. Characterization of Drosophila insulin receptor substrate. (PubMed id 10801879)9 Poltilove R.M....Taylor S.I. (J. Biol. Chem. 2000)
    1131. The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. (PubMed id 10833515)9 Sattler M....Griffin J.D. (J. Biol. Chem. 2000)
    1132. Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase. (PubMed id 10995764)9 Besset V....IbA!A+ez C.F. (J. Biol. Chem. 2000)
    1133. Identification of natural ligands for SH2 domains from a phage display cDNA library. (PubMed id 10704309)9 Cochrane D....McCafferty J. (J. Mol. Biol. 2000)
    1134. Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap1 GTPase. (PubMed id 11043767)9 Gold M.R....Matsuuchi L. (Immunol. Rev. 2000)
    1135. The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functions. (PubMed id 11191350)9 Qu C.K. (Cell Res. 2000)
    1136. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. (PubMed id 10660596)9 Goldstein B.J....Harbeck M. (J. Biol. Chem. 2000)
    1137. Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2. (PubMed id 11088001)9 Florio T....Stork P.J. (J. Physiol. Paris 2000)
    1138. Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors. (PubMed id 10752981)9 Hibi M. and Hirano T. (amp 2000)
    1139. v-Src suppresses SHPS-1 expression via the Ras-MAP kinase pathway to promote the oncogenic growth of cells. (PubMed id 10763828)9 Machida K....Hamaguchi M. (Oncogene 2000)
    1140. An SPR-based screening method for agonist selectivity for insulin signaling pathways based on the binding of phosphotyrosine to its specific binding protein. (PubMed id 10655627)9 Yoshida T....Umezawa Y. (Anal. Chem. 2000)
    1141. Cysteine 981 of the human insulin receptor is required for covalent cross-linking between beta-subunit and a thiol-reactive membrane-associated protein. (PubMed id 10852716)9 Garant M.J....Bernier M. (Biochemistry 2000)
    1142. Thrombin-induced association of SHP-2 with multiple tyrosine-phosphorylated proteins in human platelets. (PubMed id 10508911)9 Edmead C.E....Poole A.W. (FEBS Lett. 1999)
    1143. Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells. (PubMed id 10329697)9 Ward A.C....Touw I.P. (J. Biol. Chem. 1999)
    1144. Distinct actions of interleukin-9 and interleukin-4 on a hematopoietic stem cell line, EMLC1. (PubMed id 9923452)9 Wang X.Y....Yang Y.C. (Exp. Hematol. 1999)
    1145. Constitutive activation of JAK2 confers murine interleukin-3-independent survival and proliferation of BA/F3 cells. (PubMed id 10037724)9 Liu C.B....Watanabe S. (J. Biol. Chem. 1999)
    1146. Differential influence of tyrosine residues of the common receptor beta subunit on multiple signals induced by human GM-CSF. (PubMed id 10329850)9 Itoh T....Watanabe S. (J. Allergy Clin. Immunol. 1999)
    1147. Alpha-galactosyl-mediated activation of porcine endothelial cells: studies on CD31 and VE-cadherin in adhesion and signaling. (PubMed id 10515388)9 Nasu K....Kilshaw P.J. (Transplantation 1999)
    1148. IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, phosphatidylinositol 3'-kinase, and Grb2. (PubMed id 9973481)9 Gadina M....O'Shea J.J. (J. Immunol. 1999)
    1149. Different protein turnover of interleukin-6-type cytokine signalling components. (PubMed id 10491180)9 Siewert E....Schaper F. (Eur. J. Biochem. 1999)
    1150. Prevalence of antibodies to human parvovirus B19 nonstructural protein in persons with various clinical outcomes following B19 infection. (PubMed id 10395869)9 Jones L.P....Anderson L.J. (J. Infect. Dis. 1999)
    1151. Engagement of Gab1 and Gab2 in erythropoietin signaling. (PubMed id 10455108)9 Wickrema A....Platanias L.C. (J. Biol. Chem. 1999)
    1152. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. (PubMed id 10380925)9 Fambrough D....Lander E.S. (Cell 1999)
    1153. Regulation of megakaryocytopoiesis and platelet production by tyrosine kinases and tyrosine phosphatases. (PubMed id 10080910)9 Avraham H. and Price D.J. (Methods 1999)
    1154. Tyrosine phosphatase SHP-2 is involved in regulation of platelet-derived growth factor-induced migration. (PubMed id 10318871)9 Qi J.H....Claesson-Welsh L. (J. Biol. Chem. 1999)
    1155. A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum. (PubMed id 10022908)9 MariA^n R.M....OrtA-n J. (Mol. Cell. Biol. 1999)
    1156. Kinetic comparison of the catalytic domains of SHP-1 and SHP-2. (PubMed id 10025675)9 Niu T....Zhou G.W. (J. Cell. Biochem. 1999)
    1157. [T cell receptor and its related molecules in signal transduction]. (PubMed id 10077990)9 Kobata T. and Morimoto C. (Nippon Rinsho 1999)
    1158. Cas mediates transcriptional activation of the serum response element by Src. (PubMed id 10490632)9 Hakak Y. and Martin G.S. (Mol. Cell. Biol. 1999)
    1159. Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor. (PubMed id 10391888)9 DeMali K.A....Kazlauskas A. (J. Biol. Chem. 1999)
    1160. Control of parvovirus DNA replication by a tetracycline-regulated repressor. (PubMed id 10435080)9 Maxwell I.H. and Maxwell F. (Gene Ther. 1999)
    1161. Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor. (PubMed id 10372132)9 Okuda K....Griffin J.D. (Ann. N. Y. Acad. Sci. 1999)
    1162. Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and phosphatidylinositol 3-kinase. (PubMed id 10194437)9 Lecoq-Lafon C....Mayeux P. (Blood 1999)
    1163. Signal regulatory proteins negatively regulate immunoreceptor-dependent cell activation. (PubMed id 10542295)9 LiAcnard H....DaAron M. (J. Biol. Chem. 1999)
    1164. Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. (PubMed id 9973379)9 Chuang E....Thompson C.B. (J. Immunol. 1999)
    1165. The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes. (PubMed id 10359809)9 Li H.L....PurAc E. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    1166. Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration. (PubMed id 10343075)9 Bird I.N....Buckley C.D. (J. Cell. Sci. 1999)
    1167. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. (PubMed id 10540326)9 Cantoni C.... Moretta A. (Eur. J. Immunol. 1999)
    1168. Activation of epithelial growth factor receptor pathway by unsaturated fatty acids. (PubMed id 10559135)9 Vacaresse N....NA"gre-Salvayre A. (Circ. Res. 1999)
    1169. Regulation of tyrosine phosphorylation in isolated T cell membrane by inhibition of protein tyrosine phosphatases. (PubMed id 9712039)9 Jin Y.J....Burakoff S.J. (J. Immunol. 1998)
    1170. [The signal transduction of receptor tyrosine kinase]. (PubMed id 9702050)9 Takada T....Kasuga M. (Nippon Rinsho 1998)
    1171. NK cell receptors. (PubMed id 9597134)9 Lanier L.L. (Annu. Rev. Immunol. 1998)
    1172. Development of antibodies to the nonstructural protein NS1 of parvovirus B19 during acute symptomatic and subclinical infection in pregnancy: implications for pathogenesis doubtful. (PubMed id 9783684)9 Searle K....Enders G. (J. Med. Virol. 1998)
    1173. Molecular basis of T cell inactivation by CTLA-4. (PubMed id 9856951)9 Lee K.M....Bluestone J.A. (Science 1998)
    1174. Platelet-derived growth factor stimulates protein kinase D through the activation of phospholipase Cgamma and protein kinase C. (PubMed id 9507012)9 Van Lint J....Vandenheede J.R. (J. Biol. Chem. 1998)
    1175. Cytoplasmic domains of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor beta chain (hbetac) responsible for human GM-CSF-induced myeloid cell differentiation. (PubMed id 9677359)9 Matsuguchi T....Kraft A.S. (J. Biol. Chem. 1998)
    1176. Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor. (PubMed id 9447970)9 Itoh T....Watanabe S. (Mol. Cell. Biol. 1998)
    1177. Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role. (PubMed id 9590209)9 Gadina M....O'Shea J.J. (J. Immunol. 1998)
    1178. The specificity of the N-terminal SH2 domain of SHP-2 is modified by a single point mutation. (PubMed id 9485424)9 Huyer G. and Ramachandran C. (Biochemistry 1998)
    1179. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. (PubMed id 9885561)9 Gu H....Neel B.G. (Mol. Cell 1998)
    1180. Phosphatidylinositol 3'-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase. (PubMed id 9761740)9 Cengel K.A....Freund G.G. (Biochem. J. 1998)

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    Entrez Gene: 5781 HGNC: 9644 AceView: RPL6 Ensembl:ENSG00000179295 euGenes: HUgn5781
    ECgene: PTPN11 Kegg: 5781 H-InvDB: PTPN11

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